Medical Or Dental Purpose Product; Parts; Subcombinations; Intermediates (e.g., Balloon Catheter, Splint) Patents (Class 427/2.1)
  • Patent number: 8124166
    Abstract: The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: February 28, 2012
    Assignee: Medtronic Vascular, Inc.
    Inventors: Gary Owens, Brian Wamhoff, Matthew S. Hudson, Whye-Kei Lye, Joshua Spradlin, Michael Reed, Kareen Looi
  • Patent number: 8124165
    Abstract: The present disclosure provides a method and apparatus for coating a medical device.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: February 28, 2012
    Assignee: Tyco Healthcare Group LP
    Inventor: Steve Tsai
  • Patent number: 8122849
    Abstract: An apparatus and method are provided for producing pharmaceutical and pharmaceutical-like products. The apparatus and method provide real-time monitoring of the pharmaceutical product and can provide real-time control. The apparatus and method can monitor the dosage both before and after it has been added to a carrier substrate. The apparatus and method can provide monitoring of each pharmaceutical product that is processed.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: February 28, 2012
    Assignee: SmithKline Beecham Corporation
    Inventors: Allan J. Clarke, David George Doughty, Frederick H Fiesser, David Tainsh, Dwight Walker, David Wagner
  • Patent number: 8124167
    Abstract: A medical device such as a wire guide has a lubricious and/or therapeutic coating adhered to an etched, carbonaceous polymeric surface, for example a sodium-etched polymer surface. A method for preparing a lubricious and/or therapeutic coating on a medical device includes etching a polymeric portion of the device to create a carbonaceous surface and applying a lubricious and/or therapeutic coating on the etched surface.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: February 28, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Tamisha Clark, Barry H. Chilton
  • Patent number: 8119184
    Abstract: A stent of variable surface area as determined by stent struts. The stent can have a variable surface area per unit length which accommodates a therapeutic agent. A patterned distribution of therapeutic agent can be provided throughout the stent. The stent can have an increased level of therapeutic agent near an end of the stent. A decreased level of therapeutic agent can be provided near an end of one embodiment of a stent. Indentations can be provided at the surface of the stent with therapeutic agent disposed therein. The stent can be cut with struts of variable thickness to provide the variable stent surface area.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: February 21, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed Hossainy, Fuh-Wei Tang, Brian P. Cahill
  • Patent number: 8119183
    Abstract: Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet to the metal surface to impregnate the surface of the article with the dopant. The method also comprises delivering substantially simultaneously a first set of particles comprising a dopant and a second set of particles comprising an abrasive from at least one fluid jet to a surface of an article to impregnate the surface of the article with the dopant.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: February 21, 2012
    Assignee: EnBIO Limited
    Inventors: John Gerard O'Donoghue, Donncha Haverty
  • Publication number: 20120041546
    Abstract: Implantable biocompatible polymeric medical devices include a substrate with a plasma-modified surface which is subsequently modified to include click reactive members.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 16, 2012
    Inventors: Nadya Belcheva, Ferass Abuzaina, Amin Elachchabi, Mbiya Kapiamba, Ahmed Robert Hadba
  • Patent number: 8114464
    Abstract: The present disclosure provides various novel methods for forming hybrid thin films that contain multi-lamellar assemblies of phospholipid bilayers and can incorporate proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such bilayer lipid membranes including, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: February 14, 2012
    Assignee: STC.UNM
    Inventors: Gabriel Lopez, Plamen Atanasov, Gautam Gupta
  • Patent number: 8110243
    Abstract: A coating for a stent and methods for coating a stent are provided. The coating may be used for the sustained delivery of an active ingredient or a combination of active ingredients.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: February 7, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Syed Faiyaz Ahmed Hossainy
  • Patent number: 8110242
    Abstract: The present invention provides hydrogel coated, implantable medical devices and methods of coating hydrogels onto implantable medical devices. In one embodiment, a hydrogel coated medical device is formed by physically treating a surface of the medical device, chemically treating the surface, applying a hydrogel precursor and then crosslinking the hydrogel precursor to form a hydrogel coating on the surface of the medical device. The present invention may be particularly applicable for coating articulating surfaces on implantable medical devices such as artificial joints.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: February 7, 2012
    Assignee: Zimmer, Inc.
    Inventors: Michael E. Hawkins, Dirk L. Pletcher, Brian Thomas, Kai Zhang, Hallie E. Brinkerhuff
  • Publication number: 20120024743
    Abstract: The present invention relates to semisolid transdermal pharmaceutical preparation having enhanced stability and bioavailability, wherein the particles are coated by a volatile silicon oil component and the thus obtained suspension is dispersed in a gel or cream base.
