Abstract: A flexible container is provided for the storage and mixing together of diluents and medicaments. The container incorporates multiple compartments, separated by frangible seals, in which the diluents and medicaments are stored. The seals are ruptured by manipulation of the container to thereby mix the contents together for delivery through a standard IV arrangement to a patient.

Abstract: A dental capsule for mixing a cement powder with an activating liquid having a frangible seal. The frangible seal is placed between a nozzle and the body portion of a capsule preventing unmixed cement from entering the nozzle. The nozzle has a circumferential groove facilitating positioning thereof. A vent formed in the body of the capsule prevents premature rupturing of the frangible seal upon insertion of the plug. A second and third embodiment use a two-part plug for dispensing activating liquid to the cement powder contained within the body of the capsule.

Abstract: A controlled action mixing vial (2) includes an elongate mixing container (14) having a movable piston (18) and fluid pressure rupturable seal (20). One pharmaceutical (58) is housed within the mixing container between the seal and the piston. A supplemental container (28) is coaxially translatably mounted to the mixing container and contains a second pharmaceutical (62) between the mixing and supplemental containers. Collapsing the mixing and supplemental containers causes the rupturable seal to open permitting the second pharmaceutical to be driven into the mixing container to drive the piston along the mixing container. The mixing and supplemental chambers are threadably coupled (10, 32) so the mixing is accomplished in a controlled, slow manner.

Abstract: An aerosol dispensing device provides increased shelf life for aerosols containing unstable ingredients or reactive compounds. The device includes a container and a valve which, upon actuation of an actuator, has a portion which is depressed downwardly into the container. In some forms of the invention, the downward depression is exerted directly against a glass ampule containing a composition to be isolated from the container contents or valve mechanism. Such depression causes the ampule to break releasing its components where they may mix within the container. In another form of the invention, depression of the actuator causes a relatively heavy ball to be released into the container generally where it may contact and break a frangible liquid containing ampule within the container. The device of the invention provides physical separation of components within the ampule from components generally within the container until the first depression of the acuator.

Abstract: An assembly of containers is provided for efficient and controlled storage of a reagent and subsequent mixing of the reagent with a reagent diluent. The assembly includes a reagent diluent container and a sealed reagent vial. An adapter assembly includes a coupler having one end mountable to the reagent diluent container and having the opposed end defining a hollow plunger. A retainer ring has one end mountable to the coupler and the opposed end mountable to the reagent vial. The reagent vial is engageable with the coupler in a first position and is advanceable into a second position relative to the adapter assembly such that the hollow plunger thereof displaces the seal of the reagent vial permitting the reagent in the reagent vial to flow through the hollow plunger to mix with a buffer or diluent in the reagent diluent container.

Abstract: A vial (2) has first and second chambers (56, 54) initially separated by a rupturable barrier (20). The first chamber is a variable volume chamber defined by a cylinder (18), the rupturable barrier at the second end (19) of the cylinder and a piston (14). The second chamber is created by a telescoping container (22) mounted to a second end of the cylinder. The chambers are telescopically collapsed causing fluid pressure in the second chamber to rupture the barrier so the components mix in the first chamber. The piston is driven through the cylinder from pre-mix to post-mix positions by the liquid from the second chamber. This dislodges a safety shield at the first end of the cylinder to expose the piston. The mixed contents of the first, variable volume chamber are removed by inserting a needle cannula through the now exposed piston; aspiration of the mixed contents take place without the introduction of air into the first chamber since the piston moves back down the cylinder as the contents are removed.

Abstract: A sterile fluid mixing reservoir for storing premeasured quantities of fluids for subsequent combination is disclosed. The reservoir has a flexible outer bag which fully encloses one or more inner containers. The inner containers have self-opening mechanisms thereon which are manipulable through the outer bag. The bottles can be manufactured from a flexible material which facilitates intermixing of the fluids contained within the bag and inner containers.

Abstract: The present invention comprehends the provision of a fluid tight holding chamber which accumulates solution from the vial that aspirates during mixing or drawing fluid from the vial or is pressured out of the syringe upon extraction of the cannula from the vial. The holding chamber is defined in conjunction with the vial septum by a shield cap that surrounds and seals to the neck of the vial. The shield cap defines a guide for the cannula of the syringe and directs the cannula through a sealing member, the holding chamber, the septum and into the vial. One aspect of the invention provides a sleeve portion on the shield cap that receives and retains the syringe barrel. An arm is provided on the sleeve portion and has a notch that holds the syringe barrel in a predetermined position during shipment and storage of the assembly.

