Liquid Stream Passes Through Reservoir Containing Treating Material Patents (Class 604/85)
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Publication number: 20110282324Abstract: A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.Type: ApplicationFiled: May 13, 2010Publication date: November 17, 2011Inventors: Takashi Kurokawa, Christopher W. Widenhouse, Agnieszka Seyda, Jeffrey S. Swayze, Foster B. Stulen, Mark H. Ransick, Richard W. Timm, Shailendra K. Parihar, Shelby L. Cook Kornbluth
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Patent number: 8002734Abstract: A double chamber container for holding and combining a solid lyophilizate and a liquid reconstituting medium, comprising a cylindrical body with a closure at each of the two ends, an upper displaceable closure at the reconstituting medium end, and a lower closure at the lyophilizate end, a separating stopper that can be pushed in the cylindrical body and act as a seal between the upper chamber and the lower chamber, and a bypass arranged underneath the separating stopper, with a length L that is preferably greater than the height H of the separating stopper, wherein at the upper end in the wall of the cylindrical body or in the separating stopper means are provided that allow partial connection of the interior of the cylindrical body to the environment during the lyophilization.Type: GrantFiled: August 14, 2006Date of Patent: August 23, 2011Assignee: Boehringer Ingelheim International GmbhInventors: Stefan Bassarab, Alexander Bauer, Nicole Denkinger, Patrick Garidel, Markus Hemminger, Hans-Hoachim Kern, Andreas Langer, Ingo Presser
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Publication number: 20100292672Abstract: A syringe includes a cartridge and a second chamber. The cartridge includes a first chamber, a first end having a conduit in liquid communication with the first chamber, a liquid disposed within the first chamber, a second end moveable within the first chamber, and a locking mechanism. The conduit is adapted and configured to rely on a property of the liquid to prevent movement of the liquid out of the first chamber. The locking mechanism is adapted to prevent movement of the second end within the first chamber while in the locked configuration. The cartridge is moveable within the second chamber.Type: ApplicationFiled: July 9, 2010Publication date: November 18, 2010Inventor: Martin N. Lee
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Publication number: 20100249753Abstract: A vented syringe system and method for particulate containment, mixing and delivery, the system having a vented syringe containing particulate material structured to enable entrapped gases to escape during the injection of liquid into the particulate material, such that gas is removed from the vented syringe prior to ejection of the wetted particulate material.Type: ApplicationFiled: February 25, 2010Publication date: September 30, 2010Inventors: David M. Gaisser, Srinivas Katta
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Publication number: 20100228189Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.Type: ApplicationFiled: April 8, 2010Publication date: September 9, 2010Applicant: LABORATOIRE AGUETTANTInventor: Pierre FREZZA
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Patent number: 7780621Abstract: A blood chamber for an extracorporeal blood circuit comprises a blood inlet port (2), a blood containment chamber (3), a first conduit (8) which connects the blood inlet port (2) with the blood containment chamber (3) and which has an end tract (8a) that terminates in the blood containment chamber (3) with a horizontal inlet component. The first conduit (8) comprises a pre-terminal tract (8b) which precedes the end tract (8a) and which has at least a second horizontal component which is directed in an opposite direction to the horizontal inlet component. The blood chamber is used in an arterial line of a dialysis set for guaranteeing a regular and gentle blood flow.Type: GrantFiled: July 6, 2005Date of Patent: August 24, 2010Assignee: Gambro Lundia ABInventors: Robert Neri, Andrea Paltrinieri
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Patent number: 7776010Abstract: A hollow inner plunger for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a proximal end and a distal end. A sealing plug and rupturable membrane are disposed at the distal end of the body, and the sealing plug and rupturable membrane are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow inner plunger as described above, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow inner plunger, and the hollow inner plunger is slidably disposed within the syringe barrel. The two components are initially separated by the rupturable membrane.Type: GrantFiled: February 9, 2007Date of Patent: August 17, 2010Assignee: Ultradent Products, Inc.Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
