Oxygen Containing Patents (Class 436/127)
  • Patent number: 8257978
    Abstract: Provided are novel technical means for obtaining useful knowledge in practical application of antioxidation action of dissolved hydrogen and in practical application of active oxygen scavenging action in water. Based on the temporal profile of the difference between the dissolved oxygen amount measured with forcibly dissolving hydrogen and the dissolved oxygen amount measured with blowing any other gas than hydrogen, the reaction between dissolved hydrogen and dissolved oxygen is quantitatively evaluated. Based on the temporal profile of the difference between the dissolved oxygen amount measured with making a photosensitizing dye contained in water and with forcibly dissolving hydrogen therein, and the dissolved oxygen amount measured without making a photosensitizing dye contained in water and with forcibly dissolving hydrogen therein, the reaction between dissolved hydrogen and dissolved oxygen is quantitatively evaluated.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: September 4, 2012
    Assignees: Eureka-Lab Inc., Seiji Katayama
    Inventors: Seiji Katayama, Yumiko Katayama
  • Patent number: 8241911
    Abstract: A calibration card and method of using the card to calibrate an analytical instrument capable of reading a photoluminescent oxygen probe. The card includes at least (a) a first mass of an oxygen sensitive photoluminescent dye retained within a hermetically sealed space so as to isolate the dye from environmental oxygen, and in fluid communication with an activated metal-air battery whereby any oxygen permeating into the hermetically sealed space is quickly consumed by the battery, and (b) a second mass of an oxygen sensitive photoluminescent dye in fluid communication with the environment whereby the second mass of photoluminescent dye is exposed to an environmental concentration of oxygen.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: August 14, 2012
    Assignee: Mocon, Inc.
    Inventors: Timothy A. Ascheman, Daniel W. Mayer, Stephen D. Tuomela
  • Patent number: 8222041
    Abstract: A high electron mobility transistor (HEMT) capable of performing as a CO2 or O2 sensor is disclosed, hi one implementation, a polymer solar cell can be connected to the HEMT for use in an infrared detection system. In a second implementation, a selective recognition layer can be provided on a gate region of the HEMT. For carbon dioxide sensing, the selective recognition layer can be, in one example, PEI/starch. For oxygen sensing, the selective recognition layer can be, in one example, indium zinc oxide (IZO). In one application, the HEMTs can be used for the detection of carbon dioxide and oxygen in exhaled breath or blood.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: July 17, 2012
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Fan Ren, Stephen John Pearton
  • Patent number: 8193001
    Abstract: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: June 5, 2012
    Assignee: Applied Biosystems, LLC
    Inventors: Matthew M. Winkler, Richard C. Conrad
  • Patent number: 8187891
    Abstract: The present invention provides a method for detection or determination of vitamin C by luminescence that employs a redox-responsive fluorogenic probe consisting of porphyrin or phthalocyanine with a nitroxide radical(s), or that employs a liposome preparation comprising the said redox-responsive fluorogenic probe. The present method can overcome the problems of prior art methods, and in particular, are applicable for bioimaging to allow elucidation of the behavior of vitamin C in vivo.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: May 29, 2012
    Assignee: The University of Tokyo
    Inventors: Kazuyuki Ishii, Kensuke Kubo, Kikuo Komori, Yasuyuki Sakai
  • Patent number: 8158077
    Abstract: The present invention provides a composition for detecting an object substance (X). This detection composition contains a gel (Y). The gel (Y) contains a colorable aqueous solution (A) that can be colored upon contact with the object substance (X), and a crosslinked polymer (B). This composition is preferably used to evaluate packaging materials.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: April 17, 2012
    Assignee: Kuraray Co., Ltd.
    Inventors: Mie Kanehara, Miki Yamasaki, Satoru Koike, Tomoyuki Watanabe
  • Patent number: 8153439
    Abstract: The presently-disclosed subject matter provides sensors and methods for detecting volatile organic compounds (VOCs) by determining the conductivity of a chemiresistant film upon exposure to VOCs, including for example chemiresistant films comprised of surfactant-coated metal alloy nanoparticles.
    Type: Grant
    Filed: July 26, 2008
    Date of Patent: April 10, 2012
    Assignee: University of Lousiville Research Foundation, Inc.
