Abstract: A syringe is provided with an inner tube which has at the tip thereof a mouth section through which liquid can enter and exit the inner tube; a bag body which is disposed inside the inner tube and is flexible and reversible; a gasket which is mounted to the tip of the inner tube; and an outer tube in which the inner tube is inserted together with the gasket so as to be movable in the axial direction. The syringe is configured in such a manner that, when liquid enters and exits through the mouth section, the bag body is reversed to change the volume of a containing space surrounded by the inner tube and the bag body.

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: Disclosed is a family of intranasal spray dispensers for administering uniform low doses of desmopressin so as to achieve safe antidiuresis in human patients. The dispensers of the invention may be used in the treatment of nocturia, primary nocturnal enuresis, incontinence, urinary frequency, diabetes insipidus, or any disease or syndrome where desmopressin therapy is useful or where safe temporary suppression of urine production may lead to beneficial health effects or increased convenience in voiding control.

Abstract: A device for administering a therapeutic substance includes a sealed package and an administration assembly. The sealed package includes a collapsible compartment containing the substance. The administration assembly includes a dispenser that is in fluid communication with the substance. At least one compression member is movable by linear actuation to progressively collapse the collapsible compartment and urge the therapeutic substance through the dispenser.

Abstract: Apparatus for use with tissue (22) of a subject, including a substance (24) configured to be injected into the tissue, and first and second tissue-squeezing surfaces (20) configured to be placed on first and second sides of the tissue, to exert pressure on the tissue by being moved toward each other in response to a squeezing force (F), and to facilitate injection of the substance into the tissue by releasing the substance in response to application of the squeezing force.

Abstract: A nasal irrigation device includes a container for storing nasal cleansing fluid, a spout having a connecting end, a nose engaging end and a spout passage, the connecting end of the spout being removably coupled to the container to allow the spout passage to receive nasal cleansing fluid from an opening of the container, the spout having a curved portion for directing nasal cleansing fluid toward a nasal passageway of a user when the container is clear of a nasal discharge path, the spout passage being continually open and unobstructed. The container is partially collapsible to force nasal cleansing fluid through the spout passage and into the nasal passageway.

Abstract: Unit-dose containers and kits for administering liquid medicament to the buccal cavity of a patient, and related methods of manufacturing such containers, are described. The containers may include a chamber, with a liquid medicament housed therein, and a squeezable region used to deploy the medicament. The container also includes sealing means to prevent premature deployment of the medicament. The container also includes an elongated dispensing tube, approximately 1 to 12 cm in length, in fluid communication with the chamber. The length of the dispensing tube may be sufficient to allow, for example, the distal end of the tube to be located within the buccal cavity of most patients, without the user's hand having to be located between the jaws of the patient.

Abstract: A method for treating a pneumostoma by applying suction to the pneumostoma in order to remove solid or liquid discharge. A pneumostoma aspirator including a bulb or syringe is used to apply negative pressure to a tube which enters the pneumostoma. The pneumostoma aspirator may be used in conjunction with a pneumostoma management device. Alternatively, the pneumostoma aspirator may be used after the pneumostoma management device has been removed. The pneumostoma aspirator may also be used to introduce irrigation fluid into the pneumostoma and/or remove irrigation fluid and discharge from the pneumostoma.

Abstract: Disclosed therein is a medicinal liquid supply apparatus, which includes a fixed-type medicinal liquid supply volume controller adapted to supply medicinal liquid only as much as a paramedic sets and fixes and an arbitrary medicinal liquid supply volume controller adapted to allow a patient or the third party to arbitrarily supply the medicinal liquid as occasion demands during the paramedic's absence, thereby effectively supplying the medicinal liquid according to the patient's disease and pain conditions.

Abstract: A pin for hygienic and/or medical use in the anal region includes a first section extending from a predetermined end of the pin in the longitudinal direction thereof, and a second section that is offset from the first section in the longitudinal direction of the pin. The first section is introduced into the anal region of a patient and the second section enables a user to hold the pin. The first section includes, on its surface, one or more receiving elements, by way of which stool remainders can be removed from the anal region and/or substances can be supplied to the anal region.