    Type: Application
    Filed: February 5, 2010
    Publication date: February 2, 2012
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulasik, Patrik Fazekas
  • Publication number: 20120029654
    Abstract: Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.
    Type: Application
    Filed: February 8, 2010
    Publication date: February 2, 2012
    Inventors: Tao Xu, Yuyu Yuan
  • Patent number: 8104469
    Abstract: A medicinal inhalation device having applied to surface thereof a composition comprising a monofunctional polyfluoropolyether silane and a non-fluorinated cross-linking agent.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: January 31, 2012
    Assignee: 3M Innovative Properties Company
    Inventor: Rudolf J. Dams
  • Patent number: 8105652
    Abstract: A decomposable thin film comprising a plurality of polyelectrolyte layers of alternating charge, wherein decomposition of the thin film is characterized by degradation of at least a portion of the polyelectrolyte layers.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: January 31, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Kris C. Wood, Helen F. Chuang, Robert D. Batten, David M. Lynn, Paula T. Hammond Cunningham
  • Patent number: 8101275
    Abstract: The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: January 24, 2012
    Assignee: Celonova Biosciences, Inc.
    Inventors: Andreas Schüssler, Michael Grunze, Roman Denk
  • Patent number: 8097291
    Abstract: The present invention is directed to methods, processes, and systems for coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under these methods and processes of the invention, a means to repel may be positioned on a mandrel prior to applying a coating to the workpiece. The means to repel may prevent the coating of a target surface of the workpiece.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: January 17, 2012
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Gerald Fredrickson, Lan Pham, Marlene Schwarz, Todd Robida
  • Patent number: 8092854
    Abstract: A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non-leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: January 10, 2012
    Assignee: Quick-Med Technologies, Inc.
    Inventors: William Toreki, Bernd Liesenfeld, David Moore, Susan Leander, Christopher Batich
  • Patent number: 8093307
    Abstract: The invention relates to novel silane compounds corresponding to the following formula (I): in which R1 can represent a methyl group, R2 and R3 can represent a hydrogen atom, A can represent —O—, E can represent an alkylene group, X can represent a methoxysilane group, Z can represent a simple bond and Y can represent an —N2 or —N—NH2 group. Use of these silane compounds to functionalize solid supports and to immobilize biological molecules on these supports.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: January 10, 2012
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Franck Martin, Antoine Hoang
  • Patent number: 8092855
    Abstract: Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: January 10, 2012
    Assignee: California Institute of Technology
    Inventors: Andrea M. Armani, Akinleye C. Alabi, Mark E. Davis, Richard C. Flagan, Scott E. Fraser
  • Publication number: 20110316696
    Abstract: A medical device (101), such as a blood pressure cuff or other device, includes an unauthorized reprocessing warning (406) printed in a first printable media (103). The first printable media (103) is configured to change from a first state to a second state upon exposure to an applied stimulus (203). A mask (407) is printed on or about the unauthorized reprocessing warning (406) in a second printable media (106). The second printable media (106) is configured to also change state upon exposure to an applied stimulus (203). The unauthorized reprocessing warning (406) is legible only after exposure to the applied stimulus (203). However, application of a reversion stimulus 306 will render the unauthorized reprocessing warning (406) non-legible.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 29, 2011
    Inventors: Min Yao, Kan P. Lu
  • Patent number: 8084076
    Abstract: A process for depositing an active substance on selected regions of the surface of a stent, comprising: (i) providing the active substance in at least one form selected from the group consisting of a powder and a paste; and (ii) depositing the active substance on the selected regions of the surface of the stent. Preferably, the active substance comprises or consists essentially of FK506, such as FK506 in the form of a powder with a grain size smaller than 15 micron or a paste with a base of FK506 with a viscosity not lower than 100,000 to 120,000 cps.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: December 27, 2011
    Assignee: Sorin Biomedica Cardio S.R.L.
    Inventors: Andrea Grignani, Maria Curcio, Vincenzo Cassolaro
  • Publication number: 20110311455
    Abstract: A nano-capsule construct for imaging and therapeutic uses and method for production are provided. One nano-probe embodiment based on genome-depleted plant brome mosaic virus (BMV) whose interior is doped with indocyanine green (ICG), an FDA-approved near infrared fluorescent dye, is used to illustrate the invention. The material encapsulated in viral shell components may be coated with functionalized coatings such as branched, dendritic polymer coatings to improve longevity and distribution in the body as well as antibody conjugation for increased target specificity. The constructs can also be coated with ferromagnetic iron oxide nanoparticles, enabling the ICG-containing capsules to be used as nano-probes with the capability of being detected in both optical and magnetic resonance imaging. The capsules may be produced by purifying a plant or animal viruses and disassembling the viruses to provide virus shell components.
