Abstract: An injection device is described. The injection device includes a stopper having a first conductive element, a barrel having a medicament reservoir sealed at a proximal end with the stopper, and a plunger rod having a second conductive element. The plunger rod is coupled with the stopper to cause forward axial movement of the stopper to expel a medicament from the medicament reservoir. The first conductive element and the second conductive element complete an electrical circuit when the plunger rod is coupled to the stopper.

Abstract: A bone cement mixing and dispensing system and method for mixing and delivering bone cement therefrom. The system has a mixing container for holding a bone cement mixture, the mixing container extending along an axial length and having opposed first and second ends, the first end comprising a downstream opening for dispensing the bone cement downstream from the mixing container; a mixing element movably disposed within the mixing container; and a plunger comprising a piston movably disposed within the mixing container. In this system. with a first coupling, the mixing element moves by assistance of a motor along the axial length of the mixing container without translation of the plunger to mix the bone cement. In this system. with a second coupling, the mixing element and plunger are driven together along the axial length of the mixing container.

Abstract: A method of manufacturing a cartridge is described. An injection needle is inserted into a mold that forms a barrel. The barrel defines an open proximal end, an opposing distal end, an internal reservoir therebetween, and an arm projecting distally from the distal end of the barrel and having a portion bent at a fixed angle. The injection needle is positioned within a portion of the mold configured to form the arm of the barrel, and a terminal needle tip is oriented such that a beveled opening of the needle tip is distally facing. The injection needle is stabilized against movement with a gripping device. The mold is filled with resin to form the barrel around the injection needle. The gripping device is separated from the injection needle upon hardening of the resin.

Abstract: A medical container including a tubular barrel defining a reservoir for a medical product. The barrel is provided with a scale having graduations indicative of an injected volume or a remaining volume of said medical product. The barrel further includes a RFID tag including an antenna that forms, follows or overlays with at least a portion of the scale.

Abstract: A fluid displacement and pressurizing device which includes a housing, a first piston in the housing, a plunger which extends from the housing and has a second piston thereon, and an actuator that works to selectively lock the piston to either the housing or the plunger depending on the position of the second piston in the housing. Effectively, the actuator includes a first locking mechanism that locks and unlocks the first piston relative to the housing and a second locking mechanism that locks and unlocks the plunger relative to the piston. As such, the first locking mechanism is not only a locking mechanism but is also an actuating mechanism with regard to actuating the second locking mechanism.

Abstract: A dual chamber syringe, comprising a syringe barrel having a forward end, a rearward end and at least one bypass protrusion arranged along the longitudinal extent of the syringe barrel; a finger grip element coupled to the rearward end of the syringe barrel, the finger grip comprises at least one protrusion extending radially inwardly from an inner surface thereof; a plunger rod operatively coupled with the finger grip element; a guiding track is formed on the plunger rod and comprises a helical track portion and a longitudinal track portion; and wherein upon relative displacement of the plunger rod and said finger grip element, the at least one protrusion is guided along the guiding track.

Abstract: Medical devices and methods of use thereof are described. The device may include a body having a housing that defines a lumen, a piston within the housing, and an actuator operably coupled to the piston, wherein the piston is movable along the lumen by operating the actuator. The device also may include a cartridge insertable into the body and/or a flexible fitting configured for direct application to an eye of a subject.

Abstract: An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.

Abstract: Electronics assemblies with wireless capabilities for use in a drug delivery device. At least one of the electronics assemblies includes a processor, a sensor arranged to measure a fill level of a drug container and output a measurement to the processor, a wireless module to which an external device can be paired, a power module arranged to supply power to the assembly, and memory storing instructions for the processor to perform. The instructions include activating the sensor at a first time interval and receiving the measurement signal, for each activating of the sensor at the first time internal, determining, based on the received measurement signal, a change in the fill level of the drug container, and when the change in the fill level is detected, activating the wireless module for a first duration to enable the external device to pair with the wireless module.

