Determining Constituents In Eye Patents (Class 600/318)
  • Publication number: 20120245440
    Abstract: The invention provides high speed, low cost scanning suitable for time domain OCT systems. According to the preferred embodiment, the apparatus includes a piezo scanning device and partial reflecting surfaces that simultaneously generate two sets of multiple reference signals at two different wavelengths that can span different regions of a target enabling acquiring target information from a large range within the target. In one embodiment of the invention, information from both the front region and the back region of an eye is acquired in a coordinated manner.
    Type: Application
    Filed: March 24, 2012
    Publication date: September 27, 2012
    Inventor: Josh N. HOGAN
  • Patent number: 8249682
    Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: August 21, 2012
    Assignee: Lacrisciences, LLC
    Inventors: Anthony P. Cappo, Gregory Bennett, Jeffrey P Gilbard, Paul T Gavaris, Diptabhas Sarkar
  • Patent number: 8241574
    Abstract: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: August 14, 2012
    Assignee: Smart Holograms Limited
    Inventors: Barry Burles, Roger Bradley Millington, Christopher Robin Lowe, Satyamoorthy Kabilan, Jeffrey Blyth
  • Patent number: 8219169
    Abstract: A method determines the concentration of a substance in a subject's blood. The method includes noninvasively irradiating an eye with a measurement light beam having a first wavelength and a first power and with a reference light beam having a second wavelength and a second power. The second wavelength is different from the first wavelength. The method further includes measuring at least one of a body temperature of the subject and an ambient temperature of the subject. The method further includes detecting a power of the measurement retro-reflected light beam and detecting a power of the reference retro-reflected light beam. The method further includes calculating a measurement ratio of the detected power of the measurement retro-reflected light beam and the first power and calculating a reference ratio of the detected power of the reference retro-reflected light beam and the second power.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: July 10, 2012
    Assignee: GlucoVista Inc.
    Inventor: Jonathan Gerlitz
  • Patent number: 8144960
    Abstract: A method and system for non-invasively measuring the concentration of an optically-active substance in a subject are provided. The system includes a light source adapted to transmit light towards a subject or object having a concentration of an optically-active substance, a polarizer positioned between the light source and the subject, an image capturing device, and a processor. The image capturing device is positioned to receive light reflected from the subject and create a measured image therefrom. The measured image defines measured light intensity data. The processor is configured to calculate a concentration of the optically-active substance based on a selected portion of the measured light intensity data.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: March 27, 2012
    Inventor: Dale E. Winther
  • Publication number: 20120041552
    Abstract: Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s).
    Type: Application
    Filed: July 18, 2011
    Publication date: February 16, 2012
    Inventors: Roy S. Chuck, George Baerveldt, Jim-Son Chou
  • Patent number: 7998412
    Abstract: An ophthalmic device which comprises a holographic element comprising a medium comprising a phenylboronic acid group and, disposed therein, a hologram, wherein an optical characteristic of the element changes as a result of a variation of a physical property of the medium, and wherein the variation arises as a result of interaction between the medium and an analyte present in an ocular fluid.
    Type: Grant
    Filed: February 16, 2008
    Date of Patent: August 16, 2011
    Assignee: Smart Holograms Limited
    Inventors: Barry Burles, Roger Bradley Millington, Christopher Robin Lowe, Satyamoorthy Kabilan, Jeffrey Blyth
  • Publication number: 20110184261
    Abstract: A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 28, 2011
    Inventor: Naresh Menon
  • Publication number: 20110184262
    Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 28, 2011
    Inventor: Naresh Menon
  • Publication number: 20110040161
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: July 8, 2010
    Publication date: February 17, 2011
    Inventor: Marcio Marc Abreu
  • Publication number: 20110028807
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: July 8, 2010
    Publication date: February 3, 2011
    Inventor: Marcio Marc Abreu
  • Patent number: 7809417
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: October 5, 2010
    Inventor: Marcio Marc Abreu
  • Publication number: 20100249548
    Abstract: An ocular sensor (110) is proposed for verification of at least one analyte in an eye fluid. The ocular sensor (110) is composed of at least one sensor material which is designed to change at least one optical characteristic in the presence of the at least one analyte. Furthermore, the ocular sensor (110) comprises at least one sensor chip which has at least one integrated optical detector (122) for verification of the optical characteristic. A measurement system (166) is also proposed for verification of at least one analyte in an eye fluid, which measurement system (166) comprises an ocular sensor (110) according to the invention as well as an evaluation unit (168) which is designed to interchange information with the sensor chip (118).
