Abstract: An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.
Abstract: The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.
Type:
Grant
Filed:
December 27, 2013
Date of Patent:
December 25, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Hans Stettler, Wim Teughels, Marc Quirynen, Nico Boon
Abstract: A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent which reduces blood glutamate levels and enhances brain to blood glutamate efflux to thereby treat the cancer of the central nervous system in the subject.
Abstract: Formulations for oral care products that incorporate coconut oil for effectively removing bacteria from the mouth and methods for making these products are disclosed herein. A preferred mouth rinse contains alkaline water, coconut flavor oil extract, sodium lauryl sarcosinate, zinc chloride, 30% xylitol solution, glycerin, aloe barbadensis leaf juice, and optionally, sodium benzoate, de-ionized water, and mint flavor extract. A preferred toothpaste contains alkaline water, coconut oil, hydrated sylica sident 9, hydrated silica sident 22s, glycerin, xylitol, Irish moss, sodium coco sulphate, aloe babadensis leaf juice, titanium dioxide, and flavor. The percentage of the coconut oil content in the preferred products is in the range of 20%-80%, but most preferably 40%-60%.
Abstract: The present invention provides an oral composition comprising: (a) from 1 wt % to 60 wt % of a calcium-containing abrasive; (b) a calcium-catching phosphate source in an amount sufficient to provide at least 100 mM of phosphate ions, PO43?; (c) no more than 20 wt % of a humectant; and (d) at least 5 wt % of water; wherein the oral composition has a pH from 8 to 11.
Abstract: A composition for mixing with water for use as an oral rinse, comprising monobasic sodium phosphate, dibasic sodium phosphate, sodium chloride, and calcium chloride.
Abstract: The present invention is directed to an oral composition containing a gel network phase comprising: (i) one or more fatty amphiphiles, (ii) one or more surfactants, and (iii) one or more solvents; and an oral carrier phase. In certain embodiments, the gel network is used to structure the oral composition. The present invention is also directed to a method of forming an oral composition containing a gel network.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
November 20, 2018
Assignee:
THE PROCTER & GAMBLE COMPANY
Inventors:
George Endel Deckner, Arif Ali Baig, Michael Jude LeBlanc
Abstract: A method for repairing dentition, including milling beta tricalcium phosphate with sufficiently high energy to substantially distressed its lattice structure, mechanochemically chelating an edible acid thereto to yield functionalized calcium phosphate moieties, and incorporating the functionalized calcium phosphate moieties into an edible material to yield a calcium phosphate delivery system. The calcium phosphate delivery system is introduced into an oral environment and dentition is repaired. The functionalized calcium phosphate moiety is characterized by weakly bonded fumaric acid at least partially wrapped around distressed calcium phosphate particles, and dentition repair occurs at a dentition depth of at least 10 microns below the surface.
Abstract: Disclosed are oral care compositions having reduced tooth staining propensity and comprising in a pharmaceutically acceptable carrier, a cationic antimicrobial agent and an anti-stain agent comprising one or more materials from each of at least two of the following chemical groups: Group 1. anionic agents, Group 2. aldehydes, ketones, and other reactive carbonyl compounds and Group 3. nonionic ethoxylated surfactants. Examples of cationic antimicrobial agent include quaternary ammonium compounds such as cetylpyridinium chloride, cetyl pyridinium fluoride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride and domiphen bromide; chlorhexidine; and metal ion sources to supply metal ions such as stannous, zinc or copper.
Abstract: Described herein, are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt, e.g., sodium tripolyphosphate (Na5P3O10), and external personal care compositions comprising the complexes, and uses thereof.
Type:
Grant
Filed:
December 28, 2016
Date of Patent:
November 13, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Shiri Nawrocki, Viktor Dubovoy, Long Pan
Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide. Methods of making and using the compositions are also provided.
Type:
Grant
Filed:
December 19, 2012
Date of Patent:
October 23, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Long Pan, Shaotang Yuan, Shira Pilch, James G. Masters, Zhiqiang Liu
Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.
