Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.
Type:
Grant
Filed:
July 1, 1991
Date of Patent:
October 13, 1992
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Richard A. DiPietro, Jan-I Tu, Noor Z. Turabi
Abstract: Layer transfer process for image production wherein predetermined areas of the surface of an image carrier (21) are prepared to accept a color layer, the image carrier (21) and a color carrier (22) of layer transfer material are brought into mutual contact under pressure, and the color carrier is removed from the image carrier, so that color remains on the predetermined areas of the image carrier. A high uniformity of colorant application can be achieved over the entire surface of the image carrier. The process is performed by an apparatus with at least one roll nip (31) formed by two hard rolls (11, 12), preferably with different diameters, in which the two rolls are mutually offset relative to the feed direction (30) of the image carrier (21).
Abstract: Partially stabilized cubic or tetragonal zirconia powder are provided which comprise aggregates of dense equiaxial primary particles, wherein said particles have an average diameter of less than about 150 nm and comprise zirconia and a homogeneously distributed stabilizer, as well as processes for their production employing flame combustion of homogeneous mixtures of ZrCl.sub.4 and stabilizer precursors.
Abstract: 2,2-Dihydrocarbyl-3-propiolactones are prepared by the thermolysis at 175.degree. C. to 350.degree. C. of low molecular weight (oligomeric) poly(3-hydroxy-2,2-dihydrocarbylpropionic acid) that contains carboxyl ends groups, in the presence of alkali metal, ammonium or phosphonium cations. The propiolactones may be polymerized to high molecular weight polymers.
Abstract: A C-MOS sense amplifier capable of detecting voltage differences between the signals applied to its inputs in correspondence with the clock signal transitions. The amplifier has a level converter, a sense circuit and a feedback block which are inactive in a first inactive phase of the clock signal, while in a second active phase, immediately after clock signal transition, the sense amplifier attains the operating point necessary to activate the level converter and the sense circuit. Hence a high positive feedback is started which switches the sense circuit. Finally, after the level transition of a delayed clock signal, the feedback signal generated by the feedback block reduces to zero the dissipation of the whole differential sense amplifier.
Type:
Grant
Filed:
December 19, 1990
Date of Patent:
October 13, 1992
Assignee:
Cselt - Centro Studi e Laboratori Telecomunicazioni S.p.A.
Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
Type:
Grant
Filed:
November 13, 1989
Date of Patent:
October 13, 1992
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
David J. Carini, John J. V. Duncia, Pancras C. B. Wong
Abstract: A waveguide for second order nonlinear wavelength conversion comprising a thin film embedded in an optically passive waveguiding medium wherein the film is nonlinear optically active and has periodic modifications of the nonlinear optical properties in the propagation direction, and said film thickness is less than 50% of the smallest effective transverse dimension of the waveguide, and said film width is greater than or equal to the largest transverse dimension of the waveguide, said waveguide is preferably surrounded by cladding media having lower refractice indices than the waveguide.
Abstract: A process for forming polytetramethylene ether glycol having a number average molecular weight of 600 to 2,200 by contacting tetrahydrofuran with 5 to 50 wt %, based on tetrahydrofuran, trifluoromethane sulfonic acid monohydrate and water at 20.degree. to 75.degree. C. is disclosed.
Abstract: Blends of nylon 6,6, nylon 6 or nylon 6,6/6 copolymer which contain a randomly copolymerized cationic dye modifier are formed by melt blending such copolymer with a polyamide having 8 to 22 carbon atoms per amide link to form a block copolymer composition which is resistant to staining with acid dyes under ambient temperature and pH conditions.
Abstract: Polymeric compositions endowed with high characterics of self-extinguishing o flame based on thermoplastic polymers or having elastomeric properties, especially olefin polymers and copolymers, comprising:a) from 91 to 40 parts by weight of a thermoplastic polymer or having elastomeric properties;b) from 6 to 33 parts by weight of one or more phosphates and/or phosphonates of ammonium or of an amine;c) from 3 to 27 parts by weight of one or more compounds derived from 2,4-diamino-6-hydroxy-1,3,5-triazine, having the general formula (I): ##STR1##
Type:
Grant
Filed:
September 9, 1991
Date of Patent:
October 6, 1992
Assignee:
Ministero Dell'Universita' E Della Ricerca Scientifica E Technologic
Abstract: A reactive oligoimide, which may serve as an adhesive for bonding at least one layer or film to another layer, preferably a flexible metallic layer to a flexible layer of a polyimide, in order to form a flexible multilayer metal-clad laminate.
Abstract: Novel angiotensin II receptor antagonists of the formula ##STR1## wherein X, X.sub.1, X.sub.2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein, are disclosed. These compounds are useful, for example, in the treatment of hypertension, congestive heart failure and cardiac hypertrophy.
Abstract: A mixture containing 6-aminocapronitrile is purified by reacting the tetrahydroazepine contained therein with a methylene compound, and then distilling the 6-aminocapronitrile from the resulting mixture.
Abstract: Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
Abstract: Photopolymerizable compositions in which the photoinitiator system contains a hexaarylbisimidazole and/or a p-dialkyaminophenyl carbonyl compound in combination with a borate anion coinitiator are disclosed.
Abstract: A process for preparing herbicidal sulfonylureas which comprises mixing a sulfonylisocyanate and a heterocyclic amine in the absence of a solvent.
Abstract: A signal representative of the total incident flux on each area element of a target plane is generated. Each area element corresponds to a portion of the object from which the flux emanates. Each total incident flux signal is corrected to eliminate therefrom the effects of flux incident on the corresponding area element due to scattering, thereby to generate a signal representative of the flux incident on that area element emanating only from the portion of the object corresponding to that area element. The total incident flux signal is corrected by weighting each total incident flux signal in accordance with a predetermined weighting factor W(x,y), and summing the weighted signal representative of the total flux incident on an area element with a weighted total incident flux signal from each of the other area elements.
Abstract: An improved process for preparing alkanoyloxyacetyloxybenzenesulfonate salts in which phenyl esters of alkanoyloxyacetic acids (alkanoyloxyacetyloxybenzenes) are sulfonated to yield novel alkanoyloxyacetyloxybenzenesulfonic acids which, on neutralization, yield the corresponding alkanoyloxyacetyloxybenzenesulfonate salts.
Type:
Grant
Filed:
March 25, 1991
Date of Patent:
October 6, 1992
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Bijan Amini, Donald J. Dumas, George C. Sonnichsen
Abstract: Disclosed are rigid fluorinated monomers, their preparation, and polymers derived therefrom based on two novel tricyclic xanthene core systems, 9,9-bis-(perfluoroalkyl)xanthene (I) and 9-phenyl-9-perfluoro-alkylxanthene (II). The monomers have utility in the preparation of advanced high-performance polymers, particularly polyimides.