Polycyclo Ring System Containing The Hetero Ring As One Of The Cyclos Patents (Class 540/203)
  • Patent number: 4923983
    Abstract: Cis .alpha..alpha./.beta..beta.-3-amino-[2-(2-furyl)eth-1-yl]-1-methoxycarbony lmethyl-azetidin-2-one is resolved via optically active tartaric acid.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: May 8, 1990
    Assignee: Eli Lilly and Company
    Inventor: Ian G. Wright
  • Patent number: 4876251
    Abstract: The compounds, having a 4,10-dioxo-3-oxa-7-thia-1-azatricyclo[6,2,0,0.sup.2,6 ]decane-2-carboxylic acid skeleton as the base structure, their esters and their salts, are useful antibacterial agents.
    Type: Grant
    Filed: June 9, 1987
    Date of Patent: October 24, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Akira Morimoto, Nobuo Choh, Noriyoshi Noguchi
  • Patent number: 4824849
    Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: April 25, 1989
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Joel R. Huff, Joseph P. Vacca, Steven D. Young, Jane deSolms, James P. Guare, Jr.
  • Patent number: 4754029
    Abstract: 3-Oxo-2-azabicyclohexane derivatives represented by the general formula: ##STR1## wherein R.sub.1 represents an optically active menthoxy group or an optically active 1-phenylethoxy group when R.sub.2 and R.sub.3 are combined to form a bond; when R.sub.3 is a hydrogen atom, R.sub.1 and R.sub.2 are combined to form an oxo group or, R.sub.2 is a hydrogen atom and R.sub.1 is a hydroxy group or a lower alkanoyloxy group. The 3-oxo-2-azabicyclohexane derivatives are novel compounds useful as intermediates for antibacterial agents.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: June 28, 1988
    Assignee: Eisai Co., Ltd.
    Inventors: Chikara Kaneko, Masayuki Sato, Nobuya Katagiri
  • Patent number: 4710504
    Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: December 1, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Joel R. Huff, Joseph P. Vacca, Steven D. Young, Jane deSolms, James P. Guare, Jr.
  • Patent number: 4692515
    Abstract: Biologically active substituted spiro[azetidin-2-one-4,2'(or 3,2')adamantanes] of the formula ##STR1## where R is hydrogen, --SO.sub.2 Cl, or alkyl, and one of R.sup.1 and R.sup.2 is an adamantyl group which shares a ring carbon with the lactam group and the other is alkyl, substituted alkyl, phenyl, or substituted phenyl, are disclosed herein.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: September 8, 1987
    Assignee: Pennwalt Corporation
    Inventors: Vassil S. Georgiev, George B. Mullen
  • Patent number: 4684722
    Abstract: Antibacterial activity is exhibited by monocyclic .beta.-lactam antibiotics having in the 1-position an --O--SO.sub.3 H activating group and in the 3-position an acylamino group of the formula ##STR1## wherein R.sub.3 and R.sub.4 are each independently hydrogen or alkyl.
    Type: Grant
    Filed: January 6, 1986
    Date of Patent: August 4, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Joseph E. Sundeen
  • Patent number: 4680388
    Abstract: Antibacterial activity is exhibited by compounds having the formula and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: July 14, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, William H. Koster, Robert Zahler
  • Patent number: 4638060
    Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: January 20, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, William H. Koster, Robert Zahler
  • Patent number: 4616084
    Abstract: A process for the preparation of a 7-acylamino-3-hydroxy-2-cephem-4-carboxylic acid, 7-acylamino-3-hydroxy-1-dethia-1-oxa-3-cephem-4-carboxylic acid or derivative thereof of the general formula ##STR1## in which R.sup.1 is hydrogen or optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl, heteroaryl, heteroaralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, arylthioalkyl, heteroarylthioalkyl, alkylthioalkyl, alkoxy, aryloxy, alkylthio or arylthio,R.sup.2 is hydrogen, a carboxy-protective group or a pharmaceutically useful ester radical, andX is sulphur or oxygen,which comprises:(a) reacting a compound of the formula ##STR2## with (i) a compound of the formula ##STR3## in which R.sup.2 and X have the abovementioned meaning and Y represents diazo (N.sub.2) or hydrogen (H.sub.2) in an inert solvent in the presence of a Lewis acid or proton acid catalyst, or(ii) a compound of the formulaHX--CH.sub.2 --C.tbd.C--COOR.sup.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: October 7, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dieter Habich, Wolfgang Hartwig