The Hetero Ring Is Ortho-fused To The D Ring Patents (Class 540/63)
At least six cyclos in the polycyclo ring system (Class 540/64)
Nitrogen or acyclic chalcogen bonded directly to the hetero ring (e.g., cyclic carbonates, etc.) (Class 540/65)
The a ring is a benzene ring (Class 540/66)
Sulfur or nitrogen attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding (Class 540/67)
Halogen attached indirectly to the cyclopentanohydrophenanthrene ring system by acyclic nonionic bonding (Class 540/68)
Halogen bonded directly to the cyclopentanohydrophenanthrene ring system (Class 540/69)
Oxygen attached directly to the b ring or indirectly to the a or b ring by acyclic nonionic bonding (Class 540/71)
  • Stable, crystalline flunisolide
    Patent number: 4933168
    Abstract: A unique crystalline polymorphic form of flunisolide is disclosed which is stable in aerosols such as Freon.RTM. mixtures and is valuable in the treatment of respiratory diseases, particularly bronchial asthma and allergic rhinitis.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: June 12, 1990
    Assignee: Syntex Pharmaceuticals International Limited
    Inventors: Richard E. Jones, Gisela T. Haringer
  • Method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
    Patent number: 4925933
    Abstract: A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives characterized in reaction of a corresponding 16,17-acetonide with an aldehyde or ketone in (a) hydrocarbon solvent wherein the solubility of the pregnane derivative is less than 1 mg/l or in a halogenated hydrocarbon solvent together with a hydrohalogen acid or an organic sulphonic acid as catalyst and in the presence of small grains of an insert material in the reaction medium or (b) a halogenated hydrocarbon solvent together with a hydrohalogen acid an organic sulphonic acid as catalyst and in the presence of an epimeric distribution modifier.
    Type: Grant
    Filed: September 11, 1987
    Date of Patent: May 15, 1990
    Assignee: Astra Pharmaceutical Production Aktiebolag
    Inventors: Edib Jakupovic, Roy T. Sourander, Jan U. Stenhede, Rolf P. Svensson
  • 16,17 acetals of pregnane derivatives and pharmaceutical compositions containing them
    Patent number: 4835145
    Abstract: A compound exhibiting anti-inflammatory properties having the formula ##STR1## in which X is H, Hal or CH.sub.3 COO--; R.sub.1 is CH.sub.3 (CH.sub.2).sub.2 CH--; and R.sub.2 and R.sub.3 are separately H or Hal; and a pharmaceutical composition containing the same.
    Type: Grant
    Filed: January 2, 1987
    Date of Patent: May 30, 1989
    Assignee: Sicor Societa' Italiana Corticosteroidi S.p.A.
    Inventor: Peter MacDonald
  • Process for the preparation of 16,17 acetals of pregnane derivatives
    Patent number: 4695625
    Abstract: A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described.In the instance of the preparation of 16.alpha.,17.alpha.-butylidenedioxy-11.beta.,21-dihydroxypregna-1,4-diene- 3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods.New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: September 22, 1987
    Assignee: Sicor Societa Italiana Corticosteroidi S.p.A.
    Inventor: Peter Macdonald
  • Liposomes containing steroid esters
    Patent number: 4693999
    Abstract: Pharmaceutical composition for administration primarily to the respiratory tract when treating and controlling anti-inflammatory conditions comprising liposomes in combination with a compound of the formula ##STR1## and R.sup.1 is a saturated or unsaturated, straight or branched alkyl group with 11-19 carbon atoms and R is H, --COCH.sub.3, --COC.sub.2 H.sub.5, --CO(CH.sub.2).sub.2 CH.sub.3 or --CO(CH.sub.2).sub.3 CH.sub.3.The invention also refers to the compounds of the formula I per se processes for preparation of these compounds and to a method for the treatment of inflammatory conditions.
    Type: Grant
    Filed: July 3, 1985
    Date of Patent: September 15, 1987
    Assignee: Aktiebolaget Draco
    Inventors: Bengt I. Axelsson, Ralph L. Brattsand, Carl M. O. Dahlback, Leif A. Kallstrom, Jan W. Trofast
  • Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
    Patent number: 4613463
    Abstract: This invention discloses an improved process for the production of corticoids from 17.alpha.-hydroxy steroids utilizing peroxymonosulfate.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: September 23, 1986
    Assignee: The Upjohn Company
    Inventor: Clifford E. Sacks