    Type: Application
    Filed: January 14, 2008
    Publication date: September 30, 2010
    Inventor: Achim Müller
  • Patent number: 7769419
    Abstract: A method and apparatus for measuring an apparent depth (1) of a section of an eye (30) are disclosed. Light is focused to a measurement location (15) proximate or within the eye. The measurement location is scanned through the section and upon passing through first and second refractive index interfaces defining the section, a respective reflected light signal is detected, from which apparent positions of the first and second interfaces may be derived. Preferably, a confocal scanning arrangement is employed. Preferably, the section is the aqueous humor (34) of the eye (30). From changes in its refractive index (n) corresponding changes in glucose concentration in the aqueous humor and, in turn, in the bloodstream of a patient may be derived, offering a non-invasive monitoring means for diabetic patients. The apparatus may be a hand-held device, employing microelectromechanical systems.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: August 3, 2010
    Assignee: Lein Applied Diagnostics Limited
    Inventor: Daniel John Daly
  • Patent number: 7756559
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: July 13, 2010
    Inventor: Marcio Marc Abreu
  • Patent number: 7706863
    Abstract: In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of: (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: April 27, 2010
    Assignee: University of Washington
    Inventors: Yoshikazu Imanishi, Krzysztof Palczewski, Bryan S. Sires, Eric J. Seibel
  • Patent number: 7653428
    Abstract: The invention provides a method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or supranuclear regions of an ocular lens of the mammal.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: January 26, 2010
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Lee E. Goldstein, Leo T. Chylack, Jr., Ashley Ian Bush
  • Patent number: 7643859
    Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: January 5, 2010
    Assignee: GlucoVista, LLC
    Inventor: Jonathan Gerlitz
  • Publication number: 20090149726
    Abstract: Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed.
    Type: Application
    Filed: December 11, 2007
    Publication date: June 11, 2009
    Inventors: Roderick A. Hyde, Nathan P. Myhrvold, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20090118601
    Abstract: A method for detecting disease in a patient includes providing infrared (IR) light and coupling the IR light through direct lens coupling or through a first group of one or more optical fibers. IR light is reflected from a portion of the patient and collected by a lens arrangement or a second group of one or more optical fibers. The reflected IR light is dispersed into its spectrum which is detected and analyzed. An apparatus suitable for diagnosing a disease in a patient includes an IR light source and optical fiber or direct lens coupling of IR light onto a body part or fluid of the patient. Reflected light from the patient is optically dispersed using a prism or grating. An IR focal plane array receives the optically dispersed light. The spectrum of the reflected IR light is used to provide a diagnosis of disease in the patient by identifying various disease markers or chemical fingerprints. The method and apparatus are capable of non-invasively detecting disease markers in a patient.
    Type: Application
    Filed: September 29, 2005
    Publication date: May 7, 2009
    Applicants: UNIVERSITY OF DELAWARE, MATERIALS RESEARCH SERVICES
    Inventors: John F. Rabolt, Mei-Wei Tsao
  • Publication number: 20090099428
    Abstract: A method of performing a diagnostic characterization and assessment of a patients' eye is provided. The method comprising the extraction of measurement data relating to a predetermined portion of the eye, for example the fovea, at a plurality of wavelengths and fitting the extracted measurement data to a model of the eye, for example a linear adaptive model. The data subsequently analyzed to determine at least one of a common retinal behavior, a deviation from the common retinal behavior, and an oximetry value. In the case of the measurement data relating to the fovea of the eye then the oximetry value is indicative of the blood oxygen saturation of the choroid vasculature of the eye. Further analysis based upon storing the measurement data and/or analysis from each test allows for the changes within the patients eye to be established unlike prior art solutions, and identifying the changes with an element of the eye such as the retina, cornea, crystalline lens, etc.
