With Piston Or Plunger For Expelling Material From Body Or Injector Reservoir Patents (Class 604/218)
  • Patent number: 11058829
    Abstract: An injection device is used for “tattooing” markers inside the heart of a patient at specific locations. Placement within the heart of markers, such as points marked with a radiopaque dye, may reduce the use of x-ray dye and echocardiography, may allow a quicker cardiac procedure, and thus may improve the procedure outcome for the patient. Alternatively or additionally to cardiac marking with a radiopaque dye, cardiac tissue fibrosis, cardiac tissue contraction, and/or cardiac tissue stiffening (or hardening) can be promoted at specific locations by delivering a suitable substance.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 13, 2021
    Inventors: Michael B. McDonald, Shalaka V. Bapat
  • Patent number: 11052197
    Abstract: A prefilled injection pen for injecting insulin, the prefilled injection pen including: a screw rod, a memory connection barrel, a fixed barrel and a rotating barrel. A plurality of first one-way teeth is evenly distributed on an end surface of the rotating barrel. The memory connection barrel is disposed inside the rotating barrel. The inner wall of the memory connection barrel is provided with a protrusion matching a thread of the screw rod. An end face of one end of the fixed barrel is provided with a ratchet pawl matching the first one-way teeth. The fixed barrel is also provided with a first inner thread matching the screw rod. The screw rod is provided with two machined plane surfaces. A plunger is disposed at one end of the screw rod and a stopper is disposed in a thread groove at the other end of the screw rod.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: July 6, 2021
    Assignee: BEIJING GANGAN TECHNOLOGY CO., LTD.
    Inventor: Chunsheng Wang
  • Patent number: 11033684
    Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 15, 2021
    Assignee: AMGEN INC.
    Inventors: Hans Stenberg Knudsen, Christian Plambech, Rasmus Øhlenschlæger, Jørgen Jørgensen
  • Patent number: 11020527
    Abstract: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 1, 2021
    Assignee: ALK-ABELLÓ A/S
    Inventor: Jens Mikkelsen
  • Patent number: 10987505
    Abstract: A fluid connector assembly is disclosed. The fluid connector assembly includes a body portion, a plug portion located on the body portion, the plug portion comprising a fluid path, a tubing, a first end of the tubing fluidly connected to the plug fluid path, a catch feature located on a first end of the body portion and configured to interact with a reservoir, and a latching feature located on a second end of the body portion, the latching feature configured to interact and lock onto the reservoir.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 27, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Gregory R. Lanier, Jr., Kevin L. Grant, Dean Kamen, Lisa A. Panneton, Bright C. K. Foo, Stephen L. Fichera, Thomas F. Soldau, David D. B. Cannan
  • Patent number: 10983034
    Abstract: A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: April 20, 2021
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Nathan Crum, Michael Otter
  • Patent number: 10953218
    Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure an adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. The syringe assemblies include a plunger rod, a syringe barrel, and the reservoir collar that permits disinfection of a hub of a VAD connector upon connection to the reservoir collar. Also described are methods of disinfecting the vascular access devices.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: March 23, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Nichola Charles, Adam Zerda
  • Patent number: 10945860
    Abstract: A medical compound preparation and delivery system, including a delivery device, the device including a depressible trigger operably coupled to move a plunger; a cartridge releasably coupled to the delivery device, the cartridge defining a lumen therethrough to receive at least a portion of the plunger therein; a receptacle defining a cavity therein for receiving a medical compound; a first tube slidably positionable within the cavity of the receptacle; and a second tube slidably positionable within the first tube, wherein the cartridge is slidably positionable within the second tube.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: March 16, 2021
    Inventor: James Scott Hay
  • Patent number: 10849688
    Abstract: An injection aid system and a social aid system having a computing system with at least one processor and a memory device. The computing system can be configured to generate a at least one of a virtual environment and an augmented environment. A display device can be coupled to the computing system and configured to visually display the environment. The injection aid system can further include an injection tool and a treatment target configured to receive a simulated injection by the injection tool. The injection tool can have a needle and a plunger.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: December 1, 2020
    Assignee: Truinject Corp.
