Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for parenteral use including intravenous delivery for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A cartridge 444, 644, 744 is adapted for mounting upon a receptacle 442, 642 in a parenterial fluid administration set 420 for delivering a drug or other beneficial agent to a patient. The cartridge 444, 644, 744 includes a beneficial agent-containing chamber 606 slidable from a first, pre-use position to a second, post-use position. The cartridge includes a hollow tube 496 in which the chamber 606 is at least partially mounted. At least one cannula 500 is mounted to the hollow tube and extends opposite the chamber. A protective cover or cap 530 maintains a chamber protective position that prevents inadvertent movement of the chamber that would accidentally engage the cartridge chamber with a flow path member, such as the cannula. The cover is removed in order to engage the chamber.

Abstract: The desired invention concerns a syringe with a double compartment. The first compartment (10) is bounded by a first cylinder (12), closed off at one end by a first partition (13) in which an opening (15) is provided, and at its other end by a first sliding piston (14). This syringe also contains a second cylinder (17) coaxial to and inside of the first cylinder, attached at its first extremity to the first piston and closed of at its second extremity by a second partition (18), and an axial rod (16), coaxial to and inside of the secnd cylinder, that is attached to the first partition by its first extremity, sliding across the first piston (14) and supporting at its other extremity a second piston (19) that slides into the second cylinder. In this manner, a second compartment is formed by the second cylinder, the second piston, and the second partition, the volumes contained in the two compartments fluctuating simultaneously when the second cylinder is shifted in relation to the first one.

Abstract: A needle-pierceable cartridge for drug delivery comprises a housing containing a drug-containing bag having wallls of hydrophilic material capable of diffusing water across the walls, whereby osmosis can take place. The bag walls also define macroscopic holes, so that water on the outside of the bag diffuses by osmosis into the bag, and osmotic pressure forces water containing dissolved drug out of the bag through the macroscopic holes for removal and use.

Abstract: An intravenous drug infusion apparatus for controlling the delivery of a drug includes an in-line mixing vessel with tubular needle-like inlets which produce turbulent mixing of a drug solution contained in the vessel with an aqueous carrier. An admixed solution is discharged from the mixing vessel which provides intravenous infusion of a drug at progressively decreasing concentrations.

Abstract: A cartridge 444, 644, 744 having a drug or other beneficial agent 608 therein and including an adapter 477 is positioned on a receptacle 442, 642 within a parenteral fluid administration set 420. Also disclosed is an adapter 477' for connecting the receptacle 442, 642 to a chamber 606 having a beneficial agent therein. The cartridge and adapter permit a single opening through the injection site at the receptacle and at the chamber at opposite ends of the flow path means while still permitting simultaneous flow both into and out of the chamber and the receptacle.

Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

Abstract: An arrangement in an infusion kit comprising an infusion container with a connected air trap/drop counter for drops, with a discharge piece provided in said trap/counter, and wherein the top of said trap/counter is shaped as a hollow cone or the like, tapering upwards in a working position, said discharge piece extending downwards from the apex of said cone. Said arrangement, furthermore, comprises a drainage hole provided in said discharge piece at its base in the top of said air trap/drop counter.

Abstract: To deliver a controlled dosage of an insoluble material into a living body, the material is provided in measured amounts in vials, and a system is provided for flushing the entire content of insoluble materials from the vial into the body. Insoluble radioactive material, such as glass microspheres incorporating radioactive isotopes, are packaged in a plurality of vials, preferably with different amounts of material. An accurate dosage of radioactivity can be delivered by administering the entire contents of one or more vial(s) according to the sum of radioactivity in selected vials as determined by the initial measurement of radioactivity and by the natural half-life of the isotope.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liquid can be made flow, an outlet for said liquid, and means for receiving and retaining within said drug dissolution space a drug preparation from which a drug is releasable to said liquid during such parenteral delivery, said device characterized in having means for providing the same with one or more durg release cells within which such drug preparation is initially held isolated from the liquid, each of said drug cells having means for emptying its contents of drug preparation into said drug dissolution space after insertion thereof in the drug release device.Such device can be used for sequential emptying of a drug preparation from two or more such drug cells whereby a parenteral liquid dissolves the drug.

