Abstract: The present application relates to pressure sensors for injection devices. According to a first aspect, the specification discloses an injection device comprising: a medicament container comprising medicament container walls and a sealing element; a stopper translatably disposed inside the medicament container; a pressure sensor; and a plunger passing through an axial bore of the sealing element, the plunger being operable to displace the stopper, wherein the sealing element, stopper and medicament container walls define a cavity inside the medicament container; and wherein the pressure sensor is configured to measure the pressure inside the cavity during an injection.

Abstract: A system for controlling the flow of fluid through a medical device may include a medical device having a lumen that extends to a distal end of the medical device; a fluid source configured to supply fluid having a positive pressure to the lumen of the medical device; and a flow controller configured to apply a negative pressure to the fluid within the lumen, wherein the flow controller is triggered to apply the negative pressure upon a lowering of the positive pressure from the fluid source.

Abstract: An access device for placing a medical article within a body space includes a syringe, a needle, and a sheath which are employed together with a guide wire. The sheath can be coaxially and slideably disposed about the needle. During insertion of the sheath over the needle, guide wire and into the body space, the syringe provides a negative pressure to ensure that any air located between the inside diameter of the sheath and the outside diameter of the needle is drawn into the needle rather than into the body space. In certain embodiments, a dilator is coaxially and slideably disposed about the needle and within the sheath.

Abstract: A device having a sheath, a medical device, a stylet, a handle having a chamber portion and a plunger device. The handle connects to proximal ends of the sheath, the medical device, and the stylet. The chamber portion includes a volume of space configured to volumetrically connect to at a lumen of the medical device, the sheath or the stylet. The plunger device slides and moves within the chamber portion. The plunger device is able to pneumatically or hydraulically isolate a proximal portion of the volume of space from a distal portion of the volume of space. Proximal movement of the stylet and the plunger device cause a suction effect (i.e., negative or reduced pressure) at the distal end of the sheath and/or the medical device.

Abstract: A fluid sample extraction device is disclosed comprising a housing defining an internal fluid passage having a distal open end and a proximal open end and a porous medium within the fluid passage, between the distal open end and proximal open end. The porous medium, which may be glass, is configured to allow fluid flow in the fluid passage to flow around the porous medium, toward the proximal open end of the housing, when fluid is drawn from the distal open end toward the proximal open end, and to allow fluid in the fluid passage to flow toward the distal open end of the housing, through the porous medium when the fluid is forced toward the distal open end. The porous medium is also configured to capture nucleic acids in the porous medium from the fluid when fluid is forced through the porous medium. Devices and kits are also disclosed.

Abstract: An exemplary syringe adapter for coupling with a syringe may include a housing. A needle-free connector may be disposed in the housing. A communication member may be in slidable engagement with the housing. The communication member may be slidable, with respect to the housing, between an unactuated state and an actuated state of the syringe adapter. A cannula may extend from the communication. In the unactuated state, the cannula may be retracted within the needle-free connector. In the actuated state, the cannula may protrude through and axially beyond the needle-free connector.

Abstract: A telescoping syringe suitable for use with medications and other materials is presented. The telescoping syringe includes a valve, a plunger, and a barrel. The valve further includes a barrier, an outlet(s) through the barrier, and an annular extension extending from the barrier. The plunger further includes an inlet(s) and a first side wall with a proximal wall. The barrel includes a second side wall with a distal wall at one end and an open end at another end. The plunger is extendable from and retractable into the barrel at the open end via slidable engagement between first and second walls. The valve directly contacts one end of the first wall so that an annular flange slidingly engages an annular groove. The valve and the barrel slidingly contact the plunger so as to open and to close the inlet(s) and/or the outlet(s).

Abstract: A pump controllably moves a small quantity of fluid from a fluid chamber to an outlet port with a small inexpensive actuator powered for a very short amount of time, thereby optimizing cost, size, and battery efficiency. Multiple pumps can be housed in a single enclosure, allowing multiple drugs to each be injected through a single cannula or needle.

Abstract: A fluid sample extraction device is disclosed comprising a housing defining an internal fluid passage having a distal open end and a proximal open end and a porous medium within the fluid passage, between the distal open end and proximal open end. The porous medium, which may be glass, is configured to allow fluid flow in the fluid passage to flow around the porous medium, toward the proximal open end of the housing, when fluid is drawn from the distal open end toward the proximal open end, and to allow fluid in the fluid passage to flow toward the distal open end of the housing, through the porous medium when the fluid is forced toward the distal open end. The porous medium is also configured to capture nucleic acids in the porous medium from the fluid when fluid is forced through the porous medium. Devices and kits are also disclosed.