Abstract: A method of treating a glass cylinder for a piston-cylinder arrangement for reducing the friction of a piston on an inner cylinder wall of the glass cylinder includes: elevating surface energy of glass of an interior bounded by the inner cylinder wall and hence lowering a contact angle of the glass with water. The contact angle is lowered by: a gas discharge that acts on the glass at the inner cylinder wall and is generated by an electric or electromagnetic field; or the action of ozone on the glass surface. The glass with the lowered contact angle is contacted with water to form a water film on the contacted glass.

Abstract: The present disclosure relates to a medical delivery device that includes a barrel having an inner surface, a plunger rod having a distal end inserted within the barrel, and a stopper attached to the distal end of the plunger rod and contacting at least a portion of the inner surface of the barrel. In at least one embodiment, the inner surface is hydrophilic. The stopper may include an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated with the one or more fluoropolymer layers. In some embodiments, the contact width between at least one rib having a sealing surface and the portion of the inner surface of the barrel measured at a compressibility of greater than about 7.9% of the stopper is less than about 1.0 mm.

Abstract: A plunger stopper (12) configured for attachment with a plunger rod (14) for use with a within a syringe barrel for high dose accuracy drug delivery. The stopper having a first portion (40) formed from a first material and a second portion (42) formed from a second material, wherein the second material has a greater rigidity than the first material and wherein the second portion is configured to be attached to a plunger rod. The second material can be in the form of an insert (44) which functions to reduce the amount of distortion of the stopper during use, reduce air bubble size variation from fill to fill, maintain a seal with the inner wall of the syringe barrel with lower contact pressure in a resting state and reduce the amount of hysteresis of the stopper. The stopper can be adapted for use with infusers, pens, and other types of auto-injectors.

Abstract: An injection system has: a gasket having a plurality of engaging claws, wherein each of the engaging claws includes an inner surface S1 which defines a hole H having an inlet with an enlarged diameter and an outer surface S2 inclined in a direction away from a perpendicular line P passing through a center of the hole H, and the engaging claws are to be displaced between a widened position and a narrowed position; a rain to be inserted into the hole H so as to engage with the engaging claws; a cylinder, into which the gasket is to be inserted, contacting the outer surfaces S2; and an injection device configured to move the ram forward and injecting a chemical solution in the cylinder. An annular groove which serves as a starting point of deformation of the engaging claws is formed on the gasket.

Abstract: The present invention relates to a rhinovaccination system for preventing and treating hepatitis B, comprising a hepatitis B vaccine composition for administration to nasal mucosa in combination with a medical nozzle device.

Abstract: The present disclosure relates to an injection device including: a housing; a carrier disposed within the housing for holding a syringe that has a needle at one end; a needle sleeve located within the housing and being axially moveable with respect to the housing between an extended position and a retracted position; a biasing element configured to bias the needle sleeve towards the extended position; and a locking mechanism configured to lock the needle sleeve in the extended position after use of the injection device, the locking mechanism comprising; a first locking member provided on and projecting from the carrier; and a second locking member comprising a deflectable arm provided on the needle sleeve and moveable between a relaxed position and a deflected position.

Abstract: The present invention relates to methods and products for demonstrating that intravenous access devices are substantially or completely void of residual drug products. The methods and products involve the use of colored liquids to allow the visual assessment of whether or not an intravenous device has been flushed.

Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.

Abstract: A Luer-lock fastening needle hub is proposed. The Luer-lock fastening needle hub has an insertion groove for a front end of a tapered tube of a barrel to receive the tapered tube into which a plunger is inserted, so that a plunger contact surface is inserted into the tapered tube of a front discharge end of the barrel. The Luer-lock fastening needle hub has a needle cap fastening grooves formed along an outer circumference thereof and “V”-shaped insertion guides are formed in four direction at front portions of openings of the needle cap fastening grooves, so that fastening protrusions formed on an inner surface of a needle cap are unaffectedly guided by the “V”-shaped insertion guides and are easily aligned and fastened to the needle cap fastening grooves.

