Patent number: 6642273
Abstract: An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula:
in which:
X represents:
a divalent radical of formula:
and Y represents a divalent radical of following formula:
R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6,
p being 0, 1, 2 or 3,
t being 0, 1 or 2,
R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical,
R5 represents H, lower alkyl, —OR8 or
R6 represents H or lower alkyl,
R7 represents lower alkyl,
R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid,
r′ and r″, which are identical or different, represent H, low
Type:
Grant
Filed:
August 9, 2002
Date of Patent:
November 4, 2003
Assignee:
Galderma Research & Development
Inventors:
Angel De Lera, Beatriz Dominguez
Publication number: 20020155496
Abstract: The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among —COOR5, —CONR1R2, —COONR3R4, —COR6, —CON, —COOR5, —CHOHR7, —SR8, —OR8, —CN, —CNO, —CNS, —NCO, —NCS and —R1R2CR9; wherein R1, R2, R3 and R4 represent a hydrogen atom, a C1-C10 alkyl, a C6-C20 aryl optionally substituted, a C7-C10 alkene, a C1-C10 alkyne, or an aminoacyl or peptidyl optionally substituted; or R1 and R2 or R3 and R4 together form a cycle or a heterocycle; R5 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R6 represents a hydrogen, a halogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R7 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; R8 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; and R9 is selected among
Type:
Application
Filed:
January 30, 2001
Publication date:
October 24, 2002
Inventors:
Marie Helene Charles, Nadia Piga, Nicole Battail-Poirot, Laurent Veron, Thierry Delair, Bernard Mandrand