    Inventors: Francis P. Zamborini, Francisco J. Ibanez
  • Publication number: 20120064635
    Abstract: An energy content meter can spectroscopically quantify oxidation products after oxidation of a combustible mixture. The measured oxidation product concentrations or mole fractions can be converted to an energy content of the un-oxidized combustible mixture using a conversion factor that relates oxygen consumption during oxidation of the combustible mixture to the energy content of the combustible mixture.
    Type: Application
    Filed: November 21, 2011
    Publication date: March 15, 2012
    Inventors: Alfred Feitisch, Xiang Liu, Xin Zhou, Dale Langham, Charles F. Cook
  • Patent number: 8114382
    Abstract: The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: February 14, 2012
    Assignee: General Electric Company
    Inventors: Cristina Abucay Tan Hehir, Stephen Johnson Lomnes, Kenneth Michael Fish, Tiberiu Mircea Siclovan, Michael Christopher Montalto, Tunchiao Hubert Lam
  • Patent number: 8114674
    Abstract: The present invention relates to a method for determining whether or not a mammal is affected with a lung cancer. The method for determining whether or not a mammal is affected with a lung cancer of the present invention includes the steps of: (a) detecting whether or not anthranilic acid is contained in the urine excreted from the mammal; and (b) determining that the mammal is affected with a lung cancer when the anthranilic acid is detected as being contained in the urine.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: February 14, 2012
    Assignee: Panasonic Corporation
    Inventors: Yuki Sugibayashi, Yosuke Hanai
  • Publication number: 20120028364
    Abstract: Analytical systems and methods are provided for simultaneously dispensing metered volumes of fluids at different rates and mixing the fluids to generate a mixed sample having the fluids in proportion to the different rates at which they were dispensed. In some cases two or more of the fluids are premixed prior to mixing with other fluids. In some cases a use composition and diluent are simultaneously dispensed at different rates and premixed to form a diluted sample. One or more reagents may be mixed with the diluted sample and the sample mixture can be analyzed to determine characteristics of the use composition.
    Type: Application
    Filed: August 2, 2010
    Publication date: February 2, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Paul R. Kraus, William M. Christensen
  • Publication number: 20120021526
    Abstract: Biological fluid samples containing proteins (e.g., blood plasma or saliva) are prepared for isotopic analysis by precipitating the proteins while leaving the isotopic ratio unaffected. This precipitation can involve adding metal ions, salts, organic solvents, or organic polymers. The sample is then centrifuged to allow transfer of the supernatant for isotopic analysis, e.g. by tunable diode laser absorption spectrometry to obtain a quantitative measure of the 2H and 18O isotope levels in the water relative to reference standards.
    Type: Application
    Filed: July 26, 2011
    Publication date: January 26, 2012
    Inventors: Douglas Steven Baer, Elena Simone Franklin Berman, Manish Gupta, David A. Wagner, Daniel L. Bolt, Susan Lauren Fortson
  • Patent number: 8101136
    Abstract: The present invention relates to a rapid method for estimation of Chemical Oxygen Demand (COD) of water, COD is an important parameter for determining the extent of pollution in water bodies, the basic principle of COD estimation is not much different from prior art but the time taken is reduced considerably and the results are equally sensitive and reproducible as other methods and the method used to generate data on the performance of effluent treatment plants in remote areas or rural areas, it also provide regular and sequential information on the quality of effluent generated by food processing industries.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: January 24, 2012
    Assignee: Council of Scientific and Industrial Research
    Inventors: Vipin Chandra Kalia, Vikas Sonakya, Neena Raizada, Arvind Purshottam Joshi
  • Patent number: 8093055
    Abstract: A calibration tool for use in combination with a photoluminescent oxygen-sensitive working probe and an analytical instrument capable of reading the working probe. The calibration tool is effective for achieving two-point calibration of the analytical instrument, and includes at least first and second solid state compositions having different sensitivities to oxygen. The first composition is an oxygen-sensitive photoluminescent dye that is the same as that in the working probe, embedded within an oxygen-permeable carrier matrix that is the same as that in the working probe. The second composition is an oxygen-sensitive photoluminescent dye that is the same as that in the first composition, embedded within a carrier matrix that is different from that in the first composition. The oxygen sensitivity of the second composition is less than the oxygen sensitivity of the first composition.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: January 10, 2012
    Assignees: Mocon, Inc., Luxcel Biosciences, Ltd.
