Viscosity Or Degree Of Polymerization Changed (e.g., Degrading, Cross Linking, Etc.) Patents (Class 536/41)
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Patent number: 5169838Abstract: The present invention relates, by way of novel industrial products which are useful in therapy, to the benzopyranone-.beta.-D-thioxyloside compounds of the formula ##STR1## in which: one of the substituents R or R' is an oxygen atom double-bonded to the corresponding cyclic carbon atom and the other is a group R.sub.1,the symbol represents a double bond conjugated to the CO group provided by one of the substituents R or R',X is a sulfur atom or an oxygen atom,R.sub.1 and R.sub.2, which are identical or different, are each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a halogen atom, a trifluoromethyl group or a phenyl group, it being possible for R.sub.1 and R.sub.2, taken together, to form a 7,8,9,10-tetrahydrodibenzo[b,d]pyran-6-one group or a 1,2,3,4-tetrahydro-9H-xanthen-9-one group with the benzopyranone group to which they are bonded, andY is the hydrogen atom or an aliphatic acyl group.Type: GrantFiled: September 10, 1990Date of Patent: December 8, 1992Assignee: Fournier Industrie et SanteInventors: Soth Samreth, Veronique Barberousse, Patrice Renaut, Francois Bellamy, Jean Millet
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Patent number: 5166337Abstract: An alkyl glycoside having alkyl groups of 8 to 24 carbon atoms and an average polymerization degree of 1 to 10 is prepared in one stage by reacting a saccharide and at least one alcohol of 8 to 24 carbon atoms in a reaction medium containing a non-polar solvent in the presence of an emulsifier.Type: GrantFiled: February 27, 1991Date of Patent: November 24, 1992Assignee: Huels AktiengesellschaftInventor: Norbert Ripke
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Patent number: 5164374Abstract: A method for the treatment of arthritis or a related autoimmune disease that exhibits immune complexes in serum or synovial fluid is provided which comprises exposure of the serum or synovial fluid to an oligosaccharide containing a structural component that inhibits or disrupts the degree of occupancy of the Fc carbohydrate binding site on IgG, e.g., sialyllactose.Type: GrantFiled: December 17, 1990Date of Patent: November 17, 1992Assignee: Monsanto CompanyInventors: Thomas W. Rademacher, Raymond A. Dwek
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Patent number: 5162517Abstract: The sugar alcohols given in the title can be prepared in epimer-free form from the corresponding sugars by catalytic hydrogenation in aqueous solution using hydrogen, the hydrogenation being carried out continuously at 100-500 bar of H.sub.2 and 60.degree.-125.degree. C. on a fixed bed of carrier-free mouldings composed of pressed powders of the elements of the iron group of the periodic table. The mouldings have a compressive strength of above 50 N and an internal surface of 10-90 m.sup.2 /g.Type: GrantFiled: September 20, 1990Date of Patent: November 10, 1992Assignee: Bayer AktiengesellschaftInventor: Gerhard Darsow
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Patent number: 5149793Abstract: Exo-3',4'-O-benzylidene-3"-dimethylchartreusin (exo-BDMC) or its salts and 3"-demethylchartreusin (3"-DMC) or its salts are provided according to the present invention. Exo-BDMC and its salts are useful for antitumorous agents and antibacterial agents. 3"-DMC and its salts are useful as starting materials for producing exo-BDMC.Type: GrantFiled: January 29, 1990Date of Patent: September 22, 1992Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Nobutoshi Yamada, Hideo Sugi, Sadanori Mizukoshi, Kenji Kon, Taiji Katayama
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Patent number: 5145839Abstract: Naringin and naringenin are disclosed as pharmaceuticals that selectively inhibit the growth of cancer cells in the presence of normal cells. They are also effective against cancer cells that are resistant to chemotherapy or radiotherapy. It is shown that naringin and naringenin selectively contract DNA chains of tumor cells but not DNA chains of normal cells. The subject compounds also exhibit anti-viral activity. A novel method for the recovery of naringin and naringenin from natural vegetable sources is taught.Type: GrantFiled: June 9, 1989Date of Patent: September 8, 1992Inventor: Mirko Beljanski
