Abstract: The present invention relates to a population of monodisperse magnetic nanoparticles with a diameter between 1 and 100 nm which are coated with a layer with hydrophilic end groups. Herein the layer with hydrophilic end groups comprises an inner layer of monosaturated and/or monounsaturated fatty acids bound to said nanoparticles and bound to said fatty acids, an outer layer of a phospholipid conjugated to a monomethoxy polyethyleneglycol (PEG) comprising a hydrophilic end group, or comprises a covalently bound hydrophilic layer bound to said nanoparticles.

Abstract: A multi-channel biopotential signal acquisition system is disclosed. In the system, a plurality of biopotential channels is corrected for common-mode interference. In one aspect, each biopotential channel includes an electrode for providing a biopotential input signal and an associated amplifier for amplifying the biopotential input signal and providing a biopotential output signal. The output signal is processed in a processor. Each biopotential output signal is passed to a common-mode feedback system, which determines an average common-mode signal and feeds that signal back to each of the amplifiers in each of the biopotential channels to enhance common-mode rejection ratio of the system.

Abstract: A method an system is disclosed for the detection and/or allocation of at least one point mutation in target DNA and/or RNA duplexes. The method comprises obtaining a functionalized surface which is coated with probe DNA and/or RNA whereto target DNA and/or RNA duplexes are attached, contacting said functionalized surface to an electrolytic solution having a neutral pH in a flow cell and measuring a first impedance value within said electrolytic solution, and then adding a chemical to the electrolytic solution which is able to achieve denaturation of the target DNA and/or RNA. The method further comprises measuring a second impedance value within the flow cell after completion of the denaturation of the DNA and/or RNA target, and then obtaining a value representative for the impact of the chemical on the impedance of the electrolytic solution.

Abstract: A system for assisting in spectrally characterizing or detecting a sample using radiation at a predetermined wavelength or in a predetermined wavelength range is disclosed. In one aspect, the system includes a substrate having a nanopore for excitation of plasmons. The nanopore provides a window through the substrate, wherein a smallest window opening of the window has an average length (L) and an average width (W) both being substantially smaller than 2 ?m. The nanopore supports highly confined surface plasmon polaritons and at specific wavelengths resonances are observed, when the conditions for a standing wave are fulfilled. This leads to strong field enhancements and enables single molecule spectroscopy.

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

Abstract: An instrumentation amplifier includes a first amplifier having one input connected to a first input of the instrumentation amplifier, a second amplifier having one input connected to a second input of the instrumentation amplifier, and a feedback network. The feedback network including an active filter having a first low pass filter characteristic with a first cut-off frequency in respect of differential mode signals at the first and second inputs of the instrumentation amplifier, and a second low pass filter characteristic with a second cut-off frequency in respect of common mode signals at the first and second inputs of the instrumentation amplifier. The disclosure also relates to a device for acquiring biopotential signals and a signal amplification method.

Abstract: A method for forming a noble metal layer by Plasma Enhanced Atomic Layer Deposition (PE-ALD) is disclosed. The method includes providing a substrate in a PE-ALD chamber, the substrate comprising a first region having an exposed first material and a second region having an exposed second material. The first material comprises a metal nitride or a nitridable metal, and the second material comprises a non-nitridable metal or silicon oxide. The method further includes depositing selectively by PE-ALD a noble metal layer on the second region and not on the first region, by repeatedly performing a deposition cycle including (a) supplying a noble metal precursor to the PE-ALD chamber and contacting the noble metal precursor with the substrate in the presence of a carrier gas followed by purging the noble metal precursor, and (b) exposing the substrate to plasma while supplying ammonia and the carrier gas into the PE-ALD chamber.

Abstract: A device (1) for sorting objects immersed in a flowing medium is described. The device comprises a holographic imaging unit comprising a plurality of holographic imaging elements (2), a fluid handling unit comprising a plurality of microfluidic channels (3) for conducting flowing medium along a corresponding holographic imaging element (2) and comprising a microfluidic switch (5) arranged downstream of an imaging region in the microfluidic channel for controllably directing each object in the flowing medium into a selected one of a plurality of outlets (6). The device also comprises a processing unit (7) adapted for real-time characterization of the holographic diffraction image obtained for each of the objects thereby taking into account at least one predetermined object type signature. The processing unit (7) furthermore is adapted for controlling the microfluidic switch (5) in response to the characterization.

Abstract: Described herein is a pinned photodiode pixel architecture having a p-type substrate that is independently biased with respect to a pixel area to provide an avalanche region between an n-type region and a p-type region formed on the substrate. Such a pinned photodiode pixel can be used in imaging sensors that are used in low light level conditions.

Abstract: The present disclosure relates to a method for forming a strained semiconductor structure. The method comprises providing a strain relaxed buffer layer, forming a sacrificial layer on the strain relaxed buffer layer, forming a shallow trench isolation structure through the sacrificial layer, removing at least a portion of an oxide layer on the sacrificial layer, etching through the sacrificial layer such that a portion of the strain relaxed buffer layer is exposed, forming the strained semiconductor structure on the exposed portion of the strain relaxed buffer layer.

