With Piston Or Plunger For Expelling Material From Body Or Injector Reservoir Patents (Class 604/218)
  • Patent number: 11684725
    Abstract: A disposable syringe for use with a pneumatic driver. The syringe has an elongated barrel with a cap secured to the proximal end that has a through bore. A filter is secured to the cap interior of the barrel that covers an opening in the through bore interior of the barrel. The pneumatic driver includes a source of pressurized air; a support for receiving and locating the syringe; and a supply block configured to receive pressurized air from the source and having an outlet for delivery of pressurized air. The supply block is movable between a first position spaced apart from the cap of the syringe and a second position in contact with the cap with fluid communication being established between the outlet of the supply block and the through-bore in the cap.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: June 27, 2023
    Assignee: Fenwal, Inc.
    Inventor: Robert Brown
  • Patent number: 11679205
    Abstract: A digital syringe is used with conventional polymer disposable syringe construction to be practical in the medical environment. Errors associated with the larger volumes of the syringes (which exacerbate minor errors in plunger position) and the flexibility and dimensional variations of the polymer plungers are accommodated by direct measurement of the syringe plunger position rather than indirect measurement of motor position and inference of syringe plunger position. This direct measurement eliminates mechanical tolerances (“stack up”) in the motor, gear train, and lead screw on plunger movement, an effect exacerbated by flexibility of the plunger and changes in syringe resistance and medicament viscosity, for example, with different medicaments or when the syringe is refrigerated. The digital syringe may be combined with the motor unit to provide additional versatility.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: June 20, 2023
    Assignee: Zyno Medical LLC
    Inventors: Chao Young Lee, Zhenhua Mao, Mei Zhang, Frederick Lee
  • Patent number: 11679202
    Abstract: An injector comprises a cylindrical barrel, a movable body housed in the barrel, and a plunger coming into separable contact with the movable body. The movable body includes a main body having an outer diameter smaller than an inner diameter of the barrel, a disk-shaped seal body disposed on the main body and including an outer circumferential end brought into close contact with an inner circumferential surface of the barrel, and at least one projecting portion projecting from the main body toward the inner circumferential surface of the barrel. A distance from a central axis of the movable body to a leading end of the at least one projecting portion is smaller than a half of an outer diameter of the seal body.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: June 20, 2023
    Inventors: Hideto Kasaba, Hiroyuki Kobayashi, Hiroyuki Shioi, Hiroshi Yaana, Toshiyuki Nakatsuka, Yukihiro Ogawa, Hisako Tokura
  • Patent number: 11672916
    Abstract: A supplementary device configured to be releasably attached to a distal end of a drug delivery device. The supplementary device comprising primary electronics, a non-contact acceleration sensor and a low power processor. The non-contact acceleration sensor is directed towards a proximal end of the drug delivery device and the low power processor is configured to: receive the signals output from the non-contact acceleration sensor; determine based on the signals that an outer needle cap of the drug delivery device has been removed; and in response to determining that an outer needle cap of the drug delivery device has been removed, send a wake-up signal to the primary electronics of the supplementary device.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Michael Helmer
  • Patent number: 11660398
    Abstract: The present invention relates to a stopper for an injector for delivery of a pharmaceutical composition and to an injector with the stopper. The stopper has a stopper body with an actuating surface opposite an outlet surface, an axial length between the actuating surface and the outlet surface, and a transverse diameter, which stopper body defines an access diameter, the stopper at an axial location from the actuating surface comprising a deformable sealing element surrounding the stopper body and having an outer diameter, which is larger than the transverse diameter, which deformable sealing element is made from a thermoplastic elastomer and has an axial extension in the range of 5% and 95% of the axial length of the stopper body, and the stopper comprising a cavity at the axial location of the deformable sealing element, the cavity having a lateral extension larger than the access diameter of the stopper body.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: May 30, 2023
