Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A pair of clips receive a barrel of the syringe. The clips are on a housing receiving a pre-filled cannister of a topical numbing agent and including a chamber. The cannister includes an aerosol dispensing valve actuated by a button which when pressed moves the cannister with respect to an actuator for the valve.

Abstract: A topical anesthetic dispenser is releasably attachable to a pre-filled disposable syringe. A clip receives a barrel of the syringe. The clip includes a receptacle portion receiving a pre-filled cannister of a topical numbing agent, wherein the cannister includes a generally cylindrical chamber portion receivable within the receptacle portion of the clip and a distal neck portion having an outlet allowing contents of the cannister to be dispensed. A dispenser attached to the distal neck portion of the cannister includes an elongated flexible tube surrounded by a rigid tube for at least a portion of a length of the elongated flexible tube. A pivotable lever carries a tube compressor including a pinching member extending through an opening in the rigid tube and spring biased to a position at which the pinching member pinches closed an elongated passageway through the flexible tube.

Abstract: A retractable safety syringe may have a ferrule and needle which are selectively removeable from a distal end of a syringe body. In particular, the ferrule may have an annular flange. A wedge element may be frictionally engaged to the ferrule and a distal end of the syringe body. To retract the needle into the syringe body, a punch of a piston displaces the wedge element off of an annular flange of the ferrule. At about the same time, longitudinally offset tabs engage an annular flange and retract the needle into the syringe body via a retraction force created by a variable vacuum compartment or tension member. Alternatively, the ferrule and needle may be temporarily fixed to the distal end of the syringe body via a detent and/or o-ring which engages a lower undercut groove and an upper undercut groove of the ferrule. An annular ring of the piston may have longitudinal offset tabs which engage an annular ring of the ferrule.

Abstract: A syringe drive device 1 includes: a syringe holding section 3; a piston manipulating section 4; and a display section 6. An outer tube 202 of a syringe 201 is detachably held by the syringe holding section 3. A piston 203 of the syringe 201 is detachably engaged with the piston manipulating section 4. The piston manipulating section 4 moves in a direction in response to an operation of operation buttons 8A and 8B, and the piston 203 is thereby moved in a direction where the piston is pushed into or pulled out from the outer tube 202. An internal pressure of a medicinal solution container punctured with an injection needle 204 attached to the outer tube 202 of the syringe 201 is measured and displayed on the display section 6.

Abstract: The present invention relates to a medicament delivery device comprising a generally elongated housing comprising a proximal part (10) and a distal part (12); a medicament cartridge (18) comprising a proximal opening closed by a septum (30), an axially movable distal stopper (26), and a first enclosure (20) wherein a liquid and a gaseous fluid are enclosed; a medicament delivery member (36) attachable to said proximal part (10) and having a non-delivery end (34); a medicament cartridge holder (16) wherein the medicament cartridge is coaxially arranged, said cartridge holder being arranged coaxially movable inside said proximal part and comprising holding means (38, 40) capable of holding said medicament cartridge holder (16) in a non-activated position in which said cartridge holder is releasebly engaged to said proximal part and in which a predetermined distance is present between the septum and the non delivery end; a manual pressure mechanism arranged to be moved from a non-pressure position to a pressure

Abstract: Low-dosage syringes for use in administering small dosages of medicine are disclosed. An illustrative low-dosage syringe can include an elongate syringe barrel having an interior chamber adapted to receive a supply of fluid, a plunger member slidably disposed within the interior chamber, and a tip member defining an inner lumen in fluid communication with the interior chamber. The configuration of the syringe barrel, including the wall thickness of the barrel relative to the outer diameter and to the length of the barrel, may permit small dosages of medicine to be accurately administered while also allowing the user to easily manipulate the syringe barrel with their fingers.

Abstract: A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of the pistol housing, the needle direction control mechanism, the boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

Abstract: A dispenser assembly for liquid products is disclosed. Such an assembly may include an elongated barrel, and an elongated plunger having a flexible sealing lip disposed at an end thereof. The sealing lip may have an outer diameter in a relaxed state that is greater than an internal cross-sectional diameter of the barrel. When the plunger and barrel are actuated axially relative to one another, the sealing lip flexes inwardly and provides the sole contact between the plunger and the barrel.

Abstract: An I.V. flush syringe assembly includes a barrel having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end with a passageway therethrough in fluid communication with the chamber. An elongate plunger having a proximal end, a distal end and a stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for drawing fluid into and out of the chamber by movement of the stopper relative to the barrel. The plunger includes anti-reflux structure for minimizing stopper deflection when fluid has been delivered from the chamber and the stopper is being forced against the distal end of the chamber.