Abstract: One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the composition is applied; means to selectively remove at least some of the composition from the skin surface after application of the means to vibrate, while leaving the metallic nanoparticles in proximity to or within the sebaceous gland; and means to optically irradiate the skin to which the composition was applied with light energy after removal of at least some of the composition from the skin surface.

Abstract: A medical/surgical waste collection rover includes a first waste container disposed on a portable cart and receiving waste under the influence of a vacuum. A fluid measuring system includes a float element disposed within the first waste container, and a controller causing liquid in a reservoir disposed on the cart to prefill the first waste container and subject the float element to an initial lifting to a zero point level. The fluid measuring system determines a volume of contents within the first waste container based on a position of the float element relative to the zero point level. The fluid measuring system may include a sensor rod extending through the first waste container and a second waste container disposed on the cart and separated from the first waste container by a transfer valve. Methods of estimating the volume of liquid and/or medical/surgical waste within the waste container are also provided.

Abstract: Drug delivery devices having integrated non-luer connectors are described. An exemplary drug delivery device includes a container with a non-luer connector that prevents connection of a standard female luer connector to the container. One or more embodiments pertain to a container with a non-luer connector that prevents the formation of a fluid-tight seal between a standard female luer connector and the container. A non-luer connector for attachment to a container having a non-luer element is also described.

Abstract: One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.

Abstract: Exemplary embodiments provide subcutaneous implantation tools and methods of implanting a subcutaneous micro-device using the same. Exemplary embodiments provide subcutaneous implantation tools including a syringe body, a dissection body, and a delivery assembly. Additional exemplary embodiments provide methods of implanting a subcutaneous micro-device, including inserting the dissection body of the tool described by the exemplary embodiments into an implantation site, where the dissection body includes a micro-device, and delivering the micro-device.

Abstract: A device, a system employing the device, and method of performing skin treatment are provided for skin treatment. The device includes a vacuum head base defining a chamber therein and having a substantially smooth treatment tip attached and extending from an end thereof or integral therewith. The tip has at least one central opening that is open to the chamber, and is adapted to contact the skin and traverse the skin in a substantially nonabrasive manner. A vacuum access opening is provided through a side wall of the vacuum head base and adapted to connect with a source of vacuum. A tissue stop member is located within the chamber. It may have an abrasive surface for exfoliating skin cells, or a smooth surface for traversing the skin without substantial abrasion.

Abstract: A surgical fluid manager includes a pump releasably engageable to tubing and a user interface. The user interface is configured to enable finger-touch selection of a fluid flow rate through the tubing and configured to operate in at least one of a first mode or a second mode. In the first mode, the flow rate is controlled via direct selection of one of a plurality of selectable digital numeric values, while in the second mode the flow rate is controlled via user selection of one alphanumeric identifier within a scale of alphanumeric identifiers. Each respective alphanumeric identifier directly corresponds to just one instrument size within a scale of instrument sizes.

Abstract: Featured is a vascular access device such as an IV catheter device including a housing, a tubular member and a seal member, and a securing mechanism. The housing includes a proximal and distal portion and a chamber that extends between the proximal and distal portions. The tubular member is coupled to the housing distal portion so it is fluidly coupled to the chamber. The seal member is disposed within the chamber and the securing mechanism secures the seal member distal end to the housing proximal portion so the seal member is sealingly and compressibly retained between a chamber proximal end and the securing mechanism. Such a seal member also is constituted so a portion of the seal member moves axially responsive to an axial force applied to the proximal end.

Abstract: The invention intends to provide a cell culture shaking device which is able to improve the efficiency of cell culture while preventing the cells from becoming damaged. The shaking devices used in cell culture apparatuses for culturing cells in flexible culture bags for storing culture suspension having cells inoculated therein includes: shaking mechanisms having operating panels for pressing the culture bags repeatedly, so that the culture suspension in the culture bags is stirred by being pressed by a plurality of projections projecting for the operating panels.

Abstract: Some embodiments relate to a luer connector comprising a housing having a hollow bore therethrough, a first end, and a second end, a male luer tip supported by the housing configured to rotate with respect to the housing, the luer tip having a first open end and a passageway through the luer tip in fluid communication with the first open end, and a substantially rigid internal member extending into the passageway of the luer tip toward the first open end of the luer tip. In some embodiments, at least one of the luer tip and the internal member can be axially moveable between a first closed position and a second open position relative to the other of the luer tip and the internal member. Further, the luer tip and the internal member can cooperate such that rotation of the luer tip in a first direction relative to the housing increases an axial displacement between the first open end of the luer tip and an end portion of the internal member.