    Assignee: INJECTO GROUP A/S
    Inventor: Mikael Hetting
  • Patent number: 11654046
    Abstract: A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 23, 2023
    Inventors: Christopher Weikart, Murray Stephen Bennett, Jean-Pierre Giraud
  • Patent number: 11654240
    Abstract: Medical devices capable of filling liquid into a syringe barrel while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel having a tapered sidewall portion for permitting air to vent from the chamber and preventing liquid from exiting the chamber, a plunger rod, and stopper. Another exemplary medical device includes a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel, a plunger rod and stopper. Also described is a medical device including a syringe barrel, plunger rod and stopper having a porous plug. Described is a medical device including a syringe barrel having a plurality of air venting grooves associated with the sidewall of the barrel and a porous membrane disposed over the air venting grooves, a plunger rod and stopper. Methods for filling a syringe barrel with a liquid are also provided.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 23, 2023
    Assignee: Becton, Dickinson and Company
    Inventor: Yiping Ma
  • Patent number: 11633543
    Abstract: In a locking device for locking a plunger rod a plunger rod locking portion is provided for locking a plunger rod of a syringe after use and preventing re-use of the syringe. A chamber is formed inside the plunger rod locking portion for receiving the disc-shaped proximal end of the plunger rod after use of the syringe. The plunger rod locking portion comprises at least one positive locking device configured to positively lock the axial position of the plunger rod by positive-fit engagement with the disc-shaped proximal end of the plunger rod and retain the disc-shaped proximal end of the plunger rod inside the chamber. The locking device provides the functionality of a tamper-evident plunger rod locking device once a dose of medication has been injected by pushing the plunger rod forward, for preventing inadvertent re-use of the syringe.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 25, 2023
    Inventor: Rishad Kairus Dadachanji
  • Patent number: 11623813
    Abstract: There is provided a syringe filled with a resin composition which prevents a barrel cap from being detached due to temperature change during storage or during transportation, a production method thereof, and a storage method thereof. This syringe filled with the resin composition includes a syringe having a syringe barrel, a resin composition filling the syringe barrel, a plunger inserted in the syringe barrel, a barrel cap blocking an opening of the syringe barrel, and a spatial part between the plunger and the barrel cap in the syringe barrel. The pressure of the spatial part in a frozen state is 50 kPa to 92 kPa.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: April 11, 2023
    Inventors: Hiroki Myodo, Masaaki Hoshiyama
  • Patent number: 11607159
    Abstract: A bodily-fluid transfer device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.
    Type: Grant
    Filed: March 31, 2022
    Date of Patent: March 21, 2023
    Assignee: Magnolia Medical Technologies, Inc.
    Inventors: Gregory J. Bullington, Richard G. Patton, Shan E. Gaw
  • Patent number: 11590517
    Abstract: An applicator for a syringe is provided that includes a hub configured to be disposed at least partially within a nozzle of the syringe and defining a fluid passage therethrough, with one or barbs on the hub that frictionally and sealingly engage an interior of the nozzle in a manner minimizing void space associated with waste of deliverable material, and an applicator tip extending distally from the hub. The barb(s) may have varying diameters in order to enable the applicator to be engaged and utilized with syringes having different diameter nozzles. Further the fluid passage through the hub and applicator tip is dimensioned to minimize the volume of material that is retained within the applicator after use, thereby increasing the volume of material that can dispensed from the syringe for use in a procedure or procedures and minimize waste.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: February 28, 2023
    Assignee: INTER-MED, INC.