Abstract: An intravenous delivery system is disclosed for formulating an intravenously administrable solution in the delivery system. The delivery system comprises means for transferring a fluid and for mixing the fluid with a drug in the delivery system.

Abstract: A nonvented gravity fed exponential mixing and delivery system and apparatus for the administration of a drug in a precalculated manner to give constant therapeutic blood plasma levels in the recipient, (patient), which provides an inexpensive, quick and simple exponential mixing procedure to deliver an infusion containing exponentially decreasing concentrations of a drug, which the exponential mixing of a dilute solution of the drug or isotonic solution which flows by gravity from a conventional IV container, through a coupling means, into a vertically aligned nonvented nondeformable mixing chamber, filled to capacity with a concentrated solution of said drug, said mixing container being provided with a verticle inlet conduit means and a vertical outlet conduit means at opposing ends, each conduit means extending into said mixing container at a height to provide a sufficient height differential to induce exponential mixing of the solutions, to effect an exponentially decreasing concentration of said drug dur

Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a primary container of a medical fluid; (b) a primary drip chamber in fluid communication with the primary container; (c) a primary formulation chamber in fluid communication with the primary drip chamber and housing an agent dispensing device or a beneficial agent; (d) a secondary container of a medical fluid; (e) a secondary drip chamber in fluid communication with the secondary container; (f) a secondary formulation chamber in fluid communication with the secondary drip chamber and housing an agent dispensing device or a beneficial agent; and (g) a common tubing in communication with the primary formulation chamber and the secondary formulation chamber for communicating the system with the recipient.

Abstract: A modular, portable water-jet system for attachment to the faucet of a kitchen or bathroom sink. The system includes a diverter valve assembly that can be screwed to the faucet and which has one outlet having an aerator and another outlet to which is removably attached a control valve assembly to which is removably attached a jet-flow device, such as an oral cleaning nozzle. The diverter valve assembly includes a spool valve slidably mounted in the housing. One end of the spool valve forms a passage from the inlet of the housing leading to the outlet port to the control valves assembly. A modular solution mixing and metering container can be optionally positioned between the diverter valve assembly and the control valve assembly when a liquid medicant or cleaning agent, for example, is desired. A cross-channel at the top of the container opens to the container where water mixes with and pressures the resulting mixture up a vertical pipe back to the cross-channel where it is pressured to the jet-flow device.

Abstract: An intravenous drug administration apparatus is provided which automatically delivers a drug with an exponentially decreasing concentration from a high loading concentration down to a patient maintenance concentration followed by continued infusion at the maintenance concentration rate. The apparatus includes a large container, such as an intravenous solution bag, which holds the low maintenance concentration, and a smaller vessel containing the high loading concentration. The low concentration solution is passed from the large volume container into the lower end of the smaller vessel so as to obtain a continuous mixing action within the vessel, and the mixed and progressively diluted solution is continuously removed from the vessel for delivery and infusion to the patient. The inlet to the vessel may be provided by a short length hypodermic needle and the outlet by a long length hypodermic needle which extends into the upper portion of the vessel.

Abstract: A formulation cell consisting essentially of a hollow fiber surrounded by a beneficial agent is disclosed for use in an intravenous delivery system. An intravenous system is disclosed that uses the formulation cell.

Abstract: A nonvented gravity fed exponential mixing and delivery system and apparatus for the administration of a drug in a precalculated manner to give constant therapeutic blood plasma levels in the recipient, (patient), which provides an inexpensive, quick and simple exponential mixing procedure to deliver an infusion containing exponentially decreasing concentrations of a drug.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A device for orally administering medication by inclusion of a diluent liquid with the medication ingested into the oral cavity. The dosing device in one embodiment has a mouthpiece, a first conduit means for providing a stream of liquid diluent and a second conduit means for positively injecting a liquid medication into the stream of diluent liquid. The dosing device additionally includes as a preferred feature means for supporting a solid medication within the mouthpiece for inclusion within a stream of diluent liquid. In another embodiment, the dosing device comprises a container for solid medicine which is a tubular mouthpiece having a closure cap and a radially flanged base plate for support of the mouthpiece in upright position on a support surface, and a support grid in the tube for the solid medicine.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: An apparatus for connecting a vial into the delivery tube of an intravenous administration set, the set including a container of fluid connected to one end of a delivery tube with the other end of the delivery tube adapted for insertion into the patient. The apparatus includes a penetrating spike penetrating an end of the vial which provides two pathways into the interior of the vial with two sections of the delivery tube connected to the two pathways of the penetrating spike. The apparatus also includes a frame for maintaining the two sections of the delivery tube adjacent to each other and clamp for releasably closing the adjacent sections of the delivery tube to temporarily prevent flow of fluid through the penetrating spike.