    Type: Application
    Filed: June 8, 2011
    Publication date: December 22, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Bahman Anvari
  • Publication number: 20110311605
    Abstract: Provided herein are coating designs for the tailored release of two therapeutic agents from polymer coatings and methods of making and using the same.
    Type: Application
    Filed: June 27, 2011
    Publication date: December 22, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Publication number: 20110311713
    Abstract: A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member.
    Type: Application
    Filed: June 17, 2010
    Publication date: December 22, 2011
    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC.
    Inventors: David O'Neill, Matthew Coates
  • Patent number: 8079832
    Abstract: The invention relates to a device for the actively-controlled deposition of microdrops of biological solutions. The inventive device consists of at least one flat silicon lever comprising a central body and an end area which forms a point, a slit or groove being disposed in said point. The invention is characterized in that it also comprises at least one metallic track which is disposed on one face of the central body and which runs alongside said slit or groove at least partially. The invention also relates to a method of producing the inventive device and a method for the active-controlled deposition and sampling of microdrops of biological solutions using said device.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: December 20, 2011
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Christian Bergaud, Matthieu Guirardel, Pascal Belaubre, Benoît Belier, Jean-Bernard Pourciel
  • Patent number: 8075823
    Abstract: The present invention relates to processes for preparing an antimicrobial plastic body, said processes comprising molding a precursor and being characterized in that prior to molding at least one component of the precursor is treated with a metal colloid.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: December 13, 2011
    Inventors: J. Peter Guggenbichler, Andreas Hirsch
  • Patent number: 8075940
    Abstract: A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.
    Type: Grant
    Filed: January 19, 2009
    Date of Patent: December 13, 2011
    Assignees: Sungkyunkwan University Foundation for Corporate Collaboration, Samsung Life Welfare Foundation
    Inventors: Dae-Joong Kim, In-Su Baek, Jong-Sang Park, Hye-Yeong Nam, Chengzhe Bai
  • Patent number: 8071155
    Abstract: Medical devices, such as stents, and methods of making the devices are disclosed. In some embodiments, a method includes diffusing a first element into a first portion of the medical device. The first element includes carbon, hydrogen, nitrogen, oxygen, or combinations thereof. The first portion includes a refractory material.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: December 6, 2011
    Assignee: Boston Scientific SciMed, Inc.
    Inventor: Torsten Scheuermann
  • Patent number: 8069814
    Abstract: Various embodiments of methods and devices for coating stents are described herein.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: December 6, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Ryan E. Guerriero, Yung-Ming Chen, Celenia Gutierrez, Ian J. Coulson, Nathan Harold, Andrew Tochterman
  • Patent number: 8071168
    Abstract: A new, low temperature method for directly writing conductive metal traces with micron and sub-micron sized features. In this method, a flat beam is used, such as an AFM cantilever, with or without a tip, to draw traces of metal precursor ink onto a substrate. The dimensions of the metal traces can be directly controlled by the geometry of the cantilever, so that one can controllably deposit traces from 1 micron to over 100 microns wide with microfabricated cantilevers. Cantilevers with sharp tips can be used to further shrink the minimum features sizes to sub-micron scale. The height of the features can be increased by building layers of similar or different material.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: December 6, 2011
    Assignee: Nanoink, Inc.
    Inventors: Sylvain Cruchon-Dupeyrat, Hua Zhang, Robert Elghanian, Linette Demers, Nabil Amro, Sandeep Disawal, John Bussan
  • Publication number: 20110293699
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 24, 2011
    Publication date: December 1, 2011
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Publication number: 20110293546
    Abstract: The present invention provides an antibacterial artificial nail composition which can form a cured article having an antibacterial effect by applying the composition on a surface of a natural nail or an artificial nail and polymerizing the composition, using an artificial nail technique of forming a cured article on a natural nail or an artificial nail. Disclosed is an antibacterial artificial nail composition comprising (A) a compound having at least one radical polymerizable unsaturated double bond and an antibacterial group in the molecule and/or (B) an antibacterial filler, (C) a compound having at least one radical polymerizable unsaturated double bond in the molecule, and (D) a polymerization initiator.