    Inventors: Gabrielle A. Rios, Daniel David Rios, Clark B. Foster
  • Patent number: 10765464
    Abstract: One aspect relates to a device to produce a bone cement paste from a monomer liquid and a cement powder as starting components of the bone cement paste, and to dispense the mixed bone cement paste.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: September 8, 2020
    Assignee: Heraeus Medical GmbH
    Inventors: Thomas Kluge, Rainer Strathausen, Sebastian Vogt
  • Patent number: 10751474
    Abstract: The present invention relates to a piston for a cartridge to be filled with a medicament, the piston comprising: a first piston member (12) comprising a first material and forming a distal end face (22) of the piston, a second piston member (14) comprising a second material of lower compressibility compared to the first material, wherein the second piston member (14) is arranged in a cupped receptacle (16) of the first piston member (12) and provides a thrust receiving surface (25) at a proximal end (24) of the piston.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 25, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Ramatullah Qurishi, Martin Otten, Stefan Trinkle, Jorn Mockel, Sebastian Thiel
  • Patent number: 10722655
    Abstract: An injection device, method, and system for drug delivery includes a primary container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug, an injection drive mechanism comprising a plunger for acting on the stopper and an energy source for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug, the force causing the plunger to accelerate to a velocity prior to acting on the stopper, and a damping mechanism for reducing the velocity of the plunger prior to acting on the stopper. The damping mechanism can include a dashpot or an energy absorbing material associated with the plunger. Alternatively or additionally, the damping mechanisms can include absorbing material disposed between support members of an outer casing of the injection device and the primary container.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: July 28, 2020
    Assignee: AMGEN INC.
    Inventors: Christopher Folk, Scott R. Gibson
  • Patent number: 10688245
    Abstract: A plunger for a syringe that includes a barrel includes: a gasket mounting portion located at a distal end of the plunger; a disk positioned at a proximal end of the gasket mounting portion; a shaft extending proximally from the disk, wherein the shaft comprises a plurality of slats extending proximally from the disk; a pressing portion located at a lower end of the shaft; and a plunger inclination-prevention unit that is located at a distal end of the shaft and is configured to inhibit the plunger from inclining inside the barrel of the syringe. The plunger inclination-prevention unit comprises one or more axially inclined plates, each having a first end disposed on the disk, extending obliquely proximal with respect to a central axis of the shaft, and having a second end disposed on one of the slats.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 23, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Koichiro Furukawa
  • Patent number: 10675415
    Abstract: A pharmaceutical syringe unit is configured to be mounted to a pharmaceutical injection device main body and hold a pharmaceutical-filled pharmaceutical syringe, in order to mount the pharmaceutical syringe to a pharmaceutical injection device, wherein a syringe cover is configured to slide forward and backward with respect to a distal end cap by operation of the pharmaceutical injection device main body, thereby allowing movement between a needle insertion position at which insertion of an injection needle into a target is to be completed, and a needle withdrawal position at which withdrawal of the injection needle from the target is to be completed, and a guide component is configured to guide the syringe cover over a range that is greater than a distance between the needle insertion position and the needle withdrawal position.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: June 9, 2020
    Assignee: PHC HOLDINGS CORPORATION
    Inventors: Yukihiro Takabatake, Toshiaki Iio, Seiji Kikuchi, Yutaro Fujino
  • Patent number: 10668221
    Abstract: A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: June 2, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Joseph E. Bisegna, Jared E. Neff
  • Patent number: 10653401
    Abstract: A medical device for repairing soft tissue is disclosed. The medical device includes a cannulated probe positionable a tear in the soft tissue and a stop. The cannulated probe has an inlet about a proximal end and at least one outlet about a distal end with a lumen therethrough. The inlet is operatively connectable to an adhesive source to receive the adhesive therein. The outlet(s) is/are positionable about the tear to emit the adhesive about the tear. The stop is disposable about a periphery of the probe a distance from the inlet, and is positionable adjacent a surface of the soft tissue to terminate advancement of the cannulated probe into the soft tissue whereby a delivery portion of the cannulated probe is positionable about the soft tissue to deliver the adhesive about the tear.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 19, 2020
    Assignee: Smith & Nephew, Inc.
