Abstract: Disclosed herein are organic photosensitive optoelectronic devices comprising acceptor and/or donor sensitizers to increase absorption and photoresponse of the photoactive layers of the devices. In particular, devices herein include at least one acceptor layer and at least one donor layer, wherein the acceptor layer may comprise a mixture of an acceptor material and at least one sensitizer, and the donor layer may comprise a mixture of a donor material and at least one sensitizer. Methods of fabricating the organic photosensitive optoelectronic devices are also disclosed.

Abstract: Provided herein are methods and related devices for preprocessing a biological sample during transit. The method may comprise the steps of: storing a biological sample in a storage container having walls that defines a storage volume; transporting the storage container with the stored biological sample to a sample processing facility; controlling one or more storage container parameters during the transporting step to initiate preprocessing of the biological sample; wherein the controlling step improves a processing parameter at the sample processing facility.

Abstract: A mobility device may include a drive for driving the mobility device, a projector for outputting a visual stimulus, an electroencephalogram device for detecting a brainwave of a user, and a controller for controlling the drive and/or the projector. The controller may be connected to the EEG device, and may be configured to control the projector to output the visual stimulus to a surface at a position spaced by a specified distance from the mobility device.

Abstract: The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-ADPr, which directly reports on total PAR hydrolase activity via release of a fluorophore; this substrate has excellent reactivity, generality, stability, and usability. A second substrate, TFMU-IDPr, selectively reports on PARG activity only from the enzyme ARH3. Use of these probes in whole-cell lysate experiments has revealed a mechanism by which ARH3 is inhibited by cholera toxin. TFMU-ADPr and TFMU-IDPr are versatile tools for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes.

Abstract: A guidance unit comprises a first pipe part and a second pipe part, an inner space diameter of the second pipe part is smaller than an inner space diameter of the first pipe part, causing a cross-sectional area of a second flow space perpendicular to a pipe axis of the second pipe part smaller than that of a first flow space perpendicular to a pipe axis of the first pipe part; one end of the pipe axis of the second pipe part and one end of the pipe axis of the first pipe part are connected in series with each other and spaced apart from each other by a first angle, so that the second flow space communicates with the first flow space; thereby, a pressure of an external fluid in the second flow space is greater than a pressure of the external fluid in the first flow space.

Abstract: The present invention discloses a method for analysis of drug resistance of tumor cells. The method includes the steps of: (a) providing silicon dioxide nanoparticles, polystyrene-co-polyacrylic acid nanoparticles or metal-organic framework nanoparticles; (b) co-incubating the silicon dioxide nanoparticles, the polystyrene-co-polyacrylic acid nanoparticles or the metal-organic framework nanoparticles with the tumor cells; and (c) detecting endocytosis of the silicon dioxide nanoparticles, the polystyrene-co-polyacrylic acid nanoparticles or the metal-organic framework nanoparticles by the tumor cells. The analysis method of the present invention can analytically identify drug-resistant tumor cells in a clear, intuitive and efficient way. The provided nanoparticles feature simple synthesis processes that take short periods of time, and after they are co-incubated with the tumor cells, a flow cytometer is used for detection.

Abstract: A system and method for analyzing a plurality of tissue image samples at different stages of image processing in order to establish the level of fibrosis within a patient from which the tissue image sample was retrieved. Various embodiments incorporate machine learning techniques which enable an automated progressive approach to effectively and efficiently diagnosing fibrotic conditions based on tissue image samples.

Abstract: A method of anatomic classification of blood vessel anatomy in aneurysms includes the steps of accessing an image of a blood vessel, analyzing the image to identify a point of divergence of the blood vessel and one or more additional points of reference of the blood vessel. One or more distances are then measured between the point of divergence of the blood vessel and at least one of the one or more additional points of reference. The aneurysm is then classified based upon the measured distances. A method of treatment of an aneurysm in a blood vessel further includes implanting one or more devices within the blood vessel for treatment of the aneurysm.

Abstract: Exemplary apparatus can be provided that can comprise a plurality of antennas; a plurality of conversion systems, each capable of accepting and/or producing one or more digital signals; a circuit (e.g., radio circuit) configured to couple the antennas to the conversion systems; and computer arrangement configurable to selectively control operation of the conversion systems according to one or more predetermined criteria. In some embodiments, the conversion systems can be configured to utilize different sampling rates and/or quantization resolutions and/or to accept and/or produce different numbers of digital signals. Exemplary conversion systems can be enabled/disabled such that one or more can operate simultaneously based on, e.g., subframe timing of received signal, predetermined schedule, power or energy of s, availability of reference signals, channel coherence time, and apparatus energy consumption.

