Abstract: Syringe (1) including a cylinder (2) and a piston (4), in which the outlet end (6) of the cylinder (2) is integrated with a valve male luer lock connector (7).

Abstract: A syringe assembly having a collapsible or pivotable plunger rod with magnification properties is provided. In a pre-use or packaged state, the plunger rod is positioned substantially parallel to a barrel of the syringe assembly resulting in the syringe assembly having a reduced length and a smaller packaging footprint. The smaller packaging footprint allows for reduced storage space of the syringe assembly. Upon removal from a packaging and/or a storage space, the plunger rod can be slid or pivoted toward a proximal end of the syringe barrel and locked into place such that the syringe assembly is ready for use. The plunger rod can be shaped to provide magnification to indicia of the syringe barrel and/or contents. Alternatively, a separate magnification member can be associated with the plunger rod and/or secured about the syringe barrel.

Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.

Abstract: An auto-injection device has a housing with a medicament container disposed within; a dose setting mechanism for setting a dose of a medicament; a drive nut and a plunger rod operably connected, with an energy accumulator operably connected to the dose setting mechanism; and an activating mechanism and a positioning mechanism operably connected to the plunger rod for locking the plunger rod from being displaced. The positioning mechanism includes a locking nut arranged to cooperate with fixed, flexible locking features for locking the locking nut from rotation. A resilient member arranged inside the plunger rod is configured to allow the plunger rod to be resiliently and axially displaced when the locking nut is unlocked.

Abstract: A syringe assembly includes a syringe barrel having an exterior surface, an inside surface defining a chamber, an open proximal end, a distal end, and an outlet disposed adjacent the distal end in fluid communication with the chamber; and a plunger assembly disposed at least partially within the syringe barrel. The plunger assembly includes an elongated plunger rod and a plunger head. The elongated plunger rod is associated with the plunger head to move the plunger head within the chamber of the syringe barrel through an injection cycle. The plunger rod is adapted to move from a collapsed position extending alongside the exterior surface of the syringe barrel to an extended position engaging the plunger head to move the plunger head through the injection cycle.

Abstract: A system (10, 200) and corresponding method for introducing a drug delivery device (18, 218) through at least part of a biological barrier starts with the drug delivery device (18, 218) deployed within a channel of a hollow needle (12, 212). The hollow needle is inserted into the biological barrier and the drug delivery device is pushed forward by a suitable plunger. The drug delivery device is preferably anchored to the biological barrier through a radially expanding retention arrangement (36, 36?, 36a), and is preferably filled with a liquid drug after deployment via a filling needle (24, 222) extending within the channel of the hollow needle (12, 212).

Abstract: The present invention relates to an injection device (1) comprising: -a body (3) receiving a product, having a needle (7) and a piston (5) attached to a piston rod (8) movable between a storage position and an end-of-injection position, -a sleeve (6) for protecting the needle (7), movable between an initial position, where the needle (7) is uncovered, and a final position, where the needle (7) is covered, -biasing means (26) for moving said sleeve (6) from its initial position to its final position, -immobilization means (16, 31) for keeping said sleeve (6) in its initial position, characterized in that: -said piston rod (8) comprises a first portion (9) and a second portion (10), said second portion (10) being able to switch between a locked position, in which said second portion (10) is fixed to said first portion (9) and an unlocked position, in which said second portion (10) is movable with respect to said first portion on a predetermined distance along the longitudinal axis of said piston rod (8).

Abstract: The present invention relates to a syringe, particularly to a small volume syringe such as a syringe suitable for ophthalmic injections.

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a collection vessel by a flexible conduit. The collection vessel can comprise an impermeable or permeable collection vessel. The collection vessel is contained within a collection container, and can feature a tapered end. An air inlet may be provided in the flexible conduit and/or in a collection canister lid.

