Abstract: Methods and sensors for selective fluid sensing are provided. Each sensor includes a resonant inductor-capacitor-resistor (LCR) sensor that is coated with a sensing material. In order to collect data, an impedance spectrum is acquired over a relatively narrow frequency range, such as the resonant frequency range of the LCR circuit. A multivariate signature may be calculated from the acquired spectrum to discern the presence of certain fluids and/or fluid mixtures. The presence of fluids is detected by measuring the changes in dielectric, dimensional, resistance, charge transfer, and other changes in the properties of the materials employed by observing the changes in the resonant electronic properties of the circuit. By using a mathematical procedure, such as principal components analysis (PCA) and others, multiple fluids and mixtures can be detected in the presence of one another, even in a high humidity environment or an environment wherein one or more fluids has a substantially higher concentration (e.g.

Abstract: The invention deals with a method for the assessment of the effect of excipients, pH and combinations thereof on the predicted absorption properties of low solubility compounds, comprising the step of assessing a change in a flux function for a combination of a low solubility compound and an excipient at at least one predefined pH value. The method allows a fast, accurate, and economic evaluation of an excipient being capable of optimizing the absorption of drug molecules, i.e. low solubility compounds. Furthermore, animal experiments can be excluded and use of compounds can be reduced in such evaluation. Thus, screening for future formulation efficacy (pH and excipient effects on solubility and permeability) of drug candidates can be justified, since the method is fast, compound-sparing, cost-effective, and reasonably accurate.

Abstract: Systems and method for curation of mass spectral libraries. In general, the systems and methods provided herein (a) obtain an experimentally derived mass spectrum of a compound of interest; (b) identify a peak in the mass spectrum that represent an experimental m/z value for an ion fragment of the compound of interest; (c) remove from the mass spectrum any peak that does not correspond to the compound of interest; and (d) replace the experimental m/z value for the peak identified in step (b) with a calculated theoretical m/z value for the ion fragment.

Abstract: A portable monitor used to measure landfill gas and landfill well parameters. The portable monitor includes a control unit and a measuring unit that can communication wirelessly with one another. The control unit and/or measuring unit can includes a heating arrangement to increase the temperature of one or more components in the control unit and/or measuring unit in cold environments.

Abstract: The present invention is related to a direct solid sample analytical technology for determining a content and a uniformity thereof in a lyophilized kit of a sulfur-containing chelator with a stable complex capacity for radiotechnetium (Tc-99m) and radiorhenium (Re-186, Re-188). An economical, stable and easily accessible coal standard is used herein as a contrast substance to construct a sulfur calibration curve, followed by obtaining the sulfur content and the uniformity thereof in the solid lyophilized sample by interpolating the foregoing result into the sulfur calibration curve. Then, the weight content percent is converted to get the content and the uniformity of the chelator in the lyophilized kit. The quality control of active pharmaceutical ingredients (API) in the lyophilized kit during key production processes and clinical applications is thus assured.

Abstract: A portable monitor used to measure landfill gas and landfill well parameters. The portable monitor includes a control unit and a measuring unit that can communication wirelessly with one another. The control unit and/or measuring unit can includes a heating arrangement to increase the temperature of one or more components in the control unit and/or measuring unit in cold environments.

Abstract: A method of supporting a diagnosis of an effect of a treatment by using anthracycline anticancer drugs is disclosed. The method provides a new value for judging an effect, a judgment score, which is calculated based on expression levels and activity values of two cyclin dependent kinases (CDKs). The effect of the treatment by using anthracycline anticancer drugs is judged by comparing the judgment score with a predetermined threshold level.

Abstract: Methods are disclosed for automatically analyzing a chromatography/mass spectrometry spectrum characterized by at least a time-related variable, a mass-related variable and an ion-abundance-related variable, comprising the steps of: receiving a portion of the spectrum from a chromatography/mass spectrometry apparatus while the chromatography/mass spectrometry apparatus is concurrently generating another portion of the spectrum; automatically subtracting a baseline from the portion of the spectrum so as to generate a baseline-corrected spectrum portion; automatically determining if at least one spectral peak occurs in the baseline-corrected spectrum portion; and reporting information relating at least to the number of peaks automatically determined in the portion of the chromatography/mass spectrometry spectrum.

Abstract: Systems and methods for the provisioning of price protection contracts which provide price protection against adverse fluctuations in the retail price of a commodity to a consumer are disclosed. While these price protection contracts may pertain to almost any type of commodity, certain embodiments of the present invention may provide systems and method for allowing a consumer to obtain price protection on the purchase of fuel. Specifically, embodiments of the present invention may provide the ability for fleet managers to obtain a price protection contract for the purchase of fuel where the price protection contract specifies at least one lock price, quantity, locale and time period such that the price protection contract may guarantee the right to aggregately purchase the quantity of fuel in the locale at the lock price during the time period.