Abstract: Apparatus and methods for providing a field environment filled proximal chamber of a multi-chamber syringe and for filling a prime-free syringe are disclosed. In addition, methods for resetting valves of a multi-chamber syringe without special tools or insertion of foreign objects into the syringe are disclosed. A valve for interfacing with syringes telescopically inserted into a larger syringe and which are generally used as proximal chambers in multi-chamber syringes used in mixing and serial delivery applications is disclosed. Four embodiments of novel resettable valves are disclosed. Also, a syringe assembly for delivering a saline-dose-saline medication sequence is disclosed.

Abstract: Described herein are syringe devices, systems and methods. In general, the syringe may include a first chamber and a cartridge movable within the first chamber. The cartridge may include a cartridge chamber and a valve in fluid communication with the cartridge chamber and the first chamber and having an open configuration and a closed configuration. The valve may allow movement of a liquid out of the cartridge chamber while in a open configuration. The cartridge may also include a second end, movable within the cartridge chamber, and a locking mechanism having a locked configuration and an unlocked configuration, the locking mechanism preventing movement of the second end within the cartridge chamber while in the locked configuration.

Abstract: A one-way valve (1) comprises a seat (5) and a membrane (4) having an inner portion (4a) that is stretched over the seat, wherein, in use, the inner membrane portion is selectively deflected from the seat such that a fluid path is created from one side of the membrane to the other so as to open the valve, and wherein an outer peripheral portion (4b) of the membrane is stiffer than the inner portion such that the membrane deflection is substantially restricted to only the inner portion. The one-way valve may be used in a pump for an infusion system.

Abstract: A hemostatic valve device for use in inserting an interventional device into a body lumen of patient is provided. The valve device includes a housing that defines a cavity between first and second end openings. A valve structure is disposed within the cavity, and defines a variable diameter channel for receiving the interventional device. The valve structure can include discrete layers of material, such as a sealing layer and a contractible layer such as a biaxial braided layer. The end of the valve structure is movable relative to the fixed end so that the longitudinal passageway of the valve structure varies in diameter and axial length to form a seal against an interventional device inserted within the passageway. An operable element is coupled to the movable end and is actuated by the end user to open and close the valve structure.

Abstract: A multi-utility surgical instrument may include a nosecone, a handle, a housing sleeve, an actuation facilitating sleeve, a piston tube, a hypodermic tube, and an end plug. The hypodermic tube may be disposed within the piston tube; the piston tube may be disposed within the actuation facilitating sleeve; the actuation facilitating sleeve may be disposed within the housing sleeve; the end plug may be disposed within a portion of the housing sleeve; the housing sleeve and the end plug may be disposed within the handle; the nose cone may be fixed to a distal end of the handle; and the hypodermic tube may be fixed to the nosecone.

Abstract: A medical valve includes a housing having an interior forming an inlet and an outlet. A longitudinally movable member is secured within the interior of the housing. External to the movable member and within the interior is a fluid path. Movement of the movable member controls fluid flow between the inlet and the outlet via the fluid path. The outlet produces no greater than a negligible drawback or positive push during withdrawal of a nozzle.

Abstract: A valve assembly is provided which includes a housing having an inlet end and an outlet end and defining a fluid channel and a central chamber. A dissolvable valve member is positioned to obstruct flow through the channel within the chamber. The dissolvable valve member is formed of a material which is dissolvable at a predetermined rate upon contact with a preselected fluid. The preselected fluid is selected from the group consisting of blood, urine, saline and antimicrobial solutions. The dissolvable valve member can be formed from a fluid soluble glass or a starch based material.

Abstract: A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).

Abstract: A discharge apparatus for discharging a product having compressed gas support comprises a container (1) having a discharge opening (12) and a pressure element (2), which is mounted displaceably in the container (1). A counterpressure element (13) is provided on the container (1) and is used to advance the pressure element (2) into the container in order to absorb a developing counterpressure when pressure is applied onto the pressure element (2). A compressed gas device (5, 7, 8) dispenses compressed gas in the region of the discharge opening (12), and comprises a valve (6) and a valve actuating device (14) to control the compressed gas dispensing. The actuating device (14) is provided on the counterpressure element (13) to ensure that when discharging the product from the container, at the same time the compressed gas device can be actuated by applying pressure onto the pressure element, whereby compressed gas exits the discharge opening at the same time as the fluid product.