Abstract: The disposable unit dose pharmaceutical delivery system may be used by trained medical personnel for intradermal or subcutaneous injections in applications currently being serviced by conventional pre-filled syringes. The delivery system may also be used by personnel with little or no medical training for mass immunizations in underdeveloped parts of the world, insulin injections, and/or emergency epinephrine injections. The delivery system includes an envelope with a tear-away section and a dispensing section. When the tear-away section has been removed, a needle is exposed and is ready for insertion in the patient. The dispensing portion is squeezed between the thumb and forefinger to inject the pharmaceutical into the patient. The exterior surface of the envelope may be used for advertising by a pharmaceutical producer, a supplier or otherwise.

Abstract: The present invention is directed to providing a sterile package (1, 1?) integrally housing a contents-pouring device (5, 5?) which has improved contents pourability and tamper evidence. According to the present invention, the sterile package (1, 1?) can be efficiently produced by adopting the following steps of: (1) disposing a parison (27) in a mold (32) for a plastic container main body, (2) blowing sterile air from a nozzle (24) inserted in the parison (27) to blow-mold the plastic container main body, (3) filling the plastic container main body (2) with contents through the nozzle (24) and retracting the nozzle (24), (4) inserting a contents-pouring device (5, 5?) in the parison located above the plastic container main body (2), (5) clamping a mold (31) for a protective case, and (6) forming a protective case (6) with the parison located above the container main body (2).

Abstract: A nasal irrigation device includes a container for storing nasal cleansing fluid, a spout having a connecting end, a nose engaging end and a spout passage, the connecting end of the spout being removably coupled to the container to allow the spout passage to receive nasal cleansing fluid from an opening of the container, the spout having a curved portion for directing nasal cleansing fluid toward a nasal passageway of a user when the container is clear of a nasal discharge path, the spout passage being continually open and unobstructed. The container is partially collapsible to force nasal cleansing fluid through the spout passage and into the nasal passageway.

Abstract: A dispensing container fillable with a liquid includes a squeezable reservoir for holding the liquid prior to dispensing; a nipple dispensing head which is integral with the squeezable reservoir and having a distal end and a proximal end; an outlet at the distal end of the nipple dispensing head for dispensing the liquid from the container; a passage interconnecting the squeezable reservoir and the outlet; and a stop disposed near the proximal end of the nipple dispensing head to prevent over-insertion of the dispensing head into a user's mouth when the container is used to dispense the liquid to the user. Containers that are filled with liquid and a method of making the containers are also described.

Abstract: A syringe plunger/jacket assembly may comprise a flexible jacket attached to a rigid plunger. The jacket may comprise at least two sealing rings (front and rear) that prevent fluid from leaking out of the rear of the barrel during injection of fluid from the syringe. The rear sealing ring may or may not contact or seal the interior surface of the syringe barrel in an unloaded state. In the loaded state, when force is applied in the direction of the forward discharge end of the syringe, pressure is created on the jacket. This condition causes the rear seal to expand and contact and/or seal the interior surface of the syringe barrel.

Abstract: The kit for suppressing drug craving K is used by connecting an instrument for suppressing drug craving 1 to a syringe 2 and the instrument for suppressing drug craving 1 has a cylindrical housing 11, a pouch 12 provided in the housing and containing pseudo-blood B and a connecting member 13 with which the distal end of a syringe is coupled and which cause the syringe to communicate with the interior of the pouch. When the syringe accommodating pseudo-drug M is connected to the instrument and the plunger is moved forward (pseudo-priming), the pseudo-drug M flows into a pouch and the pouch inflates (FIG. 2(b)), and if the plunger 4 is pulled back from this condition, the pouch 12 deflates and the pseudo-blood B flows back from the pouch 12 to the syringe 2 (flashback) (FIG. 2(C)).