Abstract: A medicament delivery device includes a housing; a drive force mechanism slidable in the housing's distal part; a member connected to the drive force mechanism for holding it in a loaded state and axially movable in relation to the distal part a predetermined distance by the housing's proximal part when the parts are moved toward each other; and an actuation member to be biased in relation to the distal part from a non-operating position partially protruding from the distal part to an operating position confined within the distal part. The actuation member can release the drive force mechanism from its loaded state, and is resiliently connected to the distal part such that it is always recoiled after being biased regardless of whether the actuation mechanism is released. The drive force mechanism is released only after the holding member moves and the actuation member is biased from non-operating to operating position.

Abstract: An I.V. flush syringe assembly includes a barrel having an inside surface defining a chamber for retaining fluid, an open proximal end and a distal end with a passageway therethrough in fluid communication with the chamber. An elongate plunger having a proximal end, a distal end and a stopper is slidably positioned in fluid-tight engagement with the inside surface of the barrel for drawing fluid into and out of the chamber by movement of the stopper relative to the barrel. The plunger includes anti-reflux structure for minimizing stopper deflection when fluid has been delivered from the chamber and the stopper is being forced against the distal end of the chamber.

Abstract: An assembly for a drug delivery device is provided, comprising a housing, a rotation member adapted and arranged to be rotated in a first and in a second rotational direction with respect to the housing in an operational mode of the assembly, a drive member which is configured to mechanically cooperate with the rotation member such that the drive member follows rotation of the rotation member when the rotation member is rotated in the second rotational direction and such that the rotation member rotates with respect to the drive member when the rotation member is rotated in the first rotational direction, and a piston rod. The assembly further comprises at least one biasing member which is adapted and arranged to provide a force tending to bring the rotation member and the drive member out of mechanical cooperation in the operational mode. The assembly is switchable from the operational mode into a reset mode.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.

Abstract: A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation

Abstract: Flush syringe assemblies capable of creating pulsatile movement of the plunger rod as it moves in the distal direction within a syringe barrel, while preventing overpressurization of the cathether are provided. An exemplary flush syringe assembly includes a syringe barrel with a first pulsing element and a chamber with flush solution, a plunger rod with a stopper and a second pulsing element that interacts with the first pulsing element to provide an engagement force that causes pulsatile movement of the plunger rod and a thumb press slidably attached to the plunger rod with a pulse control element. The pulse control element is compressible to create a compression force that is greater than the engagement force of the first pulsing element and the second pulsing element.

Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.

Abstract: A pen injection device designed for use with dual or multi-chamber cartridges 14, is provided with an extended length plunger 24 having a non-drive portion 24? on its forward end and the usual screw-threaded drive portion 24? on its rearward end. This arrangement allows the plunger to be pushed forwardly while the dosing drive mechanism is disengaged to effect a reconstitution movement of the rearward bung 18? in the cartridge. Thereafter the threaded portion on the plunger 24? engages the drive mechanism to allow metered dosing.

Abstract: This invention provides a device for delivering substances such as medical implants and tissues. The device comprises a mandrel and a mandrel guide whereby substances are delivered by retracting the mandrel guide relative to the mandrel. Included among the various embodiments are devices specialized for delivering retinal pigment epithelial (RPE) cells or nanoplates containing RPE cells to the retina, devices with precise control of delivery, devices with specialized mandrels and/or nozzles, and multifunctional devices adapted to provide additional functions such as infusion and/or suction, illumination, and diathermy.

Abstract: A syringe assembly is provided comprising a syringe cylinder extending from an opening configured to receive a plunger to an end configured to couple with a needle and/or medical tubing, a cap configured to couple to the end, and barrier material at least partially encompassing the cap and the end. A syringe assembly is provided comprising a syringe cylinder extending from an opening configured to receive a plunger to an end configured to couple with a needle and/or medical tubing, a plunger extending from one end to a seal end, and at least one cap configured to couple to the one end. A syringe assembly is provided comprising a syringe cylinder extending from an opening configured to receive a plunger to an end configured to couple with a needle and/or medical tubing, and a plunger extending from one end to a seal end, the one end of the plunger defining a recess configured to receive at least one cap.

Abstract: A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

Abstract: The present invention provides test or training a cartridge for a drug delivery device as well as a method for resetting of such cartridge, wherein the cartridge comprises: a body of substantially cylindrical shape, a piston slidably disposed in the body in an axial direction, a closure means disposed at an axial end portion of the body, wherein the body, the piston and the closure means confine an interior volume coupled to the exterior via at least one fluid escape channel.