Abstract: A medication dispensing device for administering medicine to patients unable to swallow includes a flexible chamber in which solid medicinals, such as tablets, can be pulverized and dissolved or placed in suspension in a liquid medium which thereafter can be administered to the patient from the chamber through an elongate feeding tube through the mouth or nose.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intravenous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to an agent-receiving recipient. The parenteral system comprises an electrotransport apparatus that admits an agent at an electrically controlled rate into medical fluid that flows through the parenteral system over delivery time.

Abstract: Valved adaptors are disclosed permitting the introduction of a drug-containing vial in the delivery tube of an I.V. administration set. The adaptors have a three position operation characterized by a bypass mode, a dilution mode, and a delivery mode, the adaptors being manually changed from mode to mode. The disclosed adaptors include gravity operated valves, reciprocating spool valves, and rotating spool valves, each including a spike to penetrate the stopper of a vial and a vent to permit air to escape the vial as liquid is introduced to dilute the vial contents.

Abstract: A device for releasing active ingredient into a liquid flow passing through a system for parenteral application of the ingredient comprises a receptacle composed of two half shells. The receptacle is subdivided by a ribbed aluminium foil into two chambers and has an inlet at its upper end and an outlet at its lower end. The two chambers have vent means at their upper ends. One of the chambers contains two overflows a first one of which empties into the outlet while the second one empties into the other chamber. In the latter chamber there is present a further overflow which also empties into the outlet, as well as a plate-shaped carrier charged with the active ingredient to be released. The liquid flows from the inlet via the first chamber and the second overflow therein into the other chamber and from there upwardly past a carrier charged with active ingredient, and onward via a third overflow in the other chamber into the outlet.

Abstract: A formulation dispenser is disclosed for use in a parenteral delivery system. The dispenser comprises an inlet for admitting fluid into the dispenser and an outlet for letting fluid leave the dispenser. A beneficial agent is housed in a formulation chamber in the dispenser and a membrane permeable to fluid and agent defines one boundary of the formulation chamber. A piston is slideably disposed in the dispenser for governing the flow of fluid through the dispenser, or for permitting fluid to contact the membrane and enter the formulation chamber for forming a solution containing agent that flows through the outlet into the parenteral system.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.

Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a primary container of a medical fluid; (b) a primary drip chamber in fluid communication with the primary container; (c) a primary formulation chamber in fluid communication with the primary drip chamber and housing an agent dispensing device or a beneficial agent; (d) a secondary container of a medical fluid; (e) a secondary drip chamber in fluid communication with the secondary container; (f) a secondary formulation chamber in fluid communication with the secondary drip chamber and housing an agent dispensing device or a beneficial agent; and (g) a common tubing in communication with the primary formulation chamber and the secondary formulation chamber for communicating the system with the recipient.

Abstract: A formulation cell consisting essentially of a hollow fiber surrounded by a beneficial agent is disclosed for use in an intravenous delivery system. An intravenous system is disclosed that uses the formulation cell.

Abstract: A parenteral delivery system is disclosed for delivering a beneficial agent to an agent recipient. The delivery system comprises a reservoir, a drip chamber and a flexible container that collapses as agent formulation leaves the system.

Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.

Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for delivering a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.

Abstract: A parenteral delivery system is disclosed for administering a beneficial agent to a recipient. The system comprises (a) a container of a medical fluid; (b) a primary tubing in communication with the container; (c) a parallel tubing connected to the primary tubing having a formulation chamber connected thereto, the formulation chamber housing a beneficial agent, or a device for delivering a beneficial agent; and (d) a common tubing connected to the primary tubing and the parallel tubing for administering the fluid and the agent to a recipient.