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Patent number: 7749191Abstract: Devices and methods of delivering a known quantity of a substance are provided. In particular, a substance delivery device is provided having a cartridge containing a known amount of the substance that is removably attachable to a pressure source such that substantially all of the amount of the substance is discharged from the cartridge upon actuation of the pressure source. The devices and methods provided are particularly applicable to the delivery of a drug or medicament.Type: GrantFiled: March 20, 2008Date of Patent: July 6, 2010Assignee: Beutlich LP, PharmaceuticalsInventor: Pamela Truax
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Patent number: 7726362Abstract: A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet port for the container. The container assembly may be received within a receiving chamber for causing the coupling. The solution may be permitted to flow out of the outlet port when the solution rises within the container to a level of the outlet port so that the substance is partially diluted before flowing out of the outlet port.Type: GrantFiled: October 29, 2007Date of Patent: June 1, 2010Assignee: DEKA Products Limited PartnershipInventors: Jason A. Demers, James D. Dale, Brian Tracey, David W. McGill, Larry B. Gray
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Patent number: 7699811Abstract: A pre-filled syringe including a barrel 1, a base end gasket 4 which is fluid-tightly slidable in the barrel 1, a front end gasket 8 which is fluid-tightly slidable in the barrel 1, and a nozzle part 2 provided in a front end of the barrel 1, wherein the nozzle part 2 includes a front end gasket accommodation part 23 which is capable of accommodating the front end gasket 8, and liquid flow passages 21 extending in an axial direction in an inner periphery wall, through which a liquid medicine can pass when the front end gasket 23 is accommodated in the front end gasket accommodation part 23, and a sectional area of a front end of the liquid flow passages 21 is smaller than a sectional area of a base end.Type: GrantFiled: January 11, 2007Date of Patent: April 20, 2010Assignee: Nipro CorporationInventor: Mitsuru Hasegawa
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Patent number: 7678073Abstract: An automatic injector separately stores liquid and dry components in respective compartments. When the injector is activated, a fluid-directing member between the liquid and dry compartments causes the liquid component to form a vortex as the liquid flows into the dry compartment. This allows the two components to combine more thoroughly and quickly to form a liquid solution that is delivered to an injection site.Type: GrantFiled: August 29, 2007Date of Patent: March 16, 2010Assignee: Meridian Medical Technologies, Inc.Inventors: Steven M. Griffiths, Robert L. Hill, Matthew P. Robben
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Publication number: 20100056998Abstract: A dispensing device for dispensing medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.Type: ApplicationFiled: December 17, 2008Publication date: March 4, 2010Inventors: Marshall S. Kriesel, Joshua W. Kriesel, Donald B. Bivin, Alan D. Langerud, Thomas N. Thompson
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Publication number: 20100056996Abstract: A dispensing device for dispensing medicaments to a patient that is made up of first and second stand-alone, interconnectable assemblies. The first of these assemblies comprises a fluid reservoir assembly that houses a fluid reservoir defining component while the second assembly comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first assembly toward the patient via a plurality of fluid flow control passageways. Because the stand-alone fluid delivery and control assembly is initially totally separate from the fluid reservoir assembly of the apparatus, the fluid flow passageways of the fluid delivery and control assembly can be effectively sterilized using conventional gamma ray sterilization techniques without adversely affecting the medicament contained within the fluid reservoir of the apparatus.Type: ApplicationFiled: September 3, 2008Publication date: March 4, 2010Inventor: Marshall S. Kriesel
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Publication number: 20100056997Abstract: A dispensing device for dispensing medicaments to a patient that includes first, second and third stand-alone, inter-connectable assemblies. The first of these assemblies comprises a fluid delivery and control assembly that includes a novel flow control assembly that functions to control the flow of medicinal fluid from the fluid reservoirs of the first and second assemblies of the invention toward the patient via a plurality of fluid flow control passageways. The second and third stand-alone reservoir defining components, which are interconnected with the fluid and delivery control component, each include an integrally formed, hermetically sealed collapsible container and a spring for controllably collapsing the container.Type: ApplicationFiled: December 17, 2008Publication date: March 4, 2010Inventor: Marshall S. Kriesel