    Inventors: John Baeten, Alexander D. Johnson
  • Patent number: 11577027
    Abstract: A plunger (1) for a medical delivery device comprises: a rod element (2) having a distal end (22) and a proximal end, and a stopper (3) mounted to the rod element (2) at its distal end (22). The rod element (2) has a first form fit structure (24) and the stopper (3) has a second form fit structure (31). The stopper (3) is locked to the rod element (2) by the first form fit structure (24) of the rod element (2) and the second form fit structure (31) of the stopper (3) engaging each other.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: February 14, 2023
    Inventors: Maxime Gaillot, Alan Dwyer, Pascal Launois, Julian McDonnell, Eoin Connaughton, Mark Digby Teucher, Jonathan Paul Ridley
  • Patent number: 11571520
    Abstract: A prefilled syringe includes a syringe body filled with a medical fluid, which has a nozzle at a front side, the nozzle being closed with a cap, and which is closed at a rear side with a displaceable plunger; and a plunger rod that can be inserted into the syringe body via the rear side. The plunger rod has a connecting portion at a front side, via whi9ch the plunger rod can be connected to the plunger. At least three annular elements, which extend at least in some sections about a longitudinal axis of the rod, are arranged on a rear side of the connecting portion on the plunger rod in such a manner that they are located in the syringe body when the plunger rod is fully connected to the plunger. The three annular elements support a coaxial connection of the rod to the plunger positioned in the syringe.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: February 7, 2023
    Assignee: Fresenius Kabi Austria GmbH
    Inventors: Wolfgang Baldauf, Jörg Heinrich, Christoph Zauner
  • Patent number: 11547392
    Abstract: A biological sample collection system can include (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a selectively movable valve comprising a core and a collar disposed about the core, and (iii) a sealing cap coupled to the collar and comprising a reagent chamber for storing a measure of sample preservation reagent. The sealing cap is configured to associate—and form a fluid tight connection—with the sample collection vessel such that associating the sealing cap with the sample collection vessel causes a physical rearrangement of the core relative to the collar such that a fluid vent associated with the core is moved into fluid communication with the reagent chamber, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: January 10, 2023
    Assignee: Spectrum Solutions L.L.C.
    Inventor: Neil Jeremy Johnson
  • Patent number: 11547794
    Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 10, 2023
    Assignee: Bayer Healthcare LLC
    Inventors: Michael Swantner, Richard Seman, Barry Tucker, Arthur Uber, III, Kevin Cowan, James Dedig, Christopher Capone, Jaroslaw Wlodarczyk
  • Patent number: 11541177
    Abstract: A method of adapting an auto injector configured to actuate a prefilled syringe, the auto injector having a biasing member having a spring constant, the prefilled syringe being filled with a volume of therapeutic fluid, the prefilled syringe including a barrel, stopper, and a needle, the stopper having a path of travel, the biasing member arranged to move the stopper along the path of travel. An auto injector having an injection spring adapted to an aged prefilled syringe.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: January 3, 2023
    Assignee: Teva Pharmaceuticals International GmbH
    Inventors: Paul Andrew Christopher Gibson, Edward Andrew Cummings
  • Patent number: 11517679
    Abstract: A syringe system includes a syringe and a pressurization device for a syringe. The pressurization device for a syringe is configured so that the plunger advances by a forward rotation of the plunger, and the plunger retracts by a reverse rotation of the plunger. The plunger is advanceable by pressing the gasket at the time of the forward rotation and is retractable with respect to the barrel without pulling the gasket in the proximal end direction at the time of the reverse rotation.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: December 6, 2022
    Inventors: Hiroaki Takahashi, Hitoshi Okihara, Yuki Kobarai
  • Patent number: 11517683
    Abstract: A device for positioning a needle tip to a desired location by signaling pressure change is provided. The device includes a barrel, a piston, a biasing element, and a plunger. The barrel defines a reservoir, and it includes a distal end connectable to a puncturing apparatus. The plunger is slidably engaged with the piston, and both are movable within the reservoir. The biasing element connects the plunger and the piston, and its change in length corresponds to the relative position of the plunger and piston. In operation, the piston is at a first position relative to the plunger when the biasing element is at a first length. The piston later moves to a second relative position in response to the biasing element's change of the length resulting from a pressure change inside the reservoir when the puncturing apparatus reaches a location of a mass. The position's change of the piston is visually detectable.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: December 6, 2022
    Inventor: Li-Yu Lin
  • Patent number: 11511044
    Abstract: Syringe assemblies are described herein. A syringe assembly includes an assembly housing, a first syringe, a second syringe, and a connecting gear. The first syringe is disposed within the assembly housing. Each plunger is movable within the respective syringe cavity and defines a respective chamber in the respective syringe cavity, wherein the respective chamber is in fluid communication with the respective syringe port, the respective plunger comprising a respective gear rack extending longitudinally along the respective plunger. The connecting gear is rotatably coupled to the assembly housing. The connecting gear is configured to be in meshed engagement with at least one of the first gear rack and the second gear rack of the syringes.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: November 29, 2022
    Assignee: CareFusion 303, Inc.
