Solid Synthetic Organic Polymer As Designated Organic Active Ingredient (doai) Patents (Class 424/78.08)
  • Patent number: 8282912
    Abstract: Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: October 9, 2012
    Assignee: Kuros Biosurgery, AG
    Inventors: Aaldert Rens Molenberg, Enrico Zamparo, Laurent Rapillard, Simona Cerritelli
  • Patent number: 8282911
    Abstract: The present relates to the field of dental and bone surgery. In particular, the invention relates to fibrous pharmaceutical compositions; fibrous webs, yarns and woven fabrics of such pharmaceutical compositions; to implant material essentially consisting of fibrous pharmaceutical compositions; to the manufacturing and use of such fibers/webs/implant materials.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: October 9, 2012
    Assignees: ETH Zürich, Universitat Zürich
    Inventors: Jan W. Stark, Oliver Schneider, Stefan Loher, Tobias Brunner, Marc Simonet, Patrick Schmidlin, Robert N. Grass
  • Patent number: 8268300
    Abstract: It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: September 18, 2012
    Assignees: RIKEN, The Chemo-Sero-Therapeutic Research Institute
    Inventors: Hiroshi Ujiie, Yoshiaki Suzuki, Masaya Iwaki, Takanori Uchida
  • Publication number: 20120231043
    Abstract: There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
    Type: Application
    Filed: March 9, 2012
    Publication date: September 13, 2012
    Inventors: Karin Leontein, Per Antoni, Daniel Nyström, Paul Begovac, Krzysztof Pietrzak
  • Patent number: 8263666
    Abstract: Composition for topical application in the form of an oil-in-water emulsion containing an oily phase dispersed in an aqueous phase, and a hydrophilic polymer, the composition further containing (1) at least one elastomeric organopolysiloxane and (2) at least one lipophilic compound chosen from lipophilic amino acid compounds and lipophilic salicylic acid compounds. Uses thereof, including topical application to the skin, lips, hair, etc. Stabilization of certain emulsions using a lipophilic compound.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: September 11, 2012
    Assignee: L'Oreal
    Inventors: Christine Noel, Anne-France Livernette
  • Patent number: 8263060
    Abstract: The invention provides polyanhydrides that degrade in less than 60 hours following topical administration to deliver biologically active compounds.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: September 11, 2012
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Kathryn E. Uhrich, Young Mi Kim
  • Patent number: 8263061
    Abstract: The present invention is directed to a series of alkyl quaternium silicone compounds having both alkyl groups and fatty quaternary nitrogen groups attached in one molecule, and the intermediates formed during the production thereof, that are suitable for use in personal care and other applications. These compounds by virtue of their unique structure provide outstanding micro-emulsions and provide outstanding hair conditioning.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: September 11, 2012
    Assignees: Colgate-Palmolive Company, Siltech Corporation
    Inventors: Anthony J. O'Lenick, Jr., Zhi Lu, Marian N. Holerca, Mark Riddle, Gregory Szewczyk, Rick Vrckovnik
  • Patent number: 8257735
    Abstract: The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free recombinant human insulin isophane and free Recombinant human regular insulin insulin and a mixture of recombinant human insulin isophane and Recombinant human regular insulin insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Recombinant human insulin isophane and Recombinant human regular insulin insulin are present within the complex in at least one form wherein the recombinant human insulin isophane and Recombinant human regular insulin insulin have regions of positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: September 4, 2012
    Assignee: SDG, Inc
    Inventors: John R. Lau, W. Blair Geho
  • Patent number: 8258259
    Abstract: The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: September 4, 2012
    Assignee: Starpharma Pty Limited
    Inventors: Guy Yeoman Krippner, Gottfried Lichti, Pasquale Razzino, Brian Devlin Kelly, Susanne Pallich, Scott Andrew Henderson, Angela Michelle Scheppokat, Charlotte Claire Williams, Christopher John Hamilton Porter, Benjamin James Boyd, Lisa Michelle Kaminskas, Phillip Martin Rendle, Ben William Greatrex
  • Patent number: 8257690
    Abstract: Tissue adhesives formed by crosslinking albumin and/or gelatin with certain polyamines and/or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: September 4, 2012
    Assignee: Actamax Surgical Materials, LLC