Abstract: A piston configured to be received within a syringe is disclosed. The piston includes a valve body defining a proximal end and a distal end, a filter disposed within the proximal end of the valve body, and a valve disk disposed within the distal end of the valve body. As the piston is advanced through the syringe, the valve disk is configured to provide fluid flow through the valve body.

Abstract: Bent syringes, mounting systems for bent syringes, and devices incorporating bent syringes are described herein. The syringes include a bent cylindrical body bent about a radius and a plunger bent about the radius of the bent cylindrical body and configured and arranged to be received by the proximal open end of the bent cylindrical body and movably disposed within at least a portion of the bent cylindrical body.

Abstract: A medical instrument includes a housing with a passage through which a catheter is received. A valve body is mounted in the passage, and, as the catheter penetrates through the valve body, the valve body conforms to the outer wall of the catheter to maintain a fluid tight seal between the valve body and the catheter. When the valve body is unstressed before being mounted in the passage, the valve body has a first planar dimension and a second planar dimension that is less than the first planar dimension.

Abstract: A needleless connector has a housing with an internal cavity having an interior surface, a port, an output flow channel, and a fluid flow path through the cavity between the port and the output flow channel. A collapsible valve is disposed within the cavity. The valve has one or more rings each having a surface that is in sealing contact with the interior surface of the housing. There are one or more notches formed in each of the one or more rings, and the flow path passes through one of the notches in each of the one or more rings.

Abstract: The present invention relates to a multi-way valve for use in medicine or medical technology, having at least one basic housing through which a medium can flow in sections, and having an actuator which is held in said basic housing so as to be rotatable about a central axis, wherein the basic housing has at least two connection points for the inflow and outflow of the medium and forms an actuator receptacle which has a peg arranged concentrically with respect to the central axis and which has, on the inner side of the basic housing, a radially encircling cutout, and wherein the actuator has a control element, a substantially hollow cylindrical section which receives the peg of the actuator receptacle at least in sections, at least one throughflow opening for the fluidic connection between two connection points, and at least one radially encircling molding on the outer side of the cylindrical section, and wherein the peg of the actuator receptacle has at least one counterbearing for the actuator to form a seal

Abstract: A syringe device includes a syringe barrel and piston having a fluid passageway extending from a vial port. Another syringe device includes a syringe barrel, a piston sleeve and an insert. A channel extends along a side of the insert. A valve controls fluid communication between the channel and the syringe barrel. Another syringe device has a syringe barrel, a piston sleeve and an insert. A valve controls fluid communication between a compartment within the insert and the syringe barrel. A method of preparing a medication includes providing a component within a syringe barrel and another component within a compartment of a piston insert. A seal is over-molded onto a tip of the insert and an end of a piston sleeve. The sleeve is rotated relative to the insert to establish fluid communication between the compartment and the barrel chamber.

Abstract: Described is a catheter patency maintenance device comprising of a flush syringe, an elongate plunger rod with a stopper slidably positioned within the barrel, a cap, disinfectant and a valve movable between an open position and a closed position. The valve may include a valve stem and/or openings in the valve to permit fluid flow. Methods of using the flush syringe assemblies are also described.

Abstract: Syringe (1) including a cylinder (2) and a piston (4), in which the outlet end (6) of the cylinder (2) is integrated with a valve male luer lock connector (7).

Abstract: Some embodiments relate to a luer connector comprising a housing having a hollow bore therethrough, a first end, and a second end, a male luer tip supported by the housing configured to rotate with respect to the housing, the luer tip having a first open end and a passageway through the luer tip in fluid communication with the first open end, and a substantially rigid internal member extending into the passageway of the luer tip toward the first open end of the luer tip. In some embodiments, at least one of the luer tip and the internal member can be axially moveable between a first closed position and a second open position relative to the other of the luer tip and the internal member. Further, the luer tip and the internal member can cooperate such that rotation of the luer tip in a first direction relative to the housing increases an axial displacement between the first open end of the luer tip and an end portion of the internal member.

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a collection vessel by a flexible conduit. The collection vessel can comprise an impermeable or permeable collection vessel. The collection vessel is contained within a collection container, and can feature a tapered end. An air inlet may be provided in the flexible conduit and/or in a collection canister lid.

Abstract: Systems and methods for infusion of fluids using stored potential energy and a variable flow resistor. In one aspect of the present disclosure, there is provided an infusion device that includes a plunger situated within a vessel so as to define a chamber within which a volume of fluid can be accommodated between a downstream surface of the plunger and the vessel. The infusion device further includes an outflow path through which the fluid in the chamber can be dispensed upon displacement of the plunger by a force acting thereon. A variable flow resistor is situated within the outflow path and is configured to allow a substantially constant fluid flow rate from the vessel to be maintained as the force acting on the plunger decreases.