    Inventors: Todd Oda, George Mansour, Eugene Mason, Tomas Frausto, Dylan Beyhl
  • Patent number: 11511046
    Abstract: A method of assembling a drug delivery device, comprising the steps of: inserting a piston rod in a nut portion of a cartridge assembly and rotating the piston rod until the piston rod distal end engages the cartridge piston, mounting a drive member on the piston rod in a rota-tional position being closest to a pre-determined rotational position, and rotating the drive member to the pre-determined rotational position.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: November 29, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Daniel Knudsen, Jeppe Marckmann
  • Patent number: 11504480
    Abstract: A data collection apparatus comprises a camera configured to obtain first and second recordings of at least a portion of a medicament delivery device, said portion including a first component and a second component, the first component being configured to move relative to the second component as medicament is expelled from the medicament delivery device. The data collection apparatus also comprises a processing arrangement configured to determine, from said first and second recordings, positions in the first and second recordings of the first component relative to the second component, and determine an amount of medicament that has been expelled by the medicament delivery device by comparing the position, in the first recording, of the first component relative to the second component with a position, in the second recording, of the first component relative to the second component.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: November 22, 2022
    Inventors: Michael Schabbach, Beate Franke
  • Patent number: 11498094
    Abstract: A method of making a two-component piston, the two-component piston including a piston cover as the first component and a piston body as the second component. The piston cover is arranged adjacent to the piston body and is configured to be moved relative to the piston body.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: November 15, 2022
    Inventors: Manfred Obrist, Philipp Seiler, Renato Brunner
  • Patent number: 11478585
    Abstract: Provided is a syringe gasket including a first member, and a second member connected to the first member and coupled to a plunger rod of a syringe. The first member includes a top face contacting with the liquid, and a first side circumferential face that faces an inner circumferential face of a barrel of the syringe. The first side circumferential face has, at an end portion thereof close to the second member, a ring-like trimmed face. An inert film is laminated on the top face and the portion of the first side circumferential face other than the ring-like trimmed face. The second member includes a second side circumferential face that faces the inner circumferential face of the barrel, and a ring-like protruding portion that projects outward in the radial direction from the second side circumferential face. The ring-like protruding portion at least partially covers the ring-like trimmed face.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: October 25, 2022
    Inventors: Pederiva Marco, Protti Roberto
  • Patent number: 11473932
    Abstract: A position encoder arrangement is configured to detect the position of a movable source based on a source field, which is a magnetic field or an electric field, emitted by the source. The position encoder arrangement includes a number of sensor elements that are evenly distributed and each is configured to provide a sensor value based on the source field at the sensor element's location. The arrangement further includes an evaluation unit that is configured to determine a fine position value for the position of the movable source, and to determine from the sensor values a trustworthiness of the fine position value and/or an error flag indicating whether a failure status of the position encoder arrangement is present.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: October 18, 2022
    Assignee: AMS AG
    Inventors: Stephan Michelitsch, Gerhard Oberhoffner
  • Patent number: 11446672
    Abstract: Described are exemplary embodiments of a grasping mechanism for a powered, handheld positive displacement pipette, the grasping mechanism configured to grasp and releasably retain the piston head of a syringe that is usable with the pipette.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: September 20, 2022
    Assignee: Mettler-Toledo Rainin, LLC
    Inventors: Michael McNaul, Richard Hill, Stephen Grimwade, Michael Fairs, Vasanthan Mani, Cyril Fernandez
  • Patent number: 11439757