Abstract: A capsule for a tooth-restoring material includes a cylinder containing therein the predetermined amount of a powder component of the tooth-restoring material and fitted at its rear end with an extruding plunger; a breakable package held in front of an extreme end opening in the cylinder, the package containing therein an amount of a liquid component of the tooth-restoring material and having its cylinder-facing side formed of a weak material; and a member for holding the package having a nozzle at its outermost end; wherein at a position of the plunger corresponding to the extreme end opening in the cylinder is provided a member capable of breaking through the package of a size small enough not to close up the opening and the nozzle, when the plunger moves to and reaches the package-holding member.

Abstract: The container is intended for mixing infusion solutions with ingredients and for administering the mixture. It consists of a bag which forms the mixing space, is made of flexible material and is provided on each of the two narrow sides with a tubular connecting part, the connecting parts being equipped with connectors.

Abstract: A unit dose medicament storing and mixing system is described having a dual compartmented and collapsible container for use in an intravenous administration system. One of the compartments contains unit dose measurements of sterile medicament (in powder or liquid form), the second compartment to contain sterile intravenous fluid to be used as a diluent. The two compartments are separated by a closure which is separable and resealable. An external clamping device is used to lock the resealable closure and keep the compartments separate. Prior to the infusion of the activated medicament to the patient, the drug is prepared by removing the external clamp and separating the resealable membrane device, thereby providing fluid communication between chambers and effecting intermixing of the contents thereof. The membrane can then optionally be resealed in order to separate the medicament to be delivered from any residual air left in the container.

Abstract: The cap reservoir and dropper assembly for bottles includes a reservoir (1) fitted with a collar 913) adapted for resting on the mouth of a bottle (4), a delivery piston (2) the lower part of which is shaped like a flute mouthpiece (24) and the upper part of which is shaped like a collar (22). The assembly further includes a cap (3) the lower part of which is in the form of a removable strip (33). The delivery piston is equipped in its upper part with a dropper (23). The cap may be equipped with a feature which cooperates with the delivery piston collar to push the delivery piston downwards.

Abstract: The invention relates to an automatic two-chamber injector for mixing and injecting a medical solution. The injector comprises a barrel (11) having a first end with a receiving portion (15) for an injection needle (17), said portion being sealed prior to use, and a second end with a displaceable plunger (27). The barrel (11) comprises two chambers (29, 30) separated by a migrationproof membrane (28), said membrane (28) being adapted to rupture when the plunger (27) is displaced towards the first end of the barrel (11).The invention also related to a method for mixing and injecting a solution by means of an automatic two-chamber injector and to a cartridge for a two-chamber injector.

Abstract: Automatic injection device, as well as ampoule or cartridge for the same. In order to obtain a high speed discharge of an ampoule-hypodermic needle, as well as to ensure an operationally reliable, low weight, robust small apparatus or ampoule at long storability, sterility and re-usability of components for a plurality of injection substances, the needle body (30) of the cannulahypodermic needle (3) is constructed over part of its extension as a needle bearing (31) guided in sliding fit on the inner wall (21) of the cartridge (2). Particularly with a view to administering separate injection substances, it is provided for a cartridge or ampoule with needle and lifting element, that within the ampoule there is arranged a receptacle forming a gas volume, which receptacle can be destroyed easily by initiating the lifting movement and which is resistant to the injection fluid surrounding it.

Abstract: A vessel for safe handling of substances and having a first connection member through which the interior of the vessel is accessible by a device, e.g., an injection syringe, for removing or adding material thereto. At least a part of the vessel is expandable and contractable. The vessel is further provided with a second connection member, which is interconnected or interconnectable with the first connection inside the vessel. The second connection member is connectable to a further vessel outside the vessel, so that substance can be transferred directly from the injection syringe to said further vessel via the first and second connection members.