    Inventors: Steve Bowman, Ruth Cheng, Graham Smith, Paul Alexander Torrie
  • Patent number: 10646703
    Abstract: This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: May 12, 2020
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10589027
    Abstract: An autoinjector having a body (1, 2), a reservoir (S) including a piston, a piston rod (5) movable between a rest position and an injection position, an actuator spring (6) urging the piston rod (5) towards the injection position, and a force-adjustment system (7, 8) to exert a force (F2) on the piston rod (5), adding to the force exerted by the spring (6) at the beginning of injection. The system has two pivot members (7) co-operating with the piston rod (5), the pivot members (7) connected together by two resilient elements (8). The body (1, 2) includes a sleeve (3), the pivot members (7) pivotally mounted on the sleeve (3) to pivot about stationary pins (79). The autoinjector includes an end-of-injection indicator that includes an indication portion movable and/or deformable relative to the body (1, 2) to co-operate with a viewing window after the end of injection.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 17, 2020
    Assignee: APTAR FRANCE SAS
    Inventor: David Fabien
  • Patent number: 10569023
    Abstract: In a conventional laminated gasket production method, when a product of a laminated gasket is demolded from a mold, the product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the laminated gasket. These minute scratches are liable to prevent reliable sealing of a liquid drug. The present invention is a method for producing a gasket to be used for a medical syringe and is characterized by including the steps of: preparing a gasket molding mold; molding a gasket having a circumferential surface portion in the mold with the gasket being laminated with a lamination film; and demolding the gasket from the mold, and then forming a groove only in the lamination film circumferentially of the circumferential surface portion of the gasket.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: February 25, 2020
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Hiroaki Nakano, Seiji Hara, Hiroyuki Kaneko
  • Patent number: 10549048
    Abstract: A syringe assembly includes a barrel, and a seal cap mounted to the barrel. The seal cap includes a closed distal end portion, an open proximal end portion, a hollow portion including a barrel end storage portion configured to store a barrel end portion, and a puncture needle storage portion extending from the barrel end storage portion, an insertion allowing portion configured to receive a puncture needle tip of a puncture needle guided to the distal end of the puncture needle storage portion, and a projection portion formed on an inner surface of the barrel end storage portion. The projection portion has a top portion, a distal inclined portion, and a proximal inclined portion extending from the top portion toward the open proximal end portion. A non-stick surface for inhibiting sticking to a barrel end portion of the barrel is formed on an inner surface of the projection portion.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: February 4, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Masafumi Takemoto, Tsuyoshi Yoshimoto
  • Patent number: 10550027
    Abstract: [Object] To provide a means manufacturing a medical glass container with less generation of a crack. [Solution] A method for manufacturing a medical glass container includes a first process of moving the tip of an ignited point burner 30 from a standby position where a flame 31 does not contact a vial 10 to a position where the tip of the ignited point burner 30 faces an opening 16 in the outside of the vial 10, a second process of inserting the tip of the point burner 30 into an internal space 14 of the vial 10, a third process of applying the flame 31 to an inner surface 15 of the vial 10 while holding the tip of the point burner 30 in the internal space 14, a fourth process of moving the tip of the point burner 30 to the outside from the internal space 14, and a fifth process of moving the tip of the point burner 30 from the position where the tip of the point burner 30 faces the opening 16 to the standby position.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: February 4, 2020
    Assignee: NIPRO CORPORATION
    Inventors: Yoshio Inoue, Kazuhisa Moriuchi, Yoshihiro Kawai, Atsushi Ishikawa
  • Patent number: 10543318
    Abstract: A stopper includes a main body portion defining an open rearward end configured to receive the plunger rod, an engagement portion provided along an inner circumference of the main body portion configured to engage at least a top portion of the plunger rod, a closed front end forming a flexible roof, and a first perimetrical skirt extending around an outer circumference of the main body portion toward the closed front end of the main body portion. When fluid pressure is increased inside the syringe barrel during an injection, the flexible roof expands in a radial direction toward an inner wall of the syringe barrel, the first perimetrical skirt is forced against the inner wall of the syringe barrel, and an engagement between the plunger rod and the engagement portion forces the main body portion to expand in the radial direction toward the inner wall of the syringe barrel.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: January 28, 2020
    Assignee: Becton, Dickinson and Company
    Inventors: Milan Ivosevic, Girum Yemane Tekeste, Andrew Wong, Michael Vincent Quinn, Andrzej Baranski
  • Patent number: 10512721
    Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engagable with the piston regardless of a rotational orientation of the piston relative to the plunger.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: December 24, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael J. Swantner, Richard A. Seman, Barry L. Tucker, Arthur E. Uber, III, Kevin P. Cowan, James A. Dedig, Christopher D. Capone, Jaroslaw Wlodarczyk
  • Patent number: 10493207
