Oxygen Containing Patents (Class 436/127)
  • Publication number: 20020137221
    Abstract: There is provided a method for preserving an oxygen infusion comprising a suspension containing hemoglobin or a heme derivative contained in molecular assemblies suspended in a aqueous medium, comprising modifying the molecular assemblies with polyoxyethylene, and making the hemoglobin or the heme derivative to a deoxy-type by removing oxygen from the suspension.
    Type: Application
    Filed: March 7, 2002
    Publication date: September 26, 2002
    Applicant: Japan Science and Technology Corporation
    Inventors: Eishun Tsuchida, Hiromi Sakai, Kenichi Tomiyama, Shinji Takeoka, Keitaro Sou
  • Publication number: 20020132359
    Abstract: A means for dispensing a single unit dose of an oxygen-sensitive drug without exposing the remaining unit dosages to oxygen is described herein. Each unit dose is individually encapsulated in the pharmaceutical packaging construction such that when one unit dose is dispensed the other unit doses remain encapsulated. An oxygen-absorber is also incorporated into the construction such that the oxygen absorber has sufficient contact with the air surrounding the oxygen-sensitive drug to remove at least a portion of the oxygen in the air to reduce or eliminate undesirable oxidative degradation of the drug in its encapsulated environment.
    Type: Application
    Filed: March 15, 2002
    Publication date: September 19, 2002
    Inventor: Kenneth C. Waterman
  • Publication number: 20020132352
    Abstract: In order to prevent a catalyst for an internal combustion engine from decreasing efficiency by deterioration after long time use of the catalyst, the decreased efficiency of the catalyst is determined, and the internal engine is controlled based on results of the determination so as to maintain high efficiency of the catalyst. The catalyst is installed in an exhaust pipe of the engine. Sensors for detecting conditions of exhaust gas both at upstream side and downstream side of the catalyst are provided, respectively. As for the sensor, for example, an oxygen sensor of which output varies stepwise at &lgr;=1, or a sensor of which output varies in proportion to air-fuel ratio can be used. Detected values of the sensors are taken into a control unit, eliminating efficiency and deteriorating degree of the catalyst are estimated by comparison of the detected values, and the engine is controlled so that the eliminating efficiency becomes maximum.
    Type: Application
    Filed: May 23, 2002
    Publication date: September 19, 2002
    Applicant: Hitachi, Ltd.
    Inventors: Minoru Ohsuga, Mamoru Fujieda, Nobuo Kurihara
  • Patent number: 6436347
    Abstract: A fast-response colorimetric carbon dioxide indicator device which is substantially insensitive to humidity and comprises a chemically inert substrate and an indicator composition supported by the substrate and responsive to exposure to carbon dioxide in expired respiratory air to undergo a color changing reaction. The indicator composition includes a pH sensitive dye and a basic substance having the general formula in which X is a nitrogen or phosphorus atom, each of R1, R2, R3 and R4 is an alkyl, Y− is an anion selected from the group consisting of hydroxide, fluoride, chloride, bromide, iodide, carbonate, and tetrafluoroborate, at least one of the alkyls R1, R2, R3 and R4 having at least 13 carbon atoms and at least one of the other alkyls having from 6 to 8 carbon atoms, the remaining alkyls, if any, having from 1 to 12 carbon atoms.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: August 20, 2002
    Assignee: Mincor AB
    Inventor: Andras Cedeon
  • Patent number: 6432718
    Abstract: In order to quickly and economically evaluate cleanliness of a metal with high representativity when quantities, compositions, etc., of non-metallic inclusion particles existing in a metal and resulting in product defects are evaluated by a sample collected during the production process of the metal, the present invention provides an evaluation method involving the steps of levitation-melting a metal piece for a predetermined time by cold crucible levitation-melting means, discharging non-metallic inclusion particles contained in the metal piece to the surface of a molten metal, and directly analyzing a curved and non-smooth sample surface after solidification by dissolving the surface and extracting and filtering the inclusions to measure or analyze the quantities of elements constituting the non-metallic inclusion particles and to determine quantity of the non-metallic inclusions.