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Patent number: 7611480Abstract: An in-vivo bioreactor device producing a dialysis effect by acting within the gastrointestinal tract for the removal of undesirable concentrated intestinal or blood substances or metabolites is disclosed. The ingestible device is comprised of a body wall that surrounds an internal compartment. Along the wall of the shell are openings located around the periphery that allow bodily fluids to enter and exit device. The wall of the device is comprised in whole or at least in part of materials that are impermeable to the passage of external fluids and maintains its physical and chemical integrity in the environment of use during its activity. Semi-permeable membranes located either internally or externally of the device are able to withstand all physiological temperatures and pH and act in a similar manner to dialysis membranes that are used for the separation of substances in suspensions, solutions, tissue cultures, etc.Type: GrantFiled: April 24, 2003Date of Patent: November 3, 2009Inventor: Mark M. Levy
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Publication number: 20090240196Abstract: Devices and methods of delivering a known quantity of a substance are provided. In particular, a substance delivery device is provided having a cartridge containing a known amount of the substance that is removably attachable to a pressure source such that substantially all of the amount of the substance is discharged from the cartridge upon actuation of the pressure source. The devices and methods provided are particularly applicable to the delivery of a drug or medicament.Type: ApplicationFiled: March 20, 2008Publication date: September 24, 2009Applicant: Beutlich LP, PharmaceuticalsInventor: Pamela Truax
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Patent number: 7584872Abstract: A fluid dispensing device includes a pressurizing device coupled between a fluid bottle and a discharge tube for forcing the fluid to flow through the discharge tube without gravity, the pressurizing device includes a container having an inclined inner peripheral surface, and a piston slidably received in the container and having an outer peripheral portion for selectively engaging with the inclined inner peripheral surface of the container in order to pump the fluid into the discharge tube when the piston is moved toward the discharge tube, and for being selectively disengaged from the inner peripheral surface of the container when the piston is moved away from the discharge tube.Type: GrantFiled: March 3, 2009Date of Patent: September 8, 2009Inventor: Samw Hong Jen Wang
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Publication number: 20090118696Abstract: Methods for delivery of a compound within a tube.Type: ApplicationFiled: October 31, 2007Publication date: May 7, 2009Inventor: Eldon H. Nyhart, JR.
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Publication number: 20090099547Abstract: A transfer system (100, 100?, 100?) adapted to allow first contents of a first container (20) and second contents of a second container (30) to mix to form a material. The mixed material is retrieved to a syringe (40). The transfer system (100, 100?, 100?) comprises first (17) and second (18) flow control members for controlling fluid flow between the containers (20, 30) and the syringe (40). The invention further relates to a drug mixing kit comprising a container unit containing first and second containers, and a transfer unit comprising ports for receiving the containers and a syringe and a number of flow channels. The container unit and the transfer unit are adapted to be coupled together to form a drug mixing kit.Type: ApplicationFiled: April 23, 2007Publication date: April 16, 2009Applicant: Novo Nordisk A/SInventor: Bo Radmer
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Patent number: 7516873Abstract: A fluid dispensing device includes a fluid bottle, a discharge tube, a pressurizing device coupled between the bottle and the discharge tube for forcing the fluid to flow through the discharge tube without gravity, the pressurizing device includes a container coupled between the bottle and the discharge tube, a piston is slidably received in the container, and a motor is coupled to the piston to move the piston in the reciprocating action within the container, and a speed reduction device is coupled between the motor and the piston for allowing the piston to be actuated by the motor with a reduced driving speed and an increased driving torque.Type: GrantFiled: July 11, 2007Date of Patent: April 14, 2009Inventor: Samw Hong Jen Wang
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Publication number: 20090088724Abstract: Multiple stage fluid delivery devices are provided for dispensing a first fluid at a first flow rate and thereafter dispensing a second fluid at a second flow rate which is substantially lower than the first flow rate. The device may be used to inject a fluid into a catheter to flush the catheter and to thereafter slowly deliver fluid into the catheter to maintain patency of the catheter.Type: ApplicationFiled: September 24, 2008Publication date: April 2, 2009Applicant: Tyco Healthcare Group LPInventors: Casey Chebator, Michael Sansoucy
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Publication number: 20090036823Abstract: A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.Type: ApplicationFiled: July 30, 2008Publication date: February 5, 2009Inventor: Patrick LePivert
