Transferase Other Than Ribonuclease (2.) Patents (Class 435/193)
Transferring phosphorus containing group (e.g., kineases, etc.(2.7)) (Class 435/194)
  • MODIFIED DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20130196373
    Abstract: Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: November 16, 2012
    Publication date: August 1, 2013
    Applicant: SANGAMO BIOSCIENCES, INC.
    Inventor: Sangamo BioSciences, Inc.
  • Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
    Patent number: 8497471
    Abstract: Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: July 30, 2013
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: William F. Haddon, Nigel J. Clarke
  • PRODUCTION OF SECRETED PROTEINS BY FILAMENTOUS FUNGI
    Publication number: 20130189733
    Abstract: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
    Type: Application
    Filed: January 25, 2013
    Publication date: July 25, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: CORNELIS MARIA JACOBUS SAGT, CORNELIS THEODORUS VERRIPS, WALRAVEN HENRY MULLER, NOEL NICOLAAS MARIA ELISABETH VAN PEIJ
  • MODIFIED TRANSKETOLASE AND USE THEREOF
    Publication number: 20130189731
    Abstract: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
    Type: Application
    Filed: July 26, 2012
    Publication date: July 25, 2013
    Applicant: DSM IP Assets B.V.
    Inventors: Michael Hans, Dietmar Laudert, Hans-Peter Hohmann, Martin Lehmann
  • ENZYMATIC CONJUGATION OF POLYPEPTIDES
    Publication number: 20130189287
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 25, 2013
    Applicants: Innate Pharma
    Inventors: Innate Pharma, Paul Scherrer Institut
  • Sporulation-deficient thermophilic microorganisms for the production of ethanol
    Patent number: 8486687
    Abstract: A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: July 16, 2013
    Assignee: TMO Renewables Limited
    Inventors: Anthony Atkinson, Roger Cripps, Kirstin Eley
  • Identification of co-regulation patterns by unsupervised cluster analysis of gene expression data
    Patent number: 8489531
    Abstract: A method is provided for unsupervised clustering of gene expression data to identify co-regulation patterns. A clustering algorithm randomly divides the data into k different subsets and measures the similarity between pairs of datapoints within the subsets, assigning a score to the pairs based on similarity, with the greatest similarity giving the highest correlation score. A distribution of the scores is plotted for each k. The highest value of k that has a distribution that remains concentrated near the highest correlation score corresponds to the number of co-regulation patterns.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: July 16, 2013
    Assignee: Health Discovery Corporation
    Inventors: Asa Ben Hur, Andre Elisseeff, Isabelle Guyon
  • ANCESTRAL SERINE PROTEASE COAGULATION CASCADE EXERTS A NOVEL FUNCTION IN EARLY IMMUNE DEFENSE
    Publication number: 20130177547
    Abstract: The present invention relates to blood coagulation factor XIII (FXIII) for treatment and/or prevention of an infection by a microorganism and/or the symptoms associated with said infection, a pharmaceutical composition comprising a pharmaceutically effective amount of said FXIII, a method for the manufacture of a medicament comprising a pharmaceutically effective amount of said FXIII, and a method of treatment comprising administering to a patient in need a pharmaceutically effective amount of said FXIII.
    Type: Application
    Filed: July 20, 2011
    Publication date: July 11, 2013
    Applicants: HANSA MEDICAL AB, CSL BEHRING GMBH
    Inventors: Heiko Herwald, Ulrich Theopold, Torsten Loof, Matthias Mörgelin, Gerhard Dickneite
  • SULFOTRANSFERASE OF A RED MICROALGA AND USES THEREOF
    Publication number: 20130180012
    Abstract: An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel sulfotransferase is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a polynucleotide encoding a protein which is at least partially encoded by a novel sulfotransferase is also provided. The invention also includes a process for in-vivo and in-vitro making a sulfated polysaccharide from an unsulfated polysaccharide or increasing the sulfur content of an already sulfated polysaccharide.
