Abstract: This invention relates to oral care compositions comprising a zinc source comprising zinc oxide and zinc citrate; a stannous source comprising stannous pyrophosphate; a fluoride ion source comprising sodium fluoride; and an organic buffer, as well as to methods of using and of making these compositions.

Abstract: An example article may include a dental surface, a hydrophobic coating on the dental surface, and a restorative layer on the hydrophobic coating. An example technique may include applying, on a dental surface, a hydrophobic coating comprising an amphiphilic agent. The hydrophobic coating may provide a water contact angle of greater than or equal to about 50° on the dental surface. The example technique may include applying a restorative layer to the hydrophobic coating. An example kit may include a dental restorative composition and a hydrophobic coating composition. The hydrophobic coating composition may include an amphiphilic agent. The hydrophobic coating composition may be configured to provide a water contact angle of greater than or equal to about 50° on a dental surface.

Abstract: The present disclosure provides low water dentifrice compositions comprising an effective amount of a zinc ion source, a tin ion source, a polyphosphate and an acid. The acid lowers the pH of the composition to enable stabilization of the metal ions and extend shelf-life of the composition.

Abstract: This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

Abstract: Methods produce a three-dimensional dental block of material from a dental, polymerizable material. The methods include at least: transferring the polymerizable dental material into a radiolucent three-dimensional casting or press mold; irradiating the polymerizable dental material substantially from all sides with light in the UV/Vis spectral region forming polymerized outer surfaces of the dental material in the form of a solid outer shell of the dental material, wherein the shell is present in the defined three-dimensional geometry of the material whilst the inner region of the material is not polymerized or partially polymerized; heating the material with solid shell being present in defined three-dimensional geometry, to 60° C. to 150° C. for at least 90 minutes; and obtaining a dental, polymerized block of material having defined three-dimensional geometry.

Abstract: The present disclosure provides biophotonic topical compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and their uses are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

Abstract: Provided herein is a storage stable non-fluoride toothpaste composition enriched with a dietary supplement containing both oil soluble and water soluble vitamins. The dietary supplement is incorporated into the toothpaste, the dietary supplement containing a water soluble vitamin portion including at least one water soluble vitamin and an oil soluble vitamin portion. The oil soluble vitamin portion includes at least one oil soluble vitamin, a carrier oil and an emulsifier. The toothpaste is thereby formulated in a manner such that oral application will result in systemic delivery of at least a portion of the dietary supplement to meet a 2% RDI threshold even when 3 or less serving sizes are orally applied.

Abstract: A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.

Abstract: The present invention relates to an antibacterial composition which, when applied to the surface of a tooth, allows remineralisation of the enamel to occur, said composition having very low toxicity for human use. When applied, the composition leaves no stains and does not alter the visible colour characteristics of the teeth to which it has been applied.

Abstract: Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

Abstract: A method of inhibiting or reducing inflammation in a mammal comprises administering MCP or similar Gal-3 binding moiety with honokiol in a range of about 8-10:1, by weight, MCP to honokiol. By pursuing complimentary pathways, a synergistic combination is achieved, where the reduction or degree of inflammation inhibition is greater than would be expected by the added administration of these two agents. The inflammation may be manifested as gingivitis, which may be addressed by a preparation comprising honokiol and MCP, or an MCP equivalent, in the indicated range by weight, where they are in the form of an oral rinse, lozenge, sucking candy, toothpaste or tablet.

Abstract: An organic toothpaste is a Pickering emulsion having a particle stabilizer bound in the interface between the continuous phase and dispersed phase of the emulsion. The particle stabilizer prevents the dispersed phase from coalescing and phase separating. The emulsion may include glycerin and water to form the emulsion and particles, such as erythritol and/or rice powder as the stabilizer. An organic toothpaste may be certified USDA organic and contain no more than 5% by weight of components list of allowed substances, found in the Electronic Code of Federal Regulations, Subpart G published on May 24, 2018. An organic toothpaste may include a foaming component such as saponin, soapbark, decyl glucoside or Quillaja saponaria. In addition, an organic toothpaste may include a natural sweetener such as agave, xylitol or erythritol.