    Inventor: Henry Keith Chenault
  • Patent number: 8252335
    Abstract: A wound healing powder, comprising a sugar selected from the group consisting of one or more pharmaceutically acceptable monosaccharides and disaccharides, in an amount of at least 25% by weight of the powder mixture; and an absorbent agent which forms a bioabsorbable biocompatible matrix with wound secretions, comprising a polymer formed of one or more of saccharide or saccharide derivative monomers and lactic acid monomers, in an amount of at least 25% by weight of the powder mixture.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: August 28, 2012
    Inventor: Philip A. Maraccini
  • Patent number: 8221796
    Abstract: The present invention discloses an improved copper-based fungicide/bactericide composition. The improved composition offers higher biological activity over typical copper-based products, while requiring significantly less copper in the composition. The present invention also discloses methods of making the improved copper-based fungicide/bactericide composition. The present invention further discloses methods of using the improved copper-based fungicide/bactericide composition.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: July 17, 2012
    Assignee: Albaugh, Inc.
    Inventors: Alfonso Gutierrez Martinez, Laura Elizabeth Bailon Cisneros, Pablo Diaz Toledo, Raul Salazar Franco
  • Patent number: 8216560
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 10, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, John Fordtran, Gerrit Klaerner, Jerry M. Buysse, Robert Alpern, Mingjun Liu
  • Patent number: 8211418
    Abstract: Tissue adhesives formed by crosslinking albumin and/or gelatin with certain polyamines and/or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 3, 2012
    Assignee: Actamax Surgerical Materials, LLC
    Inventor: Henry Keith Chenault
  • Publication number: 20120164206
    Abstract: A tissue product comprising an additive composition onto at least the surface of a fibrous article in order to increase the surface potential of the article, while retaining or improving manufacturing efficiency is disclosed. The additive composition comprises a bacteriostatic component and more preferably a water-soluble adhesive component and a bacteriostatic component. In some aspects, the additive may also contain additional water-soluble modifier components. Tissue products according to the present disclosure can attract and trap negatively charged matter, such as bacteria, into the tissue web. As such, tissue products can pickup bacteria from a surface and substantially hold the bacteria in the sheet to help prevent spreading bacteria to other surfaces.
    Type: Application
    Filed: December 28, 2010
    Publication date: June 28, 2012
    Inventors: Dave Allen Soerens, Cathleen Mae Uttecht, Bao Trong Do, SooYeon Oh
  • Patent number: 8197828
    Abstract: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: June 12, 2012
    Assignee: Nitto Denko Corporation
    Inventors: Sang Van, Yucheng Song, Xinghe Wang, Zheng Hou, Zhongling Feng, Gang Zhao, Lei Yu
  • Patent number: 8192766
    Abstract: The present invention discloses an improved copper-based fungicide/bactericide composition. The improved composition offers higher biological activity over typical copper-based products, while requiring significantly less copper in the composition. The present invention also discloses methods of making the improved copper-based fungicide/bactericide composition. The present invention further discloses methods of using the improved copper-based fungicide/bactericide composition.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: June 5, 2012
    Assignee: Albaugh, Inc.
    Inventors: Alfonso Gutierrez Martinez, Laura Elizabeth Bailon Cisneros, Pablo Diaz Toledo, Raul Salazar Franco
  • Patent number: 8192838
    Abstract: The invention relates to polymers whose water solubility may be triggered by changes in pH, salt concentration, concentration of surfactant or a combination of both. The polymer is a copolymer or terpolymer containing from 2 to 60 mole percent of an amine functionality that has been neutralized with a fixed acid. Specifically films formed from these polymers will be insoluble at a higher pH, but will become soluble at a lower pH. The polymers are also insoluble at a higher salt concentration, but become soluble at a lower salt concentration. The polymers can be used to coat or encapsulate active ingredients, that are released based on changes in the environment, such as in the rinse cycle of a dishwasher or laundry washing machine.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: June 5, 2012
    Assignee: Akzo Nobel N.V.
