Abstract: A medicine dispensing device includes a single injection molded part having a body and a cover pivotally interconnected by an articulation. The body has an annular base and a cylindrical encasement. The cover has a cylindrical portion and an upper dome-shaped portion. The cover is pivotal about the articulation so as to receive the body for axial alignment of the body and the cover. The dome-shaped portion is provided with cams which during the pivoting of the cover toward the body push down a springed actuator of a primary medicine packaging received in the body and fixed in the body by fastening and locking means, thereby causing release of the medicine in the primary medicine packaging.

Abstract: The disclosed embodiment relates to an injection device that is a single patient use, disposable device containing a needle and a cartridge containing a drug or pharmaceutical product. The device is initially provided in a pre-armed configuration wherein the needle sheath maintains cantilever locking tabs on the housing in a position to the maintain the needle in a position separated from the septum of a cartridge. To arm the device, the practitioner removes the needle sheath and pushes down the plunger assembly. The cantilever locking tabs flex outwardly thereby allowing the cartridge-to-housing interface and the cartridge to move forward whereby the butt end of the needle punctures the septum of the cartridge. Additionally, the cantilever locking tabs form a stop configuration with the housing of the device. The disclosed embodiment is particularly adaptable to dental anesthetic applications, as well as other medical and veterinary applications.

Abstract: The disclosed embodiment relates to an injection device that is a single patient use, disposable device containing a needle and a cartridge containing a drug, pharmaceutical product or other injectable agent. The device is initially provided in a pre-armed state in a first engagement configuration wherein the needle is separated from the septum of a cartridge. To arm the injection device, the professional urges the device from the first engagement or pre-armed configuration to a second engagement or aimed configuration wherein the needle pierces the septum and provides a sterile fluid path to the drug, pharmaceutical product or other injectable agent contained within the cartridge. The disclosed embodiment is particularly adaptable to dental anesthetic applications, as well as other medical and veterinary applications.

Abstract: To prevent a user from accidentally pricking the user with a hollow needle when separating blood components using a syringe and a connection device. A blood component separation apparatus has three syringes and a connection device. The connection device is attached to one syringe and is inserted into other syringes. The connection device has a first member to which a base end of a hollow needle is joined and a second member which is connected to the first member in such a manner as to be able to move relative to the first member. The second member is moved back and forth between a first position where a tip of the hollow needle is accommodated and a second position where the tip of the hollow needle is exposed. The second member has elastic portions which are elastically deformed in the movement from the first position to the second position. The elastically deformed elastic portions elastically energize the second member at the second position to the first position side with respect to the first member.

Abstract: Medical device assemblies having a connection mechanism for securely connecting a hub to fluid storage containers in a luer slip relationship are described. An exemplary medical device includes a hub forming a cavity, a second indicating element disposed within the cavity that engages the hub. Additional features of the medical device include a second indicating element contoured to form a line contact with the hub. In a specific configuration, the hub includes a first indicating element attached to the hub and extending proximally into the cavity having a protrusion. In a more specific configuration, the medical device includes a fluid storage container that has an indication system for visually indicating optimal fluid-tight engagement of the hub and the fluid storage container.

Abstract: Disclosed is a drug infusion system comprising a drug infusion device having a reservoir, a window for viewing the contents of the reservoir, a cannula arranged to be deployed beneath the skin of a patient, and an actuator configured to be manually actuated to drive a medicament from the reservoir to the cannula. The system also has a cannula cover and a needle handle that holds a needle for insertion into the patient. The cannula cover and needle handle are detachably attached to the drug infusion device, and each is attachable to the other. The device further comprises a septum and a septum pincher to seal the device. The device also comprises a pumping mechanism, part of which are a last-dose lock-out mechanism and an occlusion detection mechanism, both of which operate on the same actuator.

Abstract: A portable handheld fluid-medicine-injection device for individual users, has a medicine vial has a substantially rectangular cross section that reduces a thickness profile of the device and a dispense mechanism coupled with the vial, the dispense mechanism has an inject push rod inside a threaded cylinder that reduces a length profile of the device. The device has a needle with a needle mount/dismount mechanism coupled with the medicine vial and a needle storage mechanism that stores the needle when not in use and replenishes the needle for reuse.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: The present invention is directed to a pen-type injector equipped with a cartridge holder for a drug delivery device. The cartridge holder has a longitudinal axis and comprises a body for receiving a cartridge, wherein the body comprises at a proximal end engagement means for releasably coupling the cartridge holder to the drug delivery device, a latch member for releasably engaging a cap of the drug delivery device and an alignment element which is visual from the outer side of the body. The alignment element may be an aperture provided in the body and/or a lug which forms the latch member.