Type:
Grant
Filed:
July 31, 2015
Date of Patent:
October 16, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Aarti Rege, David Suriano, Richard Sullivan
Abstract: The present invention relates to a sustained release medical composition comprising an active pharmaceutical ingredient and a geopolymeric binder. Preferably the active pharmaceutical ingredient is combined with the geopolymeric binder during the formation of that binder.
Abstract: Compositions for stimulating hydrocarbon production from a subterranean formation are generally disclosed. In some embodiments, such compositions include olefinic ester compounds, such as alkyl esters of C10-18 unsaturated fatty acids. In some embodiments, the olefinic ester compounds are derived from a natural oil or a natural oil derivative, for example, by catalytic olefin metathesis. Uses of such compounds, such as in oil- and gas-production methods are also generally disclosed.
Abstract: The present invention provides nutrient zinc and copper fortifying composition for food products. More particularly the present invention provides zinc and copper fortifying composition comprising zinc lactate gluconate, copper ion source, and class II preservative. The invention further provides a hydration supplement and a fortified water beverage to supplement the deficiencies of zinc in humans.
Type:
Grant
Filed:
September 23, 2011
Date of Patent:
September 25, 2018
Assignee:
Tata Global Beverages Ltd.
Inventors:
Pradeep Poddar, Henry Hidell, C. E. Agro, Michael Collette
Abstract: To provide acidic electrolyzed water having disinfecting power for a long period of time (for example, six months or more), and a production method for this acidic electrolyzed water. The acidic electrolyzed water has an effective chlorine concentration equal to or greater than 15 ppm, and contains an acid salt of an inorganic acid.
Abstract: An oral composition is provided comprising at least 0.5% by weight of the composition of pyrophosphate in an orally acceptable carrier, wherein the pyrophosphate is provided by a mixture of disodium pyrophosphate and tetrapotassium pyrophosphate in a ratio from disodium pyrophosphate to tetrapotassium pyrophosphate in the range of from 1:0.4 to 1:1.2 and wherein the pH value of the composition is in the range of from 6.0 to 8.0. The oral composition can be used for prevention and control of tartar and/or calculus formation.
Type:
Grant
Filed:
November 4, 2015
Date of Patent:
September 25, 2018
Assignee:
The Procter & Gamble Company
Inventors:
Golam Faruque Khan, William Michael Glandorf
Abstract: An oral composition is provided comprising at least 0.5% by weight of the composition of pyrophosphate in an orally acceptable carrier, wherein the pyrophosphate is provided by a mixture of disodium pyrophosphate and tetrasodium pyrophosphate in a ratio from disodium pyrophosphate to tetrasodium pyrophosphate in the range of from 1:0.4 to 1:1.2 and wherein the pH value of the composition is in the range of from 6.0 to 8.0. The oral composition can be used for prevention and control of tartar and/or calculus formation.
Type:
Grant
Filed:
November 4, 2015
Date of Patent:
September 25, 2018
Assignee:
The Procter & Gamble Company
Inventors:
Golam Faruque Khan, William Michael Glandorf
Abstract: Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
August 3, 2016
Date of Patent:
September 11, 2018
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
Inventors:
Marvin Cohen, Susanne Cohen, Robert G. Flynn
Abstract: Described herein are compositions comprising an active compound from an extract of magnolia, or a derivative thereof; and a non-surfactant electrolyte in an amount effective to stabilize the composition, and methods of making and using the same.
Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
Type:
Grant
Filed:
June 9, 2015
Date of Patent:
September 4, 2018
Assignee:
BIOMATRICA, INC.
Inventors:
Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
Abstract: This invention relates to oral care compositions comprising arginine, zinc citrate and zinc oxide, and an orally acceptable carrier, as well as to methods of using and of making these compositions.