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Patent number: 5144017Abstract: Novel steroid compounds which are glycoside derivatives of 14.beta.-hydroxypregnane and 17.alpha.-acetoxy-6.alpha.-methylpregnane are described. The compounds have increased receptor potency when compared to their aglycone and beneficial renal effects.Type: GrantFiled: January 9, 1990Date of Patent: September 1, 1992Assignee: University of ManitobaInventors: Frank S. LaBella, John F. Templeton
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Patent number: 5144020Abstract: Fibrous water-wet nitrocellulose containing 4.5 to 5.5% moisture sprayed with a solvent/cosolvent mixture converts to spheroid, densified nitrocellulose via bilateral agitation. A free-flowing dust-free product having a lower burn rate is produced which dissolves more rapidly for lacquer production. A preferred apparatus is an orbital shaker and a preferred solvent/cosolvent is isopropyl acetate/isopropyl alcohol.Type: GrantFiled: May 17, 1991Date of Patent: September 1, 1992Assignee: Aqualon CompanyInventor: Kwan F. Fung
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Patent number: 5142031Abstract: Disclosed herein is a method of labelling a sugar at its reducing end by using 1-(p-methoxyphenyl)-3-methyl-5-pyrazolone, thereby analyzing said sugar with high sensitivity, and to a kit to be used for sugar labelling by this method.Type: GrantFiled: October 11, 1991Date of Patent: August 25, 1992Assignee: Takara Shuzo Co., Ltd.Inventors: Yuan C. Lee, Susumu Honda, Kazuaki Kakehi
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Patent number: 5141925Abstract: The present invention provides a method for the prophylactic and/or therapeutic treatment of living animals susceptible to infection by at least one parasite able to cause Coccidiosis. The methodology utilizes the ability of each genus and species of infectious parasite as producing its own unique, biochemically distinct, specific lectin composition in vivo as part of the normal life cycle. The method of treatment administers a composition comprising at least one sugar to the living animal, this sugar comprising compound being able to bind selectively with the specific lectin composition of the parasite in vivo. Use of this method causes a loss of parasite infectivity and a subsequent excretion of the infectious parasite into the environment at large.Type: GrantFiled: April 23, 1990Date of Patent: August 25, 1992Assignee: Trustees of Tufts CollegeInventors: Joseph Alroy, Miercio E. A. Pereira
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Patent number: 5138044Abstract: Reaction schemes for carrying out a variety of chemical synthesis are disclosed. The reactions produce .alpha.-(X)-sialosides wherein X is O, S, N or another compatible electron donating atom or molecular moiety. The reaction schemes include a relatively small number of steps to provide a yield with a relatively small amount of undesired .beta.-configuration product. Compounds synthesized are encompassed by the following general structural formula I. ##STR1## wherein R, R' and R" are each independently H, CH.sub.3, acetyl, or a disaccharide which is preferably lactose.Type: GrantFiled: August 13, 1990Date of Patent: August 11, 1992Assignee: Glycomed, Inc.Inventor: Falguni Dasgupta
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Patent number: 5137723Abstract: .alpha.-Glycosyl-L-ascorbic acid exhibiting no direct reducing activity is formed in a solution containing L-ascorbic acid and an .alpha.-glucosyl saccharide when subjected to the action of a saccharide-transferring enzyme. .alpha.-Glycosyl-L-ascorbic acid is superiorly stable, and readily hydrolyzable in vivo to exhibit the activities inherent to L-ascorbic acid. Thus, .alpha.-glycosyl-L-ascorbic acid is favorably useful as a stabilizer, quality-improving agent, antioxidant, physiologically active agent and uv-absorbent in food pharmaceutical and cosmetic industries.Type: GrantFiled: March 30, 1990Date of Patent: August 11, 1992Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Itaru Yamamoto, Norio Muto, Toshio Miyake