Abstract: Surgical instruments and their methods of use are disclosed. In some embodiments, the surgical instrument may include a handle and an elongated shaft extending distally from the handle. The surgical instrument may also include a fastener deployment system for deploying fasteners from the elongated shaft including a reciprocating driveshaft disposed within the elongated shaft. In other embodiments, the fastener deployment system may include a follower disposed within the elongated shaft for displacing one or more fasteners within the elongated shaft towards a distal fastener deployment position. In some embodiments, the surgical instrument may include a magnetic preload lock-out to place the follower in a zero-load state in which the follower does not apply a preload to the fasteners.

Abstract: The invention relates to a medical injection device having a polymeric housing or housing parts. The housing comprises a moulded outer housing element and a moulded elongated tubular inner housing element. The elongated tubular inner housing element is formed as one unitary element and carries a pointer and one or more projections in predetermined and correlated positions. The pointer points to indicia on a scale drum and the projections engage the scale drum. The outer housing element is moulded over the elongated tubular inner housing element in a 2K moulding to form one single housing component.

Abstract: In the present disclosure, embodiments of dual-stage syringes are disclosed along with delivery systems incorporating the dual-stage syringes. Embodiments of the dual-stage syringes described herein include sleeved dual-stage syringes, turn-key dual-stage syringes and dual-stage syringes including one or more one-way valves.

Abstract: The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used disposables, thereby allowing accurate and safe use and convenient maintenance.

Abstract: A tampon applicator system includes a body and a protective ring extending outward from the body. The body includes a pinch zone and an opening. The pinch zone is disposed on the body below the protective ring and on an opposite side of the body from the opening. The protective ring is configured to protect the pinch zone from exposure on the opposite side of the protective ring.

Abstract: A resin syringe includes: a syringe body made of polyolefin, and a printing layer having a shape that extends in a band around an outer surface of the syringe body. The printing layer comprises components including chlorinated polypropylene having a degree of chlorination in a range of 15 to 30%, a colorant, and a filler. A plurality of recessed portions is formed in the outer surface of the syringe body on which the printing layer is printed and the recessed portions form a shape that extends in a band around the outer surface of the syringe body and that is entirely covered by the printing layer. Each of the recessed portions has a depth of 50 nm or more and less than 1 ?m and a width of 50 nm or more and less than 1 ?m and is filled with at least one of the components of the printing layer.

Abstract: A plunger, a syringe, system, and a method for increasing a seal between a sidewall of a plunger and a sidewall of a syringe are disclosed. The plunger includes a support ring and a cover disposed over and coupled to the support ring. A cavity defining a predetermined volume is defined between the support ring and the cover. The syringe includes a barrel defining an inner wall and the plunger inserted therein.

Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.

Abstract: A port placement guide may include a base, a member, and at least one tracking element. The base can be configured to couple to a surface of a patient at a preliminary port location for a robotic arm. The member can be coupled to the base and can comprise a first end and a second end opposite the first end. The at least one tracking element can be coupled to the member and can be configured to allow tracking of the member relative to the preliminary port location.

Abstract: Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and assembling them into syringes, e.g., pre-filled syringes.

Abstract: A medical dispensing device which includes a catheter, an applicator tip at a distal end of the catheter, the catheter and the applicator tip defining a lumen having a longitudinal axis and a distal opening, a plunger in the lumen and movable along the longitudinal axis, and a plurality of elements in the lumen proximal to the distal opening and distal to the plunger, the plurality of elements stacked along the longitudinal axis for dispersement of one element at a time through the distal opening via a force applied by the plunger.

Abstract: Syringe assemblies are provided including a partially pre-filled syringe barrel and a plunger rod that incorporates one or more retention elements on the plunger rod that prevents solution from entering a non-sterile area of the syringe when the plunger rod is pulled back. Methods to manufacture a sterilized partially-filled pre-fill syringe assembly are also disclosed.