Abstract: A cartridge assembly apparatus for an auto-injector includes a flexible container containing a liquid medicant. A needle hub is connected to the flexible container. A needle is attached to the needle hub and extends proximally from the needle hub. A frame is connected to the needle hub and includes a frame proximal end extending proximally beyond a proximal end of the needle. The needle hub and the needle are displaceable relative to the frame in a proximal direction to insert the needle into a patient.

Abstract: A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen. A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.

Abstract: A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

Abstract: A method for delivering medicament such as for ameliorating pain in a patient includes introducing an injector through a nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion (SPG) of the patient; and delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the SPG. A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement.

Abstract: A dispensing container tillable with a liquid includes a squeezable reservoir for holding the liquid prior to dispensing; a substantially flat dispensing head which is integral with the squeezable reservoir and having a distal end and a proximal end; an outlet at the distal end of the dispensing head for dispensing the liquid from the container; a passage interconnecting the squeezable reservoir and the outlet; and a stop disposed near the proximal end of the dispensing head to prevent over-insertion of the dispensing head into a user's mouth when the container is used to dispense the liquid to the user. Containers that are pre-filled with liquid and a method of making the containers are also described.

Abstract: A pharmaceutical dispenser including a tube having an open end and a space filled with a composition, and an applicator including a first end removably coupled to the open end of the tube and a longitudinal portion with at least one aperture is described. The dispenser can also include a removable cover extending longitudinally and having a bore surrounding the longitudinal portion of the applicator. The composition may be an anal medication. A single dosage unit of the composition is usually contained in the tube, and the tube, applicator, and cover are disposable after use. Methods of using the dispenser include squeezing the tube, allowing the composition to exit the aperture of the applicator, and applying the composition to a target area.

Abstract: A dispensing container fillable with a liquid includes a squeezable reservoir for holding the liquid prior to dispensing; a dispensing head which appears substantially flat in profile and which is integral with the squeezable reservoir and having a distal end and a proximal end and having a bottom surface and a top surface one or both of which has an indented portion; an outlet at the distal end of the dispensing head for dispensing the liquid from the container; a passage interconnecting the squeezable reservoir and the outlet; and a stop disposed near the proximal end of the dispensing head to prevent over-insertion of the dispensing head into a user's mouth when the container is used to dispense the liquid to the user. Containers that are pre-filled with liquid and a method of making the containers are also described.

Abstract: A portable bidet includes a cylindrical member for storing washing liquid, and an airbag section connected to the cylindrical member for supplying air upon squeezing to cause injection of washing liquid. The cylindrical member is formed of hard resin and has an arcuate tip end portion and at least one ejection port. An extruding member is disposed in the cylindrical member. The ejection port is closed by a releasable film member after the washing liquid is stored. The airbag section is formed of flexible or soft resin having a sealable air inlet, and when not in use, can be collapsed and packed alongside the cylindrical member.

Abstract: A convenient pill delivery system comprising a container, a consumable substance contained in such container, and a specialized cap capable of receiving one or more pills. The consumable substance is forced out of the container onto the cap and surrounds and encompasses the pill. The consumer licks the pill and consumable substance together off the cap and swallows it. The consumable substance provides bulk and lubrication to the pill and aids the consumer in swallowing the pill quickly, easily, and efficiently.

Abstract: A bottomed conical hollow 6b is formed in a tip end of the container body A formed of a thermoplastic material with a liquid filled and sealed therein simultaneously during the molding process, the hollow having an inside diameter enlarging toward the tip end, and a small-diameter instilling hole 6c is penetrated through the bottom of the hollow 6b for controlling, at a set quantity, the liquid pushed out of the container body A.

Abstract: An aspirator, including a bulb that defines first and second ports, a tube adjacent to the first port defined by the bulb, and means for helping to prevent aspirated material inside the bulb from exiting the bulb through the second port defined by the bulb.

Abstract: A compression hypodermic syringe is disclosed wherein two leaves are hinged together. One leaf contains a receptacle for a collapsible capsule which contains a pre-measured dose of medication. The second leaf has a structure that acts as a plunger when the second leaf is folded over the first leaf. A double ended hypodermic needle is provided that has one end that pierces a membrane on the collapsible capsule and a second end that is exposed for insertion into a patient when the two leaves are folded together.