    Type: Application
    Filed: October 2, 2008
    Publication date: April 16, 2009
    Applicant: Evasight Instruments Inc.
    Inventors: Rejean J. Munger, Orazio Berolo
  • Patent number: 7502639
    Abstract: Retinal metabolism is analyzed with a retinal function camera over at least a portion of a cardiac cycle by first illuminating a portion of a retina of an eye 10 with light of a first wavelength and producing a first image. The portion of the retina is subsequently illuminated with light of a second wavelength, the first and second wavelengths being selected such that absorptivity of light of the first wavelength by oxygenated blood is greater than absorptivity of light of the second wavelength and the absorptivity of light of the first wavelength by deoxygenated blood is less than absorptivity of light of the second wavelength, to produce a second image. The first and second images are processed to map relative oxygenation of the portion of the retina as an indication of retinal metabolic function of the portion of the retina.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: March 10, 2009
    Inventor: Patrick Kerr
  • Publication number: 20090036761
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: June 13, 2008
    Publication date: February 5, 2009
    Inventor: Marcio Marc Abreu
  • Publication number: 20090018419
    Abstract: Biosensor, communicator, and/or controller apparatus, systems, and methods are provided for monitoring movement of a person's eye. The apparatus includes a device configured to be worn on a user's head, a light source for directing light towards one or both eyes of the user, one or more image guides on the device for viewing one or both eyes of the user, and one or more cameras carried on the device and coupled to the image guides for acquiring images of the eyes and/or the user's surroundings. The apparatus may include a cable and/or a transmitter for transmitting image data from the camera to a remote location, e.g., to processor and/or display for analyzing and/or displaying the image data. A system including the apparatus may be used to monitor one or more oculometric parameters, e.g., pupillary response, and/or to control a computer using the user's eyes instead of a mouse.
    Type: Application
    Filed: April 1, 2005
    Publication date: January 15, 2009
    Inventor: William C. Torch
  • Patent number: 7474775
    Abstract: Disclosed is an automated method which can detect images containing red lesions. First, each image is preprocessed; next, candidate objects that may represent red-lesions are extracted; and in the final stage the probability for each candidate to represent a red-lesion is estimated using a classifier and a large set of specifically designed features.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: January 6, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Michael D. Abràmoff, Bram van Ginneken, Meindert Niemeijer
  • Publication number: 20090005660
    Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.
    Type: Application
    Filed: September 6, 2007
    Publication date: January 1, 2009
    Inventors: Anthony P. Cappo, Gregory Bennett, Jeffrey P. Gilbard, Paul T. Gavaris, Diptabhas Sarkar
  • Patent number: 7450981
    Abstract: An apparatus for measuring a blood component using the trans-reflectance of light irradiated to a transflective member disposed behind a test site. The apparatus includes an optical source unit irradiating light to the test site of a test subject; a transflective unit transflecting light transmitted through the test site; a detection unit detecting the transflected light; and an analysis unit analyzing the transflected light detected in the detection unit. A related method includes irradiating the light to the test site; transflecting light through the test site, detecting the transflected light, and analyzing the detected light. Blood component measurement can be easily performed without collecting blood by analyzing the transflected light with a high optical power containing much information about a blood component.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: November 11, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Kye-Jin Jeon
  • Publication number: 20080221416
    Abstract: Embodiments of the present invention relate to a system and method of detecting or monitoring macular degeneration in a patient. One embodiment of the present invention includes emitting a first light into the patient's retinal tissue at a first wavelength, emitting a second light into the patient's retinal tissue at a second wavelength, detecting the first and second lights after dispersion by the retinal tissue, and determining an amount of lipid proximate the retinal tissue based on the detected first and second lights.