    Type: Application
    Filed: August 11, 2011
    Publication date: December 1, 2011
    Inventors: Hisaki TANAKA, Mikito Deguchi
  • Patent number: 8067054
    Abstract: A method of making a drug eluting stent comprises forming a porous stent body surface layer by ion implantation, applying a layer of ceramic particles on the porous layer and compressing the layer of ceramic particles. The layer of ceramic particles can be compressed to successively higher densities. Drugs can be loaded into the layer of ceramic materials at a relatively low density before the layer of ceramic materials is compressed to a higher density to achieve a desired low drug release rate.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: November 29, 2011
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Jan Weber
  • Publication number: 20110284026
    Abstract: A method improving air quality and reducing healthcare-associated infections performed by a cleaning personnel includes the steps of equipping a cleaning cart with a plurality of single-use microfiber cloths and a plurality of microfiber mops, wherein the cleaning cart includes a vacuum cleaning apparatus with an extensible vacuum hose and a plurality of attachments, positioning the cleaning cart outside of an occupied patient room, vacuuming the patient room with the vacuum hose including first and second attachments, disinfecting the surfaces that a patient may contact with a first microfiber cloth soaked in a disinfectant solution, cleaning at least one bathroom fixture with a second microfiber cloth soaked in the disinfectant solution, mopping the floor area including the floor area of the patient restroom with a microfiber mop charged with a neutral cleaner, and placing the microfiber mop in a plastic bag.
    Type: Application
    Filed: June 6, 2011
    Publication date: November 24, 2011
    Applicant: Xanitos, Inc.
    Inventors: Ray Taylor, Graeme Crothall
  • Publication number: 20110288497
    Abstract: A nano-scale device and method of manufacturing and use. The nano-scale device may be used in-vivo and may comprise a fluid path with an inlet microchannel, an outlet microchannel, and a nanochannel. The fluid path comprises bio-robust material. In certain embodiments, the bio-robust material may be coated over a material that is not bio-robust.
    Type: Application
    Filed: May 19, 2011
    Publication date: November 24, 2011
    Applicant: NANOMEDICAL SYSTEMS, INC.
    Inventors: Randy Goodall, Sharath Hosali
  • Publication number: 20110287080
    Abstract: The invention relates to a coating composition for an implantable medical device, a method of coating a medical device and a device coated with the composition.
    Type: Application
    Filed: October 21, 2009
    Publication date: November 24, 2011
    Applicant: SMITH & NEPHEW PLC
    Inventors: David Franklin Farrar, Kadem Gayard Al-Lamee, Jeffrey Nmi Motley
  • Publication number: 20110287167
    Abstract: A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
    Type: Application
    Filed: July 6, 2011
    Publication date: November 24, 2011
    Inventors: Mei Wei, Haibo Qu, Xiaohua Yu
  • Patent number: 8062691
    Abstract: A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: November 22, 2011
    Assignee: Baylor College of Medicine
    Inventors: Mohammad David Mansouri, Rabih O. Darouiche
  • Patent number: 8062692
    Abstract: A method of applying a dental composition to tooth surfaces is provided. The dental composition, comprising polymerizable resin and fluorescing compound, is applied to a tooth surface and cured so that it hardens. The composition is preferably used as a dental sealant that provides a hard, glossy surface finish over a tooth. Upon irradiating the sealant with ultraviolet light, the sealant exhibits a bright fluorescent glow. The sealant reverts immediately to its natural color when it is no longer exposed to the ultraviolet light.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: November 22, 2011
    Inventors: Thomas C. Simonton, Kenneth S. Peterson
  • Patent number: 8063265
    Abstract: A hydrogel having a floatability where from 40% to 90% of a solution and/or suspension to be thickened are thickened starting from the surface of the liquid and the rest of the solution and/or suspension to be thickened is thickened starting from the bottom of the container, a process for preparing the hydrogel and also its use for absorbing blood and/or body fluids, especially in hygiene articles, or for thickening aqueous solutions and/or suspensions, especially for thickening medical wastes.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: November 22, 2011
    Assignee: BASF Aktiengesellschaft
    Inventors: Martin Beck, Volker Frenz, Anna Kowalski, Elisabeth Selzer, Ernst Jürgen Bauer, Harald Keller, Bernhard Steinmetz
  • Publication number: 20110282463
    Abstract: The present invention relates to a medical tissue-binding material, especially a soft tissue-binding material capable of attaching to a soft biological tissue such as a bone reconstruction material or a transdermal terminal, and a method for preparation thereof. In particular, the present invention relates to a medical tissue-binding material which comprises a base material having calcium binding onto the surface, provided that the base material is not titanium or titanium alloy. Also, the present invention relates to a method for preparing a medical tissue-binding material which comprises soaking a base material into a calcium ion containing solution. Introduction of at least one group selected from the group consisting of hydroxyl, carboxyl, sulfonate, amino, silanol and phosphate to the surface of the base material is effective for said method.