Abstract: The present invention relates to an apparatus and method for intradermally administering a pharmaceutical composition or other substance into and through the skin of a mammalian body in a manner that avoids or eliminates excess pain and discomfort normally caused as a result of the microabraders or microneedles entering the epithelial layers beneath the stratum corneum. In a preferred embodiment, the apparatus is a microdevice with an array of microabraders or microneedles with a manipulating member.

Abstract: Syringes and methods of using are described which protect the syringe barrel cavity from contaminants. A first syringe is formed with a corrugated sheath which encloses the plunger and space between the rearward end face surface of the syringe barrel handle member and the forward face of the plunger handle member. A second syringe is formed with a syringe barrel having a straight segment and a corrugated segment having the forward face of the plunger handle member molded to the rearward terminus of the corrugated segment of the syringe barrel. A third syringe is formed from mating syringe barrel and plunger member walls. The walls of the mating syringe barrel and plunger member are concentric and slide relative to each other while maintaining an enclosure around the plunger shaft. A fourth syringe is formed from inner and outer concentric syringe barrel walls mating with the walls of a plunger member.

Abstract: For safely inserting a catheter into a chest cavity of a child or corpulent patient to be retained therein and for preventing atmospheric air from proceeding into the chest cavity during a removal of a penetrating needle, discharge equipment for medical procedures is provided which equipment includes a connector cap and a storage bottle detachably connectable to each other, a connector to be connected to the catheter retained in the patient, a check valve including an outer periphery covered by a protective cover and being openable only toward a storage bottle side, and a coupling device to the storage bottle mounted on the connector cap. The storage bottle is a hollow container including an inlet port and a discharge port, a detachably connecting device for the connector cap mounted on the inlet port, and a check valve openable only toward an exterior of the storage bottle is mounted on the discharge port.

Abstract: Syringes and methods of using are described which protect the syringe barrel cavity from contaminants. A first syringe is formed with a corrugated sheath or non-corrugated sheath which is positioned internal or external to the syringe barrel cavity. A second syringe is formed with a syringe barrel having a straight segment and a corrugated segment having the forward face of the plunger handle member molded to the rearward terminus of the corrugated segment of the syringe barrel. A third syringe is formed from mating syringe barrel and plunger member walls. The walls of the mating syringe barrel and plunger member are concentric and slide relative to each other while maintaining an enclosure around the plunger shaft. A fourth syringe is formed from inner and outer concentric syringe barrel walls mating with the walls of a plunger member. The mating walls are concentric and slide relative to each other while maintaining an enclosure around the plunger shaft.

Abstract: A multiple-dose syringe including a barrel with a closed end and an open end, the closed end having an injection port that may be adapted to receive a needle, or that may be adapted to engage a commercially available needle-less system for fluidly connecting a syringe to an IV or a medicine vial. A plunger is slidably disposed through the open end of the barrel. A container is connected to an end of the plunger to move with the plunger. The container has a deformable shell with an opening at a forward end thereof and a predetermined quantity of fluid sealed therein by a closure member disposed over the opening to selectively seal the opening. The closure member includes a valve that opens in response to a fluid pressure differential across the valve.

Abstract: In an eye drops container, a barrel portion 2 in the form of a flexible hollow cylinder defines a dent portion 7 which can be gripped with two fingers.

Abstract: Flexible impervious bag for medical use containing a pharmaceutical preparation of liquid oxaliplatinum said flexible bag is constructed from plastic materials, with the proviso that any portion to the bag in direct contact with said pharmaceutical preparation of liquid oxaliplatinum does not contain polyvinylchloride-based plastic material.

Abstract: A new and improved anesthetic delivery tool and method of using the tool in transmucosal absorption applications of a gel topical anesthetic agent and in subdermal injections of a liquid anesthetic agent is disclosed. The anesthetic delivery tool comprises a housing unit having a hollow central cavity with a slip plate containing a plurality of needles directed towards the front end of the housing unit. The slip plate and the front portion of the hollow central cavity defining a front-end cavity for affixing a therapeutically effective aliquot of gel topical anesthetic agent. The anesthetic delivery tool also comprises a thin membrane positioned directly behind the slip plane and a push plate positioned at the rear end of the housing unit. The push plate, the thin membrane and the rear portion of the hollow central cavity defining a rear-end cavity for affixing a therapeutically effective amount of liquid anesthetic agent.