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Publication number: 20090024082Abstract: Time-indicating syringe mixing systems for mixing, storing, and dispensing a two-part dental composition that becomes less stable upon mixing including a first plunger comprising an elongate stem and a plug at a distal end of the elongate stem, a hollow first chamber configured to contain a first component, a hollow second chamber configured to contain a second component, and means for indicating a recorded date when a first component initially contained within the hollow first chamber is mixed with a second component initially contained within the hollow second chamber. The inventive syringe mixing systems may be configured as syringe-in-syringe systems and/or syringe-to-syringe systems.Type: ApplicationFiled: September 30, 2008Publication date: January 22, 2009Applicant: ULTRADENT PRODUCTS, INC.Inventors: Bruce S. McLean, Dan E. Fischer, Neil Jessop
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Patent number: 7455658Abstract: A fluid dispensing device includes a bottle for receiving fluid, a discharge tube, and a pressurizing device coupled between the bottle and the discharge tube, for pressurizing the fluid and for forcing the fluid to flow through the discharge tube without gravity. The pressurizing device includes a container coupled between the bottle and the discharge tube, a piston slidably received in the container, and a moving device for moving the piston in a reciprocating action within the container. For example, a motor is coupled to the piston with a crank, to move the piston in the reciprocating action within the container.Type: GrantFiled: November 10, 2004Date of Patent: November 25, 2008Inventor: Samw Hong Jen Wang
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Publication number: 20080243062Abstract: An infusion set kit includes an infusion set and a cannula insertion device. The infusion set has an infuser base configured for adhesive attachment to an infusion site on a user's skin, a cannula cartridge configured for operative engagement with the infuser base, and a hub configured for user-controlled 360 degree (360°) rotary engagement with the infuser base.Type: ApplicationFiled: April 27, 2007Publication date: October 2, 2008Inventors: Mark A. DeStefano, Paul Tashjian, Steven E. Wojcik, Jeff Kiersh
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Publication number: 20080228124Abstract: The present invention relates to materials, coatings, apparatus, and methods for removing radiocontrast agent from a patient. In accordance with one aspect of the invention, molecular imprinting technologies are utilized to create a safe, predictable and reliable medium for removal of nephrotoxic contrast agent from body fluids of a patient, such as the bloodstream. In accordance with certain aspects of the present invention, the contrast agent can be removed without mechanical filtering or any other mechanically damaging technique affecting the blood matrix. The molecularly imprinted medium (MIM) can be used to extract the contrast agent from the blood either intra- or extracorporeally.Type: ApplicationFiled: February 15, 2008Publication date: September 18, 2008Applicant: ATLA HOLDINGS, LLCInventors: Gregory Lamps, Jay Yadav, Boris Mizaikoff
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Patent number: 7425207Abstract: A vial for dispensing a liquid into a syringe is described which comprises a body section for holding the liquid, the body section having a top and a bottom; a port having a removable seal, where the port is adapted for a syringe connection and where the port is interconnected with the body section at a point near the top of the body section by a passageway which for at least a portion of its length extends above the level of the liquid in the body section when the vial is inverted, thereby preventing leakage of the liquid from the body section when the seal of the port is removed. A method of making the vial is also described.Type: GrantFiled: June 13, 2005Date of Patent: September 16, 2008Assignee: Holopack International Corp.Inventors: Shawn W. Miller, David Rocheleau, Mohammad R. Sadeghi, Walter Zahn, Bernd Hansen
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Publication number: 20080208117Abstract: An infusion system utilizes a solution reservoir divided into a first section and a second section which are fluidly isolated but volumetrically connected such that introduction of a pumping fluid into the first section of the reservoir causes displacement and flow of a solution out of the second section of the reservoir. The use of a separate reservoir, separation member, and delivery tubing allow for significantly decreased loss of feeding solution and the like due to dead volume.Type: ApplicationFiled: October 19, 2007Publication date: August 28, 2008Inventors: Christopher P. Steinman, Jason A. Bultman
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Publication number: 20080195082Abstract: The present invention relates to a syringe for storage, mixing and dispensing of multi-component paste materials, and more precisely to a syringe for two or more components of a paste material which are to be mixed together.Type: ApplicationFiled: June 3, 2005Publication date: August 14, 2008Inventors: Helmut Pauser, Michael Knee, Ingo W. Wagner