    Abstract: The present disclosure relates to medical delivery devices that include a barrel having an inner surface, and in at least one embodiment, the inner surface is hydrophilic. The medical delivery device may further include a stopper may having an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated to the one or more fluoropolymer layers. In some embodiments, the contact angle of the inner surface of the barrel is less than about 58°. Additionally, the stopper includes a sliding surface that is less than about 2.0 mm. The barrel provides inner surface that in combination with the fluoropolymer laminate or fluoropolymer film achieve high levels of air and liquid impermeability while also maintaining an acceptably low break loose force, low average glide force, and low glide force variation. In some embodiments, the compressibility stopper against the barrel is greater than about 7.9%.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 3, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael C. Berg, Daniel H. Todd, Eric J. Van Voorhees
  • Patent number: 10493484
    Abstract: Implementations of an applicator syringe are provided. In some implementations, the applicator syringe may be configured to dispense a lubricant from a dispensing needle thereof. In some implementations, the applicator syringe may be configured so that the plunger shaft and the dispensing needle are removable when not in use. In some implementations, when the applicator syringe has been disassembled, the dispensing needle may be stored within the barrel of the applicator syringe and the plunger shaft secured about the exterior of the barrel. In some implementations, the applicator syringe may comprise a barrel having a finger flange, a plunger positioned within the interior chamber of the barrel, a plunger shaft configured to urge the plunger forward, a dispensing needle that can be removably secured to the front end of the barrel, a removable cap, and a barrel plug.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: December 3, 2019
    Inventors: Brian Keeney, David S. Giessel
  • Patent number: 10420896
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, includes an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in axial distal direction, a drive sleeve rotatably supported in the housing at least in a dose incrementing direction against the action of a spring element, and a ratchet mechanism to rotatably fix the drive sleeve relative to the housing. A first ratchet body has a first and a second ratchet element to alternately engage with a toothed profile of a second ratchet body. One of the first and second ratchet bodies is operably engaged with the housing and wherein the other one of the first and second ratchet bodies is operably engaged with the drive sleeve.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: September 24, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Wolfgang Pelzer, Björn Wilden, Philipp Zeitz
  • Patent number: 10406288
    Abstract: The invention provides a delivery mechanism for an autoinjector comprising: a first drive member configured to drive a first component in an axial direction; a second drive member configured to drive a second component in an axial direction; and a release mechanism configured to control a sequence of release of the first drive member and the second drive member, wherein the release mechanism is positioned at least partially within the first or second drive member.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: September 10, 2019
    Assignee: OVAL MEDICAL TECHNOLOGIES LIMITED
    Inventors: Dominic Charles Reber, Congyi Huang, Matthew Young
  • Patent number: 10363375
    Abstract: A pre-filled injection device includes a tubular containment body extending between a first and second openings, inside which are hermetically separated first and second containment chambers. A first substance is contained in the first containment chamber. First and second plugs inside the tubular body define the second containment chamber, and slide inside the tubular body. A second liquid substance inside the second containment chamber is intended to be mixed inside the tubular body with the first substance for reconstituting an injectable solution. A dosing reservoir has an inlet and an outlet, the inlet being in communication with the first containment chamber so that the first containment chamber extends between the first plug and the dosing reservoir inlet. The dosing reservoir contains a fraction of the injectable solution. The first plug includes a projecting appendix passing through and entering the dosing reservoir to eject the fraction of solution.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 30, 2019
    Assignee: OROFINO PHARMACEUTICALS GROUP S.r.l.
    Inventor: Ernesto Orofino
  • Patent number: 10357611
    Abstract: A closure piece for a powder syringe is proposed, having a main body, a sealing element, which is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe, when the closure piece is disposed in the closing position thereof on the powder syringe, and a channel, which passes through the main body and the sealing element and has a proximal and a distal end. The closure piece is characterized by a retaining element, which is configured and/or can be disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially, preferably completely, prevented from penetrating the channel, when the closure piece is disposed in the closing position thereof on the powder syringe.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: July 23, 2019
    Assignee: VETTER PHARMA-FERTIGUNG GMBH & CO. KG
    Inventors: Joachim Glocker, Tilman Roedle
  • Patent number: 10335539
    Abstract: Devices, systems and methods for controlling, regulating, altering, transforming or otherwise modulating the delivery of a substance to a delivery site. The devices, systems and methods optimize the delivery of the substance to an intended site, such as a vessel, vascular bed, organ and/or other corporeal structures, while reducing inadvertent introduction or reflux substance to other vessels, vascular beds, organs, and/or other structures, including systemic introduction.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: July 2, 2019
    Assignee: Osprey Medical, Inc.