    Type: Grant
    Filed: September 22, 1999
    Date of Patent: August 13, 2002
    Assignee: Nippon Steel Corporation
    Inventors: Kazushige Umezawa, Tokio Suzuki, Koichi Chiba, Ryuji Uemori, Takehiko Toh, Hiroyuki Kondo, Katsuhiro Fuchigami, Eiichi Takeuchi, Masamitsu Wakoh, Akihiro Ono
  • Patent number: 6429021
    Abstract: The present invention provides an assay for detecting the presence of an array or a profile of antioxidant activity in any sources or products. In particular, the invention provides a method in which a sample is extracted with a polar, a non-polar and a semi-polar solvent to obtain three extracts; the extracts are chromatographed to get a chemical profile; and the profile is analyzed to determine the presence of antioxidants by directly reacting to a free-radical.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: August 6, 2002
    Assignee: Amway Corporation
    Inventors: Yong Qian, Richard E. A. Leitz, David W. Krempin
  • Patent number: 6416737
    Abstract: The present invention is a method and composition to increase bone strength in a manner that decreases fracture incidence, which may or may not include increasing bone mineral density (“BMD”). The invention includes administering an effective amount of a bisphosphonate to a host in need thereof to increase bone strength, which inhibits the apoptosis of osteoblasts and osteocytes, without a significant effect on osteoclasts. In one embodiment, the bisphosphonate is not 1-amino-3-(N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid or its pharmaceutically acceptable salt. An increase in osteoblast life span can lead to an increase in bone mass, i.e., an anabolic effect. Preservation of osteocyte life span can increase bone strength, which may be disproportional to the increase in bone mass.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: July 9, 2002
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Stavros C. Manolagas, Teresita Bellido
  • Patent number: 6399387
    Abstract: The present invention relates to new color compositions which are especially suitable to be used in oxygen indicators. The compositions comprise iron(II), an agent containing pyrogallol entities and an organic acid.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: June 4, 2002
    Assignee: Pharmacia AB
    Inventors: Åke Stenholm, Lars Karlsson, Anders Löfgren, Bo Nyström, Otto Skolling
  • Patent number: 6391646
    Abstract: An electron paramagnetic resonance spectroscopic method for quantifying molecular oxygen and its isotopes in a sample and an electron paramagnetic resonance spectrometric cell for use in this method are provided.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: May 21, 2002
    Inventor: Sergi V. Khangulov
  • Patent number: 6387706
    Abstract: A method and apparatus for measuring vehicle exhaust emission includes sampling vehicle exhaust and a dilute mixture of vehicle exhaust and ambient air. A first analyzer measures concentrations of gas components of undiluted vehicle exhaust. A second analyzer measures concentration or temperature of at least one exhaust gas component present in the dilute mixture gas component. Flow rate of the dilute mixture, the concentration and/or temperature of the at least one dilute mixture gas component and undiluted gas concentration are analyzed by a microprocessor to produce mass emissions of the vehicle exhaust gas components.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: May 14, 2002
    Assignee: Sensors, Inc.
    Inventor: Gideon Eden
  • Patent number: 6368867
    Abstract: The present invention provides an ozone processing monitor and a method of using the same in ozone processing to determine whether sufficient ozone treatment has occurred on a production part needing ozone treatment. The ozone processing monitor of the present invention comprises an ozone sensitive material which is capable of thinning, bleaching, forming an oxide layer or undergoing any other physical or chemical change upon exposure to ozone, wherein said physical or chemical change produces a visible color change of said ozone sensitive material which can be monitored during or following ozone processing. The color change of the ozone sensitive material can be compared to standards to determine if too little, too much or appropriate ozone treatment has occurred.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: April 9, 2002
    Assignee: International Business Machines Corporation
    Inventors: Margaret Lecko Gibson, John James Lajza, Jr., Harold George Linde
  • Patent number: 6329208
    Abstract: Simple equations that relate glucose, glutamate, glucuronate, and phenylacetylglutamine 13C NMR multiplet areas to gluconeogenesis and pyruvate recycling during metabolism of [1,2,3-13C3]propionate are presented. This indicates that a direct measure of gluconeogenesis, pyruvate recycling, and anaplerosis may be obtained from a single 13C NMR spectrum of suitably prepared blood or urine samples collected after oral administration of enriched propionate, acetaminophen, and phenylacetate.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: December 11, 2001
    Assignee: Board of Regents, The University of Texas System
    Inventors: John G. Jones, A. Dean Sherry, F. M. H. Jeffrey, G. Larry Cottam, Craig. R. Malloy
  • Patent number: 6323038
    Abstract: In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders, and provides a diagnostic reagent for complications associated with diabetes or renal failure, containing the above compound as a main component.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: November 27, 2001
    Assignee: Asai Germanium Research Institute Co., Ltd.