    Inventors: Daniel W. Mayer, Dmitri Boris Papkovsky
  • Publication number: 20120002323
    Abstract: Disclosed is a method for inspecting a magnetic recording medium in which the adhesion (transfer) of contaminants or corrosive materials to a magnetic head can be prevented. Specifically disclosed is a method for inspecting a magnetic recording medium including a non-magnetic substrate and additionally comprising at least a magnetic layer, a protective layer and a lubricant layer all provided on the non-magnetic substrate. The method is characterized by including exposing the magnetic recording medium to an atmosphere containing a siloxane and determining the resistance of the magnetic recording medium against environmental substances based on the amount of the siloxane attached to the surface of the magnetic recording medium.
    Type: Application
    Filed: March 16, 2010
    Publication date: January 5, 2012
    Applicant: Showa Denko K.K.
    Inventors: Junya Kato, Yoshihiko Maruyama
  • Patent number: 8084264
    Abstract: A method for quantifying the presence of naphthenic acids in a hydrocarbon-comprising liquid that includes: contacting a hydrocarbon-comprising liquid with gaseous ammonia; isolating a reaction product produced by the contacting step; and analyzing the reaction product for the presence of naphthenates using a mass spectrometry technique. The naphthenic acids known to form commercial naphthenate deposits can be (i) ions of tetraprotic carboxylic acids having molecular weights ranging from 1225 to 1270 Daltons, (ii) n-alkyl or branched carboxylic acids having molecular weights ranging from 250 to 650 Daltons, or (iii) both.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: December 27, 2011
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Alan G. Marshall, Priyanka Juyal, Mmilili M. Mapolelo, Ryan P. Rodgers
  • Patent number: 8067242
    Abstract: The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid throughthe formation of an ion of mass to charge ratio (m/z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: November 29, 2011
    Inventors: Valdemir Melechco Carvalho, Fernando Kok
  • Patent number: 8048677
    Abstract: The invention relates to a sensor board comprising a plate-like body comprising a body material and having two surfaces substantially parallel to each other, and at least one optical sensor and at least one non-optical sensor, the sensors being positioned at the same surface of the body, wherein the body includes a first area having a thickness D1 of the body material and a second area having a thickness D2 of the body material, where D1>D2>0, the at least one optical sensor being positioned at the second area.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: November 1, 2011
    Assignee: Radiometer Medical ApS
    Inventor: Michael Svendsmark Hansen
  • Patent number: 8034624
    Abstract: A sampling device for analysis of a substance which is chosen from the group consisting of isocyanates, aminoisocyanates, amines, and isothiocyanates, and which is present in an air flow intended to pass through the sampling device is disclosed, as well as a method for the production of said sampling device, and a method for the analysis of said substance in the air flow.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: October 11, 2011
    Assignee: Provtagaren AB
    Inventors: Gunnar Skarping, Marianne Dalene
  • Patent number: 8021886
    Abstract: The present disclosure relates to a method for assessing if a patient is affected with a lung cancer. The method includes analyzing the presence and amount of cyclohexanone contained in the urine excreted from the patient and determining if the presence and amount of cyclohexanone is indicative of lung cancer.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: September 20, 2011
    Assignee: Panasonic Corporation
    Inventors: Yosuke Hanai, Hiroaki Oka
  • Patent number: 8017404
    Abstract: The level of a steroid hormone, including estrogen, in the stratum corneum of the skin is assayed by LC-MS analysis of a steroid hormone in the stratum corneum of the skin collected by a tape stripping method. This allows the concentration in the skin of the steroid hormone, including estrogen which has an important effect on the state of the skin, to be easily measured.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: September 13, 2011
    Assignee: Kao Corporation
    Inventors: Noriko Haketa, Shingo Kakuo, Seijiro Honma
  • Patent number: 8008084
    Abstract: The present invention relates to a method for determining whether or not a mammal is affected with a lung cancer. The method for determining whether or not a mammal is affected with a lung cancer of the present invention includes the steps of: (a) measuring a concentration of 2-hydroxy-3-methylbutyric acid contained in the urine excreted from the mammal; and (b) determining that the mammal is affected with a lung cancer if the concentration measured in the step (a) is 13.2 ?M or more.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: August 30, 2011
    Assignees: Panasonic Corporation, Monell Chemical Senses Center
    Inventors: Yosuke Hanai, Yuki Sugibayashi
  • Patent number: 8003400
    Abstract: The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: August 23, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Uwe Kobold, Thomas Duelffer, Michael Grol, Rupert Herrmann, Herbert Von der Eltz, Leopold Von Proff
  • Patent number: 7993931