Abstract: A capping device is configured to terminate a connector while disconnected from another connector in a fluid transportation system, e.g., for peritoneal dialysis. The connector comprises an exposed surface portion that is enclosed when the connector is connected to the other connector. The capping device comprises a body defining a chamber with an opening, a liquid-containing disinfectant in the chamber, a sealing element arranged in the opening to form a sealed cavity retaining the disinfectant, and a structure for engaging and guiding the connector towards the body such that a portion of the connector displaces the sealing element into the chamber. The sealed cavity is configured such that a displacement of the sealing element into the chamber actively presses the disinfectant out of the sealed cavity, for disinfecting at least part of the exposed surface portion.

Abstract: The invention relates to a syringe, particularly an anesthetic syringe, having a longitudinally displaceable feeding piston disposed over a first hydraulic chamber, and a second hydraulic chamber, wherein the first and second hydraulic chambers are connected by means of a first control element for regulating resistance, wherein the first control element can be actuated by a switch element, wherein the first control element comprises a first check valve.

Abstract: An apparatus capable of cleaning a material includes pipes arranged in a first barrel; and through holes defined in a second barrel. The second barrel is received in the first barrel. The apparatus further includes a driver comprising a drive shaft, the drive shaft extending through the first barrel and being connected to the second barrel. A fluid container is included store fluid, an air controller is provided air-dry the material. Before washing the material, the second barrel is driven by the driver to cause each of the through holes to disengage from a corresponding pipe. After washing the material, the second barrel is driven by the driver to cause each of the through holes to engage with the corresponding pipe.

Abstract: Disclosed herein is a syringe comprising a syringe body with plunger and a multi-pronged actuator. The syringe can further include a male coupling member, an outer sheath, a valve member and a back plate.

Abstract: A vascular access device within an external environment may include a body and a septum at least partially housed within the body, a gas chamber housed within the body and the septum, and a vent adjacent the body capable of facilitating gas transfer between the gas chamber and the external environment. A method of venting a gas chamber within a medical device includes transferring gas between the gas chamber and an external environment of the device through a vent that is adjacent the body of the device.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A clip receives a barrel of the syringe. The clip includes a receptacle portion receiving a pre-filled cannister of a topical numbing agent, wherein the cannister includes a generally cylindrical chamber portion receivable within the receptacle portion of the clip and a distal neck portion having an outlet allowing contents of the cannister to be dispensed. A dispenser attached to the distal neck portion of the cannister includes an elongated flexible tube surrounded by a rigid tube for at least a portion of a length of the elongated flexible tube. A pivotable lever carries a tube compressor including a pinching member extending through an opening in the rigid tube and spring biased to a position at which the pinching member pinches closed an elongated passageway through the flexible tube.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A pair of clips receive a barrel of the syringe. The clips are on a housing receiving a pre-filled cannister of a topical numbing agent and including a chamber. The cannister includes an aerosol dispensing valve actuated by a button which when pressed moves the cannister with respect to an actuator for the valve.

Abstract: Syringe assemblies are provided that can include a valve within a plunger having a fluid channel extending longitudinally therethrough and along the channel, the valve including a piston extending substantially normally to the channel and configured to slidably engage the plunger along the extension. Syringe assemblies can also include: a syringe barrel having a first cross sectional diameter; a syringe piston configured to operatively couple with the barrel; a fluid channel extending the length of the piston; a vial port extending from an end of the piston, the vial port having a second cross sectional diameter, the second diameter being greater than the first diameter. Methods for controlling fluid along a fluid channel within a syringe plunger are also provided. The methods can include extending a piston in one direction normally to the fluid channel to provide fluid communication between two sections of the fluid channel.

Abstract: A dispensing device for dispensing medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.

Abstract: The present disclosure provides a cannula useful for introducing a thermally responsive polymer in situ. In embodiments, the cannula possesses more than one cannula, with the thermally responsive polymer introduced in one cannula, and a material such as a coolant in a second cannula which prevents premature gelling of the thermally responsive polymer.

Abstract: Embodiments of the invention relate to a multi-syringe device where a coupling element causes a plurality of plungers to slide in unison within their respective barrels to simultaneously dispense fluids therefrom. At least one of the plungers is a variable-length plunger that is selectively engagable to the coupling element.