    Inventors: Susanne H. Goodson, Klein A. Rodrigues
  • Patent number: 8187631
    Abstract: The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: May 29, 2012
    Assignee: Genzyme Corporation
    Inventors: Joseph Tyler, John S. Petersen
  • Publication number: 20120121704
    Abstract: The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
    Type: Application
    Filed: July 14, 2011
    Publication date: May 17, 2012
    Applicant: Genzyme Corporation
    Inventors: Hitesh R. Bhagat, Jeffrey M. Goldberg, Abizer I. Harianawala, Louis Brenner
  • Publication number: 20120121687
    Abstract: The present invention provides a wound healing material and method for fabricating the same. The wound healing material comprises a hydrophobic fluoro-containing membrane having a first surface and a second surface opposing to each other; and at least one biocompatible polymer covalently bonded to at least one part of the first surface of the membrane wherein the membrane is air permeable but liquid impermeable and the water contact angle of the first surface formed with the biocompatible polymer is smaller than or equal to 40 degrees.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 17, 2012
    Applicant: CHUNG YUAN CHRISTIAN UNIVERSITY
    Inventors: Yung Chang, Hung-Hsing Hsu, Kuo-Lun Tung, Jheng-Fong Jhong, Ta-Chin Wei
  • Patent number: 8173765
    Abstract: A polymer having a number average molecular weight (Mn) of about 10 000 g/mol comprising a monomeric rigid moiety R and a monomeric flexible moiety F, wherein R comprises a main-chain polycyclic core and F has a main chain comprising a number of atoms sufficient for the transition temperature of the polymer to be lower than the degradation temperature of the polymer is provided. A method of manufacturing of same is also provided. Biomedical devices, scaffolds and supports for tissue engineering, delivery devices, textiles, moulds, vehicle parts, tubes, active disassembly devices, microactuators, toys and inflatable membranes comprising same are also described.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: May 8, 2012
    Assignee: Valorisation-Recherche, Limited Partnership
    Inventors: Xiao-Xia Zhu, Julien Gautrot, Jie Zhang, Yu Shao
  • Patent number: 8173113
    Abstract: A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: May 8, 2012
    Assignee: 3M Innovative Properties Company
    Inventors: Matthew T. Scholz, Robert A. Scherrer, Nelda M. Marecki, Yen-Lane Chen, Joan K. Barkhaus
  • Publication number: 20120107381
    Abstract: The present invention is directed to powder formulations of a potassium-binding active agent, a suspending agent, and a glidant; optionally, other excipients can be added to the formulations. These formulations can be in a powder form and are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: May 13, 2010
    Publication date: May 3, 2012
    Applicant: RELYPSA, INC.
    Inventors: Dasharatha Reddy, George Tyson
  • Patent number: 8158106
    Abstract: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: April 17, 2012
    Assignee: Surmodics, Inc.
    Inventors: Patrick E. Guire, Kristin S. Taton, John V. Wall
  • Patent number: 8158575
    Abstract: Use of a polylysine, polyamidoamine or polypropylenimine dendrimer having naphthyl disulphonate terminal groups as a topically applied agent in prophylaxis or treatment of sexually transmitted diseases.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: April 17, 2012
    Assignee: Starpharma Pty., Ltd
    Inventors: Barry Ross Matthews, George Holan, Peter Karellas, Scott Andrew Henderson, David Francis O'Keefe
  • Publication number: 20120087963
    Abstract: Disclosed is a method for killing spores from a surface or a material, comprising applying an effective amount of a biocidal composition which comprises one or more biguanide polymers, and one or more further active agents on said surface or material, characterised in that the or each further active agent is, when taken alone, sporicidally inactive. Compositions comprising polymeric biguanides and one or more further biocidal agents and, optionally, a polyorganosiloxane, have been found to be effective as a sporicidal agent and are particularly effective against the spores of C. difficile. The compositions may be used in industry, in domestic applications and are particularly suitable for use in hospital due to their low toxicity. Furthermore, the method may comprise impregnating a fabric to thereby provide long lasting sporicidal activity thereto.
