Including Sample Preparation Patents (Class 436/174)
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Patent number: 8945930Abstract: A device adapted to determine an analyte concentration of a fluid sample using a test sensor. The device comprises a display adapted to display information to a user. The device further comprises at least one user-interface mechanism adapted to allow the user to interact with the device. The device further comprises a body portion including at least one opening formed therein, the at least one opening being of sufficient size to receive the test sensor. The device further comprises a memory adapted to store a plurality of stored analyte concentrations. The device further comprises a processing feature adapted to inhibit the stored analyte concentrations from being displayed on the display.Type: GrantFiled: February 6, 2014Date of Patent: February 3, 2015Assignee: Bayer HealthCare LLCInventor: Kevin Chang
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Patent number: 8945941Abstract: Aspects of the present invention relate to a method for the preparation of samples for MALDI MS imaging. Certain embodiments relate to a method of matrix deposition for samples, wherein tissue sections are prepared via a synergistic combination of fixation with matrix. In certain embodiments, tissue is fixed with cold solvent, according to well-established histology protocols, and in the presence of matrix, allowing for high resolution spatial mapping of protein, lipid, sugar, and/or nucleic acid distribution. In certain embodiments, the present invention relates to fixation with matrix of whole organisms. In certain embodiments, animals are perfused with fixation and matrix mixtures, which allows for direct mass spectrometry analysis.Type: GrantFiled: May 24, 2007Date of Patent: February 3, 2015Assignees: Brandeis University, The Brigham and Women's Hospital, Inc.Inventors: Jeffrey N. Agar, Nathalie Y. R. Agar
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Patent number: 8946169Abstract: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.Type: GrantFiled: March 8, 2013Date of Patent: February 3, 2015Assignee: NantBioScience, Inc.Inventors: Vuong Trieu, Neil P. Desai, Patrick Soon-Shiong
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Patent number: 8945932Abstract: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample.Type: GrantFiled: July 6, 2005Date of Patent: February 3, 2015Assignee: PerkinElmer Health Sciences, Inc.Inventors: Wayne F. Patton, Alvydas Mikulskis, Eva Golenko
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Patent number: 8945472Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.Type: GrantFiled: December 18, 2008Date of Patent: February 3, 2015Assignee: Koninklijke Philips N.V.Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
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Patent number: 8940248Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.Type: GrantFiled: April 29, 2013Date of Patent: January 27, 2015Assignee: Eppendorf AGInventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
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Patent number: 8940547Abstract: Apparatus and methods are provided for evidence specimen collection having integral reagent holders to hold reagent vials and having drying agent or desiccant holding areas that permit the renewal of the desiccant and permit the introduction of variously size desiccant qualities to allow modulation of the specimen drying time to achieve early stabilization of specimens while holding the specimen in an isolated drying area during storage and shipment and for simultaneous collection of multiple evidence samples with simultaneous storage, drying, marking, evidence security and shipping provided and with the provision for simultaneous storage, drying, marking, evidence security and shipping provided for a control specimen.Type: GrantFiled: February 25, 2011Date of Patent: January 27, 2015Assignee: The Bode Technology Group, Inc.Inventor: Jangbir S. Sangha
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Patent number: 8936762Abstract: The present invention relates generally to the field of high content screening of particles, e.g., cells in a flow cytometric system. In particular, the present invention relates to devices, methods and systems to obtain line-scan images of particles, e.g., cells, of a plurality of different samples simultaneously, where the line-scan images can be used to identify cells based on at least one of a variety of phenotypic characteristics such as shape, asymmetry, and intracellular information for cell sorting and selection. In some embodiments, the line-scan images are obtained as the particles, e.g., cells, in a plurality of different samples flow through a plurality of microchannels, reducing the need and time for focusing of the image detection system. In some embodiments, the laser spot size has a small spatial resolution for rapid capturing of images of cells. In some embodiments, the laser spot size has a larger spatial resolution for imaging of larger particles or cells, e.g., rare cells in a sample.Type: GrantFiled: September 1, 2010Date of Patent: January 20, 2015Assignee: Trustees of Boston UniversityInventors: Daniel J. Ehrlich, Brian McKenna