    Inventors: Matthew M. Burns, Tuan M. Doan, Rodney L. Houfburg, David M. Kaye, Daniel R. Mans, Todd J. Mortier
  • Patent number: 10286151
    Abstract: A plunger seal for a drug delivery device may have a mobile and an enhanced sealing parked state. Optionally, the cartridge is stored with the plunger seal in the parked state. Optionally, drug discharge occurs with the plunger seal in the mobile state. For example in the parked state there may be increased normal force between the plunger seal and an inner wall of the cartridge. Optionally there is limited deformation of the plunger seal between the parked and mobile states. Optionally the plunger seal is biased to the parked state. Optionally, a distal force switches the plunger seal to the mobile state. For example, the plunger seal may have an inner cavity that is expanded radially by core. A biasing element optionally biases the core wedging it proximally to the parked state. A distal force on the core may push it distally to the mobile state.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 14, 2019
    Assignee: West Pharma. Services IL, Ltd.
    Inventor: Oz Cabiri
  • Patent number: 10279115
    Abstract: A syringe includes a gasket, a barrel, and a plunger. The plunger includes a helical rib provided at a head portion, and the gasket includes a threaded engagement portion configured to threadedly engaged with the helical rib, a plunger-retaining annular rib, and an accommodation portion for accommodating a part of the plunger at which the helical rib is formed. The annular rib includes a rib absent portion for guiding, to the accommodation portion, the helical rib reaching the annular rib. The gasket further includes an intermediate annular rib provided at a part on a proximal side of the retaining annular rib and a part defined on a side of the distal end of the helical projection, between a distal side annular rib and a proximal side annular rib.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: May 7, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Koichiro Furukawa
  • Patent number: 10232120
    Abstract: The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket having at least two annular projections and at least one annular valley on its sliding surface, the sliding surface being at least partially provided with immobilized polymer chains, the annular projections including a first projection nearest to the top surface and any other projection, the outer diameters of the other projection and the annular valley being in the range of 94 to 98% and 85 to 92%, respectively, with respect to the outer diameter of the first projection taken as 100%.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 19, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 10198970
    Abstract: A spinal surgery modeling system includes a spine model and a spine movement device. The spinal surgery modeling system provides a three-dimensional hands-on model that can be configured to have any desired variation of spinal alignment of the spine model by hydraulic actuation of the spine movement device to simulate the biomechanical feel and behavior of a patient's spine. The spine model may include various vertebral body or disc conditions and allows a clinician to examine and/or adjust the model and observe the three-dimensional outcome of such adjustments.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 5, 2019
    Assignee: K2M, Inc.
