Defoaming composition
A defoaming or antifoaming composition comprises a free flowing granular combinate of 50 to 90 weight percent of a water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin agglomerates, maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids and about 10 to 50 weight percent of a liquid, nonaqueous, defoaming or antifoaming composition such as simethicone, hydrocarbon-based oils or silicone oils. The composition may be combined with one or more suitable excipients and prepared as a unit dosage in the form of a compressed tablet, filled capsule, packet, or granule for various defoaming applications.
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Claims
1. An antifoaming or defoaming composition consisting essentially of a dry, uniform, free flowing granular combinate of a water soluble carbohydrate-based agglomerate and a liquid, nonaqueous, antifoaming or defoaming composition selected from the group consisting of hydrocarbon-based oils containing silica, mineral oils containing silica and silicone oils containing silica.Iadd., wherein said carbohydrate-based agglomerate is selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids and agglomerates of corn syrup solids having a D.E. of at least 20.Iaddend..
3. The composition of claim 1 wherein said liquid antifoaming or defoaming composition is taken up by the agglomerated carbohydrate particles by sorption.
4. The composition of claim 1 wherein said combinate is comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
5. The composition of claim 1 wherein said combinate further includes one or more excipients.
6. The composition of claim 1 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
7. The composition of claim 1 wherein said liquid antifoaming or defoaming composition is a hydrocarbon-based oil containing silica.
8. The composition of claim 1 wherein said liquid antifoaming or defoaming composition is a mineral oil containing silica.
9. The composition of claim 1 wherein said liquid antifoaming or defoaming composition is a silicone oil containing silica.
10. An antifoaming or defoaming composition consisting essentially of a dry, uniform, free flowing granular combinate of at least about 50 weight percent water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerated sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E. of least 20, substantially having a particle size of less than about 850 microns and simethicone in an amount up to about 50 weight percent.
11. The composition of claim 10 wherein said simethicone is taken up by the agglomerated carbohydrate-based particles by sorption.
12. The composition of claim 10 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent simethicone.
13. The composition of claim 10 wherein said combinate further includes one or more excipients.
14. The composition of claim 10 wherein said combinate is prepared as a unit dose compressed tablet, capsule, or granule.
15. The composition of claim 10 wherein said water soluble carbohydrate-based agglomerate is selected from the group consisting of maltodextrin/dextrose co-agglomerates, maltodextrin/sucrose co-agglomerates, and maltodextrin/fructose co-agglomerates.
16. The composition of claim 10 wherein said water soluble carbohydrate-based agglomerate is selected from the group consisting of dextrose agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E. of at least 20.
17. A process for producing an antifoaming or defoaming combinate consisting essentially of mixing a water soluble carbohydrate-based agglomerate.Iadd.selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates sorbitol agglomerates, agglomerates of hydrolyzed cereal solids and agglomerates of corn syrup solids having a D.E. of at least 20,.Iaddend.with a liquid, nonaqueous, antifoaming or composition selected from the group consisting of hydrocarbon-based oils containing silica, mineral oils containing silica and silicone oils-containing silica to form a dry, uniform, free flowing granular combinate.
19. The process of claim 17 wherein said liquid antifoaming or defoaming composition is taken up by the carbohydrate-based agglomerate particles by sorption.
20. The process of claim 17 wherein said combinate is comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
21. The process of claim 17 further including the step of blending one or more excipients with said combinate.
22. The process of claim 17 comprising mixing about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
23. The process of claim 17 wherein said liquid antifoaming or defoaming composition is a hydrocarbon-based oil containing silica.
24. The process of claim 17 wherein said liquid antifoaming or defoaming composition is a mineral oil containing silica.
25. The process of claim 17 wherein said liquid antifoaming or defoaming composition is a silicone oil containing silica.
26. A process for producing an antifoaming or defoaming combinate consisting essentially of mixing at least about 50 weight percent of a water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E. of at least 20, substantially having a particle size of less than 850 microns with simethicone in an amount up to about 50 weight percent to form a dry, uniform, free flowing granular combinate.
27. The process of claim 26 wherein said simethicone is taken up by the carbohydrate-based agglomerate particles by sorption.
28. The process of claim 26 further including the step of blending one or more excipients with said combinate.
29. The process of claim 26 comprising mixing about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent simethicone.
30. The process of claim 26 further including the step of preparing said combinate as a unit dose compressed tablet, capsule, or granule.
31. The process of claim 26 wherein said water soluble carbohydrate-based agglomerate is selected from the group consisting of maltodextrin/dextrose co-agglomerates, maltodextrin/sucrose co-agglomerates, and maltodextrin/fructose co-agglomerates.
