Sorption Testing Patents (Class 422/69)
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Publication number: 20140127730Abstract: The invention provides a method and system for developing and using diagnoses of one or more underlying health affections in humans or an animal specie using a plurality of biomarkers. A target one or more affections are defined and a set of biomarkers is selected. An index is computed based on the measured levels of the biomarkers. The biomarkers levels are discretized, and each discrete value is multiplied by a corresponding coefficient. The index scale is divided into ranges that are matched with health statuses. A subject's health affection status is subsequently determined by measuring the level of each biomarker in the set, computing the index and matching the index value to the predefined index scale.Type: ApplicationFiled: November 8, 2012Publication date: May 8, 2014Applicant: VETERINARY DIAGNOSTICS INSTITUTE, INC.Inventor: RANDY RINGOLD
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Publication number: 20140128293Abstract: Device to detect at least an analyte, comprising a transparent substrate (2), having a first surface (3) with which a light source (7) is associated, and a second surface (4) on which a plurality of biological protein probes (12) are disposed, a layer (6) of polymer being interposed between said second surface (4) and said biological protein probes (12). A marker (fluorophore) is associated with said analyte, having determinate characteristics of fluorescence and/or phosphorescence correlated to the emission wavelength of the light source (7). Said light source (7) is suitable to emit a light radiation in a range of wavelengths equal to 400-550 nm, inside which range the absorption peak of said marker (fluorophore) used is comprised. The value of the distance (“s”) between the wavelength corresponding to the absorption peak of the marker (fluorophore) and the wavelength corresponding to the emission peak of fluorescence (phosphorescence) is comprised between 25 and 150 nm.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: OR-EL ORGANSKA ELEKTRONIKA D.O.O.Inventor: Patrizia MELPIGNANO
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Publication number: 20140127713Abstract: The invention provides means for making examinations on a sample of body fluid, particularly a sample of blood. The presence of at least one characteristic protein is additionally detected, and the intended examinations are only executed and/or evaluated if said characteristic protein is present. The characteristic protein may for example be human serum albumin or hemoglobin if the body fluid is blood. Preferably, the characteristic protein is quantitatively detected in a competitive assay performed in a cartridge (110) with the help of a sensor device (150).Type: ApplicationFiled: June 4, 2012Publication date: May 8, 2014Inventors: Femke Karina De Theije, Albert Hendrik Jan Immink, Lian Van Lippen, Franka Maria Diny Couwenberg
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Publication number: 20140128278Abstract: The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.Type: ApplicationFiled: March 14, 2012Publication date: May 8, 2014Applicant: YALE UNIVERSITYInventors: Tarek M. Fahmy, Aleksandar Vacie, Mark A. Reed
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Publication number: 20140127828Abstract: The present invention related to a reaction vessel, an assay device and a measuring method. A reaction vessel includes a casing, a reagent and at least one individual element. The casing includes an opening and a detection zone. The opening may be formed on the edge of the casing and used to introduce a sample included an analyte. The detection zone is used to detect the analyte in the sample. The reagent is interacted with the sample. The individual element provides space and flow channel for mixing the sample and the reagent. The sample and the reagent are mixed in the individual element so as to determine the analyte in the detection zone, and thereby increasing accuracy of analyte detection.Type: ApplicationFiled: November 6, 2013Publication date: May 8, 2014Applicant: TAIDOC TECHNOLOGY CORPORATIONInventors: Hui-Sheng Hou, Pin-Hsun Huang, Chia-Chi Wu
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Publication number: 20140128288Abstract: A sensor device has an arrangement of plural sensors for sensing an analyte which is in at least one of liquid phase or a suspension or a gel. Each sensor includes a nano-electrode and is configured to sense the presence of a particle localized to or bound to the nano-electrode. The sensor is configured to discriminate in real-time the binding of particles to respective nano-electrodes.Type: ApplicationFiled: April 10, 2013Publication date: May 8, 2014Applicant: NXP B.V.Inventor: Franciscus Petrus WIDDERSHOVEN
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Publication number: 20140127829Abstract: An optical device has a deformable solid substrate, and a two dimensional array of metal particles which is carried by the substrate. The array provides a controlled separation between nearest-neighbour particles. Deformation of the substrate produces corresponding variation in the controlled separation such that the two dimensional array undergoes a transition between metallic and insulator surface reflectance.Type: ApplicationFiled: May 16, 2012Publication date: May 8, 2014Applicant: Cambridge Enterprise LimitedInventors: Jeremy Baumberg, Fumin Huang, Matthew Millyard