Abstract: A branch tube comprising a main tube defining a continuous flow path and one or two branches connected to the main tube has a closure member connected to one end of the main tube to block the flow path thereof. The closure member is integrally molded with the main tube so that a continuous smooth flow path extends through the main tube up to the closure member and the closure member is breakable from the main tube to open the flow path. A tubular sleeve is connected to the main tube so as to surround the closure member.

Abstract: A medicament container/dispenser assembly includes a substantially non-collapsible main body defining a chamber for containing the medicament in liquid form, the main body having an upper portion and a lower portion; an opening formed in the upper portion; a liquid impervious, gas permeable membrane secured to the upper portion of the main body in sealing relation to the opening; a rupturable exit port formed in the lower portion of the main body. The assembly may also include a second opening formed in the upper portion of the main body in spaced relation to the first-mentioned opening and an elastomeric, puncturable, sealing material secured to the upper portion of the main body in sealing relation to the second opening. In a further embodiment, a conduit may be positioned adjacent the membrane at the upper section of the main body, and may contain a blower for supplying forced air to the membrane through the conduit.

Abstract: A casing includes a body having an opening closed by a film which can be torn off in one piece; the body is formed into two adjacent compartments one of which receives a basic product and the other having a dish receiving area and a dish received therein for an additional product; the dish is provided with a perforator for perforating a cover provided over the compartment section housing the dish; the portion of the compartment for the dish remote from the film and cover is shaped to be deformable by manipulation to allow the cover to be perforated and the additional product to be ejected from the dish into the compartment.

Abstract: A portable controlled release osmotic infusion device, which can be activated on demand by the user, comprising a rigid housing containing:a. a fluid-imbibing assembly, comprising a solvent-containing chamber and a solute-containing chamber; the two chambers separated by a rigid semipermeable membrane covered by a thin taut foil seal,b. a drug-containing chamber separated from the fluid-imbibing assembly by a leakproof impermeable elastic diaphragm, which expands into the drug-containing chamber in use and drives the drug through a dispersing orifice at a steady rate, andc. an activating device which ruptures the foil seal described in (a) above and initiates the osmotic action of the device.The osmotic device is filled with drug in solution or suspended form during manufacture and can be stored without deterioration of the contents for prolonged periods of time.

Abstract: A method of preparing a self-curing two-component cement, which is particularly useful for the preparation of bone cement used in orthopedics, from a powder component and a liquid component. The method includes providing the powder component in a first at least partially evacuated inflexible container, providing the liquid component in a second inflexible container, and adding the liquid component to the evacuated powder component, such that the liquid floods the evacuated interspaces between the powder particles. An apparatus for carrying out this process is a syringe with a slidable piston, the syringe being sealed at its dispensing end by a removable plug. Preferably, the syringe is fitted with an axially collapsible spiral mixing device, one end of which is an elongated shaft which extends through the removable plug at the dispensing end. The elongated shaft can be rotated to homogenize the contents of the syringe, but during dispensing the mixing device collapses as the piston advances.

Abstract: The invention relates to an instrument for bone marrow puncture comprising a sampling needle (10) fused to a piston which can be displaced within a piston barrel (4), a mechanism (6) for releasing the piston from a first position, at which the needle is entirely withdrawn within the interior of the anterior part of the said piston barrel, to a second position at which the extremity of the needle is projected to the outside. The stroke of the piston is sufficient for the needle to pierce the bone and reach the region of the bone marrow where sampling is to be carried out, when the anterior part (32) of the instrument is placed and maintained at the height of the appropriate bone. The posterior part of the piston barrel defines a closed chamber (16) for the collection of the marrow sample aspirated into this chamber under the effect of the negative pressure generated by the displacement of the piston from the first to the second position.

Abstract: A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liquid can be made flow, an outlet for said liquid, and means for receiving and retaining within said drug dissolution space a drug preparation from which a drug is releasable to said liquid during such parenteral delivery, said device characterized in having means for providing the same with one or more durg release cells within which such drug preparation is initially held isolated from the liquid, each of said drug cells having means for emptying its contents of drug preparation into said drug dissolution space after insertion thereof in the drug release device.Such device can be used for sequential emptying of a drug preparation from two or more such drug cells whereby a parenteral liquid dissolves the drug.

