Abstract: 7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula ##STR1## wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or ##STR2## wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is ##STR3## then Y cannot be O, and when Z is --CH.dbd.CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=; R is CO.sub.2 H, CO.sub.2 lower alkyl, CH.sub.2 OH, CO.sub.2 alkali metal, CONHSOR.sup.3 m CONHR.sup.3a or --CH.sub.2 -5-tetrazolyl, X is O, S or NH; and where R.sup.1, R.sup.2, R.sup.3 and R.sup.3a are as defined herein.
Type:
Grant
Filed:
October 10, 1991
Date of Patent:
October 6, 1992
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Raj N. Misra, Philip M. Sher, Philip D. Stein, Steven E. Hall, David Floyd, Joel C. Barrish
Abstract: A connector apparatus for receiving and ejecting a memory card which is connected to a electronic device, includes an ejection lever being able to slide on a surface of a housing plate for pulling out and disconnect the memory card from connecting pins by hooking at an edge of the memory card, and a rotating axis for enabling the ejection lever to swing on the surface of housing plate and holding the ejection lever rotatable through the housing plate by sliding contact within an internal surface of tubular projection of the lever.
Abstract: A process for producing a stable, bactericidal and fungicidal composition which consists essentially of bubbling air or oxygen into limonene, to produce an oxidized limonene having a rapid bactericidal activity as evidenced by the capability of killing at least 99.99% of the bacteria in a suitable culture medium inoculated with 10.sup.6 colony forming units of Staphylococcus aureus ATCC 25923 per ml.
Type:
Grant
Filed:
June 1, 1990
Date of Patent:
October 6, 1992
Assignee:
Doyle E. Chastain
Inventors:
Doyle E. Chastain, W. Eugene Sanders, Jr., Christine C. Sanders
Abstract: An aqueous fluorochemical finish composition for imparting antisoiling protection to textile fibers, e.g. nylon yarns, is composed of fluorochemical textile antisoilant, lubricant and a combination of cationic and nonionic surfactants.
Abstract: A thermoplastic mouthguard has a U-shaped base with top and bottom sides and upward inner lingual and outer labial walls forming a channel for the upper jaw teeth having posterior and anterior portions. Occlusal posterior pads are on the bottom side of the base along the posterior portions of the guard to space apart the anterior teeth of the lower jaw from the anterior portion of the bottom side of the U-shaped base and to lessen pressure and possible impact forces exerted at the temporomandibular joint. Occlusal impact chambers are located within the occlusal posterior pads for shock dissipation and absorption. Anteriorly directed ridges are located along the bottom of the impact surfaces of the occlusal posterior pads for custom fitting of the mouthguard and tending to move the lower jaw anteriorly when a force impact is imposed upon the lower jaw. An anterior impact brace is located along the anterior portion of the outer labial wall.
Abstract: This invention relates to a method and apparatus for determining the flatness or planarity of a surface and, specifically, to a method and apparatus for determining the flatness or planarity of a surface using a computerized optics technique.
Type:
Grant
Filed:
January 23, 1990
Date of Patent:
October 6, 1992
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Joseph A. Beni, Michael J. Merrill, Arun Prakash, John Taylor
Abstract: Novel molecular sieves are disclosed which are oxides of (a) an alkali metal, an alkaline earth metal and/or ammonium, (b) beryllium, cobalt and/or zinc, and (c) phosphorous, arsenic and/or vanadium, and optionally contain water. These zeolite-like materials, which contain little or no aluminum or silicon, can be made by a novel low temperature process. The molecular sieves are useful as ion exchange resins.
Abstract: A film comprising alternating layers of polyvinylidene chloride resin and a solvent barrier such as polyvinyl alcohol provides superior barrier properties. Barrier and mechanical properties are enhanced when formulation additives are present at customary levels only in the outermost layers.
