Abstract: The present disclosure relates to implants with a biocompatible coating having antithrombogenic properties and which also contains a pharmacologically active agent, as well as a process for their production.

Abstract: This invention relates to a method comprising contacting a microorganism and/or an infectious agent with an effective amount of a polymer composition to reduce or eliminate the reproductivity, metabolism, growth and/or pathogenicity of the microorganism and/or infectious agent, the polymer composition comprising water, a water-soluble film forming polymer, a chelating agent, and a surfactant.

Abstract: A personal cleansing composition comprising: a. from about 5% to about 50% by weight of an anionic detersive surfactant; b. from about 0.025% to about 5% by weight of a first cationic polymer having a cationic charge density of less than about 4 meq/gm, wherein said first cationic polymer forms an isotropic coacervate; c. from about 0.025% to about 5% by weight of a second cationic polymer having a cationic charge density of greater than or equal to about 4 meq/gm, wherein said second cationic polymer forms a lyotropic liquid crystal coacervate; and d. from about 20% to about 94% by weight of water.

Abstract: Dendrimers comprising N-acyl urea terminal moieties are described herein. The dendrimers can be used, for example, in the treatment of arthritis.

Abstract: The present invention refers to novel conjugate molecules and their use or the transport of nano- and macromolecular structures into cells and/or the nucleus. More particularly, the present invention refers to conjugate molecules containing a carrier, preferably thiopyridyl moieties, and a cargo moiety. Thereby, the thiopyridyl moiety is bound to the cargo moiety to act as a carrier, particularly for efficient intracellular and/or intranuclear delivery of drugs, nano-or macromolecular structures, etc. The novel conjugate molecules are provided for the manufacture of a medicament for gene therapy, apoptosis, or for the treatment of diseases such as cancer, autoimmune diseases or infectious diseases.

Abstract: The present invention is directed to a cosmetic composition containing: (a) at least one propylphenylsilsesquioxane resin; (b) at least one cosmetically-acceptable aromatic solvent; (c) at least one colorant, and (d) optionally, at least one co-solvent, and wherein the composition is substantially free of volatile solvents. Also disclosed is a method of imparting lasting shine onto lips by contacting the lips with the above described composition.

Abstract: Complexes of ibuprofen and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the complexes were stably retained in the wood providing a long lasting preservative.

Abstract: The present invention provides an external composition for skin that has excellent effects in improving elasticity and alleviating wrinkles while moisturizing the skin, has good spreadability on the skin, and has no stickiness. The external composition for skin of the present invention is characterized by comprising: (A) an acrylic polymer comprising the following monomers (a1), (a2), and (a3) as constituent monomers: (a1) acrylic acid or methacrylic acid; (a2) an alkyl acrylate or alkyl methacrylate; and (a3) an ester between acrylic acid or methacrylic acid and polyoxyethylene alkyl ether; and (B) a cross-linked polyamino acid or its salt. In the external composition for skin of the present invention, it is preferable that (A) is 0.01 to 10.0 weight % as a polymer, and (B) is 0.0001 to 5.0 weight % as a polymer.

Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.

Abstract: The present invention relates to a method for determining variable response to statin therapy in patients afflicted with or susceptible to develop cardiovascular diseases, hypercholesterolemia, Diabetes and metabolic disorders involving high baseline plasma lipid level such as high LDL-C level, comprising detecting the presence or absence of the Pro 155T hr (C463A) variant in the Organic Anion Transporting Polypeptide-C(OATP-C) gene, wherein the presence of said variant is indicative of superior response to statin therapy. It also concerns tailored treatment of different populations of patients according to the Pro155Thr (C463A) variant genotype.

Abstract: Various polymers, including cationic polyamine polymers and dendrimeric polymers, are shown to possess anti-proliferative activity, and may therefore be useful for treatment of disorders characterised by undesirable cellular proliferation such as neoplasms and tumours, inflammatory disorders (including autoimmune disorders), psoriasis and atherosclerosis. The polymers may be used alone as active agents, or as delivery vehicles for other therapeutic agents, such as drug molecules or nucleic acids for gene therapy. In such cases, the polymers' own intrinsic anti-tumour activity may complement the activity of the agent to be delivered.

Abstract: Functionalized prepolymers and biocompatible polymer networks are disclosed, especially biodegradable polymer networks obtainable by polymerization of the functionalized prepolymers by for example ultraviolet (UV), redox, and/or heat radical polymerization. Functionalized prepolymers (macromers) are obtainable by reaction of a prepolymer comprising at least one alcohol, amine, and/or sulfhydril group, with an unsaturated mono-esterified dicarbonic acid, especially fumaric acid mono-ethyl ester.