    Inventors: Tomoko Oya, Hiroyuki Kobayashi, Mitsuo Akiba, Norihiro Kakimoto, Yasujiro Morimitsu, Toshihiko Osawa
  • Patent number: 6316269
    Abstract: The present invention provides screening methods for identifying compounds which induce tardive dyskinesia (TD) when administered to an animal. In particular, the methods involve assaying for intermediates and end products of reactions associated with candidate compound mediated reduction of reducible substrates. Also provided are high-throughput screening methods for determining whether compounds induce TD when administered to an animal. Further, provided are methods for treating psychoses comprising testing antipsychotic drugs to identify those which will not induce TD when administered to an animal and administering one or more such drugs to a patient in need thereof.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: November 13, 2001
    Assignee: The General Hospital Corporation
    Inventors: Guochuan Tsai, Xudong Huang, Ashley I. Bush
  • Patent number: 6306661
    Abstract: The oxygen concentration of a sample is determined utilizing a water-soluble metal ligand complex which is brought into interactive proximity with the sample to form a mixture. The mixture is irradiated with electromagnetic light energy so as to cause emission of light indicative of oxygen. The emitted light is measured, and the measurement utilized so as to determine oxygen concentration of the sample.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: October 23, 2001
    Inventors: Joseph R. Lakowicz, Felix Castellano
  • Patent number: 6284545
    Abstract: A filter for reducing the cross-sensitivity of a chlorine dioxide detector to hydrogen sulfide. The filter includes a high surface area substrate impregnated with a silver (I) salt or copper (II) salt which is effective to remove hydrogen sulfide from a gas stream without producing undesirable compounds which might be detected by the sensor. The preferred compounds are copper chloride (CuCl2), copper bromide (CuBr2), silver acetate (AgO2CCH3), silver bromate (AgBrO3), silver bromide (AgBr), silver carbonate (Ag2CO3), silver chloride (AgCl), silver chromate (Ag2CrO4), silver cyanide (AgCN), silver iodate (AgIO3), silver oxide (Ag2O), silver perchlorate (AgClO4), silver permanganate (AgMnO4), silver sulfate (Ag2SO4), silver hexafluorophosphate (AgPF6), silver fluoride (AgF), silver tetrafluoroborate (AgBF4), silver iodide (AgI) and silver trifluoromethane sulfonate (AgO3SCF3).
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: September 4, 2001
    Assignee: Industrial Scientific Corporation
    Inventors: P. Richard Warburton, Ronald Scott Sawtelle
  • Patent number: 6258606
    Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, time-shared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: July 10, 2001
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 6254829
    Abstract: There is disclosed an optical sensor including a matrix containing a luminescence indicator whose luminescence may be quenched by oxygen. The optical sensor contains at least one agent capable of deactivating singlet oxygen and has an enhanced stability relative to oxygen.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: July 3, 2001
    Assignee: AVL Medical Instruments
    Inventors: Paul Hartmann, Marco Jean Pierre Leiner
  • Patent number: 6207461
    Abstract: Compounds of formula (I) wherein Me is Pd(II) or Pt(II); R is H or C1-C18 alkyl, or is C3-C8 cycloalkyl, phenyl, pyridyl or phenyl-C1-C4 alkylene, each of which is unsubstituted or substituted by C1-C18 alkyl, C1-C18 alkoxy, R3—O—C(O)—, halogen, —CN or by —NO2; R1 and R2 are each independently of the other H, C1-C12 alkyl or C1-C12 alkoxy or R1 and R2 together are —OCH2O—, —OCH2CH2O—, or —CH═CH—CH═CH—, and R3 is C1-C18 alkyl, C3-C18 cycloalkyl, phenyl, benzyl, C1-C12 alkylphenyl or C1-C12 alkylbenzyl. Compounds of formula (I) are valuable luminophores and/or intermediates for the preparation of palladium (II) or platinum (II) benzoporphyrins, which are likewise luminophores.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: March 27, 2001
    Assignee: Novartis AG
    Inventors: Marcus Baumann, Adrian Waldner
  • Patent number: 6180412
    Abstract: An improved test is described for chlorine in pool and spa water where potassium monopersulfate is used as an oxidizing agent and DPD is used as an indicator. N,N-bis(hydroxyethyl)-2-aminoethane sulfonic acid or bicine is used to mask or eliminate the potassium monopersulfate so that it does not interfere with the DPD indicator. The test is very reliable and accurate.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 30, 2001
    Assignee: Hach Company
    Inventor: Dan J. Kroll
  • Patent number: 6171867
    Abstract: The invention relates to a sensor comprising a piezoelectric crystal with a polyarylene thioether-containing coating, the coating containing at least one polyarylene system having repeating units of the formula I, —[(Ar1)n—X]m—[(Ar2)i—Y]j—[(Ar3)k—Z]l—[(Ar4)o—W]p—  (I) which contain at least one thioether group, in which Ar1, Ar2, Ar3 and Ar4 are identical or different aryl systems having from 6 to 18 carbon atoms, W, X, Y and Z are identical or different linking groups, selected from the group comprising —SO2—, —S—, —SO—, —O—, —CO—, —CO2—, alkylene or alkylidene having from 1 to 6 carbon atoms and —NR1—, where R1 is an alkyl or alkylide group having from 1 to 6 carbon atoms and at least one linking group must be —S—, n, m, i, j, k, l, o, p are, equal or different, integers zero, 1, 2, 3 or 4, their sum havin
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: January 9, 2001
    Assignee: Ticona GmbH
    Inventors: Gernot Feucht, Andreas Schleicher, Georg Frank
  • Patent number: 6146896
