Viscosity Or Degree Of Polymerization Changed (e.g., Degrading, Cross Linking, Etc.) Patents (Class 536/41)
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Patent number: 5081234Abstract: The present invention relates to antitumor 4'-demethylepipodophyllotoxin glycosides having the formula ##STR1## wherein R is a pentose selected from the group consisting of .beta.-D-ribopyranosyl, peracyl .beta.-D-ribopyranosyl, .beta.-D-xylopyranosyl, peracyl .beta.-D-xylopyranosyl, .alpha.-D-xylopyranosyl, peracyl .alpha.-D-xylopyranosyl, .alpha.-D-arabinopyranosyl, 3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, 2-O-acyl-3,4-O-(C.sub.1-4)alkylidene-D-ribopyranosyl, and .beta.-D-ribofuranosyl; P is hydrogen, or --PO.sub.3 H.sub.2 or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 30, 1990Date of Patent: January 14, 1992Assignee: Bristol-Myers Squibb Co.Inventors: Takeshi Ohnuma, Rika Obata
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Patent number: 5079350Abstract: A process for the production of an alkyl glycoside or an aqueous solution thereof is disclosed, comprising the steps of (1) reacting a sugar with alcohol to obtain an alkyl glycoside reaction product containing unreacted alcohol, (2) establishing a moving liquid film of the alkyl glycoside reaction product and (3) contacting the moving liquid film with steam or an inert gas at a temperature of from 50.degree. to 200.degree. C. The alkyl glycoside or aqueous solution thus obtained contains little unreacted alcohol and is excellent in hue and odor.Type: GrantFiled: March 29, 1990Date of Patent: January 7, 1992Assignee: Kao CorporationInventors: Tadaaki Fujita, Kiyoshi Aimono, Kunizo Hashiba, Koichi Ohori
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Patent number: 5077397Abstract: Sialic acid derivative with active ester groups expressed with the formula [I] ##STR1## Where R.sup.1 denotes hydrogen or an acetyl group, R.sup.2 denotes hydrogen or a lower alkyl group, R.sup.3 denotes C.sub.2 H.sub.4, C.sub.3 H.sub.6 or C.sub.2 H.sub.2, R.sup.4 denotes an hydroxyl group, the residue left after removing hydrogen from the alcohol portion of the active ester or alkyloxycarbonyloxy group, AC denotes an acetyl group, Ph denotes an phenyl group, and X denotes oxygen or sulfur. This sialic acid derivative has high reactivity because it has active ester groups in the molecules and can be used as a raw material or intermediate for synthesis of various sialic acid derivatives.Type: GrantFiled: November 27, 1989Date of Patent: December 31, 1991Assignee: MECT CorporationInventors: Shoji Yoshimura, Makoto Tanaka
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Patent number: 5077206Abstract: The invention provides a process for preparing L-rhamnose by hydrolyzing a rhamnosidic bond of a glycoside having rhamnose in a terminal position, by enzymatically hydrolyzing the glucoside with an enzyme combination comprising biological structural material degrading enzyme and a naringinase preparation which has a higher rhamnosidase activity than beta-glucosidase activity. Preferably the enzyme combination having rhamnosidase activity together with additional enzyme activity is a selected partially purified enzyme preparation having high rhamnosidase activity and low glucosidase activity together with biological structural material degrading activity. More preferably the additional enzyme activity is derived from an enzyme of the group consisting of protease, lipase, pectinase, cellulase and hemicellulase.Type: GrantFiled: November 21, 1988Date of Patent: December 31, 1991Assignee: Unilever Patent Holdings B.V.Inventors: Peter S. J. Cheetham, Michael A. Quail
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Patent number: 5077039Abstract: Substituted glucosides I(Glu.sub.m --R.sup.1)R.sub.n.sup.2 Iwhere Glu is a glucose unit, R.sup.1 is C.sub.8 -C.sub.18 -alkyl held by an acetal bond, R.sup.2 is C.sub.1 -C.sub.4 -alkyl or arylmethyl held by an ether bond, m is a mean value from 1 to 10 and n is a mean value from 0.1 to 2 m.Type: GrantFiled: September 27, 1989Date of Patent: December 31, 1991Assignee: BASF AktiengesellschaftInventors: Richard Baur, Jochen Houben, Alfred Oftring, Dieter Stoeckigt
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Patent number: 5075433Abstract: A novel 3-sulfatoglucuronic acid-containing compound is produced. A method for antibody removal from a liquid sample, and a method of treatment for antibody-related disorders is disclosed, along with a diagnostic kit.Type: GrantFiled: August 5, 1988Date of Patent: December 24, 1991Assignee: Eastman Kodak CompanyInventor: Alexander L. Weis
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Patent number: 5071598Abstract: Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable distance from the hydrophobic portion of the molecule by means of a hydrophilic linker unit. A method for the use of the compositions is also provided.Type: GrantFiled: December 11, 1989Date of Patent: December 10, 1991Assignee: California Institute of TechnologyInventors: John D. Baldeschwieler, Raymond P. Goodrich, Jr.
