Patents Assigned to SANDOZ
  • Method for degreasing natural skins, hides and pelts
    Patent number: 4572721
    Abstract: Skins, hides and pelts are effectively degreased under mild conditions prior to tanning, in the presence of an organic primary, secondary or tertiary amine having surface-active properties and containing at least one lipophilic residue and at least one ethylene oxide unit, optionally in admixture with a non-ionic emulsifier.
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: February 25, 1986
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
    Patent number: 4571428
    Abstract: 6-Substituted-4-hydroxy-tetrahydropyran-2-ones, useful as anti-atherosclerotic agents, are obtainable by the process of the invention. The 6-substituents have a phenyl, naphthyl, tetrahydronaphthyl or indolyl nucleus bound through an ethenyl unit. The invention includes novel intermediates.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: February 18, 1986
    Assignee: Sandoz, Inc.
    Inventor: Prasad K. Kapa
  • Use of certain esters as pH regulators in textile finishing processes
    Patent number: 4568351
    Abstract: A textile finishing process in which there is employed, as a pH regulator, a compound or a mixture of compounds of formula I ##STR1## in which p is from 1 to 20,R is hydrogen, C.sub.1-3 alkyl or C.sub.1-3 alkyl substituted by hydroxyR' has independently one of the significances given for R or is --CO--R andA is --CH.sub.2 CH.sub.2 --; --CH.sub.2 --CH.sub.2 --CH.sub.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: February 4, 1986
    Assignee: Sandoz Ltd.
    Inventors: Jose M. Palleiro Cardona, Karl-Heinz Weible
  • Alkali treatment of cellulosic fiber goods
    Patent number: 4568349
    Abstract: The invention relates to a process for alkali-dry treating cellulosic fibre goods comprising the steps of(a) treating the goods with an aqueous caustic soda solution of 18.degree.-26.degree. Baume, followed by(b) drying the treated goods under tension without an intermediate rinsing or neutralization step.The aqueous caustic soda solution used in step (a) may further contain a lubricant and wetting agents.
    Type: Grant
    Filed: August 16, 1982
    Date of Patent: February 4, 1986
    Assignee: Sandoz Ltd.
    Inventor: Angelo Rizzardi
  • Acylaminophenol derivatives
    Patent number: 4567192
    Abstract: Compounds of formula I ##STR1## wherein n=1 to 5 possessing analgesic activity with reduced hepatoxicity as compared with paracetamol.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: January 28, 1986
    Assignee: Sandoz Ltd.
    Inventors: Laszlo Revesz, Trevor J. Petcher
  • Benzoxadiazoles and benzothiadiazoles
    Patent number: 4567271
    Abstract: Compounds of formula I, ##STR1## wherein X is oxygen or sulphur, and R.sub.1 -R.sub.6 are various substituents. The compounds are useful for treating coronary insufficiency, intermittent claudication, cerebrovascular insults, spasms in muscles and hypertension.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: January 28, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • Pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline derivatives
    Patent number: 4565818
    Abstract: A 6- and/or 7-oxy-trans-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline in which the 3-position is substituted by an optionally amidated carboxy group, an optionally etherified hydroxymethyl group, a cyanomethyl group, an alkyl- or aryl-thiomethyl group or a sulfamoylamino or carbamoylamino group, or a physiologically-hydrolysable and -acceptable ester thereof. The subject compounds are useful as pharmaceuticals, in particular as prolactin secretion inhibitors, dopaminergic agents ad dopamine receptor stimulating agents.
    Type: Grant
    Filed: October 14, 1982
    Date of Patent: January 21, 1986
    Assignee: Sandoz Ltd.
    Inventors: Rene Nordmann, Trevor J. Petcher
  • Piperazine derivatives and pharmaceutical composition containing them
    Patent number: 4565816
    Abstract: Piperazine derivatives or pharmaceutically acceptable acid addition salts thereof are useful as neuroleptic, anti-hypertensive or bradycardic agents.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: January 21, 1986
    Assignee: Sandoz Ltd.
