Abstract: Various aspects of the present invention provide for packages with an outer shell; a first chamber defined at least partially by the outer shell; a second chamber defined at least partially by the outer shell; a fluid-tight rupturable seal separating the first and second chambers; and, a sealed outlet port in communication with the first chamber. With force being applied to the second chamber, the rupturable seal ruptures more readily than the outer shell.

Abstract: A container supplies a medicinal formulation that includes a hydrophilic polymer and an active agent capable of bonding to the polymer. The container includes a first compartment for storing the polymer and a second compartment fluidly isolated from the first compartment for storing the active agent. A frangible barrier is shared between the compartments. A fluidic outlet is disposed on the container to dispense the medicinal formulation. Dispensing of the medicinal formulation includes rupturing the frangible barrier, mixing the polymer and active agent together to form the medicinal formulation, and administering the medicinal formulation provided from the fluidic outlet to a patient. The polymer can be PEG, while the active agent can be magnesium.

Abstract: A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.

Abstract: A hollow inner plunger for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a proximal end and a distal end. A sealing plug and rupturable membrane are disposed at the distal end of the body, and the sealing plug and rupturable membrane are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow inner plunger as described above, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow inner plunger, and the hollow inner plunger is slidably disposed within the syringe barrel. The two components are initially separated by the rupturable membrane.

Abstract: The present invention provides devices and methods for mixing a formulation containing two or more constituents, such as a drug product and a diluent. The devices have a chamber for securing a container of the drug product. Various embodiments are presented. In one embodiment the device has two or more sides connected by a hinge, the two or more sides defining the chamber between them, and a handle for grasping and manipulating the device. In another embodiment the device has a housing with two or more side bars defining the chamber, the container being visible from outside the housing between the side bars and having a stopping element at the distal end, and a handle having two arms for grasping.

Abstract: In an apparatus for storing and administering active substances, at least one transfer mechanism is provided, and a first reservoir that contains an active substance in dissolved form is also provided, the active substance being administered by way of the transfer mechanism. A second reservoir having the active substance in solid form is additionally provided in the apparatus.

Abstract: An automatic mixing and injecting apparatus comprises a syringe assembly (400) within a housing (100). The syringe assembly (400) has a chamber (425) for holding a liquid, which can be a liquid medicine or a solvent. A second chamber (460) may hold a dry medicine. The second chamber (460) is releasably sealed with respect to the first chamber (425). A spring-operated plunger (300) forces liquid from the first chamber (425) and causes the releasable seal (430) to disengage when the needle (540) has entered the recipient. At this time, the liquid flows through the second chamber (460) and dissolves any dry medicine in that chamber (460). A releasable coupling (340) disengages the plunger (300) from the driver spring (500) and allows the plunger (300), syringe assembly (400), and needle (540) to retract under the urging of a return spring (505).

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.

Abstract: A device that delivers a powdery medicine for a nasal cavity includes positioning guides that cause a capsule to slide as far as a predetermined position and are provided on the side of cutters to make holes on both ends of the capsule provided between the connection port on the side of a nozzle that sprays the powdery medicine into the nasal cavity. The device further includes a connection port on the side of a pump that supplies spray air to the nozzle in order to make the size of the holes made on both ends of the capsule constant, wherein a distance between the connection ports is made shorter than a distance between blade tips of the cutters.

Abstract: Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

Abstract: A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

Abstract: The present invention relates to a multi-chamber medical bag, which is capable of obtaining a positive mixture of medicines, prior to the discharge thereof. A weak seal 24 is provided for dividing the space inside the medical bag 10 into the left-handed and right-handed partitions 26-1 and 26-2. The weak seal 24 has a first portion 24-1 extending between the partitions 26-1 and 26-2 and a bifurcated adjacent to and faced with an outlet port 12. Additional strong seals 30-1 and 30-2 are arranged on both sides of the second portion 24-2 and extend at right angle to the first portion 241 toward the strong seal 14 at the outer periphery of the medical bag. When the partition 26-1 or 26-2 is pressed, the resultant inflated deformation of the medical bag is mainly directed to the first portion 24-1 due to the existence of the additional strong seals 30-1 and 30-2, which allows the last portion to be separated, resulting in a mixing of the medicines in the partitions 26-1 and 26-2.