    Abstract: The present disclosure relates to a medical delivery device that includes a barrel having an inner surface, a plunger rod having a distal end inserted within the barrel, and a stopper attached to the distal end of the plunger rod and contacting at least a portion of the inner surface of the barrel. In at least one embodiment, the inner surface is hydrophilic. The stopper may include an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated with the one or more fluoropolymer layers. In some embodiments, the contact width between at least one rib having a sealing surface and the portion of the inner surface of the barrel measured at a compressibility of greater than about 7.9% of the stopper is less than about 1.0 mm.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: September 13, 2022
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Greg Rusch, Robert C. Basham
  • Patent number: 11419983
    Abstract: A transport assembly for shipping components of a medicament delivery device to final assembly is presented, where the transport assembly has a plunger rod, a first resilient member configured to bias the plunger rod, an elongated plunger rod holder configured to receive the plunger rod, a transport securing sleeve configured to receive a portion of the plunger rod holder, and configured to move axially from a first position relative to the plunger rod holder in which the transport securing sleeve prevents the plunger rod holder to disengage from the plunger rod to a second position located distally relative to the first position, enabling disengagement of the plunger rod holder from the plunger rod, a rear end cap, and a second resilient member configured to bear against the rear end cap and configured to bias the transport securing sleeve in the proximal direction away from the second position.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: August 23, 2022
    Assignee: SHL MEDICAL AG
    Inventors: Erika André, Pär Leander, Linda Odelberg, Anders Holmqvist
  • Patent number: 11413406
    Abstract: A tamper evident assembly for retaining a plunger and/or piston within a barrel of a syringe comprises an elongated tether disposed in an operative attachment and position on the syringe. When operatively attached, a connector assembly adjustably and fixedly interconnects the tether to an exterior of the barrel of the syringe concurrently to one end of the tether, and with a retaining member associated with the opposite end of the tether disposed in a removal restrictive relation to the plunger and/or piston, on the interior of the barrel. Movable adjustment of the tether relative to the connector assembly defines a retaining segment which can be disposed into a fixed length and taut orientation, between the ends of the tether, to further define the operative attachment or position.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: August 16, 2022
    Inventors: Jonathan J. Vitello, Timothy Brandon Hunt, Robert Banik
  • Patent number: 11400217
    Abstract: According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slidably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 2, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Yannick Hourmand, Timothy Donald Barrow-Williams, Matthew Ekman
  • Patent number: 11389590
    Abstract: The present disclosure relates to a administration assembly for a medicament delivery device, comprising: an elongated tubular delivery member cover (7), a cartridge holder (11) configured to be received by the delivery member cover (7) and configured to accommodate a medicament cartridge (31), the cartridge holder (11) having a radially flexible and radially inwards extending cartridge blocking protrusion (11b) configured to prevent the medicament cartridge (31) from moving proximally until being subjected to a proximally directed force larger than a threshold value, a needle assembly (13) comprising a double-edged needle having a proximally extending needle portion (13a) and a distally extending needle portion (13b), wherein the needle assembly (13) is configured to be assembled with the cartridge holder (11) so that the distally extending needle portion (13b) extends into the cartridge holder (11), and an administration mechanism including a plunger rod (27) configured to be proximally biased, wherein the
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 19, 2022
    Assignee: SHL MEDICAL AG
    Inventor: Oscar Alexandersson
  • Patent number: 11376369
    Abstract: A syringe including a barrel, a plunger moveably arranged within said barrel, and a plunger rod for driving said plunger. A first engagement member is arranged at the plunger rod, such that a longitudinal movement of the plunger rod yields a rotational movement of said first engagement member. The first engagement member includes a grooved surface. A second engagement member is arranged at the barrel to engage with said grooved surface of the first engagement member, wherein the first engagement member is arranged to move relative to the second engagement member, such that feedback is given to a user as the plunger rod is moved relative to the barrel for driving said plunger. The first engagement member is arranged at said plunger rod with a predetermined play there between.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 5, 2022