    Type: Application
    Filed: March 1, 2010
    Publication date: April 12, 2012
    Applicant: BIO TECHNICS LIMITED
    Inventors: Thomas David Evans, David Gordon Hill
  • Patent number: 8143325
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 27, 2012
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20120065641
    Abstract: A bone repair apparatus includes a partially polymerized biocompatible adhesive provided in a state wherein polymerization of the biocompatible adhesive is substantially suspended. A method for repairing a bone defect includes preparing the biocompatible adhesive, suspending polymerization of the biocompatible adhesive prior to full cure, delivering the biocompatible adhesive to the bone defect while polymerization is substantially suspended and accelerating polymerization of the biocompatible adhesive to achieve full cure. The method provides an implanted biocompatible adhesive with a malleable osteoconductive structure without compromising the physical characteristics of the biocompatible adhesive, thereby improving handling and delivery of the bone adhesive.
    Type: Application
    Filed: September 14, 2010
    Publication date: March 15, 2012
    Applicant: Doctors Research Group, Inc.
    Inventors: Richard J. Deslauriers, Eric Kolb, John A. Tomich, John Boxberger, Naresh Akkarapaka
  • Patent number: 8133959
    Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: March 13, 2012
    Assignee: REVA Medical, Inc.
    Inventors: Donald K Brandom, Joan Zeltinger, Eric V Schmid, Joseph J Mallon
  • Patent number: 8114386
    Abstract: Stable, single phase, low VOC, topical insect repellent compositions containing a film-forming polymer, insect repellent, water miscible organic solvent, and water.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: February 14, 2012
    Assignee: 3M Innovative Properties Company
    Inventor: Steven S. Kantner
  • Publication number: 20120027698
    Abstract: Disclosed herein is a cosmetic and/or pharmaceutical composition comprising, in a physiologically acceptable medium, at least one (co)polymer comprising a polymer backbone and at least one junction group linked to the polymer backbone and capable of establishing H bonds with at least one partner junction group, each pairing of a junction group involving at least 3H bonds, wherein the at least one (co)polymer comprises at least one ionizable group. Also disclosed herein is a cosmetic treatment process comprising applying the composition to keratin materials.
    Type: Application
    Filed: July 9, 2010
    Publication date: February 2, 2012
    Inventors: Nathalie Mougin, Sandrine Chodorowski-kimmes, Xavier Schultze
  • Patent number: 8105652
    Abstract: A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: January 31, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Kris C. Wood, Helen F. Chuang, Robert D. Batten, David M. Lynn, Paula T. Hammond Cunningham
  • Patent number: 8105617
    Abstract: A cosmetic composition is provided which includes a silicone elastomer, a cationic copolymer with monomeric units selected from at least an acryloylethyl tri(C1-C3 alkyl)ammonium salt, and light reflecting platelet shaped particles. The compositions are particularly useful to impart radiance as well as soft focus effects onto the skin. A particular useful cationic copolymer is that of acrylamide/acryloylethyl trimethylammonium chloride/tris(hydroxymethyl)acrylamidomethane copolymer.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 31, 2012
    Assignee: Conopco, Inc.
    Inventors: Jack Polonka, John Brian Bartolone
  • Patent number: 8092837
    Abstract: The present invention provides a non-liquid biomaterial that may be used as a surgical sealant, a suture support, a blood flow controller, an adhesion reducing agent, an adhesion preventing agent, a tissue support, a tissue filler, a wound dressing or a combination thereof. The non-liquid biomaterial may comprise a blood derived material such as plasma, platelet poor plasma, platelet rich plasma or a material derived from blood containing tissue aspirate, such as bone marrow aspirate, a protein binding agent and a polymerizing agent. Methods for making and using the non-liquid biomaterial are also provided.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: January 10, 2012
    Assignee: Biomet Manufacturing Corp
    Inventors: Hillary Enyart, Jacy Hoeppner, Mike Leach, Shon Steger, Sona Sundaramurthy
  • Publication number: 20120003175
    Abstract: The invention relates to pharmaceutical compositions and formulations comprising polymeric myrcene. More particularly, the invention relates to compositions comprising an isolated fraction of polymeric myrcene in a hydrophobic carrier and formulations which maintain the biological activity of the active polymer.
