Visible Light Radiation Patents (Class 600/476)
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Patent number: 10809187Abstract: The invention presents methods of using Fourier transform infrared (FTIR) microspectroscopy for common and specific characterization of carcinogenesis in human skin tumors. The invention provides the user with the method to analyse intra- and inter-molecular interactions for nucleic acids and proteins expressed in infrared (IR) spectra of human skin epidermal cancers towards understanding the molecular, cellular and tissue changes that occur during skin carcinogenesis. More particularly, presented analytical method has the advantage to simultaneously observe DNA-RNA, DNA-DNA, DNA-protein and protein-protein interactions by means of their expressed interacting activity levels within one type of tumour and between different types of tumours, both commonly and specifically, with further indication of the grade of activity in benign, premalignant and malignant skin tissue cells.Type: GrantFiled: February 21, 2013Date of Patent: October 20, 2020Inventor: Natalja Eikje
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Patent number: 10810788Abstract: The present invention relates to a multichannel head assembly for a three-dimensional modeling apparatus which can improve productivity by simultaneously or synchronously modeling a plurality of three-dimensional shaped objects having the same shape or different shapes, and a three-dimensional modeling apparatus using the same, the present invention comprising: a modeling light source unit for allowing N modeling beams to be incident to a light guide unit; the light guide unit for receiving the N incident modeling beams and having a function of guiding each of the N modeling beams along a predetermined path so as to allow the N modeling beams to be incident to N modeling planes in one-to-one correspondence with each other; and a control unit for controlling driving of the modeling light source unit and driving of the light guide unit to be linked with each other.Type: GrantFiled: October 28, 2015Date of Patent: October 20, 2020Assignee: Korea Institute of Industrial TechnologyInventors: Seung Taek Kim, Jong Seok Kim, Hyung Tae Kim, Kyung Chan Jin, Moon Soo Park
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Patent number: 10801952Abstract: The present invention relates to a method for detection in IR (infrared) spectra of human epidermal skin tissue the presence of the multiplet around 1055 cm?1, i.e. the ratio of intensity of the nucleic acids bands, DNA and RNA, indicative for prognosis, diagnosis and prediction of epidermal skin cancers and precancers. Detection of the multiplet together with patterned appearance of DNA/RNA triad peaks at about 1071, 1084/1085 and 1095 cm?1 additionally indicates relation to certain types of tumour and malignancy, also indicating progression of malignancy and progression towards malignancy.Type: GrantFiled: March 23, 2013Date of Patent: October 13, 2020Inventor: Natalja Eikje
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Patent number: 10803584Abstract: Embodiments of the present disclosure disclose a method and apparatus for acquiring information. A specific embodiment of the method includes: acquiring a fundus image; introducing the fundus image into a pre-trained disease grading model to obtain disease grading information, the disease grading model being used for extracting characteristic information from a lesion image included in the fundus image, and generating disease grading information based on the extracted characteristic information, the disease grading information including grade information of a disease, a lesion type, a lesion location, and a number of lesions included by the disease; and constructing output information using the disease grading information. This embodiment improves the accuracy of grading information.Type: GrantFiled: September 13, 2018Date of Patent: October 13, 2020Assignee: Baidu Online Network Technology (Beijing) Co., Ltd.Inventors: Shaoting Zhang, Weidong Zhang, Qi Duan
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Patent number: 10786156Abstract: A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a fiber array, a detector, and a computing device. The fiber array includes a plurality of fibers configured to transport resultant light received by the head apparatus. The detector includes a plurality of super-pixels each defined by a plurality of pixels of an array of pixels. Each super-pixel is associated with a fiber. Each super-pixel is configured to generate a plurality of detection signals in response to detected resultant light from its associated fiber. The computing device receives the detection signals from each of the plurality of super-pixels. The computing device generates a high density-diffuse optical tomography (HD-DOT) image signal of the brain activity of the subject based on the detection signals from the super-pixels.Type: GrantFiled: October 16, 2015Date of Patent: September 29, 2020Assignee: Washington UniversityInventors: Joseph P. Culver, Karla Bergonzi, Adam Eggebrecht, Silvina Ferradal