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Publication number: 20140120631Abstract: A protein detection device and method. The device has a main channel in which is attached either a polar rail molecule or a biomolecular motor which moves on the rail molecule in a direction corresponding to the polarity of the rail molecule. A sub-channel crosses the main channel for receiving a sample including tau-protein. The method includes feeding the sample to the device and detecting a ratio of mutated tau-protein included in the sample, based on motion of the biomolecular motor on the rail molecule or on motion of the rail molecule moved by action of the biomolecular motor.Type: ApplicationFiled: June 3, 2012Publication date: May 1, 2014Applicant: THE FOUNDATION FOR THE PROMOTIOM OF INDUSTRIAL SCIENCEInventors: Hiroyuki Fujita, Mehmet Cagatay Tarhan, Ryuji Yokokawa, Stanislav L. Karsten
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Publication number: 20140119995Abstract: This invention relates to a device for detecting an analyte in a sample comprising: a radiation source adapted to generate a series of pulses of electromagnetic radiation; a transducer having a pyroelectric or piezoelectric element and electrodes which is capable of transducing energy generated by non-radiative decay into an electrical signal; a detector which is capable of detecting the electrical signal generated by the transducer; a first reagent proximal to the transducer, the first reagent having a binding site which is capable of binding a labelled reagent proportionally to the concentration of the analyte in the sample, which labelled reagent being capable of absorbing the electromagnetic radiation generated by the radiation source to generate energy by non-radiative decay; a second reagent proximal to the transducer, the second reagent having a lower affinity for the labelled reagent under the conditions of the assay than the first reagent; and a third reagent proximal to the transducer, the third reaType: ApplicationFiled: April 5, 2012Publication date: May 1, 2014Applicant: Vivacta LimitedInventors: Steve Ross, Julie Richards, Tim Carter
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Publication number: 20140120633Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.Type: ApplicationFiled: January 6, 2014Publication date: May 1, 2014Applicant: CARNEGIE MELLON UNIVERSITYInventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
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Publication number: 20140113384Abstract: Lateral flow immunoassay devices for determining the concentration of an analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow immunoassay devices.Type: ApplicationFiled: October 23, 2012Publication date: April 24, 2014Applicant: Robert Bosch GmbHInventors: Sam KAVUSI, Frederik Kotz
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Publication number: 20140113303Abstract: The described embodiments may provide a method of fabricating a chemical detection device. The method may comprise forming a microwell above a CMOS device. The microwell may comprise a bottom surface and sidewalls. The method may further comprise applying a first chemical to be selectively attached to the bottom surface of the microwell, forming a metal oxide layer on the sidewalls of the microwell, and applying a second chemical to be selectively attached to the sidewalls of the microwell. The second chemical may lack an affinity to the first chemical.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Wolfgang HINZ, John M. MAURO, Shifeng LI, James BUSTILLO
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Publication number: 20140113386Abstract: Embodiments of the disclosure are directed to a device for molecule sensing. In some embodiments, the device includes a first electrode separated from a second electrode by a dielectric layer. The first electrode comprises a large area electrode and the second electrode comprises a small area electrode. At least one opening (e.g., trench) cut or otherwise created into the dielectric layer exposes a tunnel junction therebetween whereby target molecules in solution can bind across the tunnel junction.Type: ApplicationFiled: October 10, 2013Publication date: April 24, 2014Applicant: ARIZONA BOARD OF REGENTS, acting for and on behalf of ARIZONA STATE UNIVERSITYInventors: Brett Gyarfas, Stuart Lindsay, Pei Pang
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Publication number: 20140113840Abstract: Methods and systems for detecting analytes using a sensor element having a cleaning cycle and renewable liquid material with an affinity for the analytes are described. An analyte detection system may include a controller in communication with a sensor element and a liquid dispensing assembly. The liquid dispensing assembly, such as an inkjet dispensing device, may deposit the liquid material on or adjacent to the sensor element. The controller may be operative to monitor at least one property associated with the liquid material deposited on the sensor element. In addition, the controller may be configured to generate at least one control signal based on the at least one property. The liquid dispensing assembly may be configured to deposit the at least one liquid material on the sensor element based on the at least one control signal.Type: ApplicationFiled: October 19, 2012Publication date: April 24, 2014Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventors: Mordehai Margalit, Gil Perlberg