Abstract: A skin care composition for regulating sebum flow from sebocytes is described. The composition comprises spheroids, and optionally, thickening agents and when a spheroid and sebum mixture is made upon application, the resulting mixture leaves a pleasant, silky and powdery sensation.

Abstract: A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from a spray bottle into the ostomy bag and retained on the inner walls thereof without being displaced therefrom by incoming waste during use of the ostomy bag. This allows the composition to continue to deodorize the ostomy bag headspace even after waste material begins to fill the bag.

Abstract: Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages.

Abstract: Polymers (i.e. polyesters, polyamides, and polythioesters or a mixture thereof) which degrade hydrolytically into biologically active compounds are provided. Methods of producing these polymers, intermediates useful for preparing these polymers, and methods of using these polymers to deliver biologically active compounds to a host are also provided.

Abstract: A process for manufacturing polymers of glycerin and hydroxyl fatty acids, for example, polyglycerol polyricinoleates, which mix a polyglycerol with a hydroxyl fatty acid directly to form a reaction mixture, and then heat the reaction mixture to a temperature sufficient to cause it to polymerize through an esterification mechanism until the reaction mixture reaches a desired acid value.

Abstract: Complexes of tropolone and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the complexes were stably retained in the wood providing a long lasting preservative.

Abstract: Cosmetics containing the following components (A) and (B): (A) an oil-absorbing powder having a squalane-absorbing ability of 1 ml/g or more; and (B) a compound having an affinity for component (A) lower than that of sebum, and having an ability to absorb the sebum and release component (B) in exchange for the sebum when the cosmetic is applied onto the skin. These cosmetics can adequately absorb the sebum and thus exhibit excellent effects of relieving or preventing oiliness of the skin and worsening in makeup. By selecting an appropriate compound to be released in exchange for the absorbed sebum, a substance capable of improving the skin qualities such as moistness, tightness, and tension can be allowed to penetrate into the skin. Moreover, a bodily feeling of the removal of the sebum can be imparted to users thereby.

Abstract: Textile treatment agents and/or capsules comprising a polymer having antiadhesive action against microorganisms which adhere to a textile substrate, methods of treating textile substrates therewith and the textile so treated, wherein the polymer comprises a polymeric structural element selected from the group consisting of polyesters, polysaccharides, polyethers, polyurethanes, polyureas, polyamides, and heteropolymers thereof.

Abstract: The present invention provides a method for the hydrophobic treatment of pigment particles comprising contacting said pigment particles with one or more silicone-based materials, that are substantially free of silicon-hydrogen bonds and fluorine, producing hydrophobic, non-covalently bound, modified pigment particles. Additionally, the present invention provides personal care compositions comprising said modified or coated pigment particles.

Abstract: The present invention is to provide a tissue-specific transporter inhibitor which is not absorbed through the digestive tract and can prevent deterioration in the QOL of a patient caused by diet therapy, and a therapeutic drug for tissue dysfunction diseases and a therapeutic drug for suppressing the progress of chronic renal failure containing the inhibitor as an active ingredient. A tissue-specific transporter inhibitor which is not absorbed through the digestive tract is constructed by introducing a dipeptide which is a ligand of an oligopeptide transporter 1 into a supramolecular structure polyrotaxane wherein its structurally modified active residue is expected to be excellent in the interaction with a transmembrane transporter.

Abstract: Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tg for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent.

Abstract: Compositions for oral and/or topical administration of a prebiotic and a physiologically active fatty acid, or a salt or ester thereof, are disclosed. The compositions are disclosed as enhancing the body's population of beneficial microorganisms for improving health and well-being.

Abstract: The present invention relates to a hydrophilic coating of a water-swellable hydrophilic matrix having incorporated therein an anti-microbial polymer, said anti-microbial polymer carrying pendant groups providing the anti-microbial effect, said pendant groups being selected from primary amino groups, secondary amino groups, tertiary amino groups, quaternary ammonium groups, imino groups, and phosphonium groups.

Abstract: Methods for treating glomerular basement membrane disease such as Alport syndrome involving matrix metalloproteinase-12 are disclosed. Treatment may be affected, for example, by administering matrix metalloproteinase-12 inhibitors, by administering CCR2 receptor inhibitors, or by administering MCP-1 inhibitors. Matrix metalloproteinase formation is affected by the CCR2 receptor, which is stimulated by the MCP-1 chemokine.

