With Piston Or Plunger For Expelling Material From Body Or Injector Reservoir Patents (Class 604/218)
  • Patent number: 11400217
    Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 2, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Yannick Hourmand, Timothy Donald Barrow-Williams, Matthew Ekman
  • Patent number: 11389590
    Abstract: The present disclosure relates to a administration assembly for a medicament delivery device, comprising: an elongated tubular delivery member cover (7), a cartridge holder (11) configured to be received by the delivery member cover (7) and configured to accommodate a medicament cartridge (31), the cartridge holder (11) having a radially flexible and radially inwards extending cartridge blocking protrusion (11b) configured to prevent the medicament cartridge (31) from moving proximally until being subjected to a proximally directed force larger than a threshold value, a needle assembly (13) comprising a double-edged needle having a proximally extending needle portion (13a) and a distally extending needle portion (13b), wherein the needle assembly (13) is configured to be assembled with the cartridge holder (11) so that the distally extending needle portion (13b) extends into the cartridge holder (11), and an administration mechanism including a plunger rod (27) configured to be proximally biased, wherein the
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 19, 2022
    Assignee: SHL MEDICAL AG
    Inventor: Oscar Alexandersson
  • Patent number: 11376369
    Abstract: A syringe including a barrel, a plunger moveably arranged within said barrel, and a plunger rod for driving said plunger. A first engagement member is arranged at the plunger rod, such that a longitudinal movement of the plunger rod yields a rotational movement of said first engagement member. The first engagement member includes a grooved surface. A second engagement member is arranged at the barrel to engage with said grooved surface of the first engagement member, wherein the first engagement member is arranged to move relative to the second engagement member, such that feedback is given to a user as the plunger rod is moved relative to the barrel for driving said plunger. The first engagement member is arranged at said plunger rod with a predetermined play there between.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 5, 2022
    Assignee: Galderma Holdings SA
    Inventors: Anders Holmqvist, Max Blomqvist, Jonas Törnsten
  • Patent number: 11364337
    Abstract: An automatic injector for delivering a pharmaceutical substance from a reservoir of a cartridge, the cartridge interconnected to a needle at its distal end and mechanically coupled to a plunger driver at its proximal end, the injector comprising a connecting feature on the cartridge a contact surface for contacting an injection site a frame connected to the contact surface, the frame having an interference element with a distal stop, the interference element sized to slidably link to the connecting feature and allow the cartridge to slide up to the distal stop, a snap element allowing the interference element to receive the connection feature, but inhibiting disconnection of the cartridge; the frame further comprising a driver mount, for fixedly containing a plunger driver, the driver for driving a plunger to empty the reservoir of the cartridge through the needle to inject fluid from the reservoir into the injection subject.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: June 21, 2022
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu
  • Patent number: 11364343
    Abstract: An autoinjector including a plunger for engaging with the bung, a collar located around the plunger, an insertion spring biasing the collar relative to the rear of the device, and a delivery spring biasing the plunger relative to the collar. The device further includes a stop feature defining the limit of axial movement of the syringe body through the housing, and a collar release mechanism for releasing the collar from the rear of the device to commence insertion and a plunger release mechanism for releasing the plunger from the collar while substantially preventing rearward axial movement of the collar, following insertion, to commence delivery of the medicament. Following release of the plunger from the collar, the plunger is configured to move axially and rotationally relative to the collar, the direction of rotation being changed one or more times with axial movement of the plunger.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: June 21, 2022
    Assignee: Owen Mumford Limited
    Inventor: Andrew Hung
  • Patent number: 11337628
    Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe having a barrel and a plunger movable within the barrel. In response to depression of the plunger within the barrel, an instrument may be advanced distally. The instrument may include a catheter, a probe, a light tube for disinfection, or another suitable instrument. In response to depression of the plunger within the barrel, a distal end of the instrument may move through a catheter assembly coupled to the delivery device and into vasculature of a patient.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: May 24, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Jonathan Karl Burkholz, Derek Jewell, Joseph Spataro
  • Patent number: 11311685
    Abstract: Various implementations include a tissue lifting device that is operable using one hand. The device includes a housing, an actuator that is slidably moveable through a channel within the housing, and a lifting mechanism adjacent a distal end of the housing. The actuator causes the lifting mechanism to lift a tissue. In some implementations, the housing includes a needle adjacent the distal end of the housing that punctures the tissue and allows for injection of a composition behind the tissue. The lifting mechanism according to some implementations is a suction-based (or aspiration) system. And, in other implementations, the lifting mechanism is a grasping system.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: April 26, 2022
    Assignees: GEORGIA TECH RESEARCH CORPORATION, DUKE UNIVERSITY
    Inventors: R. Rand Allingham, C. Ross Ethier, Jordan David Rehwaldt
  • Patent number: 11305060
    Abstract: An actuator for synchronized injection and aspiration, comprising: a first rod, having a length equal to an inner length between a head of a first plunger of a first standard-size syringe and a seal of the first plunger, and having a width smaller than a gap created between the first plunger and a barrel of the first standard-size syringe; a second rod, having a length equal to an inner length between a head of a second plunger of a second standard-size syringe and a seal of the second plunger, and having a width smaller than a gap created between the second plunger and a barrel of the second standard-size syringe; a flexible connector mechanically attached to a distal end of the first rod at a first end and to a distal end of the second rod at a second end.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: April 19, 2022
    Assignee: V.V.T. Med Ltd.
    Inventor: Zeev Brandeis
  • Patent number: 11285273
    Abstract: A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: March 29, 2022
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Michael Spohn, Michael McDermott
  • Patent number: 11278370
    Abstract: A method of operating a marking device includes defining an initial condition wherein a cannula is in an extended position and a stylet is in a ready position in the extended cannula, and, starting from the initial condition with the cannula in the extended position, sequentially: effecting movement of the stylet from a ready position to an implant position, ejecting an imaging marker through a distal opening in a cannula distal end of the cannula, and then; effecting a simultaneous unitary retraction of the cannula and stylet after ejection of the imaging marker from the distal opening in the cannula distal end.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: March 22, 2022
    Assignee: BARD PERIPHERAL VASCULAR, INC.
    Inventors: Steven E. Field, Ryan L. Goosen, Richard E. Davis, Richard M. Chesbrough
  • Patent number: 11266793
    Abstract: A syringe with high safety in use having a syringe body adapted to accommodate slidingly a plunger. The syringe body has a protruding end that is adapted to allow the mating of a base end of a needle. The syringe further includes elements for removing the needle and/or a cap interposed between the syringe body and the base end of the needle. The needle removal elements are adapted to be moved in a rotary direction for removal of the needle and/or the cap.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 8, 2022
    Assignee: Aghetto S.r.l.
    Inventor: Carlo Giuberchio
  • Patent number: 11202857
    Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 21, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
  • Patent number: 11169058
    Abstract: Described is an automated reagent mixing container for separately storing and automatically mixing together at least two stored reagent components.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: November 9, 2021
    Assignee: INSTRUMENTATION LABORATORY COMPANY
    Inventors: Gert Blankenstein, Hansong Zeng, Jr.