    Abstract: Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic acid through processing required for its detection, such as by mass spectrometry. The methods of the invention are useful for diagnosing inborn errors of metabolism in an individual by quantitating signature organic acids in body fluids such as urine or plasma.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: August 9, 2011
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Su Chen
  • Publication number: 20110183420
    Abstract: A molecule identification and quantitation method is provided wherein a mass tag is conjugated to an analyte and the signature ion of the mass tag remains attached to the analyte after tandem mass spectrometry fragmentation (MS-MS or MS2). Rather than losing the signature ion, a mass-balance part of the structure can be lost as a charge neutral group under tandem mass spectrometry fragmentation. The signature ion can be used for quantitation and, upon further fragmentation, can also provide ion-signals characteristic of the analyte and useful in identifying the analyte. In some embodiments, the ion-signals generated from a third mass spectrometry fragmentation (MS3) can be compared with a known mass spectrum, for example, from a look-up table, from a library, or from a database, to provide an unambiguous identification of the analyte.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 28, 2011
    Inventors: Subhakar DEY, Subhasish PURKAYASTHA
  • Patent number: 7981679
    Abstract: An apparatus and method for monitoring and controlling microbiological activity in a process stream by measuring dissolved oxygen is disclosed.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: July 19, 2011
    Assignee: Nalco Company
    Inventor: Laura E. Rice
  • Patent number: 7972868
    Abstract: Provided are methods of detecting the presence or amount of a dihydroxyvitamin in D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydroxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: July 5, 2011
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Anne Caston-Balderrama, Richard E. Reitz
  • Patent number: 7955861
    Abstract: The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: June 7, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Cassandra L. Fraser, Guoqing Zhang, Jianbin Chen
  • Publication number: 20110111515
    Abstract: A reagent for measurement of reactive oxygen, which can be used with a light of the near infrared region showing superior biological tissue permeability, wherein (i) a first cyanine compound residue and a second cyanine compound residue are bound to each other, (ii) the first cyanine compound residue has a property that it easily reacts with a reactive oxygen species and is thereby decomposed, and (iii) the second cyanine compound residue either equals or surpasses the first cyanine compound residue in its stability to the reactive oxygen species, and the first cyanine compound residue acts as a quenching group for the second cyanine compound residue.
    Type: Application
    Filed: February 27, 2009
    Publication date: May 12, 2011
    Inventors: Tetsuo Nagano, Hirotatsu Kojima, Daihi Oushiki
  • Publication number: 20110091982
    Abstract: Provided herein are methods of detecting anions in solution. In particular, the methods can be used to detect trace anions in solution. For example, the anions can be present in an amount of between about 500 femtomoles to about 10 millimoles.
    Type: Application
    Filed: October 19, 2010
    Publication date: April 21, 2011
    Inventors: Stephen DiMagno, Ronald Cerny
  • Publication number: 20110081729
    Abstract: The detecting and monitoring of solid structure or phase transformation, such as those used for testing the formation of gas hydrates and their inhibition by chemical additives may be conducted in a multi-test assembly of laboratory bench scale loops. The test loop contains a fluid that includes water and hydrate-forming guest molecules such as methane, ethane, carbon dioxide and the like at hydrate-forming conditions of low temperature and high pressure. A small bit or “pig” may be circulated through the test loop at variable speeds to circulate the fluid in the loop. The pig may be moved or impelled through the test loop remotely. The exterior of the pig and/or the interior of the loop may be smooth and/or have a friction-reducing coating thereon to facilitate movement of the pig through the loop. The formation of hydrates may be monitored with consistent and reproducible results.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 7, 2011
    Applicant: Baker Hughes Incorporated
    Inventor: Jun Tian
  • Publication number: 20110070166
    Abstract: Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or no fluorescence due to the disrupted ? conjugation. However, upon reaction with ROS, the reduced dyes are oxidized, regenerating the extended ? conjugation and causing a substantial increase in fluorescence intensity. In many case, the oxidized dye is generally membrane impermeable. However, upon reduction, many of the reduced dyes are membrane permeable. Thus, reduced dyes can accumulate in cells and/or tissue to amplify the signal. Once inside the cell or tissue, the reduced dye is reoxidized upon reaction with ROS, and the oxidized dye again becomes membrane impermeable, trapping the dye within the cell. The reduced dyes can be used to image ROS, such as hydroxide radical and superoxide, in serum, cell cultures, tissue explants, and in vivo.