Abstract: A chewing gum for highly efficient and quick plaque and tartar removal and inhibition including pure ascorbic acid crystals and/or granulars (vitamin C) and an enamel repairing composition such as a blend of hydroxyapatite crystals and sodium fluoride. The chewing gum can contain at least 20% of ascorbic acid without compromising the integrity of tooth enamel because hydroxyapatite will repair any damage to the enamel.
Abstract: Surface staining can be minimized or eliminated by providing an oral care composition comprising a first film comprising a pigment; and optionally a second film; wherein the first film has a dissolution rate in aqueous media that is inversely proportional to its thickness, wherein the first film is in the form of a particle.
Type:
Grant
Filed:
December 10, 2014
Date of Patent:
August 14, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Gregory Szewczyk, Neeta A. Patel, Suzanne Jogun, Shashank Potnis
Abstract: Compounds of formula (I) are as defined in the claims, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.
Type:
Grant
Filed:
February 13, 2015
Date of Patent:
August 7, 2018
Assignee:
SYNGENTA PARTICIPATIONS AG
Inventors:
Ramya Rajan, Daniel Stierli, Renaud Beaudegnies
Abstract: The present invention provides a tooth whitening oral care composition comprising: (i) a dye having a blue to blue-violet color with a hue angle in the CIELAB system ranging from 200 to 320 degrees; (ii) core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core is etched with metal silicate; (iii) an orally acceptable carrier vehicle comprising a non-aqueous solvent; and wherein the composition comprises water in an amount of from 3 weight % to 30 weight %.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
July 31, 2018
Assignee:
COLGATE-PALMOLIVE COMPANY
Inventors:
Venda Maloney, Suman Chopra, Hallena Strotman, Guisheng Pan
Abstract: The present invention relates to a composition, for inhibiting dental erosion, and the use thereof. The composition comprises an aqueous solution of hydrofluoric acid, in which the concentration of hydrofluoric acid is 0.05%-2.00% and the pH is between 2.5 and 4.5.
Abstract: A method of determining the viability of a gum for use in making a product has been achieved by (a) mixing a sample of the gum in a solvent comprising one or more hydroxy moiety containing solvent compound to form a solution with the gum; (b) measuring the viscosity of the solution and comparing against a predetermined target viscosity for a product; and (c) comparing the viscosity of the solution and the predetermined target viscosity and discarding gum which is outside the predetermined target viscosity; and (d) using the gum which has a viscosity within the predetermined target to prepare a product; wherein another hydroxy moiety containing solvent is used if water is used as a solvent. Also described are compositions comprising the gum and solvent comprising one or more hydroxy moiety.
Type:
Grant
Filed:
December 5, 2014
Date of Patent:
July 10, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Enzo T. Utima, Erico V. Prat, Shashank Vishwanath Potnis, Shridhara M. Kamath, Amit U. Sirdesai, Rupali J. Madhavi, Santosh V. Vartak, Rolando Plata
Abstract: A hydrocolloid or aqueous solution comprising a poly alpha-1,3-glucan ether compound is disclosed having a viscosity of at least about 10 centipoise (cPs). The poly alpha-1,3-glucan ether compound in these compositions has a degree of substitution of about 0.05 to about 3.0. Also disclosed is a method for increasing the viscosity of a hydrocolloid or aqueous composition using a poly alpha-1,3-glucan ether compound.
Type:
Grant
Filed:
December 15, 2014
Date of Patent:
June 26, 2018
Assignee:
E I DU PONT DE NEMOURS AND COMPANY
Inventors:
Rahul B. Kasat, Jayme L. Paullin, Andrea M. Perticone, T. Joseph Dennes, Rakesh Nambiar, Michael W. Cobb
Abstract: Provided is a liquid mouthwash that is capable of maintaining a bactericidal effect over a long period, and uses electrolyzed water that inhibits metal corrosion. The liquid mouthwash contains electrolyzed water having a positive oxidation-reduction potential, a menthol, an anionic surfactant, and a water-soluble organic solvent, and has a pH of 6 to 8. The electrolyzed water, and the menthol or one or more anionic surfactants are accommodated without coming into contact with each other, and are preferably used in a mixed state at the time of use.