Abstract: A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.

Abstract: Systems and methods for reducing background noise in a mass spectrum. The method includes the following steps of: (a) obtaining an original mass spectrum; (b) determining a noise mass spectrum corresponding to background noise in the original mass spectrum; and (c) determining a corrected mass spectrum by subtracting the noise mass spectrum from the original mass spectrum. Step (b) of the method may include the steps of: A) effecting a transformation of the original mass spectrum into the frequency domain to obtain an original frequency spectrum; B) identifying at least one dominant frequency in the original frequency spectrum; C) generating a noise frequency spectrum by selectively filtering for said dominant frequencies; and D) determining the noise mass spectrum by effecting a transformation of the noise frequency spectrum into the mass domain.

Abstract: A method for selecting an operative component to combine first and second immiscible phases includes selecting a first operative component and computing the value of the free energy of mixing for it and the first and second immiscible phases. If the computed free energy is greater than zero, the sigma profile of the first candidate is mutated to define a hypothetical sigma profile of a candidate substitute operative component. The free energy of mixing for the substitute and the first and second immiscible phases is computed. The mutation and computation are repeated for a predetermined number of repetitions or until the free energy of the candidate substitute component and the first and second phases is less than zero, whichever first occurs. A material exhibiting a sigma profile corresponding to that of the candidate substitute producing a free energy of solvation less than zero is selected.

Abstract: An analyte testing device is provided for use with a mobile processing device having a camera with a lens, a processor for processing an image captured by the lens. The analyte testing device comprises a casing and a test strip positioner. The test strip positioner positions an analyte containing test strip adjacent to the camera lens to permit the camera to capture an image of the analyte containing test strip. A light source is disposed within the casing. The light source is positioned within the casing to illuminate the analyte containing test strip to facilitate the capture of the image of the test strip. Software is contained within the mobile processing device for performing a quantitative analysis of at least one analyte from the captured image, and providing an output of the results of the quantitative analysis.

Abstract: A method for quantitating a substance to be measured including: storing a database with which a relative calibration curve is registered; measuring an internal standard substance having a known concentration; calculating the peak area or the height of an internal standard substance by preparing a chromatogram on the basis of a mass spectrum of the internal standard substance; gaining a mass spectrum of the substance to be measured by measuring the substance; calculating the peak area or the height of the substance by preparing a chromatogram on the basis of the mass spectrum of the substance to be measured; and of calculating the concentration of the substance on the basis of the relative calibration curve, the peak area or the height of the internal standard substance and the peak area or the height of the substance.

Abstract: Disclosed is an assay result reading apparatus, for reading the result of an assay, comprising: a) first and second control thresholds; b) a data processing means for processing an analyte measurement signal indicative of the presence and/or amount of an analyte; and for processing a control signal indicative of whether the assay has been carried out satisfactorily; to: up until a time t1 after commencement of the assay measurement, to compare the control signal with the first control threshold and determine that the assay has been carried out satisfactorily if the control signal exceeds or is equal to the first control threshold, and if the control signal is less than the first control threshold to continue the assay measurement; and at a time t>t1 to compare the control signal with a second control threshold and provide an assay result if the control signal exceeds or is equal to the second control threshold.

Abstract: The density of a fluid is determined using a vibratory resonant densitometer in an environment. The densitometer includes a tubular sample cavity and other densitometer parts. The method includes measuring a plurality of parameters characterizing the environment. The method further includes adjusting a model of the sample cavity using the measured parameters. The method further includes receiving a sample fluid into the sample cavity. The method further includes vibrating the sample cavity to obtain a vibration signal. The method further includes calculating the density of the sample fluid using the model and the vibration signal.

Abstract: Systems and methods for unmixing spectroscopic data using nonnegative matrix factorization during spectrographic data processing are provided according to various embodiments. In an embodiment, a method of processing spectrographic data may include receiving optical absorbance data associated with a sample and iteratively computing values for component spectra using nonnegative matrix factorization. The values for component spectra may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of a pathlength matrix and a matrix product of a concentration matrix and a component spectra matrix. The method may also include iteratively computing values for pathlength using nonnegative matrix factorization, in which pathlength values may be iteratively computed until optical absorbance data is approximately equal to a Hadamard product of the pathlength matrix and the matrix product of the concentration matrix and the component spectra matrix.

Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.

