Patents Assigned to SANDOZ
  • Boric acid esters
    Patent number: 4021464
    Abstract: The invention provides novel boric acid esters, useful as flame retardants.
    Type: Grant
    Filed: March 7, 1975
    Date of Patent: May 3, 1977
    Assignee: Sandoz Ltd.
    Inventors: Horst Mayerhoefer, Wolfgang Mueller, Urs Sollberger
  • Dibromination process
    Patent number: 4021492
    Abstract: The .alpha.,.alpha.-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.,.alpha.-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125.degree. C.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: May 3, 1977
    Assignee: Sandoz, Inc.
    Inventors: Jerome Linder, William J. Houlihan
  • 5-(2-Aminophenyl)-s-triazoles
    Patent number: 4020083
    Abstract: Anti-inflammatory agents of the formula: ##STR1## wherein R.degree. is hydrogen, halo, alkoxy, alkyl, or CF.sub.3 or two adjacent R.degree. together may also form methylenedioxy,R is hydrogen or lower alkyl, andn is 1 or 2.
    Type: Grant
    Filed: July 8, 1975
    Date of Patent: April 26, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • N-(Substituted carbonylmethyl) isatoic anhydrides
    Patent number: 4020062
    Abstract: Isatoic anhydrides of the formula: ##STR1## wherein R is alkyl, phenyl or phenalkyl and R.sub.1 and R.sub.2 are hydrogen, halo, alkyl, alkoxy or together methylenedioxy are intermediates reactable with an acyclic 5-methyl-thiopseudourea and acetonitrile to pharmaceutical agents, for example, analgetic and hypotensive agents, of the formula: ##STR2## wherein R, R.sub.1 and R.sub.2 are as defined and R.sup.o is hydrogen, alkyl, .omega.-alkenyl or phenyl.
    Type: Grant
    Filed: January 3, 1975
    Date of Patent: April 26, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Haloalkyl esters of 5-nitroimidazole-1-carboxylic acid derivatives
    Patent number: 4020166
    Abstract: This invention provides compounds of the formula, ##STR1## in which R.sub.1 signifies straight or branched chain alkyl in which a single methyl group is replaced by a mono-, di- or tri-halomethyl group; R.sub.2 signifies hydrogen or straight or branched chain lower alkyl and X and Z each independently signifies oxygen or sulphur, which are useful as animal feed additives and amoebicidal agents.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: April 26, 1977
    Assignee: Sandoz, Ltd.
    Inventors: Hans Nesvadba, Hellmuth Reinshagen
  • 5-Substituted-2-(2')-benzimidazoyl-furans
    Patent number: 4018789
    Abstract: Disclosed are optical brightening agents, such agents being 2-(2')-benzimidazoyl-furans substituted in the 5-position of the furan ring by a 1-aryl-pyrazolyl-3, -4 or -5 radical, by a pyrazolyl-1 radical or by a 2-aryl-v-triazolyl-4 radical, such compounds being in free base, acid addition or quaternary ammonium salt form.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: April 19, 1977
    Assignee: Sandoz Ltd.
    Inventors: Peter Stuart Littlewood, Alec Victor Mercer
  • Pressure indicators for inflatable cuff-type catheters
    Patent number: 4016885
    Abstract: Inflatable cuff-type catheters, e.g., endotracheal and tracheotomy tubes, with cuff pressure indicators are provided. One indicator means comprises an expandable chamber with an open-ended spring about the mid-section of the chamber. As the chamber expands, the spring also expands to indicate the gas pressure in the cuff.
    Type: Grant
    Filed: June 30, 1975
    Date of Patent: April 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: James D. Bruner
  • Water-soluble azo dyes having a 2-acetoacetamidofluorenyl coupling component radical
    Patent number: 4017478
    Abstract: Dyes of the formula ##STR1## wherein D is a carbocyclic aryl or heterocyclic aryl diazo component radical,q is 0 to 3, andt is 0, 1 or 2,With the proviso that q + t is 1 to 5, are highlyThe dyeing, padding and printing of textile fibers and textiles of natural or regenerated cellulose and paper. The dyes build-up well, exhibit good fastness to wet treatments, alcohol, light, rubbing and dry cleaning and are resistant to acids and alkalis.