    Abstract: A method and apparatus for determining nitrification effectiveness of activated sludge in an aqueous solution, includes supplying equivalent quantities of an activated sludge, an aqueous solution, and a gas containing oxygen to each of first and second reaction vessels; simultaneously delivering a nitrification inhibitor to only the second reaction vessel; performing a bacterial respiration reaction in the vessels for either a preselected period of time or continuously in which case the materials are supplied per unit of time so that the bacterial respiration reaction in the first reaction vessel, where oxygen consumption as a result of total bacterial respiration occurs and includes oxygen consumption as a result of endogenous respiration, oxygen consumption as a result of nitrification, and oxygen consumption as a result of degradation of carbon compounds, may be compared with the respiration reaction in the second reaction vessel where oxygen consumption includes oxygen consumption as a result of endogenou
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: November 14, 2000
    Assignee: LAR Analytik und Umweltmesstechnik GmbH
    Inventor: Ulrich Pilz
  • Patent number: 6143571
    Abstract: The method for analyzing a metal for oxygen, using inert gas carrying fusion/infrared absorption analysis, having the steps of: placing a metal analyte in a graphite crucible; heat-melting the metal analyte; extracting a gas from the melt bath; and analyzing the gas to determine the total oxygen content of the metal in the form of a plurality of separated waves, wherein the metal analyte is heated at a temperature rise rate of not more than 20.degree. C./sec in a period from a starting point A of a first wave to a peak point B of the first wave, held at a constant temperature in a period from the peak point B of the first wave to an end point C of the first wave, and, after the completion of the appearance of the first wave, is heated to melt the metal analyte for further analysis.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: November 7, 2000
    Assignee: Sanyo Special Steel Co., Ltd.
    Inventors: Yoshio Nuri, Tomoko Ise, Yoshiyuki Kato
  • Patent number: 6117686
    Abstract: The present invention provides a method by which harmful trace gases in a gaseous mixture containing as such harmful halogen gases, halogenated hydrogen gases, acid gases, oxidizing gases, basic gases, organic acid gases, especially halogen gases or halogenated hydrogen gases, are detected by using tetraphenylporphyrin (TPP) and quantitated from a calibration curve constructed therefrom, where the range of detectable concentration is made adjustable so that harmful gas can be detected and quantitated over a broad range of concentration. Furthermore, this invention also provides a method for extending the accessible range of gas concentration by adjusting the sensitivity of the detector material via control of tetraphenylporphyrin concentration in matrix polymer of the detector material, by controlling the gas concentration range via measurement at a specific wavelength(s), and by the use of a plurality of detector materials with pre-set assay sensitivity.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: September 12, 2000
    Assignee: Ebara Corporation
    Inventors: Kazunari Tanaka, Chiaki Igarashi, Yoshihiko Sadaoka
  • Patent number: 6087181
    Abstract: The present invention discloses a method for improving the speed and sensitivity of optical spectroscopic techniques for remote detection of trace chemical species in a carrier gas. The disclosed method can be applied to any optical spectroscopic detection technique whose sensitivity decreases as the total pressure of the sample decreases. The method employs an inert and non-absorbing buffer gas to supplement the pressure exerted by the carrier gas. This ensures that the total pressure of the sample, and hence sensitivity of the detection technique, remains high. The method is especially useful when measuring concentration of chemical species produced at small rates, and therefore should prove useful for rapid serial screening of combinatorial libraries of compounds.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: July 11, 2000
    Assignee: Symyx Technologies
    Inventor: Pejun Cong
  • Patent number: 6063637
    Abstract: Sensors (20, 50, 70) for use in detecting the presence of sugars and other analytes (target molecules). The sensor is composed of a metal complex that binds to the target molecule and releases a proton or includes an exchangable ligand which is exchanged for the target molecule during the binding interaction between the metal complex and the target molecule. The result of the binding interaction is the release of a proton, hydroxide ion or ligand species generated during the ligand exchange. Measurement of the release of proton, hydroxide ion or other ligand species from the sensor (20, 50, 70) provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures (10, 12) to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton or hydroxide release are disclosed, as are detection systems in which Cl.sup.- release is used.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: May 16, 2000
    Assignee: California Institute of Technology
    Inventors: Frances H. Arnold, Zhibin Guan, Chao-Tsen Chen, Guohua Chen
  • Patent number: 6046054
    Abstract: The selectivity of response of resistive gas sensors to specific gases or vapors is improved by the selection of specified gas-sensitive materials which are not previously known for the applications described, which include detection of hydrocarbons in the presence of CO, H.sub.2 S, SO.sub.2, chlorine, NO.sub.2, CO.sub.2 (especially in low concentrations), CFC's, ammonia, free oxygen by determination of partial pressures, and numerous organic gases and vapors.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: April 4, 2000
    Assignee: Capteur Sensors & Analysers, Ltd.