Abstract: A plurality of Raman spectral datasets of an unknown sample acquired under the same measurement conditions is selected in a plurality of Raman spectral data items having different spectral profiles acquired by setting different measurement conditions in a plurality of unknown mixed samples, a spectrum acquired under the same measurement conditions as those of the Raman spectral dataset of the unknown sample is selected in the spectra of the benchmark molecule to be classified, a PCA loading is calculated from the Raman spectral dataset of the unknown sample, the correlation between the calculated PCA loading and the selected spectrum of the benchmark molecule to be classified is calculated, and the PCA loading having a highest correlation with the spectrum of the benchmark molecule to be classified is determined in the PCA loadings calculated from a plurality of Raman spectral datasets of the unknown sample having different measurement conditions.

Abstract: A system includes an estimating unit to non-destructively estimate a fat content and a water content of a food sample. The system further includes a processing unit operatively coupled to the estimating unit to determine a calorie content based solely on the fat content and the water content of the food sample.

Abstract: The discovery that apolipoprotein B exhibits spectral features in the mid IR spectrum that make it identifiable within blood serum leads to the invented use of a statistical correlation between a concentration of apolipoprotein-B (apoB) in a sample of blood serum and infrared spectral features of the blood serum sample to produce a test for apoB. A method for providing such a test, and tests produced by the method are taught.

Abstract: A method for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of two medicines on the basis of distribution of medicine-effective genes of two medicines; determining a medicine similarity factor (AS1,2) of two medicines on the basis of similarity between a set of symptoms which two medicines relates to; and, determining synergistic effect of two medicines according to a product of the synergy factor and similarity factor. Proposed is constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining the synergistic effect of medicines on the basis of the genes. The present invention also relates to medicine composition of sinomenine and honokiol and of sinomenine and luteolin, each with anti-angiogenesis effect and having good synergistic effect.

Abstract: The disclosed technology relates to the creation of creating an indexing system. The indexing system is created by selecting a macromolecule structure and determining a reference mass and an adjacent ion mass. The reference mass and the adjacent ion mass associated with the macromolecule structure are then stored in the indexing system.

Abstract: An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.

Abstract: A NOx estimation system includes an operating mode determination module that determines an operating mode of an engine, and an emission prediction module. The emission prediction module estimates NOx emission based on the operating mode, a plurality of sensed parameters, and a map. The map correlates the plurality of sensed parameters to the NOx emission based on the operating mode.

Abstract: A turbidity measuring device for determining the concentration Kj of a substance Sj in a medium includes measuring arrangements, in which the intensities of scattered light at different angles are registered and convertable into current values of at least a first measured variable M1 and a second measured variable M2, which have different dependences on the concentration Kj of a substance Sj (Mi(Kj)=fij(Kj)). The turbidity measuring device has stored for the measured variables Mi for a number of substances Sj calibration functions gij, with which, in each case, a concentration of a substance Sj is determinable (Kj=gij(Mi)). The turbidity measuring device further includes a computing unit, which is suitable for evaluating the ascertained concentration values gaj(Ma), gbj(Mb), wherein a?b, for different substances Sj as regards their plausibility and so to identify a plausible substance Sj, or to check the plausibility of an earlier identified or predetermined substance Sj.

Abstract: Methods and devices to detect analyte in body fluid are provided. Embodiments include receiving one or more analyte sensor data, receiving a reference measurement value associated with an analyte level, determining a sensitivity parameter based on the received one or more analyte sensor data and the reference measurement value, performing a probability analysis based on prior analyte sensor data to determine presence of signal attenuation, and generating an output value based on the probability analysis.

Abstract: A fluorimetric system, apparatus and method are disclosed to measure an analyte concentration in a sample. A sensor reagent housing is also disclosed which comprises a channel and a porous medium having an analysis chemistry reagent, such as a nucleic acid analysis chemistry reagent. The apparatus and system are portable for field use, with an apparatus housing having a size adapted to fit into a user's hand. An apparatus also includes a sensing chamber and cover, a user interface, a light source, a photomultiplier tube, an amplifier, an A/D converter, a memory, and a processor. In various embodiments, the processor performs a data fitting, determines a sample reaction rate parameter, and determines the analyte concentration from a comparison of the sample reaction rate parameter with stored calibration data. The processor may also generate the calibration data and site-specific offset factors, and modify the calibration data using an offset factor.

Abstract: A concentration determination apparatus may determine a concentration of a target component in an arbitrary layer of an observed object including a plurality of light scattering medium layers. The concentration determination apparatus may include an irradiation unit, light scattering medium layer selection unit, a light receiving unit, a light intensity acquisition unit, an optical absorption coefficient calculation unit, and a concentration calculation unit.