Abstract: A medication delivery device (1) comprises a housing (4) having a proximal end (P) and a distal end (D), a cartridge (3) for holding a medication (M), the cartridge (3) having an outlet (2), a moveable piston (5) being retained within the cartridge (3), a drive member (17) moveable in a proximal direction with respect to the housing (4) for setting a dose of medication (M) to be delivered and in the distal direction with respect to the housing (4) for delivering the dose and a piston rod (10) adapted to drive the piston (5) in a distal direction with respect to the cartridge (3) for delivering the dose. The drive member (17) is releasably coupled to the piston rod (10). The medication delivery device (1) further comprises a resilient member (21) which is arranged to move the drive member (17) in the proximal direction with respect to the housing (4) after dose delivery, thereby reducing pressure of the piston rod (10) on the piston (5).

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with said main body adjacent the closed front end. The core member includes a nose portion having a profile adapted to create a positive seal with an outlet opening of such syringe barrel.

Abstract: A medicament dispensing device including a substantially rigid carpule body which has a dispensing end and an actuation end opposite the dispensing end. The carpule body is substantially tubular and thus defines a carpule bore. The device further includes a plunger operatively disposed within the carpule bore having a plunger actuator near the actuation end of the carpule body and a plunger tip opposite the plunger actuator. The plunger tip and an orifice at the dispensing end of the carpule bore define a medicament volume which may be loaded with a medicament selected to achieve specific therapeutic goals. The carpule body may also include a wound depth scale. The depth scale is typically associated with the dispensing end of the carpule body. Similarly, the medicament dispensing device may include a dosage scale. Also disclosed are methods of dispensing medicaments.

Abstract: A device for delivering an active agent to a tissue (100), comprising; a housing (10) including a reservoir (20) for containing said active agent; a delivery tip (35) being in fluid communication with said reservoir; and, a delivery mechanism (40) capable of delivering a predetermined amount of said active agent and releasing the same upon contact between said delivery tip and said tissue.

Abstract: A syringe flange protector for transmitting an axial force from a drive element to a syringe barrel, the syringe barrel having a flange projecting radially from the barrel; comprising a spacer element that is adapted to be disposed axially rearward of at least part of the flange, and is further adapted to communicate with the drive element through one or more points at a first radial distance from a longitudinal axis of the spacer element, and to transmit axial force from the drive element to the barrel through one or more points at a second radial distance from the longitudinal axis of the spacer element, where the second radial distance is less than the first radial distance.

Abstract: A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape similar to a tampon to facilitate its insertion through the vagina and into the uterus. Positioning of the device centrally in the uterus is accomplished through the use of ultrasound. The chamber is inserted into the tubular inserter. Adjusting the length of the chamber inserted into the tubular inserter controls the amount of tubing released from the apertures in the tubular inserter. Ultrasound is used to ensure the proper placement of each tube at the entrance of each fallopian tube. The plunger is inserted into the chamber and adjustment of the plunger controls the amount of the agent released into the tubes.

Abstract: A device and a method for preparing foam are provided. The device includes a first housing having a first chamber therein and a first movable member positioned at least partially within the first housing. The device also includes a second housing having a second chamber therein, the second chamber being selectively and operably connectable to the first chamber. The second housing further includes a biasing member and a second movable member therein, the biasing member biasing the movable member toward a first end portion of the second housing. The device includes a valve operably connected to the first chamber and the second chamber and movably positionable to selectively control the connection between the first chamber and the second chamber and a handle operably connected to the first movable member and movable to bias the first movable member toward a first end portion of the first housing.

Abstract: A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions.

Abstract: A plunger rod includes: an elongated body formed by a plurality of orthogonally spaced elongated ribs extending along a longitudinal axis; a first ledge adjacent a first end of the elongated body; a second ledge adjacent a second end of the elongated body; and an attachment portion extending from the second ledge. The second end of the elongated body opposes the first end of the elongated body. At least one elongated rib includes a retaining anchor positioned adjacent the second end adjacent the second ledge.

Abstract: Apparatus are disclosed for intraosseous fluid infusion or aspiration of bone marrow of a subject. Particular apparatus include a bone portal (bone-penetrating member) comprising axially-aligned distal and proximal sections. The proximal section extends in a distal direction from a proximate end of the bone portal and the distal section extends in the distal direction from the proximate section to a distal end of the bone portal. The bone portal also comprises a fluid-transport bore extending between a proximal opening in the proximal section and a distal opening in the distal section. At least a portion of the distal section has a cross-sectional area, perimeter, diameter and/or dimension greater than that of the proximal section.