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Patent number: 8936944Abstract: A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is performed by a management system in response to the contagious condition being present.Type: GrantFiled: November 22, 2011Date of Patent: January 20, 2015Assignee: The Boeing CompanyInventors: Leora Peltz, Shawn Hyunsoo Park
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Patent number: 8936914Abstract: The present invention provides methods of aiding in a renal cell carcinoma prognosis that include quantifying expressed carbonic anhydrase in samples derived from renal cell carcinoma patients. The methods also identify patients that are likely to respond positively to selected courses of treatment. The invention further provides related computer program products.Type: GrantFiled: April 15, 2003Date of Patent: January 20, 2015Assignee: The Regents of the University of CaliforniaInventors: Matthew H. T. Bui, David Seligson, Arie S. Belldegrun
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Patent number: 8933396Abstract: Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.Type: GrantFiled: July 7, 2011Date of Patent: January 13, 2015Assignee: Thermo Fisher Scientific GmbHInventors: Joel Louette, John Charles Rogers, Scott M. Peterman, Bruno Domon, Elodie Duriez
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Patent number: 8932864Abstract: Provided is a method and device for identifying glycated protein in a sample using a matrix including a boronic acid moiety that binds glycated proteins.Type: GrantFiled: March 18, 2013Date of Patent: January 13, 2015Assignee: Samsung Electronics Co., Ltd.Inventors: Sang-kyu Kim, Sung-ha Park, Kyung-mi Song, Soo-suk Lee, Youn-suk Choi
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Patent number: 8932876Abstract: The present invention provides a simple and inexpensive method for removing metal and other impurities in a radioisotope solution. The invention further includes the development of a new parent/daughter generator system for collecting the daughter isotope in a concentrated solution.Type: GrantFiled: May 11, 2009Date of Patent: January 13, 2015Assignee: The Curators of the University of MissouriInventors: Cathy Sue Cutler, Gary John Ehrhardt, Hendrik Petrus Engelbrecht, Delbert E. Day
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Publication number: 20150011011Abstract: A method for controlled movement of magnetic carriers in a sample volume for performing immunoassays under weightless or reduced-weight conditions, wherein the magnetic carriers are moved inside the sample volume by means of permanent magnets movably arranged relative to at least one spatial axis of the sample volume.Type: ApplicationFiled: February 15, 2013Publication date: January 8, 2015Applicant: ASTRIUM GMBHInventors: Peter Kern, Herbert Backes
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Patent number: 8925734Abstract: A filter vial and piston are provided where the vial has a cylindrical wall with a closed bottom and open top and with the hollow, tubular piston therein. The piston has a distal end covered by a cup having a proximal cup seal extending outward to engage the walls of the vial to form a fluid tight seal with the vial during use. The distal end of the piston has a piston flange extending outwardly and located adjacent a recess in the piston so the cup forms a snap fit over the piston flange and extends into the recess. The piston flange causes the cup to bulge sufficiently outward to form a fluid tight seal with the vial during use. A filter is placed in the bottom of the cup and abuts an inwardly extending lip on the cup. The filter is held against the lip by a piston support at the distal end of the piston. A cup support at a distal end of the cup also helps support the filter.Type: GrantFiled: January 28, 2013Date of Patent: January 6, 2015Assignee: Scientific Plastic Products, Inc.Inventors: Samuel A. Ellis, Kishan G. Hingorani
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Patent number: 8926902Abstract: An automatic apparatus is described, which is suitable for the withdrawal of portions of biological material from a parent test tube (1), mobile in a conveyor (6) of a test tube transport plant by means of transport devices (8) of single test tubes, to be loaded in one or more child test tubes (2) countermarked beforehand with suitable identification means and to be sent to different biological material analysis instruments interfaced to said transport plant.Type: GrantFiled: March 12, 2010Date of Patent: January 6, 2015Assignee: Inpeco Holding Ltd.Inventor: Gianandrea Pedrazzini