    Type: Application
    Filed: September 19, 2008
    Publication date: November 17, 2011
    Inventor: Kunio Ishikawa
  • Publication number: 20110281020
    Abstract: A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet.
    Type: Application
    Filed: May 17, 2011
    Publication date: November 17, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Victoria M. Gong, Stephen D. Pacetti, Anthony S. Andreacchi, Michael Leonard, Binh T. Nguyen, John Stankus, Dan Cox
  • Publication number: 20110281019
    Abstract: A system and method for coating an expandable member of a medical device comprises providing a dispenser in fluid communication with a fluid source with the dispenser having at least one outlet to dispense fluid of the fluid source therefrom. The outlet(s) of the dispenser is positioned proximate a surface of an expandable member, with relative movement between the outlet(s) and the surface of the expandable member established along a coating path, and fluid is dispensed from the dispenser to form a substantially continuous bead of fluid between the at least one outlet and the surface of the expandable member along the coating path, and simultaneously drying the fluid while dispensing the fluid from the dispenser to control flow of fluid on the surface of the expandable member. The fluid source can include a variety of therapeutic agents.
    Type: Application
    Filed: May 16, 2011
    Publication date: November 17, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Victoria M. Gong, Stephen D. Pacetti, Anthony S. Andreacchi, Shih-hsiung Albert Yuan
  • Patent number: 8057813
    Abstract: Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: November 15, 2011
    Assignee: Abbott Laboratories
    Inventors: John L. Toner, Sandra E. Burke, Keith R. Cromack, Randolf von Oepen
  • Patent number: 8057842
    Abstract: A method of coating a microneedle array by applying a coating fluid using a flexible film in a brush-like manner. A method of coating a microneedle array comprising: providing a microneedle array having a substrate and a plurality of microneedles; providing a flexible film; providing a coating solution comprising a carrier fluid and a coating material; applying the coating solution onto a first major surface of the flexible film; performing a transfer step of bringing the first major surface of the flexible film into contact with the microneedles and removing the flexible film from contact with the microneedles; and allowing the carrier fluid to evaporate.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: November 15, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Hye-Ok Choi, Gordon P. Knutson, Moses M. David
  • Patent number: 8057841
    Abstract: The present invention relates to nanofibrous coatings on medical devices such a surgical mesh or stent, wherein the coating is mechanically attached to the device. The principal mechanism for attaching the coating is through causing the fibers to permeate and entangle with the substrate.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: November 15, 2011
    Assignee: University of Akron
    Inventors: Darrell H. Reneker, Daniel J. Smith, Woraphon Kataphinan
  • Patent number: 8057844
    Abstract: Methods for coating an implantable medical device, such as a stent, are provided.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: November 15, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Yung-Ming Chen, Henjen Ho
  • Publication number: 20110274917
    Abstract: A medical device wherein a surface lubricating layer and one of various polymer bases are fixed with each other firmly by a relatively simple technique. The medical device permanently exhibits excellent surface lubricity when in use. The medical device has a lubricating surface when wet, and includes a base layer at least the surface of which is composed of a polymer material, a compound (thiol compound) which is supported on at least a part of the base layer and has a plurality of thiol groups in each molecule, and a surface lubricating layer which covers the thiol compound and is composed of a hydrophilic polymer that has a reactive functional group.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 10, 2011
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Kazuya OMATA, Maeda NAOYUKI, Onishi MAKOTO
  • Publication number: 20110274823
    Abstract: Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
    Type: Application
    Filed: July 18, 2011
    Publication date: November 10, 2011
    Inventors: Roger Labrecque, Geoffrey Moodie, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Suzanne Conroy, Brian Sunter, Georgette Henrich
  • Patent number: RE42982
    Abstract: The present invention relates to medical devices that are inserted or implanted into patients and that have antimicrobial coatings that release free radicals into the vicinity of the device. These devices may have coatings that alter their rate of flow release or elution release of an antibacterial agent from a coating on the device upon external stimulation. The coating should therefore be responsive to external control such as by heating, external RF stimulus, sonic control, visible or ultraviolet light exposure and the like. By having control of the release rate, and in some structures without invasion of the patient by mechanical means in addition to the device itself, the release rate can be in response to need at the implant site. The class of compounds to be released are free radical generating or initiating compounds, or compounds that release free radicals upon immersion or stimulation, the free radicals acting as the antimicrobial agent.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: November 29, 2011
    Inventor: Mark A. Mitchnick