    Type: Application
    Filed: March 4, 2010
    Publication date: January 5, 2012
    Inventor: Zadik Hazan
  • Patent number: 8088365
    Abstract: PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation period for a drug-PEG conjugate, followed by hydrolytic breakdown of the conjugate and release of the bound molecule. In some cases, drugs that demonstrate reduced activity when permanently coupled to PEG maintain a therapeutically suitable activity when coupled to a degradable PEG in accordance with the invention. The PEG derivatives of the invention can be used to impart improved water solubility, increased size, a slower rate of kidney clearance, and reduced immunogenicity to a conjugate formed by attachment thereto. Controlled hydrolytic release of the bound molecule into an aqueous environment can then enhance the drug's delivery profile by providing a delivery system which employs such polymers and utilizes the teachings provided herein.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: January 3, 2012
    Assignee: Nektar Therapeutics
    Inventor: J. Milton Harris
  • Patent number: 8084435
    Abstract: A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: December 27, 2011
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Robert J. Levy, Ilia Fishbein
  • Patent number: 8076450
    Abstract: A system, including methods and compositions, for treatment of ischemia.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: December 13, 2011
    Assignee: Morehouse School of Medicine
    Inventors: Roger P. Simon, Zhi-Gang Xiong
  • Publication number: 20110300202
    Abstract: Polymeric articles capable of releasing drugs at therapeutic levels over extended periods of time, and methods for producing the extended release articles.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 8, 2011
    Inventors: Mohamed E. Labib, Theodore Davidson, Stanislav S. Dukhin, James Christopher Post, Garth Ehrlich, Paul Stoodley
  • Patent number: 8073538
    Abstract: To control cardiac arrhythmias such as atrial fibrillation post-operatively, various non-ablative agents include polymers, fibroblasts, neurotoxins, and growth factors are introduced into one or more cardiac fat pads into the atrioventricular nodal fat pad in proximity to the autonomic ganglia therein. Any desired technique may be used for introducing the agent, including injection. The sinoatrial nodal fat pad target site and the atrioventricular nodal fat pad target site are identified using a stimulator, which may have electrodes coupled thereto or which may coupled to electrodes built into a delivery system.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: December 6, 2011
    Assignee: Cardio Polymers, Inc.
    Inventors: Nicholas S. Peters, Mark Maciejewski, Todor N. Mazgalev
  • Patent number: 8071692
    Abstract: The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: December 6, 2011
    Assignee: Nektar Therapeutics
    Inventor: Xuan Zhao
  • Publication number: 20110295190
    Abstract: Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-soluble film-forming polymeric carrier material and a water-soluble glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Additional active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-soluble glass.
    Type: Application
    Filed: August 10, 2011
    Publication date: December 1, 2011
    Applicant: TYCO HEALTHCARE GROUP LP
    Inventors: Nicole David, David Fink, Alain Tranchemontagne
  • Patent number: 8067398
    Abstract: Optically active polymers that are composed of monomer residues derived from chiral pre-polymerized monomers, which maintain the chirality of the pre-polymerized monomers upon polymerization are disclosed. These polymers can be composed of monomer residues that are derived from readily available chiral monomers and can be designed to have pre-determined characteristics such as chirality, biodegradability and functionality. Uses of these polymers as therapeutically active agents, and/or as carriers of therapeutically active agents, for delivering the active agents to a targeted bodily site and/or for a sustained release of the active agent, are further disclosed. Also disclosed are processed of preparing the polymers, compositions and medical devices containing the polymers, and conjugates of these polymers and various agents.
