Abstract: The device includes an electrolysis cell (C) comprising: a closed variable volume first chamber (2) containing an electrolyte that gives off gas under the effect of an electrolysis voltage applied to electrodes (3, 4) in contact with the electrolyte, the gas given off causing the first chamber to expand; and a variable volume second chamber (7) containing the active principle, said second chamber opening out to the outside via an orifice (11) enabling the active principle to be delivered; the total volume of the two chambers (2, 7) being constant, such that expansion of the first chamber causes the volume of the second chamber to be reduced and gives rise to a corresponding controlled expulsion of the active principle contained therein.

Abstract: The present invention is directed to an ambulatory infusion device having a housing which has a series of cavities in which there are provided expandable pressure regulator tubes which may be formed of suitable resilient materials. The regulator tubes may be of several different configurations. The cavities have a greater volume than the expandable tubes to permit expansion thereof and also to provide means for limiting the expansion thereof to ensure against bursting of the tubes should a pressure relief valve in the system fail to operate. The open ends of the regulator tubes are interconnected through a series of passageways, connectors, etc. to an inflatable, flexible, substantially non-stretchable diaphragm provided in another housing cavity. A fresh flexible bag of medicament is positioned against the diaphragm by the patient with an administration port of the bag projecting outwardly of the housing for connection to an infusion set connectable to a patient's catheter.

Abstract: The specification discloses a disposable low-cost constant pressure infusion pump intended to be used with an infusion cuff, or other infusion device for the infusion of sterile physiological solutions into the human body. The device utilizes an enclosure, which may be an infusion cuff or a pressurizing chamber that is adapted to receive a disposable bag of physiological solutions therewithin. A pressurizing chamber is formed about and around the bag of physiological solution, to define a pressure chamber to which is supplied a regulated pressure. The regulated pressure is provided from a small low-cost disposable canister of freon or other pressurizing fluid through a pressure regulating mechanism. The canister is equipped with a springloaded discharge valve, and the pressure regulating mechanism balances the spring constant of this discharge valve against an elastic wall or other resilient diaphragm to balance the loading between the elastic wall and springloaded discharge valve.

Abstract: Process and apparatus for quickly removing contaminated tissue and blood from a localized skin wound in the body of a human being immediately after contamination has occured by removing all of the tissue from the wound by use of a biopsy punch and removing the contaminated blood from the wound by suction from a vacuum pump.

Abstract: An insert head (102) is tightly inserted in the rearward end of a commercially available ampoule (101) equipped with a plunger (100). A galvanic, gas-generating cell is arranged in the insert head (102). The plunger (100) is driven forward by the gas generated by this cell. A throttle device (103) constituted by a capillary tube is connected to the Luer's syringe (109) of the ampoule (101), the infusion fluid driven out by the plunger (100) flowing through this throttle means into a catheter (104).

Abstract: Inert or biologically active particles are propelled at cells at a speed whereby the particles penetrate the surface of the cells and become incorporated into the interior of the cells. The process can be used to mark cells or tissue or to biochemically affect tissues or tissue in situ as well as single cells in vitro. Apparatus for propelling the particles toward target cells or tissues are also disclosed. A method for releasing particles adhered to a rotor device is also disclosed.

Abstract: A system and method for administering a drug, at a selected dose, via the respiratory tract. Spray-dried liposome particles containing the selected dose of the entrapped drug are released into the air in aerosolized form, either by entrainment in an air or propellant stream, or by release from a pressurized can containing a suspension of the liposomes in a fluorchlorocarbon solvent.

Abstract: A dispenser is enclosed for delivering a beneficial agent to an enviroment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, a beneficial agent in the first means, and a second means in the dispenser for aiding in displacing the first means from the dispenser.

Abstract: An infusion device for dispensing drugs and other fluids at controlled rates over extended time periods. The device includes a syringe section and a power section that are connected together in use, the power section having a casing defining a first chamber containing a vacuum-stable viscous liquid and a second chamber under partial vacuum. A metering passage extends between the two chambers, and a piston is slidably received in the casing and constitutes a movable wall of the first chamber so that as the viscous liquid gradually flows through the metering passage into the second chamber the piston retracts slowly to cause fluid to be discharged from the syringe.