Abstract: A safety syringe that effectively prevents the administration of an injection in excess of a maximum injection pressure, and that provides a clear, immediate tactile feedback to the practitioner each time a maximum injection pressure is exceeded. The practitioner is provided a predetermined number of attempts to inject fluid without exceeding the maximum injection pressure, each time receiving a direct tactile feedback in the form of a ratcheting click within the plunger assembly of the syringe. After a final attempt, the next over-pressure event causes a disconnect between the thumb plate of the syringe and the piston that engages the fluid within the syringe barrel, positively prevent a potentially harmful injection. In an illustrative embodiment, the plunger assembly includes a distal portion connected to the piston and a proximal portion, connected to the thumb plate.

Abstract: A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed.

Abstract: An injection device including a volume for accommodating a product for administration, a piston for acting upon the product within the volume, and a stopper which can be arranged between an end of the piston facing the product and the product within the volume, wherein the piston includes a piston head configured to be sealed in a gas-tight manner, the piston head being separate from the stopper such that a negative pressure or vacuum region can be developed between the piston head and the stopper.

Abstract: Drug delivery device, comprising a body unit having a first opening and a second opening, a plunger arranged such that its distal end is positioned inside the body unit, wherein the plunger is moveable in the distal direction with respect to the body unit, a needle assembly, with a proximal end and a distal end comprising a needle, wherein the proximal end of the needle assembly and the distal end of the plunger are configured such that they can get into a vacuum connection.

Abstract: A medical delivery system wherein one of a container and a dosing assembly comprises a first fastening means (116) and the other one of the container and the dosing assembly comprises a second fastening means (114); and wherein the second fastening means is adapted to move at least a part of the first fastening means in a radial direction upon rotation of the container in a first rotational direction relative to the dosing assembly, whereby the first and second fastening means engage such that the container and the dosing assembly are locked for relative translational movement. A container and a dosing assembly for use in the medical delivery system.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: An injection system includes a syringe, which preferably includes larger and smaller inner diameters, and a plunger. A wiper sidewall of the plunger defines a cavity, into which a plunger shaft of the system is inserted, for moving the plunger, within the syringe, for fluid injection. The plunger includes a feature for engaging the shaft, and the sidewall preferably includes a expandable-contractible portion, in which the feature is formed. When the plunger is initially mounted within the larger inner diameter of the syringe, the portion of the sidewall is expanded and the feature of the plunger does not operably engage the inserted shaft. When the shaft moves the plunger into the smaller inner diameter of the syringe, the portion of the sidewall contracts and the feature operably engages the shaft. An optional deformable end wall of the plunger may be spaced apart from a distal terminal end of the inserted shaft.

Abstract: A injection device may be disclosed. The device may include an outer casing, a needle, and a plurality of projections surrounding the needle. The needle may be adjustable between a first position and a second position. A vibration motor may be disposed within the device to impart vibration to the device. Decorative indicia may be provided on the exterior of the device. In use, the injection device may provide sensory stimuli to distract from the pain and the anticipation thereof.

Abstract: A syringe with a blocking structure, and the structure includes a one-way engagement unit having a propping portion, a flange extended outwardly from a rod and abutted with a cylindrical body, and a flexible bracket extended outwardly from the rod and isolated from the propping portion, and the flexible bracket has an external diameter greater than the propping portion. When the rod is moved forward with respect to the cylindrical body to pass through the flange, the flange abuts the flexible bracket to tilt backward. When the rod is moved backward with respect to the cylindrical body, the flange abuts the flexible bracket to tilt the flexible bracket forward, and the propping portion blocks the flexible bracket.

Abstract: The invention is directed to a syringe used to irrigate the ear and remove earwax.

Abstract: A medicine injection device comprises a cartridge having a cartridge barrel and a plunger having a plunger shaft slidable within the cartridge barrel. The cartridge may have, e.g., a pre-filled medicine. The medicine injection device farther comprises a body having a proximal end, a distal end, and a cavity in which the cartridge barrel is disposed. The proximal end of the body may optionally form a finger grip. The medicine injection device further comprises a plunger locking mechanism attached to the proximal end of the body. The plunger locking mechanism comprises a member with an aperture slidably engaged with the plunger shaft. The locking mechanism is configured for preventing the plunger from being removed from the cartridge barrel. For example, the plunger shaft may include a locking stop, e.g., a flange, that engages with the aperture in an interference arrangement.