    Inventors: Peter McGeehin, Patrick Timothy Moseley, David Edward Williams, Geoffrey Stephen Henshaw, Darryl Hirst Dawson, Laura Jane Gellman
  • Patent number: 5993742
    Abstract: A device for the investigation of liquids, in particular of waste water, includes at least one reaction chamber for receiving the liquid to be investigated as well as liquids for analysis from storage containers. The reaction chamber is disposed in a housing while the storage containers are accommodated within the housing or are set up outside. The housing may be positioned in a freely floating manner within the liquid to be investigated or may be set up outside.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: November 30, 1999
    Assignee: ABB Patent GmbH
    Inventors: Dieter Binz, Albrecht Vogel, Brith Claesson, Hubert Braendle, Sean Keeping
  • Patent number: 5985674
    Abstract: In order to quickly and economically evaluate cleanliness of a metal with high representativity when quantities, compositions, etc., of non-metallic inclusion particles existing in a metal and resulting in product defects are evaluated by a sample collected during the production process of the metal, the present invention provides an evaluation method involving the steps of levitation-melting a metal piece for a predetermined time by cold crucible levitation-melting means, discharging non-metallic inclusion particles contained in the metal piece to the surface of a molten metal, and directly analyzing a curved and non-smooth sample surface after solidification by a fluorescent X-ray analysis method using an energy dispersion type spectroscope, or by other chemical or physical measurements, to measure or analyze the quantities of elements constituting the non-metallic inclusion particles and to determine quantity of the non-metallic inclusions.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: November 16, 1999
    Assignee: Nippon Steel Corporation
    Inventors: Kazushige Umezawa, Tokio Suzuki, Koichi Chiba, Ryuji Uemori, Takehiko Toh, Hiroyuki Kondo, Katsuhiro Fuchigami, Eiichi Takeuchi, Masamitsu Wakoh, Akihiro Ono
  • Patent number: 5972296
    Abstract: Oxygen sensor for measuring resistance as a function of oxygen partial pressure, made of alkaline-earth-doped perovskitic lanthanum ferrites with the general formulaLa.sub.1-x Me.sub.x FeO.sub.3-.delta.where Me is one of alkaline earth metals, Mg, Ca, Sr, and Ba, x is a degree of doping of the lanthanum ferrites. The oxygen sensor oxygen deficit of anion is 6=0 to 0.25, and the degree of doping of the lanthanum ferrites is x=0.1 to 0.3 and is selected to provide a temperature independent resistance property to the oxygen sensor in a lean range.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: October 26, 1999
    Assignee: Heraeus Electro-Nite International, N.V.
    Inventors: Karl-Heinz Hardtl, Ulrich Schonauer, Andreas Krug
  • Patent number: 5965452
    Abstract: An improved biologic electrode array and methods for manufacturing and using the same. In one aspect, a matrix of electrodes each coupled to a respective sample-and-hold circuit is provided. The electrodes and sample-and-hold circuits are integral and form an array within a single semiconductor chip, such that each sample-and-hold circuit may be loaded with a predefined voltage provided by a single, timeshared digital-to-analog converter (DAC). Further, all of the sample-and-hold circuits may be accessed through a multiplexer which may be scanned through some or all of the electrode locations. Each sample-and-hold circuit may comprise a capacitor and one or more transistor switches, the switch(es), when closed, providing electrical communication between the capacitor and a source line formed in the matrix.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: October 12, 1999
    Assignee: Nanogen, Inc.