Abstract: To separate drugs within a chamber (66) formed beneath a dome-like housing (24) from another biomedically active substance, the chamber (66) is subdivided into two chamber portions (166, 266) by enclosing, within said chamber, a plastic bag (101) or by stretching a membrane (102) thereacross. The plastic bag, or the membrane, respectively, is ruptured upon depression of a terminal element (34) located at the apex of the dome of the housing. The subdivision of the chamber into two chamber portions prevents intermixing of the biologically active substances during storage. One of the chamber portions may retain liquids which are suitable in the article, and preferably are separated from another one of the liquids, such as a surfactant, and thus permits a wide choice, of, respectively, biologically active and other substances. Unintended leakage of the substances through a microporous membrane (76) closing off the housing is prevented by applying a cover strip across the membrane.

Abstract: A mixing syringe having an inner cylindrical barrel open at one end, and closed at its other end by a thin, tough, membrane bonded thereto. The barrel may contain a first liquid. A plunger inserted in the barrel has a sliding, sealing head which applies pressure to the liquid to rupture the membrane when the plunger is advanced. The barrel is slidably inserted in an open end of an outer barrel in sealing relationship therewith, and has a tip on the other end of the outer barrel. The outer barrel contains a liquid or other material to mix with the first liquid when the membrane is ruptured. The mixture is discharged from the outer barrel via the tip when the inner barrel is advanced axially in the outer barrel.

Abstract: A fluid administration apparatus which comprises a fluid receptacle and a fluid administration conduit assembly having a hollow fluid administration tube, a handle and a hollow spike unit extending axially outwardly from said handle said handle and said fluid tube being adapted to be positioned exterior to said receptacle and said spike being adapted to be positioned within said receptacle, said spike including a shank and a tip and said receptacle comprising two fluid chamber separated by a pierceable membrane.

Abstract: A disposable finger applicator adapted to facilitate the application of a two-component therapeutic agent to gum tissues for treating periodontal disease. The applicator includes a collapsible thimble which when in use fits on the index finger of the user, the thimble being bonded to the rear wall of a small envelope formed of opaque, non-stretchable film material containing a charge of hydrogen peroxide in an aqueous solution. Marginally secured to the front wall of the envelope and otherwise spaced therefrom to define an internal cavity is an outer layer of porous, sponge-like material, the cavity being filled with dry sodium bicarbonate powder. The front wall of the envelope is provided with a weakened zone, such that when the finger applicator is pressed by the user against gum tissue, the hydrogen peroxide solution trapped in the envelope then ruptures the weakened zone, thereby causing the solution to leak into the cavity and to intermingle with the sodium bicarbonate powder.

Abstract: A combination mixing and discharge capsule for storing separate ingredients which are to be mixed together prior to use and including a container body for one ingredient closed at one end by a slidable piston and the opposite end being displaceably received in a cup-shaped cap which forms a second compartment with a perforated wall of the container body opposite the end containing the piston for receiving a frangible pillow containing a liquid second ingredient to be mixed with the ingredient in the body. The cap has a discharge nozzle extending axially therefrom and when the cap is displaced farther onto the body the innermost wall of the pillow is burst to cause the discharge of the liquid ingredient through the perforated wall end into the container body for mixing with the ingredient therein.

Abstract: Dosages of a radionuclide carrier for use in diagnostic nuclear medicine are prepared in separate, aliquot quantities by storing a discrete amount of a lyophilized radionuclide carrier material in tubular containers. The containers are closed to exclude moisture and air. The radionuclide carrier is reconstituted as an aliquot dosage by interposing the container between the needle and barrel of a hypodermic syringe, and drawing a predetermined amount of a reconstituting liquid into the syringe barrel through the needle and through the container. The liquid dissolves the lyophilized carrier to form an aliquot dosage for each patient, only as needed.

Abstract: The present invention comprehends the provision of a fluid tight holding chamber which accumulates solution (1) from the vial that aspirates or is pressured out of the vial upon extraction of the cannula from the vial or (2) is aspirated from the syringe before the cannula is removed from the holding chamber. The holding chamber is defined in the neck of the vial by an insert. The insert may be one piece or two piece and has an inner end sealing the contents of the vial from the holding chamber and an outer end sealing the aspirated medicament in the holding chamber. The insert has a luer seal for sealing against the luer connector on the syringe during the practice of certain procedures.