Abstract: An actuating mechanism for a hypodermic syringe comprises a flexible tongue (48) allowing the actuating mechanism to be bent to receive a cartridge (10) of injectant closed at its forward end with a septum (14) and at its rearward end with a slidable bung (18). The forward end of the cartridge (10) is fitted into a socket (36) wherein the tail (34a) of a hypodermic needle (34) pierces the septum (14) to access the injectant. With the cartridge (10) fitted, the tongue (48) is straightened, and a spring clip (50) holds the cartridge (10) in position. A plunger (38) can then be depressed, though a guide (42), to drive the bung (18) forward and make the injection. The cartridge (10), which may be a conventional cartridge of any kind, keeps the assembly rigid in use, and the whole assembly is disposed of after a single use, without dismantling.

Abstract: The present invention provides a syringe device including a needle, a syringe body, and a syringe adaptor between the needle and the syringe body. This syringe adaptor includes a reservoir and a plunger configured to move into and out of the reservoir in a direction perpendicular to the longitudinal direction of the needle. The position and direction of travel of the plunger in the syringe adaptor allows a user of the syringe of the present invention to safely and accurately operate the syringe with one hand.

Abstract: A syringe assembly including a syringe barrel having a first end, a second end, and a sidewall extending therebetween defining a chamber is disclosed. The syringe assembly includes a stopper disposed within the chamber of the syringe barrel and a plunger rod having an inner member engaged with the stopper and an outer member adapted for telescopic movement with respect to the inner member. The plunger rod is transitionable from a collapsed position, in which a portion of the inner member is nested within the outer member, to an extended position, in which the same portion of the inner member extends outside the outer member. The syringe assembly also includes a stop member configured for cooperation with a portion of the syringe barrel, upon relative movement of the outer member with respect to the inner member, to limit the outward travel of the plunger rod from the syringe barrel.

Abstract: A syringe assembly includes a syringe barrel defining a chamber, a stopper disposed within the chamber, and a plunger assembly. The plunger assembly includes an elongated plunger rod, a housing, and a handle portion connecting the plunger rod and housing. The plunger assembly transitions from a first position disposed about the syringe barrel, to a second position with the plunger rod engaged with the stopper. Transition of the plunger assembly includes rotational engagement of the plunger rod and stopper.

Abstract: A syringe assembly for use as a pre-filled syringe is disclosed. The syringe assembly includes a syringe barrel defining a chamber and having a stopper disposed therein. A plunger rod includes an inner member engaged with a portion of the stopper and an outer member adapted for rotational advancement with respect to the inner member to axially displace the outer member with respect to the inner member. The plunger rod is transitionable from a collapsed position in which a portion of the inner member is nested within the outer member, to an extended position in which the same portion of the inner member extends outside the outer member. The inner member includes a radial extension and the outer member defines a helical track adapted to receive the radial extension therein.

Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. Also described are methods of disinfecting vascular access devices.

Abstract: A syringe assembly including a plunger rod separate and detached from a syringe barrel and a packaging member, the plunger rod having a sealing member and the packaging member having a first compartment and a second compartment is disclosed. With the syringe barrel received within the first compartment and the plunger rod received within the second compartment, the sealing member of the plunger rod seals the syringe barrel and the plunger rod within the packaging member. In this manner, the syringe assembly is placed in the packaging member in a manner that allows for reduced storage space of the syringe assembly. In one embodiment, the syringe assembly includes an engagement portion connected to the plunger rod and a stopper slidably disposed within the interior of the syringe barrel, the engagement portion operable to secure the plunger rod to the stopper.

Abstract: An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.

Abstract: A syringe assembly having an exterior surface and defining a chamber having a stopper disposed therein is disclosed. The syringe assembly includes a plunger assembly having an elongated plunger rod and a handle portion connected thereto, the plunger rod including a depending leg and at least one hinge connecting the depending leg with the handle portion. The plunger rod is adapted to transition from a collapsed position, in which at least a portion of the depending leg extends along at least a portion of the exterior surface of a syringe barrel, to an extended position in which at least a portion of the depending leg engages the stopper. The at least one hinge maintains the depending leg substantially parallel to a longitudinal axis of the syringe barrel in both the collapsed position and the extended position.