    Type: Application
    Filed: April 11, 2011
    Publication date: July 11, 2013
    Inventors: Shoshana Arad, Lena Plesser, Yaakov Weinstein
  • Modified DNA polymerases
    Patent number: 8481685
    Abstract: The present invention provides, among other things, modified DNA polymerases containing amino acid alterations based on mutations identified in directed evolution experiments designed to select enzymes that are better suited for applications in recombinant DNA technologies.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: July 9, 2013
    Assignee: Kapa Biosystems
    Inventors: William Bourn, Bjarne Faurholm, John Foskett
  • PROCESSING BIOMASS
    Publication number: 20130164818
    Abstract: Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids.
    Type: Application
    Filed: December 6, 2011
    Publication date: June 27, 2013
    Applicant: XYLECO, INC.
    Inventor: Marshall Medoff
  • BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE
    Publication number: 20130164794
    Abstract: The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 27, 2013
    Applicant: CODEXIS, INC.
    Inventors: John Limanto, Gregory Beutner, Brendan Grau, Jacob Janey, Artis Klapars, Eric Ashley, Hallena R. Strotman, Matthew D. Truppo, Gregory Hughes, Fabien L. Cabirol, Anupam Gohel, Steven J. Collier, Jack Liang, Marissa Mock, Emily Mundorff, Scott Novick, Derek Smith
  • Microorganisms and methods for conversion of syngas and other carbon sources to useful products
    Patent number: 8470566
    Abstract: A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: June 25, 2013
    Assignee: Genomatica, Inc.
    Inventors: John D. Trawick, Mark J. Burk, Anthony P. Burgard
  • INCREASED POLY (ALPHA 1,3 GLUCAN) YIELD USING BORIC ACID
    Publication number: 20130157316
    Abstract: A process for production of poly(?1,3 glucan) from a renewable feedstock, for applications in fibers, films, and pulps. The effect of addition of boric acid in increasing the yield of the desired end products, poly(?1,3 glucan) and fructose, and decreasing formation of the undesired by-product leucrose.
    Type: Application
    Filed: December 19, 2012
    Publication date: June 20, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: E I Du Pont De Nemours And Company
  • METHODS AND COMPOSITIONS FOR OXIDIZING BISPHENOL A
    Publication number: 20130157336
    Abstract: Disclosed are methods, compositions and kits pertaining to polymer coatings that entrap enzymes, specifically enzymes capable of degrading bisphenol A.
    Type: Application
    Filed: December 19, 2011
    Publication date: June 20, 2013
    Applicant: Empire Technology Development LLC
    Inventor: Robert M. Cabrera
  • GLYPHOSATE RESISTANT 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE (EPSP) SYNTHASE
    Publication number: 20130157340
    Abstract: A plant comprising SEQ. ID. NO. 2 or a functional portion thereof, wherein SEQ ID NO. 2 is not native to said plant. A glyphosate resistant grass of economic value comprises a nucleic acid molecule that encodes a EPSPS enzyme. In some embodiments, the nucleic acid molecule comprises a sequence of SEQ. ID. NO. 1, or a functional portion thereof. In some embodiments, the EPSPS enzyme can be a polypeptide molecule comprising an amino acid sequence that is essentially of SEQ. ID. NO. 2, or portion thereof. Embodiments include a DNA construct comprising a SEQ. ID. NO. 1 or a functional portion thereof and transgenic methods for inserting the DNA construct into a plant. Some embodiments include non-transgenic glyphosate resistant turfgrasses.
    Type: Application
    Filed: February 20, 2013
    Publication date: June 20, 2013
    Applicant: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventor: Board of Trustees of Michigan State University
  • Methods for plant transformation using spectinomycin selection
    Patent number: 8466345
    Abstract: The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: June 18, 2013
    Assignee: Monsanto Technology LLC
    Inventors: Brian Martinell, Michael Petersen, David Somers, Yuechun Wan, Edward Williams, Xudong Ye
  • Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
    Patent number: 8465952
    Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: June 18, 2013
    Assignee: CJ Cheiljedang Corporation
    Inventors: Chul Ha Kim, So Young Kim, Young Uk Shin, Hye Won Um, Jin Sook Chang, Young Wook Cho, Han Jin Lee, In Kyung Heo, Chang II Seo, Kwang Ho Na
  • GENES ENCODING A NOVEL TYPE OF LYSOPHOPHATIDYLCHOLINE ACYLTRANSFERASES AND THEIR USE TO INCREASE TRIACYLGLYCEROL PRODUCTION AND/OR MODIFY FATTY ACID COMPOSITION
    Publication number: 20130152230
    Abstract: Described nucleic acid molecules (and corresponding peptides) encode lyso-phosphatidylcholine (LPC) acyltransferases. Over-expression of the LPC acyltransferases in a cell may lead to enhanced production of PUFA, or other unusual fatty acids, and/or to increased oil content in the cell.