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Patent number: 8927296Abstract: The invention provides droplet actuators and droplet actuator techniques. Among other things, the droplet actuators and methods are useful for manipulating beads on a droplet actuator, such as conducting droplet operations using bead-containing droplets on a droplet actuator. For example, beads may be manipulated on a droplet actuator in the context of executing a sample preparation protocol and/or an assay protocol. An output of the methods of the invention may be beads prepared for execution of an assay protocol. Another output of the methods of the invention may be results of an assay protocol executed using beads.Type: GrantFiled: May 18, 2009Date of Patent: January 6, 2015Assignee: Advanced Liquid Logic, Inc.Inventors: Ramakrishna Sista, Vamsee Pamula, Arjun Sudarsan, Vijay Srinivasan, Prasanna Thwar
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Patent number: 8926903Abstract: To perform accurate measurement in the analysis of chemical components with low concentration, pretreatment such as concentration and purification of samples is essential. For high-throughput of pretreatment of biological samples, various random clinical testing is encountered, where analytes change from sample to sample. The pretreatment apparatus has a separating agent selectively separating a specific component by allowing a sample solution to flow therethrough. A holding section holds a plurality of housing sections, which house the separating agent therein, and has an endless track. A pressurizing section applies pressure to the housing section in a continuous and random-accessible manner; and an extraction solution receiver mechanism selectively receives an extracted solution from the separating agent housed in the housing section. A mass spectrometer is that can be connected to the pretreatment apparatus. Thus, a large number of specimens can be simultaneously processed.Type: GrantFiled: July 8, 2009Date of Patent: January 6, 2015Assignee: Hitachi High-Technologies CorporationInventors: Makoto Nogami, Katsuhiro Kanda, Izumi Waki
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Patent number: 8921119Abstract: A method of conducting microwave-assisted high pressure high temperature chemistry is disclosed. The method includes the steps of digesting a sample in a strong acid at a temperature of at least 200° C. in a pressure resistant vessel that includes a lid while exerting a defined force against the lid in order to maintain gases under pressure in the vessel; directing gas under excess pressure from the vessel into a circumferential passage defined by the vessel and its pressure resistant lid; and directing the gas from the circumferential passage outwardly from the lid while preventing gas from flowing outwardly over the edge of the vessel.Type: GrantFiled: October 1, 2010Date of Patent: December 30, 2014Assignee: CEM CorporationInventors: Wyatt Hargett, Jr., David Barclay
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Patent number: 8921118Abstract: Paper-based microfluidic systems and methods of making the same are described.Type: GrantFiled: March 27, 2009Date of Patent: December 30, 2014Assignee: President and Fellows of Harvard CollegeInventors: Adam C. Siegel, Scott T. Phillips, Michael D. Dickey, Dorota Rozkiewicz, Benjamin Wiley, George M. Whitesides, Andres W. Martinez
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Patent number: 8921117Abstract: A method for determining the amount of hydrocarbons in a composition including hydrocarbons and water is provided. The method includes adding a chemical agent to the composition in order to form an emulsion of water and hydrocarbons, taking a sample of the emulsion and dissolving this sample in a common solvent for water and hydrocarbons in order to form a solution, and measuring the amount of hydrocarbons in the solution. An installation suitable for implementing this method is also provided.Type: GrantFiled: January 3, 2012Date of Patent: December 30, 2014Assignee: Total S.A.Inventors: Maurice Bourrel, Jean-Michel Gras
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Patent number: 8920723Abstract: A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.Type: GrantFiled: November 16, 2007Date of Patent: December 30, 2014Assignee: Protochips, Inc.Inventors: John Damiano, Jr., Stephen E. Mick, David P. Nackashi
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Patent number: 8920749Abstract: A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.Type: GrantFiled: August 14, 2013Date of Patent: December 30, 2014Assignee: Konica Minolta Medical & Graphic, Inc.Inventors: Youichi Aoki, Akihisa Nakajima, Kusunoki Higashino, Yasuhiro Sando, Yoshikazu Kurihara
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Publication number: 20140377759Abstract: The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.Type: ApplicationFiled: May 15, 2014Publication date: December 25, 2014Applicant: CEPHEIDInventors: REUEL VAN ATTA, FRANCISCO JAVIER DIAS LOURENCO
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Patent number: 8916385Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.Type: GrantFiled: December 13, 2007Date of Patent: December 23, 2014Assignee: Quest Diagnostics Investments, Inc.Inventors: Mildred M. Goldman, Nigel J. Clarke, Richard E. Reitz
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Patent number: 8912008Abstract: An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a dispensing condition for each measurement item or each type of reagent, and controls the reagent dispensing mechanism on the basis of the dispensing condition.Type: GrantFiled: July 29, 2008Date of Patent: December 16, 2014Assignee: Kabushiki Kaisha ToshibaInventor: Takehiko Onuma