    Assignee: Galderma Holdings SA
    Inventors: Anders Holmqvist, Max Blomqvist, Jonas Törnsten
  • Patent number: 11364337
    Abstract: An automatic injector for delivering a pharmaceutical substance from a reservoir of a cartridge, the cartridge interconnected to a needle at its distal end and mechanically coupled to a plunger driver at its proximal end, the injector comprising a connecting feature on the cartridge a contact surface for contacting an injection site a frame connected to the contact surface, the frame having an interference element with a distal stop, the interference element sized to slidably link to the connecting feature and allow the cartridge to slide up to the distal stop, a snap element allowing the interference element to receive the connection feature, but inhibiting disconnection of the cartridge; the frame further comprising a driver mount, for fixedly containing a plunger driver, the driver for driving a plunger to empty the reservoir of the cartridge through the needle to inject fluid from the reservoir into the injection subject.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: June 21, 2022
    Assignee: West Pharma. Services IL, Ltd.
    Inventors: Oz Cabiri, Ran Hezkiahu
  • Patent number: 11364343
    Abstract: An autoinjector including a plunger for engaging with the bung, a collar located around the plunger, an insertion spring biasing the collar relative to the rear of the device, and a delivery spring biasing the plunger relative to the collar. The device further includes a stop feature defining the limit of axial movement of the syringe body through the housing, and a collar release mechanism for releasing the collar from the rear of the device to commence insertion and a plunger release mechanism for releasing the plunger from the collar while substantially preventing rearward axial movement of the collar, following insertion, to commence delivery of the medicament. Following release of the plunger from the collar, the plunger is configured to move axially and rotationally relative to the collar, the direction of rotation being changed one or more times with axial movement of the plunger.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: June 21, 2022
    Assignee: Owen Mumford Limited
    Inventor: Andrew Hung
  • Patent number: 11337628
    Abstract: A delivery device for delivering an instrument into a catheter assembly may include a syringe having a barrel and a plunger movable within the barrel. In response to depression of the plunger within the barrel, an instrument may be advanced distally. The instrument may include a catheter, a probe, a light tube for disinfection, or another suitable instrument. In response to depression of the plunger within the barrel, a distal end of the instrument may move through a catheter assembly coupled to the delivery device and into vasculature of a patient.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: May 24, 2022
    Assignee: Becton, Dickinson and Company
    Inventors: Jonathan Karl Burkholz, Derek Jewell, Joseph Spataro
  • Patent number: 11311685
    Abstract: Various implementations include a tissue lifting device that is operable using one hand. The device includes a housing, an actuator that is slidably moveable through a channel within the housing, and a lifting mechanism adjacent a distal end of the housing. The actuator causes the lifting mechanism to lift a tissue. In some implementations, the housing includes a needle adjacent the distal end of the housing that punctures the tissue and allows for injection of a composition behind the tissue. The lifting mechanism according to some implementations is a suction-based (or aspiration) system. And, in other implementations, the lifting mechanism is a grasping system.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: April 26, 2022
    Inventors: R. Rand Allingham, C. Ross Ethier, Jordan David Rehwaldt
  • Patent number: 11305060
    Abstract: An actuator for synchronized injection and aspiration, comprising: a first rod, having a length equal to an inner length between a head of a first plunger of a first standard-size syringe and a seal of the first plunger, and having a width smaller than a gap created between the first plunger and a barrel of the first standard-size syringe; a second rod, having a length equal to an inner length between a head of a second plunger of a second standard-size syringe and a seal of the second plunger, and having a width smaller than a gap created between the second plunger and a barrel of the second standard-size syringe; a flexible connector mechanically attached to a distal end of the first rod at a first end and to a distal end of the second rod at a second end.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: April 19, 2022
    Assignee: V.V.T. Med Ltd.