    Type: Application
    Filed: March 9, 2007
    Publication date: September 11, 2008
    Inventor: Clark R. Baker
  • Publication number: 20080214913
    Abstract: The present invention provides a spectroscopic apparatus, a method and a computer program product for determining the concentration of an analyte of a fluid that flows through a capillary vessel of a biological sample. The spectroscopic apparatus makes use of an imaging system for determining the position of at least one biosensing substrate that has been implanted into the biological sample in the proximity of the capillary vessel but outside the capillary vessel. The biosensing substrate is capable of inducing surface-enhanced spectroscopic effects and is preferably adapted to reversibly and selectively bind a certain analyte or molecule of the fluid, to which the vessel wall of the capillary vessel is at least semi-permeable.
    Type: Application
    Filed: February 16, 2006
    Publication date: September 4, 2008
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.
    Inventors: Antonius Theodorus, Martinus Van Gogh, Gert 'T Hooft, Gerhardus Wilhelmus Lucassen
  • Patent number: 7406345
    Abstract: The present invention relates to a hand-held fluorescence photometer and method for measuring an analyte level, preferably a blood glucose level, from an ocular fluid. The photometer is based on a dual beams measuring system and it is capable of defining the correct positioning for the measurement. Only when the apparatus is correctly positioned the actual analyte measurement automatically takes place.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: July 29, 2008
    Assignee: Eyesense AG
    Inventors: Achim Müller, Roland Schmieder, Klaus Haberstroh
  • Patent number: 7403805
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: July 22, 2008
    Inventor: Marcio Marc Abreu
  • Patent number: 7398119
    Abstract: A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier. Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam at a selected wavelength (e.g., at a wavelength of about 400 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 8, 2008
    Assignees: Childrens Hospital Los Angeles, California Institute of Technology
    Inventors: James L. Lambert, Mark S. Borchert
  • Patent number: 7395103
    Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine osmolarity of the tear sample.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: July 1, 2008
    Assignee: Osmopen, LLC
    Inventors: Anthony P. Cappo, Gregory Bennett
  • Patent number: 7308293
    Abstract: An apparatus for measuring a concentration of a substance in an eye (13) includes a measurement light source (4) producing a measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient. The apparatus further includes a reference light source (6) producing a reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. At least a portion of the measurement light beam retro-reflects from the retina (17) and at least a portion of the reference light beam retro-reflects from the retina (17). The apparatus further includes a detector (9) responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: December 11, 2007
    Assignee: GlucoVista, LLC
    Inventor: Jonathan Gerlitz
  • Patent number: 7266402
    Abstract: Provided are an apparatus and a method for determining blood sugar level without blood using dark adaptation of the optic nerve, and a computer-readable recording medium storing a computer program performing the method. The apparatus irradiates stimulating light onto the pupil of a subject. A detecting device determines when the subject responds to the light. A calculator then calculates the blood sugar based on the response to the stimulating light.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: September 4, 2007
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kye-jin Jeon, Ji-deog Kim, In-duk Hwang
  • Patent number: 7229175
    Abstract: An ophthalmic image sensing apparatus includes an examination optical system for examining an eye to be examined, an image sensing optical system for sensing an image of the eye to be examined, an examination image pickup element for picking up the image of the eye to be examined through the examination optical system, an image-sensing image pickup element for picking up the image of the eye to be examined through the image sensing optical system, an examination condition setting device for determining image sensing states of the examination optical system and the examination image pickup element, and a driving device for determining image sensing states of the image sensing optical system and the image-sensing image pickup element based on the examination conditions determined by the examination condition setting device.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: June 12, 2007
    Assignee: Canon Kabushiki Kaisha
    Inventor: Hiroshi Itoh
  • Patent number: 7222961
    Abstract: A system and method for detecting a functional signal in retinal images. An optical imaging device comprises a stimulation light source, an interrogating light source, and a detector. The retina is stimulated by the stimulation light source. The retina is then illuminated by an interrogation light, and the reflected intensity from the retina is measured at an interrogating spectral band that indicates the state of hemoglobin saturation before and after visual stimulation. The optical changes that result from retinal neuronal activity are captured by the detector. The signal representing the state of hemoglobin saturation before and after visual stimulation is isolated. In an embodiment of the present invention, this signal is isolated using principle components analysis (PCA).