    Type: Grant
    Filed: June 4, 2006
    Date of Patent: November 29, 2011
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yehoshua Katzhendler, Abraham Jackob Domb
  • Patent number: 8062653
    Abstract: The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain susceptible to hydrolytic degradation and wherein the macromer or oligomer comprises of repeat units derived from safe and biocompatible molecules such as glycolic acid, lactic acid, caprolactone and p-dioxanone. Furthermore, the present invention relates to controlled release of nitric oxide (NO) and/or drug molecule from a NO and drug releasing macromer or oligomer. Moreover, the present invention also relates to medical devices, medical device coatings and therapeutic formulations comprising of nitric oxide and drug releasing macromers and oligomers of the present invention.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: November 22, 2011
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Patent number: 8056733
    Abstract: Structures treated with a microbiological interception enhancing agent comprising of a water-soluble cationic material having a counter ion associated therewith at specific sites on the cationic material, in combination with a biologically active metal salt, wherein the counter ion associated with the cationic material preferentially precipitates with at least a portion of the cation of the biologically active metal salt such that precipitation of the biologically active metal cation and the counter ion associated with the cationic material occurs in proximity to the cationic material are disclosed herein. The microbiological interception enhancing agent may be incorporated into articles of commerce by treating the starting materials of the structure or by applying the microbiological interception enhancing agent on to at least one surface of the article.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: November 15, 2011
    Assignee: KX Technologies LLC
    Inventor: Evan E Koslow
  • Patent number: 8048659
    Abstract: A tagged water-soluble polymer linked to a solid support is provided and includes a solid support optionally including a spacer sequence including one or more spacer monomer units attached to the solid support; and a water-soluble polymer covalently linked to the solid support or to the spacer sequence, the water-soluble polymer including a first cleavage segment including at least one monomer unit including a selectively cleavable link to the solid support or to the spacer sequence, where cleavage of the selectively cleavable link separates the water-soluble polymer from the solid support, a second segment including at least one monomer unit selected from a monomer unit linked to a reactive functionality able to be covalently coupled to a tag or linked to a tag, a third segment including one or more monomer units linked to a reactive functionality that can form a covalent bond with an analyte-binding species or an analyte, and optionally one or more spacer monomer units provided adjacent to any segment and/o
    Type: Grant
    Filed: October 7, 2000
    Date of Patent: November 1, 2011
    Inventors: Robert C. Leif, Lidia Vallarino
  • Patent number: 8048407
    Abstract: A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 1, 2011
    Inventors: Brent Vernon, Merrill Birdno, Mark C. Preul
  • Patent number: 8029774
    Abstract: A composition includes at least one biologically active agent covalently attached to a first polymerizing molecule that is adapted to undergo a free radical polymerization. The first polymerizing molecule retains the ability to undergo free radical polymerization after attachment of the bioactive agent thereto. The first polymerizing molecule is preferably biocompatible. The polymerizing molecule can, for example. be dihydroxyphenyl-L-alanine (DOPA) or tyrosine. The composition can also include a second component synthesized by reacting at least one core molecule having a plurality of reactive hydrogen groups with at least one multi-isocyanate functional molecule to create a conjugate including terminal isocyanate groups. The conjugate molecule is reacted with a second polymerizing molecule that is adapted to undergo a free radical polymerization. The second polymerizing molecule includes a reactive hydrogen to react with the isocyanate groups of the conjugate.
    Type: Grant
    Filed: July 1, 2006
    Date of Patent: October 4, 2011
    Assignee: University of Pittsburgh
    Inventors: Eric J. Beckman, Stephen F. Badylak, Alan H. Wells, Jianying Zhang, Donald Freytes
  • Patent number: 8030442
    Abstract: Methods and compositions that inhibit acid sensing ion channels are provided for the prevention and treatment of brain injury, including injury caused by stroke or seizure. The methods and compositions of the invention are additionally effective for the reduction of acidosis in the brain.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: October 4, 2011
    Assignee: Morehouse School of Medicine
    Inventors: Roger P. Simon, Zhi-Gang Xiong