    Inventor: Gregory T. A. Kovacs
  • Patent number: 5958785
    Abstract: Chronic or long-term alcohol consumption is detected and diagnosed by determining the levels of an alcohol-specific ethanol glycoconjugate biomarker, identified as ethyl .beta.-glucuronide, in body fluids (e.g. urine) of subjects by calorimetric reaction using qualitative and quantitative assay methods. Ethyl glucuronide has been newly observed and detected as a direct indicator of chronic alcohol consumption, and can be isolated and purified. Economical and reproducible assay methods, such as a chromatographic spot assay, ascending or thin layer chromatography assay, and high pressure liquid chromatography assay provide reliable, objective, and sensitive methods for detecting and monitoring a chronic alcoholic condition. Both the presence of the alcohol-specific ethyl glucuronide and a substantial increase in its levels are diagnostic of chronic alcoholism.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: September 28, 1999
    Assignee: Research Foundation for Mental Hygiene
    Inventors: Raju K. Pullarkat, Premilia S. Pullarkat, Simhachalam Raguthu
  • Patent number: 5952237
    Abstract: The present invention provides a method by which harmful trace gases in a gaseous mixture containing as such harmful halogen gases, halogenated hydrogen gases, acid gases, oxidizing gases, basic gases, organic acid gases, especially halogen gases or halogenated hydrogen gases, are detected by using tetraphenylporphyrin (TPP) and quantitated from a calibration curve constructed therefrom, where the range of detectable concentration is made adjustable so that harmful gas can be detected and quantitated over a broad range of concentration. Furthermore, this invention also provides a method for extending the accessible range of gas concentration by adjusting the sensitivity of the detector material via control of tetraphenylporphyrin concentration in matrix polymer of the detector material, by controlling the gas concentration range via measurement at a specific wavelength(s), and by the use of a plurality of detector materials with pre-set assay sensitivity.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: September 14, 1999
    Assignee: Ebara Corporation
    Inventors: Kazunari Tanaka, Chiaki Igarashi, Yoshihiko Sadaoka
  • Patent number: 5952235
    Abstract: The present invention relates to methods for detecting teratogen exposure in neonates. In particular, the present invention is directed to the detection of prenatal (i.e., in utero) exposure to ethanol. In accordance with the present invention, fatty acid ethyl esters, produced as the by-products of non-oxidative ethanol metabolism are detected in samples such as meconium and cord blood.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: September 14, 1999
    Assignee: Case Western Reserve University
    Inventor: Cynthia Bearer
  • Patent number: 5919710
    Abstract: A method for the quantitative determination of dissolved oxygen in a liquid fuel includes the steps of doping a sample of the fuel with a preselected concentration of a probe material including a luminophor which exhibits luminescence of wavelength which is quenched by oxygen dissolved in the fuel, illuminating the fuel with light from a coherent light source, such as a laser, of a wavelength which induces the luminescence in the luminophor, and thereafter measuring the change with time of the luminescence from the luminophor in the fuel and determing from the change with time of the luminescence the concentration of oxygen in the fuel.
    Type: Grant
    Filed: July 16, 1997
    Date of Patent: July 6, 1999
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: James R. Gord, Steven W. Buckner, William L. Weaver, Keith D. Grinstead, Jr.
  • Patent number: 5908789
    Abstract: The invention relates to a method and apparatus for determining the concentration of at least carbon dioxide in a gas mixture on the basis of the absorption of infrared radiation (2), said apparatus comprising: a radiation source (1), the radiation emitted thereby being aligned to travel through a measuring cell (4) containing a gas mixture (6) to be analyzed; an optical band-pass filter (10), which is transmissive to a first wavelength band and positioned on the path of radiation emerging from the measuring cell or entering into the measuring cell through which the radiation passes; and a first detector (14), positioned in the radiating direction downstream of said first band-pass filter and used for detecting the radiation intensity falling thereon. Said optical band-pass filter (10) has a band-pass which lies within the wavelength range of 4.38 .mu.m-4.47 .mu.m for measuring the total concentration of carbon dioxide by means of the absorption spectrum of a molecule .sup.13 CO.sub.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: June 1, 1999
    Assignee: Instrumentarium Oy
    Inventor: Kurt Peter Weckstrom
  • Patent number: 5877027
    Abstract: An analytical method for the quantitative determination of the impurities in silicon dioxide by which trace amounts of hardly soluble impurities contained in silicon dioxide can be reliably decomposed and converted into a solution so that the contents of all of the impurities contained in silicon dioxide or, in particular, zirconium in a natural quartz powder can be accurately determined. Silicon dioxide is decomposed with hydrofluoric acid or an acid mixture of hydrofluoric acid and another inorganic acid to give a decomposition solution which is, as such or after admixture with another inorganic acid, subjected to evaporation to dryness and the residue is heated to cause fusion with addition of a salt or hydroxide of an alkali metal followed by dissolution of the salt or hydroxide of an alkali metal with pure water or with an aqueous solution of an inorganic acid to give an aqueous solution which is subjected to quantitative analysis of the impurities therein.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: March 2, 1999
    Assignee: Shin-Etsu Quartz Products Co., Ltd.