  • Patent number: 11135376
    Abstract: The disclosure provides a dose controlled multi-shot injection device comprising a housing and a dose setting mechanism, wherein the dose setting mechanism includes a drive spring, a rotatable dose setting handle adapted to set a dose of medicament, thereby biasing the drive spring, and a ratchet mechanism for maintaining the drive spring in a biased state against a spring force at a set dose.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 5, 2021
    Assignee: Sanofi
    Inventor: Markus Ploch
  • Patent number: 11109785
    Abstract: A needle including a cannula having a multi-beveled point is disclosed. The multi-beveled point includes a primary bevel, two middle bevels, and two tip bevels. Each of the middle bevels extends between the primary bevel and one of the tip bevels. The primary bevel is provided on the cannula at a first angle of inclination and a first angle of rotation, the two middle bevels are provided on the cannula at a second angle of inclination and a second angle of rotation, and the two tip bevels are provided on the cannula at a third angle of inclination and a third angle of rotation. The third angle of inclination is greater than the second angle of inclination, the second angle of inclination is greater than the first angle of inclination, and the second angle of rotation is equal to the third angle of rotation.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: September 7, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Matthew Siang Si Woo, Ravi Attri, Arun U. Nair, Bo Yon Lillian Yoo
  • Patent number: 11097059
    Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: August 24, 2021
    Assignee: Owen Mumford Limited
    Inventors: Callum Davies, Abiodun Falodi, Matthew Farmer, Oliver Gould, Oliver Hyde, Parshia Moghadas, Timothy Muller, Tahir Shabudin
  • Patent number: 11083846
    Abstract: Disclosed are syringes that allow one-handed operation for measuring and dispensing a medicament, provide consistent finger placement on the syringe barrel. The syringes have a generally oval exterior shape that comfortably fits a user's hand and prevents rolling of the syringe when placed on a surface. Due to the shape of the syringes, the dispensing tip will not touch a surface or substrate when the syringe is placed thereon, providing improved hygiene and reduced contamination. The syringes preferably have a dosage marking on the barrel that provides ease of seeing the withdrawn medicament. The dosage marking can be raised and/or colored and/or made light sensitive. The raised markings can provide an audible and/or tactile indication of the dose of medicament drawn into or out of the syringe.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 10, 2021
    Assignee: GlaxoSmithKline Consumer Healthcare (UK) IP Limited
    Inventors: George Cave, Paul Richard Draper, Daniel Paul Salisbury
  • Patent number: 11058829
    Abstract: An injection device is used for “tattooing” markers inside the heart of a patient at specific locations. Placement within the heart of markers, such as points marked with a radiopaque dye, may reduce the use of x-ray dye and echocardiography, may allow a quicker cardiac procedure, and thus may improve the procedure outcome for the patient. Alternatively or additionally to cardiac marking with a radiopaque dye, cardiac tissue fibrosis, cardiac tissue contraction, and/or cardiac tissue stiffening (or hardening) can be promoted at specific locations by delivering a suitable substance.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 13, 2021
    Inventors: Michael B. McDonald, Shalaka V. Bapat
  • Patent number: 11052197
    Abstract: A prefilled injection pen for injecting insulin, the prefilled injection pen including: a screw rod, a memory connection barrel, a fixed barrel and a rotating barrel. A plurality of first one-way teeth is evenly distributed on an end surface of the rotating barrel. The memory connection barrel is disposed inside the rotating barrel. The inner wall of the memory connection barrel is provided with a protrusion matching a thread of the screw rod. An end face of one end of the fixed barrel is provided with a ratchet pawl matching the first one-way teeth. The fixed barrel is also provided with a first inner thread matching the screw rod. The screw rod is provided with two machined plane surfaces. A plunger is disposed at one end of the screw rod and a stopper is disposed in a thread groove at the other end of the screw rod.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: July 6, 2021
    Assignee: BEIJING GANGAN TECHNOLOGY CO., LTD.
    Inventor: Chunsheng Wang
  • Patent number: 11033684
    Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 15, 2021
    Assignee: AMGEN INC.