    Type: Grant
    Filed: September 6, 1974
    Date of Patent: April 12, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • 6H(1)-Benzopyrano(3,2-c)quinolines
    Patent number: 4017499
    Abstract: Anti-inflammatory agents of the formula: ##STR1## wherein R is lower alkyl, lower alkenyl, lower alkynyl, benzyl, alkyl or halo-substituted benzyl or cycloalkylalkyl, X is CH or N, R' is hydrogen, halo, lower alkyl or lower alkoxy when X is CH and hydrogen and alkyl when X is N, and R" is hydrogen or lower alkyl.
    Type: Grant
    Filed: April 5, 1976
    Date of Patent: April 12, 1977
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Oxadiazolyl benzamides
    Patent number: 4016170
    Abstract: Substituted or unsubstituted oxadiazolyl benzamides, e.g., o-(3-phenyl-1,2,4-oxadiazol-5-yl)-N-methyl-benzamide, are prepared by reacting a corresponding substituted or unsubstituted oxadiazoyl benzoic acid alkyl ester with an amine and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: April 5, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Process for the production of aminoanthraquinone compounds
    Patent number: 4016182
    Abstract: The present invention concerns a novel process for the reduction of a nitro-anthraquinone compound of formula I: ##STR1## wherein M IS AN INTEGER 1, 2 OR 3, ANDn is an integer 1, 2 or 3,The sum of m + n being 3, 4 or 5, and the rings A and B are either further substituted or unsubstituted,To the corresponding amino-anthraquinone compound which comprises reacting the compound of formula I with hydrazine in aqueous medium. The resulting amino-anthraquinone compounds are in general known and are useful intermediates in the production of anthraquinone dyestuffs.
    Type: Grant
    Filed: May 22, 1974
    Date of Patent: April 5, 1977
    Assignee: Sandoz Ltd.
    Inventor: Paul Buecheler
  • Synergistic insecticidal compositions containing .beta.-exotoxin
    Patent number: 4016265
    Abstract: A synergistic insecticidal composition comprises as a first ingredient the .beta.-exotoxin of Bacillus thuringiensis or a metal salt thereof and has a second ingredient of one or more of the following chemical insecticides:O,o-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate,O,o-dimethyl, .alpha.,.alpha.,.alpha.-trichloro-1-hydroxyethyl phosphonate,.alpha.-methoxy-4H-1,3,2-benzodioxaphosphorin-2-thione,O,o,-dimethyl S-(.alpha.-(ethoxycarbonyl)benzyl) phosphorodithioate,O,o-dimethyl S-(4-chlorophenyl) phosphorothioateThe first and second ingredients are used generally in a ratio of about 0.5:1 to 2.0:1 and may be dispersed in a major portion of an agronomically acceptable carrier.
    Type: Grant
    Filed: November 8, 1971
    Date of Patent: April 5, 1977
    Assignee: Sandoz, Inc.
    Inventors: Tadahiko Inoue, Gosaburo Dowke, Hideo Itoh
  • Alkanoyl substituted benzoic acids and esters
    Patent number: 4015010
    Abstract: Alkanoyl substituted benzoic acids and esters, e.g., p-pivaloyl ethyl benzoate, are prepared by oxidizing alkanoyl substituted toluene and reacting with lower alkanols and are useful as hypolipidemic, anti-obesity, and anti-diabetic agents.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: March 29, 1977
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones
    Patent number: 4015005
    Abstract: The invention discloses 1,2,5,6-tetrahydro-4H-pyrrolo-(3,2,1-ij)quinolin-2-ones having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by treating a haloacetyl derivative of 1,2,3,4-tetrahydroquinoline with a Friedel-Crafts catalyst. The haloacetyl derivative of 1,2,3,4-tetrahydroquinoline may be prepared by reacting 1,2,3,4-tetrahydroquinoline with a haloacetyl halide at a mole ratio of 2:1 in the presence of an inert, organic solvent.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: March 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Organic compounds
    Patent number: 4013690
    Abstract: This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or phenyl, andR.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,Useful as anti-phlogistics, anti-pyretics, analagesics and inhibitors of blood platelet aggregation.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: March 22, 1977
    Assignee: Sandoz Ltd.