    Inventors: Larry McClintock, Brandon Moore, Clint Boyd, Michael Barrus
  • Patent number: 10195347
    Abstract: The auto-illuminating syringe is configured for use with a syringe. The auto-illuminating syringe is configured for use in delivering an electrolytic media. Wherein the electrolytic media is delivered into a body through the syringe. The auto-illuminating syringe increases the contrast between the electrolytic media and the background such that the electrolytic media may be more readily seen when a dose is being drawn into the syringe. The auto-illuminating syringe comprises a plunger and an illumination circuit. The illumination circuit is contained within the plunger. The plunger is configured for use in pumping fluids out of the syringe. The illumination circuit generates a distinctive light that illuminates the electrolytic media in manner that allows the electrolytic media to be readily seen. The illumination circuit is activated by the presence of the electrolytic media.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: February 5, 2019
    Inventors: Jacquelyn Berkman, Jessica Berkman
  • Patent number: 10183118
    Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: January 22, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Michael Vincent Quinn, Eric Schiller, Gang Ju, E Guan
  • Patent number: 10173013
    Abstract: Laminated gasket free from liquid drug leakage. A gasket (13) for a medical syringe, with main body (14) made of elastic material, and film (15) provided on a surface of main body (14). Gasket (13) has a circumferential surface portion (17) for contact with an inner peripheral surface of a syringe barrel (11) and an annular groove (22) formed circumferentially in a surface portion of the film in the circumferential surface portion thereof. Annular groove (22) has outer edge portions (24) provided along opposite edges (23) thereof as projecting from an unprocessed surface portion of the film. Annular groove (22) has a groove formation start point and a groove formation end point connected to each other in a groove connection region. Outer edge portions (24) provided along the opposite edges of the annular groove have a maximum-to-minimum height difference of ?5 ?m in the groove connection region.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: January 8, 2019
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Hiroyuki Kaneko, Hiroaki Nakano
  • Patent number: 10137250
    Abstract: A syringe includes a gasket, a barrel, and a plunger. The plunger includes a helical rib provided on an outer surface of a head portion, and the gasket comprises a helical valley portion for threadedly engaging with the helical rib, a plunger-retaining annular rib, and an accommodation portion for a part of the plunger at which the helical rib is formed. The annular rib comprises a rib absent portion for guiding, to the accommodation portion, the helical rib reaching the annular rib as threaded engagement is advanced between the plunger and the gasket. The helical rib comprises an entrance-restricting terminal end portion for restricting the entrance of the helical rib into the rib absent portion after the part of the plunger 4 at which the helical rib is formed is stored in the accommodation portion 32 of the gasket.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 27, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yuji Okuda, Koichiro Furukawa
  • Patent number: 10105490
    Abstract: The present invention relates to a drug delivery device for dispensing a dose of a medicament, comprising: a first housing component, and a second housing component welded with the first housing component by at least one induction heatable component.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: October 23, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Hardy Kietzmann, Matthias Scharf, Michael Scharack
  • Patent number: 10086146
    Abstract: Described are applicators having a plunger with a plunger body, and a tube having a receptacle end for insertion of the plunger, and a connector end formed of flexible plastic material having a bull-nose shape. As an example, the plunger body can include a viewing window. As another example, the connector end has an internal surface that is free of threaded connectors. The connector end can also have a snap-fit coupling design to couple to a snap-fit nozzle. The snap-fit nozzle can be connected to an adaptor cap or an administering tool of a metering dispenser.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: October 2, 2018
    Assignee: DOSELOGIX, LLC
    Inventors: Timothy Gayle Phipps, Dale Melton Coker, Daniel Lee DeYoung, Ellen Y. Brown, Saundra D. Naughton
  • Patent number: 10080882
    Abstract: A valved container assembly (10) comprising a container (12) for containing a fluid, the container (12) extending in an axial direction and having at least one venting opening (12a) at a front end and at least one dispensing opening (12b). The valved container assembly (10) further comprising a valve (14) disposed in the container (12) and a plunger element (20) disposed axially rearward of the valve (14), the plunger element (20) being axially moveable in the container (12) and defining a first volume (22) in the container (12) between the plunger element (20) and the valve (14), where the plunger element (20) is configured to increase the pressure of a fluid in the first volume (22) upon axial movement relative to the valve (14).
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: September 25, 2018
    Assignee: CONSORT MEDICAL PLC
    Inventors: Matt Ekman, Ian Anderson
  • Patent number: 10070907
    Abstract: An apparatus for bone cement delivery comprising, a proximal nozzle having a proximal end configured to couple to a bone cement source and a first distal delivery end having a circular cross section, a distal nozzle having a proximal end configured to slideably couple to the first distal delivery end and a second distal delivery end having an oblong cross section, that can be slanted, and an attachment mechanism configured to slideably retain the distal nozzle to the proximal nozzle.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: September 11, 2018
    Assignee: Biomet SAS
    Inventors: Alexis Dupuy, Sebastien Chaligne, Julie Mottet, Lenaic Giffard
  • Patent number: 10010421
    Abstract: A system and method for sharing and absorbing energy between body parts. In one particular aspect, the system facilitates absorbing energy between members forming a joint such as between articulating bones. Springs may be used to transfer loads across a joint, and can be used in conjunction with pistons and sleeves.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: July 3, 2018
    Assignee: MOXIMED, INC.