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Patent number: 5136032Abstract: A phosphopolyol compound, such as pyrogens, is separated from a solution to be used in the pharmaceutical field by bringing the solution into contact with a porous adsorbent which has a pore size of 1 nm to 20 microns and comprises a base material and a functional chain group of an aliphatic amine having a chain length of 2 to 50, bonded to the base material.Type: GrantFiled: November 29, 1990Date of Patent: August 4, 1992Assignees: Daicel Chemical Industries, Ltd., Tanabe Seiyaku Co., Ltd.Inventors: Shinji Nagamatsu, Yoshikazu Tanaka, Thoru Shibata
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Patent number: 5136031Abstract: A process for the chlorination of sucrose or a derivative thereof, comprises reaction of the sucrose or derivative thereof with thionyl chloride and a nitrogen base at a ratio of about 1 molar equivalent (ME) of thionyl chloride and about 1 ME of base for every ME of free hydroxyl, in a non-reactive moderately polar solvent. The process is particularly suitable for the preparation of sucralose.Type: GrantFiled: July 9, 1990Date of Patent: August 4, 1992Assignee: Tate & Lyle Public Limited CompanyInventors: Riaz A. Khan, George H. Sankey, Philip J. Simpson, Nicholas M. Vernon
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Patent number: 5134230Abstract: A disaccharide compound represented by formula (I): ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the specification and a salt thereof are disclosed. The compound exhibits excellent antitumor activity and low toxicity and is useful as an antitumor agent.Type: GrantFiled: January 18, 1991Date of Patent: July 28, 1992Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Tsuneo Kusama, Tsunehiko Soga, Tetsuo Shiba
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Patent number: 5132296Abstract: A channel protein having a Na.sup.+ /K.sup.+ selectivity of approximately 100 and capable of affecting Na.sup.+ membrane transport is disclosed. Amiloride derivatives, and amiloride gel materials incorporating such derivatives, useful in treating membrane transport, cellular volume and cellular pressure disorders and in isolating the channel protein are also disclosed. Use of the channel protein in diagnostic assays and screening assays is described.Type: GrantFiled: April 30, 1990Date of Patent: July 21, 1992Inventor: Bruce D. Cherksey
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Patent number: 5132413Abstract: A sugar chain of the following formula is disclosed. ##STR1## It can be prepared by separating glycoproteins from cell membrane components by using lectins which recognize the sugar chain, releasing the sugar chain structure from the glycoproteins, and purifying the released sugar chain. The sugar chain is useful for the diagnosis and treatment of cancer.Type: GrantFiled: September 25, 1990Date of Patent: July 21, 1992Assignee: Japan Immuno Research Laboratories Co., Ltd.Inventors: Akihiro Aizawa, Nobuo Shimoda, Masakazu Adachi, Katsunari Tezuka, Hideko Ishihara, Hiroyuki Hanzawa, Yoji Arata, Noriko Takahashi
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Patent number: 5132416Abstract: Compounds of the formula (I) ##STR1## wherein R.sup.1 represents a pyranosyl radical and R.sup.4, R.sup.2, and R.sup.3 are as specified herein, compositions containing the compounds, methods of using the compounds to selectively kill tumor cells, and a process for the preparation of the compounds.Type: GrantFiled: August 20, 1990Date of Patent: July 21, 1992Assignee: Bayer AktiengesellschaftInventors: Lutz F. Tietze, Roland Fischer, Matthias Beller
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Patent number: 5132294Type: GrantFiled: July 2, 1991Date of Patent: July 21, 1992Assignee: Kabushiki Kaisha Kobe Seiko ShoInventors: Akio Mimura, Keiichi Takebayashi, Yoshimasa Takahara, Toshihiko Osawa