    Type: Application
    Filed: January 18, 2013
    Publication date: June 13, 2013
    Applicants: Dow AgroSciences LLC, National Research Council of Canada
    Inventors: Qilin Chen, Jitao Zou, Zhifu Zheng, Jingyu Xu
  • Engineered versions of polysialyltransferases with enhanced enzymatic properties
    Patent number: 8460909
    Abstract: The invention relates to poly-sialyltransferse polypeptides with enhanced solubility and activity and methods of using the poly-sialyltransferases for production of poly-sialylated end products, e.g., oligosaccharides, glycoproteins and glycolipids.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: June 11, 2013
    Assignee: National Research Council of Canada
    Inventors: Warren Wakarchuk, Elizabeth Willis, Michel Gilbert
  • Cell-free system for synthesizing membrane proteins cell free method for synthesizing membrane proteins
    Patent number: 8455231
    Abstract: The invention provides an in vitro method for producing proteins, membrane proteins, membrane-associated proteins, and soluble proteins that interact with membrane-associated proteins for assembly into an oligomeric complex or that require association with a membrane for proper folding. The method comprises, supplying intracytoplasmic membranes from organisms; modifying protein composition of intracytoplasmic membranes from organism by modifying DNA to delete genes encoding functions of the organism not associated with the formation of the intracytoplasmic membranes; generating appropriate DNA or RNA templates that encode the target protein; and mixing the intracytoplasmic membranes with the template and a transcription/translation-competent cellular extract to cause simultaneous production of the membrane proteins and encapsulation of the membrane proteins within the intracytoplasmic membranes.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 4, 2013
    Assignee: Uchicago Argonne, LLC
    Inventors: Philip D. Laible, Deborah K. Hanson
  • Biliverdin from a non-animal source
    Patent number: 8455222
    Abstract: Methods for producing biliverdin in a microorganism, methods for producing biliverdin from a non-animal source, cells for producing biliverdin and methods for producing cells for producing biliverdin are disclosed.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: June 4, 2013
    Assignee: Utah State University
    Inventors: Jon Y Takemoto, Dong Chen
  • ANALYSIS OF METHYLATION SITES
    Publication number: 20130130922
    Abstract: A method for labeling unmethylated CpG dinucleotides within a DNA fragment, and use of the method in profiling of genomic DNA methylation. The present invention further provides modified DNA methyltransferase enzymes and compounds which are capable of being used by the enzymes as cofactors for use in the labeling method.
    Type: Application
    Filed: November 16, 2012
    Publication date: May 23, 2013
    Applicants: Centre for Addiction and Mental Health, Vilnius University
    Inventors: Vilnius University, Centre for Addiction and Mental Health
  • VARIANT LOVD POLYPEPTIDES AND THEIR USES
    Publication number: 20130130351
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: January 31, 2013
    Publication date: May 23, 2013
    Applicant: CODEXIS, INC.
    Inventor: Codexis, Inc.
  • VACCINES AGAINST PREGNANCY-ASSOCIATED MALARIA
    Publication number: 20130129767
    Abstract: The present invention relates to specific regions of the N-terminal portion of the VAR2CSA protein and to the use of such specific regions in the prevention of pregnancy-associated malaria. The invention also provides immunogenic compositions and vaccines that are useful for preventing malaria in pregnant women.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Applicant: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)
    Inventors: Nicaise Tuikue Ndam, Philippe Deloron, Sedami Ursula Alix Carine Gnidéhou, Mickaël Quiviger, Pascal Bigey, Daniel Scherman
  • Modified Forms of Pseudomonas Exotoxin A
    Publication number: 20130121983
    Abstract: Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38 kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.