Abstract: A system for separately storing and sterilely mixing a diluent and a medicament within a dual chambered flexible container for eventual use in an I.V. administration system. Mixing of the contents of the two chambers is accomplished by compressing the sides of the flexible container thus causing a weakened portion in the partition between the two chambers in the flexible container to rupture, thereby providing fluid communication between the chambers and effecting intermixing of the contents thereof.

Abstract: A compartmented and collapsible container system for sterile components which has a separate compartment for each component with a secondary container compartment within a larger container compartment, yet will permit the intermixing of the components upon the selective delamination of a frangible seal which separates the compartments. The compartmented container is specifically constructed for use with two components which are normally incompatible when mixed. The container herein described permits the two incompatible components to be sterilized in a disposable, flexible container. At the time of usage, the two materials can be readily intermixed in the same container and administered therefrom, such as with the usual intravenous administration equipment.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by moving a piston member with a piercing element in the direction of the diluent container to pierce a diaphragm or stopper in the medicament container. In one embodiment, the medicament container is sealed by means of a flange to the diluent container wall and the piercing element will pierce a diaphragm and the container wall with the piercing member also serving as an injection site.

Abstract: A dual compartmented container containing a medicament in one compartment and a diluent in the other with an actuating piercing element operable from outside the container. Mixing of the medicament in one compartment with the diluent in the other is accomplished by moving the piercing element inwardly into the container to pierce a primary diaphragm which seals one of the compartments to outside atmosphere as well as a secondary diaphragm which seals the compartments from each other. The piercing element is constructed and arranged to afford fluid communication between the compartments after it pierces both diaphragms. Intermixing of the contents of the container can thereby be made internally thereof.

Abstract: An improved syringe incorporating a solid powdered medicament and a dissolving fluid in a compact manner utilizes a compartment for the solid material which may be readily packaged commercially and an arrangement whereby fluid and solid components may be mixed and the latter dissolved while maintaining complete hermetically sealed conditions for all components including the injection needle until the latter is ready for injecting into the patient or intravenous device. This is accomplished by a specially constructed tube which surrounds and seals the syringe barrel, injection needle, and medicament and diluent until ready for use. Added features are rigidity, simplicity and economy in manufacture, safety against malfunction and simplicity in operation by customarily trained personnel.

Abstract: A pre-filled chamber having a piston plug at one end and a stopper at the other end. The chamber is filled with a powdered medicament that is to be intermixed with a diluent in a container. Rotatable attachments join the chamber containing the powder with a receptacle on the container. The powdered medicament is expelled from the chamber by the force of a plunger acting on the piston plug. The stopper at the end of the chamber containing the powder serves as a mounting for a piercing tip which breaks a membrane over the neck of the container allowing fluid connection between the chamber and the container and transferral of the powdered medicament from the chamber to the container.

Abstract: A container (34) includes first and second chambers (40, 42) for the storage of two substances (44, 46) such as medical liquids. The chambers are separated by a chamber-communicating assembly (61) which is selectively opened by an operator for mixture of the two substances and delivery to a patient. A leak detection compartment (62) encloses the assembly (61) between the two chambers, including a periperhal channel (76) and ridges (80) on the assembly (61).When seal integrity between the container wall sheets (36, 38) and the assembly (61) is less than complete, the leak detection compartment both prevents liquid in one chamber from entering the other through the leak pathway and also assures detection of the leak during the manufacturing operation.

Abstract: A container adapted for the mixing of a liquid and a solid initially placed in separate compartments. The compartment containing the solid has two access ports so liquid can pass through the compartment carrying the solid with it for better mixing.

Abstract: An amalgam capsule includes two chambers separated by a piston detachably formed as a part of the capsule end cover. One compartment is formed in part by a resilient flange portion of the capsule which is deformable to provide communication of the chambers and to permit a mixing of the contents of the chambers in the larger of the chambers. Delivery of the mixed amalgam is accomplished by removing a cap from one end of the capsule to expose an aperture therein, and connecting the opposite cover end of the capsule to a syringe, the plunger of which detaches the piston from the capsule cover and drives the piston through the mixing chamber to eject the amalgam therefrom.