Type:
Grant
Filed:
February 5, 1992
Date of Patent:
September 29, 1992
Assignee:
E. I. du Pont de Nemours and Company
Inventors:
Charles L. Beeson, Raymond T. Cole, Gedeon I. Deak, Harbeson H. Leidolf, Jr.
Abstract: A process and apparatus for the on-demand, low tension feeding of a filling member for weft insertion in a loom without substantial twist. The filling member is supplied without substantial twist at an average rate equal to the process speed take-up rate of the loom. The supplied filling member is advanced into a filling member accumulator from which the filling member is withdrawn by the loom. As the filling member is advanced into the accumulator, it is formed into serpentine folds. The supplying of the filling member is controlled in response to the filling member being taken up by the loom and a sufficient amount of the filling member is caused to accumulate in the accumulator to meet the high demand for the filling member when the loom accelerates to process speed operation.
Abstract: An enzyme-linked immunoassay for the determination of cyclosporin A levels in whole blood samples is provided based on the utilization of .beta.-D-galactosidase as an enzyme label and chlorophenol red-.beta.-D-galactopyranoside or resorufin-.beta.-D-galactopyranoside as a .beta.-D-galactosidase substrate.
Abstract: An improved method for the purification of monoclonal antibodies using Protein G, whereby the monoclonal antibodies are eluted from the Protein G at alkaline pH.
Abstract: A process for solubilizing membrane receptor proteins which includes exposing an outer membrane having the desired protein to an oxidizing agent, treating the membrane with a detergent and treating with an inhibitory material lowering agent. This method maintains the activity of the membrane proteins after solubilization.
Abstract: A transform digital optical processing system generates a transform signal of an image. Fourier or other well-known transforms may be employed. The transform signal may be generated in one of two ways: optically or electronically. In optical generation a two dimensional object is generated by modulating a beam of coherent light with an image of the object. A transform image of the modulated coherent light beam is formed, using an optical transform element. The optical transform is then stored in a two dimensional buffer. The transform signal may also be generated electronically by storing a digital video image of an object and generating a Fourier or other transform of the digital video image using vector processing chips or other commercially available digital transform generating computers. This digitally generated information may be analyzed and classified through a neural network type processor.
Type:
Grant
Filed:
March 19, 1990
Date of Patent:
September 29, 1992
Assignee:
E. I. Du Pont de Nemours and Company
Inventors:
Roeland M. T. Hekker, Izhak M. Livny, Gregory S. Mercurio
Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3, n, m and p have the meanings reported in the specification), their preparation and the compositions for pharmaceutical use containing them as active ingredient are described.The compounds of formula I have dopaminergic vasodilator activity and they may be used in pharmaceutical field.
Type:
Grant
Filed:
July 31, 1991
Date of Patent:
September 29, 1992
Assignee:
SIMES Societa Italiana Medicinali e Sintetici S.p.A.
Inventors:
Cesare Casagrande, Gabriele Norcini, Francesco Santangelo, Claudio Semeraro
Abstract: A yarn cutting apparatus comprising a cutter body, cutting means, and rigid stop means, wherein a line-to-surface contact is created between the cutting elements for cutting the yarn. The cutting means includes a slotted cutting element affixed to either the cutter body or a piston.
Abstract: The present invention relates to electrical connectors with a ground structure for impedance and cross talk control between signal carrying conductors.
Abstract: Selective hydrogenation of aliphatic dinitriles to aminonitriles is achieved under low pressure with high yield preferably using a Raney nickel or Raney colbalt-containing catalyst.
Abstract: A method to manufacture an articulated piston head wherein the two portions composing the head, i.e. the top portion and the pin boss portion, are formed separately from blanks of forged or cast chromium-molybdenum steel or a low alloy steel, subjected to preliminary machining operations, joined together by friction welding and then machined to final dimensions.
Type:
Grant
Filed:
April 16, 1991
Date of Patent:
September 29, 1992
Assignee:
Metal Leve S/A Industria E Comercio
Inventors:
Jose M. Martins Leites, Jose A. Cardosomendes, Andre Lippai, Paulo T. Dellanoce