Abstract: A method for shortening a waiting time from the setting of a sample in a chamber to the stabilisation of the intensity for a secondary ion for SIMS analysis (mass analysis of the secondary ion) using a raster variation method is provided. By approximating so that the difference between time-lapse variations in intensities of the secondary ions sequentially measured for irradiation densities of two different primary ions becomes constant, a method capable of carrying out an accurate measurement of the concentration of an impurity in consideration of background noise despite time-lapse variations in the intensities of the secondary ions is provided.

Abstract: A method is provided for the determination of a NOx concentration value upstream of a Selective Catalytic Reduction (SCR) catalyst in a Diesel engine, the engine having an exhaust line, a Diesel Particulate Filter and a NOx concentration sensor downstream of the SCR catalyst, the method including, but is not limited to estimating the NOx concentration value upstream of the SCR catalyst as a function of at least two engine parameters, measuring the NOx concentration downstream of the SCR catalyst, calculating the difference Z(x, y) between the estimated NOx concentration value and the measured value and, in case said difference is higher than a predetermined threshold, correcting the estimated NOx concentration value with a NOx concentration correction value. The NOx concentration correction value is calculated using a correction map that correlates said at least two engine parameters and the difference Z(x, y) with said NOx concentration correction value.

Abstract: A concentration monitor for monitoring a concentration of a plurality of use solutions, each of the plurality of use solutions being, at least, a concentrate in a diluent, each of the plurality of use solutions having a resistivity which varies as a function of both temperature and an amount of the concentrate contained in a given amount of the diluent. A resistivity probe is adapted for use with at least one of the plurality of use solutions for taking a measurement related to the resistivity of the at least one of the plurality of use solutions. A temperature sensor is adapted for use with the at least one of the plurality of use solutions for taking a measurement related to the temperature of the at least one of the plurality of use solutions.

Abstract: A system for providing animal test information is disclosed that comprises: test devices; and a central device communicably connected to the test devices, wherein each of the terminal test devices comprises: an input receiving section for receiving input of attribution information of a sample; a measurement section for measuring the sample and acquiring a measurement result; an information transmitting section for transmitting a data set of the attribution information and the measurement result to the central device, wherein the central device comprises: an information receiving section for receiving the data set; a data storage for storing a plurality of the data set; a standard value calculation section for calculating a standard value to be used for determining a treatment of an animal, based on a plurality of the measurement result included in a plurality of the data set which have common attribution information.

Abstract: The invention relates to a method for the qualitative and quantitative analysis of samples by optical emission spectroscopy with laser excitation (18), using a database created on single-element aqueous solutions all having the same pure element concentration, this database containing, for each element, the wavelengths of the emission lines and their respective intensities.

Abstract: The concentration of air or other agents in a fluid delivery line is determined by monitoring agent signals and processing those agent signals along with information regarding the age of each agent signal. The processor determines a primary agent concentration value based on the received agent signal values, with the primary agent concentration value determined by giving greater weight to more recent agent signal values. Where the primary agent concentration value exceeds a primary threshold value, an alarm signal may be activated. The processor also may determine a secondary agent concentration value, which may be determined from the actual agent signal values instead of the weighted agent signal values. Where the secondary agent concentration value exceeds a secondary threshold value, an alarm signal may be activated.

Abstract: Provided herein are systems and methods capable of detecting and discriminating and/or classifying hazardous biological agents or other hazardous agents. In one aspect, a system measures electromagnetic energy scattered by a material at the different polarizations states and wavelengths. The system then combines the measured electromagnetic wavelengths at the different polarization states and wavelengths into different combinations to produce input parameters for a classifier. The input parameters include both depolarization and wavelength-dependent elastic backscatter measurements of the material illuminated by transmitted electromagnetic energy. The combination of wavelength dependent depolarization measurements and wavelength dependent backscatter measurements provides a unique capability to classify (or discriminate) based on size, shape, and refractive index.

Abstract: A data analysis method includes automatically generating a set of curve fits for a data set from a mass spectrometer. The set of curve fits includes a plurality of suggested curve fits, each associated with a curve fit equation type. For each suggested curve fit, a fit metric is generated that indicates how well the curve fit matches the data set. Thereafter, a user interface is displayed that includes a table of user selectable suggested curve fits for display. A default suggested curve fit having a highest fit metric is displayed. A user override selection may be received for displaying at least one of the suggested curve fits in the table. The set of suggested curve fits under consideration can be filtered to conform with user requirements.