    Type: Application
    Filed: September 28, 2010
    Publication date: March 24, 2011
    Inventors: Niren Murthy, W. Robert Taylor, Kousik Kundu, Sarah F. Knight, Sungmun Lee
  • Publication number: 20110059462
    Abstract: An automated system for concentrating potentially harmful substances from various water types or other non-viscous liquids to facilitate detection of those substances is disclosed herein. The automated system comprises a water pressure driven or pump driven concentration unit that filters the test fluid through a hollow-fiber filter. Material collected on the filter is backflushed into a collection vessel by passing a small volume of sterile solution through the filter in the reverse direction. The automated system can be configured to be portable or to be integrated into a continuous liquid stream for online monitoring of test fluids. Optionally, an electronic signal at the end of the backflush sequence triggers a detector, such as an automated array biosensor, to begin processing and analyzing the sample.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Inventors: Daniel V. Lim, Elizabeth A. Kearns, Stephaney D. Leskinen, Sonia Magaña
  • Patent number: 7901948
    Abstract: The invention relates to the use of molecular tweezers as sensitive materials in chemical sensors intended to detect or assay organic compounds in the vapour state, and in particular nitro compounds. These molecular tweezers correspond to the general formula (I): in which: MC1 and MC2 represent macrocycles; p and q are equal to 0 or 1; X and Y are optionally substituted C1 to C10 alkylene groups; while E represents an optionally substituted cyclic or heterocyclic spacer group; and in which MC1 and MC2 are positioned facing each other. Fields of application: detection of explosives, control and monitoring of atmospheric pollution and of the quality of ambient air in relatively confined spaces, and monitoring of industrial sites.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: March 8, 2011
    Assignee: Commissariat A l'Energie Atomique
    Inventors: Lionel Hairault, Pierre Montmeat, Eric Pasquinet, Jean-Michel Barbe, Stéphane Brandes, Franck Denat, Claude Gros, Roger Guilard
  • Publication number: 20110039346
    Abstract: The present invention relates to a drug detection device for detecting the presence of a date rape drug in a beverage comprising: a straw; and a chemical reagent, where said chemical reagent coats the surface of the straw and changes color upon contact with a date rape drug. In one exemplary embodiment, the drug detection device may be used to test for Gamma Hydoxybutyrate (GHB) or ROHYPNOL® (Flunitrazepam). A stirring straw may be used as a component of the drug detection device as opposing to a conventional straw. The present invention also includes a method of date rape drug detection comprising the steps of: coating a stirring device with a chemical reagent; inserting the stirring device in a beverage; and observing the stirring device to determine an indication of the presence of a date rape drug.
    Type: Application
    Filed: August 13, 2009
    Publication date: February 17, 2011
    Inventors: Michael BRADLEY, Anthony LEWIS
  • Patent number: 7858380
    Abstract: A light modifying ceramic composition comprises an oxygen permeable sol-gel matrix and a lumophore held on the matrix. In particular, the lumophore of the invention is a hexanuclear molybdenum/tungsten core having 12 anionic ligands and two ligands that are uncharged. Uncharged ligands include organic nitriles, organic phosphines, and organic arsines. In one embodiment, the ceramic composition containing the lumophore and the sol-gel matrix is applied to the end of an optical fiber to provide a remote oxygen sensor. The sensors are useful for in situ biological monitoring of oxygen either in vivo or in vitro, and in time dependent control of combustion processes such as an automobile or power plant.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: December 28, 2010
    Assignee: Board of Trustees of Michigan State University
    Inventors: Gregory L Baker, Ruby N Ghosh, D J Osborn, III
  • Patent number: 7851221
    Abstract: The invention provides a system for designing, operating, monitoring and/or diagnosing a chemical reaction, particularly a hydrotreating process, using a fixed bed catalytic reactor.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: December 14, 2010
    Assignee: Exxonmobilchemical Patents Inc.