Abstract: Composition containing, in a physiologically acceptable medium, a tensioning polymer and organic-mineral hybrid particles. Process, particularly for facial skin, in particular wrinkled skin, involving the application of the invention composition to the skin.

Abstract: The present invention is directed to a method of making up keratinous substrates involving applying onto the keratinous substrate a composition containing a) a block copolymer, b) a tackifier, c) an alkyl silsesquioxane wax, d) a liquid fatty phase, and e) optionally, a colorant.

Abstract: The invention provides decorative cosmetic and dermatological compositions comprising at least one copolymer obtained by free-radical copolymerization of A) acryloyld imethyltaurine and/or acryloyld imethyltaurates, B) optionally, one or more further olefinically unsaturated, noncationic comonomers, C) optionally, one or more olefinically unsaturated, cationic comonomers, D) optionally, one or more silicon-containing components capable of free radical polymerization, E) optionally, one or more fluorine-containing components, F) optionally, one or more macromonomers, G) optionally, the copolymerization taking place in the presence of at least one polymeric additive, H) with the proviso that component A) is copolymerized with at least one component selected from one of the groups D) to G).

Abstract: The present application relates to a polycondensate that can be obtained by reaction: of polyol containing 3 to 6 hydroxyl groups; of non-aromatic, saturated or unsaturated mono-carboxylic acid; of aromatic monocarboxylic acid containing 7 to 11 carbon atoms; and of polycarboxylic acid, saturated or unsaturated, or even aromatic, linear, branched and/or cyclic, containing at least 2 carboxyl groups COOH; and/or a cyclic anhydride of such a polycarboxylic acid. The application also relates to a method of cosmetic treatment employing said composition, the polycondensate thus defined and a method of preparation of the polycondensate.

Abstract: The present invention relates to a composition for an immunopotentiator (adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.

Abstract: The present invention generally relates to pharmaceutical compositions for the treatment of various diseases and disorders, in particular the use of novel complexes of amine drugs with polyacrylic acid carbomer polymers. The compositions of the present invention can be administered transdermally or transmucosally to patients in need thereof for a systemic or for a local therapeutic effect. The compositions of the present invention present the additional benefits of being free or substantially free of excipients which may potentially be responsible for skin local reactions and unpleasant smell.

Abstract: The allergen inhibitor of this invention comprises at least one compound selected from the group consisting of an aromatic hydroxy compound, an alkali metal carbonate, alum, lauryl benzene sulfonate, lauryl sulfate, polyoxyethylene lauryl ether sulfate, and a divalent or more sulfate having either or both of a polyoxyethylene chain and a polyethylene chain in the molecule thereof.

Abstract: The invention relates generally to compatible polymer blends that can be extruded or injection molded into films or other objects that will generate and release a gas such as sulfur dioxide, carbon dioxide, or chlorine dioxide upon contact with moisture.

Abstract: According to this invention, allergenicity in an indoor space is reduced by denaturing allergens in allergen reservoirs that are capable of producing respiratory or skin reactions and physically removing the allergens from the allergen reservoirs in the indoor space. The allergen reservoirs may also be treated with pesticides and fungicides/fungistats to prevent reinfestation of house dust mites, molds and cockroaches.

Abstract: An additive mixture useful as a flame retardant is described. The mixture is comprised of (i) a poly(bromophenyl)alkane having in the molecule in the range of 13 to 60 carbon atoms and in the range of two to four aryl groups and (ii) a poly(bromophenyl)bromoalkane having in the molecule in the range of 13 to 60 carbon atoms and in the range of two to four aryl groups, said poly(bromophenyl)bromoalkane being in an amount which is greater than 25 wt %, based on the total weight of the additive mixture. A facile process for making the poly(bromophenyl)bromoalkane is also described.

Abstract: The invention provides a method for imparting antiviral properties to a hydrophilic polymeric material comprising preparing a hydrophilic polymeric slurry, dispersing an ionic copper powder mixture containing cuprous oxide and cupric oxide in said slurry and then extruding or molding said slurry to form a hydrophilic polymeric material, wherein water-insoluble particles that release both Cu++ and Cu+ are directly and completely encapsulated within said hydrophilic polymeric material.

Abstract: Film-forming compositions, as well as methods of making and using, wherein the compositions include an optional active agent, water, a surfactant, and a water-soluble or water-dispersible vinyl polymer comprising amine group-containing side-chains and a copolymerized hydrophobic monomer; wherein the amine equivalent weight of the polymer is at least about 300 grams polymer per equivalent of amine group.