Abstract: A drug dispensing system for substantially preventing addictive use of drugs. The system has multiple dispensers each containing a drug such as nasal spray. The drug in at least one of the dispensers is diluted to a first pre-selected concentration level with a diluent and the drug in at least a second one of the dispensers is diluted to a second lower pre-selected concentration level with a diluent.

Abstract: A method and related device for performing sterile medical procedures are disclosed. The method and related device are capable of accessing a sterile environment from a non-sterile environment to perform a medical procedure within the sterile environment. The method and related device can achieve a sterile technique during endoluminal procedures and in uncontrolled and unsterile environments. The device includes an inner hollow member moveably disposed within an outer hollow member. The outer hollow member is adapted to penetrate a boundary separating non-sterile and sterile environments and the inner hollow member is adapted to extend past the outer hollow member and into the sterile environment. A fluid compartment is adapted to be in selective fluid communication with the outer tube such that when the inner member extends past the outer member and into the sterile environment, fluid enters the outer member and the boundary.

Abstract: A syringe having a breech and a slot adjacent an ampule chamber adapted to receive the body and nozzle of a collapsible ampule. A syringe includes a forward ampule chamber having a predetermined longitudinal length for dispensing a relatively low viscosity material. A closed ampule containing a relatively low viscous material is collapsible and is easily positioned and held within the syringe during dispensing. The nozzle slot permits easy insertion of the flexible collapsible ampule and removal once the ampule is collapsed. In one embodiment, a syringe barrel has flexible fingers used in combination with a plunger having a reduced diameter intermediate portion for preventing the plunger from falling out of the barrel. Low viscosity materials in a unit dose collapsible ampule are controllably and conveniently dispensed for use in many different applications. The present invention is particularly suitable for dispensing dental materials.

Abstract: A syringe system (20) includes an elongated shell (30), a pressure member (80) slidable disposed within the elongated shell (30), and a collapsible cartridge (100). The Collapsible cartridge (100) is inserted within the elongated shell (30), and collapses as the pressure member (30) is advanced within the elongated body (30) to pressurize fluid within the collapsible cartridge (100). The collapsible cartridge (100) preferably further includes a passage (130) through which the fluid passes when pressurized by the pressure member (80).

Abstract: This invention relates to an improved syringe designed for effecting complete transfer of contents retained within the syringe. The improved syringe contains a rupturable fluid-filled bladder that is retained within the chamber of the syringe. When ruptured the bladder discharges the fluid retained therein and washes the interior of the chamber and component parts.

Abstract: Disclosed is a single-use syringe comprising a needle housing, a bore-containing fluid-delivery needle and a volume-containing element. The needle housing has a top surface to which the volume-containing element is attached, a needle attachment side to which the bore-containing needle is attached, and a fluid delivery channel in communication between the top surface and the needle attachment side. The volume-containing element is fluid-tight but for communication with the fluid-delivery and a filling port. Embodiments are disclosed which include vapor-permeable portions which facilitate lyophilization of materials in situ.

Abstract: An implantable microbolus infusion pump is disclosed which includes an elastically deformable reservoir, an electrically activated microvalve, and a remotely activated control system. The control system includes a sensor that can be remotely activate, for example, magnetically or by infrared light. The pump can provide bolus infusion of pharmacologic agents. The pump is also capable of providing sequential release of a plurality of drugs.

Abstract: An automated injection device for administration of one or more liquid medicaments that is particularly useful for self-administration of liquid medicaments such as those used to treat anaphylactic shock, heart attack, exposure to toxic agents, or other conditions may include a number of features designed to reduce both the size and complexity of the device. With reduced size, the device may provide greater convenience and portability. Importantly, the reduced size may encourage more users to carry the device, and thereby reduce the risks associated with the conditions mentioned above. With reduced complexity, the device can be constructed at a lower cost. Moreover, the device can be more reliable and simple to operate.