    Inventor: Zeev Brandeis
  • Patent number: 11285273
    Abstract: A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: March 29, 2022
    Inventors: Kevin Cowan, Michael Spohn, Michael McDermott
  • Patent number: 11278370
    Abstract: A method of operating a marking device includes defining an initial condition wherein a cannula is in an extended position and a stylet is in a ready position in the extended cannula, and, starting from the initial condition with the cannula in the extended position, sequentially: effecting movement of the stylet from a ready position to an implant position, ejecting an imaging marker through a distal opening in a cannula distal end of the cannula, and then; effecting a simultaneous unitary retraction of the cannula and stylet after ejection of the imaging marker from the distal opening in the cannula distal end.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: March 22, 2022
    Inventors: Steven E. Field, Ryan L. Goosen, Richard E. Davis, Richard M. Chesbrough
  • Patent number: 11266793
    Abstract: A syringe with high safety in use having a syringe body adapted to accommodate slidingly a plunger. The syringe body has a protruding end that is adapted to allow the mating of a base end of a needle. The syringe further includes elements for removing the needle and/or a cap interposed between the syringe body and the base end of the needle. The needle removal elements are adapted to be moved in a rotary direction for removal of the needle and/or the cap.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 8, 2022
    Assignee: Aghetto S.r.l.
    Inventor: Carlo Giuberchio
  • Patent number: 11202857
    Abstract: The subject invention provides a drug delivery device for injecting medicament which includes a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 21, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
  • Patent number: 11169058
    Abstract: Described is an automated reagent mixing container for separately storing and automatically mixing together at least two stored reagent components.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: November 9, 2021
    Inventors: Gert Blankenstein, Hansong Zeng, Jr.
  • Patent number: 11135376
    Abstract: The disclosure provides a dose controlled multi-shot injection device comprising a housing and a dose setting mechanism, wherein the dose setting mechanism includes a drive spring, a rotatable dose setting handle adapted to set a dose of medicament, thereby biasing the drive spring, and a ratchet mechanism for maintaining the drive spring in a biased state against a spring force at a set dose.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 5, 2021
    Assignee: Sanofi
    Inventor: Markus Ploch
  • Patent number: 11109785
    Abstract: A needle including a cannula having a multi-beveled point is disclosed. The multi-beveled point includes a primary bevel, two middle bevels, and two tip bevels. Each of the middle bevels extends between the primary bevel and one of the tip bevels. The primary bevel is provided on the cannula at a first angle of inclination and a first angle of rotation, the two middle bevels are provided on the cannula at a second angle of inclination and a second angle of rotation, and the two tip bevels are provided on the cannula at a third angle of inclination and a third angle of rotation. The third angle of inclination is greater than the second angle of inclination, the second angle of inclination is greater than the first angle of inclination, and the second angle of rotation is equal to the third angle of rotation.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: September 7, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Matthew Siang Si Woo, Ravi Attri, Arun U. Nair, Bo Yon Lillian Yoo
  • Patent number: 11097059
    Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: August 24, 2021
    Assignee: Owen Mumford Limited
    Inventors: Callum Davies, Abiodun Falodi, Matthew Farmer, Oliver Gould, Oliver Hyde, Parshia Moghadas, Timothy Muller, Tahir Shabudin
  • Patent number: 11083846