32. The process of claim 26 wherein said water soluble carbohydrate-based agglomerate is selected from the group consisting of dextrose agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E. of at least 20.
33. A method of defoaming an aqueous medium consisting essentially of contacting said aqueous medium with an antifoaming or defoaming composition comprising a dry, uniform, free flowing granular combinate of a water soluble carbohydrate-based agglomerate and a liquid, nonaqueous, antifoaming or defoaming composition selected from the group consisting of hydrocarbon-based oils and silicone oils in an amount up to about 50 weight percent of the composition.
35. A method of defoaming an aqueous medium consisting essentially of contacting said aqueous medium with an antifoaming or defoaming composition comprising a dry, uniform, free flowing granular combinate of at least about 50 weight percent water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E. of at least 20, substantially having a particle size of less than about 850 microns and simethicone in an amount up to about 50 weight percent.
36. The method of claim 35 wherein said combinate further includes one or more excipients.
37. The method of claim 35 wherein said combinate is in the form of a unit dose compressed tablet, capsule, or free flowing granules.
38. An antigas or antiflatulent treatment method consisting essentially of ingesting a unit dose of an antifoaming or defoaming composition comprising a dry, uniform, free flowing granular combinate of at least about 50 weight percent water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, dextrose agglomerates, maltodextrin/sucrose co-agglomerates, maltodextrin/fructose co-agglomerates, sucrose agglomerates, fructose agglomerates, mannitol agglomerates, sorbitol agglomerates, agglomerates of hydrolyzed cereal solids, and agglomerates of corn syrup solids having a D.E of at least 20, substantially having a particle size of less than about 850 microns and simethicone in an amount up to about 50 weight percent.
39. The composition of claim 1 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a silicone oil containing silica in an amount up to about 50 weight percent of the composition.
40. The composition of claim 1 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a hydrocarbon-based oil containing silica in an amount up to about 50 weight percent of the composition.
41. The process of claim 17 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a silicone oil containing silica in an amount up to about 50 weight percent of the composition.
42. The process of claim 17 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a hydrocarbon-based oil containing silica in an amount up to about 50 weight percent of the composition.
43. The method of claim 33 wherein said liquid, nonaqueous, antifoaming or defoaming composition is selected from the group consisting of hydrocarbon-based oils containing silica and silicone oils containing silica.
44. The method of claim 43 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a silicone oil containing silica.
45. The method of claim 43 wherein said liquid, nonaqueous, antifoaming or defoaming composition is a hydrocarbon-based oil, containing silica.
47. The composition of claim 46 wherein said combinate is comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
48. The composition of claim 46 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
49. An antifoaming or defoaming composition consisting essentially of a dry, uniform, free flowing granular combinate of at least about 50 weight percent water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, maltodextrin/sucrose co-agglomerates, and maltodextrin/fructose co-agglomerates, substantially having a particle size of less than about 850 microns and simethicone in an amount up to about 50 weight percent.
51. The process of claim 50 wherein said combinate is comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
52. The process of claim 51 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
53. A process for producing an antifoaming or defoaming combinate consisting essentially of mixing at least about 50 weight percent of a water soluble carbohydrate-based agglomerate selected from the group consisting of maltodextrin/dextrose co-agglomerates, maltodextrin/sucrose co-agglomerates, and maltodextrin/fructose co-agglomerates, substantially having a particle size of less than 850 microns with simethicone in an amount up to about 50 weight percent to form a dry, uniform, free flowing granular combinate.
55. The composition of claim 54 wherein said antifoaming or defoaming composition comprises silicone oil containing silica.
56. The composition of claim 54 wherein said combinate comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
57. The composition of claim 54 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
59. The process of claim 58 wherein said antifoaming or defoaming composition comprises silicone oil containing silica.
60. The process of claim 58 wherein said combinate is comprised of one or more carbohydrate-based agglomerates having a particle size of less than about 850 microns with a majority greater than about 420 microns.
61. The process of claim 58 comprising about 50 to 90 weight percent carbohydrate-based agglomerate and about 10 to 50 weight percent liquid antifoaming or defoaming composition.
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Type: Grant
Filed: Jan 18, 1995
Date of Patent: Sep 8, 1998
Assignee: Valentine Enterprises, Inc. (Lawrenceville, GA)
Inventors: William K. Valentine (Lawrenceville, GA), William Valentine (Lawrenceville, GA)
Primary Examiner: Thurman K. Page
Assistant Examiner: James M. Spear
Law Firm: Cushman Darby & Cushman IP Group of Pillsbury Madison & Sutro, LLP
Application Number: 8/374,224
International Classification: A61K 916; A61K 920; A61K 4726; A61K 31695;