Abstract: A needle tip for an injection device includes a body having a front portion, a back portion configured to be removably connected to the pre-loaded injection device, and a wall separating the front and back portions. A hollow needle has a first piercing portion projecting back from the separating wall and a second piercing portion projecting forward from the separating wall. A safety shield that is axially movable relative to the body at least between an initial position, a retracted position, and a post use locking position. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Abstract: A device for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a mechanical fastener disposed on at least one of the wings. The mechanical fastener is configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. In another embodiment, a sharp tip of a medical needle is withdrawn from a patient, a pair of wings with the medical needle positioned in between is closed, and the wings are fastened together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: A vial holder is provided to protect a user's hand from needle sticks. The holder includes a handle and a shield attached to a distal end of the handle. An opening is formed in the distal end of the handle to receive a vial. The vial is placed through the opening and into a passageway of the handle with the upper end of the vial exposed. A user grasps the handle which holds the vial in a stabilized manner. A needle may then safely approach the vial in which inadvertent slippage or movement of the needle results in contact with the needle against the shield and not contact with the user's hand.

Abstract: A device is presented for injection of a product into an injection site, comprising: a container provided with a needle, a housing receiving the container, and a needle shield releasably coupled with the container. The device also includes a retaining arrangement provided at or near the distal end of the device, designed for preventing the container from moving distally with respect to the housing until the needle shield is removed from the container.

Abstract: An injection device having a distal end, and including a needle located inside the injection device in an initial position, wherein the needle is moveable to a puncturing position in which the needle projects from the distal end, an open region located distally relative to the needle in the initial position of the needle and having a dimension, and a reduction piece moveable relative to the opening region whereby the dimension may be reduced.

Abstract: The autoinjector systems disclosed herein provide in part devices for allowing patients with reduced joint strength to more easily administer medicine. Certain exemplary syringe embodiments include a housing, a syringe assembly slidably mounted on the housing, and a needle cap releasably engaged to the housing, where the cap includes a protruding pocket for receiving a needle cap remover.

Abstract: Systems, devices, and methods are provided for providing safe syringe assemblies for injections. The syringe assemblies include a shielding mechanism that covers a syringe needle after an injection is delivered, thereby reducing the risk of a subsequent accidental stab from the needle. The shielding mechanism has a pre-injection configuration in which the needle extends beyond the housing and a post-injection configuration in which at least one component of the syringe assembly covers the needle. In some implementations, the syringe assembly includes a lock that inhibits the assembly from returning to the pre-injection configuration once an injection is delivered. The syringe assemblies may also include a bevel orientation mechanism that allows a user to align a needle bevel to accurately insert a needle for injection.

Abstract: A pen needle assembly (111) includes an outer shell (151) having a first end adapted to contact a patient's skin at an injection site. A hub (131) is movably disposed within the outer shell. A needle (121) is fixed to the movable hub and has a patient end for piercing the skin at the injection site. An inner shell (171) is disposed within the outer shell and adapted to engage the pen needle assembly with a drug delivery pen (100). A first spring (141) has a first end connected to the outer shell and a second end connected to the inner shell. A second spring (161) has a first end connected to the inner shell and a second end connected to the hub. An adhesive layer (191) is disposed on the movable hub for contacting and raising the skin at the injection site.

Abstract: Disposable items made from bioplastic resins include a biodegradable resin selected from the group consisting of polylactic acid (PLA), cellulose based PH, polycaprolate (PCL), polybutyleneadipatetetephathalate (PBT), polyhydroxyalkanoate (PHA), green polyethylene (GPE), green polyethylene terephthalate (GPET), poly-D-lactide (PDLA), and poly-L-lactide (PLLA); a plasticizer intermixed with the resin to provide a generally homogenous bioplastic; and a device formed from the bioplastic, where the device is at least one of a multidose syringe, a sharps container, or a suction canister. Embodiments include green indicators.