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Patent number: 8703058Abstract: Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.Type: GrantFiled: September 9, 2009Date of Patent: April 22, 2014Assignee: Sandia CorporationInventors: Anson V. Hatch, Gregory J. Sommer, Anup K. Singh, Ying-Chih Wang, Vinay V. Abhyankar
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Publication number: 20140106346Abstract: Apparatus for determining the quantity of a target protein, biomarker or analyte present in a sample, comprising a top plate and a bottom plate, each comprising a plurality of recesses arranged to form a plurality of rows extending parallel to one another, and a plurality of channels extending perpendicularly to the plurality of rows of the bottom plate; wherein the top plate and the bottom plate are assembled together so that the top plate is on top of the bottom plate and the recesses of the top plate communicate with the recesses of the bottom plate so as to form a plurality of rows; and wherein at least one of the top and bottom plate is configured to slide relative to the other of the top and bottom plate in order to form a plurality of columns, with each of the columns in communication with each of the channels.Type: ApplicationFiled: March 15, 2013Publication date: April 17, 2014Inventors: Lidong Qin, Yujun Song
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Publication number: 20140106470Abstract: Provided among other things is an analyzer for use with tabs placed in a vessel comprising: a stochastic sampling device adapted to receive the vessel; a light beam source adapted to enter the moving vessel and selectively illuminate tabs; an analytical signal receiver adapted to receive a signal indicative of an analytical process occurring on the surface of the tab as the tab is selectively illuminated; a tab ID receiver adapted to collect ID data from the tabs in coordination with their selective illumination; and a controller for associating identified tabs with analytical signals.Type: ApplicationFiled: October 15, 2013Publication date: April 17, 2014Applicant: PharmaSeq, Inc.Inventors: Wesley Kopacka, Wlodek Mandecki, Richard Morris
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Publication number: 20140106441Abstract: Methods, systems, devices and materials are disclosed for implementing a bioaffinity sensor having a self-assembled monolayer interface for detection of a target molecule. In one aspect, a sensor device for detecting a target molecule includes a surface capable of attaching a thiol and a molecular monolayer formed on the surface that includes a molecular capture probe having a thiol region, a linear alkanethiol molecule having one thiol region, and a linear alkanedithiol molecule having two thiol regions, in which the molecular capture probe includes a region for receiving a target substance having a complimentary region that couples with the region of the molecular capture probe to generate a detectable signal.Type: ApplicationFiled: January 27, 2012Publication date: April 17, 2014Inventors: Joseph Wang, Susana Campuzano-Ruiz
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Publication number: 20140106468Abstract: Optical sensor for detecting an analyte (4), the sensor comprising a photonic crystal, the photonic crystal comprising an analyte—sensitive polymeric material (1) which material is deformable by contact with said analyte (1), by which contact an optical property of the photonic crystal is altered or of which material (1) a refractive index is changed by contact with said analyte (4) and which analyte—sensitive material (1) forms part of a periodic structure (3,4) of the photonic crystal, the structure (3,4) having alternating zones of a relatively high refractive index and zones of a relatively low refractive index, which alternating zone are provided in one or two orthogonal directions of the analyte—sensitive material (1).Type: ApplicationFiled: March 13, 2012Publication date: April 17, 2014Inventor: Arjen Boersma
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Publication number: 20140106472Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.Type: ApplicationFiled: April 11, 2012Publication date: April 17, 2014Applicant: ELECTRONIC BIOSCIENCES, INC.Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
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Publication number: 20140106466Abstract: A method of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette, and a test element made in accordance with the method.Type: ApplicationFiled: October 16, 2012Publication date: April 17, 2014Applicant: Ortho-Clinical Diagnostics, Inc.Inventors: Jonathan Burr Crowther, Amy Louise Surowitz, Anna Krystyna Luczak