Abstract: An epidural space locating device for locating an epidural space, the device comprising a body section having a first end and a second end and a longitudinal passageway extending therethrough, the first end of which is coupleable to a luer assembly; and a collapsible bellows chamber having one end coupled to the second end of the body section and the other end exposed so as to permit pressure to be exerted thereon by one or more digits of a hand, wherein positive pressure within the bellows chamber maintains the integrity of the shape of the bellows chamber and wherein negative or zero pressure within the bellows chamber facilitates the collapsing of the shape of the bellows chamber thus indicating the locating of the epidural space by a needle that is coupled to the luer assembly; wherein the loss of pressure within the bellows chamber is sensed by the one or more digits of the hand as the shape of the bellows chamber collapses.

Abstract: A catheter flushing device includes a chamber covered with a movable member (e.g., a flexible diaphragm) that can be compressed by exertion of pressure on the diaphragm; and a valve having a first position allowing fluid from a fluid source to fill the chamber, and a second position allowing fluid from the chamber to flow through the catheter when pressure is exerted on the movable member. In particular, the catheter flushing device includes a housing having a cylindrical valve opening, an inlet port for connection with the fluid source, and an outlet port for connection with the catheter. The chamber is defined by a flexible diaphragm sealed about a region of the housing. The chamber can be compressed by manually exerting pressure on the diaphragm by means of a thumb or finger. A passageway extends through the housing from the chamber to the valve opening.

Abstract: A method and related device for performing sterile medical procedures are disclosed. The method and related device are capable of accessing a sterile environment from a non-sterile environment to perform a medical procedure within the sterile environment. The method and related device can achieve a sterile technique during endoluminal procedures and in uncontrolled and unsterile environments. The device includes an inner hollow member moveably disposed within an outer hollow member. The outer hollow member is adapted to penetrate a boundary separating non-sterile and sterile environments and the inner hollow member is adapted to extend past the outer hollow member and into the sterile environment. A fluid compartment is adapted to be in selective fluid communication with the outer tube such that when the inner member extends past the outer member and into the sterile environment, fluid enters the outer member and the boundary.

Abstract: A fluid-delivery apparatus for delivering a medicament to a patient is provided in accordance with the present invention. The apparatus includes a housing defining a passageway, a bellowed ampoule positioned to lie in the passageway of the housing, and a piston. The bellowed ampoule includes a body with first and second ends and is formed to define a cavity configured to contain the medicament. The piston presses the second end of the ampoule toward the first end to dispense the medicament from the cavity. In addition, the fluid-delivery apparatus includes a visible non-linear scale that represents the relationship between a volume of medicament delivered from the first end of the ampoule and a distance that the piston has traveled in the housing toward the first end.

Abstract: A multiple-dose syringe including a barrel with a closed end and an open end, the closed end having an injection port adapted to receive a needle. A plunger is slidably disposed through the open end of the barrel. A container is connected to an end of the plunger to move with the plunger. The container has a deformable shell with an opening at a forward end thereof and a predetermined quantity of fluid sealed therein by a closure member disposed over the opening. The container is slidably disposed in the barrel and includes a seal proximal to the forward end to form a first cavity in the barrel with a volume that is adjustable by moving the container in the barrel with the plunger so that fluid can be selectively drawn into and expelled from the first cavity. After at least a substantial portion of the fluid is expelled from the first cavity, the shell is configured to be collapsed by further pressure applied by the plunger to expel the predetermined quantity of fluid contained therein.

Abstract: The invention described herein provides for methods and devices for treating tissues, and in particular, ischemic heart tissue. Preferred devices includes tools integrating both injury and treatment effectors in a single unit. An optional third effector provides an effector for marking locations on a tissue surface that have been visited by the device. Methods are provided in which a target tissue is identified, injury sites are created at known locations, and therapeutic-substance is infused at known locations different than the injury sites.