Abstract: The present invention relates to oral compositions for identifying plaque comprising a dental disclosing agent composition for revealing the presence of dental plaque in a person's mouth. The composition comprises a natural colorant derived from annatto seed and a colorant that stains plaque and when added to annatto seed extract results in a color having a wave length of 500 nm to 580 nm and.
Abstract: A method of improving the cosmetic appearance of human teeth comprising the step of contacting the teeth with a whitening powder composition after ingesting a chromogenic, tannin-containing food or beverage and thereby reducing staining of the teeth caused by tannins and/or chromogens. The tooth-whitening tablet is comprised of (i) at least one abrasive powder; (ii) at least one buffering powder; (iii) a complexing agent; and, optionally, (iv) an anti-cavity sweetener.
Abstract: Disclosed herein are mouthwashes comprising a complex of a zinc ion source acid. Methods of making and using the compositions are also provided.
Type:
Grant
Filed:
December 19, 2012
Date of Patent:
May 29, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Long Pan, Shaotang Yuan, Shira Pilch, James G. Masters, Zhiqiang Liu
Abstract: The present invention describes novel and improved dosage forms containing fluticasone propionate for the treatment of conditions associated with inflammation of the esophagus.
Abstract: The present invention provides an oral care composition comprising, based on the total weight of the composition: (a) 15 to 24 weight % calcium carbonate; (b) 0.9 to 2.5 weight % cellulose ether thickening agent; (c) 7 to 10 weight % thickening silica; and (d) at least 40 weight % water.
Type:
Grant
Filed:
December 16, 2013
Date of Patent:
May 22, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Robert D'Ambrogio, Andrei Potanin, Guisheng Pan, Nora Lin
Abstract: Provided are oral care compositions comprising one or more polyol solvents having a total Hansen Solubility Parameter (HSP) of from about 23 to 28, one or more non-anionic bioactive agents, and an aqueous phase, wherein the oral care composition is essentially free of alkyl sulfate surfactants, as well as method of using such compositions in the oral cavity.
Type:
Grant
Filed:
October 20, 2016
Date of Patent:
May 22, 2018
Assignee:
Johnson & Johnson Consumer Inc.
Inventors:
Michael Fevola, Stephanie Kirby, Joseph LiBrizzi, Saroja Narasimhan, Frank Sun, Daniel Queiroz
Abstract: A dentition strengthening delivery system having separate phosphate and calcium salts derived from separate source in a semisolid comestible matrix. The ratio of phosphate to calcium is at least 1:1, and the phosphate concentration is between about 10 ppm to about 10,000 ppm.
Abstract: Provided is an oral care composition comprising a phosphate/acrylate co-polymer, a tartar control agent, and an orally acceptable carrier and methods of using the same.
Type:
Grant
Filed:
December 20, 2013
Date of Patent:
May 22, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Michael Prencipe, Suzanne Jogun, Xiang Chen
Abstract: A method of operating of a gas turbine engine to inhibit vanadic corrosion of the gas turbine engine is provided. The gas turbine engine burns a vanadium-contaminated fuel and includes a component configured to be in contact with combustion gases. The method includes introducing into a combustion system of the gas turbine engine a first oxide and at least one second oxide. The first oxide includes magnesium oxide, and the at least one second oxide includes at least one of aluminum oxide, iron (III) oxide, titanium dioxide, and silicon dioxide. The method further includes cleaning at least a portion of the component using a cleaning agent containing a liquid vector and at least one descaling material that is suspended in the liquid vector. The at least one descaling material is an inorganic material.