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Publication number: 20140106368Abstract: The present invention is generally directed to a fluidized bed detector for continuous detection of biological and chemical materials comprising a fluidized bed of detecting elements suspended in a continuous flow system wherein the detecting elements remain in the system when a first force trying to move the detecting elements to the bottom of the system is balanced with a second opposing force of a flowing gas or liquid trying to move detecting elements to the top of the system and wherein the presence of a target molecule in the flowing gas or liquid disrupts the balance of the first and second forces causing the detecting element to exit the system. The release of the detecting element indicates the presence of the target molecule and may be captured, concentrated, or both for further evaluation by other assays or other means. Also disclosed is the related method of detecting biological and chemical materials using a fluidized bed detector.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Inventor: David A. Kidwell
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Publication number: 20140099732Abstract: Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars extending through the metallic layer. A plurality of regions of concentrated light can be supported in proximity to the ends of the plurality of dielectric pillars when a surface of the metallic layer is illuminated. Concentrated light within one or more of these regions can interact with an analyte molecule, allowing for detection of the analyte.Type: ApplicationFiled: October 4, 2013Publication date: April 10, 2014Inventors: Sameer Sudhir Walavalkar, Andrew Peter Homyk, William Maxwell Jones, Axel Scherer, Scott Fraser, Thai Viet Truong
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Publication number: 20140099265Abstract: The invention relates to a method and apparatus for pre-hatch avian embryo sex determination. In particular, the invention relates to a non-invasive method and apparatus for in-ovo determining the sex of avian species while in the egg and allowing to sort the eggs into groups consisting primarily of either male or female embryos. The method comprises the steps of introducing into the egg an antibody designed to match with a sex specific antigen on the embryo, which antibody is labelled, allowing the labelled antibody to migrate to and bind with the sex specific antigen on the embryo, detecting binding of the labelled antibodies on the embryo using detection means positioned outside of the egg.Type: ApplicationFiled: December 10, 2013Publication date: April 10, 2014Applicant: VAN DE VEN BEHEER B.V.Inventors: Eddy DECUYPERE, Frank FEY
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Publication number: 20140099236Abstract: A microchip solution sending system may include a flow passage assembly that is at least provided with a fine flow passage that is provided with a detection region including a formed reaction field to which an antibody that reacts with a specific antigen is fixed; and a micro pump that is connected to the flow passage assembly and that is configured to send a specimen material solution that includes the specific antigen in a reciprocating manner.Type: ApplicationFiled: May 8, 2012Publication date: April 10, 2014Applicant: KONICA MINOLTA, INC.Inventors: Noriaki Yamamoto, Youichi Aoki
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Publication number: 20140093975Abstract: An automatic analyzer includes a reaction unit configured for holding a reaction container and carrying the reaction container to a determined operation position, the operation position including a detection operation position; a detection unit configured for detecting analyte in the reaction container of the reaction unit in the detection operation position; a bound-free (“B/F”) unit configured for removing unbound components of a reaction system; and a dispensing unit configured for dispensing reagent and/or a sample to the reaction container, wherein the reaction unit includes an incubation position for incubating a solution in the reaction container.Type: ApplicationFiled: September 25, 2013Publication date: April 3, 2014Inventors: Hai Wang, Zhen Zhang, Jun Wang, Peng Zhou
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Publication number: 20140093979Abstract: An apparatus and method for detecting an analyte are described. The apparatus includes at least one microchannel adapted for an analyte to adhere to an interior surface thereof, a mixing element positioned within at least a portion of the at least one microchannel, a light source for energizing quantum dots conjugated with the analyte within the at least one microchannel, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, wherein each wavelength range being correlated to one and only one type of analyte.Type: ApplicationFiled: October 1, 2013Publication date: April 3, 2014Applicant: Drexel UniversityInventors: Elisabeth Papazoglou, Hongseok Noh, Chengjie Yu, Peter M. Clark