Abstract: This syringe has an outer tube, a gasket, and a pusher. The pusher is provided with: a tubular holding part which covers at least a part of an outer surface of the outer tube and is movable relative to the outer tube in the longitudinal direction thereof; and a pressure part which is connected with the holding part, is inserted into the outer tube, and moves the gasket to the distal side of the outer tube by distally a movement of the holding part relative to the outer tube. In addition, between the holding part and the outer tube, a guide part is provided which guides the movement of the holding part relative to the outer tube.

Abstract: An injection device having parts, the relative movement of which causes the active substance to be injected. For this purpose, a receptacle, into and in which a carpule/syringe can be inserted and mounted, is retained in a housing, the receptacle can be moved by means of a carriage, and a plunger that applies a force to the piston/s of the carpule/syringe is movably retained in the receptacle. A traction rope which is deflected by means of a roll mounted on the carriage is provided for performing the pricking stroke, injection stroke, and retracting stroke. One end of the traction rope is connected to the receptacle while the other end thereof is connected to a tension spring that is retained on the housing. Mechanisms between the housing, the receptacle, the plunger, and the carriage control the reciprocal coupling thereof to the traction rope.

Abstract: The invention relates to a detent mechanism for controlling translation between two components in a longitudinal direction, the detent mechanism comprising a resilient beam on one of the components and a rhomboid ramp member on the other component, the resilient beam being essentially straight when relaxed and having a first beam head and arranged to interact in a ramped engagement with respectively one of two ramps, each ramp on one longitudinal side of the rhomboid ramp member in such a manner that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction when a predetermined value of the translative force, at least depending on the resilience of the resilient beam, is overcome so as to allow the first beam head to travel along one transversal side of the rhomboid ramp member on continued relative translation of the components, wherein the resilient bea

Abstract: An Injection device for administering a dose of a liquid medicament to a patient comprises a syringe containing the dose of the medicament a hollow injection needle adapted to penetrate the skin of the patient, a stopper translatably disposed within the syringe, a plunger connectable to the stopper and translatable in at least a proximal direction to displace the stopper in the proximal direction and a releasable noise component capable of, upon release, generating an audible and/or tactile feedback. The proximal displacement of the stopper causes the dose of the medicament to be expelled through the hollow injection needle. The noise component is released when the plunger reaches a position relative to the syringe in which the stopper is located in proximity of a proximal end of the syringe. The released noise component impacts on at least one component of the injection device to generate the audible and/or tactile feedback indicating the end of the injection.

Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: A seal member is configured to seal a chamber of a drug delivery device which is suitable to contain a drug, wherein the seal member comprises a diaphragm.

Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

Abstract: The delivery systems of the present disclosure are configurable to administer either single-dose or multiple-doses of one or more substances to a user, for example to the eye, nose, mouth, ear or rectum of the user. The precise and repeatable dosing features of the presently disclosed delivery systems overcome many of the disadvantages associated with known methods for dispensing substances to, for example, the eye of a user. The delivery systems administer precise doses of a substance to a precise location from unit dosage forms that may be single-dose or multiple-dose unit dosage forms, which may be externally or internally pierced.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: A fluid syringe of the type used with fluid infusion devices is presented here. The fluid syringe generally includes a barrel, a piston, and a check valve seal. The barrel has an interior wall and a sealed main fluid chamber. The piston is slidably coupled within the barrel, and the piston has a piston seal forming an interference fluid seal against the interior wall. The check valve seal is coupled to the piston, and it is located between the piston seal and the main fluid chamber. The check valve seal forms an interference fluid seal against the interior wall when the piston is unloaded, and it disengages the interior wall to allow gas flow from the main fluid chamber toward the piston seal when the piston is loaded.