Abstract: A dental care system having from about 30 to 99 wt. % humectant; from about 1 to 50 wt. % water; from about 0.001 to 5.00 wt. % antiplaque and anti-tartar actives; from about 0 to 25 wt. % oil; from about 25 to 1 wt. % surfactant; and wherein the dental care system is hydrophobic and adheres to wet gums.

Abstract: Antioxidative stress compositions, methods of using antioxidative stress composition and methods of preparing antioxidative stress composition compositions are described. The antioxidative stress compositions may be chemopreventive and/or immunomodulatory. Resveratrol, genistein, ellagic acid, curcumin and quercetin may be included in the antioxidative stress composition compositions individually or in any combination.

Abstract: Modelling material which contains (a) at least one radically polymerizable monomer, (b) at least one initiator for the radical polymerization and (c) at least one inert component. The inert component (c) is selected from phthalates, polyethylene glycols (PEG), polypropylene glycols (PPG), PEG-PPG copolymers, glycerol derivatives, ethoxylated or propoxylated glycerol, ethylenediamine tetrakispropoxylates and ethylenediamine tetrakisethoxylates. The material is suitable in particular for the production of models of dental restorations for investment casting processes.

Abstract: Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions. Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.

Abstract: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.

Abstract: Copper ion treatments and methods of treatment are provided to treat various body conditions affecting the oral, respiratory and/or otic areas of the body. The copper ion treatments contain copper ions which bring about local and systemic therapeutic effects as a result of contacting anatomical tissue of the oral cavity, the nasal passages or ear canal. The copper ion treatments and methods involve copper ion-containing solutions, copper ion toothpaste and copper ion mouthwash. The copper ion-containing solutions can be delivered to the oral cavity by spraying or swabbing, can be delivered to the nostrils as spray, drops, or by swabbing, and can be delivered to the ear canal as spray, drops, or by swabbing. The copper ion toothpaste is used for brushing the teeth, and the copper ion mouthwash is used for rinsing the mouth.

Abstract: The composition and method for the use of stabilized chlorine dioxide as an antimicrobial agent against oral microorganisms for the treatment and prevention of halitosis and prevention of oral diseases, wherein the activation and release of chlorine dioxide from the composition a) occurs rapidly and without a period of induction, b) results from the oxidative reduction and consumption of amino acids and volatile sulfur compound precursors, and c) generates twice the available chlorine dioxide gas as that generated from simply lowering the pH of the composition. The preferred concentrations of stabilized chlorine dioxide in this invention are in the range of 0.005% to 2.0% (w/v) wherein the pH of the composition is initially lowered by a citrate and then stabilized by a peroxy compound.

Abstract: Fluorescent nanoparticle compositions and methods of used for dental bonded restorations are provided herein.

Abstract: The present invention relates to a organopolysiloxane graft polymer including an organopolysiloxane segment as a main chain thereof and an unsaturated monomer-derived polymer segment as a side chain thereof, in which the unsaturated monomer-derived polymer segment contains a repeating unit derived from N,N-dimethyl acrylamide in an amount of not less than 50% by mass and not more than 100% by mass, and a content of the organopolysiloxane segment in the organopolysiloxane graft polymer is not less than 10% by mass and not more than 70% by mass.

Abstract: An oral care composition comprising high water oral care compositions comprising an orally acceptable carrier, zinc phosphate, a first stannous ion source (i.e., stannous fluoride), and a second stannous ion source (i.e., stannous chloride). Methods and uses for this composition are also described throughout.

Abstract: Cosmetic or pharmaceutical compositions are described herein for application to skin, hair and/or a nail of a subject, as well as methods utilizing same for administering hydrogen peroxide to skin, hair and/or a nail, and kits for applying same. The compositions comprise a hydrogen peroxide-producing enzyme, and a substrate of the hydrogen peroxide-producing enzyme. Further described herein are cosmetic compositions and kits for lightening skin and/or hair, which further comprise a lignin peroxidase, as well as cosmetic methods utilizing same.