Abstract: A system for indexing, updating, and search haplotypes for genetic genealogical discovery in genotype databases. The system includes a pool of genetic indexes, a haplotype ingestion engine, and a haplotype query engine. The haplotypes of a number of individuals in a genotype database are indexed by a pool of multiple panels, and each panel pool can be dynamically updated by the insertion or deletion of individual haplotypes. A genetic genealogical search of a query haplotype against the database is achieved by first projecting the query onto a subset of panels in the pool, then conducting long match queries over each panel, and finally aggregating the identified long matches into Identical-by-Descent segments, i.e., DNA matches, between the query and the haplotypes in the database.

Abstract: In one aspect, a method of treating a subject having or at risk of having graft-versus-host disease (GvHD) generally includes administering to the subject a plurality of myeloid-derived suppressor cells (MDSCs) effective to ameliorate at least one symptom or clinical sign of graft-versus-host disease compared to a suitable control subject. In another aspect, a method of treating a tumor in a subject generally includes administering to the subject an anti-tumor therapy and co-administering to the subject an inflammasome inciting agent in an amount effective to increase inflammasome activation of MDSCs sufficiently to reduce suppressor function of the MDSCs.

Abstract: Optical tactile sensors are provided that include a scaffolding structure, a transparent elastomer material covering at least an end portion of the scaffolding structure, and one or multiple cameras situated on the end portion of the scaffolding structure and embedded within the transparent elastomer material, wherein the one or multiple cameras are situated so as to provide an extended, e.g., up to 360°, field of view about the end portion of the scaffolding structure.

Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.

Abstract: The invention provides a low-power wide area network integrated sensing and communication method based on channel sensing and reinforcement learning, and the method comprises the steps: receiving an uplink signal transmitted by a terminal node through a gateway receiver, demodulating the uplink signal through employing a soft demodulation algorithm, and obtaining a bit log-likelihood ratio; the deep reinforcement learning model completes channel reconstruction of the corresponding link during communication according to the bit log-likelihood ratio; and calculating the current optimal network configuration according to the reconstructed channel so as to distribute the current optimal network configuration to each terminal node during next downlink transmission.

Abstract: A system for improving radiation tolerance of memory senses an amount of radiation exposure and, based on the sensed amount of radiation exposure, determines whether to perform one or more techniques for mitigating the effects of the radiation exposure. As an example, the system may perform a data refresh operation by re-writing data that has been corrupted by radiation, or the system may adjust the reference voltage used to read memory cells. In another example, the system may perform a fault repair operation by re-programming cells that have erroneously transitioned from a program state to an erase state. The system may selectively perform different radiation-mitigation techniques in a tiered approach based on the sensed amount of radiation in order to limit the adverse effects of the more invasive techniques.

Abstract: The present disclosure is related to systems and methods to be used as aids in the diagnosis of risk for oral cancer, potentially malignant oral lesion (PMOL), and/or oral epithelial dysplasia (OED) by identifying cellular phenotype characteristics of cell samples, including percentage of mature squamous cells, presence or absence of nuclear actin in mature squamous cells, percentage of non-mature squamous cells, percentage of small round cells, percentage of white blood cells, and percentage of lone nuclei.

Abstract: A method of making a metal-polymer composite includes dealloying metallic powder to yield porous metal particles, monitoring a temperature of the mixture, controlling the rate of combining, a maximum temperature of the mixture, or both, and combining the porous metal particles with a polymer to yield a composite. Dealloying includes combining the metallic powder with an etchant to yield a mixture. A metal-polymer composite includes porous metal particles having an average particle size of about 0.2 ?m to about 500 ?m and a thermoplastic or thermoset polymer. The polymer composite comprises at least 10 vol % of the porous metal particles. A powder mixture includes porous metal particles having an average particle size of about 0.2 ?m to about 500 ?m and a metal powder. The powder mixture includes about 1 wt % to about 99 wt % of the porous metal particles.

Abstract: Provided herein are polymers having a polymer backbone including a zwitterionic precursor monomeric unit having a secondary or tertiary amine in the polymer backbone, as well as methods of making and using the same.

Abstract: A substantially cylindrical glass bottle that is susceptible to accidental rolling and breakage when stored on its side has been structurally modified by forming a series of between approximately 8 and 24 small protrusions or bumpers spaced apart at regular intervals along either one path or two separated paths around the bottle's circumference at certain distances from the shoulder and base of the bottle. The bumpers project outward between approximately 2 mm to 6 mm from the bottle's outer sidewall surface, and pairs of these bumpers stably support the bottle stored on its side without the bottle rocking or rolling.

Abstract: The present invention relates to methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs. Specifically, the disclosure provides methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs, the methods comprising administering to the subject a therapeutically effective amount of an isolated anti-HIV antibody, and administering to the subject two or more viral transcription inducers in effective amounts to induce transcription of an HIV provirus in the cells. Further provided are antibodies and viral transcription inducers used in the methods.