    Inventors: Annemarie Closse, Walter Haefliger, Daniel Hauser
  • 3-Pyridyl and pyridyl-N-oxide-furo[3,4-e]-as-triazines
    Patent number: 4013767
    Abstract: Substituted or unsubstituted-3-pyridyl and pyridyl-N-oxide-furo[3,4-e]-as-triazines, e.g., 5,7-dihydro-3-(2-pyridyl)-5,5,7,7-tetramethyl-furo[3,4-e] -as-triazine are prepared by reacting 2,2,5,5-tetramethyl-3,4(2H,5H)furandiones with substituted or unsubstituted pyridylcarboxamidic acid hydrazides and are useful as sleep inducers and minor tranquilizers.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: March 22, 1977
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • N ,N-diethyl-4-(2,4-dinitro-6-alkylsulfonylphenylazo)-2-alkoxy-5-alkyl-carb onylaminoanilines
    Patent number: 4013636
    Abstract: Monoazo compounds of the formula ##STR1## in which each of R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, signifies a methyl or ethyl radical, which are useful as disperse dyes for substrates comprising or consisting of synthetic or semi-synthetic hydrophobic high molecular weight polymers, e.g., linear aromatic polyesters, cellulose acetates and synthetic polyamides. The dyeings exhibit notable fastness to light, heat treatments, wet treatments, perspiration, solvents, lubricants, rubbing, cross-dyeing, ozone, flue gas and chlorine and resistance to permanent pressing, soil release finishes and reduction.
    Type: Grant
    Filed: December 17, 1974
    Date of Patent: March 22, 1977
    Assignee: Sandoz Ltd.
    Inventor: Ruedi Altermatt
  • 1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES
    Patent number: 4013646
    Abstract: CNS depressants of the formulae IA and IB: ##STR1## in which n and p are each 0 or 1, Z.sup.- is an anion and R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are optional substituents. Compounds IB may be prepared by reducing compounds IA which may be made by reacting a N-(.omega.-haloalkyl) isatoic anhydride with a cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole. Compounds IB may be also prepared by cyclizing a 1-(.omega.-haloalkyl)-2,3-dihydro-imidazo[2,1-b]quinazolin-1H-5-one. The compounds are anti-inflammatory, analgesic and immunosuppressant agents.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: March 22, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Sustained release tablet formulations
    Patent number: 4012498
    Abstract: This invention provides controlled, e.g., sustained release of drugs from medicament formulations containing a plurality of medicaments, wherein a desirable release pattern is maintained for both low concentration and high concentration drugs of the formulation.
    Type: Grant
    Filed: February 19, 1976
    Date of Patent: March 15, 1977
    Assignee: Sandoz, Inc.
    Inventors: Saul S. Kornblum, Samuel B. Stoopak
  • Purification of 1-nitroanthraquinone
    Patent number: 4012426
    Abstract: This invention provides a purification process for crude 1-nitroanthraquinone which comprises treating the crude 1-nitroanthraquinone with a base or a basic hydrolyzable salt, in the presence of a solvent and at an elevated temperature, and isolating the purified 1-nitroanthraquinone. The process particularly removes substantial proportions of dinitroanthraquinones and oxidation products.
    Type: Grant
    Filed: January 29, 1973
    Date of Patent: March 15, 1977
    Assignee: Sandoz Ltd.
    Inventor: Istvan Toth