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Patent number: 5071971Abstract: An external skin care preparation comprising a compound represented by the following general formula (I) or (II), or a salt thereof: ##STR1## wherein R.sup.1 means an aliphatic hydrocarbon group having 9-25 carbon atoms, A and B denote specific groups respectively, R.sup.6 and R.sup.7 are individually an aliphatic hydrocarbon group having 10-26 carbon atoms, and R.sup.8 denotes a group --CH.sub.2 CH.sub.2 OH, --CH.sub.2 COOH, or --COCH.sub.3.Type: GrantFiled: September 19, 1990Date of Patent: December 10, 1991Assignee: Kao CorporationInventors: Shinji Yano, Akira Kawamata, Yoshihiro Minematsu, Shuichi Akazaki, Mitsuko Zama, Genji Imokawa, Naotake Takaishi, Tsuyoshi Ohtomo, Takashi Komori
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Patent number: 5071973Abstract: The present invention refers to a method concerning the preparation of hemo-compatible substrates by incorporation, adhesion and/or modification and embodiment of non-thrombogenic endothelial cell surface polysaccharide (HS I) in its peptide-bound or free form on and/or mixed with synthetic and biopolymers (Substrates) by way of physical distribution, adhesion to the surface and/or chemical embodiment, which can be used in medicine as blood-compatible substrates. These polymers can be presented in form of fibres, hollow fibres, membranes, organ spare parts, canulas, syringes, tubes, blood containers, or in other forms, or they can be prepared from other material.Type: GrantFiled: September 27, 1990Date of Patent: December 10, 1991Inventors: Ruprecht Keller, Hanno Baumann
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Patent number: 5070191Abstract: An antifungal compound, demethylallosamidin, represented by the formula: ##STR1## is disclosed. Methods of production and antifungal compositions comprising demethylallosamidin are also provided.Type: GrantFiled: April 27, 1990Date of Patent: December 3, 1991Assignee: Ajinomoto Co., Inc.Inventors: Yasuhiro Yamada, Shohei Sakuda, Seiji Takayama
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Patent number: 5068180Abstract: A substrate for .beta.-galactosidase having the general formula ##STR1## wherein X is halogen; Y is halogen, lower alkyl or hydrogen; W is lower alkyl or hydrogen; and Z is nitro.Type: GrantFiled: November 8, 1989Date of Patent: November 26, 1991Assignee: Technicon Instruments CorporationInventors: Deng R. Hwang, Mary Ellen A. Scott
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Patent number: 5068339Abstract: Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for triggering the dioxetanes to produce light from the flurorescent molecule in the group as a signal.Type: GrantFiled: November 13, 1989Date of Patent: November 26, 1991Assignee: Board of Governors of Wayne State UniversityInventors: Arthur P. Schaap, Hashem Akhavan-Jaffi
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Patent number: 5066645Abstract: The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.Type: GrantFiled: September 1, 1989Date of Patent: November 19, 1991Assignee: Bristol-Myers CompanyInventors: Takeshi Ohnuma, Hideaki Hoshi, Hideo Kamei, Takayuki Naito
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Patent number: 5066794Abstract: Disaccharide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 CO-- and R.sup.2 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms and having a hydroxyl group at the 3-position thereof; R.sup.3 CO-- and R.sup.4 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms; and m and n each represents an integer of from 8 to 12, and the salts thereof. The compounds exhibit biological activities equal to or higher than those of natural lipid A. Also, the compounds of this invention are very useful as standard reagent for determination of endotoxin in the samples to be tested.Type: GrantFiled: January 29, 1990Date of Patent: November 19, 1991Assignee: Daiichi Pharmaceutical Co., Ltd.Inventor: Tetsuo Shiba