    Inventors: Joshua Makower, Anton Clifford, Richard G. Vecchiotti
  • Patent number: 9987418
    Abstract: A mechanical driver comprising a wedge shaped member operatively coupled to a shape memory alloy such that the shape memory alloy is able to displace the wedge shaped member in an essentially linear direction. The wedge shaped member is in constant contact with a lever arranged so that it can rotate about a fixed pivot point. A piston is arranged such that it is constant contact with the lever at a point between the pivot point of the lever and the contact point between the lever and the wedge shaped member. Return springs are provided to return the piston, lever and wedge shaped member to their respective start positions. Activation of the shape memory alloy displaces the wedge shaped member along its linear direction and this causes the lever to be deflected about its pivot point and the piston to be deflected in an essentially linear direction that is perpendicular to the linear direction of travel of the wedge shaped member.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: June 5, 2018
    Assignee: ViCentra B.V.
    Inventor: Joseph John Cefai
  • Patent number: 9943648
    Abstract: A closure piece for a powder syringe has a main body and a sealing element. The sealing element is disposed on the main body such that it rests in a sealing manner against a distal opening of a powder syringe when the closure piece is disposed in the closing position thereof on the powder syringe. A channel passes through the main body and the sealing element and has a proximal and a distal end. The closure piece includes a retaining element configured and/or disposed such that, prior to an activation of the powder syringe, any powder from a chamber of the powder syringe is at least substantially prevented from penetrating the channel when the closure piece is disposed in the closing position thereof on the powder syringe.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: April 17, 2018
    Assignee: VETTER PHARMA-FERTIGUNG GMBH & CO., KG.
    Inventors: Joachim Glocker, Tilman Roedle
  • Patent number: 9907912
    Abstract: A purgative product is provided which includes a gelatinous purgative and a dispenser for dispensing the gelatinous purgative. The dispenser includes a container with an open end and an opening on the opposite end. A plunger and sealing element can be inserted into the container, such that when the plunger is pushed towards the opening in the container, the gelatinous purgative between the sealing element and the opening of the container is pushed towards and out of the opening for ingestion by a user.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: March 6, 2018
    Inventor: John B. Ransome
  • Patent number: 9867946
    Abstract: The present invention aims to provide a pre-filled syringe coated with a resin film capable of reducing sliding resistance and preventing liquid leakage by a simple method. The present invention relates to a gasket for a pre-filled syringe, which has a sliding side surface that is coated with an inactive resin film and further cut to form a cut. The cut region is preferably between ring-shaped ribs on the sliding side surface, or in a ring-shaped rib on the sliding side surface.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: January 16, 2018
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Shinya Iwano, Katsushi Maeda
  • Patent number: 9855390
    Abstract: A plunger cover for use with a syringe includes a sealing portion adapted to form a seal with the syringe and a central portion adapted to contact fluid within the syringe. The central portion can, for example, be more rigid than the sealing portion. The sealing portion and the central portion are connected in an overmolding process. The sealing portion can, for example, be formed from a thermoplastic elastomer or a thermoplastic polyurethane. The central portion can, for example, be formed from polypropylene, acrylonitrile butadiene styrene, polycarbonate or copolymers thereof.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 2, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Joseph E. Bisegna, Jared E. Neff
  • Patent number: 9849248
    Abstract: A dispenser assembly is provided that has a rigid plunger with a ring-shaped protrusion. The protrusion contacts the inner wall of a flexible barrel to form a liquid-tight seal. Advantageously, the dispenser assembly does not require additional components, such as o-rings, and can be fabricated by injection molding techniques.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: December 26, 2017
    Assignee: Tessy Plastics Corporation
    Inventor: David Young
  • Patent number: 9821120
    Abstract: When a laminated gasket product is demolded from a mold in production thereof by a conventional production process, the gasket product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the gasket product. The minute scratches may impair the reliable sealability of a liquid drug. A method for producing a gasket (13) for use in a prefilled syringe (10) includes the steps of: preparing a gasket forming mold; molding a gasket (13) in the mold, the gasket having a surface laminated with a lamination film (15) and including a circumferential surface portion (17); demolding the gasket (13) from the mold, and then simultaneously forming a groove (22) and a projection (24) each extending circumferentially of the gasket in a portion of the lamination film (15) present in the circumferential surface portion (17) of the gasket.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: November 21, 2017
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Hiroaki Nakano