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Patent number: 5130420Abstract: A process is described for the production of an alkyl glycoside which comprises distilling a higher alcohol in the presence of an alkaline substance, or washing a higher alcohol with an aqueous solution of an alkaline substance, and then reacting the higher alcohol with a sugar or a reaction product of a sugar and a lower alcohol. According to this process, an alkyl glycoside showing an excellent hue can be produced by repeatedly using unreacted alcohol recovered from the reaction mixture in the production of an alkyl glycoside.Type: GrantFiled: March 16, 1990Date of Patent: July 14, 1992Assignee: Kao CorporationInventors: Akira Yamamuro, Toyomi Koike, Hiroki Sawada, Akio Kimura
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Patent number: 5128458Abstract: 2'3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula ##STR1## where X=H, N.sub.3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases.The intermediate 1-O-acetyl-5-O-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides is also disclosed.Type: GrantFiled: January 9, 1991Date of Patent: July 7, 1992Assignee: Southern Research InstituteInventors: John A. Montgomery, John A. Secrist, III
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Patent number: 5128262Abstract: The microbial decontamination of soils contaminated with hydrocarbons, in particular with mineral oils, by microbial oxidation is improved by a process in which in addition to supplying the oxygen necessary for degradation, by aeration, soluble nutrients, water and soluble or dispersed biosurfactants as such or mixed with chemical surfactants are metered into the contaminated soils directly or into the removed contaminated soil layers, in one or more batches at time intervals, in an amount such that the formation of toxic intermediates which slow down or block microbial degradation in prevented, the accessibility of mineral oils and their products for the microorganisms is simultaneously increased and, as a result, accelerated, virtually complete mineralization by respiration to CO.sub.2 and H.sub.2 O is effected.Type: GrantFiled: September 30, 1988Date of Patent: July 7, 1992Assignee: Wintershell AGInventors: Walter Lindoerfer, Kai-Udo Sewe, Axel Oberbremer, Reinhard Mueller-Hurtig, Fritz Wagner
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Patent number: 5128462Abstract: Alkyl and hydroxyalkyl ethers of polygalactomannans are further modified with long chain haloalkanoic acids. The resulting derivatized polygalactomannans are useful as thickening agents in aqueous systems, particularly in combination with surfactants at acidic pH.Type: GrantFiled: July 1, 1991Date of Patent: July 7, 1992Assignee: Rhone-Poulenc Inc.Inventor: George M. Zody
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Patent number: 5126441Abstract: Bisglycosides IGly--O--CHR.sup.2 --(CH.sub.2).sub.p --(XR.sup.1).sub.n --(CH.sub.2).sub.q --(CHR.sup.3).sub.m --O--Gly IwhereX is C--R.sup.4 or N,R.sup.1 is C.sub.1 -C.sub.30 -alkyl, C.sub.2 -C.sub.30 -alkenyl, O--C.sub.1 -C.sub.30 -alkyl or O--C.sub.2 -C.sub.30 -alkenyl when X is C--R.sup.4, and is CO--C.sub.1 -C.sub.30 -alkyl or CO--C.sub.2 -C.sub.30 -alkenyl when X is N,R.sup.2 to R.sup.4 are each hydrogen, C.sub.1 -C.sub.30 -alkyl or C.sub.2 -C.sub.30 -alkenyl,n is from 1 to 3,m is 0 or 1,p and q are each from 0 to 2 andGly is a mono- or disaccharide composed of aldopentoses,aldohexoses and/or ketohexoses,are used as surfactants or emulsifiers in detergents, cleaning agents and toiletries.Type: GrantFiled: February 15, 1991Date of Patent: June 30, 1992Assignee: BASF AktiengesellschaftInventors: Gerhard Wolf, Richard R. Schmidt, Karin Jankowski, Andreas Terjung
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Patent number: 5126437Abstract: Compounds of the formula ##STR1## in which R.sup.1 represents saturated, unsaturated or anhydro desoxypentosyl, desoxyhexosyl or didesoxyhexosyl, where the OH functions of the sugar are optionally protected, andR.sup.2 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andR.sup.3 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andX represents halogens andR.sup.4 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms.Such compounds are useful as highly selective cytostatics in cancer therapy.Type: GrantFiled: June 7, 1989Date of Patent: June 30, 1992Assignee: Bayer AktiengesellschaftInventors: Lutz-F. Tietze, Manfred Neumann, Roland Fischer