    Type: Application
    Filed: September 5, 2012
    Publication date: May 16, 2013
    Applicant: Intrexon Corporation
    Inventors: Timothy David JONES, Francis Joseph Carr
  • Eubacterial RNA-Polymerase Mutants With Altered Product Production
    Publication number: 20130122548
    Abstract: The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymererase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a mutant eubacterium and to a use of the mutant eubacterium according to the invention for producing at least one product of interest.
    Type: Application
    Filed: January 22, 2013
    Publication date: May 16, 2013
    Applicant: NOVOZYMES A/S
    Inventor: Novozymes A/S
  • NOVEL ENZYME PROTEIN, PROCESS FOR PRODUCTION OF THE ENZYME PROTEIN THE SAME, AND GENE ENCODING THE ENZYME PROTEIN THE SAME
    Publication number: 20130122566
    Abstract: The present invention relates to a protein having a ?-galactoside-?2,3-sialyltransferase activity but substantially not having any neuraminidase activity, a nucleic acid encoding the enzyme protein, and a method of producing the enzyme using a microorganism transformed with a gene encoding the protein. The protein of the present invention is a modified-type enzyme protein produced by mutating a specific amino acid residue in a ?-galactoside-?2,3-sialyltransferase protein derived from a microorganism belonging to the genus Photobacterium of the family Vibrionaceae and thereby substantially inactivating the neuraminidase activity of the protein.
    Type: Application
    Filed: July 28, 2011
    Publication date: May 16, 2013
    Applicant: JAPAN TOBACCO INC.
    Inventors: Toshiki Mine, Takeshi Yamamoto, Sakurako Katayama
  • Method for reducing 1,2-diglyceride content of an edible oil
    Patent number: 8440435
    Abstract: The present application provides a method of reducing and/or removing diglyceride from an edible oil, comprising admixing an edible oil with an acyl acceptor substrate and a diglyceride:glycerol acyltransferase, wherein the diglyceride:glycerol acyltransferase is characterized as an enzyme which in an edible oil is capable of transferring an acyl group from a diglyceride to glycerol. The diglyceride:glycerol acyltransferase can comprise the amino acid sequence motif GDSX. The present invention also relates to the use of a diglyceride:glycerol acyltransferase in the manufacture of an edible oil, for reducing and/or removing diglyceride from said edible oil and to the use of said enzyme in the manufacture of a foodstuff comprising an edible oil for improving the crystallization properties of said foodstuff.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: May 14, 2013
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Paul Wassell, Jørn Borch Søe, Jørn Dalgaard Mikkelsen, Anna Cecilie Jentoft Kristensen
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 8440434
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: May 14, 2013
    Assignee: Cargill, Incorporated
    Inventors: Paula M. Hicks, Sara C. McFarlan
  • PROCESS FOR PRODUCTION OF FISH PASTE PRODUCT, AND ENZYME PREPARATION FOR MODIFYING FISH PASTE PRODUCT
    Publication number: 20130115332
    Abstract: A fish paste product imparted with firmness and flexibility can be obtained using transglutaminase, an alkali material, and an ascorbic acid compound.
    Type: Application
    Filed: December 27, 2012
    Publication date: May 9, 2013
    Applicant: Ajinomoto Co., Inc.
    Inventor: Ajinomoto Co., Inc.
  • Genetic Markers Associated with Intellectual Disability
    Publication number: 20130116149
    Abstract: Genetic markers associated with intellectual disability as well as compositions, methods and kits for screening for genetic markers intellectual disability, diagnosing intellectual disability and identifying individuals with a predisposition for offspring suffering from intellectual disability are provided.