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Patent number: 5061695Abstract: An antitumor substance BE-12406 or a pharmaceutically acceptable salt thereof, which is represented by the general formula ##STR1## and a method of producing the novel substance.Type: GrantFiled: January 30, 1990Date of Patent: October 29, 1991Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Hiroyuki Suda, Katuhisa Kojiri, Akira Okura, Koutaro Funaishi, Kenji Kawamura, Masanori Okanishi
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Patent number: 5057605Abstract: Sialocylglycerolipids represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group CH.sub.3 CO--; R.sup.2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom or a group C.sub.n H.sub.2n+1 -- (n is an integer ranging from 1 to 30); and R.sup.4 represents a group C.sub.m H.sub.2n+1 -- (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.Type: GrantFiled: November 10, 1988Date of Patent: October 15, 1991Assignee: Mect CorporationInventors: Shoji Yoshimura, Yuzi Matsuzaki, Mamoru Sugimoto, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Patent number: 5057540Abstract: Substantially pure saponins are disclosed. The saponins of the present invention are useful as immune adjuvants. Disclosed as well are immune response-provoking compositions comprising an antigen in admixture with the substantially pure saponins.Type: GrantFiled: August 27, 1990Date of Patent: October 15, 1991Assignee: Cambridge Biotech CorporationInventors: Charlotte A. Kensil, Dante J. Marciani
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Patent number: 5053498Abstract: A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or .dbd.O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.5 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A);.dbd.C.dbd.CH--COR.sub.8 (A)or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5, R.sub.4 represents OR.sub.7 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.Type: GrantFiled: October 16, 1989Date of Patent: October 1, 1991Assignee: Green Cross CorporationInventors: Yusei Shiraga, Chikara Fukaya, Toshiaki Akira, Masakazu Iwai, Kazumasa Yokoyama, Mamoru Tabata, Hiroshi Fukui, Shigeo Tanaka, Yoshiro Iga, Tadakazu Suyama, Kanemichi Okano
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Patent number: 5051408Abstract: A process for preparing gamma inulin comprising the steps of (a) recrystallizing crude inulin from water at a temperature below 37.degree. C. to obtain a suspension, (b) heating the suspension at a temperature of from about 25.degree. to 45.degree. C. for about 1-3 days, (c) further heating the suspension at a temperature of about 40.degree. to 55.degree. C. for about 0.5 to 1.5 hours, and (d) isolating insoluble gamma inulin from the suspension. A composition comprising particles of inulin or an inulin derivative in the gamma polymorphic form is characterized in that the particles have a low rate of solution in aqueous media above 30.degree. C., particularly above 37.degree. C. The composition is effective as the active component of an immunotherapeutic preparation for activation of the alternative pathway of complement, or for antitumor treatment.Type: GrantFiled: March 30, 1990Date of Patent: September 24, 1991Assignee: The Australian National UniversityInventor: Peter Dodd Cooper
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Patent number: 5049549Abstract: 7-O-Glycosyl-rhodomycins which correspond to the general formula I below ##STR1## in which the radicals have the following meaning: R.sup.1 is a hydrogen atom or a hydroxyl group,R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl group,R.sup.3 a hydroxyl group, an O-acyl protective group or the methyloxycarbonyl group,R.sup.4 is a hydrogen atom, an O-acyl protective group, an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group andR.sup.5 is an azido group, amino or trifluoroacetylamino group, a di-C.sub.1 -C.sub.4 -alkylamino group or cyanomethylamino group,where acyl protective group denotes an acetyl, mono-, di- or trihalogenoacetyl group with fluorine or chlorine as halogen or the p-nitrobenzoyl group, and a process for the preparation thereof and the use thereof as pharmaceuticals, are described.Type: GrantFiled: December 18, 1989Date of Patent: September 17, 1991Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Hans P. Kraemer, Konrad Dehmel