    Inventors: Ronald D. Garton, David G. Woods, Hans G. Korsten, Pierre J. Osterrieth, Brian C. McClaine
  • Patent number: 7829342
    Abstract: A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3 C—H bond oxidation. The tetradentate ligand may include a N-heterocyclic-N,N?-bis(pyridyl)-ethane-1,2-diamine group or a N,N?-bis(heterocyclic)-N,N?-bis(pyridyl)-ethane-1,2-diamine group. The composition can be used in combination with H2O2 to effect highly selective oxidations of unactivated sp3 C—H bonds over a broad range of substrates. The site of oxidation can be predicted, based on the electronic and/or steric environment of the C—H bond. In addition, the oxidation reaction does not require the presence of directing groups in the substrate.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: November 9, 2010
    Assignee: The Board of Trustees of the Universiy of Illinois
    Inventors: M. Christina White, Mark S. Chen
  • Patent number: 7820962
    Abstract: An ion mobility spectrometer has a drift chamber (1) with an inlet (2) at one end by which a gas or vapor being analyzed is supplied to the chamber. After ionization, molecules are admitted through a gate 8 and flow along a drift region (9) to a collector plate (11). A drift gas is flowed through the drift region against the flow of ionized molecules and is circulated along a flow path (31, 32, 40) and (30), which includes a chamber (50) including a dopant. The dopant is 2,4-pentanedione, which has been found to enhance the detection of a number of compounds especially toxic industrial chemicals and nitrogen compounds, such as those present in the breath of mammals.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: October 26, 2010
    Assignee: Smiths Detection - Watford Limited
    Inventors: Paul Grant Wynn, Henry Paul McIntyre
  • Patent number: 7815859
    Abstract: The present invention is relates to an apparatus and method for the determination of the oxygen gas permeability of a polymer. In one embodiment, the present invention relates to an apparatus and method for determining the oxygen gas permeability of a polymer membrane (e.g., a polydimethylsiloxane and/or polysiloxane polymer or copolymer). In still another embodiment, the present invention relates to oxygen gas permeable polymer compositions.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: October 19, 2010
    Assignee: The University of Akron
    Inventors: Joseph P. Kennedy, Gabor Erdodi
  • Publication number: 20100261060
    Abstract: Provided is an olivine-type lithium iron phosphate having a composition represented by Formula I, comprising 0.1 to 5% by weight of Li3PO4, and comprising no Li2CO3 or, if present, comprising Li2CO3 in an amount less than 0.25% by weight: Lii+aFe1?xMx(PO4?b)Xb (I) wherein M, X, a, x and b are as defined above. The lithium iron phosphate comprises no lithium carbonate (Li2CO3) or, if present, comprises the Li2CO3 in an extremely small amount, and comprises Li3PO4 having superior electrochemical stability, thermal stability and ionic conductivity, thus advantageously imparting high-temperature and storage stability as well as stability and rate properties to lithium secondary batteries, when used as a cathode active material for the lithium secondary batteries.
    Type: Application
    Filed: February 19, 2010
    Publication date: October 14, 2010
    Applicant: LG CHEM, LTD.
    Inventors: Sanghoon CHOY, Yong Tae Lee, Hong-Kyu Park, Soo Min Park, Hyo-shik Kil, Cheol-Hee Park
  • Publication number: 20100255597
    Abstract: Described are CO sensors, methods for making the CO sensors, and methods for using the CO sensors. An exemplary CO sensor includes a ruthenium oxide present in a form having one or more surfaces, a pair of conductive electrodes operatively connected to a surface of the ruthenium oxide, and an electrical device operatively connected to the pair of conductive electrodes. The gas mixture contacts at least one surface of the ruthenium oxide during operation of the sensor and the electrical device applies a constant potential (or current) and measures a current (or potential) between the pair of conductive electrodes, from which a resistance can be derived as the gas mixture contacts at least one surface of the ruthenium oxide. The ruthenium oxide may have varying levels of hydration. Furthermore, the sensor operates at a temperature range of from about 25° C. to about 300° C.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 7, 2010
    Inventors: Prabir K. Dutta, Adedunni D. Adeyemo
  • Patent number: 7799573
    Abstract: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant, wherein the sample may react and cause light emission from the reactant. Advantages of the present invention may include the simplification of devices for determination of peroxide-based explosives, wherein the devices are portable and, in some cases, disposable. Other advantages may include relative ease of fabrication and operation.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: September 21, 2010
    Assignee: Normadics, Inc.