Abstract: Provided herein is a method for producing hollow contact areas for insertion bonding, formed on a semiconductor substrate comprising a stack of one or more metallization layers on a surface of the substrate. Openings are etched in a dielectric layer by plasma etching, using a resist layer as a mask. The resist layer and plasma etch parameters are chosen to obtain openings with sloped sidewalls having a pre-defined slope, due to controlled formation of a polymer layer forming on the sidewalls of the resist hole and the hollow contact opening formed during etching. According to a preferred embodiment, metal deposited in the hollow contact areas and on top of the dielectric layer is planarized using chemical mechanical polishing, leading to mutually isolated contact areas. The disclosure is also related to components obtainable by the method and to a semiconductor package comprising such components.

Abstract: Disclosed are semiconductor devices and methods for manufacturing them. An example device may include a III-nitride stack having a front side surface and a back side surface. The III-nitride stack may be formed of at least a first layer and a second layer, between which a heterojunction may be formed, such that a two-dimensional electron gas layer is formed in the second layer. A source electrode, a drain electrode, and a gate electrode positioned between the source and drain electrodes may be formed on the front side surface, and an insulation layer may be formed over the electrodes on the front side surface. A carrier substrate may be attached to the insulation layer. An electrically conductive back plate may be formed on the back side surface. The back plate may directly face the source electrode and the gate electrode, but not the drain electrode.

Abstract: Micro-mirror arrays configured for use in a variable focal length lens are described herein. An example variable focal length lens comprises a micro-mirror array having a plurality of micro-mirror element arranged in at least a first section and a second section. Each micro-mirror element has a tilt axis and comprises, on each of two opposing sides of the tilt axis, (i) at least one actuation electrode, (ii) at least one measurement electrode, and (iii) at least one stopper. Additionally, each micro-mirror element in the first section has a first tilt axis range, and each micro-mirror element in the second section has a second tilt axis range, with the first tilt axis range being less than the second tilt axis range.

Abstract: A method is provided to test a modular integrated circuit (IC) comprising: testing a module-under-test (MUT) within the IC while causing a controlled toggle rate within a first neighbor module of the MUT; wherein the controlled toggle rate within the first neighbor module is selected so that toggling within the first neighbor module has substantially the same effect upon operation of the MUT that operation of the first neighbor module would have during actual normal functional operation of the first neighbor module.

Abstract: A system for the analysis of ECG signals is disclosed. The system may comprise (i) at least one readout channel, configured to receive an analog ECG signal acquired from at least one electrode attached to a body, and to extract an analog measured ECG signal and analog electrode-skin impedance signals; (ii) at least one ADC, configured to convert those extracted analog signals at the readout channel into digital signals; (iii) a digital adaptive filter unit, configured to calculate a digital motion artifact estimate based on said digital versions of the measured ECG signal and the electrode-skin impedance signals; (iv) at least one DAC, configured to convert said digital motion artifact estimate into an analog signal; and (v) a feedback loop for sending said analog motion artifact estimate signal back to the readout channel configured to deduct said analog motion artifact estimate signal from said analog measured ECG signal.

Abstract: A method is provided for bonding a first semiconductor substrate to a second semiconductor substrate using low temperature thermo-compression. The bonding method comprises the step of in-situ mechanically scrubbing the metal contact structure surfaces prior to thermo-compression bonding step, thereby planarizing the removing the oxides and/or contaminants from the metal contact structure surfaces.

Abstract: Disclosed are methods for forming hybrid metal-oxide-semiconductor field effect transistors (MOSFETs) and the hybrid MOSFETS thus obtained. In one embodiment, a method is disclosed that includes providing a first substrate comprising a first region and a second region, providing a second substrate comprising a second semiconductor layer and an insulating layer overlaying the second semiconductor layer, and direct substrate bonding the second substrate to the first substrate, thereby contacting the first region and the second region with the insulating layer. The method further includes selectively removing the second semiconductor layer and the insulating layer in the first region, thereby exposing the first semiconductor layer in the first region, forming a first gate stack of a first MOSFET on the exposed first semiconductor layer in the first region, and forming a second gate stack of a second MOSFET on the second semiconductor layer in the second region.

Abstract: A photonic integrated device comprises a waveguide embedded in a photonic substrate. The waveguide has a waveguide radiation exit surface and the waveguide is optically connected to a two dimensional grating. The photonic integrated device also comprises a two dimensional grating having a plurality of curved elongate scattering elements. The two dimensional grating is adapted for diffracting radiation received from the waveguide toward a direction out of the photonic substrate and the curved elongate scattering elements are oriented with respect to the waveguide such that, for points of the scattering elements which can be irradiated by radiations stemming from the waveguide, normal lines to at least the curved elongate scattering element closest to the waveguide radiation exit surface do not substantially intersect with the waveguide radiation exit surface of the waveguide.

Abstract: A solid-state battery cell includes an anode, a cathode, and a solid electrolyte matrix. At least the anode or the cathode may include an active electrode material having pores. Further, an inner surface of the pores may be coated with a first surface-ion diffusion enhancement coating. The solid electrolyte matrix may further include an electrically insulating matrix for a solid electrolyte. The electrically insulating matrix may have pores or passages and an inner surface of the pores or the passages may be coated with a second surface-ion diffusion enhancement coating.

Abstract: The present disclosure relates to a method for reducing second order intermodulation distortion in a harmonic rejection mixer arranged for down-converting a radio frequency signal to an in-phase and a quadrature baseband signal. The method includes adjusting an output current of a first mixer, to reduce the second order intermodulation distortion in the quadrature baseband signal to a first value, and adjusting an output current of a second mixer, to reduce the second order intermodulation distortion in the in-phase baseband signal to a second value.