Type:
Grant
Filed:
April 20, 2015
Date of Patent:
May 22, 2018
Assignee:
GE Energy Products France SNC
Inventors:
Dmitry Sokolov, Matthieu Paul Frederic Vierling, Christophe Fabrice Verdy, Michel Marie Raymond Moliere
Abstract: A dual-phase mouthwash composition for whitening teeth is disclosed. The dual-phase mouthwash composition includes an orally acceptable vehicle having a hydrophilic phase and a hydrophobic phase, a blue dye and/or blue pigment having a blue to blue-violet color with a hue angle in the CIELAB system from about 200 to about 320 degrees, and a zinc salt.
Type:
Grant
Filed:
October 27, 2016
Date of Patent:
May 22, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Eric Simon, Venda Porter-Maloney, Vyoma Patel
Abstract: The present application provides an oral care composition comprising: a) one or more omega fatty acids; and one or more of the following: b) one or more emulsifying agents; c) one or more protease enzymes; d) one or more soluble calcium phosphate remineralizing agents; e) one or more amino acids.
Abstract: A child hygiene training device for providing inert hygiene items for use by a child to form good hygiene habits at an early age includes a plurality of hygiene tools. Each of the hygiene tools is configured for use by a child to perform a respective hygienic task. The plurality of hygiene tools includes a mock deodorant comprising inert ingredients configured for safe application to the child while mimicking application of a genuine deodorant.
Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions. Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.
Type:
Grant
Filed:
January 6, 2016
Date of Patent:
May 15, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
James R. Brown, Linh Fruge, Tao Xu, Michael Prencipe
Abstract: Compositions and methods for reducing oral sensitivity, increasing the systemic health of a mammal, occluding a dentinal tubule within a mammalian tooth, and/or depositing a precipitate on the surface of a mammalian tooth are provided, said compositions comprising theobromine (3,7-dimethylxanthine, the principal alkaloid in Theobroma cacao).
Abstract: Composite body comprises nanofibrillar cellulose (NFC) together with abrasive particles (AP). The nanofibrillar cellulose forms a 3-dimensional connecting network for the abrasive particles (AP). The abrasive particles have a hardness above 7 on Mohs scale. The composite body is used for grinding, polishing or cutting.
Type:
Grant
Filed:
September 5, 2014
Date of Patent:
May 8, 2018
Assignees:
UPM-KYMMENE CORPORATION, KWH MIRKA LTD
Inventors:
Hans Hede, Christer Kavander, Mats Sundell, Antti Laukkanen
Abstract: The present invention provides an oral care composition comprising, by total weight of the composition: (a) 15 to 35 weight % calcium carbonate; (b) 0.5 to 2 weight % cellulose ether thickening agent; (c) 1 to 6 weight % clay thickening agent; and (d) at least 35 weight % water; wherein, when the composition comprises less than 28 weight % calcium carbonate and less than 4 weight % clay thickening agent, the cellulose ether thickening agent is present in an amount of greater than 1 weight %.
Type:
Grant
Filed:
December 16, 2013
Date of Patent:
April 24, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Robert D'Ambrogio, Andrei Potanin, Guisheng Pan, Nora Lin
Abstract: A method of reducing the number of microorganisms entering the nose and proliferating in the nasal cavity including application of a solution of an antimicrobial, antiviral and antifungal composition to the anterior vestibular region of the nares. The antimicrobial, antiviral and antifungal solution includes ethyl alcohol as an active ingredient. Various embodiments may also include one or more of the following additional ingredients: orange oil; coconut oil; soy oil; emu oil; grapefruit seed extract; glycine soja; simmondsia chinensis (Jojoba); lauric acid; chlorhexidine gluconate; ginger oil; lavender oil; peppermint oil; spearmint oil; aloe oil; and a preservative, such as benzalkonium chloride and vitamin E.
Abstract: The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.
Type:
Grant
Filed:
April 1, 2010
Date of Patent:
April 10, 2018
Assignee:
Colgate-Palmolive Company
Inventors:
Suman K. Chopra, Lynette Zaidel, Michael Prencipe