Abstract: Provided is a process for preparing an aseptic container for separately storing a sterilized powdered component and a sterilized liquid component under clean conditions. The container includes two sealed chambers having a frangible, sterilized connection therebetween, one said chamber containing the liquid component, and the other said chamber including a sealed vial containing a powdered component. The vial has an outer surface that is aseptic throughout its entire surface area, and the frangible connection provides a sterile pathway, when desired, between the interior of the vial and the interior of the liquid-containing chamber.

Abstract: To prepare and apply two-component cement, the components are vacuum-packaged in elongated flexible fluid-tight compartments and those compartments are confined in abutting relation with a seal existing around the abutting portions of the compartments. One of the compartments is gradually collapsed to force its contents to break through the abutting wall portions into the other compartment while the extension of the other compartment is controlled as it receives the one compartment contents so as to enhance the intimacy of contact between the cement components. Then the other compartment is gradually collapsed to force its contents into the one compartment while controlling the extension of the one compartment as it receives the other compartment contents so as to further mix the components. The two compartments are alternately collapsed and controlledly extended until the components therein form a homogeneous cementitious mixture.

Abstract: An injection syringe is disclosed which comprises a cylinder equipped at one end with an attachment flange and at the other end, near to an outlet or discharge opening thereof, with a catheter connection. A piston member is insertable into the cylinder, and a container or receptacle is located between the piston member and the outlet or discharge opening. The container is provided with reference fracture locations and is freely displaceable within the cylinder in the lengthwise direction thereof. This container is filled with one of two liquids. After the ejection of the other liquid located within the cylinder externally of the container the container splits open and releases the injection the liquid contained therein. The injection syringe can be used, for instance, for the injection of a contrast agent followed by flushing with a physiological saline or salt solution, but also can be used in all other fields of application where it is desired to apply in timewise succession two liquids.

Abstract: A syringe assembly comprising a casing for a medicament or the like having a discharge opening at one end, a diaphragm assembly mounted at said end normally sealing said contents, plunger means movable in said casing and operable upon displacement in one direction to effect increase in pressure in said casing to rupture or displace said diaphragm to permit discharge of the contents of said casing.

Abstract: The invention provides a unit package for use in connection with a system for supplying liquid vaccine composition to an apparatus for substantially simultaneously debeaking and vaccinating poultry chicks. The package comprises a compartmentalized container the compartments of which contain(a) a plurality of liquid diluent supply bottles containing sterile diluent for rehydrating dehydrated vaccine,(b) a transfer spike assembly comprising a cover unit sealed with a tear-away cover and containing a transfer spike suitable for providing sterile flow means from a liquid diluent supply bottle to a bottle containing dehydrated vaccine and(c) a drip chamber-tubing-clamp assembly suitable for sterile transfer of liquid vaccine from a liquid supply bottle to the liquid injecting means of an apparatus for substantially simultaneously debeaking and vaccinating poultry chicks.

Abstract: A douche product which comprises a bottle filled with a douching liquid, a reservoir in the bottle containing a liquid to be mixed with the douching liquid and a nozzle attached to the bottle for dispensing the contents of the bottle, the nozzle and the reservoir having cooperating devices so that the reservoir may be opened to permit the contents thereof to drain into the bottle when the nozzle is moved relative to the bottle.

Abstract: A container having a unique two chamber construction provides for the passive mixing of two supply solutions having different specific gravities into a single homogenous solution in a closed environment. The container includes means for a positive test that a single homogenous solution has been achieved. The container is especially useful for storing and mixing two supply solutions which when mixed form a single medical solution which itself is unsuitable for storage over extended time periods.

Abstract: A combination mixing and discharge capsule for storing separate ingredients which are to be mixed together prior to use and including a container body for one ingredient closed at one end by a slidable piston and the opposite end being displaceably received in a cup-shaped cap which forms a second compartment with a perforated wall of the container body opposite the end containing the piston for receiving a frangible pillow containing a liquid second ingredient to be mixed with the ingredient in the body. The cap has a discharge nozzle extending axially therefrom and when the cap is displaced farther onto the body the innermost wall of the pillow is burst to cause the discharge of the liquid ingredient through the perforated wall end into the container body for mixing with the ingredient therein.