    Inventors: Hans Stenberg Knudsen, Christian Plambech, Rasmus Øhlenschlæger, Jørgen Jørgensen
  • Patent number: 11020527
    Abstract: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 1, 2021
    Assignee: ALK-ABELLÓ A/S
    Inventor: Jens Mikkelsen
  • Patent number: 10987505
    Abstract: A fluid connector assembly is disclosed. The fluid connector assembly includes a body portion, a plug portion located on the body portion, the plug portion comprising a fluid path, a tubing, a first end of the tubing fluidly connected to the plug fluid path, a catch feature located on a first end of the body portion and configured to interact with a reservoir, and a latching feature located on a second end of the body portion, the latching feature configured to interact and lock onto the reservoir.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 27, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Gregory R. Lanier, Jr., Kevin L. Grant, Dean Kamen, Lisa A. Panneton, Bright C. K. Foo, Stephen L. Fichera, Thomas F. Soldau, David D. B. Cannan
  • Patent number: 10983034
    Abstract: A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: April 20, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Nathan Crum, Michael Otter
  • Patent number: 10953218
    Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure an adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. The syringe assemblies include a plunger rod, a syringe barrel, and the reservoir collar that permits disinfection of a hub of a VAD connector upon connection to the reservoir collar. Also described are methods of disinfecting the vascular access devices.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: March 23, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Nichola Charles, Adam Zerda
  • Patent number: 10945860
    Abstract: A medical compound preparation and delivery system, including a delivery device, the device including a depressible trigger operably coupled to move a plunger; a cartridge releasably coupled to the delivery device, the cartridge defining a lumen therethrough to receive at least a portion of the plunger therein; a receptacle defining a cavity therein for receiving a medical compound; a first tube slidably positionable within the cavity of the receptacle; and a second tube slidably positionable within the first tube, wherein the cartridge is slidably positionable within the second tube.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: March 16, 2021
    Inventor: James Scott Hay
  • Patent number: 10849688
    Abstract: An injection aid system and a social aid system having a computing system with at least one processor and a memory device. The computing system can be configured to generate a at least one of a virtual environment and an augmented environment. A display device can be coupled to the computing system and configured to visually display the environment. The injection aid system can further include an injection tool and a treatment target configured to receive a simulated injection by the injection tool. The injection tool can have a needle and a plunger.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: December 1, 2020
    Assignee: Truinject Corp.
    Inventors: Gabrielle A. Rios, Daniel David Rios, Clark B. Foster
  • Patent number: 10765464
    Abstract: One aspect relates to a device to produce a bone cement paste from a monomer liquid and a cement powder as starting components of the bone cement paste, and to dispense the mixed bone cement paste.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: September 8, 2020
    Assignee: Heraeus Medical GmbH
    Inventors: Thomas Kluge, Rainer Strathausen, Sebastian Vogt
  • Patent number: 10751474
    Abstract: The present invention relates to a piston for a cartridge to be filled with a medicament, the piston comprising: a first piston member (12) comprising a first material and forming a distal end face (22) of the piston, a second piston member (14) comprising a second material of lower compressibility compared to the first material, wherein the second piston member (14) is arranged in a cupped receptacle (16) of the first piston member (12) and provides a thrust receiving surface (25) at a proximal end (24) of the piston.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 25, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Ramatullah Qurishi, Martin Otten, Stefan Trinkle, Jorn Mockel, Sebastian Thiel
  • Patent number: 10722655
    Abstract: An injection device, method, and system for drug delivery includes a primary container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug, an injection drive mechanism comprising a plunger for acting on the stopper and an energy source for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug, the force causing the plunger to accelerate to a velocity prior to acting on the stopper, and a damping mechanism for reducing the velocity of the plunger prior to acting on the stopper. The damping mechanism can include a dashpot or an energy absorbing material associated with the plunger. Alternatively or additionally, the damping mechanisms can include absorbing material disposed between support members of an outer casing of the injection device and the primary container.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: July 28, 2020
    Assignee: AMGEN INC.