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Patent number: 5126500Abstract: A process for preparing retinyl glycosides of the formula I ##STR1## where Z is a glycosidic residue, by glycosidation of a completely acylated carbohydrate or completely acylated glycosidic polymer of the formula IIZ (acylated)-Y (II)where Y is a leaving group customary for glycosidations in the 1-position of the glycoside, comprises the acylated glycoside being reacted with an aldehyde-protected 4-hydroxy-2-methyl-2-buten-1-al under the conditions customary for glycosidations, eliminating the aldehyde protective group from the resulting compound, subjecting the resulting aldehyde to a Wittig reaction with a .beta.-ionylideneethyltriphenylphosphonium salt and eliminating the acyl groups on the resulting retinyl glycoside in a conventional manner.The process according to the invention is particularly important for preparing retinyl glycosides of the formula Ia ##STR2## where R is --CH.sub.2 --OH, --COOH or --COOCH.sub.3. Intermediates of this process are also claimed.Type: GrantFiled: January 28, 1991Date of Patent: June 30, 1992Assignee: BASF AktiengesellschaftInventors: Ulrich von Deessen, Joachim Paust, Klaus Kaiser, Helmut Indest
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Patent number: 5122602Abstract: Chromogenic merocyanine enzyme substrate compounds of the general formula: ##STR1## where Y is an enzymatically-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid; A and B represent residues that complete 5- or 6-membered ring systems; R.sup.1 is substituted or unsubstituted alkyl; R.sup.2 and R.sup.3, independently, are hydrogen or lower alkyl; m, n, and p, which can be different, are integers from 0 through 3 provided that m+n+p must be at least 2; and X is an appropriate counterion (anion).Type: GrantFiled: February 13, 1989Date of Patent: June 16, 1992Assignee: Miles Inc.Inventors: Paul F. Corey, M. Teresa Yip
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Patent number: 5120835Abstract: Novel saccharide derivatives of protocatechualdehyde represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a benzoyl group, and R.sup.2 represents an alkyl group.The method for preparing thereof and the use of the compound as antiinflammatory agents.Type: GrantFiled: July 18, 1990Date of Patent: June 9, 1992Assignee: Kureha Chemical Industry Co., Ltd.Inventors: Kazuyoshi Inada, Sakuo Noda, Fumihiko Kimura
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Patent number: 5120839Abstract: The invention relates to amido-linked oligosaccharide alditols, i.e. oligosaccharide alditols with an amido linkage, having the general formula ##STR1## wherein: R.sub.1 =the alditol portion of a mono-, di- or oligosaccharide alditol, in which the alditol portion has 2 to 6 carbon atoms, andR.sub.2 =the alditol portion of a mono-, di- or oligosaccharide alditol, in which the alditol portion has 3 to 7 carbon atoms and is combined with the terminal or another carbon atom.They are manufactured by N-acylation of amino polyols derived from saccharides, with a sugar acid in the presence of methanol or in aprotic polar solvents.Type: GrantFiled: June 19, 1990Date of Patent: June 9, 1992Assignee: Suddeutsche Zucker-AktiengesellschaftInventors: Karola Hahn, Bernd Schneider
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Patent number: 5120719Abstract: A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.Type: GrantFiled: November 15, 1989Date of Patent: June 9, 1992Assignee: Eisai Co., Ltd.Inventors: Kiyoshi Iwamoto, Masahiro Kawahara, Sumio Watanabe, Yasuo Miyake, Fumio Sagami