Abstract: A syringe assembly includes a syringe barrel defining a chamber and having a stopper disposed within the chamber, a sleeve having a first end and a second end and extending at least partially about the syringe barrel, and a cap associated with a second end of the sleeve. The syringe assembly also includes a plunger rod having a first end associated with the cap and a second end, wherein the plunger rod is transitionable from a pre-use position, in which at least a portion of the second end of the plunger rod extends along a portion of a barrel sidewall, to a ready-to-use position in which the plunger rod is aligned with the stopper. Upon proximal movement of the sleeve in a direction away from a first end of the barrel, the plunger rod is configured for lateral movement with respect to the cap into the ready-to-use position.

Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.

Abstract: A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. A piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user-actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft.

Abstract: A prefilled syringe is configured so that, in order that a liquid medicine injected and administered into the upper layer part of skin is prevented from leaking out of the living body, a pressing section can be held in a position reached when it has been completely pressed in. A prefilled syringe 1 is provided with: a double-ended needle 3 having a needlepoint 9 which can be inserted into a living body; a needle hub 4 for holding the double-ended needle 3; an outer tube 2; a pressing section 22; a liquid medicine storage section 6 for storing a liquid medicine M; a holding section 8; and a sealing body 23. The liquid medicine storage section 6 is disposed within a tube hole 2a of the outer tube 2. The pressing section 22 operates the liquid medicine storage section 6 so that the liquid medicine storage section 6 can move in the axial direction of the tube hole 2a of the outer tube 2.

Abstract: A method of making a system for transferring fluidic media may include placing a reservoir body in an aseptic environment; filling an interior volume of the reservoir body with fluidic media; placing a plunger head into the reservoir body, the plunger head adapted to be movable in an axial direction within the reservoir body; removing the reservoir body from the aseptic environment; and attaching a casing adjacent to at least a portion of the reservoir body with the reservoir body outside the aseptic environment, the casing configured to envelope at least a portion of a plunger arm operatively connected to the plunger head, the casing further configured to allow the plunger arm to move in the axial direction relative to the reservoir body and at least partially within the reservoir body.

Abstract: A replaceable needle assembly is provided for a retractable syringe comprising a barrel and a plunger, whereby the retractable needle can be replaced by a user without affecting the retraction mechanism. A mounting member is removably mountable to the barrel by way of a screw-thread connection and a needle mount is removably coupled to the mounting member. A needle is mounted to the needle mount. The barrel comprises a needle mount retainer that comprises a plurality of fingers that engage the retractable needle mount to prevent inadvertent retraction. The plunger comprises a collapsible seal which maximizes the efficiency of fluid delivery prior to the plunger engaging the retractable needle mount for retraction. An initially compressed spring decompresses to drive retraction of the plunger and the engaged needle mount. A lock formed between the plunger and barrel prevents further use of the plunger after retraction.

Abstract: A replaceable needle assembly is provided for a retractable, prefilled syringe comprising a barrel having a mounting member and a plunger, whereby the retractable needle can be replaced by a user without affecting the retraction mechanism. The replaceable needle assembly comprises a needle fitted to a retractable needle mount and a needle retainer. The needle mount is removably, screw-threadedly mountable to the mounting member of the barrel. The needle retainer comprises a plurality of fingers that releasably engage the retractable needle to thereby prevent inadvertent retraction of the retractable needle before engagement by the plunger. The plunger comprises a plunger seal comprising an outer member and an inner member that engages the needle for spring-driven retraction. At the end of retraction, a lock is formed between the plunger and barrel to prevent re-use of the syringe.

Abstract: A syringe includes a cylindrical container in which is arranged at least a first piston which delimits a storage volume. The syringe is provided with at least one yielding element having a first side that delimits the storage volume in a liquid tight fashion, and having a second side that is in communication with the surroundings of the syringe. This renders the syringe liquid tight even if the pressure of the substance in the storage volume increases. This may be used when sterilizing with heat or when freeze drying substance in the syringe. The syringe can include a first piston with a first piston rod and a second piston with a second piston rod. The two pistons then define two storage volumes which may be used for storage of freeze dried substance and a solvent for the freeze dried substance, respectively.

Abstract: A medicament delivery device has a housing for a medicament container and a drive unit for a stopper in the container to expel a dose of medicament, the drive unit having a plunger rod and a dual back-to-back force spring assembly connected to the plunger rod; and a lock and release mechanism connected to the drive unit that has a hold member, and a tubular actuation member linearly slidable in relation to the housing and connected to the rotator member. The hold member is attached to the housing and has a generally tubular lock tube through which the plunger rod extends and two half-cylindrical seats for the dual back-to-back force spring assembly. The lock tube has a resilient lock and release device to interact with both the plunger rod and the rotator member.