Abstract: The present invention relates to a shield (10) for the distal extremity of an administration device (3) comprising a hub (2) on which said shield (10) is to be removably engaged, said shield (10) having a wall (13) the internal face (14) of which defining an interior cavity (15) for receiving the extremity of the administration device (3), at least a portion (14a) of said internal face (14) being intended to be in contact with said hub (2) when said shield (10) is engaged on the extremity of said administration device (3), whereby said portion (14a) has, distributed over a major portion of said portion (14a), a surface feature (16, 17) that defines the amount of contact between said portion (14a) and said hub (2).

Abstract: A package for a medical cannula with a hub, such as a pen needle, is disclosed. The package includes a cover for receiving a medical cannula and for engaging a hub of the medical cannula. The cover has open ends that are in communication through the cover. The packaging also includes a sterility barrier for the cover.

Abstract: Medicament delivery device comprising an elongated housing (10) comprising a grip member (64) connected to the elongated housing and movable between a rest position in which the device has a predetermined grip size and an operation position in which the pre-determined grip size of the device is increased for providing an improved grip of the device during use.

Abstract: The present disclosure describes an extended finger flange that facilitate use of syringe systems. The extended finger flange increases the surface area available for an end user's fingers thereby allowing a more secure grip on the device and providing greater control during administrations of the medication.

Abstract: A Luer securement device comprising a Luer adapter having a septum and a catheter hood, the Luer adapter further having a wedge seal for receiving a base portion of a catheter. The Luer securement device further includes an inserter body in which is slidably housed a catheter threader having a probe which is configured to advance a base portion of a catheter through the septum thereby seating the base portion of the catheter into the wedge seal of the Luer adapter as a tip portion of the catheter is inserted into a patient. The catheter threader further includes a needle adapter having a needle which is threaded through the probe and the catheter to assist in inserting the catheter into the patient. Following insertion of the catheter, the catheter threader is retracted within the inserter body thereby withdrawing the needle from the catheter and shielding a sharpened tip of the needle within at least one of the inserter body and the catheter threader.

Abstract: According to the invention, an injection device (D) comprises a pre-filled syringe and a safety device. The pre-filled syringe comprises a barrel with an inner cavity in fluid communication with a hypodermic needle attached to a distal end of the pre-filled syringe and a piston fluid-tightly sealing a proximal end of the inner cavity. The safety device comprises a support body for retaining the pre-filled syringe therein, an outer body operably connected to the piston, a needle shield and a releasable retaining means (R). The retaining means comprises a radial projection and a longitudinal recess adapted to receive the radial projection. The radial projection is connected to or integral part of one of the support body or the outer body and a longitudinal recess formed into the other of the support body or the outer body. The needle shield, the support body and the outer body are telescopable relative to each other.

Abstract: The present invention provides for an injection device including a syringe with a proximal end, a distal end, a needle extending from the distal end, and a plunger inserted into the proximal end. A guard is slidable on the syringe, has a proximal end, a distal end, and is biased from a first position wherein the needle is exposed towards a second position wherein the guard covers the needle. The injection device includes first and second sets of cooperating detents for retaining the guard and syringe in the first and second positions, respectively. A latch member extends proximally from the guard that is engageable by the plunger as the plunger is depressed to release the first set of cooperating detents. Upon release, a spring element biases the guard towards the second position until the second set of cooperating detents engage and secure the guard in the second position.

Abstract: A needle tip protector is configured in such a manner that a flexible plate is provided to a protector main body over which an action ring is mounted and that the flexible plate undergoes flexural deformation when the action ring is moved to a predetermined position relative to the protector main body. When the flexible plate undergoes flexural deformation, a needle tip of an inner needle to which the protector main body is mounted is protected by a protection part placed at a distal end of the flexible plate. The needle tip protector is also provided with a slip-stop mechanism for preventing the action ring from slipping out of the protector main body in an axial direction of the needle.

Abstract: A device comprising a body, a sleeve mobile in relation to the body, and a lock enabling locking of the sleeve in a protective position; the sleeve can be moved between a non-protective position, in which an injection member is exposed, and the protective position; the lock comprising at least one flexible proximal leg. According to the invention, the at least one leg comprises at least one bearing surface and the device comprises at least one corresponding bearing surface, these respective bearing surfaces being able to bear against each other when a stress is exerted on the sleeve in a direction tending to return the sleeve toward the non-protective position.