Abstract: This device comprises a tube (22) containing several substantially parallel channels extending along the entire length of tube of which one end, referred to as distal, is connected with a connection element to the patient, thereby forming a mixing chamber for the various liquids, and of which the other end, referred to as proximal, is connected to a housing (3) provided with connection means (9) for several containers each containing a liquid, wherein the housing has liquid delivery lines (7), wherein each delivery line (7) is intended to be connected to a container and to a channel of the tube (22) respectively. At least one delivery line (7) of the housing is provided with a check valve (12) intended to prevent the passage of liquid from the channel of the corresponding tube into the corresponding container.

Abstract: A syringe device having a syringe barrel and a syringe piston having a container housing. At least a portion of the container housing is insertable within an internal chamber of the syringe barrel. A fluid passageway extends from the container housing through a piston stem. A method of protecting a syringe handler including providing the components of a syringe device and encasing the components in a protective film. The protective film is loose to allow manipulation of the syringe components relative to one another without opening or puncturing the film. Protective syringe device packaging that includes a laminate film of material sealed to encase the components of a syringe device containing a potentially harmful agent.

Abstract: This invention finds application in the field of the devices and methods for physical or chemical mixing of products and particularly relates to a cartridge for storage and sterile delivery of a two-phase compound. The cartridge comprises a first tubular member (2) which defines a first chamber (3) for storage of a solid phase, having a bottom wall (6) with an opening (7) for the passage of the compound, a second tubular member (9) which defines a second hermetically sealed chamber (12) for storage of a liquid phase, and a piston which sealably slides within the first tubular member (2), means (8) for occluding said opening (7) which comprise at least one rupturable membrane (15) associated to the bottom wall (6).

Abstract: Certain exemplary embodiments comprise can comprise an auto-injector, which can comprise: a vial configured to store and/or contain an injectable medicament, the vial defining a vial longitudinal axis, and a housing comprising the vial. In various embodiments, the injectable medicament can be a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.

Abstract: A liquid oral medication dispensing system made up of an ampule configured to hold a pre-measured quantity of the selected medication and to dispense that quantity of oral medication through an opening in the ampule formed by a puncturing device. This dispensing system provides a system for storing and delivering oral medications that can be utilized in a broad variety of circumstances by individuals with little or no medical training and provides safe, effective use of the medication.

Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Abstract: Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

Abstract: A delivery device for a bone cement precursor, composites thereof, and support members is provided herein.

Abstract: A storage and dispensing cap for a liquid receptacle having a cap body storage chamber for use with a receptacle such as a bottle, pouch or intravenous bag that is used to store a liquid for use with a syringe that is inserted into the receptacle for drawing the liquid contents into the syringe. A liquid, powder or capsule in the cap body chamber is mixed into the liquid receptacle for use with the syringe. A sleeve penetrator is mounted inside said cap body chamber and is sized in length to permit rupture of the bottom floor of said cap body chamber when manually depressed for dispensing whatever material is placed inside said cap body chamber and sleeve penetrator into said syringe bottle. An open passage from the cap body to the inside of the receptacle is provided once the storage chamber is ruptured by manually depressing the penetrator to allow the syringe needle end to be inserted into the liquid receptacle.

Abstract: A sample substrate configured for samples of biological material is provided. The sample substrate has a dual chambered sample well separated by a wall that may be punctured or otherwise breached to allow mixing of material contained in the two initially separate chambers. The chambers are connected by channels to fluid reservoirs, wherein the channels can be staked to prevent further fluid flow into and out of the chambers. Methods of loading a sample substrate are also provided.

Abstract: A medical device, such as a vascular access device, is disclosed for providing access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.

Abstract: A liquid mixing infusor includes a main body defining an internal chamber and has an upstream port, a downstream port and a confluent port. Each port is fluidly couplable with the internal chamber. A valve may be mounted within the internal chamber of the main body and is adapted for rotational movement between a blocking position interrupting fluid flow between the confluent port and one of the upstream port and the downstream port and between the upstream port and the downstream port, and a flow position permitting fluid flow between the upstream port and the downstream port. A manually manipulative member is mounted relative to the main body and operatively connected to the valve. The manipulative member is movable to cause corresponding movement of the valve between the blocking position and the flow position.

Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebulizer, as well as an active substance concentrate in which the active-substance is present as a solution or suspension for storage purposes.

Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance concentrate in which the active substance is present as a solution or suspension for storage purposes.

Abstract: The invention relates to a syringe-type device for freshly preparing a solution, suspension or dispersion, for example injectable formulations, preferably according to a method for reconstitution in a vacuum. The device is shown in FIG. 1. The invention also relates to a method for packing the fresh preparation of the solution, suspension or dispersion in a cylindrical reservoir that can be used in a single or multi-dose syringe provided for the same. This is a method for packing the preparation inside the cylindrical reservoir, which is closed on one side by an injection plunger whose movement in the reservoir is limited. This method is characterised in that the elements to be packed are introduced into the reservoir from the injection plunger side before the reservoir is closed by said plunger. Said reservoir is a tube or ampule which is closed on the other side in advance.

Abstract: A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.

Abstract: A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannula having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port formed thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communication with the vent port through a vent lumen.

Abstract: The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also useful for alleviating or preventing ischemic tissue damage resulting from ischemia associated with cerebral vasoconstriction which follows aneurysmal subarachnoid hemorrhage, with embolic stroke, with coronary artery obstruction, and with other conditions. These compositions, methods, apparatus, and kits generally relate to adventitial (i.e., extra-luminal) administration of a nitric oxide donor compound to a blood vessel in a mammal.

Abstract: A mixing/charging port for medical treatment capable of reliably absorbing air bubbles. The mixing/charging port for medical treatment includes a disc-like valve having an insertion hole at the center, a seating for supporting the lower part of the periphery of the valve with the center of the rear surface side of the valve not supported, and a cover for restraining the valve by covering at least the upper part of the periphery of the valve with the center on the front side surface of the valve left uncovered, wherein a fitting hole defined by an inner periphery of the cover works as an anchor for anchoring an insertion body to the mixing/charging port by fitting the insertion body to the fitting hole when the insertion body is inserted into the insertion hole; and the tip of the depressed part of the valve is brought into contact against the inner bottom surface of the seating when the valve is depressed by the insertion member.

Abstract: A transfer device and method for deploying one or more pharmaceutical components between a medicine vial and a syringe.

Abstract: A device for delivering a substance into the skin of a patient includes a housing and a plurality of microneedles for penetrating the skin. The housing includes a bottom wall with a plurality of apertures for supplying the substance to the microneedles. The housing also includes a flexible top cover member enclosing a bladder containing the substance to be delivered. The bottom wall of the housing has at least one cannula facing the bladder. Pressing on the top cover member causes the cannula to puncture the bladder and deliver the substance to the microneedles for delivery to the patient. In one embodiment, the cannula is surrounded by a flexible member to prevent piercing of the bladder until sufficient pressure is applied to the cover member to depress the flexible member.

Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A dual chamber syringe in which a dual function piston divides the syringe into two compartments containing powder or fluid in one compartment and fluid in the other. For mixture of the two substances, a passage is opened between the two compartments before or during retraction of the piston to force the substances to be mixed in the front compartment. During forward movement of the piston, the passage between the two compartments is closed to force the mixture of substances through the discharge opening of the syringe.

Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

Abstract: The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance concentrate in which the active substance is present as a solution or suspension for storage purposes.

Abstract: A syringe system requires a decreased vertical travel for sealing during a lyophilization process and therefore provides for increased utilization of space in a lyophilization chamber. The syringe system is provided with a sterility maintenance sleeve including a stopper affixed thereto for sealingly engaging the syringe barrel to define a drug chamber. The sterility maintenance sleeve is provided with a venting passage to permit egress of vapor from the drug chamber during lyophilization. A plug cap cooperating with the sterility maintenance sleeve includes an occluding tip which is adapted to occupy the venting passage and seal the drug chamber after lyophilization. The plug cap is provided with a support structure in the form of flexible fins for supporting the plug cap in a venting position in which the occluding tip is removed from the venting passage to permit egress of drug solution vapor from the drug chamber during lyophilization.

Abstract: Multi-sectioned fluid delivery devices with sensor membranes for use in detection of target molecules in gas or liquid samples are provided.

Abstract: A hermetically sealed container and a medicament bearing insert assembly therefor are disclosed. The medicament bearing insert assembly is protected by a severable overcap. A pocket within the insert assembly is provided with a pierceable membrane. Rupture of the membrane by a built-in plunger causes the medicament to drop out of the pocket and into the container where it is mixed with the container contents.