    Abstract: Disclosed are syringes that allow one-handed operation for measuring and dispensing a medicament, provide consistent finger placement on the syringe barrel. The syringes have a generally oval exterior shape that comfortably fits a user's hand and prevents rolling of the syringe when placed on a surface. Due to the shape of the syringes, the dispensing tip will not touch a surface or substrate when the syringe is placed thereon, providing improved hygiene and reduced contamination. The syringes preferably have a dosage marking on the barrel that provides ease of seeing the withdrawn medicament. The dosage marking can be raised and/or colored and/or made light sensitive. The raised markings can provide an audible and/or tactile indication of the dose of medicament drawn into or out of the syringe.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 10, 2021
    Assignee: GlaxoSmithKline Consumer Healthcare (UK) IP Limited
    Inventors: George Cave, Paul Richard Draper, Daniel Paul Salisbury
  • Patent number: 11058829
    Abstract: An injection device is used for “tattooing” markers inside the heart of a patient at specific locations. Placement within the heart of markers, such as points marked with a radiopaque dye, may reduce the use of x-ray dye and echocardiography, may allow a quicker cardiac procedure, and thus may improve the procedure outcome for the patient. Alternatively or additionally to cardiac marking with a radiopaque dye, cardiac tissue fibrosis, cardiac tissue contraction, and/or cardiac tissue stiffening (or hardening) can be promoted at specific locations by delivering a suitable substance.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: July 13, 2021
    Inventors: Michael B. McDonald, Shalaka V. Bapat
  • Patent number: 11052197
    Abstract: A prefilled injection pen for injecting insulin, the prefilled injection pen including: a screw rod, a memory connection barrel, a fixed barrel and a rotating barrel. A plurality of first one-way teeth is evenly distributed on an end surface of the rotating barrel. The memory connection barrel is disposed inside the rotating barrel. The inner wall of the memory connection barrel is provided with a protrusion matching a thread of the screw rod. An end face of one end of the fixed barrel is provided with a ratchet pawl matching the first one-way teeth. The fixed barrel is also provided with a first inner thread matching the screw rod. The screw rod is provided with two machined plane surfaces. A plunger is disposed at one end of the screw rod and a stopper is disposed in a thread groove at the other end of the screw rod.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: July 6, 2021
    Inventor: Chunsheng Wang
  • Patent number: 11033684
    Abstract: A single-use auto-injector includes a housing and a dosing unit in at least part of the housing. The dosing unit includes a needle, a drug container with drug, a piston movable in the container, a first mechanical power supply for moving the piston to deliver the drug, an activation mechanism, and a mechanical escapement mechanism for controlling the movement of the piston. The auto-injector has a first state in which the needle is protected from needle damage or contamination, a second state in which the needle is ready to penetrate a human body, a third state in which the needle has penetrated the human body and is ready to dose, and a fourth state in which the needle is shielded to avoid unintended needle sticks. A second mechanical power supply is configured to shift state of the auto-injector from the third state to the fourth state.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 15, 2021
    Assignee: AMGEN INC.
    Inventors: Hans Stenberg Knudsen, Christian Plambech, Rasmus Øhlenschlæger, Jørgen Jørgensen
  • Patent number: 11020527
    Abstract: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 1, 2021
    Assignee: ALK-ABELLÓ A/S
    Inventor: Jens Mikkelsen
  • Patent number: 10987505
    Abstract: A fluid connector assembly is disclosed. The fluid connector assembly includes a body portion, a plug portion located on the body portion, the plug portion comprising a fluid path, a tubing, a first end of the tubing fluidly connected to the plug fluid path, a catch feature located on a first end of the body portion and configured to interact with a reservoir, and a latching feature located on a second end of the body portion, the latching feature configured to interact and lock onto the reservoir.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: April 27, 2021
    Assignee: DEKA Products Limited Partnership
    Inventors: Richard J. Lanigan, Gregory R. Lanier, Jr., Kevin L. Grant, Dean Kamen, Lisa A. Panneton, Bright C. K. Foo, Stephen L. Fichera, Thomas F. Soldau, David D. B. Cannan