Abstract: Formulations comprising an anti-IL-13 antibody are provided, including pharmaceutical formulations and methods of using such formulations.

Abstract: A safety device for an injection device including a protective sheath driven by a spring, the safety device being capable of taking an injection configuration in which the sheath allows an injection needle to be left uncovered, and a safe configuration in which the sheath enables the injection needle to be covered; retractable catches for retaining the spring, the retractable catches retaining the spring under stress in such a manner as to hold the safety device in the injection configuration; and deactivation mechanism for deactivating the retractable catches, enabling the safety device to take a storage configuration in which the retractable catches are not subjected to stress from the spring.

Abstract: The present invention relates to a device for removing delivery member shields which are intended to cover and protect delivery members, said device comprising a remover body arranged to accommodate a delivery member in its interior. The invention is characterised in that the remover body comprises at least two sets of gripping members extending into its interior and wherein each set of gripping members is configured for gripping a certain type of delivery member shield.

Abstract: The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human proprotein convertase subtilisin/kexin type 9 (PCSK9). The formulations may contain, in addition to an anti-PCSK9 antibody, at least one amino acid, at least one sugar, or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.

Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit has a housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity is arranged for receipt of a syringe suitable for use in the injected delivery of drug to a patient. The syringe has a barrel for containing a volume of a liquid drug formulation, the barrel defining an end flange at the rear end thereof and a forward shoulder at the forward end thereof. The cassette unit includes a sleeve form adapter arranged for receipt by the syringe barrel and to fit at least partly over the end flange of the syringe barrel. Accommodation of different syringe sizes within the same cassette unit geometry is achievable by selecting a sleeve form adapter tailored to the particular sizing of the barrel of each different syringe.

Abstract: A needle has a distal end, a proximal end, and a stem extending there between, as well as a tip at the distal end. The needle is provided with a safety device being arranged so as to be capable of sliding over the stem and a second position at the distal end of the stem. The safety device also includes a recess having a proximal opening and a distal opening for the needle stem to pass there through, the tip of the needle being inside the recess when the safety device is in the second position. The device includes a closing device that closes the distal opening of the recess when the needle tip is inside the recess.

Abstract: A device is presented for injection of a product into an injection site, comprising: a container provided with a needle, a housing receiving the container, and a needle shield releasably coupled with the container. The device also includes a retaining arrangement provided at or near the distal end of the device, designed for preventing the container from moving distally with respect to the housing until the needle shield is removed from the container.

Abstract: A safety cap for use with a needle, the cap including an opening in the cap adapted to receive a needle therein, a releasable lock mechanism disposed within the opening, and a permanent lock mechanism disposed within the opening. The safety cap may be provided on a needle, the releasable locking mechanism being actuated to release the needle from the cap. After use, the needle may be reinserted into the safety cap and permanently locked therein by the permanent locking mechanism, thereby providing for safe disposal of the used needle.

Abstract: A prefilled medical injection device with production specific elements is provided as a single use disposable injection device that is optimally suited for mass production through the Blow Fill Seal manufacturing process. The device utilizes a valve and a needle assembly fused to an insert. The valve and the needle assembly are positioned within the insert forming a conduit. The needle assembly is covered with a needle cap that is detachably coupled to protecting the needle assembly from contamination and a user from accidental needle stick. The insert is engaged to the bellows during the BFS manufacturing process and hermetically sealed by a parison layer that covers exterior portion of the insert and the needle cap. The parison layer is formed and trimmed creating exterior features that facilitate the use of the prefilled medical injection.

Abstract: An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

Abstract: A needle safety device for a medical device, in particular for an IV catheter assembly, being movably arranged on the needle comprising: a first part made of a suitable plastic material; a second part preferably made of a strip of suitable metal sheet; and a ring surrounding the first part and the second part having elastic properties made of suitable elastomeric material.