    Inventors: Katsuhiko Kemmochi, Kiyotaka Maekawa, Chuzaemon Tsuji, Manabu Saitou, Hiroyuki Miyazawa, Hiroyuki Watanabe
  • Patent number: 5869344
    Abstract: The invention comprises a novel sample introduction system which incorporates a venturi pump to convey a sample gas to an analytical instrument at atmospheric pressure. An APCI, ICP or MIP mass spectrometer is preferred as the analytical instrument. Using such an inlet with an APCI mass spectrometer, the real-time analysis of trace materials present in breath is facilitated, enabling, for example, the release of compounds responsible for aroma and taste to be analysed during eating and drinking. The invention can also be used for headspace analysis and for monitoring the release of fragrances from skin or clothing.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: February 9, 1999
    Assignee: Micromass UK Limited
    Inventors: Robert Steven Timothy Linforth, Andrew John Taylor
  • Patent number: 5843784
    Abstract: To permit detection of trace unstable reaction products to clarify the reaction process of oxygenation, this invenion provides a method of introducing positron nuclide .sup.15 O as an oxygen additive into the reaction system.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: December 1, 1998
    Assignee: Research Development Corporation of Japan
    Inventors: Yasuyoshi Watanabe, Bengt Langstrom
  • Patent number: 5834313
    Abstract: A sterilization system using a sterilization process monitoring device which is capable of indicating the efficacy of the sterilization process in an enclosed sterilization container while still maintaining the sealed state of the sterilization container. The process monitoring device comprises at least one biological indicator and/or at least one chemical indicator. Upon completion of the sterilization cycle, the process monitoring device can be advantageously removed from the system to determine chemical and/or biological efficacy of the sterilization process. The removal of the biological and/or chemical indicators does not disturb the sterilized state of the articles inside the sterilization container.
    Type: Grant
    Filed: September 19, 1997
    Date of Patent: November 10, 1998
    Assignee: Johnson & Johnson Medical, Inc.
    Inventor: Szu-Min Lin
  • Patent number: 5747349
    Abstract: The present invention provides a method and apparatus for rapid measurement of a fluid bulk analyte, requiring only microscale volumes. Several fluid bulk analytes can be measured simultaneously and, for biological samples, the cell content can also be measured simultaneously. The invention comprises reporter beads for chemical analysis of fluid bulk properties such as pH, oxygen saturation and ion content. Each reporter bead comprises a substrate bead having a plurality of at least one type of fluorescent reporter molecules immobilized thereon. The fluorescent properties of the reporter bead are sensitive to a corresponding analyte. Reporter beads are added to a fluid sample and the analyte concentration is determined by measuring fluorescence of individual beads, for example in a flow cytometer. Alternatively, reporter molecules which change absorbance as a function of analyte concentration can be employed.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: May 5, 1998
    Assignee: University of Washington
    Inventors: Ger van den Engh, Bernhard H. Weigl
  • Patent number: 5747346
    Abstract: Chronic or long-term alcohol consumption is detected and monitored by determining the level of a newly-observed, alcohol-specific carbohydrate in body fluids (e.g. urine) of subjects by calorimetric reaction using qualitative and quantitative assay methods. The alcohol-specific carbohydrate have been identified as a novel ethyl glucuronide. Ethyl glucuronide is observed and detected in direct response to alcohol consumption in body fluids, and can be isolated and purified. Simple, economical, and reproducible assay methods, such as a spot assay and an ascending or thin layer chromatography assay, provide reliable, objective, and sensitive methods for detecting and monitoring a chronic alcoholic condition. Both the presence of the alcohol-specific ethyl glucuronide and a substantial increase in its levels are indicative of chronic alcoholism.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: May 5, 1998
    Assignee: Research Foundation for Mental Hygiene, Inc.
    Inventors: Raju K. Pullarkat, Premila S. Pullarkat, Simhachalam Raguthu
  • Patent number: 5726063
    Abstract: A colorimetric assay of enaldehydes or of malonic dialdehyde as lipid peroxidation indices in an aqueous medium includinga) addition to the medium of a reagent of a compound of general formula I and their optional addition salts with organic or inorganic bases or with organic or inorganic acids. ##STR1## in which formula: A and C, which may be identical or different, each represent H, ##STR2## wherein A and C cannot simultaneously represent H, with:R.sup.1 =H; alkyl; aralkyl; aryl substituted on the aryl ring; alkyl sulfonate Y.sup.+ ; alkyl phosphonate, Y.sup.+ ; or alkyl carboxylate, Y.sup.+ ;R.sup.2 =H; --OR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; SO.sub.3.sup.31 Y.sup.+ ; --CN; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ;R.sup.3 =H; --OR.sup.4 ; --NR.sup.5 R.sup.6 ; --SR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; --SO.sub.3 --Y.sup.+ ; --CN; --COR.sup.5 ; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ;R.sup.4 =H; alkyl; aralkyl; or aryl substituted on the aryl ring;R.sup.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: March 10, 1998
    Assignee: Oxis Isle of Man, Limited
    Inventors: Dominique Gerard-Monnier, Irene Erdelmeier, Jean Chaudiere, Jean-Claude Yadan
  • Patent number: 5708957
    Abstract: An optical sensor is disclosed which uses a radioluminescent light source to supply the incident radiation for detecting a selected substance in a test medium. The radioluminescent source includes a beta emitting radio isotope which energizes a co-immobilized luminophore to release light in a given wavelength for a chemical sensor operation. The radioluminescent source is coupled with a sensing matrix for detecting and quantifying the analyte of interest. The sensing matrix produces a characteristic signal based on either absorbance or fluorescence which varies according to the concentration of the selected analyte in the sample. A photodetector measures the resulting optical signal from which the analyte concentration is determined.