    Inventors: Christopher Folk, Scott R. Gibson
  • Patent number: 10688245
    Abstract: A plunger for a syringe that includes a barrel includes: a gasket mounting portion located at a distal end of the plunger; a disk positioned at a proximal end of the gasket mounting portion; a shaft extending proximally from the disk, wherein the shaft comprises a plurality of slats extending proximally from the disk; a pressing portion located at a lower end of the shaft; and a plunger inclination-prevention unit that is located at a distal end of the shaft and is configured to inhibit the plunger from inclining inside the barrel of the syringe. The plunger inclination-prevention unit comprises one or more axially inclined plates, each having a first end disposed on the disk, extending obliquely proximal with respect to a central axis of the shaft, and having a second end disposed on one of the slats.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 23, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Koichiro Furukawa
  • Patent number: 10675415
    Abstract: A pharmaceutical syringe unit is configured to be mounted to a pharmaceutical injection device main body and hold a pharmaceutical-filled pharmaceutical syringe, in order to mount the pharmaceutical syringe to a pharmaceutical injection device, wherein a syringe cover is configured to slide forward and backward with respect to a distal end cap by operation of the pharmaceutical injection device main body, thereby allowing movement between a needle insertion position at which insertion of an injection needle into a target is to be completed, and a needle withdrawal position at which withdrawal of the injection needle from the target is to be completed, and a guide component is configured to guide the syringe cover over a range that is greater than a distance between the needle insertion position and the needle withdrawal position.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 9, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Yukihiro Takabatake, Toshiaki Iio, Seiji Kikuchi, Yutaro Fujino
  • Patent number: 10668221
    Abstract: A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: June 2, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Joseph E. Bisegna, Jared E. Neff
  • Patent number: 10653401
    Abstract: A medical device for repairing soft tissue is disclosed. The medical device includes a cannulated probe positionable a tear in the soft tissue and a stop. The cannulated probe has an inlet about a proximal end and at least one outlet about a distal end with a lumen therethrough. The inlet is operatively connectable to an adhesive source to receive the adhesive therein. The outlet(s) is/are positionable about the tear to emit the adhesive about the tear. The stop is disposable about a periphery of the probe a distance from the inlet, and is positionable adjacent a surface of the soft tissue to terminate advancement of the cannulated probe into the soft tissue whereby a delivery portion of the cannulated probe is positionable about the soft tissue to deliver the adhesive about the tear.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: Steve Bowman, Ruth Cheng, Graham Smith, Paul Alexander Torrie
  • Patent number: 10646703
    Abstract: This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: May 12, 2020
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10589027
    Abstract: An autoinjector having a body (1, 2), a reservoir (S) including a piston, a piston rod (5) movable between a rest position and an injection position, an actuator spring (6) urging the piston rod (5) towards the injection position, and a force-adjustment system (7, 8) to exert a force (F2) on the piston rod (5), adding to the force exerted by the spring (6) at the beginning of injection. The system has two pivot members (7) co-operating with the piston rod (5), the pivot members (7) connected together by two resilient elements (8). The body (1, 2) includes a sleeve (3), the pivot members (7) pivotally mounted on the sleeve (3) to pivot about stationary pins (79). The autoinjector includes an end-of-injection indicator that includes an indication portion movable and/or deformable relative to the body (1, 2) to co-operate with a viewing window after the end of injection.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 17, 2020
    Assignee: APTAR FRANCE SAS
    Inventor: David Fabien
  • Patent number: 10569023
    Abstract: In a conventional laminated gasket production method, when a product of a laminated gasket is demolded from a mold, the product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the laminated gasket. These minute scratches are liable to prevent reliable sealing of a liquid drug. The present invention is a method for producing a gasket to be used for a medical syringe and is characterized by including the steps of: preparing a gasket molding mold; molding a gasket having a circumferential surface portion in the mold with the gasket being laminated with a lamination film; and demolding the gasket from the mold, and then forming a groove only in the lamination film circumferentially of the circumferential surface portion of the gasket.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: February 25, 2020
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Hiroaki Nakano, Seiji Hara, Hiroyuki Kaneko
  • Patent number: 10550027