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Patent number: 10779734Abstract: An imaging system for acquisition of NIR and full-color images includes a light source providing visible light and NIR light to an area under observation, such as living tissue, a camera having one or more image sensors configured to separately detect blue reflectance light, green reflectance light, and combined red reflectance light/detected NIR light returned from the area under observation. A controller in signal communication with the light source and the camera is configured to control the light source to continuously illuminate area under observation with temporally continuous blue/green illumination light and with red illumination light and NIR excitation light. At least one of the red illumination light and NIR excitation light are switched on and off periodically in synchronism with the acquisition of red and NIR light images in the camera.Type: GrantFiled: May 2, 2017Date of Patent: September 22, 2020Assignee: Stryker European Operations LimitedInventors: John Fengler, Paul R. Westwick, Aurther E. Bailey, Paul Cottle
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Patent number: 10783632Abstract: Machine learning systems and methods are disclosed for prediction of wound healing, such as for diabetic foot ulcers or other wounds, and for assessment implementations such as segmentation of images into wound regions and non-wound regions. Systems for assessing or predicting wound healing can include a light detection element configured to collect light of at least a first wavelength reflected from a tissue region including a wound, and one or more processors configured to generate an image based on a signal from the light detection element having pixels depicting the tissue region, determine reflectance intensity values for at least a subset of the pixels, determine one or more quantitative features of the subset of the plurality of pixels based on the reflectance intensity values, and generate a predicted or assessed healing parameter associated with the wound over a predetermined time interval.Type: GrantFiled: January 9, 2020Date of Patent: September 22, 2020Assignee: SPECTRAL MD, INC.Inventors: Wensheng Fan, John Michael DiMaio, Jeffrey E. Thatcher, Peiran Quan, Faliu Yi, Kevin Plant, Ronald Baxter, Brian McCall, Zhicun Gao, Jason Dwight
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Patent number: 10779772Abstract: A movement assessing method and a movement assessing system are provided. The movement assessing method includes the following steps. At least one limb angle is obtained. A limb position accuracy is analyzed according to the limb angle. A center of gravity is obtained. A balance accuracy is analyzed according to the center of gravity. A movement index is calculated via a limb weight and a balance weight according to at least the limb position accuracy and the balance accuracy.Type: GrantFiled: November 3, 2017Date of Patent: September 22, 2020Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Hsin-Hung Pan, Jung-Hao Wang, Guan-Ting Chen, Yao-Hsien Huang, Hsien-Te Peng
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Patent number: 10776901Abstract: The present disclosure includes a processing device, a method, and a non-transitory computer-readable medium. The processing device includes circuitry configured to acquire a plurality of images captured in a time series by an image sensor, each of the plurality of images is based on light in one of a plurality of predetermined polarization directions and in one of a plurality of predetermined wavelength bands. The circuitry is further configured to stitch together at least a part of the plurality of images corresponding to a single polarization direction and a single predetermined wavelength band from the plurality of predetermined wavelength bands to generate a composite image.Type: GrantFiled: August 3, 2017Date of Patent: September 15, 2020Assignee: Sony CorporationInventors: Hitoshi Mitani, Masafumi Wakazono
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Patent number: 10775308Abstract: Disclosed are apparatus and methods for determining accurate optical property values of turbid media. In one embodiment, the method includes (a) providing a light source, having a first wavelength and a known illumination power, sequentially at a plurality of specific illumination positions on a first surface of the specimen; (b) for each specific position of the light source, obtaining light emission measurements from a second surface of the specimen that is opposite the first surface, wherein the light emission measurements are obtained for a plurality of surface positions of the second surface; and (c) for each specific illumination position of the light source at the first surface of the specimen, determining one or more optical properties for the specimen based on the specific illumination position of the light source, the first wavelength of the light source, the known illumination power of the light source, and the obtained light emission measurements for such each specific illumination position.Type: GrantFiled: August 24, 2007Date of Patent: September 15, 2020Assignee: Xenogen CorporationInventors: Daniel G. Stearns, Bradley W. Rice