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 29, 2007
    Assignee: Kestrel Corporation
    Inventors: Peter Soliz, Eduardo S. Barriga
  • Patent number: 7209773
    Abstract: An in-vivo blood composition analyzing apparatus and method generates a laser beam at the blood vessels of the patient's eye. The Raman scattered photons from the blood vessels are collected and used to generate a Raman spectrum indicative of the blood composition. In one embodiment, a laser beam is generated with two streams of photons, the photons of one beam being entangled with the photons of the other beam. One stream is then directed at the eye and only the other beam is analyzed to obtain said Raman spectrum. Alternatively, the scattered photons from the second beam are also analyzed and the results are correlated for greater efficiency and accuracy.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: April 24, 2007
    Assignee: In Technology Holdings LLC
    Inventor: Michael J. Iuliano
  • Patent number: 7182509
    Abstract: The invention is an apparatus for determining a temperature at which a phase change occurs in a fluid sample, a method for measuring a temperature at which a phase change occurs in a sample and a sample cell.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: February 27, 2007
    Assignee: Advanced Instruments, Inc.
    Inventor: Christopher J. Corbett
  • Patent number: 7167736
    Abstract: A method and system for non-invasively measuring the concentration of an optically-active substance in a subject are provided. The system includes a light source adapted to transmit light towards a subject or object having a concentration of an optically-active substance, a polarizer positioned between the light source and the subject, an image capturing device, and a processor. The image capturing device is positioned to receive light reflected from the subject and create a measured image therefrom. The measured image defines measured light intensity data. The processor is configured to calculate a concentration of the optically-active substance based on a selected portion of the measured light intensity data.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: January 23, 2007
    Assignee: Q Step Technologies, Inc.
    Inventor: Dale E. Winther
  • Patent number: 7155268
    Abstract: A non-invasive device for measuring blood glucose levels comprises an enclosure with a cover and dual openings, wherein the enclosure is covered with a transparent material (e.g., glass or plastic); at least two test cards arranged at specified distances and positioned within the enclosure; an illuminator and a conical light reflecting surface for casting a beam on the test cards. Light from one test card is reflected through one of the dual openings to sensing receptors of one eye. In order to enable the part of a diffuse beam reflected from the second test card made parallel within 10° to fall on the sensing receptors of the second eye, the enclosure is provided with a tubular prism covered with a closing plate having an opening at a first end while having an opening covered preferably with transparent material at a second end.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: December 26, 2006
    Assignee: Iris Medical Technologies International Ltd.
    Inventor: Gyula Subotics
  • Patent number: 6982090
    Abstract: An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a substance causing at least the outwardly exposed surface to contrast with surrounding tissue, such that the use of the substance causes the plug to be more easily visualized than if the substance were not present. The substance, which may be disposed on the outwardly exposed surface or within the body of the plug, may include a saturated coloration, or may be phosphorescent, fluorescent or otherwise operative to reflect or re-radiate light to assist in visualization. For example, the substance may include an organic or inorganic phosphor or fluorescent material, reflective beads, quantum dots, a dye or pigment. Such reflection or re-radiation may occur at the same or different wavelength(s) compared to the illumination wavelength(s), whether or not either or both are within the visible part of the spectrum.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: January 3, 2006
    Inventor: Donald E. Gillespie
  • Patent number: 6973338
    Abstract: A method for monitoring blood/tissue gases, blood pH, and other elements of blood and tissue chemistry is described that uses a sensor tip that is placed adjacent to the conjunctiva of a patient to be monitored. Monitors and sensor using optical fiber sensors for performing the monitoring are also described.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: December 6, 2005
    Assignee: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Inventors: Sherwin J. Isenberg, Irwin Weiss
  • Patent number: 6968222
    Abstract: The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: November 22, 2005
    Assignee: Oculir, Inc.