    Type: Application
    Filed: June 23, 2011
    Publication date: May 9, 2013
    Applicant: CENTRE FOR ADDICTION AND MENTAL HEALTH
    Inventor: John B. Vincent
  • METHOD FOR THE PRODUCTION OF A LYSATE USED FOR CELL-FREE PROTEIN BIOSYNTHESES
    Publication number: 20130115655
    Abstract: The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential translation product that reduces the yield of cell-fee protein biosynthesis, is replaced by the foreign DNA located under a suitable regulatory element, said foreign DNA coding for the essential translation product that additionally contains a marker sequence; b) the organism cloned according to step a) is cultivated; c) the organisms from the culture obtained in step b) are lysed; and d) the essential translation product is eliminated by means of a separation process that is selective for the marker sequence. Also discussed are said lysate and the use thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: May 9, 2013
    Applicant: RINA-NETZWERK RNA TECHNOLOGIEN GMBH
    Inventor: Rina-Netzwerk Rna Technologien Gmbh
  • Renewable chemical production from novel fatty acid feedstocks
    Patent number: 8435767
    Abstract: Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, interesterification, hydroxylation, hydrolysis and saponification are disclosed. Novel oils containing fatty acid chain lengths of C8, C10, C12 or C14 are also disclosed and are useful as feedstocks in the methods of the invention.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: May 7, 2013
    Assignee: Solazyme, Inc.
    Inventors: Scott Franklin, Aravind Somanchi, Karen Espina, George Rudenko, Penelope Chua
  • Polypeptides and biosynthetic pathways for the production of monatin and its precursors
    Patent number: 8435765
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: May 7, 2013
    Assignee: Cargill, Incorporated
    Inventors: Timothy W. Abraham, Douglas C. Cameron, Paula M. Hicks, Sara C. McFarlan, James R. Millis, John Rosazza, David P. Weiner, Lishan Zhao
  • PROTEIN EXHIBITING ACTIVITY OF PYRETHRIN BIOSYNTHETIC ENZYME, GENE ENCODING THE PROTEIN, AND VECTOR BEARING THE GENE
    Publication number: 20130109076
    Abstract: Amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyrethrin by applying such creative techniques to plant bodies with faster growth aiming to provide a method to efficiently produce pyrethrin. A gene encoding a protein consisting of the amino acid sequence of SEQ ID NO: 1. A protein consisting of the amino acid sequence of SEQ ID NO: 2.
    Type: Application
    Filed: December 19, 2012
    Publication date: May 2, 2013
    Applicants: DAINIHON JOCHUGIKU CO., LTD., AN EDUCATIONAL FOUNDATION KINKI UNIVERSITY
    Inventors: AN EDUCATIONAL FOUNDATION KINKI UNIVERSITY, DAINIHON JOCHUGIKU CO., LTD.
  • NOVEL HERBICIDE RESISTANCE GENE
    Publication number: 20130109075
    Abstract: The subject invention provides novel polynucleotides and polypeptides encoding a methyltransferase. The subject invention provides novel plants that express the methyltransferase disclosed herein and are resistant to auxin-based herbicides. The subject invention also provides transgenic plants have been transformed with one or more other herbicide resistance genes such that the plants are resistant to the application of auxin-based herbicides and one or more other herbicides.
    Type: Application
    Filed: December 19, 2012
    Publication date: May 2, 2013
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventor: University of Tennessee Research Foundation
  • Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
    Patent number: 8431122
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: April 30, 2013
    Assignee: Oxthera Intellectual Property AB
    Inventors: Harmeet Sidhu, Qingshan Li, Aaron Blake Cowley, Carl-Gustaf Golander
  • Aminotransferase, gene encoding the same, and methods of using them
    Patent number: 8431378
    Abstract: The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: April 30, 2013
    Assignee: Kaneka Corporation
    Inventors: Noriyuki Ito, Yoshihiko Yasohara
  • ?1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same
    Patent number: 8431365
    Abstract: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with ?1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 30, 2013
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hisashi Narimatsu, Akira Togayachi, Niro Inaba, Toru Hiruma, Yasuko Ishizuka
  • Methods of producing C4 dicarboxylic acids
    Patent number: 8431377
    Abstract: Methods of producing C4 dicarboxylic acids are disclosed. Nucleotide sequences encoding pyruvate carboxylase and uses of such nucleotide sequences in the production of C4 dicarboxylic acids are further disclosed.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: April 30, 2013
    Assignee: Archer Daniels Midland Company
    Inventors: Beth Fatland-Bloom, John P. Rayapati
  • Chloramphenicol resistance selection in
    Patent number: 8431382
    Abstract: The present invention relates to a modified Bacillus licheniformis host cell, wherein one or more naturally occurring chromosomal chloramphenicol acetyl transferase encoding gene(s), cat, has been inactivated. The inactivation of the chromosomal cat gene(s) allows the use of chloramphenicol as an efficient selective agent in methods for DNA introduction into the modified cell.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: April 30, 2013
    Assignee: Novozymes A/S
    Inventor: Steen Troels Jorgensen
  • METHYLTRANSFERASE NUCLEIC ACIDS AND POLYPEPTIDES
    Publication number: 20130104258
    Abstract: This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode methyltransferase polypeptides from a Papaver somniferum cultivar; and uses in the production of noscapine and identification of poppy cultivars that include the genes that comprise said nucleic acid molecules.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 25, 2013
    Applicant: GlaxoSmithKline Australia Pty Limited
    Inventors: Thilo Hans Winzer, Tracy Carol Walker, Ian Alexander Graham
  • Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme
    Patent number: 8426179
    Abstract: Peptides and conjugates thereof comprising one or more bioactive agents which can be coupled to a tissue via a transglutaminase and related methods.