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Patent number: 5049664Abstract: A trehalose derivative of the formula: ##STR1## wherein one, two, three or four of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are independently selected from the group consisting of C.sub.1-40 aliphatic acyl groups and all the rest of them are hydrogen atoms,with the proviso that:a) when one of them is C.sub.1-40 aliphatic acyl group, then it is not 2-palmitoyl or 6-aliphatic acyl,b) when two of them are C.sub.1-40 aliphatic acyl groups, then they are not located at corresponding positions with each other,c) when three of them are C.sub.1-40 aliphatic acyl groups, then they are not 2,3,2'-tripalmitoyl, andd) when four of them are C.sub.1-40 aliphatic acyl groups, then they are not located at corresponding positions with each other or at 2,3,4,2'- or 2,3,6,2'-positions.The compounds of the above formula have anti-tumor activity.Type: GrantFiled: August 16, 1989Date of Patent: September 17, 1991Assignee: Sawai Pharmaceutical Co., Ltd.Inventors: Junji Yoshinaga, Takeshi Shogaki, Takao Kakita, Hiromi Ozeki, Yoshiko Kato
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Patent number: 5047518Abstract: Herbicidal and/or plant-growth regulatory compositions comprising, together with a carrier and/or surface-active agent, an effective amount of at least one herbicidal and/or plant growth regulatory active agent selected from compounds of formula (I) ##STR1## (in which R represents an optionally substituted aralkyl group,X represents an O--, N-- or S-linked organic group, an optionally substituted hydrocarbyl group, a halogen atom, a hydroxy, amino, alkoxyamino, nitro, cyano, azido, sulpho or phospho group, or together with the group R.sup.2e, X may represents a ketonic oxygen atom --O-- or a group of formula --CH.sub.2 O--;R.sup.1e represents a hydrogen atom or an optionally substituted hydrocarbyl group, or a formyl group;R.sup.2e represents a hydrogen atom, a hydroxy group or an optionally substituted hydrocarbyl or O-linked hydrocarbyl group,or, together with the group X, R.sup.2e may represent a ketonic oxygen atom --O-- or a group of formula --CH.sub.2 O--;R.sup.Type: GrantFiled: April 10, 1990Date of Patent: September 10, 1991Assignee: Her Majesty the Queen in right of New ZealandInventors: Richard H. Furneaux, Ronald F. Henzell, Peter C. Tyler
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Patent number: 5045532Abstract: A pharmaceutical composition is provided comprising inner ester ganglioside derivatives useful for its peripheral analgesic-antiinflammatory activity in treating pain caused by pathologies of the peripheral nervous system and which can advantageously be administered orally.Type: GrantFiled: October 20, 1988Date of Patent: September 3, 1991Assignee: Fidia, S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 5041541Abstract: Disclosed are novel 5-C-hydroxymethylhexose compounds and their derivatives which exhibit sugar-like functionality when used in food compositions. The derivatives include stereoisomers, di-, tri-, and polysaccharides, alkyl glycosides, polyol, and alditol derivatives. Also disclosed are sugar substitute compositions and food compositions containing these compounds and their derivatives.Type: GrantFiled: April 20, 1989Date of Patent: August 20, 1991Assignee: The Procter & Gamble CompanyInventor: Adam W. Mazur
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Patent number: 5037973Abstract: The invention relates to bisaldonamides, in which the underlying aldonic acids can be linked glycosidically in the 3-, 4- or 6-position with a galactopyranosyl, mannopyransyl, glucopyranosyl or oligopyranosyl radical. They are starting products for the preparation of the corresponding polysulfuric acid esters.Type: GrantFiled: October 12, 1988Date of Patent: August 6, 1991Assignee: Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co.Inventor: Eike Meinetsberger