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Patent number: 8906303Abstract: A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.Type: GrantFiled: March 16, 2009Date of Patent: December 9, 2014Assignee: Clondiag GmbHInventors: Eugen Ermantraut, Thomas Kaiser, Jens Tuchscheerer, Vico Baier, Torsten Schulz, Anke Wöstemeyer
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Patent number: 8906690Abstract: A method for estimating characteristics of a formation including collecting a formation sample, preparing the sample, and analyzing the sample using FTIR comprising identifying the kerogen lineshape and intensity. The method includes using the lineshape to obtain kerogen maturity, using the maturity to obtain the kerogen spectrum, and using the kerogen spectrum to obtain the mineralogy and kerogen content.Type: GrantFiled: April 13, 2012Date of Patent: December 9, 2014Assignee: Schlumberger Technology CorporationInventor: Andrew E. Pomerantz
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Patent number: 8900515Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.Type: GrantFiled: November 25, 2011Date of Patent: December 2, 2014Assignee: Health & Life Co., Ltd.Inventor: Meng Yi Lin
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Patent number: 8900877Abstract: A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.Type: GrantFiled: April 30, 2012Date of Patent: December 2, 2014Assignee: Luminex CorporationInventors: Steve Jia Chang Yu, Jesus Ching, Phillip You Fai Lee, David Hsiang Hu
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Publication number: 20140342465Abstract: A new laboratory automated system comprising a plurality of work cells coupled to a conveyor and a method for processing sample tubes are disclosed, both of which enable a system to maintain the maximum overall throughput regardless of the number and throughput of the individual work cells and regardless of the frequency at which sample tubes are loaded into the system. This is achieved by a sample buffer module coupled to the conveyor, the sample buffer module being in common to the plurality of work cells, and by a sample workflow manager configured to dispatch sample tubes from the sample buffer module to the work cells via the conveyor with a frequency for each work cell, which is equal to the sample processing throughput of each respective work cell.Type: ApplicationFiled: May 7, 2014Publication date: November 20, 2014Applicant: Roche Diagnostics Operations, Inc.Inventors: Joerg Haechler, Florian Schindler, Georgios Spitadakis
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Publication number: 20140335627Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge.Type: ApplicationFiled: May 2, 2014Publication date: November 13, 2014Applicant: CepheidInventors: RONALD CHANG, Douglas B. Dority, Steven Montgomery
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Patent number: 8883079Abstract: A water-quality monitoring system for an aquatic environment that includes a monitoring unit and a chemical indicator wheel designed and configured to be submerged in the water being monitored. The chemical indicator wheel includes a holder that supports a number of chemical indicators selected for use in measuring levels of constituents of the water. When in use, the wheel is drivingly engaged with a monitoring/measuring unit that includes at least one reader for reading the chemical indicators. In some embodiments, each apparatus includes a plurality of immobilized-dye-based chemical indicators that undergo an optically detectable physical change as levels of one or more constituents of the water change. Also disclosed are a variety of features that can be used to provide the monitoring system with additional functionalities.Type: GrantFiled: December 13, 2012Date of Patent: November 11, 2014Assignee: Step Ahead Innovations, Inc.Inventor: James E. Clark
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Patent number: 8883515Abstract: A biopsy pipette with a filter attached in an internal compartment of a pipette designed to prevent lodging and possible loss of the tissue specimen for analysis. A biopsy test tube may be provided with a biopsy bag attached in the internal compartment of the test tube. Further, a biopsy cassette may be provided with an opening configured to receive a pipette. An automated and non-automated system and method of using the biopsy pipette, biopsy test tube, and biopsy cassette in the processing of biopsy specimen is also disclosed.Type: GrantFiled: February 27, 2011Date of Patent: November 11, 2014Assignee: Board of Trustees of the University of ArkansasInventors: Shree G. Sharma, Manisha Singh
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Patent number: 8877512Abstract: The present invention is directed to a droplet actuator and methods of making and using the droplet actuator including one or more substrates configured to form a droplet operations gap and including a physical or chemical feature that may be provided at a predetermined locus within or exposed to the droplet operations gap and configured to retain a bubble in position within the droplet operations gap.Type: GrantFiled: January 25, 2010Date of Patent: November 4, 2014Assignee: Advanced Liquid Logic, Inc.Inventors: Vijay Srinivasan, Michael G. Pollack, Arjun Sudarsan, Zhishan Hua
