The Ring Nitrogen Is Shared By A Five-membered Ring Patents (Class 540/302)
  • Patent number: 4644061
    Abstract: Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula ##STR1## in which A represents a C.sub.1 -C.sub.6 straight or branched chain alkylene group; R.sup.5 represents an optionally substituted aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aryl, araliphatic, heteroaryl, heteroaraliphatic, heterocyclyl or heterocyclyl-aliphatic radial and ##STR2## represents a nitrogen-containing aromatic heterocycle attached to the alkylene group A at a ring carbon atom and quaternized by substituent R.sup.5. Such derivatives are useful as potent antibacterial agents.
    Type: Grant
    Filed: February 22, 1985
    Date of Patent: February 17, 1987
    Assignee: Bristol-Myers Company
    Inventor: Choung U. Kim
  • Patent number: 4642341
    Abstract: Disclosed are novel carbapenem derivatives characterized by a 2-substituent of the formula ##STR1## in which A represents cyclopentylene, cyclohexylene or C.sub.2 -C.sub.6 alkylene optionally substituted by one or more C.sub.1 -C.sub.4 alkyl groups and ##STR2## represents a quaternized nitrogen-containing aromatic heterocycle. Such derivatives are useful as potent antibacterial agents. Also disclosed are processes for the preparation of such derivatives and novel intermediates utilized in these processes.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: February 10, 1987
    Assignee: Bristol-Myers Company
    Inventors: Choung U. Kim, Peter F. Misco, Jr.
  • Patent number: RE32465
    Abstract: Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline earth metal carbonate, followed by reaction of the thereby formed 1-imido-4-substituted-azetidine-2-one with a trialkyl phosphite.Also described are novel penems useful as antibacterials which are prepared by the described process.
    Type: Grant
    Filed: May 29, 1985
    Date of Patent: July 28, 1987
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, Frank Hon