Abstract: The present invention relates to a medicament delivery device comprising a housing, a compartment inside said housing for positioning a medicament container, an injection needle arranged to said housing, being connectable to said medicament container for delivering a dose of medicament, a manually operated activation mechanism for activating said device, an actuation mechanism operably connected to said activation mechanism and arranged to, upon activation of said activation mechanism, extend said injection needle from a first position inside said housing to a second position wherein a penetration of a patient is performed, a plunger rod arranged in said housing capable of acting on said medicament container for delivering a dose of medicament through said injection needle, a driver capable of acting on said plunger rod for delivering a dose of medicament.

Abstract: The present invention relates to a medicament delivery device for delivering a number of predetermined amounts of medicament, comprising a body having a proximal and an opposite distal end and extending along a longitudinal axis (L); a medicament container (20) arranged inside said body; a driving mechanism arranged inside said body and configured to act on said medicament container; a manually movable activation member (102) arranged on the distal end the body; a biased actuator member (64) arranged to be movable along the longitudinal axis and through the manually movable activation member (102), said biased actuator member being configured to protrude a predetermined distance from the distal end of the manually movable activation member and configured to interact with said driving mechanism when the biased actuator member is displaced said predetermined distance towards the proximal end of the body for delivering a predetermined amount of medicament; and an actuator guide member (90) arranged in the body a

Abstract: A method of making a two-component piston, the two-component piston including a piston cover as the first component and a piston body as the second component. The piston cover is arranged adjacent to the piston body and is configured to be moved relative to the piston body.

Abstract: An aspiration device can be used to aspirate an obstruction from a blood vessel. The aspiration device is configured to allow controlled one-handed aspiration yet maintain a syringe plunger feel of vacuum. The aspiration device also allows one-handed injection to empty the device when needed. Furthermore, mechanisms enable one-handed locking of a plunger position of the device to maintain vacuum when the user releases the device.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end, operate the syringe to supply the dose of medicament, and retract the syringe with the needle after delivering the medicament. An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: Microarray applicator (10000), a method of using the same and a kit. The microarray applicator comprising a housing (2000), a microarray holder (8100) and a plunger (7000). The plunger comprising a first ridge (7310) and a second ridge (7320), both engagable to a notch (2320). Microarray applicator does not uses springs or pre-biased mechanisms to reduce costs.

Abstract: Medical devices for delivering compositions or medical articles to a patient are disclosed. The medical plug delivery devices can include a fluid delivery device (e.g., a syringe), a frame, and a rotatable magazine. The rotatable magazine can include a plurality of chambers that each hold a composition or a medical article (e.g., a medical plug). By rotating the rotatable magazine relative to the frame, material within the chambers of the rotatable magazine can be sequentially deployed to a patient.

Abstract: Modules for housing electronic and electromechanical medical equipment including a system to measure and record administration of one or more IV medications or fluids for IV administration.

Abstract: A syringe receptacle device for collecting a liquid from an extraction device, a cylindrical barrel, and a plunger. The barrel has an inner circumferential surface that extends between opposite first and second ends. The first end of the barrel is adapted to be removably coupled to the extraction device. The plunger is slidably coupled to the barrel and includes a plunger head and an actuating rod. The plunger head is frictionally engaged with the inner circumferential surface of the barrel. The actuating rod is fixedly attached to the plunger head and extends out through the second end of the barrel.

Abstract: An injection device, comprising an interface for mounting on a syringe body, the interface comprising an internal passage delimited by an inner wall, a needle and a sheath for receiving said needle, said sheath comprising an outer wall provided with a contact portion of said sheath in contact with an attachment portion of the inner wall of the interface, wherein the contact portion comprises a first bead and in that the attachment portion comprises a second bead, the first and second beads each forming a ring protruding respectively on the contact portion and the attachment portion, the first bead being in contact with the second bead.

Abstract: An assembly for a container to be filled with a pharmaceutical drug is provided. The assembly includes a first component and a second component. The first component has at least one electronic device fully embedded therein, a first end provided with a first engagement feature and an opposing second end. The second component has a second engagement feature configured to engage the first engagement feature of the first component.