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Patent number: 5037651Abstract: Dihydro derivatives of LL-E33288, BBM-1075 FR-900405, FR-900406, PD 114759, PD 115028, CL-1577A, CL-1577B, CL-1577D, CL-1577E and CL-1724 antibiotics/antitumor agents are disclosed and described, including the degradation product of LL-E33288 antibiotics/antitumor agents dihydro-LL-E33288-pseudoaglycone.Type: GrantFiled: January 30, 1987Date of Patent: August 6, 1991Assignee: American Cyanamid CompanyInventor: May D. Lee
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Patent number: 5037969Abstract: The invention provides a compound of the formula (I): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --Z wherein R is a glycosyl group, m is an optional positive integer, n is an integer from 1 to 3 and Z is --CHO, --CH.sub.2 OH or --COOH.The compound of the formula (I'): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --CHO wherein R, m and n are as defined above and the formula (I"'): R--OCH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --COOH wherein R, m and n are as defined above is useful as a chemically modifying agent for protein.The compound of the formula (I"): R--O--CH.sub.2 CH.sub.2 O.sub.m CH.sub.2).sub.n --CH.sub.2 OH wherein R, m and n are as defined above is useful as a protein fractionating agent.Type: GrantFiled: June 4, 1990Date of Patent: August 6, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Isao Minami, Hayao Ueno, Masahiko Fujino
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Patent number: 5036055Abstract: The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia.Type: GrantFiled: June 7, 1989Date of Patent: July 30, 1991Assignee: Bristol-Myers CompanyInventors: Takeshi Ohnuma, Rika Obata, Hideo Kamei, Takayuki Naito
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Patent number: 5034517Abstract: 2,6-Dideoxy-2-fluoro-L-talopyranose and 1-substituted derivatives thereof, including methyl 2,6-dideoxy-2-fluoro-L-talopyranoside and 3,4-di-O-protected-2,6-dideoxy-2-fluoro-L-talopyranosyl halides, are now provided and these new compounds are useful as intermediates for use in the synthesis of new compounds having antitumor activity, especially 7-O-(2,6-dideoxy-2-fluoro-.alpha.-L-talopyranosyl) daunomycinone or -adriamycinone. 2,6-Dideoxy-2-fluoro-L-talopyranose shows antibacterial activity. 2,6-Dideoxy-fluoro-L-talopyranose and the 1-substituted derivatives thereof may be produced by a multi-stage process starting from L-fucose.Type: GrantFiled: March 6, 1990Date of Patent: July 23, 1991Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Tomio Takeuchi, Yasushi Takagi
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Patent number: 5034380Abstract: Novel cyclic orthoesters and orthocarbonates of 4'-demethylepipodophyllotoxin glucoside are disclosed in the present invention. These compounds are active against experimental murine P388 leukemia.Type: GrantFiled: November 20, 1989Date of Patent: July 23, 1991Assignee: Bristol-Myers Squibb CompanyInventors: Takeshi Ohnuma, Takayuki Naito, Hideo Kamei
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Patent number: 5034516Abstract: A compound X-Y wherein X comprises sialic acid, a sialic acid derivative or an oligosaccharide terminating in a sialic acid or sialic acid derivative if multibranched at the end of at least the largest branch, and, Y represents coupling means which allows an antibody to be raised to X when the compound is coupled to a carrier through the coupling means Y and the coupled compound used to raise said antibody. These compounds show utility in that they, and antibodies raised against these, can be used in detecting and diagnosing cancers.Type: GrantFiled: August 4, 1987Date of Patent: July 23, 1991Assignee: University of OttawaInventors: Rene Roy, Craig A. Laferriere