Abstract: The present disclosure provides for systems and methods including pre-moistened dressings with a treatment composition, wherein the dressings can include a water proof occlusive material on one side and an absorbing material for the treatment composition, thereby enabling direct contact transfer of the treatment composition to the skin surface. The treatment composition can include 2-70% wt/vol of a magnesium complex in water. The dressings can be replaced every one to three days for a total treatment time of one to 36 days or more. The treatment systems can be used to treat psoriasis and chronic inflammation, among others.

Abstract: Oral compositions containing a carrier, a cationic antimicrobial compound, and a silica and/or silicate material are disclosed. These compositions can provide a controlled release of the antimicrobial compound.

Abstract: Disclosed herein is mucin-coated silica, compositions comprising the same, and methods of promoting the aggregation and/or clearance of oral bacteria using such compositions.

Abstract: The presently disclosed subject matter provides lactone-containing malodor eliminating compositions that ameliorate undesirable malodor, e.g., undesirable malodor due to presence of sulfur- or amine-containing compounds. The presently disclosed compositions can be added to a variety of products, including, but not limited to, foods, beverages, toothpastes, mouthwashes and other orally consumable products.

Abstract: The present invention relates to a method for producing a liquid composition for oral cavity in which ?-glycyrrhetinic acid is stably dispersed or dissolved to exhibit an increased transparency and which also can ensure a sufficient amount of ?-glycyrrhetinic acid adsorbed on gingiva, even if the amount of a cationic surfactant or an anionic surfactant is restricted; and such a liquid composition for oral cavity. Specifically, the present invention relates to a method for producing a liquid composition for oral cavity, comprising the following step 1 to step 4: (Step 1) a step of blending water (F) with an organic acid and a salt thereof (E) to adjust the pH of a resultant mixture to 5 or more and 6.8 or less, (Step 2) a step of blending 0.02% by mass or more and 0.1% by mass or less of cetylpyridinium chloride (B) into the mixture, (Step 3) a step of blending 0.02% by mass or more and 0.

Abstract: The present disclosure relates to a formulation for a non-hazardous, organic preservative system. The preservative system comprises water, an alcohol, xylitol, and lemon grass essential oil in quantities which ensure preservative qualities without compromising the compound or substance that is being preserved.

Abstract: A method for extracting substances from a fecal sample using mass spectrometry or nuclear magnetic resonance spectrometry, and metagenomic analysis using a next-generation sequencer.

Abstract: A toothpaste composition having a plant oil constituent together with white or a close shade of white coconut shell activated charcoal constituent is disclosed herein.

Abstract: An oral care composition containing at least 4% fatty amphiphile and from about 0.4% to about 5%, by weight of the composition, total flavor components. The flavor components contain at least 14%, by weight of the flavor components, of one or more high displaying flavor components.

Abstract: The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.

Abstract: The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.

Abstract: A multifunctional dental composition may include polyoxyethylene sorbitan monooleate; sorbitan monooleate; benzoate sodium; distilled water; and ethylene diamine tetra acetic acid. For dental use, the required hydrophilic/lipophilic balance of the composition may be 7; and a critical micellar concentration of the composition may be 0.5%. The dental composition may be applied in a manner similar to how tap water is conventionally used, and the composition may be delivered to the dental unit system using various methods.

Abstract: The presently disclosed subject matter provides fragrance compositions and fragrance combinations that can stimulate the trigeminal system. The compositions and combinations of the presently disclosed subject matter can include both one or more trigeminal-stimulating compounds and one or more additional fragrance compounds. The trigeminal-stimulating compounds can include cooling, warming, and tingling compounds.

Abstract: A tooth whitening composition includes a whitening component; a metal ion chelator; water; and polyalcohol, the weight ratio of the water and the polyalcohol being, water:polyalcohol=3.5:1 to 20:1, and also, the total amount of the water and the polyalcohol, in the composition, being greater than or equal to 50 wt. % and less than or equal to 85 wt. %.

Abstract: Disclosed herein, in part, is a pharmaceutical formulation comprising isotretinoin or a pharmaceutically acceptable salt thereof, and a mucoadhesive polymer. A method of treating a mucosal disease comprising administering a disclosed pharmaceutical formulation to a subject in need thereof is also provided herein.