Abstract: Dual syringe injector systems are disclosed. An injector system may include a housing, a first and a second drive member within the housing and operable to engage a plunger of a first and a second syringe, respectively, a first and a second syringe retaining mechanism associated with the housing and adapted to engage the first and second syringe, respectively, a pressure sensing device connected the first and/or the second drive member and adapted to measure fluid pressure within a syringe when the syringe is engaged by a drive member, and a control system operably attached to the first and second drive members and the pressure sensor sensing device. The control system may be configured to individually control the first and second drive members simultaneously. The control system may be capable of causing sequential or simultaneous injection.

Abstract: The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.

Abstract: Methods and apparatus for a syringe adapter. In one embodiment, an adapter/cap assembly is threadably engaged to a syringe for enteral feeding applications. The adapter cannot be removed from the syringe to prevent the syringe from being used for IV applications.

Abstract: The invention relates to an autoinjector (1) comprising: a housing (30, 30a, 30b), a container movable within said housing between an initial position and an insertion position, said movement being prevented when the container is in its passive state, and permitted when the container is in its active state, and a safety shield (40) movable with respect to said housing between a first position and a second position, said movement placing the container in its active state, first retaining means (61, 52) for maintaining said container in its passive state, characterized in that it comprises first deactivating means (50, 51), capable of rotating with respect to said first retaining means from a first position, in which said first retaining means maintain said container in its passive state, to a second position, in which said first retaining means allow the passage of said container in its active state, said rotation being caused by movement of said safety shield from its first position to its second position

Abstract: A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. Thus, the vascular puncture wound is sealed by natural blood clot formation.

Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.

Abstract: A syringe is disclosed. The syringe may include a syringe body, a first slot formed in the syringe body, a first sleeve covering the first slot, a thumb grip including a first slot guide disposed in the first slot, the thumb grip shaped to slide from a first position near the distal end of the syringe body toward a second position near the proximal end of the syringe body, and a plunger disposed in the fluid chamber of the syringe body. The plunger is configured to move towards the proximal end of the syringe body in response to pressure applied by a user to the thumb grip and includes a first plunger slot guide.

Abstract: The present invention relates to damper for a medicament delivery device, which device comprises a container containing medicament, a stopper arranged in said container and movable for expelling said medicament through a dose delivery means, a plunger rod having opposing proximal and distal ends and capable of acting on said stopper, and force means capable of exerting a force on said plunger rod, wherein said damper comprises a tubular sleeve having opposing proximal and distal ends; said sleeve comprises a compartment formed by a closed end wall at the proximal end of the sleeve and the proximal end of the plunger rod which is positioned in an open end at the distal end of the sleeve; and wherein said compartment comprises a sealable and resilient pad, a fluid, and at least one passage for expelling said fluid in an annular space between said sleeve and an inner wall of said container, thereby creating a dampening force, upon movement of said plunger rod.

Abstract: The present invention relates to a cartridge holder assembly for a drug delivery device comprising of a cartridge holder adapted to receive a cartridge filled with a medicament to be dispensed by the drug delivery device, wherein the cartridge holder comprises a first through opening at a distal end section to receive a piercing element adapted to penetrate a sealing member of the cartridge, a support structure adjacently arranged to the first through opening; and a constriction member arranged between the support structure and a distal end face of the cartridge and having a second through opening smaller than the first through opening.

Abstract: Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs.

Abstract: An intraocular insertion device capable of safely performing discharge operation of a lens by a simpler construction. The intraocular lens insertion device has a body provided with a lens placement section where the lens is placed and a tube section for inserting the lens into an eye and has a plunger for discharging the lens placed on the lens placement section. The lens placement section has an upper holding member and a lower holding member. The upper holding member has a rib projecting on advancement axis A, to the lower side of the lens placement section. The lower holding member has a U-shaped cross-section and is constituted of a left and right pair of uprising sections and a pressing section uniting the uprising sections at their lower ends.