    Abstract: [Object] To provide a means manufacturing a medical glass container with less generation of a crack. [Solution] A method for manufacturing a medical glass container includes a first process of moving the tip of an ignited point burner 30 from a standby position where a flame 31 does not contact a vial 10 to a position where the tip of the ignited point burner 30 faces an opening 16 in the outside of the vial 10, a second process of inserting the tip of the point burner 30 into an internal space 14 of the vial 10, a third process of applying the flame 31 to an inner surface 15 of the vial 10 while holding the tip of the point burner 30 in the internal space 14, a fourth process of moving the tip of the point burner 30 to the outside from the internal space 14, and a fifth process of moving the tip of the point burner 30 from the position where the tip of the point burner 30 faces the opening 16 to the standby position.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: February 4, 2020
    Assignee: NIPRO CORPORATION
    Inventors: Yoshio Inoue, Kazuhisa Moriuchi, Yoshihiro Kawai, Atsushi Ishikawa
  • Patent number: 10549048
    Abstract: A syringe assembly includes a barrel, and a seal cap mounted to the barrel. The seal cap includes a closed distal end portion, an open proximal end portion, a hollow portion including a barrel end storage portion configured to store a barrel end portion, and a puncture needle storage portion extending from the barrel end storage portion, an insertion allowing portion configured to receive a puncture needle tip of a puncture needle guided to the distal end of the puncture needle storage portion, and a projection portion formed on an inner surface of the barrel end storage portion. The projection portion has a top portion, a distal inclined portion, and a proximal inclined portion extending from the top portion toward the open proximal end portion. A non-stick surface for inhibiting sticking to a barrel end portion of the barrel is formed on an inner surface of the projection portion.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: February 4, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Masafumi Takemoto, Tsuyoshi Yoshimoto
  • Patent number: 10543318
    Abstract: A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: January 28, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Milan Ivosevic, Girum Yemane Tekeste, Andrew Wong, Michael Vincent Quinn, Andrzej Baranski
  • Patent number: 10512721
    Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engagable with the piston regardless of a rotational orientation of the piston relative to the plunger.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: December 24, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael J. Swantner, Richard A. Seman, Barry L. Tucker, Arthur E. Uber, III, Kevin P. Cowan, James A. Dedig, Christopher D. Capone, Jaroslaw Wlodarczyk
  • Patent number: 10493484
    Abstract: Implementations of an applicator syringe are provided. In some implementations, the applicator syringe may be configured to dispense a lubricant from a dispensing needle thereof. In some implementations, the applicator syringe may be configured so that the plunger shaft and the dispensing needle are removable when not in use. In some implementations, when the applicator syringe has been disassembled, the dispensing needle may be stored within the barrel of the applicator syringe and the plunger shaft secured about the exterior of the barrel. In some implementations, the applicator syringe may comprise a barrel having a finger flange, a plunger positioned within the interior chamber of the barrel, a plunger shaft configured to urge the plunger forward, a dispensing needle that can be removably secured to the front end of the barrel, a removable cap, and a barrel plug.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 3, 2019
    Inventors: Brian Keeney, David S. Giessel
  • Patent number: 10493207
    Abstract: The present disclosure relates to medical delivery devices that include a barrel having an inner surface, and in at least one embodiment, the inner surface is hydrophilic. The medical delivery device may further include a stopper may having an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated to the one or more fluoropolymer layers. In some embodiments, the contact angle of the inner surface of the barrel is less than about 58°. Additionally, the stopper includes a sliding surface that is less than about 2.0 mm. The barrel provides inner surface that in combination with the fluoropolymer laminate or fluoropolymer film achieve high levels of air and liquid impermeability while also maintaining an acceptably low break loose force, low average glide force, and low glide force variation. In some embodiments, the compressibility stopper against the barrel is greater than about 7.9%.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 3, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael C. Berg, Daniel H. Todd, Eric J. Van Voorhees
  • Patent number: 10420896
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, includes an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in axial distal direction, a drive sleeve rotatably supported in the housing at least in a dose incrementing direction against the action of a spring element, and a ratchet mechanism to rotatably fix the drive sleeve relative to the housing. A first ratchet body has a first and a second ratchet element to alternately engage with a toothed profile of a second ratchet body. One of the first and second ratchet bodies is operably engaged with the housing and wherein the other one of the first and second ratchet bodies is operably engaged with the drive sleeve.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: September 24, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Wolfgang Pelzer, Björn Wilden, Philipp Zeitz