    Inventors: Robert Deans, Aimee Rose, Kevin M. Bardon, Lawrence F. Hancock, Timothy M. Swager
  • Patent number: 7781229
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are water-soluble acridanes, enhancer coupled acridanes, bis and trisacridanes as well as acridane-(1,2)-dioxetanes. Among the new (1,2)-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The (1,2)-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. An aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: August 24, 2010
    Assignee: Michigan Diagnostics, LLC
    Inventors: Brij Pal Giri, Dinesh Dagli, Pritam Singh
  • Patent number: 7781221
    Abstract: A system configured to determine information related to one or more gaseous analytes in a body of gas comprises a luminescable material, one or more emitters, one or more photosensitive detectors, and a processor. The emitters emit amplitude modulated electromagnetic radiation onto the luminescable medium in communication with a body of gas causing luminescence in the luminescable medium. The photosensitive detectors receive the amplitude modulated electromagnetic radiation generated by the luminescence of the luminescable medium and generate one or more output signals, at least one of the output signals indicating the intensity of the received electromagnetic radiation. The processor receives the output signals and determines information related to one or more gaseous analytes in the body of gas. The determination of information related to the one or more gaseous analytes may comprise compensating for a delay that varies as a function of the intensity of the received electromagnetic radiation.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: August 24, 2010
    Assignee: RIC Investments, LLC
    Inventor: Cord Mueller
  • Publication number: 20100210023
    Abstract: The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal disease by detecting metabolites found in the saliva of an individual. Finally, the present invention provides kits for the detection of salivary metabolites useful in the diagnosis or prognosis of oral cancer and periodontal disease in an individual.
    Type: Application
    Filed: September 18, 2009
    Publication date: August 19, 2010
    Inventors: David T.W. Wong, Masaru Tomita, Masahiro Sugimoto, Akiyoshi Hirayama, Tomoyoshi Soga
  • Publication number: 20100203649
    Abstract: An optochemical sensor element 9 measures gaseous or dissolved analytes, in particular of oxygen. The sensor element 9 includes a fluorophor 25 that is immobilized in a polymer matrix 23. The polymer matrix itself is formed of a polymer with a non-aromatic backbone. The sensor element 9 is useful in a measuring device.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 12, 2010
    Applicant: Mettler-Toledo AG
    Inventor: Rolf Thrier
  • Patent number: 7749768
    Abstract: The invention is a method of measuring oxygen concentration in a package having an oxygen sensitive product disposed therein. The method includes exposing a luminescent compound that is disposed in an interior of the package to light having a wavelength that is absorbed by the luminescent compound so that the luminescent compound is promoted into an excited state. When the exposure of the light is terminated, the excited luminescent compound emits light that is detectable by a detector positioned outside of the package. The intensity of the emitted light is inversely proportional to the oxygen concentration and is used in conjunction with mathematical function that describes the luminescent intensity of the luminescent compound as a function of oxygen concentration and temperature to calculate the oxygen concentration. The method may be used to verify and track the oxygen concentration of a package as it moves through a distribution system.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: July 6, 2010
    Assignee: Cryovac, Inc.
    Inventors: Marvin Russell Havens, Charles Rice Barmore
  • Publication number: 20100105146
    Abstract: A system for monitoring water quality in a water distribution system having a plurality of metering end points (E) for measuring consumption includes a plurality of chemical biological and environmental sensors (S1, S2) disposed in a distribution system near or within the distribution end points (A, B), with the sensors (S1, S2) generating electrical signals through a network (G) that can be processed and communicated to a collection station (D) from the metering end points (E).
    Type: Application
    Filed: July 15, 2008
    Publication date: April 29, 2010
    Inventors: Richard A. Meeusen, Gregory M. Gomez, J. Donald Faber, Dennis J. Webb, Daniel d. Zandron, Mark Lazar
  • Patent number: 7704751
    Abstract: A method of detecting organic vapors is described. More particularly, the method involves the use of an analyte sensor that contains a polymeric material having a relatively large intrinsic porosity and that is capable of fluorescence in the visible region of the electromagnetic spectrum. The method further includes exposing the analyte sensor to an environment that may contain an organic vapor and monitoring the analyte sensor for a change in a fluorescence signal. Although the organic vapor itself typically does not fluoresce in the visible wavelength range, presence of an organic vapor can alter the fluorescence signal of the analyte sensor.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: April 27, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: Michael C. Palazzotto, Neal A. Rakow, Michael S. Wendland