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Patent number: 8877143Abstract: A microfluidic system comprising a plurality of photochemical reaction stages, the microfluidic system comprising a computational processor, a plurality of electrically-controllable photochemical reaction stages, and a series of controllable interconnections for connecting the photochemical reaction stages. In an implementation, the computational processor controls the electrically-controllable photochemical and other chemical reaction stages together with controllable interconnections so as to implement multi-step chemical processes. The microfluidic system can be configured to selectively drive a plurality of photochemical reactions within a mixture of chemical compounds via controlled emission of light of a plurality of wavelengths. The microfluidic system can be configured to comprise various interconnections and combinations of parallel and series chemical reaction stages, and can include a multichannel microfluidic chemical transfer bus.Type: GrantFiled: May 26, 2014Date of Patent: November 4, 2014Inventor: Lester Ludwig
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Patent number: 8877142Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: June 20, 2007Date of Patent: November 4, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Publication number: 20140315325Abstract: An assembly and related methods are described for the preparation and processing of samples in molecular biology assays and nucleic acid amplification reactions. The assembly allows rapid and easy processing with reduced sample handling compared to known sample preparation apparatus and methods. The assembly comprises a reaction vessel, a sample matrix and a lid. The invention further provides an integrated punch to punch out discs of the sample matrix into the reaction vessel (without handling); thereby reducing the sample handling required to generate the final amplified nucleic acid product.Type: ApplicationFiled: November 16, 2012Publication date: October 23, 2014Applicant: Epistem LimitedInventor: Ben Cobb
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Publication number: 20140315256Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.Type: ApplicationFiled: November 15, 2012Publication date: October 23, 2014Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
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Patent number: 8865413Abstract: The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) and antibodies binds to PCAT. The present invention provides that PCAT is used as targets for screening agents that modulates the PCAT activities. Further, the present invention provides methods for treating diseases associated with pancreas.Type: GrantFiled: May 4, 2011Date of Patent: October 21, 2014Assignee: Celera CorporationInventors: Bruno Domon, Ian McCaffery, Vaibhav Narayan, Scott Patterson
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Patent number: 8865476Abstract: The present invention comprises methods and systems that use acoustic radiation pressure.Type: GrantFiled: September 26, 2008Date of Patent: October 21, 2014Assignee: Life Technologies CorporationInventors: Michael D. Ward, Carleton C. Stewart, Gregory Kaduchak
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Patent number: 8865472Abstract: An analyzing device mixes a sample liquid with a reagent by rotation of the analyzing device about a rotation center to generate a centrifugal force. A measurement cell is formed so as to extend in a direction along which the centrifugal force is applied, and a capillary area to which the sample liquid is sucked by a capillary force is formed on one of the side walls of the measurement cell, the side walls being arranged in a rotational direction. The capillary area extends from the outer periphery position to the inner periphery of the measurement cell, thereby reducing the size of the analyzing device. Further, the sample liquid in the measurement cell is sucked to the capillary area by slowing or stopping a rotation, and then the rotation is accelerated to return the sample liquid in the capillary area to the measurement cell.Type: GrantFiled: February 4, 2009Date of Patent: October 21, 2014Assignee: Panasonic Healthcare Co., Ltd.Inventors: Hiroshi Saiki, Kouzou Tagashira, Kenji Watanabe, Kenji Ishibashi, Takuji Miyata
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Patent number: 8852946Abstract: Disclosed herein is a method for identifying the compounds contributing to urine odor emitting from an air conditioner, a method for artificially reproducing the detected urine odor, and preparing a corresponding urine odor composition. Through the analysis method of the present invention, the compounds contributing to the urine odor emitted from an air conditioner may be identified and quantified. The detected urine odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced urine odor may provide meaningful data required for development of an apparatus and a method for removing specific odor.Type: GrantFiled: December 14, 2012Date of Patent: October 7, 2014Assignee: Hyundai Motor CompanyInventors: Tae Hee Lee, Ji Wan Kim, Seok Man Kim