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Publication number: 20140093949Abstract: The present invention provides systems and methods for analyzing the excitation spectra of fluorescent particles in a flowing stream. The system uses a white light laser and color separation optics to provide a spatially-distributed, continuous color-spectrum excitation light system that is used to illuminate a region of a flowing stream. A particle that passes through the detection region traverses the full dispersed spectrum of excitation light, and the fluorescence emissions from the particle are continuously measured as it passes through the detection region. The measured fluorescence emissions at each wavelength of excitation light, which changes through full spectrum of the excitation light as the particle passes through the detection region, provides the excitation spectrum of the particle.Type: ApplicationFiled: May 31, 2012Publication date: April 3, 2014Applicant: BECTON, DICKINSON AND COMPANYInventors: Pierce O. Norton, Yong Qin Chen
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Publication number: 20140093977Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
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Publication number: 20140093891Abstract: A device for performing a biochemical analysis, especially in outer space, more particularly an immunoassay, in which analysis at least one analyte in a sample is determined selectively, having at least one reaction container which has at least one work volume which is intended for taking in a liquid volume and for performing at least one substep of an analysis reaction, and having at least one interface which is intended for connecting at least one work volume to a further media container.Type: ApplicationFiled: September 17, 2013Publication date: April 3, 2014Applicant: Astrium GmbHInventors: Peter KERN, Jessica JANSON, Crispin SZYDZIK
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Publication number: 20140093428Abstract: The present invention relates to a device for performing an immunoassay, the device including a) a support, b) a porous matrix, fixed on the support, the matrix including (i) a liquid sample application area, (ii) a labeling area and (iii) at least one reaction area which includes a test results display area and a verification area, said liquid sample application area labeling area and reaction area being in fluid communication; the device including, at the verification area, at least a part of the porous matrix has pores with dimensions smaller than those of the labeled particles, such that at least a proportion of the labeled particles from the labeling area is stopped at said verification area forming a symbol which is visible or displayable for a user; and a method for manufacturing the device.Type: ApplicationFiled: June 4, 2012Publication date: April 3, 2014Applicant: BIOMERIEUX S.A.Inventors: Hélène Briand, Bruno Colin, Cécile Paris
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Publication number: 20140093865Abstract: Methods of determining whether an analyte is present in a sample using a competitive assay are provided. Aspects of the methods include employing a competitor that provides for the obtainment of signal which is directly proportional to the amount of analyte in the sample. Also provided are devices and kits that find use in practicing the methods described herein.Type: ApplicationFiled: September 10, 2013Publication date: April 3, 2014Inventors: Eric Espinosa, Andrew Farmer
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Publication number: 20140093427Abstract: Disclosed is an assay device comprising liquid transport means adapted to take up a liquid sample and conduct the liquid to an analyte detection region operable to provide a test signal indicative of the presence and/or amount of an analyte in the liquid sample; the assay device further comprising a sample presence signal generation means, which is not generated by means of immunoreaction. This sample presence signal generation means can comprise a coloured portion, which is overlaid by a material (e.g. nitrocellulose) that is opaque, when dry, and translucent or transparent, when wet, to allow the coloured portion to become visible to the user. In another embodiment the signal generation means comprises a colour changing material which under-goes a change in its visible properties upon wetting (eg. pH indication). A third embodiment uses a mobilisable detectable which, when wetted by the sample, is carried along resulting in a streaked line parallel with the flow direction.Type: ApplicationFiled: May 17, 2013Publication date: April 3, 2014Applicant: Alere Switzerland GmbHInventors: Barry Sinclair Brewster, Adrian Leslie Walker, Robert John Davies
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Publication number: 20140093980Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a source configured to receive one or more fluids, a first material adjacent to and in fluid connection with the source, a second material, and a dissolvable volume-metering element positioned between the first material and the second material. The volume-metering element can be configured to provide a fluid connection between the first material and the second material. The volume-metering element can also be configured to at least partially dissolve and break the fluid connection between the first material and second material once a predetermined volume of fluid flows therethrough.Type: ApplicationFiled: October 1, 2013Publication date: April 3, 2014Inventors: Elain S. Fu, Barry Lutz, Jared Houghtaling, Tinny Liang