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Patent number: 10772517Abstract: Methods and apparatuses for heart rate detection are described. In one example, a headphones apparatus and method includes emitting a first light in a first light direction directed at a left ear location from a left ear light emitter, and detecting a detected first light at a left ear light detector following interaction of the first light with a left ear tissue. The method includes emitting a second light in a second light direction directed at a right ear location from a right ear light emitter, the right ear location different from the left ear location. The method further includes detecting a detected second light at a right ear light detector following interaction of the second light with a right ear tissue, and estimating a heart rate from the detected first light and the detected second light.Type: GrantFiled: July 27, 2017Date of Patent: September 15, 2020Assignee: Plantronics, Inc.Inventor: Jacobus Cornelis Haartsen
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Patent number: 10755137Abstract: A computer-implemented method for routing a food product using an image of the food product, according to one embodiment, includes receiving an image of a food product, receiving an environmental condition on or near the food product, evaluating the food product using the image and the environmental condition, and determining a delivery destination for the food product based at least in part on the evaluation of the food product.Type: GrantFiled: March 22, 2019Date of Patent: August 25, 2020Assignee: Zest Labs, Inc.Inventors: Peter A. Mehring, Thomas C. Reese
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Patent number: 10750954Abstract: A light-guiding earpiece configured to be worn by a subject includes a base comprising a speaker and at least one optical detector, a housing extending outwardly from the base that is configured to be positioned within an ear of a subject, and a flexible optical emitter configured to be conformable to at least a portion of the earpiece. The housing encloses the speaker and comprises at least one aperture through which sound from the speaker can pass. The flexible optical emitter may be integrally formed within the housing, and the housing may include translucent material that forms a light-guiding region through which light from the flexible optical emitter can pass. The optical detector may be a flexible optical detector.Type: GrantFiled: June 28, 2018Date of Patent: August 25, 2020Assignee: Valencell, Inc.Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
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Patent number: 10751144Abstract: A medical device such as an oximeter includes a marking feature. In an implementation, a marking mechanism of the device marks tissue based on a location of where a measurement was taken by the device. In an implementation, the marking mechanism of the device marks tissue based on an oxygen saturation measurement obtained by the device.Type: GrantFiled: February 23, 2018Date of Patent: August 25, 2020Assignee: ViOptix, Inc.Inventors: Larry C. Heaton, II, Robert E. Lash
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Patent number: 10746597Abstract: An apparatus for verifying repeatability of a spectroscope may verify repeatability of spectrum data, measured by a spectroscope, based on repeatability verification criteria, and control the spectroscope whether or not to remeasure spectrum data.Type: GrantFiled: July 20, 2016Date of Patent: August 18, 2020Assignee: SAMSUNG ELECTRONICS CO., LTD.Inventors: So Young Lee, Sang Kyu Kim, Kun Sun Eom, Joon Hyung Lee
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Patent number: 10736512Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.Type: GrantFiled: February 13, 2015Date of Patent: August 11, 2020Assignee: The George Washington UniversityInventors: Marco A. Mercader, Matthew W. Kay, Narine Sarvazyan
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Patent number: 10742962Abstract: A wound assessment method which can estimate a moisture level of the wound, and related image capture device. The wound area is imaged at least twice where the wound is illuminated under different illumination light intensities. The first image captured using a relatively low illumination light intensity is analyzed to assess the wound, for example measuring its size, color and texture. The second image captures using a relatively high illumination light intensity (e.g. using a flash) is analyzed to estimate the moisture level of the wound. The moisture level estimation method extracts white connected components from the second image, and estimates the moisture level based on the number, sizes, and centroid distribution of the white connected components. A 3D image of the wound may also be captured, e.g. using a structured-light 3D scanner of the image capture device.Type: GrantFiled: January 15, 2019Date of Patent: August 11, 2020Assignee: KONICA MINOLTA LABORATORY U.S.A., INC.Inventors: Wei Ming, Xiaonong Zhan, Taisuke Akahori
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Patent number: 10729347Abstract: A device may include a housing, a light-permeable electrode, a computing device, and a display or other light-processing element. The display or other light-processing element may be positioned at least partly within the housing. The device components may be arranged to permit passage of light through the light-permeable electrode and relative to the light-processing element. The computing device may utilize electrical activity signal information from the light-permeable electrode to determine electrocardiogram (ECG) information or other information about the body of a user of the device. For example, the computing device may cause such ECG information to be projected through the light-permeable electrode by the display or other light-processing device and/or obtain additional information based on light received through the light-permeable electrode by the display or other light-processing device.Type: GrantFiled: January 31, 2018Date of Patent: August 4, 2020Assignee: Verily Life Sciences LLCInventor: Brett Schleicher
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Patent number: 10722292Abstract: A medical instrument is provided and includes a housing and a shaft coupled to the housing. The shaft has a proximal end and a distal end. An end-effector assembly is disposed at the distal end of the shaft. The end-effector assembly includes first and second jaw members. At least one of the first and second jaw members is movable from a first position wherein the first and second jaw members are disposed in spaced relation relative to one another to at least a second position closer to one another wherein the first and second jaw members cooperate to grasp tissue therebetween. The medical instrument also includes one or more light-emitting elements and one or more light-detecting elements configured to generate one or more signals indicative of tissue florescence. The one or more light-emitting elements are adapted to deliver light energy to tissue grasped between the first and second jaw members.Type: GrantFiled: June 2, 2014Date of Patent: July 28, 2020Assignee: Covidien LPInventors: Shobhit Arya, Lei Su, Vadzim Chalau, Kristy Lee Cloyd, Martin A. B. Hedegaard, Molly Stevens, Daniel S. Elson, George B. Hanna
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Patent number: 10716480Abstract: A cover is configured to be removably attached to and at least partially cover a hearing aid earpiece. The removable cover includes light transmissive material in at least one portion thereof that is configured to guide light from at least one optical emitter associated with the hearing aid earpiece to a region of a body of a subject wearing the hearing aid earpiece and/or guide light from the body of the subject to at least one optical detector associated with the hearing aid earpiece. The removable cover may include at least one alignment member that facilitates stability of the hearing aid earpiece when inserted within an ear of the subject. The removable cover may include at least one lens region, at least one light diffusion region, and/or at least one luminescence region in optical communication with the light transmissive material.Type: GrantFiled: June 13, 2018Date of Patent: July 21, 2020Assignee: Valencell, Inc.Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
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Patent number: 10716643Abstract: Systems and methods for guiding a surgical procedure based on a surgical procedure plan may include an image capture device that captures one or more images of an exposed anatomical feature of a patient. These systems and methods may also include a computing device configured to receive a surgical procedure plan based on one or more desired attributes related to an anatomical 3D model representing the exposed anatomical feature of the patient. The computing device may register the anatomical 3D model to the exposed anatomical feature of the patient based on the one or more images of the exposed anatomical feature and a projector may further provide surgical guidance information to a surgeon based on the surgical procedure plan to facilitate performance of the surgical procedure.Type: GrantFiled: May 7, 2018Date of Patent: July 21, 2020Assignee: ORBISMV LLCInventors: Daniel F. Justin, Ronald A. Tetenbaum, Jason M. Eichenholz, Eric J. Tetenbaum
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Patent number: 10709520Abstract: An end effector is provided for connecting to a positioning arm of a positioning device of a medical navigation system. The end effector comprises a mating component for connecting to an output flange of the positioning arm, a handle portion having a first end and a second end, the first end extending from the mating component, the handle portion including a cable cut-out at the first end, and a camera mount connected to the second end of the handle portion.Type: GrantFiled: July 25, 2018Date of Patent: July 14, 2020Assignee: Synaptive Medical (Barbados) Inc.Inventors: Brent Andrew Bailey, Mariana Garcia Coni
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Patent number: 10702745Abstract: A mechanism is described for facilitating smart monitoring of body dimensions according to one embodiment. A method of embodiments, as described herein, includes receiving a first request to take a first picture of a user, wherein the first picture is taken at a first point in time using a depth-sensing camera; automatically computing first body dimensions relating to a body of the user based on at least one of a first image of the body and first depth information relating to one or more parts of the body, wherein the first image and the first depth information are obtained from the first picture; generate a first three-dimensional (3D) model of the body based on the first body dimensions; and communicating at least one of the first 3D model and the first body dimensions to a display device, wherein the display device to display at least one of the first 3D model and the first body dimensions.Type: GrantFiled: January 30, 2018Date of Patent: July 7, 2020Assignee: INTEL CORPORATIONInventors: Venkata Siva Varun Kumar Nandimandalam, Jim Santiago Baca, Neal P. Smith, David W. Baker
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Patent number: 10682055Abstract: Methods and apparatus are described herein for fluorescent imaging of a retina using a head-mountable device. The retina is illuminated by a head-mountable device (HMD) with light at an excitation wavelength of a fluorophore in the retina and imaged by the HMD at an emission wavelength of the fluorophore. The direction of gaze of a user of the HMD could be determined from the retinal image. The pattern of vasculature in the retinal image could be used to identify the user of the HMD. Information in the retinal image could be used to determine the medical state of the user and diagnose disease states. Fluorescent agents can be introduced into the vasculature of the wearer of the HMD to facilitate these or other applications of fluorescent imaging of the retina using the HMD.Type: GrantFiled: March 9, 2018Date of Patent: June 16, 2020Assignee: Verily Life Sciences LLCInventors: Adrian Wong, Philipp Helmut Schmaelzle, Andrew Jason Conrad, Samuel D'Amico
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Patent number: 10685445Abstract: A system and method for generating augmented segmented image set obtain are provided. The method may include: obtaining a first image including a first anatomical structure of a first object; determining first feature data of the first anatomical structure; determining one or more first transformations related to the first anatomical structure, wherein a first transformation includes a transformation type and one or more transformation parameters related to the transformation type; applying the one or more first transformations to the first feature data of the first anatomical structure to generate second feature data of the first anatomical structure; and generating a second image based on the second feature data of the first anatomical structure.Type: GrantFiled: June 9, 2018Date of Patent: June 16, 2020Assignee: UIH-RT US LLCInventors: Supratik Bose, Jonathan Maltz
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Patent number: 10679325Abstract: A medical registration training component executing within a medical registration system performs a training medical registration operation on a pair of medical studies. Responsive to the medical registration training system determining that the training medical registration operation succeeds, the medical registration training system records a medical registration instance for the pair of medical studies in a medical registration history and marks the medical registration instance as a positive instance in the medical registration history. Responsive to the medical registration training system determining that the training medical registration operation requires correction, the medical registration training system records a medical registration instance for the pair of medical studies in the medical registration history and marks the medical registration instance as a negative instance in the medical registration history.Type: GrantFiled: September 16, 2019Date of Patent: June 9, 2020Assignee: International Business Machines CorporationInventors: Sun Young Park, Dustin M. Sargent
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Patent number: 10667789Abstract: An instrument monitoring apparatus includes a guide and sensing component configured to be attached to an ultrasound probe. The guide and sensing component includes a source of illumination configured to project a light beam into a light plane; and a light receiver aligned with the light plane and configured to quantify an amount of light reflected from an object in the light plane to the light receiver by receiving the amount of reflected light and converting it to an electrical signal. A control component includes a processor configured to receive the electrical signal from the light receiver, and based on a magnitude of the amount of light represented by the electrical signal, determine whether the object is sufficiently within the light plane. The processor instructs output of a first signal when it is determined that the object is sufficiently within the light plane.Type: GrantFiled: October 11, 2017Date of Patent: June 2, 2020Inventor: Geoffrey Steven Hastings
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Patent number: 10661458Abstract: System and method for improving the shaving experience by providing improved visibility of the skin shaving area. A digital camera is integrated with the electric shaver for close image capturing of shaving area, and displaying it on a display unit. The display unit can be integral part of the electric shaver casing, or housed in a separated device which receives the image via a communication channel. The communication channel can be wireless (using radio, audio or light) or wired, such as dedicated cabling or using powerline communication. A light source is used to better illuminate the shaving area. Video compression and digital image processing techniques are used for providing for improved shaving results. The wired communication medium can simultaneously be used also for carrying power from the electric shaver assembly to the display unit, or from the display unit to the electric shaver.Type: GrantFiled: September 9, 2019Date of Patent: May 26, 2020Assignee: May Patents Ltd.Inventor: Yehuda Binder
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Patent number: 10653346Abstract: A low cost portable high speed quantitative system for diffuse optical spectroscopic imaging of human tissue. The hybrid system (CWFD) can measure absolute optical properties from 660 nm to 980 nm and recover all tissue chromophore concentrations. The standalone FD module can be utilized to measure scattering at every measurement and recover deoxygenated and oxygenated hemoglobin concentrations. The CW module can operate concurrently with the FD module to also measure water and lipid. The high temporal resolution and large signal-to-noise ratio of the CWFD system may be used to explore tissue oximetry, vascular occlusion, and paced breathing models to measure and analyze tissue hemodynamics response to changes in blood flow. Continuous monitoring of vasculature response to various modified blood perfusion conditions can provide information about local tissue metabolism and physiological state (dysfunction).Type: GrantFiled: January 26, 2017Date of Patent: May 19, 2020Assignee: The Regents of the University of CaliforniaInventors: Soroush Mohammad Mirzaei Zarandi, Bruce J. Tromberg, Thomas D. O'Sullivan, Siavash Sedighzadeh Yazdi, Albert Cerussi
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Patent number: 10648911Abstract: A light emitting device includes a fluorescent material, a first laser element and a second laser element. The first laser element is configured to emit a first laser light to excite the fluorescent material. The first laser light having a first peak wavelength that is shorter than an excitation peak wavelength of the fluorescent material. The second laser element is configured to emit a second laser light to excite the fluorescent material. The second laser light has a second peak wavelength that is longer than the excitation peak wavelength of the fluorescent material.Type: GrantFiled: November 16, 2017Date of Patent: May 12, 2020Assignee: NICHIA CORPORATIONInventor: Toshiaki Yamashita
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Patent number: 10639012Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.Type: GrantFiled: September 19, 2016Date of Patent: May 5, 2020Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), FUNDACION PARA EL CONOCIMIENTO MADRI+D, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Luis Elvira Segura, Oscar Martinez Graullera, Shiva Kant Shukla, Francisco Montero, Javier Jimenez, Ian Richard Butterworth, Brian Anthony, John Lee Haeseon, Carlos Castro Gonzalez
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Patent number: 10638985Abstract: The present disclosure relates to systems and methods for positioning an X-ray scanner. The systems may perform the methods to obtain one or more images relating to the target in the object; determine one or more image target locations corresponding to the target based on the one or more images; determine a target position of the target based on the one or more image target locations corresponding to the target; and determine positioning information of an indicator or an X-ray source of the X-ray scanner based on the target position.Type: GrantFiled: June 13, 2017Date of Patent: May 5, 2020Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.Inventors: Qianqian Yu, Wenqiang Liu, Bing Tang, Shouyuan Jin
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Patent number: 10636144Abstract: A method for assessing healing of a subject includes receiving a time series of signal intensity data capturing the transit of an imaging agent through tissue over a period of time, wherein the tissue comprises a plurality of calculation regions and wherein signal intensity in each calculation region over the period of time may be approximated by a time-intensity curve corresponding to the calculation region; determining, for each calculation region, a coefficient value that is related to at least a portion of the time-intensity curve corresponding to the calculation region; and converting the coefficient values across the plurality of calculation regions into a coefficient-derived image map.Type: GrantFiled: June 3, 2019Date of Patent: April 28, 2020Assignee: Novadaq Technologies ULCInventor: Lina Gurevich
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Patent number: 10632014Abstract: An ophthalmic laser system includes a laser engine to generate a beam of femtosecond laser pulses, a laser scanner to scan each laser pulse of the beam in three dimensions according to a scan pattern, and a compound lens comprising a glass lens and a birefringent lens, the compound lens arranged to receive the scanned beam and configured to split each laser pulse of the scanned beam into an ordinary pulse and an extraordinary pulse, producing an ordinary beam comprising ordinary pulses and an extraordinary beam comprising extraordinary pulses. A particular ordinary pulse and a particular extraordinary pulse split from a particular laser pulse are spatially separated in depth along an optical axis of the compound lens, by a distance greater than or equal to 5 ?m, and temporally separated by a delay greater than or equal to a pulse duration of the femtosecond laser pulses. An objective is configured to focus the ordinary beam and the extraordinary beam within an ophthalmic target.Type: GrantFiled: June 8, 2018Date of Patent: April 28, 2020Assignee: Alcon Inc.Inventors: Zsolt Bor, Mikhail Ovchinnikov
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Patent number: 10624586Abstract: A pulse wave measuring apparatus is provided, the pulse wave measuring apparatus including: a cardiac pulse waveform information acquiring unit that optically acquires cardiac pulse waveform information from a region of a living body; and a pulse wave feature amount calculating unit that calculates a pulse wave feature amount based on the pulse waveform information, wherein the pulse waveform information acquiring unit has a video input unit that receives an input of a video of the region of the living body, and the pulse waveform information acquiring unit outputs a window signal that includes first sample data from the pulse waveform information, and outputs, from the video, the window signal whose sampling rate is fixed to a predetermined rate based on a reference signal indicating time.Type: GrantFiled: June 22, 2016Date of Patent: April 21, 2020Assignee: Asahi Kasei Kabushiki KaishaInventors: Yoshihiro Noguchi, Shimpei Ogawa, Masaya Yamashita, Akihiro Okamoto
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Patent number: 10606062Abstract: Medical imaging camera head devices and methods are provided using light captured by an endoscope system or other medical scope or borescope. Afocal light from the scope is manipulated and split. The resulting first and second beams are passed through focusing optics to a single sensor. To take better advantage of the available number image sensor pixels, the beam may pass through lens elements (or prisms) to generate an anamorphic aspect ratio prior to being split, increasing the resolution of the image in one dimension. The afocal anamorphic beam is then split, and both images are focused on the image sensor. The anamorphism is compensated for in image processing, permitting higher resolution in one dimension along the image sensor. The manipulation of the beams prior to being split (and in some cases after or while being split) can take several forms, each offering distinct advantages over existing systems.Type: GrantFiled: June 20, 2018Date of Patent: March 31, 2020Assignee: KARL STORZ Imaging, Inc.Inventors: George E. Duckett, III, Marios Kyperountas
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Patent number: 10596267Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.Type: GrantFiled: June 23, 2017Date of Patent: March 24, 2020Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear Infirmary, Massachusetts Institute of TechnologyInventors: Jeffrey T. Borenstein, Erin Pararas, Ernest S. Kim, Vishal Tandon, Andrew Ayoob, Michael McKenna, William Sewell, Marcello Peppi, Marc Weinberg, Robert Langer
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Patent number: 10575782Abstract: A sensor insertion device includes: a housing; a needle member comprising a needle portion configured to be inserted in the living body with a sensor and to be movable in the housing in an insertion direction and a pulling-out direction; a first urging member configured to urge the needle member in the insertion direction to move the needle member to a first position; a second urging member configured to urge the needle member in the pulling-out direction to move the needle member that has reached the first position to a second position; and a switching mechanism configured to perform selective switching from movement of the needle member by an urging force of the first urging member to movement of the needle member by an urging force of the second urging member when the needle member reaches the first position.Type: GrantFiled: July 26, 2017Date of Patent: March 3, 2020Assignee: TERUMO KABUSHIKI KAISHAInventors: Takeshi Tsubouchi, Eiji Arita