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Patent number: 7407494Abstract: A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the piston to exert a force on the components, a first holding element for holding the piston in a force-loaded state, and at least one activator for releasing the piston, a second holding element for stopping the piston when it has moved a certain first distance after one activation of the at least one activator and holding the piston in that position, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix.Type: GrantFiled: January 31, 2005Date of Patent: August 5, 2008Inventors: Anders Boström, Stefan Loof
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Publication number: 20080171972Abstract: The present disclosure provides a medical device package including a container for receiving a medical device having an area configured for storing at least one agent and a port for permitting the passage of a contact material between the outside the container and the area configured for storing the agent.Type: ApplicationFiled: October 6, 2006Publication date: July 17, 2008Inventor: Joshua B. Stopek
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Publication number: 20080125725Abstract: The invention is a medical device for containing and/or dispensing a therapeutic agent or a placebo to a patient. The medical device is preferably a syringe or an intravenous (IV) infusion system. A device according to the invention has a viewing portion through which a therapeutic agent or placebo contained therein may be seen by a patient or operator. The viewing portion is colored so that a therapeutic agent having a first color and a placebo having a second color that is different from the second color are virtually or entirely indistinguishable when contained within the device and viewed through the viewing portion.Type: ApplicationFiled: August 4, 2006Publication date: May 29, 2008Inventor: Nabil Dib
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Publication number: 20080125759Abstract: An implantable drug delivery system includes an infusion pump assembly with a fluid outlet, a fluid delivery pathway extending from the pump outlet to a target tissue site; and a controlled release material unit positioned in the fluid delivery pathway to release a drug or bioactive material into the delivery pathway. The pump assembly delivers fluid as a high flow infusion flow in said pathway, entraining drug material released by the release unit and establishing a pressure gradient at the distal end of the pathway that results in convection-enhanced transport such that the released drug(s) or treatment material enter the target tissue site with enhanced penetration depth and/or concentration. The pump delivers a carrier fluid that may reside in an external or in an implanted reservoir, or that may be an endogenous fluid, such as plasma or CSF.Type: ApplicationFiled: February 1, 2008Publication date: May 29, 2008Applicant: CODMAN & SHURTLEFF, INC.Inventors: David D. Konieczynski, Alan J. Dextradeur, William L. Rohr
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Publication number: 20080021381Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.Type: ApplicationFiled: July 20, 2007Publication date: January 24, 2008Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.Inventors: Kent L. LURVEY, Shmuel STERNBERG, Vadim V. KRONGAUZ, Rosa H. YEH, Robin G. PAULEY, Dustin C. CAWTHON, Ton That HAI, Lecon L. WOO, Ashok K. KHANNA, Birendra K. LAL, Michael Tung-Kiung LING, William S. HOERLE, Craig L. SANDFORD, Mark A. NORDHAUS, Alexander SAVITSKI, Nicklaus J. KIRICHKOW, Kenneth Glen SUH, Sivaramakrishnan KRISHNAMOORTHY, Hsinjin E. YANG, Robert A. CLARKE
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Patent number: 7311692Abstract: A dual-chamber type prefilled syringe comprises a cylindrical body within which a front plug member, a middle plug member and an end plug member are hermetically fitted to form a first chamber and a second chamber. The cylindrical body has an inner surface formed with a bypass. When the middle plug member moves to a position where the bypass is formed, the first chamber is communicated with the second chamber for the first time via the bypass. In this beginning state of liquid transfer (S), an inner volume (VS) of the cylindrical body between a leading end of the cylindrical body and a rear end of the front plug member is set to be at least 60% of a volume (VC) of a second component. When liquid component within the second chamber flows into the first chamber, it is possible to prevent part of the liquid component from passing through the first chamber to reach a portion for attaching an injection needle at a leading end of the cylindrical body.Type: GrantFiled: February 18, 2004Date of Patent: December 25, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Masahiko Kato, Yasaburo Akagi