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Patent number: 5032505Abstract: Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.Type: GrantFiled: November 21, 1988Date of Patent: July 16, 1991Assignee: Chembiomed, Ltd.Inventors: James M. Pierce, Ole Hindsgaul
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Patent number: 5030723Abstract: A substantially pure unbranched ceramide polysaccharide type 2 chain compound having the following structure: ##STR1## wherein Gal represents galactose, GlcNAc represents N-acetylglucosamine, Fuc represents fucose Glc represents glucose and Cer represents ceramide. A substantially pure unbranched ceramide polysaccharide type 2 chain compound having the following structure: ##STR2## wherein Gal represents galatose, GlcNAc represents N-acetylglucosamine. Fuc represents fucose, Glc represents glucose, Cer represents ceramide and NeuAc represents sialic acid. Antibodies that are specific to portions of the above-described compounds, wherein the portions comprise the internal .alpha.1-.fwdarw.3 fucosyl residue and/or the terminal sialic acid residue. Immuogens for producing antibodies to the above-described compounds or portions thereof. A method of actively immunizing against tumors that express the above-described compounds.Type: GrantFiled: May 31, 1988Date of Patent: July 9, 1991Assignee: The Biomembrane InstituteInventors: Edward D. Nudelman, Steven B. Levery, Mark R. Stroud, Mary Ellen K. Salvan, Sen-itiroh Hakomori
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Patent number: 5030721Abstract: Novel N-acetyl-.beta.-D-glucosamine derivatives represented by the following formula: ##STR1## wherein R represents a hydrogen atom or an acyl group; and X represents a nitrogen atom or an oxide of nitrogen, are disclosed. The glucosamine derivatives are useful for determination of N-acetyl-.beta.-D-glucosaminidase in body fluids as an index of renal diseases.Type: GrantFiled: February 2, 1989Date of Patent: July 9, 1991Assignee: Kikkoman CorporationInventors: Kouichi Kasai, Shoichi Tokutake, Nobuyuki Yamaji
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Patent number: 5026548Abstract: A surfactant for use as a viscosity reducing agent in chocolate, or an emulsifier, surfactant or foam stabilizer in the food and other industries is produced by extracting oats using an alcohol such as ethanol or propanol, extracting the alcohol extract with methanol and evaporating the methanol. The alcohol extraction may be preceded by extraction with a non-polar solvent such as hexane. A water-soluble surfactant can be produced by extracting the methanol extract with acetone and recovering the acetone-insoluble material.Type: GrantFiled: December 28, 1988Date of Patent: June 25, 1991Assignee: Cadbury Schweppes plcInventors: Roger Evans, Michael H. Jee, Nigel H. Sander, Ian H. Smith, Raymond K. Gibson
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Patent number: 5019568Abstract: Disclosed are pharmaceutical compositions for enhancing human host resistance against opportunistic infection in an individual immunocompromised by an AIDS-related virus, consisting essentially of an anti-viral, anti-AIDS drug selected from the group consisting of ansamycin, ribavirin, dideoxycitidine, HPA-23, AL-721, foscarnet, and azidothymidine and a glycolipid compound consisting essentially of the formula: ##STR1## where: R.sup.1 is .alpha. or .beta.-D-1-thiomannopyranoside, .alpha. or .beta.-L-1-thiofucopyranoside.Type: GrantFiled: June 21, 1989Date of Patent: May 28, 1991Assignee: Merck & Co., Inc.Inventors: Philippe L. Durette, William K. Hagmann, Mitree M. Ponpipom
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Patent number: 5017229Abstract: A water insoluble, biocompatible gel that includes the reaction product of hyaluronic acid, a polyanionic polysaccharide, and an activating agent.Type: GrantFiled: June 25, 1990Date of Patent: May 21, 1991Assignee: Genzyme CorporationInventors: James W. Burns, Steven Cox, Alan E. Walts