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. The distal end of the rolling diaphragm has a nozzle and a sidewall extending between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract: Devices and methods are disclosed that provide a syringe actuator device for use in the distention and irrigation of a body conduit before the use in a medical procedure such as a coronary bypass graft procedure. The device can be retrofit to a syringe by attaching it to the cap of the plunger and engaged to automatically apply pressure to fluid in the syringe. In some embodiments, elastic bands attached to the device are easily engaged or removed from a syringe during a procedure to limit the pressure on the syringe to various levels. The device may be overridden by an operator pushing on the plunger of the syringe as in normal syringe operation.

Abstract: A disposable syringe for use with a pneumatic driver. The syringe has an elongated barrel with a cap secured to the proximal end that has a through bore. A filter is secured to the cap interior of the barrel that covers an opening in the through bore interior of the barrel. The pneumatic driver includes a source of pressurized air; a support for receiving and locating the syringe; and a supply block configured to receive pressurized air from the source and having an outlet for delivery of pressurized air. The supply block is movable between a first position spaced apart from the cap of the syringe and a second position in contact with the cap with fluid communication being established between the outlet of the supply block and the through-bore in the cap.

Abstract: A digital syringe is used with conventional polymer disposable syringe construction to be practical in the medical environment. Errors associated with the larger volumes of the syringes (which exacerbate minor errors in plunger position) and the flexibility and dimensional variations of the polymer plungers are accommodated by direct measurement of the syringe plunger position rather than indirect measurement of motor position and inference of syringe plunger position. This direct measurement eliminates mechanical tolerances (“stack up”) in the motor, gear train, and lead screw on plunger movement, an effect exacerbated by flexibility of the plunger and changes in syringe resistance and medicament viscosity, for example, with different medicaments or when the syringe is refrigerated. The digital syringe may be combined with the motor unit to provide additional versatility.

Abstract: An injector comprises a cylindrical barrel, a movable body housed in the barrel, and a plunger coming into separable contact with the movable body. The movable body includes a main body having an outer diameter smaller than an inner diameter of the barrel, a disk-shaped seal body disposed on the main body and including an outer circumferential end brought into close contact with an inner circumferential surface of the barrel, and at least one projecting portion projecting from the main body toward the inner circumferential surface of the barrel. A distance from a central axis of the movable body to a leading end of the at least one projecting portion is smaller than a half of an outer diameter of the seal body.

Abstract: A supplementary device configured to be releasably attached to a distal end of a drug delivery device. The supplementary device comprising primary electronics, a non-contact acceleration sensor and a low power processor. The non-contact acceleration sensor is directed towards a proximal end of the drug delivery device and the low power processor is configured to: receive the signals output from the non-contact acceleration sensor; determine based on the signals that an outer needle cap of the drug delivery device has been removed; and in response to determining that an outer needle cap of the drug delivery device has been removed, send a wake-up signal to the primary electronics of the supplementary device.

Abstract: The present invention relates to a stopper for an injector for delivery of a pharmaceutical composition and to an injector with the stopper. The stopper has a stopper body with an actuating surface opposite an outlet surface, an axial length between the actuating surface and the outlet surface, and a transverse diameter, which stopper body defines an access diameter, the stopper at an axial location from the actuating surface comprising a deformable sealing element surrounding the stopper body and having an outer diameter, which is larger than the transverse diameter, which deformable sealing element is made from a thermoplastic elastomer and has an axial extension in the range of 5% and 95% of the axial length of the stopper body, and the stopper comprising a cavity at the axial location of the deformable sealing element, the cavity having a lateral extension larger than the access diameter of the stopper body.

Abstract: Medical devices capable of filling liquid into a syringe barrel while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel having a tapered sidewall portion for permitting air to vent from the chamber and preventing liquid from exiting the chamber, a plunger rod, and stopper. Another exemplary medical device includes a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel, a plunger rod and stopper. Also described is a medical device including a syringe barrel, plunger rod and stopper having a porous plug. Described is a medical device including a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel and a porous membrane disposed over the air venting grooves, a plunger rod and stopper. Methods for filling a syringe barrel with a liquid are also provided.

Abstract: A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.