Abstract: The invention provides a powder oral hygiene composition comprising xylitol, a source of carbon dioxide, an acid and an absorbent, wherein the composition has a water surface area greater than 160 m2/g.

Abstract: A disposable toothbrush having a toothpaste composition distributed over the bristles of the toothbrush without the use of metal graft initiators and catalysts, and in which the toothpaste and the flavoring is maintained for an extended period of time.

Abstract: Oral care compositions having polyethylene glycol are more phase stable, particularly with certain flavorants that have a specified range of Dielectric Constant and/or water number and/or C log P value.

Abstract: The present invention relates to a composition for use as component of a multicomponent resin-modified glass ionomer cement, to a multicomponent resin-modified glass ionomer cement and also to a process for the preparation of the corresponding compositions and of cured dental materials. The invention furthermore relates to the corresponding use of one or more compounds (S) selected from the group consisting of sulfinic acids, salts of sulfinic acids and salts of organoboron compounds.

Abstract: Compositions and methods for preventing, ameliorating or treating biofilm infections are provided, including biofilms comprising at least one Pseudomonad or Staphylococcus, such as S. aureus. The biofilm infections may be associated with artificial joints, prostheses or implants.

Abstract: A tooth whitening composition includes a hydrophobic copolymer, a hydrophilic whitening agent and a polar solvent.

Abstract: Disclosed herein, in part, is a pharmaceutical formulation comprising isotretinoin or a pharmaceutically acceptable salt thereof, and a mucoadhesive polymer. A method of treating a mucosal disease comprising administering a disclosed pharmaceutical formulation to a subject in need thereof is also provided herein.

Abstract: Oral care compositions consisting essentially of a Sea Salt, at least one essential oil, xylitol, and preferably, aloe vera juice and uses of such compositions to whiten teeth, reduce sensitivity of teeth/gums, and reduce xerostomia. In preferred embodiments directed to teeth whitening and xerostomia, the compositions also include coconut oil. Delivery systems for whitening teeth comprised of a strip formed be combining (i) one or a combination of teeth whitening ingredients selected from Dead Sea Salt, Cocos Nucifera (Coconut) Oil, Citrus Limon (Lemon) Peel Oil, and Salvia Officinalis (Sage) Oil and (ii) one or more gelling/thickening agents, wherein the strip is conformable to teeth surfaces and to interstitial spaces between teeth, without permanent deformation thereof, and is removably attached to a release liner. The strips may also contain one or more peroxides, metal chlorites, perborates, percarbonates, and peroxyacids.

Abstract: Antimicrobial compositions providing synergistic antimicrobial effects against a variety of bacterial, viral and fungal organisms are described. Methods for using the antimicrobial compositions and products containing the antimicrobial compositions are also described herein.

Abstract: The present invention provides rechargeable dental materials that can be widely applied in a variety of dental applications. The rechargeable dental materials of the invention may be included in dental primers, dental adhesives, dental resins, dental composites, dental bonding systems and the like, as well as dental cements, dental sealants, dental bases and dental liners, each of which is rechargeable with calcium and phosphate ions. The present invention also provides for a method of recharging the rechargeable dental material with calcium and phosphate ions.

Abstract: The present invention is directed to a method of achieving improved hair volume comprising applying to hair a composition comprising from about 0.25% to about 80% of a pre-emulsified emulsion comprising from about 0.005% to about 80% of one or more materials selected from the group comprising metathesized unsaturated polyol esters, sucrose polyesters, fatty esters with a molecular weight greater than or equal to 1500 and mixtures thereof or, by weight of said hair care composition; wherein an emulsifier is selected from the group consisting of anionic, non-ionic, cationic, amphoteric and mixtures thereof wherein the average particle size of the pre-emulsified emulsion is from about 20 nanometers to 20 microns; from about 5% to about 50% of one or more anionic surfactants, by weight of said hair care composition; from about 0.

Abstract: Compositions and methods of manufacture for an extended time-release fragrance comprising volatile organic compounds. A composition of the disclosure includes an effective amount of a volatile organic compound for providing a fragrance that can be sensed by a user and fractionated coconut oil comprising caprylic acid and capric acid.