    Inventor: Peter Neumann
  • One-bath method for producing tone-in-tone dyeings on sueded wool- or fur-bearing skins
    Patent number: 4560386
    Abstract: Disclosed is a method for dyeing sueded wool- or fur-bearing skins tone-in-tone in a single bath and in one step. The dyeing is carried out with reactive dyestuffs bearing at least one reactive group selected from acryloylimino, halogenoacryloylimino and .beta.-halogenopropionylimino, in the presence of non-ionic or anionically modified polyalkoxylated surfactants.
    Type: Grant
    Filed: March 16, 1984
    Date of Patent: December 24, 1985
    Assignee: Sandoz Ltd.
    Inventors: Tony A. Hopkins, Rudolf Seitz
  • Method for improving the fastness of dyeings and optical brightenings with amine, cyanamide derivative and epihalohydrin condensate
    Patent number: 4559058
    Abstract: A precondensate obtained by reacting(A) the product of reacting a mono- or polyfunctional primary or secondary amine with cyanamide, dicyandiamide, guanidine or biguanidine and(B) an epihalohydrin is obtained in the form of a stable aqueous dispersion by acidifying the reaction product, optionally in the presence of a water-soluble polymer. The product is useful as an after-treatment agent to improve the fastness of dyeings on cotton, wool or silk.
    Type: Grant
    Filed: June 28, 1984
    Date of Patent: December 17, 1985
    Assignee: Sandoz Ltd.
    Inventors: Brian Bennett, Donald K. Clough
  • Solutions of U.V. absorbers useful for improving the light fastness of dyeings on polyester
    Patent number: 4557730
    Abstract: The invention provides a solution of one or more U.V. absorbers selected from resorcinol monobenzoate, phenyl salicylate and a benzophenone; and an emulsifier in an organic solvent system.The solutions of the invention are useful for providing level dyeings of polyester material particularly for use in the automotive industry.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: December 10, 1985
    Assignee: Sandoz Ltd.
    Inventors: Brian Bennett, Donald K. Clough
  • Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
    Patent number: 4554351
    Abstract: A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.
    Type: Grant
    Filed: May 5, 1983
    Date of Patent: November 19, 1985
    Assignee: Sandoz Ltd.
    Inventor: Roland Wenger
  • Processes for the preparation of liposome drug delivery systems
    Patent number: 4551288
    Abstract: Process and apparatus for the production of medicament containing liposomes, comprising an aliphatic lipid-sterol-water lamellae, wherein a clear, mixed micellar medicament-detergent-aliphatic lipid-sterol sample is applied to a gel filtration column. The column effluent is continuously monitored to detect the liposome fraction eluted, which is collected. The free medicament, detergent, lipid and/or sterol may be recirculated back to the column.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: November 5, 1985
    Assignee: Sandoz, Inc.
    Inventor: Lawrence A. Kelly
  • Metal-free disazo compounds containing at least two basic water-solubilizing groups and having a 1-phenylpyrazole middle component radical and a 6-hydroxyprid-2-one terminal coupling component
    Patent number: 4550158
    Abstract: Metal-free azo compounds of the formula ##STR1## wherein Ra is an aromatic group or an active methylene coupling component radical as defined in the specification,R.sub.t is an arylazo group or a group of the formula -Y-Z,whereinY is a direct bond or a bridging radical, andZ is a basic amino or quaternary ammonium group, ##STR2## wherein each of the variables is as defined above or below, X is a direct bond or a bridging radical,x is hydrogen, hydroxy C.sub.1-4 alkyl, C.sub.1-4 alkoxy, amino or carboxy,ring B is further unsubstituted or further substituted,d is 0, 1 or 2, andn is 0 or 1,with the provisos that (i) the compounds contain an average of at least 1.3 basic water-solubilizing groups, and (ii) the compounds are free of sulfo groups,and 1:1 and 1:2 metal complexes thereof,which metal-free compounds and metal complexes are useful as dyes for leather and paper.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 29, 1985
    Assignee: Sandoz Ltd.
    Inventors: Paul Doswald, Emil Moriconi, Helmut Moser, Horst Schmid
  • Process for the preparation of condensed triazoles
    Patent number: 4549026
    Abstract: A process for the preparation of condensed triazoles of formula I ##STR1## in which R together with the triazole group form an aromatic group R.sub.1 is hydrogen or a hydrocarbon groupthe process comprisingreacting in a medium containing an organic phase a compound of formula II ##STR2## with a nitrite and an acid. The reaction is preferably carried out at a raised temperature.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: October 22, 1985
    Assignee: Sandoz Ltd.