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Patent number: 5118671Abstract: Complexes formed between aescin, cholesterol or .beta.-sitosterol and phospholipids are described. The molar ratio of phospholipids to aescin/.beta.-sitosterol or cholesterol is from 0.5 to 2. The phospholipids are selected from the group of soy or egg lecithins, phospholipids from bovine or swine brain or cutis, phosphatidylcholine, phospatidylserine, phosphatidylethanolamine in which the acyl groups may be the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids, for instance, pharmaceutical compositions and a method for producing an anti-inflammatory effect in an animal are also described.Type: GrantFiled: December 19, 1990Date of Patent: June 2, 1992Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Gianfranco Patri, Roberto Pozzi
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Patent number: 5116961Abstract: A 1',6,6'-trimethylacryloyl-2,3,3',4,4'-penta-O-methylsucrose compound is disclosed. This compound is prepared by treating 2,3,3',4,4'-penta-O-methylsucrose with methacryloyl chloride in the presence of triethylamine and tetrahydrofuran. This compound is used as a crosslinking agent in the preparation of polymers.Type: GrantFiled: May 10, 1991Date of Patent: May 26, 1992Assignee: Hawaiian Sugar Planters' AssociationInventor: Navzer Sachinvala
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Patent number: 5109127Abstract: A nonionic surface active agent comprising a fatty acid ester of a hexose sugar or an alkyl glycoside thereof, wherein the content of monoester is from 93 to 99.9% by weight, the content of diester is from 0.1 to 7% by weight and the content of tri- and higher polyesters is from 0 to 1% by weight in the fatty acid ester.Type: GrantFiled: November 5, 1990Date of Patent: April 28, 1992Assignee: Lion CorporationInventors: Shizuo Sekiguchi, Tomoko Yasumasu, Hiroshi Miyake, Yoshihisa Endo
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Patent number: 5109128Abstract: A process is presented for the continuous oxidation of alditols to aldoses accompanied by under 20 weight percent of aldonic and/or alduronic acids relative to the aldoses that are formed. The use of zerovalent platinum on a support such as theta-alumina and at superatmospheric oxygen partial pressures up to about 1,000 pounds per square inch is partially successful in affording good conversion of alditols with relatively low aldonic and/or alduronic acid formation.Type: GrantFiled: January 18, 1991Date of Patent: April 28, 1992Assignee: UOPInventors: Elaine F. Schumacher, Blaise J. Arena
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Patent number: 5106967Abstract: Disclosed are novel 5-C-hydroxymethylhexose compounds and their derivatives which exhibit sugar-like functionality when used in food compositions. The derivatives include stereoisomers, di-, tri-, and polysaccharides, alkyl glycosides, polyol, and alditol derivatives. Also disclosed are sugar substitute compositions and food compositions containing these compounds and their derivatives.Type: GrantFiled: May 28, 1991Date of Patent: April 21, 1992Assignee: The Procter & Gamble CompanyInventor: Adam W. Mazur
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Patent number: 5104797Abstract: Processes of the present invention provide economical methods for preparing derivatives 5-C-hydroxymethyl-D-aldohexose and their bicyclic anhydro tautomeric forms. The 5-C-hydroxymethylation process comprises an enzymic oxidation reaction followed by a condenation reaction with formaldehyde.Type: GrantFiled: April 17, 1989Date of Patent: April 14, 1992Assignee: The Procter & Gamble CompanyInventors: Adam W. Mazur, George D. Hiler, II, Gordon K. Stipp, Bernard W. Kluesener
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Patent number: 5104887Abstract: High potency carbonic anhydrase inhibitors derived from methazolamide.Type: GrantFiled: August 28, 1991Date of Patent: April 14, 1992Assignee: University of Iowa Research FoundationInventors: Ronald D. Schoenwald, Charles F. Barfknecht
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Patent number: 5104982Abstract: Axial anomeric sulfoxides generated via thiophenol Ferrier rearrangement of glucal and galactal derivatives are used to synthesize glycals of the gulal and allal series. An application of the method led to the synthesis of the esperamicin thiosugar.Type: GrantFiled: March 23, 1990Date of Patent: April 14, 1992Assignee: Yale UniversityInventors: Randall L. Halcomb, Samuel J. Danishefsky, Mark D. Wittman