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Patent number: 8852945Abstract: Disclosed herein is a method for identifying compounds contributing to a sour odor emitting from an air conditioner, a method for artificially reproducing the detected sour odor and preparing a corresponding sour odor composition. Through the analysis method of the present invention, the compounds contributing to the sour odor emitted from an air conditioner may be identified and quantified. The detected sour odor may be reproduced from a combination of the compounds identified by the analysis method of the present invention. The reproduced sour odor may provide meaningful data required for development of an apparatus and a method for removing specific odors.Type: GrantFiled: December 4, 2012Date of Patent: October 7, 2014Assignee: Hyundai Motor CompanyInventors: Tae Hee Lee, Ji Wan Kim
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Patent number: 8852952Abstract: The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed.Type: GrantFiled: May 4, 2009Date of Patent: October 7, 2014Assignee: Advanced Liquid Logic, Inc.Inventors: Michael G. Pollack, Prasanna Thwar, Vamsee K. Pamula, Allen Eckhardt, Alexander Shenderov, Dwayne Allen, Vijay Srinivasan
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Patent number: 8846410Abstract: The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay.Type: GrantFiled: November 15, 2013Date of Patent: September 30, 2014Assignee: Advanced Liquid Logic, Inc.Inventors: Michael G. Pollack, Vamsee K. Pamula, Ramakrishna Sista, Arjun Sudarsan
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Patent number: 8845981Abstract: A device for volumetric metering a liquid biologic sample is provided. The device includes an initial chamber, a second chamber, a third chamber, a first valve, a second valve and a third valve. The chambers are each configured so that liquid sample disposed in the respective chamber is subject to capillary forces. Each chamber has a volume, and the volume of the initial chamber is greater than the volume of either the second or the third chambers. The valves each have a burst pressure. The burst pressure of the first valve is greater than the third burst pressure. The first valve is in fluid communication with the second chamber. The second valve is disposed between, and is in fluid communication with, the initial chamber and the third chamber. The third valve is in fluid communication with the third chamber.Type: GrantFiled: December 28, 2012Date of Patent: September 30, 2014Assignee: Abbott Point of Care, Inc.Inventor: Manav Mehta
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Patent number: 8846414Abstract: The present invention provides for the detection of cardiac markers on a droplet actuator. An aspect provides a method of assaying a cardiac marker in a biological sample from a subject, the method including providing a droplet actuator, loading the biological sample and assay reagents on the droplet actuator, executing droplet operations to create sample droplets from the sample and reagent droplets from the reagents on the droplet actuator, and executing droplet operations using the sample droplets and reagent droplets to produce a detectable signal indicative of the quantity of the cardiac marker in the biological sample. Still other aspects are provided.Type: GrantFiled: September 29, 2009Date of Patent: September 30, 2014Assignees: Advanced Liquid Logic, Inc., Duke UniversityInventors: Ramakrishna Sista, Vamsee K. Pamula, Arjun Sudarsan, Vijay Srinivasan, Michael G. Pollack, Richard B. Fair, Allen E. Eckhardt
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Patent number: 8841104Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: April 21, 2011Date of Patent: September 23, 2014Assignee: NanoMR, Inc.Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Publication number: 20140273266Abstract: The present disclosure provides a reactor cell assembly that utilizes a novel design and that is wholly or partially manufactured from Aluminum, such that reactions involving Hydrogen, for example, including solid-gas reactions and thermal decomposition reactions, are not affected by any degree of Hydrogen outgassing. This reactor cell assembly can be utilized in a wide range of optical and laser spectroscopy applications, as well as optical microscopy applications, including high-temperature and high-pressure applications. The result is that the elucidation of the role of Hydrogen in the reactions studied can be achieved. Various window assemblies can be utilized, such that high temperatures and high pressures can be accommodated and the signals obtained can be optimized.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: BABCOCK & WILCOX TECHNICAL SERVICES Y-12, L.L.C.Inventor: BABCOCK & WILCOX TECHNICAL SERVICES Y-12, L.L.C.