    Inventors: John F. Burd, Jacob Fraden, Charles E. Kramer, Gary Krantz, William Sell
  • Patent number: 6965793
    Abstract: Apparatus and methods for spatially resolved Raman detection of molecules indicative of the borders of lesions with normal tissue are disclosed. A region of biological tissue was illuminated with monochromatic light. A Raman shifted light signal is detected from endogenous molecules in the region, the molecules being spatially organized in a localized first area of the region. These molecules are indicative of a border between normal tissue and a lesion. The Raman shifted light signal is then spatially resolved in at least one direction.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: November 15, 2005
    Assignee: ChemImage Corporation
    Inventors: Patrick J. Treado, Matthew P. Nelson
  • Patent number: 6961599
    Abstract: Methods and systems of the present invention identify the presence of and/or the concentration of a selected analyte in a subject by: (a) illuminating a selected region of the eye of a subject with an optical excitation beam, wherein the excitation beam wavelength is selected to generate a resonant Raman spectrum of the selected analyte with a signal strength that is at least 100 times greater than Raman spectrums generated by non-resonant wavelengths and/or relative to signals of normal constituents present in the selected region of the eye; (b) detecting a resonant Raman spectrum corresponding to the selected illuminated region of the eye; and (c) identifying the presence, absence and/or the concentration of the selected analyte in the subject based on said detecting step. The apparatus may also be configured to be able to obtain biometric data of the eye to identify (confirm the identity of) the subject.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: November 1, 2005
    Assignees: Childrens Hospital Los Angeles, California Institute of Technology
    Inventors: James L. Lambert, Mark S. Borchert
  • Patent number: 6954667
    Abstract: Apparatus and methods for spatially resolved Raman detection of calcification in tissues are disclosed. A region of soft non-arterial biological tissue is illuminated with monochromatic light. A spatially organized first area of calcified tissue is then detected in the region by detecting a Raman shifted light signal. The Raman shifted light signal is spatially resolved in at least one direction.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: October 11, 2005
    Assignee: ChemImage Corporation
    Inventors: Patrick J. Treado, Matthew P. Nelson
  • Patent number: 6819949
    Abstract: A method and apparatus are provided for accurately measuring the blood oxygen saturation with a retinal vessel. The apparatus includes an optical source for illuminating the retinal vessel with optical signals. The apparatus also includes a filter, such as an aperture, disposed within the path of the optical signals returning from the eye. The filter preferentially passes single pass optical signals that have diffused through the retinal layer and/or the choroidal layer of the eye while traversing the retinal vessel only once, while blocking or otherwise redirecting the other optical signals. The apparatus also includes a detector for separately detecting at least the single pass optical signals and, in some instances, the other optical signals as well. The apparatus can also include a processing element for determining the blood oxygen saturation in the retinal vessel based upon the optical signals that have been detected.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: November 16, 2004
    Assignee: University of Alabama in Huntsville
    Inventors: Matthew H. Smith, Arthur Lompado, Kurt R. Denninghoff, Lloyd W. Hillman
  • Patent number: 6772000
    Abstract: Described herein is a medical device, such as a catheter or guidewire, which comprises an elongate body, a MRI imaging sensor and a contrast medium contained within the medical device, the contrast medium enhancing the MRI image of body tissue. The contrast medium may be contained or encapsulated in the elongate body, the imaging sensor, or a reservoir(s) in the elongate body or imaging sensor. The contrast medium may be, for example, gadolinium or a superparamagnetic contrast medium.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: August 3, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventor: Dnyanesh Talpade
  • Patent number: RE40316
    Abstract: The concentration of glucose in the anterior chamber of an eye is non-invasively measured by guiding a beam through a polarizer (4), a quarter wave plate (6), a polarization modulator (20), and an analyzer (7). After initializing the polarizer and the analyzer to extinguish the beam, it is guided parallel to the iris (56) of the eye (50) and introduced into the anterior chamber (57), wherein it is refracted, impinges on and is reflected from the iris, and exits the anterior chamber approximately collinear with the portion (55A) of the beam incident on the anterior chamber. The beam then is guided onto a detector (10), and a sufficient signal is applied to the polarization modulator to extinguish the beam. The signal represents the glucose concentration in the patient's blood.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: May 13, 2008
    Inventors: Garth W. Gobeli, Alan J. Leszinske