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Patent number: 5101026Abstract: The present invention relates to ganglioside related compounds having, for example, the following formula: ##STR1## where R.sub.1 represents H or COCH.sub.3 (hereinafter abbreviated to "AC"); R.sub.2 represents H or CH.sub.3 ; and R.sub.3 represents --OH, ##STR2## These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.Type: GrantFiled: August 6, 1987Date of Patent: March 31, 1992Assignee: MECT CorporationInventors: Tomoya Ogawa, Mamoru Sugimoto, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Shigeki Nunomura
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Patent number: 5100913Abstract: The present invention relates, by way of novel industrial products, to the sulfonylphenyl-.beta.-D-thioxyloside compounds of the formula ##STR1## in which: X is a sulfur atom or an oxygen atom;R is a C.sub.1 -C.sub.4 alkyl group, a substituted amino group NR.sub.1 R.sub.2 (where R.sub.1 and R.sub.2, which are identical or different, are each a C.sub.1 -C.sub.4 alkyl group, it being possible for R.sub.1 and R.sub.2, taken together, to form a piperidinyl or morpholinyl group with the nitrogen atom to which they are bonded) or a phenyl group which is unsubstituted or substituted in the para position by a cyano group or by a halogen atom; andY is the hydrogen atom or an aliphatic acyl group.These compounds are useful in therapeutics, especially as venous antithrombotics.Type: GrantFiled: March 25, 1991Date of Patent: March 31, 1992Assignee: Fournier Industrie et SanteInventors: Soth Samreth, Patrice Renaut, Jerzy Bajgrowicz, Jean Millet
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Patent number: 5098828Abstract: The object of the invention consists of D-luciferin derivatives of General Formula (I) ##STR1## wherein R.sup.1 =OH, alkoxy, alkenyloxy, amino acid, NH.sub.2 or oligopeptide andR.sup.2 =H; H.sub.2 PO.sub.3 --; HSO.sub.3 --; alkyl or alkenyl, optionally substituted by phenyl; aryl; ##STR2## with R.sup.3 =alkyl or alkenyl, optionally substituted by phenyl; mono- or disaccharide or nucleotide.An object of the invention is further the use of said luciferin derivatives for the detection of ligands in the determination of biochemical substances, in particular in enzyme immuno assays, in blot processes and in nucleic acid hybridization. These ligands are attached to an enzyme (enzyme conjugate). In the process, for example an antigen, a hapten or an antibody is conjugated with an enzyme. The enzyme conjugate is capable of releasing luciferin from the luciferin derivative. The luciferin released is reacted with luciferase. The amount of light emitted in the process is determined.Type: GrantFiled: August 19, 1987Date of Patent: March 24, 1992Inventors: Reinhard Geiger, Werner Miska
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Patent number: 5095104Abstract: A glucofuranose derivative substituted at the 3,5,6- or 3,6-positions with a radical that provides an anionic charge at physiological pH values is disclosed, as are pharmaceutical compositions, and methods of making and using the same. The compounds are useful in treating inflammation, and particularly conditions that involve neutrophil influx; they are also useful in inhibiting peptic ulcer formation.Type: GrantFiled: August 3, 1990Date of Patent: March 10, 1992Inventor: Paul Gordon
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Patent number: 5095026Abstract: Prodrugs are prepared of the carbonic anhydrase inhibitors 2-benzothiazolesulfonamide, hydroxymethazolamide, and dichlorphenamide. The prodrugs link a water soluble compound to the pharmacologically active carbonic anhydrase inhibitor through an enzymatically or hydrolytically degradable bond.Type: GrantFiled: September 22, 1989Date of Patent: March 10, 1992Assignee: University of Iowa Research FoundationInventors: Ronald D. Schoenwald, Charles F. Barfknecht