Abstract: Quantitation is performed using data from a mass spectrometer. A calibration ion mass spectrum is acquired for each of a plurality of known quantities of a material. From the calibration spectra a plurality of ions that identify the material is determined, and for each ion of the plurality of ions a linear range and linear function are determined. A sample ion mass spectrum is acquired for an unknown quantity of the material. A sample intensity is measured for each ion of the plurality of ions from the sample spectrum. After acquiring the sample spectrum, one or more ions are selected from the plurality of ions such that the sample intensity of each of the one or more ions is within a linear range of the ion. The unknown quantity is calculated from the sample intensities and linear functions of the one or more ions.

Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.

Abstract: The invention relates to a method for determining the ignitability of fuel, particularly of diesel, biodiesel, gas-to-liquid or biomass-to-liquid fuel, with an unknown fuel quality for an internal combustion engine. Provision is made for the density of the fuel to be ascertained and for the ignitability to be derived from this.

Abstract: Selectivity of a measurement from a mass spectrometer is improved by selecting an extracted ion current window for the measurement after data acquisition. A plurality of mass spectra are acquired over a period of time. A first extracted ion current window is selected and from the plurality of mass spectra a first intensity as a function of time is calculated for an ion using the first extracted ion current window. A second extracted ion current window is selected and from the plurality of mass spectra a second intensity as a function of time is calculated for the ion using the second extracted ion current window. A first signal-to-noise ratio of the first intensity is compared with a second signal-to-noise ratio of the second intensity. If the second signal-to-noise ratio is greater than the first signal-to-noise ratio, the second intensity as a function of time is used for the measurement.

Abstract: A method of analysing particles of a material which include a constituent is disclosed. The method comprises the steps of exposing particles of the material to x radiation having a range of x-radiation energies, detecting x-radiation intensities at two different energy levels transmitted through the particles, and determining the concentration of the constituent in particles from the detected intensities.

Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Abstract: A method for discriminating particle groups comprises generating, by a particle analyzer, a particle characteristic distribution histogram in which the abscissa indicates respective channels for representing the characteristics of the particles, and the ordinate indicates the particle count; setting a valid area selection height in the particle characteristics distribution histogram; and generating an equivalent negative histogram based on the set height and the particle characteristic distribution histogram.

Abstract: In certain embodiments, estimating air in a cooling system includes measuring a property that can be used to estimate the air to yield a plurality of measurements. The measurements are performed for different heat loads and for different concentrations of non-condensable gas in the cooling system. The measurements are stored a data set.

Abstract: Trigger-based application control may be provided. A work implement may receive an application trigger comprising a location-based condition. In response to determining that the work implement has entered the work area associated with the location-based condition, an application associated with the work implement may be received and initialized.

Abstract: The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.

Abstract: There is provided a combustible gas detection apparatus with a gas sensor and a control device. The gas sensor includes first and second heating resistors each having a resistance that changes depending on a combustible gas concentration of gas under measurement. The control device includes an energization control section that alternately energizes the first and second heating resistors, a first calculation section that calculates a first calculation value responsive to the combustible gas concentration based on a voltage across the first heating resistor during energization of the first heating resistor, a second calculation section that calculates a second calculation value responsive to the combustible gas concentration based on a voltage across the second heating resistor during energization of the second heating resistor, and an anomaly judgment section that judges the occurrence of an anomaly in the first heating resistor by comparison of the first and second calculation values.

Abstract: A thermal diffusivity measuring system including a measuring mechanism for measuring a radiation coefficient or a value for thermal conductivity for a mixed gas measured when the heater element has produced heat at a plurality of temperatures; a thermal diffusivity calculating equation storing device storing a thermal diffusivity calculating equation using the radiation coefficients or the thermal conductivities for a plurality of heat producing temperatures as independent variables and uses the thermal diffusivity as the dependent variable; and a thermal diffusivity calculating portion calculating a value for the thermal diffusivity of the mixed gas being measured through substituting the values of the radiation coefficients or the thermal conductivities of the mixed gas being measured, for the plurality of heat producing temperatures, for the independent variables of the radiation coefficients or thermal conductivities, for the plurality of heat producing temperatures, in the thermal diffusivity calculating

Abstract: A computer implemented method, apparatus, and computer program product for generating olfactory cohorts. Olfactory data is received from a set of chemical sensors. The olfactory data describes a set of olfactory patterns for an air sample. The olfactory data is processed to identify attributes of particles in the air sample and generate digital olfactory data. The digital olfactory data comprises metadata describing the attributes of the particles in the air sample to form digital olfactory data. A set of olfactory cohorts is generated using the attributes in the digital olfactory data.