    Inventors: Michel Deur, Istvan Toth
  • Method for determining the compatibility of a direct or reactive dyestuff with a polybasic amino compound
    Patent number: 4548902
    Abstract: Dyeings on cellulose with direct or reactive dyestuffs are given improved wet fastness properties by aftertreatment with a reaction product or mixture of a polybasic amino compound (A) with an N-methylol compound (B) or with formaldehyde or a formaldehyde donor and optionally a crosslinking catalyst (C). Particular direct or reactive dyestuffs and polybasic amino compounds are determined to be suitable in the dyeing and aftertreatment when the dyestuff and the polybasic amino compound (A) are such that when mixed together in aqueous solution they give a precipitate which, after washing and drying does not redissolve in aqueous alkali at pH.gtoreq.12 at room temperature.
    Type: Grant
    Filed: June 1, 1983
    Date of Patent: October 22, 1985
    Assignee: Sandoz Ltd.
    Inventors: Rolf Hasler, Francis Palacin
  • Method for marking defects in leather
    Patent number: 4548609
    Abstract: Disclosed is a method for marking mineral tanned leather by treating the unfinished leather with an anionic aqueous dispersion of a fluorescent pigment. The marked leather can then be sorted by exposure to UV-radiation.
    Type: Grant
    Filed: January 12, 1984
    Date of Patent: October 22, 1985
    Assignee: Sandoz Ltd.
    Inventor: Alfred Schone
  • Ergot peptide derivatives, their preparation and pharmaceutical compositions containing them
    Patent number: 4547500
    Abstract: A 2-methyl-8 (R) or (S) ergot peptide alkaloid in free base form or in pharmaceutically acceptable acid addition salt form is a useful anti-Parkinson agent, prolactin secretion inhibitor, anti-depressant, vigilance-increasing agent, and anti-migraine agent.
    Type: Grant
    Filed: May 10, 1983
    Date of Patent: October 15, 1985
    Assignee: Sandoz Ltd.
    Inventors: Georg Bolliger, Peter Stutz
  • 1,4-Di-[2'-(2",4"-dichlorophenylazo)-3'-oxobutyramido]-2-methoxybenzene
    Patent number: 4544736
    Abstract: The compound of the formula ##STR1## exists in an .alpha.-modification and a .beta.-modification, the latter being obtained by treatment of the .alpha.-form with a boiling organic solvent, each of which, but especially the .beta.-modification, is useful as a pigment for the mass pigmentation of synthetic plastics and resins, free from or containing a solvent (e.g., viscose, cellulose acetate, polyethylene, polystyrene, polyvinyl chloride, synthetic leathers and synthetic rubbers), surface coatings (e.g., oil- and water-based paints), lacquers and inks and for pigment printing, textile coating and pigmenting paper in the mass.
    Type: Grant
    Filed: May 26, 1983
    Date of Patent: October 1, 1985
    Assignee: Sandoz Ltd.
    Inventor: Bansi L. Kaul
  • Indolamine derivatives as anti-fertility agents
    Patent number: 4544663
    Abstract: This disclosure relates to the aspermatogenesis activity of(a) compounds of the formula: ##STR1## where m is an integer from 1 to 4X represents hydrogen or --OHR represents Ar, ##STR2## Ar represents ##STR3## R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, R.sub.2 and R.sub.3 each, independently, represent lower alkyl, orR.sub.2 and R.sub.3 together with N represent ##STR4## wherein n is 1, 2 or 3,R.sub.4 represents hydrogen or lower alkyl, andR.sub.5 represents hydrogen or lower alkyl, unsubstituted phenyl or phenyl mono- or di-substituted with fluoro, chloro, lower alkyl or lower alkoxy, or(b) compounds of the formula: ##STR5## where R' is Ar or ##STR6## Ar, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above, or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: October 1, 1985
    Assignee: Sandoz, Inc.
    Inventors: Robert E. Manning, Jeffrey Nadelson