  • Patent number: 10406288
    Abstract: The invention provides a delivery mechanism for an autoinjector comprising: a first drive member configured to drive a first component in an axial direction; a second drive member configured to drive a second component in an axial direction; and a release mechanism configured to control a sequence of release of the first drive member and the second drive member, wherein the release mechanism is positioned at least partially within the first or second drive member.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: September 10, 2019
    Assignee: OVAL MEDICAL TECHNOLOGIES LIMITED
    Inventors: Dominic Charles Reber, Congyi Huang, Matthew Young
  • Patent number: 10363375
    Abstract: A pre-filled injection device includes a tubular containment body extending between a first and second openings, inside which are hermetically separated first and second containment chambers. A first substance is contained in the first containment chamber. First and second plugs inside the tubular body define the second containment chamber, and slide inside the tubular body. A second liquid substance inside the second containment chamber is intended to be mixed inside the tubular body with the first substance for reconstituting an injectable solution. A dosing reservoir has an inlet and an outlet, the inlet being in communication with the first containment chamber so that the first containment chamber extends between the first plug and the dosing reservoir inlet. The dosing reservoir contains a fraction of the injectable solution. The first plug includes a projecting appendix passing through and entering the dosing reservoir to eject the fraction of solution.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 30, 2019
    Assignee: OROFINO PHARMACEUTICALS GROUP S.r.l.
    Inventor: Ernesto Orofino
  • Patent number: 10357611
    Abstract: A closure piece for a powder syringe is proposed, having a main body, a sealing element, which is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe, when the closure piece is disposed in the closing position thereof on the powder syringe, and a channel, which passes through the main body and the sealing element and has a proximal and a distal end. The closure piece is characterized by a retaining element, which is configured and/or can be disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially, preferably completely, prevented from penetrating the channel, when the closure piece is disposed in the closing position thereof on the powder syringe.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: July 23, 2019
    Assignee: VETTER PHARMA-FERTIGUNG GMBH & CO. KG
    Inventors: Joachim Glocker, Tilman Roedle
  • Patent number: 10335539
    Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: July 2, 2019
    Assignee: Osprey Medical, Inc.
    Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
  • Patent number: 10286151
    Abstract: A plunger seal for a drug delivery device may have a mobile and an enhanced sealing parked state. Optionally, the cartridge is stored with the plunger seal in the parked state. Optionally, drug discharge occurs with the plunger seal in the mobile state. For example in the parked state there may be increased normal force between the plunger seal and an inner wall of the cartridge. Optionally there is limited deformation of the plunger seal between the parked and mobile states. Optionally the plunger seal is biased to the parked state. Optionally, a distal force switches the plunger seal to the mobile state. For example, the plunger seal may have an inner cavity that is expanded radially by core. A biasing element optionally biases the core wedging it proximally to the parked state. A distal force on the core may push it distally to the mobile state.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 14, 2019
    Assignee: West Pharma. Services IL, Ltd.
    Inventor: Oz Cabiri
  • Patent number: 10279115
    Abstract: A syringe includes a gasket, a barrel, and a plunger. The plunger includes a helical rib provided at a head portion, and the gasket includes a threaded engagement portion configured to threadedly engaged with the helical rib, a plunger-retaining annular rib, and an accommodation portion for accommodating a part of the plunger at which the helical rib is formed. The annular rib includes a rib absent portion for guiding, to the accommodation portion, the helical rib reaching the annular rib. The gasket further includes an intermediate annular rib provided at a part on a proximal side of the retaining annular rib and a part defined on a side of the distal end of the helical projection, between a distal side annular rib and a proximal side annular rib.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: May 7, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Koichiro Furukawa
  • Patent number: 10232120
    Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket having at least two annular projections and at least one annular valley on its sliding surface, the sliding surface being at least partially provided with immobilized polymer chains, the annular projections including a first projection nearest to the top surface and any other projection, the outer diameters of the other projection and the annular valley being in the range of 94 to 98% and 85 to 92%, respectively, with respect to the outer diameter of the first projection taken as 100%.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 19, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa