Patents Assigned to SANDOZ
  • Patent number: 4011344
    Abstract: Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4", 4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenylcarbinols are prepared from the corresponding phenones and both the phenones and the phenylcarbinols are useful as hypolipidemic agents.
    Type: Grant
    Filed: June 20, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4011323
    Abstract: Disclosed are bi-4-[1-(quinazolinyl-4)piperidyls] and bis{4-[1-(quinazolinyl-4)piperidyl]alkanes}, e.g. 1,3-bis{4-[1-(6,7-dimethylquinazolinyl-4)piperidyl]propane}, having pharmacological activity in animals and useful for example, as anti-obesity and anti-diabetic agents. Said compounds may be prepared by reacting a 4-haloquinazoline with bi-4-piperidyl or a bis(piperidyl-4)alkane.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: William R. J. Simpson
  • Patent number: 4011248
    Abstract: The present invention concerns a novel process for the purification of 1-nitroanthraquinone containing dinitroanthraquinone as impurity which comprises selectively converting the dinitroanthraquinone to an amino derivative by treatment of the mixture with ammonia, converting the resulting amino derivative to acid addition salt form, and separating the acid addition salt form of the amino derivative from the 1-nitroanthraquinone on the basis of their different polarities.
    Type: Grant
    Filed: December 1, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz Ltd.
    Inventor: Istvan Toth
  • Patent number: 4011339
    Abstract: The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4-positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as anti-inflammatory agents and hypolipidemic agents.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Faizulla G. Kathawala
  • Patent number: 4011340
    Abstract: Pivaloyl benzyl ureas, e.g., 1,1-bis(4-pivaloylbenzyl)-3-methyl urea, are prepared by reacting a corresponding 4", 4'"-iminodimethylene-di-tert. alkylophenones with an alkyl isocyanate, and are useful as hypolipidemic agents.
    Type: Grant
    Filed: October 28, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4011208
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is a benzene or naphthalene diazo component,R.sub.2 is cyano or acyl, andR.sub.3 is phenyl, naphthyl or heterocyclyl, or a substituted derivative thereof, with the proviso that the molecule is free of sulfo groups,Have low solubility in water and are highly suited for dyeing and printing fibers and textiles of synthetic and semi-synthetic, hydrophobic, high molecular weight polymers such as polyesters, cellulose diacetate, cellulose triacetate and polyamides. The obtained dyeings are fast to light, sublimation, thermofixation, pleating, wet treatments, etc. and are stable to permanent press finishing.
    Type: Grant
    Filed: September 11, 1974
    Date of Patent: March 8, 1977
    Assignee: Sandoz Ltd.
    Inventor: Hermann Burkhard
  • Patent number: 4011232
    Abstract: Phenoxyphenyl pyridyl carbinols and ketones, e.g., p-[4'-(2,2-dimethylpropyl)-phenoxy]-phenyl-(4-pyridyl)-carbinol, are useful as pharmaceutical agents. The ketones are obtainable by oxidation of corresponding phenoxyphenyl pyridyl carbinols.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: March 8, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4009189
    Abstract: Basic 4-alkylaminoanthraquinone dyes which bear a non-water-solubilizing substituent in the 2-position and in which the alkyl side-chain in the .alpha.-position to the anthraquinoneamino group is branched, which are useful for the exhaustion dyeing, pad dyeing and printing of textiles which consist wholly or partly of a polyacrylonitrile or acrylonitrile copolymer fiber.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: February 22, 1977
    Assignee: Sandoz Ltd.
    Inventor: Emilio Baserga
  • Patent number: 4009158
    Abstract: Compounds of the formula ##STR1## AND MIXTURES THEREOF, WHEREINE is phenyl, substituted phenyl, naphthyl, methylsulfonylnaphthyl, thiazolyl, substituted thiazolyl, benzothiazolyl, substituted benzothiazolyl, pyrazolyl, substituted pyrazolyl, 4-carbamoylimidazolyl, 4-phenyl-1,3,5-thiadiazolyl, thienyl, quinolyl or tetrazolyl,F is phenyl, naphthyl, thiazolyl, benzothiazolyl, pyrazolyl, imidazolyl, thiadiazolyl, thienyl, quinolyl, tetrazolyl or 1-anilino-1,3-dioxobutyryl-2, or a substituted derivative thereof,X is hydrogen, alkyl or substituted alkyl,m is 0 or 1, andn is 0 or 1,With the proviso that m + n is 1 or 2, and wherein Rings A, B and D may bear additional substituents.These compounds are outstandingly suitable for dyeing and printing fibres consisting of synthetic or semi-synthetic, hydrophobic organic compounds of high molecular weight and textile materials manufactured with these fibres.
    Type: Grant
    Filed: January 3, 1975
    Date of Patent: February 22, 1977
    Assignee: Sandoz Ltd.
    Inventor: Ruedi Altermatt
  • Patent number: 4008097
    Abstract: Disclosed are pigments, being co-condensate mixtures of compounds of formula I, ##STR1## wherein R.sub.1 is chlorine, bromine, fluorine, methyl, methoxy or ethoxy, preferably chlorine or methyl,R.sub.2 is hydrogen or has one of the significances of R.sub.1, preferably hydrogen, chlorine or methyl,At least two of the compounds in said mixture being present in an amount of at least 0.1 mol per mol of mixture.
    Type: Grant
    Filed: December 3, 1975
    Date of Patent: February 15, 1977
    Assignee: Sandoz Ltd.
    Inventors: Peter Bitterli, Fritz Kehrer
  • Patent number: 4008200
    Abstract: The present invention concerns a novel method of stabilizing organic material susceptible to degradation under the effect of heat, oxidation or ultra-violet light which comprises treating said material with a compound of the formula: ##STR1## WHEREIN R.sub.1, R.sub.2 and R.sub.3 are substituents, e.g. alkyl and Me is hydrogen or a metal cation.
    Type: Grant
    Filed: April 11, 1975
    Date of Patent: February 15, 1977
    Assignee: Sandoz Ltd.
    Inventors: Lajos Avar, Kurt Hofer, Martin Preiswerk
  • Patent number: 4008327
    Abstract: The compounds are cyclic acetals of 4'-(.alpha.-hydroxy-.alpha.-alkyl-p-tolyloxy)pivalophenones, e.g., ethylene glycol acetal of 4'-(.alpha.-hydroxy-.alpha.-heptadecyl-p-tolyloxy)pivalophenone, and are useful as anti-diabetic agents.
    Type: Grant
    Filed: June 16, 1975
    Date of Patent: February 15, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Patent number: 4007188
    Abstract: Disclosed are disperse dyes of formula I, ##STR1## in which X signifies O or NH, either R.sub.1 and R.sub.2 each signify an alkyl or phenyl radical,Or R.sub.1 is as defined above, and R.sub.2 is hydrogen,Or R.sub.1 and R.sub.2, together with the nitrogen atom, signify a heterocyclic ringR.sub.3 signifies acyl, alkyl, phenyl or a heterocyclic, andR.sub.4 signifies a chain forming a carbocyclic or heterocyclic ring of aromatic character.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: February 8, 1977
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch
  • Patent number: 4006131
    Abstract: Disclosed are water-soluble azo dyes of formula I, which are useful for dyeing substrates capable of being dyed by anionic dyes, particularly polyamides, paper and leather, ##STR1## in which the X's each signify a halogen atom, R.sub.1 signifies a hydrogen or halogen atom, or a nitro, hydroxy, --SO.sub.3 H, alkyl or alkoxy group, or an alkylated or acylated amino group, andR.sub.2 signifies a hydrogen atom or a hydroxy, alkyl, alkoxy or --SO.sub.3 H group.
    Type: Grant
    Filed: December 28, 1973
    Date of Patent: February 1, 1977
    Assignee: Sandoz Ltd.
    Inventor: Hanspeter Uehlinger
  • Patent number: 4006158
    Abstract: Polyester, cotton, polyamide and polyacrylonitrile fabrics and foils of polyvinylchloride are optically brightened by the addition of a compound of the formula ##STR1## in which each of R.sub.1 and R.sub.2 represents a hydrogen atom or an aliphatic, alicyclic, araliphatic, halogen- or alkyl-substituted araliphatic, aromatic, or halogen- or alkyl-substituted aromatic radical,OrR.sub.1 and R.sub.2 together with the two carbon atoms of the triazole ring form a five or six membered cycloalkyl ring or such a cycloalkyl ring having condensed on it a benzene ring,R.sub.3 represents a hydrogen or halogen atom or a low molecular weight alkyl or alkoxy radical.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: February 1, 1977
    Assignee: Sandoz Ltd.
    Inventors: Fritz Fleck, Hans Balzer, Horst Aebli
  • Patent number: 4006248
    Abstract: Alkyl-p-pivaloylbenzylaminomethyl-benzophenones, e.g., 4-{[methyl(p-pivaloylbenzyl)amino]methyl}benzophenone, are prepared by treating a corresponding 4-benzoyl-N-alkyl-benzylamine with a corresponding .alpha.-halo-p-pivaloyl toluene and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 21, 1975
    Date of Patent: February 1, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4006183
    Abstract: The invention discloses optionally substituted .alpha.-methylsulfinyl-o-toluidines having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting an optionally substituted .alpha.-methylthio-o-toluidine with an oxidizing agent.
    Type: Grant
    Filed: July 8, 1975
    Date of Patent: February 1, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Patent number: 4005069
    Abstract: The invention provides novel disperse dyes of formula I, ##STR1## in which D signifies the radical of a diazo component,Hal signifies chlorine or bromine,R.sub.2 signifies hydrogen, unsubstituted or substituted amino, or an unsubstituted or substituted hydrocarbon radical which may contain hetero atoms,AndR.sub.1 signifies cyano or a radical --COOR.sub.3 or --CONR.sub.4 R.sub.5, in which R.sub.3 signifies unsubstituted or substituted alkyl or phenyl, R.sub.4 signifies hydrogen, unsubstituted or substituted amino, or an unsubstituted or substituted hydrocarbon radical which may contain hetero atoms,And R.sub.5 signifies hydrogen or unsubstituted or substituted alkyl or phenyl,provided that the compounds contain no sulphonic acid radicals.These dyes are useful for dyeing and printing synthetic and semisynthetic high molecular weight hydrophobic fibers such as aromatic polyesters, synthetic polyamides, secondary cellulose acetate and cellulose triacetate.
    Type: Grant
    Filed: February 18, 1975
    Date of Patent: January 25, 1977
    Assignee: Sandoz Ltd.
    Inventor: Ulrich Zirngibl
  • Patent number: 4005067
    Abstract: By metallization of metallizable monoazo or azomethine dyes with cobalt-donating compounds in the presence of a nitrite, especially NaNO.sub.2, 1:1 cobalt complexes containing a nitrite ion are obtained in a high degree of metallization which can be reacted with metallizable monoazo or azomethine dyes to give very homogeneous 2:1 cobalt complexes in a high degree of purity. This is particularly advantageous when asymmetrical 2:1 cobalt complexes are to be prepared.
    Type: Grant
    Filed: June 2, 1975
    Date of Patent: January 25, 1977
    Assignee: Sandoz Ltd.
    Inventor: Jacky Dore
  • Patent number: 4005080
    Abstract: The present invention relates to compounds of formula I, ##STR1## in which R.sub.1 signifies a divalent, mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series,R.sub.2 signifies a hydrogen atom or an unsubstituted or substituted (C.sub.1-4)alkyl, phenyl, naphthyl or mono- or fused binuclear heterocyclic radical which is bound through a carbon atom, R.sub.3 signifies an oxygen atom or a group of formula >N--R.sub.5 in which R.sub.5 has one of the significances given above for R.sub.2, and each of the R.sub.4 's independently, signifies a mono- or binuclear aromatic radical of the carbocyclic or heterocyclic series,Or mixtures of such compounds, which compounds and mixtures are useful as colorants.
    Type: Grant
    Filed: November 26, 1974
    Date of Patent: January 25, 1977
    Assignee: Sandoz Ltd.
    Inventor: Werner Koch