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Publication number: 20140087398Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.Type: ApplicationFiled: November 13, 2013Publication date: March 27, 2014Applicants: Arlington Scientific, Inc., Government of the U.S.A. as Represented by the Secretary of the Dept. of Health and Human ServiceInventors: Arnold R. Castro, Himanshu Champaklal Mody
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Publication number: 20140087365Abstract: An object of the present invention is to provide an immunochromatographic detection method comprising a step of detecting the failure to add a specimen and an immunochromatographic test strip comprising a means for detecting the failure to add a specimen. The inventers provides an immunochromatographic detection method and an immunochromatographic test strip capable of detecting the failure to add a specimen through a step and a means using an antibody solid-phased on an insoluble membrane for capturing the complex of a component (control component) contained in the specimen other than the analyte and a label to which an antibody to the component is immobilized so as to detect the presence or absence of the control component, in an immunochromatographic detection method of detecting an analyte in a sample acquired by diluting the specimen.Type: ApplicationFiled: March 29, 2012Publication date: March 27, 2014Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Motoki Morita, Koji Kobayashi, Sachiko Ito
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Publication number: 20140087452Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.Type: ApplicationFiled: September 26, 2012Publication date: March 27, 2014Inventors: Zenghe Liu, James Etzkorn
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Publication number: 20140079592Abstract: A bio-nanowire device includes a substrate having a first surface, a first conductor, a second conductor, and a bio-nanowire. The first and second conductors are disposed on the first surface of the substrate, and are spaced apart from each other. The bio-nanowire has two ends respectively connected to the first and second conductors, and includes a nucleic acid molecule having two nucleotide segments, and a plurality of metal ions bonded between the two nucleotide segments of the nucleic acid molecule. The two nucleotide segments form a double helix structure via base pairs. When a voltage or a current is applied to the bio-nanowire, the oxidation state of the metal ions can be changed such that the non-linear electroconductive characteristic of the bio-nanowire can be controlled.Type: ApplicationFiled: September 18, 2013Publication date: March 20, 2014Applicant: National Chiao Tung UniversityInventors: Chia-Ching Chang, Wen-Bin Jian, Yu-Chang Chen, Chiun-Jye Yuan, Frank Gu
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Publication number: 20140080203Abstract: Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.Type: ApplicationFiled: September 17, 2013Publication date: March 20, 2014Applicant: MicroPoint Bioscience Inc.Inventors: Zhiliang Wan, Nan Zhang
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Patent number: 8673651Abstract: A package for holding and disguising a chromatographic test of food and drink is formed in the shape of a drinking straw or stirrer. The package encloses test patches which are sensitive to particular drugs and produce a color change upon contact with the drug. The package has a view port or slit to observe the condition of the test strip upon contact with food and drink.Type: GrantFiled: November 3, 2005Date of Patent: March 18, 2014Assignee: GelTech Solutions, Inc.Inventors: Peter Cordani, Anne Cordani
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Publication number: 20140072959Abstract: The present invention relates to rapid test devices, kits and systems comprising the rapid test devices for assessing at least two analytes in a sample derived from a life or health insurance applicant, said at least two analytes being selected from the group consisting of a human immunodeficiency virus (HIV) antigen (e.g., a HIV polypeptide), a HIV polynucleotide, an anti-HIV antibody, a hepatitis C virus (HCV) antigen (e.g., a HCV polypeptide), a HCV polynucleotide, an anti-HCV antibody, a liver enzyme alanine transaminase (ALT), a liver enzyme aspartate transaminase (AST), nt-probnp (or NT-proBNP), probnp (or proBNP), cotinine, nicotine, cocaine, a metabolite of cocaine (e.g., benzoylecgonine), prostate-specific antigen (PSA), apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB), Hemoglobin A1c and high-sensitivity C-reactive protein (hsCRP).Type: ApplicationFiled: March 14, 2013Publication date: March 13, 2014Applicant: FORCE DIAGNOSTICS, INC.Inventors: Tedd C. DETERMAN, Michael P. CURRAN, Brian MULCONREY, David H. OSTROW