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Patent number: 5093485Abstract: A polysaccharide-based composition, characterized by comprising or essentially consisting of:at least a first component a) excluding galactane constituted by a substituted .beta.-1,4-linked glycan which is dissolvable in water of a certain temperature and which has a molecular weight (Mw) of .gtoreq.5.multidot.10.sup.4 Daltons, preferably.gtoreq.10.sup.5 Daltons, particularly .gtoreq.10.sup.6 Daltons, andat least a second component b), also excluding galactans, constituted by a substituted .beta.-1,4-linked glycan which is more difficult to dissolve than said first component at said temperature, or is agar or a carrageenan;the use of the composiiton above as a:a) means for reducing friction,b) means for facilitating removal of undesired contamination from surfaces, such as graffiti, scrawl, soot etc.Type: GrantFiled: December 29, 1989Date of Patent: March 3, 1992Assignee: Polysaccharide Industries Aktiebolag PsiInventor: Sigfrid Svensson
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Patent number: 5093323Abstract: As a new compound is now provided N-acetylbenanomicin B which is useful as an antifungal agent and also as antiviral agent for inhibiting infection of human T-cell with HIV, namely a virus causative of acquired human immunodeficiency syndrome. N-acetylbenanomicin B may be prepared by acetylation of 4"-amino group of benanomicin B which is fermentatively produced by a new microorganism, MH193-16F4 strain of actinomycetes.Type: GrantFiled: December 29, 1989Date of Patent: March 3, 1992Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Shinichi Kondo, Shuichi Gomi, Hiroo Hoshino
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Patent number: 5091413Abstract: An antibiotic agent produced by the cultivation of Dictyochaeta simplex is described. The compound has broad antifungal activity and antipneumocystis activity.Type: GrantFiled: February 13, 1990Date of Patent: February 25, 1992Assignee: Merck & Co., Inc.Inventors: George M. Garrity, Sagrario M. Del Val, Mary Nallin, Dennis M. Schmatz, Jack L. Smith, Frank L. VanMiddlesworth, Kenneth E. Wilson, Marcia M. Zweerink
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Patent number: 5089479Abstract: The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.Type: GrantFiled: November 28, 1988Date of Patent: February 18, 1992Inventors: Howard C. Krivan, Victor Ginsburg, David D. Roberts
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Patent number: 5087567Abstract: An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.Type: GrantFiled: January 12, 1990Date of Patent: February 11, 1992Assignee: Bristol-Myers Squibb CompanyInventors: Thomas T. Dabrah, Grace A. Hesler, Sandra J. Hofstead, Kin S. Lam, Jacqueline M. Mattei, Daniel R. Schroeder, Koji Tomita
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Patent number: 5084563Abstract: 2-O-.alpha.-D-Glucopyranosyl-L-ascrobic acid is crystallizable in its supersaturated solution. Crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is substantially nonhygroscopic, free flowing, free of deliquescence, consolidation and direct reducing activity, but is readily soluble in water. Because of these, crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is handleable with an ease, and superiorly high in stability and physiological activities. Thus, crystalline 2-O-.alpha.-D-glucopyranosyl-L-acorbic acid is favorably useful in vitamin C-enriching agents, foodstuffs, pharmaceuticals and cosmetics.Type: GrantFiled: October 16, 1990Date of Patent: January 28, 1992Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Shuzo Sakai, Masaru Yoneyama, Toshio Miyake
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Patent number: RE34091Abstract: A sialic acid derivative having an active carbonyl group represented by the formula [I]: ##STR1## wherein R.sup.1 represents hydrogen or acetyl group; R.sup.2 represents hydrogen, a metal or a lower alkyl group; R.sup.3 represents hydrogen, hydroxyl gorup, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively. This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecules so that it shows high reactivity.Type: GrantFiled: October 21, 1991Date of Patent: October 6, 1992Assignee: MECT CorporationInventors: Shoji Yoshimura, Shohei Shibayama, Masaaki Numata, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa