Abstract: The disclosed subject matter includes devices and systems for extending the imaging capability of swept, confocally aligned planar excitation (SCAPE) microscopes to in vivo applications. In embodiments, the SCAPE microscope can be implemented as an endoscopic or laparoscopic inspection instrument.

Abstract: An endoscope system generates first to third color image data by imaging biological tissue illuminated with first to third light. The endoscope system uses a first light intensity ratio of the first light and the second light, and/or an imaging sensitivity of the image sensor, to correct a first ratio between multiple components of the first and second color image data, and the endoscope system calculates a first characteristic amount of the biological tissue based on the first corrected ratio. Furthermore, the endoscope system uses a second light intensity ratio between the second light and the third light to correct a second ratio between multiple components of the second and third color image data, and the endoscope system calculates a second characteristic amount of the biological tissue based on the second corrected ratio and the first characteristic amount.

Abstract: Systems and techniques for laser surgery are described. Scan data may be created by determining a coordinate of the object at a set of points along an arc by the imaging system, wherein the coordinate of the object is a Z coordinate of an object layer. An object shape parameter and position parameter may be determined based on the scan data by a system control module by extracting an amplitude and a phase of the scan data determining a center of the object layer based on the extracted amplitude and phase.

Abstract: A capsule endomicroscope has a predetermined axial length and a diameter smaller than the axial length. The endomicroscope can acquire images of a surface of a hollow organ, and includes a microscopic image acquisition assembly having an optical axis oriented in a radial direction of the endomicroscope to acquire microscopic images of a section of the surface of a hollow organ present in a predetermined image acquisition area on a radial outer surface of the endomicroscope through a housing of the endomicroscope that has sectionally light-transparent material. A light source emits light rays in a radial direction through the light-transparent material of the housing during image acquisition. The light source and the light-transparent material of the housing located between the light source and the predetermined image acquisition area are interconnected to each other such that no refraction interface exists between the light source and the image acquisition area.

Abstract: The present invention relates to a device, system and method for skin detection. To enable a reliable, accurate and fast detection the proposed device comprises an input interface (30) for obtaining image data of a scene, said image data comprising a time sequence of image frames, an extraction unit (31) for extracting a photoplethysmography (PPG) signal from a region of interest of said image data, a transformation unit (32) for transforming said PPG signal into a spectral signal, a sorting unit (33) for sorting said spectral signal to obtain a sorted spectral signal representing a descriptor, and a classifier (34) for classifying said region of interest as skin region of a living being or as non-skin region based on the descriptor.

Abstract: The invention presents methods of using Fourier transform infrared (FTIR) microspectroscopy for common and specific characterization of carcinogenesis in human skin tumors. The invention provides the user with the method to analyse intra- and inter-molecular interactions for nucleic acids and proteins expressed in infrared (IR) spectra of human skin epidermal cancers towards understanding the molecular, cellular and tissue changes that occur during skin carcinogenesis. More particularly, presented analytical method has the advantage to simultaneously observe DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions by means of their expressed interacting activity levels within one type of tumour and between different types of tumours, both commonly and specifically, with further indication of the grade of activity in benign, premalignant and malignant skin tissue cells.

Abstract: The present invention relates to a multichannel head assembly for a three-dimensional modeling apparatus which can improve productivity by simultaneously or synchronously modeling a plurality of three-dimensional shaped objects having the same shape or different shapes, and a three-dimensional modeling apparatus using the same, the present invention comprising: a modeling light source unit for allowing N modeling beams to be incident to a light guide unit; the light guide unit for receiving the N incident modeling beams and having a function of guiding each of the N modeling beams along a predetermined path so as to allow the N modeling beams to be incident to N modeling planes in one-to-one correspondence with each other; and a control unit for controlling driving of the modeling light source unit and driving of the light guide unit to be linked with each other.

Abstract: The present invention relates to a method for detection in IR (infrared) spectra of human epidermal skin tissue the presence of the multiplet around 1055 cm?1, i.e. the ratio of intensity of the nucleic acids bands, DNA and RNA, indicative for prognosis, diagnosis and prediction of epidermal skin cancers and precancers. Detection of the multiplet together with patterned appearance of DNA/RNA triad peaks at about 1071, 1084/1085 and 1095 cm?1 additionally indicates relation to certain types of tumour and malignancy, also indicating progression of malignancy and progression towards malignancy.

Abstract: Embodiments of the present disclosure disclose a method and apparatus for acquiring information. A specific embodiment of the method includes: acquiring a fundus image; introducing the fundus image into a pre-trained disease grading model to obtain disease grading information, the disease grading model being used for extracting characteristic information from a lesion image included in the fundus image, and generating disease grading information based on the extracted characteristic information, the disease grading information including grade information of a disease, a lesion type, a lesion location, and a number of lesions included by the disease; and constructing output information using the disease grading information. This embodiment improves the accuracy of grading information.

Abstract: A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a fiber array, a detector, and a computing device. The fiber array includes a plurality of fibers configured to transport resultant light received by the head apparatus. The detector includes a plurality of super-pixels each defined by a plurality of pixels of an array of pixels. Each super-pixel is associated with a fiber. Each super-pixel is configured to generate a plurality of detection signals in response to detected resultant light from its associated fiber. The computing device receives the detection signals from each of the plurality of super-pixels. The computing device generates a high density-diffuse optical tomography (HD-DOT) image signal of the brain activity of the subject based on the detection signals from the super-pixels.

Abstract: An imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, a camera having one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light are switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.

Abstract: Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval.

Abstract: A movement assessing method and a movement assessing system are provided. The movement assessing method includes the following steps. At least one limb angle is obtained. A limb position accuracy is analyzed according to the limb angle. A center of gravity is obtained. A balance accuracy is analyzed according to the center of gravity. A movement index is calculated via a limb weight and a balance weight according to at least the limb position accuracy and the balance accuracy.

Abstract: The present disclosure includes a processing device, a method, and a non-transitory computer-readable medium. The processing device includes circuitry configured to acquire a plurality of images captured in a time series by an image sensor, each of the plurality of images is based on light in one of a plurality of predetermined polarization directions and in one of a plurality of predetermined wavelength bands. The circuitry is further configured to stitch together at least a part of the plurality of images corresponding to a single polarization direction and a single predetermined wavelength band from the plurality of predetermined wavelength bands to generate a composite image.

Abstract: Disclosed are apparatus and methods for determining accurate optical property values of turbid media. In one embodiment, the method includes (a) providing a light source, having a first wavelength and a known illumination power, sequentially at a plurality of specific illumination positions on a first surface of the specimen; (b) for each specific position of the light source, obtaining light emission measurements from a second surface of the specimen that is opposite the first surface, wherein the light emission measurements are obtained for a plurality of surface positions of the second surface; and (c) for each specific illumination position of the light source at the first surface of the specimen, determining one or more optical properties for the specimen based on the specific illumination position of the light source, the first wavelength of the light source, the known illumination power of the light source, and the obtained light emission measurements for such each specific illumination position.

Abstract: Methods and apparatuses for heart rate detection are described. In one example, a headphones apparatus and method includes emitting a first light in a first light direction directed at a left ear location from a left ear light emitter, and detecting a detected first light at a left ear light detector following interaction of the first light with a left ear tissue. The method includes emitting a second light in a second light direction directed at a right ear location from a right ear light emitter, the right ear location different from the left ear location. The method further includes detecting a detected second light at a right ear light detector following interaction of the second light with a right ear tissue, and estimating a heart rate from the detected first light and the detected second light.

Abstract: A computer-implemented method for routing a food product using an image of the food product, according to one embodiment, includes receiving an image of a food product, receiving an environmental condition on or near the food product, evaluating the food product using the image and the environmental condition, and determining a delivery destination for the food product based at least in part on the evaluation of the food product.

Abstract: A light-guiding earpiece configured to be worn by a subject includes a base comprising a speaker and at least one optical detector, a housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a flexible optical emitter configured to be conformable to at least a portion of the earpiece. The housing encloses the speaker and comprises at least one aperture through which sound from the speaker can pass. The flexible optical emitter may be integrally formed within the housing, and the housing may include translucent material that forms a light-guiding region through which light from the flexible optical emitter can pass. The optical detector may be a flexible optical detector.

Abstract: A medical device such as an oximeter includes a marking feature. In an implementation, a marking mechanism of the device marks tissue based on a location of where a measurement was taken by the device. In an implementation, the marking mechanism of the device marks tissue based on an oxygen saturation measurement obtained by the device.

Abstract: An apparatus for verifying repeatability of a spectroscope may verify repeatability of spectrum data, measured by a spectroscope, based on repeatability verification criteria, and control the spectroscope whether or not to remeasure spectrum data.

Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.

Abstract: A wound assessment method which can estimate a moisture level of the wound, and related image capture device. The wound area is imaged at least twice where the wound is illuminated under different illumination light intensities. The first image captured using a relatively low illumination light intensity is analyzed to assess the wound, for example measuring its size, color and texture. The second image captures using a relatively high illumination light intensity (e.g. using a flash) is analyzed to estimate the moisture level of the wound. The moisture level estimation method extracts white connected components from the second image, and estimates the moisture level based on the number, sizes, and centroid distribution of the white connected components. A 3D image of the wound may also be captured, e.g. using a structured-light 3D scanner of the image capture device.

Abstract: A device may include a housing, a light-permeable electrode, a computing device, and a display or other light-processing element. The display or other light-processing element may be positioned at least partly within the housing. The device components may be arranged to permit passage of light through the light-permeable electrode and relative to the light-processing element. The computing device may utilize electrical activity signal information from the light-permeable electrode to determine electrocardiogram (ECG) information or other information about the body of a user of the device. For example, the computing device may cause such ECG information to be projected through the light-permeable electrode by the display or other light-processing device and/or obtain additional information based on light received through the light-permeable electrode by the display or other light-processing device.

Abstract: A medical instrument is provided and includes a housing and a shaft coupled to the housing. The shaft has a proximal end and a distal end. An end-effector assembly is disposed at the distal end of the shaft. The end-effector assembly includes first and second jaw members. At least one of the first and second jaw members is movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween. The medical instrument also includes one or more light-emitting elements and one or more light-detecting elements configured to generate one or more signals indicative of tissue florescence. The one or more light-emitting elements are adapted to deliver light energy to tissue grasped between the first and second jaw members.

Abstract: A cover is configured to be removably attached to and at least partially cover a hearing aid earpiece. The removable cover includes light transmissive material in at least one portion thereof that is configured to guide light from at least one optical emitter associated with the hearing aid earpiece to a region of a body of a subject wearing the hearing aid earpiece and/or guide light from the body of the subject to at least one optical detector associated with the hearing aid earpiece. The removable cover may include at least one alignment member that facilitates stability of the hearing aid earpiece when inserted within an ear of the subject. The removable cover may include at least one lens region, at least one light diffusion region, and/or at least one luminescence region in optical communication with the light transmissive material.

Abstract: Systems and methods for guiding a surgical procedure based on a surgical procedure plan may include an image capture device that captures one or more images of an exposed anatomical feature of a patient. These systems and methods may also include a computing device configured to receive a surgical procedure plan based on one or more desired attributes related to an anatomical 3D model representing the exposed anatomical feature of the patient. The computing device may register the anatomical 3D model to the exposed anatomical feature of the patient based on the one or more images of the exposed anatomical feature and a projector may further provide surgical guidance information to a surgeon based on the surgical procedure plan to facilitate performance of the surgical procedure.

Abstract: An end effector is provided for connecting to a positioning arm of a positioning device of a medical navigation system. The end effector comprises a mating component for connecting to an output flange of the positioning arm, a handle portion having a first end and a second end, the first end extending from the mating component, the handle portion including a cable cut-out at the first end, and a camera mount connected to the second end of the handle portion.

Abstract: A mechanism is described for facilitating smart monitoring of body dimensions according to one embodiment. A method of embodiments, as described herein, includes receiving a first request to take a first picture of a user, wherein the first picture is taken at a first point in time using a depth-sensing camera; automatically computing first body dimensions relating to a body of the user based on at least one of a first image of the body and first depth information relating to one or more parts of the body, wherein the first image and the first depth information are obtained from the first picture; generate a first three-dimensional (3D) model of the body based on the first body dimensions; and communicating at least one of the first 3D model and the first body dimensions to a display device, wherein the display device to display at least one of the first 3D model and the first body dimensions.

Abstract: Methods and apparatus are described herein for fluorescent imaging of a retina using a head-mountable device. The retina is illuminated by a head-mountable device (HMD) with light at an excitation wavelength of a fluorophore in the retina and imaged by the HMD at an emission wavelength of the fluorophore. The direction of gaze of a user of the HMD could be determined from the retinal image. The pattern of vasculature in the retinal image could be used to identify the user of the HMD. Information in the retinal image could be used to determine the medical state of the user and diagnose disease states. Fluorescent agents can be introduced into the vasculature of the wearer of the HMD to facilitate these or other applications of fluorescent imaging of the retina using the HMD.

Abstract: A system and method for generating augmented segmented image set obtain are provided. The method may include: obtaining a first image including a first anatomical structure of a first object; determining first feature data of the first anatomical structure; determining one or more first transformations related to the first anatomical structure, wherein a first transformation includes a transformation type and one or more transformation parameters related to the transformation type; applying the one or more first transformations to the first feature data of the first anatomical structure to generate second feature data of the first anatomical structure; and generating a second image based on the second feature data of the first anatomical structure.

Abstract: A medical registration training component executing within a medical registration system performs a training medical registration operation on a pair of medical studies. Responsive to the medical registration training system determining that the training medical registration operation succeeds, the medical registration training system records a medical registration instance for the pair of medical studies in a medical registration history and marks the medical registration instance as a positive instance in the medical registration history. Responsive to the medical registration training system determining that the training medical registration operation requires correction, the medical registration training system records a medical registration instance for the pair of medical studies in the medical registration history and marks the medical registration instance as a negative instance in the medical registration history.

Abstract: An instrument monitoring apparatus includes a guide and sensing component configured to be attached to an ultrasound probe. The guide and sensing component includes a source of illumination configured to project a light beam into a light plane; and a light receiver aligned with the light plane and configured to quantify an amount of light reflected from an object in the light plane to the light receiver by receiving the amount of reflected light and converting it to an electrical signal. A control component includes a processor configured to receive the electrical signal from the light receiver, and based on a magnitude of the amount of light represented by the electrical signal, determine whether the object is sufficiently within the light plane. The processor instructs output of a first signal when it is determined that the object is sufficiently within the light plane.

Abstract: System and method for improving the shaving experience by providing improved visibility of the skin shaving area. A digital camera is integrated with the electric shaver for close image capturing of shaving area, and displaying it on a display unit. The display unit can be integral part of the electric shaver casing, or housed in a separated device which receives the image via a communication channel. The communication channel can be wireless (using radio, audio or light) or wired, such as dedicated cabling or using powerline communication. A light source is used to better illuminate the shaving area. Video compression and digital image processing techniques are used for providing for improved shaving results. The wired communication medium can simultaneously be used also for carrying power from the electric shaver assembly to the display unit, or from the display unit to the electric shaver.

Abstract: A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).

Abstract: A light emitting device includes a fluorescent material, a first laser element and a second laser element. The first laser element is configured to emit a first laser light to excite the fluorescent material. The first laser light having a first peak wavelength that is shorter than an excitation peak wavelength of the fluorescent material. The second laser element is configured to emit a second laser light to excite the fluorescent material. The second laser light has a second peak wavelength that is longer than the excitation peak wavelength of the fluorescent material.

Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Abstract: The present disclosure relates to systems and methods for positioning an X-ray scanner. The systems may perform the methods to obtain one or more images relating to the target in the object; determine one or more image target locations corresponding to the target based on the one or more images; determine a target position of the target based on the one or more image target locations corresponding to the target; and determine positioning information of an indicator or an X-ray source of the X-ray scanner based on the target position.

Abstract: A method for assessing healing of a subject includes receiving a time series of signal intensity data capturing the transit of an imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region; determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region; and converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map.

Abstract: An ophthalmic laser system includes a laser engine to generate a beam of femtosecond laser pulses, a laser scanner to scan each laser pulse of the beam in three dimensions according to a scan pattern, and a compound lens comprising a glass lens and a birefringent lens, the compound lens arranged to receive the scanned beam and configured to split each laser pulse of the scanned beam into an ordinary pulse and an extraordinary pulse, producing an ordinary beam comprising ordinary pulses and an extraordinary beam comprising extraordinary pulses. A particular ordinary pulse and a particular extraordinary pulse split from a particular laser pulse are spatially separated in depth along an optical axis of the compound lens, by a distance greater than or equal to 5 ?m, and temporally separated by a delay greater than or equal to a pulse duration of the femtosecond laser pulses. An objective is configured to focus the ordinary beam and the extraordinary beam within an ophthalmic target.

Abstract: A pulse wave measuring apparatus is provided, the pulse wave measuring apparatus including: a cardiac pulse waveform information acquiring unit that optically acquires cardiac pulse waveform information from a region of a living body; and a pulse wave feature amount calculating unit that calculates a pulse wave feature amount based on the pulse waveform information, wherein the pulse waveform information acquiring unit has a video input unit that receives an input of a video of the region of the living body, and the pulse waveform information acquiring unit outputs a window signal that includes first sample data from the pulse waveform information, and outputs, from the video, the window signal whose sampling rate is fixed to a predetermined rate based on a reference signal indicating time.

Abstract: Medical imaging camera head devices and methods are provided using light captured by an endoscope system or other medical scope or borescope. Afocal light from the scope is manipulated and split. The resulting first and second beams are passed through focusing optics to a single sensor. To take better advantage of the available number image sensor pixels, the beam may pass through lens elements (or prisms) to generate an anamorphic aspect ratio prior to being split, increasing the resolution of the image in one dimension. The afocal anamorphic beam is then split, and both images are focused on the image sensor. The anamorphism is compensated for in image processing, permitting higher resolution in one dimension along the image sensor. The manipulation of the beams prior to being split (and in some cases after or while being split) can take several forms, each offering distinct advantages over existing systems.

Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

Abstract: Devices and methods for profiling microbiota of skin are described which include a microbe profiling device including a device head and a hand-held housing, the device head including an epidermis-engaging component and an access window and configured to dislodge microbes from a skin surface, and the hand-held housing defining an opening aligned with the access window, the hand-held housing including a motor operably coupled to a motivatable component, a substrate disposed in relation to the motivatable component and including a microbe-capture region, a location-capture component to detect a location of one or more regions of the skin surface as the epidermis-engaging component contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the microbe-capture region, and a computing component including circuitry to associate the location of said one or more regions of the skin surface and the detected one or more signals.

Abstract: A sensor insertion device includes: a housing; a needle member comprising a needle portion configured to be inserted in the living body with a sensor and to be movable in the housing in an insertion direction and a pulling-out direction; a first urging member configured to urge the needle member in the insertion direction to move the needle member to a first position; a second urging member configured to urge the needle member in the pulling-out direction to move the needle member that has reached the first position to a second position; and a switching mechanism configured to perform selective switching from movement of the needle member by an urging force of the first urging member to movement of the needle member by an urging force of the second urging member when the needle member reaches the first position.

Abstract: In a biophotonic measurement device based on the principles of near-infrared spectroscopy (NIRS), in order to realize appropriate conditions in any light-source/detector arrangement and various required specifications, a photoirradiation module 13 including a light source 101, a photodetection module 14 including a photodetector 102, and a central control/analysis unit 18 are provided. The central control/analysis unit 18 acquires correspondence relations between each of photodetection units and photoirradiation units by using a correspondence acquiring unit 19. The photoirradiation module 13 and the photodetection module 14 switch signal detection methods at each measurement point by utilizing an evaluation function value determined by detection output of the photodetector 102 so that the plurality of signal detection methods are mixable, and the high-precision and optimum biophotonic measurement device is realized.

Abstract: A dermatoscope device is provided. The dermatoscope device includes an optical tube structure including an optical unit, which is provided to allow an observer to enlarge and inspect an observation target, and a light emitting unit which irradiates light to the observation target to be enlarged and inspected through the optical unit, a control module to control a form of irradiating the light through the optical unit, and a housing having the optical tube structure and the control module embedded therein.

Abstract: An example imaging system may include a spatial light modulator and a coherent optical receiver. The spatial light modulator may be configured to receive an optical input wave and perform wavefront shaping on the optical input wave to output a shaped wave. The coherent optical receiver may include an optical local oscillator, an optical beam splitter, an optical detector, and processing circuitry. The optical detector may be configured to receive a mixed wave from the optical beam splitter that is based on the mixing of a local oscillator wave with a scattering medium output wave that at least initially comprises a speckle pattern formed by the shaped wave interacting with a scattering medium. The processing circuitry may be configured to perform coherent detection on the mixed wave to extract optical amplitude and phase information, and provide an error signal as feedback to the spatial light modulator for performing iterative wavefront shaping.

Abstract: A portable vein viewer apparatus may be battery powered and hand-held to reveal patient vasculature information to aid in venipuncture processes. The apparatus comprises a first laser diode emitting infrared light, and a second laser diode emitting only visible wavelengths, wherein vasculature absorbs a portion of the infrared light causing reflection of a contrasted infrared image. A pair of silicon PIN photodiodes, responsive to the contrasted infrared image, causes transmission of a corresponding signal. The signal is processed through circuitry to amplify, sum, and filter the outputted signals, and with the use of an image processing algorithm, the contrasted image is projected onto the patient's skin surface using the second laser diode. Revealed information may comprise vein location, depth, diameter, and degree of certainty of vein locations. Projection of vein images may be a positive or a negative image. Venipuncture needles may be coated to provide visibility in projected images.

Abstract: Materials and methods are disclosed for screening advanced glycation end-products from the mammalian ocular lens proteins to quantify early biomarkers for the diagnosis of diabetes mellitus and related complications.

Abstract: A reflectometry instrument includes a light source for emitting an illumination beam that illuminates the macula. A portion of the illumination beam is reflected from the macula and forms a detection beam. The detection beam is indicative of macular pigment in the macula. The instrument also includes a first mirror for reflecting the illumination beam toward the macula and for reflecting the detection beam from the macula. The instrument is configured so that the illumination beam and the detection beam remain separated between the macula and the first mirror.