    Type: Grant
    Filed: September 2, 2008
    Date of Patent: April 23, 2013
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Marsha Ritter-Jones
  • Acyltransferases and Uses Thereof in Fatty Acid Production
    Publication number: 20130097733
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucletides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Application
    Filed: June 21, 2011
    Publication date: April 18, 2013
    Applicant: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • YARROWIA PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE PROMOTER REGIONS FOR GENE EXPRESSION IN YEAST
    Publication number: 20130089911
    Abstract: Promoter regions associated with the Yarrowia lipolytica peroxisomal 2,4-dienoyl-CoA reductase (SPS19) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 11, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: QUINN QUN ZHU, SEUNG-PYO HONG
  • BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL
    Publication number: 20130089898
    Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 11, 2013
    Applicant: CODEXIS, INC.
    Inventors: Fabien Cabirol, Anupam Gohel, Seong Ho Oh, Derek Smith, Brian Wong, James Lalonde
  • MARKER FOR DETECTION AND/OR DISCRIMINATION OF NON-ALCOHOLIC STEATOHEPATITIS, METHOD FOR DETECTION AND/OR DISCRIMINATION OF NON-ALCOHOLIC STEATOHEPATITIS, AND KIT FOR USE IN THE METHOD
    Publication number: 20130089871
    Abstract: The detection of a non-alcoholic steatohepatitis patient and the accurate discrimination between a normal person and a non-alcoholic steatohepatitis patient can be achieved by measuring alanine-glyoxylate amino transferase in a sample.
    Type: Application
    Filed: June 13, 2011
    Publication date: April 11, 2013
    Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NITTOBO MEDICAL CO., LTD., NITTO BOSEKI CO., LTD.
    Inventors: Fumio Nomura, Motoi Nishimura, Katsuhiro Katayama, Iwao Kiyokawa
  • YEAST STRAINS MODIFIED IN THEIR SOPHOROLIPID PRODUCTION AND USES THEREOF
    Publication number: 20130089892
    Abstract: The present invention relates to yeast species which are normally capable of producing sophorolipids but which are modified in such way that they are incapable producing the latter compounds. These sophorolipid-negative strains surprisingly display equal growth characteristics and biomass formation as their wild type counterparts and are hence useful for the production of compounds such as recombinant proteins, glycolipids, polyhydroxyalkanoates and carotenoides. In addition, the present invention discloses two glucosyltransferase genes with key-functions in sophorolipid production.
    Type: Application
    Filed: June 10, 2011
    Publication date: April 11, 2013
    Applicant: Universiteit Gent
    Inventors: Wim Soetaert, Sofie De Maeseneire, Karen Saerens, Sofie Roelants, Inge Van Bogaert
  • YARROWIA N-ALKANE-HYDROXYLATING CYTOCHROME P450 PROMOTER REGIONS FOR GENE EXPRESSION IN YEAST
    Publication number: 20130089910
    Abstract: Promoter regions associated with the Yarrowia lipolytica n-alkane-hydroxylating cytochrome P450 (ALK2) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 11, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Quinn Qun Zhu