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Patent number: 5013827Abstract: Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for triggering the dioxetanes to produce light from the fluorescent molecule in the group as a signal.Type: GrantFiled: November 13, 1989Date of Patent: May 7, 1991Assignee: Board of Governors of Wayne State UniversityInventor: Arthur P. Schaap
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Patent number: 5011923Abstract: A polyacetyl oligosaccharide derivative is described, represented by formula (I) ##STR1## wherein A represents a nitro group or an amino group; Ac represents an acetyl group (CH.sub.3 CO-); and n represents 0 or an integer of from 1 to 8,and a glucose heptamer having a biotin moiety at one end-group and a development nucleus-forming moiety at the other end-group which is derived from the compound of formula (I) is also described. The latter compound is useful as a substrate for enzyme activity assay systems.Type: GrantFiled: February 21, 1990Date of Patent: April 30, 1991Assignee: Fuji Photo Film Co., Ltd.Inventors: Mitsunori Ono, Nobuo Suzuki
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Patent number: 5010185Abstract: Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials.Type: GrantFiled: June 13, 1989Date of Patent: April 23, 1991Assignee: Pfizer Inc.Inventor: Frank J. Urban
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Patent number: 5010058Abstract: Derivatives of 1,2-O-isopropylidene-.alpha.,D-glucofuranose and intermediates for preparing these derivatives are described. These derivatives are useful for treating animals and mammals with inflammatory and/or autoimmune disorders such as autoimmune deficiency syndrome, psoriasis, atopic dermatitus, rheumatoid arthritis, osteoarthritis, scleroderma and systemic lupus erythematosus.Type: GrantFiled: June 22, 1989Date of Patent: April 23, 1991Assignee: 501 Greenwich Pharmaceuticals IncorporatedInventors: Bruce Ronsen, Sudershan K. Arora, Albert V. Thomas
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Patent number: 5008382Abstract: Cationic aqueous bituminous emulsion-aggregate slurries are disclosed to be formed with cationic emulsions prepared at elevated temperatures by emulsifying bitumen, such as an asphalt, in water with a cation-active emulsifier which is the product of the reaction of a sugar-containing syrup with modified polyamine which is the reaction product of a polyamine with certain polycarboxylic acids and anhydrides.Type: GrantFiled: July 20, 1989Date of Patent: April 16, 1991Assignee: Westvaco CorporationInventors: Peter Schilling, Hans G. Schreuders
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Patent number: 5008381Abstract: Naringin is selectively cleaved into L-rhamnose and naringenin-t-7-glucoside by heating naringin in solution under particular conditions of acid hydrolysis. Upon cooling the reaction medium, a liquid phase containing L-rhamnose and a semi-solid phase containing naringenin-7-O-glucoside are obtained from which those compounds may be isolated.Type: GrantFiled: February 23, 1990Date of Patent: April 16, 1991Assignee: Nestec S.A.Inventors: Zdenek Kratky, John S. Tandy
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Patent number: 5008383Abstract: Novel surface-active compositions are prepared by reacting a diketene prepared from a fatty acid or fatty acid chloride with 8-22 carbon atoms with a substance having a hydrophlic moiety and a hydroxyl or amino group containing one or more active hydrogens. The active hydrogen-containing group is acylated by the diketene and the resulting product contains the hydrophillic moiety and also branched 2-alkyl-3-ketoacyl chains.Type: GrantFiled: November 3, 1988Date of Patent: April 16, 1991Assignee: 31 Research Exploitation LimitedInventors: John D. Bu'lock, James K. Sutherland, Michael J. Donnelly
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Patent number: 5006647Abstract: A disaccharide compound represented by formula (I): ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the specification and a salt thereof are disclosed. The compound exhibits excellent antitumor activity and low toxicity and is useful as an antitumor agent.Type: GrantFiled: March 2, 1988Date of Patent: April 9, 1991Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Tsuneo Kusama, Tsunehiko Soga, Tetsuo Shiba