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Patent number: 7250619Abstract: The disclosure below relates to apparatus and methods for producing medicament using sub-optimal water sources. One embodiment of the disclosure is directed to an apparatus comprising a preliminary purification component, a disinfection component, a pharmaceutical grade water preparation (PGW) component, and a drug pack. Another disclosed embodiment relates to a method for producing a peritoneal dialysis solution, comprising, passing diluent through a preliminary purification component, passing diluent through a disinfection component, passing diluent through a PGW preparation component, passing diluent through a drug pack, and collecting solute produced by the drug pack.Type: GrantFiled: May 14, 2002Date of Patent: July 31, 2007Assignees: PrisMedical Corporation, Water Health International, Inc.Inventors: Michael A. Taylor, Mark L. Sizelove, Tralance O. Addy
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Patent number: 7214210Abstract: A disposable cassette for mixing an intravenous drug in a vial to a patient includes a liquid inlet for connection to a liquid supply, a first vial spike, a second vial spike and a chamber. The chamber, the first and second vial spikes, and the liquid inlet are in fluid communication with each other. A valve mechanism may be actuated to control flow between the chamber, the vial receptacles and the liquid inlet.Type: GrantFiled: March 16, 2004Date of Patent: May 8, 2007Assignee: DEKA Products Limited PartnershipInventors: Dean Kamen, Charles M. Grinnell, Marc A. Mandro, Dennis Gilbreath, Kevin Lee Grant, Jason A. Demers, William T. Larkins, Robert Manning, Richard J. Lanigan
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Patent number: 7182748Abstract: A syringe, for use in the delivery of a dose of a therapeutic agent entrained within a pressurized fluid flow, includes an upstream portion, an intermediate portion, a downstream portion, and an actuator mechanism for initiating a flow of the fluid through the syringe. The upstream portion is interfaced with a source of fluid under pressure. The intermediate portion, which is interposed between the upstream and downstream portions, includes first and second members that are coupled together to provide a closed pocket for containing the dose. One of the first and second members is moveable relative to the other within the syringe to provide an open configuration in which the pocket is opened to expose the dose for entrainment by the fluid as it flows through the intermediate portion and to and through the nozzle. Also provided is a capsule formed from the first and second members.Type: GrantFiled: July 6, 1998Date of Patent: February 27, 2007Assignee: PowderJect Research LimitedInventors: Charles Potter, David Stuart Potter, Brian Bellhouse, John Christopher Greenford, Fiona Carter, Stuart Graham Weekes, Colin Sheldrake
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Patent number: 6916305Abstract: Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed.Type: GrantFiled: January 8, 2003Date of Patent: July 12, 2005Assignee: Prismedical CorporationInventors: Eugene C. Jones, Michael A. Taylor
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Patent number: 6878338Abstract: A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.Type: GrantFiled: May 6, 2002Date of Patent: April 12, 2005Assignee: Prismedical CorporationInventors: Michael A. Taylor, Carolyn Fitzgerald
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Patent number: 6846300Abstract: The multi-component mixing capsule with dispensing device has a container part in which a component can be accommodated. A further component is arranged in a piston which is sealed at one end by a foil disk and a holed disk. At the other end, the piston is sealed by a ram which, in a first operating step, forces the liquid component from the piston into the mixing space of the container part and, in a second operating step, also forces the piston downward so that the mixed compound can emerge from the dispensing device.Type: GrantFiled: March 13, 2003Date of Patent: January 25, 2005Assignee: Ernst Muhlbauer GmbH & Co. KGInventors: Hans Hörth, Matthias Jürgens
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Patent number: 6835181Abstract: The disclosed apparatus comprises a valve, a container, first and second coupling devices, a hose, and a jet tip. The valve directs water flow from the faucet to the first coupling device that releasably locks the valve in communication with the container. The water flow travels into the container to mix with oral hygiene substance to produce a liquid mixture. The second coupling device releasably locks the container in communication with the hose to receive and channel the liquid mixture to the jet tip at the hose's opposite end for generation of a spray jet useful in oral hygiene.Type: GrantFiled: March 29, 2002Date of Patent: December 28, 2004Inventor: Joseph B. Hippensteel
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Patent number: 6817987Abstract: A syringe holding a solvent and a soluble component has a tubular body formed its front and rear ends with a bypass, a plunger axially slidable in the body, and a stem projecting axially rearward out of the body from the plunger. A cover fits over the front end of the body and is so tight that the front compartment can be pressurized to a superatmospheric pressure without leakage out the front end. A free piston slidable in the body forward of the plunger subdivides the body forward of the plunger into a front compartment at the front body end holding the soluble component and a rear compartment between the plunger and the piston and holding the solvent. Stops are provided for arresting the free piston when it is level with the bypass in a position permitting flow through the bypass between the compartments.Type: GrantFiled: August 16, 2002Date of Patent: November 16, 2004Assignee: Arzneimittel GmbH Apotheker Vetter & Co. RavensburgInventors: Udo J. Vetter, Thomas Otto