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Publication number: 20140073039Abstract: The present disclosure provides a biological field effect transistor (BioFET) and a method of fabricating a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a plurality of micro wells having a sensing gate bottom and a number of stacked well portions. A bottom surface area of a well portion is different from a top surface area of a well portion directly below. The micro wells are formed by multiple etching operations through different materials, including a sacrificial plug, to expose the sensing gate without plasma induced damage.Type: ApplicationFiled: September 8, 2012Publication date: March 13, 2014Applicant: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.Inventors: Yi-Hsien Chang, Chun-Ren Cheng, Shih-Wei Lin, Yi-Shao Liu
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Publication number: 20140072960Abstract: A test unit collects and analyzes biological specimens on-site. It has one or more openings that allow reagent capsules to be inserted and guided into a testing chamber. Reagent capsules are preloaded with chemicals for screening and are configured as blister packs. A button mechanism allows projection(s) to open the blister packs to allow chemicals within the capsules to mix inside the testing chamber. A medical swab is affixed to a pop top dispenser cap and can be pressed to allow the swab to be inserted into the mixed chemicals. A visible test strip mount attached to the testing chamber has a lever to manipulate a test strip in and out of the testing chamber. This test strip may be slid through a uni-directional seal on a capsule and into a chemical for testing. The test strip will test for the presence of an infectious disease.Type: ApplicationFiled: May 31, 2013Publication date: March 13, 2014Inventor: Bliss Hanlon Lansing
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Patent number: 8668871Abstract: Provided are a sensing device and a biosensor that are capable of achieving stable performance in sensing saccharides or hydroxyl group-containing polymers, and that can be stored for a long time. The biosensor 8 of the present invention uses, as a component for sensing glucose, a sensing device 16 in which a completely synthetic phenylboronic acid compound 21 is bound without using enzymes that have been conventionally used. Consequently, the biosensor 8 can eliminate the problem of protein denaturation to achieve stable performance in sensing glucose, and it is possible to achieve the biosensor 8 can be stored for a long time.Type: GrantFiled: July 20, 2011Date of Patent: March 11, 2014Assignee: National Institute for Materials ScienceInventors: Akira Matsumoto, Yuji Miyahara
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Publication number: 20140065648Abstract: Methods and systems for diagnosing functional and/or structural abnormalities of the heart preceding heart failure, and for predicting the risk of developing heart failure, in a subject comprising measuring a cardiac troponin in a sample and comparing the measurement to a reference value. Other markers, including GDF15 and IGFBP7 are also measured in some embodiments.Type: ApplicationFiled: February 25, 2013Publication date: March 6, 2014Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Ursula-Henrike Wienhues-Thelen, Dirk Block, Hendrik Heudig, Sabine Vogel-Ziebolz, Christine Boehm, Georg Hess, Andrea Horsch, Dietmar Zdunek
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Publication number: 20140065640Abstract: This invention provides methods and systems for detecting interaction between members of a binding pair. The method involves associating one member of the binding pair with a nanoparticle and detecting the interaction between the two molecules by back-scattering interferometry.Type: ApplicationFiled: May 2, 2013Publication date: March 6, 2014Applicants: Vanderbilt University, Molecular Sensing, Inc.Inventors: Scot Weinberger, William E. Rich, Stephen Dotson, Darryl J. Bornhop
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Publication number: 20140057301Abstract: Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: ApplicationFiled: August 20, 2013Publication date: February 27, 2014Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
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Publication number: 20140057300Abstract: Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: ApplicationFiled: August 20, 2013Publication date: February 27, 2014Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Ronghui Lin
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Publication number: 20140057299Abstract: Disclosed is an antibody which binds to aripiprazole, which can be used to detect aripiprazole in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of aripiprazole, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.Type: ApplicationFiled: August 20, 2013Publication date: February 27, 2014Inventors: Eric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Bart M. Remmerie, Rhys Salter, Ronghui Lin
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Publication number: 20140057366Abstract: The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR).Type: ApplicationFiled: November 28, 2011Publication date: February 27, 2014Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Wendy Uyen Dittmer, Mikhail Mikhaylovich Ovsyanko, Toon Hendrik Evers, Jeroen Hans Nieuwenhuis, Joannes Baptist Adrianus dionisius Van Zon