Abstract: The present invention relates to a hydrophilic antimicrobial coating composition for an air conditioner evaporator of a vehicle with improved durability. In one embodiment of the present invention, the antimicrobial composition comprises a hydrophilic organic polymer with molecular weight in the range of about 4,000 to 8,000, a smoothing agent, an antimicrobial agent, and deionized water. In particular, the degree of polymerization between the hydrophilic functional group and a crosslinking group of the hydrophilic organic polymer is greatly improved. The antimicrobial composition is prepared with particles with a diameter of a few nanometers, which increases the number of particles per unit area and reduces the decomposition rate of the coated layer.

Abstract: The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.

Abstract: An adhesive composition is provided including one or more polymerizable cyanoacrylate monomers and boron trifluoride as a stabilizer or complexing agent. The adhesive composition may also include or be used with a decomplexing agent, particularly one or more quaternary ammonium fluoride salts or one or more quaternary ammonium ether salts. A polymerization initiator or accelerator may also be used. The viscosity of the adhesive composition may be controlled by addition of a thickening agent which may be a polymer or copolymer catalyzed by a boron trifluoride complex or compound. Methods for the application of the adhesive compositions to living tissue are also provided.

Abstract: The invention relates to a physiologically acceptable composition, in particular a cosmetic composition, containing at least one liquid fatty phase comprising at least one structuring polymer comprising a polymer skeleton having hydrocarbon-based repeating units containing at least one hetero atom, and and at least one gelling agent for the said fatty phase, the liquid fatty phase, the structuring polymer and the gelling agent forming a physiologically acceptable medium. This composition may be in the form of a stick of lipstick which is stable, which does not exude and whose application produces a glossy deposit with good staying power over time.

Abstract: This disclosure covers polymers, some of which are useful in medical device applications. Some of these medical devices are implantable within a mammalian body, such as in a body lumen. The copolymers comprise at least one alcoholic moiety derived from a diol, triol, or polyol. Additionally, the copolymers comprise an acidic moiety, derived from a polycarboxylic acid, and a biobeneficial moiety. Some of these copolymers are biodegradable or bioerodable. Medical devices comprising these polymers and methods of making these polymers are within the scope of this disclosure.

Abstract: The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.

Abstract: The subject invention provides a pharmaceutical composition comprising an aqueous carrier; from 0.1 mg/ml to 20 mg/ml of the composition of a pharmaceutically acceptable salt of a peptide having the structural formula NH2-Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Glu Glu Trp Ile Gly-COOH; and a substituted ?-cyclodextrin in an amount effective to dissolve the peptide in the aqueous carrier, wherein the composition has a pH between 4 and 9, a process for preparation, and a method of alleviating symptoms of systemic lupus erythematosus (SLE) in a human subject comprising administering to the human subject the pharmaceutical composition.

Abstract: A wound healing powder, comprising a sugar selected from the group consisting of one or more pharmaceutically acceptable monosaccharides and disaccharides, in an amount of at least 25% by weight of the powder mixture; and an absorbent agent which forms a bioabsorbable biocompatible matrix with wound secretions, comprising a polymer formed of one or more of saccharide or saccharide derivative monomers and lactic acid monomers, in an amount of at least 25% by weight of the powder mixture.

Abstract: The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions that are accompanied by an NADPH oxidase deficiency, and methods and materials involved in identifying agonists and antagonists of NADPH oxidase activity.

Abstract: This invention relates to a nonleachable waterborne wood preservative composition that combines one or more resin acids, mostly or fully in the carboxylate anion form, with one or more organic biocides to enhance the efficacy of relatively high-cost organic biocides. Resin acids are cost effective and environmentally safe, and therefore can be used as a low-cost and environmentally-benign additive to help protect wood against wood-destroying fungi. Furthermore, wood treated with a waterborne resin acid formulation will have enhanced water repellency, which will result in better dimensional stability for wood exposed to water. This invention also provides a method for the use of the described composition.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: Compositions for combating ectoparasites, and particularly head lice and their nits comprise a low viscosity linear polysiloxane combined with a higher viscosity linear polysiloxane and at least one spreading agent. The low viscosity linear polysiloxane has a viscosity of less than 10 cSt and is present in a weight percentage of 30-40% of the formulation, while the higher viscosity linear polysiloxane has a viscosity of greater than 90 cSt and is present in a weight percentage of 35-65%.