Abstract: Medical needle assemblies incorporating a needle cover are provided. According to one aspect, the needle cover is integrally formed from a material that: (1) is sufficiently rigid to prevent bending of an underlying cannula, (2) is suitable for allowing a frangible portion thereof to be broken under pre-selected conditions, and/or (3) has a moisture vapor transmission rate sufficient for steam sterilization of a needle tip enclosed by the needle cover. According to another aspect, at least part of a cap portion and a hub portion of the needle cover are translucent. According to yet another aspect, the needle cover is provided with a wing having an enlarged rib suitable for gripping during separation of a cap portion from the remainder of the needle cover.

Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A needle assembly comprises a body configured for attachment to a drug delivery device. The body defines a cavity. A septum is positioned within the cavity and a stopper positioned within the cavity such that the cavity, septum, and stopper define a reservoir. A double ended needle is positioned in the stopper and septum, the needle comprising a proximal end and a distal end. A release mechanism is positioned near a distal end of the body. A biasing element is positioned to drive the stopper. During a dose dispensing step, the release mechanism drives the proximal end of the needle out of the septum so that the proximal end resides in said reservoir. The biasing element may also drive the stopper proximally.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip positioned inside the hollow interior of the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for movement relative to the receiver and the needle to cut the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: The present invention relates to an auto injector, e.g. a disposable auto injector, that can be safely operated for automatic injection of a dose of medication by the recipient of the medication, having a housing for accommodation of a container with at least one compartment for accommodation of a medicament to be injected and a needle mounting site for user mounting of a needle covered by a needle cap before injection, and a needle shield that is accommodated in the housing in a retracted position before mounting of the needle and that is configured to be automatically moved forward to a protruded position by a needle shield driver upon mounting of the needle and removal of the needle cap.

Abstract: A medical injection device is provided which includes a shield system and a syringe. The shield system includes a housing, a shield telescopically received in the housing and slidably coupled to the housing and a driver that pushes the syringe stopper to cause drug injection. The driver is equipped with sensing elements that automatically detect empty syringe. A spring resiliently urges the shield from a retracted position to an extended position shielding the needle. The syringe is coupled to the housing. The shield is positioned externally to the syringe and the driver. The shield includes flexible latches to keep its position relative to the housing during storage and use. The axial movement of the driver in respect to the syringe causes an automatic release of the spring by sensors when the syringe is empty, allowing the spring to move and lock the shield in the extended position after use.

Abstract: A needle assembly for a medical device comprising a needle cannula which is mounted in a hub connectable to a medical device, and which needle assembly comprises releasable locking means which co-operates with the connection means of the hub such that the needle cap is locked to the hub when the releasable locking means is not released. Once the locking means is released by activation of the connection means, the needle cap is unlocked from the hub. The activation of the locking means is preferably done automatically when the needle assembly is attached to the medical device.

Abstract: A method of using a safety enclosure for a needle, the needle including an aft end and a fore end together forming a right angle, the fore end including a sharp outer end. The method includes providing a safety enclosure including a needle housing and a panel unit, the needle housing having a finger pad, orienting the safety enclosure in a desired location for insertion of the needle, and applying pressure to the finger pad sufficient to cause penetration of the needle at the desired location and to move the panel unit to the installation position.

Abstract: An apparatus for the prevention of sharps injuries, and more particularly sharps injuries caused by needle sticks, scalpel blades, hobby blades and the like, is disclosed. The apparatus comprises an instrument holder, sharps protector, passing aid, and safety transport apparatus that is simple to fabricate and inexpensive, and that accepts sharps of varying size. In particular, the apparatus will accept needles and particularly, bent needles. Further, the apparatus will hold a needle used in multiple injections and which will not dull the needle tip or contaminate the needle tip or the needle.

Abstract: An arrangement for covering the sharp point of a needle of a syringe or similar needle device. The arrangement includes a hollow cover which exposes the needle in a retracted position and covers the needle in the deployed condition. A resilient multi-section link anchored to the syringe may propel the hollow cover to the deployed position when the link or the needle device is pressed against an environmental surface. The arrangement may be integral with the needle device or may be formed as a separate component which is attachable to the needle device. An optional cap may cover the needle when the hollow cover is in the retracted position.

Abstract: Injection devices with ergonomic enhancements are disclosed. Generally, the injection devices include large oversized grips, including flanges at the base end of the device for enhanced stability. Push-type and squeeze-type devices are described, as well as manual injectors and auto-injectors. Such injection devices are useful for delivering a fluid (e.g. medication) to a patient.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.