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Patent number: 5004833Abstract: Disclosed are KS-501 derivatives represented by the formula (I) ##STR1## wherein X represents a hydrogen atom or COOR.sub.3, Y represents hydroxy or ##STR2## and R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R.sub.1, R.sub.2 and R.sub.3 are simultaneously hydrogen atoms, and when R.sub.1, R.sub.2 and X are simultaneously hydrogen atoms, Y does not represent ##STR3## and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.Type: GrantFiled: September 15, 1989Date of Patent: April 2, 1991Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Toru Yasuzawa, Satoshi Nakanishi, Chikara Murakata, Hiroshi Kase, Hiroshi Sano, Koji Yamada
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Patent number: 5003061Abstract: A method for preparing high-purity crystalline lactulose and the product obtained by the method, which comprises crystallization from aqueous solutions at a temperature of 5.degree.-40.degree. C., the starting aqueous solution having a lactulose concentration of 50-80% w/w, a lactose concentration of less than 5% of the lactulose concentration by weight, a galactose concentration of less than 5% of the lactulose concentration by weight, and a concentration of other sugars of less than 4% of the lactulose concentration by weight.Type: GrantFiled: January 11, 1988Date of Patent: March 26, 1991Assignee: SIRAC SrlInventors: Renato Carobbi, Franco Innocenti
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Patent number: 5003057Abstract: A process for preparing glycosides from a source of saccharide moiety and an alcohol in the presence of a hydrophobic acid catalyst is provided. An example of such a catalyst is dinonylnaphthalenemonosulfonic acid. The use of such catalysts provides a number of process advantages, which includes the reduced production of polar by-products. Preferred glycosides produced by the process are higher alkyl glycosides useful as surfactants.Type: GrantFiled: December 23, 1988Date of Patent: March 26, 1991Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Patrick M. McCurry, William Kozak, Carl Pickens
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Patent number: 5001114Abstract: New alkyl mono and polyglycoside phosphate esters and anionic derivatives thereof are described which compounds have the general formulaRO(G).sub.x Z.sub.ywhereinG is a glycosyl moiety which is selected from the group consisting of fructose, glucose, mannose, galactose, talose, gulose, allose, altrose, idose, arabinose, xylose, lyxose, ribose or mixtures thereof,R is an aliphatic or aromatic hydrocarbon group substituted on the glycosyl moiety which aliphatic or aromatic group is a straight chain or is branched, or is cyclic, saturated or unsaturated and has 6 to 30 carbon atoms;x=1 to 10;y=1 to 3.times.+1;at least one of the hydroxyl groups at the hydroxyl position of at least one of the glycosyl moieties is substituted with Z which is ##STR1## wherein A=R.sub.1, H.sup.+ or (G).sub.x ORB=R.sub.2, M.sup.+ or (G).sub.x ORexcept that when B--R.sub.2 or (G).sub.x OR, A.noteq.H, when A or B=(G).sub.x OR, Z substitutes one of the hydroxyl groups of the glycosyl moieties of A or B, and R.sub.1 and R.sub.Type: GrantFiled: October 27, 1989Date of Patent: March 19, 1991Assignee: Henkel Kommanditgesellschaft auf AktienInventor: Robert S. McDaniel, Jr.
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Patent number: 4999423Abstract: A novel acylated anthocyanin of the formula: ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom, a ferulyl group or a caffeyl group; R.sup.3 and R.sup.4 may be the same or different and each represents a ferulyl group or a caffeyl group; and ANION.sup.- represents an anion) and a process for producing the same, as well as a pigment composition containing said anthocyanin.Type: GrantFiled: March 11, 1988Date of Patent: March 12, 1991Assignee: Suntory LimitedInventor: Eiichi Idaka