    Type: Grant
    Filed: February 2, 1996
    Date of Patent: January 13, 1998
    Assignee: University of Iowa Research Foundation
    Inventors: Han Chuang, Mark A. Arnold
  • Patent number: 5702955
    Abstract: The present invention is a method for the detection of hydrogen peroxide in biological fluids or an aqueous solution which involves contacting the solution with an oxidation-reduction indicator and a transition metal complex. The transition metal complex is either a creatinine coordinated with iron or a guanidine coordinated with iron.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: December 30, 1997
    Assignee: Bayer Corporation
    Inventor: Michael Pugia
  • Patent number: 5693877
    Abstract: In order to prevent a catalyst for an internal combustion engine from experiencing decreased efficiency by deterioration after long time use of the catalyst, the decreased efficiency of the catalyst is determined, and the internal engine is controlled based on results of the determination so as to maintain high efficiency of the catalyst. The catalyst is installed in an exhaust pipe of the engine. Sensors for detecting conditions of exhaust gas both at a upstream side and a downstream side of the catalyst are provided, respectively. As for the sensor, for example, an oxygen sensor whose output varies stepwise at .lambda.=1, or a sensor whose output varies in proportion to air-fuel ratio can be used. Detected values of the sensors are taken into a control unit, catalyst efficiency and deteriorating degree of the catalyst are estimated by comparison of the detected values, and the engine is controlled so that the catalyst efficiency is maximized.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: December 2, 1997
    Assignee: Hitachi, Ltd.
    Inventors: Minoru Ohsuga, Mamoru Fujieda, Nobuo Kurihara
  • Patent number: 5677191
    Abstract: A series of organic test papers are described for the detection and identification of all types of organic compounds such as aldehydes, ketones, esters, acids, amines, isocyanates, anhydrides, amides, nitrides, aromatics, phenols, ethers, and other organic compounds, said test papers comprising an absorbent paper or microporous plastic impregnated with a reagent or reagents capable of reacting with a class of organic compounds. The method of using the test papers for the identification of organic compounds comprises making a presumptive identification of the class of the unknown sample using FTIR spectroscopy, and then placing this presumptively identified sample onto the paper to generate a new substance known as a derivative of the organic compound, which aids in the identification of the unknown organic compound.
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: October 14, 1997
    Assignee: Janos Technology Inc.
    Inventor: William L. Truett
  • Patent number: 5668015
    Abstract: A kit and method are provided for determining the suitability of the level of organic material in an aquarium. A test sample of water is removed from an aquarium into a test sample container. The pH of the test sample can be lowered and then a quantity of potassium permanganate is added and the test sample is permitted to sit. A control sample of distilled water mixed with an equal amount of potassium permanganate is also prepared in a second container. After a period of time passes, the color of the test sample is compared to the color of the control sample. If the test sample is significantly lighter, additional potassium permanganate is added to the test sample and this procedure is repeated until the test sample achieves the color of the control solution. The amount of potassium permanganate needed to turn the test sample to the color of the control sample is directly proportional to the amount of organic material in the tank.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: September 16, 1997
    Assignee: Wardley Corporation
    Inventor: Joseph E. Gargas
  • Patent number: 5627076
    Abstract: An apparatus and method is presented for the determination of water soluble glycols and polyglycols (polyalkoxylates). The apparatus and method are particularly suited for the on-site quantitation of glycols and polyglycols in aqueous drilling fluids.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: May 6, 1997
    Assignee: Baker Hughes Incorporated
    Inventors: Nyal S. Walker, Patrick L. Henderson
  • Patent number: 5601979
    Abstract: A functionalized, magnetic controlled pore glass support useful in solid phase DNA synthesis is described. The support acts as a universal solid phase for direct oligonucleotide synthesis. The oligonucleotide bound MPG is useful directly to isolate or purify oligonucleotides which possess a section of complementary sequences.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: February 11, 1997
    Assignee: CPG, Inc.
    Inventor: Yuan N. Wong