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Patent number: 6805685Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.Type: GrantFiled: November 12, 2003Date of Patent: October 19, 2004Assignee: PrisMedical CorporationInventor: Michael A. Taylor
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Patent number: 6770051Abstract: A device and method for providing a suspended agent such as a contrast agent without mechanical resuspension. A volume of agent (12) is divided into sub-volumes in a network (8) of tubes (18), cells (42), sponges (44), grooves (48), etc. A propellant fluid (16) flows through the network (8) to release the suspended agent (12). The network (8) may be internal to a container (10) for the propellant fluid (16). Alternatively, the network (8) may be adjacent an exit port (24) of a container (10) for the propellant fluid (16), or may be in-line between a propellant fluid container (10) and a patient. The invention reduces sedimentation of agents into one or a few aggregates and eliminates a mechanical mixing step. The invention thus provides a uniformly suspended agent, improving patient health and safety and increasing cost and time savings.Type: GrantFiled: July 30, 2001Date of Patent: August 3, 2004Assignee: Mallinckrodt Inc.Inventors: Michael Scott Hughes, William Hagen, Brian Doty, Gordon Persaud
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Publication number: 20040097874Abstract: A separation assembly for a container for separating a first component from a second component is disclosed. The separation assembly includes a generally cylindrical body that is constructed and arranged to be slidably supported within a container between a liquid component and a dry component. The body includes a seal structure constructed and arranged within the container between the first component and the second component. The seal structure has an inner seal member wherein the inner seal member is initially in a sealing condition that maintains the first component sealed from the second component. The inner seal member being converted to a mixing condition in response to the predetermined operating condition such that the first component flows through at least one flow path in the seal structure to mix with the second component.Type: ApplicationFiled: September 3, 2003Publication date: May 20, 2004Applicant: MERIDIAN MEDICAL TECHNOLOGIES, INC.Inventors: Steven Griffiths, Robert L. Hill, John G. Wilmot
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Patent number: 6702778Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a dry compartment located within a housing for storing a predetermined dry charge of the medicament therein, a wet compartment within the housing for storing a predetermined amount of liquid injection solution therein, an activation assembly for causing the liquid injection solution in the wet compartment to be transferred to the dry wet compartment, and at least one compression assembly for maintaining the medicament located in the dry compartment under a continuous compressive state as the liquid injection solution passes through the dry compartment.Type: GrantFiled: June 8, 2001Date of Patent: March 9, 2004Assignee: Meridian Medical Technologies, Inc.Inventors: Robert Leavitt Hill, Maria Cristina D'Erasmo, John G. Wilmot, Gerald L. Wannarka
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Patent number: 6676632Abstract: An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.Type: GrantFiled: February 3, 2003Date of Patent: January 13, 2004Assignee: PrisMedical CorporationInventor: Michael A. Taylor
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Publication number: 20030176834Abstract: The multi-component mixing capsule with dispensing device (2) has a container part (1) in which a component can be accommodated. A further component is arranged in a piston (4) which is sealed at one end (5) by a foil disk (6) and a holed disk (7). At the other end, the piston (4) is sealed by a ram (8) which, in a first operating step, forces the liquid component from the piston (4) into the mixing space of the container part (1) and, in a second operating step, also forces the piston (4) downward so that the mixed compound can emerge from the dispensing device (2).Type: ApplicationFiled: March 13, 2003Publication date: September 18, 2003Applicant: Ernst Muhlbauer GmbH & Co. KGInventors: Hans Horth, Matthias Jurgens
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Patent number: 6595951Abstract: The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.Type: GrantFiled: May 19, 2000Date of Patent: July 22, 2003Assignee: Alza CorporationInventors: Patrick S. -L. Wong, James Horvath, Radomir N. M. Vukadin, Joyce C. Anthony, Vincent J. Ferrari, Jeffrey W. Etter, Christopher M. G. Ohms