Abstract: Containers and methods for storing medical solutions are provided. More specifically, containers and methods for storing components that are to be admixed together to create a final solution, one of the components comprising a lipid. In an embodiment, a container including an interior defining at least two chambers. The first chamber includes a lipid containing liquid. The second chamber includes a liquid that does not include a lipid. The first and second chambers are separated by an openable seal.

Abstract: Robotic manipulation of three-part plastic preparation assemblies automatically produces IV solutions which conform to a input specifications of a pharmacist located on site or remotely, including preparation telerobotically. The transparent plastic bag assemblies are stored in a magazine, and are extracted automatically one by one for preparation of individual prescriptions. A supply bag is prefilled with U.S.P. water and is connected through a valve to a mixing bag. Unit dose holders with medicaments and pH adjusting chemistries are dispensed into the mixing bag through an inlet where they are broken open by manipulation, and water is introduced. The bag contents are mixed by rotation of a magnetic mixing bar. The mixing bag is connected by a second valve through a filter to an administration bag. Negative pressure is applied to the administration bag to draw the solution through the filter. The administration bag is then heat sealed and severed from the filter for delivery to the patient.

Abstract: A mixing adaptor enables a material to be transferred from a first delivery means to a second delivery means and enables another material to be transferred from the second syringe to the first delivery means. The adaptor has (i) a hollow main body having a first end, a second end, an interior surface and an exterior surface; and (ii) a septum positioned within the interior surface of the main body. A first channel is defined by a first portion of the interior surface of the main body and by a first side of the septum. The first channel has a primary opening at the first end of the main body and a secondary opening at the second end of the main body. A second channel is defined by a second portion of the interior surface of the main body and by a second side of the septum. The second channel has a primary opening at the second end of the main body and a secondary opening at the first end of the main body.

Abstract: The invention relates to a piercing pin (10) for perfusion purposes to pierce the resilient capsule of a bottle and allow liquid to flow from the bottle (44) to a perfusion system. The piercing pin (10) for perfusion purposes is constituted by a pin body (30) having a longitudinal projection (36) including at least one internal duct (37a, 37b), and piercing means (20) including an internal duct (25) extending said internal duct (37a, 37b) of the longitudinal projection (36), said piercing means (20) are removable and are connected to said longitudinal projection (36) by temporary fastening means (28, 38) for transmitting piercing force to said longitudinal projection (36) and for coming apart from said longitudinal projection (36) when the pin is withdrawn from the bottle. The piercing pin can thus be used once only.

Abstract: A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.

Abstract: An apparatus for altering characteristics of a fluid. The apparatus includes a first perimeter wall defining an internal chamber therein. The first perimeter wall defines a first opening and a second opening therethrough. The first opening is constructed to be fluidly connected to a fluid source. The internal chamber defined in said first perimeter wall is constructed to contain a beneficial agent therein. A beneficial agent is disposed in the internal chamber defined in the first perimeter wall, the beneficial agent being dispersible in a fluid flowing from the first opening to the second opening through the internal chamber defined in the first perimeter wall.

Abstract: A containment and intravenous delivery bag device for supplying a patient with mixed chemical component nutrients includes a first pouch and a second pouch that are separated by a tube passageway. A frangible valve is fitted within the tube. When the frangible valve is broken a first liquid within the first pouch enters the second pouch and mixes with a second liquid within the second pouch. The mixed liquid may then be delivered to the patient.

Abstract: Sterile solutions containing pharmaceuticals suitable for use in low and micro-gravity environments are prepared with unit dose pharmaceutical dispensers having a pre-measured quantity of medicament. A compressed air reservoir may be activated to rupture the dispenser and positively expel the unit dose into solution. This can be accomplished by inverting a bag containing the pharmaceutical or by operation of a piston which pushes all the pharmaceutical from the dispenser. A robot either places the pharmaceutical dispensers inside a mixing chamber or connects the dispensers to the mixing chamber, which comprises a flexible bag expandable to receive sterile water and pharmaceuticals. The mixing chamber may collapse under cabin pressure to drive prepared solutions from the chamber through a sterilization filter into an intravenous bag or dispensing unit.