Abstract: The invention relates to a piston rod for an injection device, comprising a first and a second legs, each leg being foldable on itself and comprising a proximal region, said piston rod being in one of a folded position and an unfolded position, said piston rod comprising coupling means for coupling the proximal region of the first leg to the proximal region of the second leg when said piston rod is in said unfolded position. The invention also relates to a kit comprising said piston rod.

Abstract: A plunger activated capping system is disclosed which includes a syringe body defining a fluid reservoir, a plunger assembly including a plunger rod and a sealing member supported on the plunger rod, and a luer cap releasably secured to a distal end of the syringe body. The luer cap includes a luer-type connector member and a fluid outlet. A luer cap plug is releasably supported on a distal end of the plunger rod at a location distally of the sealing member. The luer cap plug is movable into engagement with the luer cap to seal the fluid outlet of the luer cap upon advancement of the plunger assembly from a retracted position to an advanced position. The plunger assembly is configured to effect disengagement of the luer cap from the distal end of the syringe body when the plunger assembly is moved to the advanced position.

Abstract: A syringe assembly includes a syringe barrel having an inside surface defining a chamber and an outlet. A plunger assembly is disposed within the syringe barrel and includes an elongate plunger rod having a distal end surface, a plunger head having a distal sealing surface and a proximal end surface having a continuous perimeter, and a breakable neck portion integrally connecting the plunger rod and the plunger head. A retaining ring lock is disposed on the inside surface of the barrel and defines an engagement surface about a perimeter of the chamber. The retaining ring lock is adapted to engage and retain the plunger head in a locked position within the chamber. The engagement surface of the retaining ring lock engages the continuous perimeter of the proximal end surface of the plunger head in a perimetrical engagement when the plunger head is in the locked position.

Abstract: An injection control device having a metered/controlled injection rate, that is proportional to the rate of withdrawal/injection—suitable for cosmetic as well as other applications—is described. For an injection mode, after the cannula is advanced into an object, the cannula is withdrawn to create a tract or tunnel within the targeted area. As the cannula is withdrawn, filler material in the injection control device is uniformly deposited into the tract or tunnel via the automatic metering system. The automatic metering system incorporates a syringe activating mechanism coupled to a gearing system which is capable of proportioning the deposition (or sucking) rate to the retraction/injection rate of the cannula. Accordingly, more consistent and uniform distribution (or harvesting) of material can be achieved with less cannula passes as well as requiring less dependence on the skills of the practitioner of this device.

Abstract: A syringe device and injector system including a vent for relieving a vacuum within a syringe is provided. Embodiments provide a syringe device including a reservoir having a sidewall. The reservoir includes a dispensing distal end a proximal end. The syringe device also includes a piston in movable sealing engagement with the sidewall. Furthermore, the sidewall defines a vent extending from the proximal end of the reservoir. The vent is configured to interrupt the sealing engagement between the piston and the sidewall so as to allow a gas to enter the reservoir through the proximal aperture and past the piston member as the piston member is moved from the distal end to the proximal end of the tubular aperture.

Abstract: Medical devices, methods and kits are described. An exemplary medical device comprises a catheter that has a catheter wall and defines a catheter lumen, a bend, and a coil disposed distal to the bend. The catheter defines one or more apertures that extend through the catheter wall and are in communication with the catheter lumen.

Abstract: An extendible plunger rod for use with a syringe is provided. Example plunger rods may include an outer plunger rod with a proximal end and a distal end, the outer plunger rod having an inner cavity; an inner plunger rod, housed at least partially within the inner cavity of the outer plunger rod; a compression spring disposed within the inner cavity of the outer plunger rod and between the proximal end of the outer plunger rod, and the inner plunger rod, the compression spring configured to exert force tending to push the inner plunger rod in a direction distal to the outer plunger rod; and a locking mechanism, the locking mechanism configured to prevent movement of the inner plunger rod relative to the outer plunger rod while both the inner and outer plunger rods are depressed into a syringe body, until the outer plunger rod has been depressed at least a first predetermined distance into the syringe body.