Abstract: A prefilled ampoule-syringe including an ampoule body having a smaller inner dimension than the body and a stopper means associated with an external capsule for closing the ampoule. The stopper is provided with an internal conduit having at least one transverse branch opening into a longitudinal branch between the interior of the capsule body and a needle-holding tip. The capsule is arranged for actual movement from a position within the neck where it is in a closed position to an open injection position within the ampoule body. When the capsule is in the position in the neck of the ampoule, the contents of the ampoule are in contact only with the walls of the ampoule and the inner surface of the stopper which faces into the neck. When the stopper is moved to injection position, the contents of the ampoule pass through the transverse passage and down the longitudinal passage to the needle holding tip for injection into a patient.

Abstract: A device for infusing a drug into an ambulatory patient, the drug being contained in a transparent spiral conduit which is embedded in a disposable flexible casting conformingly adhered to the patient's body, includes a reusable micropump module which is detachably mounted in a collar valve on the casting and forces oxygen into the conduit under pressure to expel the drug into a semi-pivoting cannula inserted into the patient's body. A colored oil drop between the oxygen and the drug in the conduit provides a visual indication of drug quantity, while a filter with hydrophobic and hydrophylic membranes keeps the oxygen and oil substantially out of the cannula.

Abstract: An apparatus for ambulatory intravenous delivery of substances to a recipient comprising a container and delivery means for pressurized delivery of the substance. The container communicates with a source of pressurized gas to provide the pressurizing force and is uniquely attachable to the recipient so as to provide portability to the system. The flow rate is controlled by feedback electronics connected to a flow rate meter and a throttle valve. The flow rate meter has a heating resistor in the flow path of the substance and a thermistor to detect a temperature rise in the substance downstream from the resistor. A constriction in the flow tube is disposed between the resistor and thermistor to cause a flat wavefront of temperature increase. The throttle valve is a pin disposed partially within a tube to form an annular gap. The flow rate is adjusted by changing the distance the pin extends into the tube and thereby change the length of the annular gap.

Abstract: A medication infusion device (10) wherein a septum fitting (14) includes a housing (50) that cooperates with an annular band (68) and a septum (66) to define a cavity (80). A poppet (84) cooperates with a seating ring (88), annular band (68) and septum (66) to define an antechamber (85), and to form a seal between the septum and a reservior (32). The septum (66) is held in compression between the annular band (68) and a guide (56) to improve resealing of the septum.

Abstract: Apparatus and method for filling, or refilling, the internal reservoir of a medication infusion system, wherein filling or refilling is permitted only when a means for injecting medication is properly positioned relative to the reservoir. Prior to filling or refilling, a pressure integrity check can be made to help assure that injected medication enters the reservoir without leakage. Additionally, flushing of a portion or all of the medication reservoir can be accomplished if desired. Medication is introduced to and is stored in the reservoir at a pressure below ambient body pressure.

Abstract: A device for effecting the delayed release of an active ingredient comprises a container and, within, a dispersible unit of ingredient, a removable closure and a electrical control circuit for removal of said closure at a designated time to release the active ingredient. Several assemblies are combined to control the administration of veterinary medicaments to ruminant animals as a specific application of the invention.

Abstract: The invention relates to "insemination guns" comprising an elongate body (1) at the front end of which is fixed an insemination tube (10) ("paillette") and within which is slidingly mounted an ejection rod for ejecting the tube, while an air supply is connected by an air flow passage to the tube (10) at the front end (5a) of the body.The problem posed is to provide such an apparatus which is easy to manipulate and simple to maintain.According to the present invention, the ejection rod (6) has at least one flat (16) cooperating with the circular section wall of the conduit (5) in which the ejection rod is mounted to define the air flow passage (17) beside the ejection rod (6) in the conduit.The invention is especially applicable to inseminating turkeys.