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Patent number: 10575834Abstract: Devices and methods for profiling microbiota of skin are described which include a microbe profiling device including a device head and a hand-held housing, the device head including an epidermis-engaging component and an access window and configured to dislodge microbes from a skin surface, and the hand-held housing defining an opening aligned with the access window, the hand-held housing including a motor operably coupled to a motivatable component, a substrate disposed in relation to the motivatable component and including a microbe-capture region, a location-capture component to detect a location of one or more regions of the skin surface as the epidermis-engaging component contacts said one or more regions, at least one sensor component to detect one or more signals emitted or reflected from the microbe-capture region, and a computing component including circuitry to associate the location of said one or more regions of the skin surface and the detected one or more signals.Type: GrantFiled: December 6, 2016Date of Patent: March 3, 2020Assignee: Elwha LLCInventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
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Patent number: 10548518Abstract: In a biophotonic measurement device based on the principles of near-infrared spectroscopy (NIRS), in order to realize appropriate conditions in any light-source/detector arrangement and various required specifications, a photoirradiation module 13 including a light source 101, a photodetection module 14 including a photodetector 102, and a central control/analysis unit 18 are provided. The central control/analysis unit 18 acquires correspondence relations between each of photodetection units and photoirradiation units by using a correspondence acquiring unit 19. The photoirradiation module 13 and the photodetection module 14 switch signal detection methods at each measurement point by utilizing an evaluation function value determined by detection output of the photodetector 102 so that the plurality of signal detection methods are mixable, and the high-precision and optimum biophotonic measurement device is realized.Type: GrantFiled: June 23, 2014Date of Patent: February 4, 2020Assignee: Hitachi, Ltd.Inventors: Tsukasa Funane, Takusige Katura, Hirokazu Atsumori, Masashi Kiguchi
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Patent number: 10537248Abstract: A dermatoscope device is provided. The dermatoscope device includes an optical tube structure including an optical unit, which is provided to allow an observer to enlarge and inspect an observation target, and a light emitting unit which irradiates light to the observation target to be enlarged and inspected through the optical unit, a control module to control a form of irradiating the light through the optical unit, and a housing having the optical tube structure and the control module embedded therein.Type: GrantFiled: July 3, 2018Date of Patent: January 21, 2020Assignee: ILLUCO CO., LTD.Inventor: Jin Hyeok Hong
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Patent number: 10541756Abstract: An example imaging system may include a spatial light modulator and a coherent optical receiver. The spatial light modulator may be configured to receive an optical input wave and perform wavefront shaping on the optical input wave to output a shaped wave. The coherent optical receiver may include an optical local oscillator, an optical beam splitter, an optical detector, and processing circuitry. The optical detector may be configured to receive a mixed wave from the optical beam splitter that is based on the mixing of a local oscillator wave with a scattering medium output wave that at least initially comprises a speckle pattern formed by the shaped wave interacting with a scattering medium. The processing circuitry may be configured to perform coherent detection on the mixed wave to extract optical amplitude and phase information, and provide an error signal as feedback to the spatial light modulator for performing iterative wavefront shaping.Type: GrantFiled: December 5, 2018Date of Patent: January 21, 2020Assignee: The Johns Hopkins UniversityInventors: Scott M. Hendrickson, David W. Blodgett, Clare W. Lau, Jeremiah J. Wathen
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Patent number: 10518046Abstract: A portable vein viewer apparatus may be battery powered and hand-held to reveal patient vasculature information to aid in venipuncture processes. The apparatus comprises a first laser diode emitting infrared light, and a second laser diode emitting only visible wavelengths, wherein vasculature absorbs a portion of the infrared light causing reflection of a contrasted infrared image. A pair of silicon PIN photodiodes, responsive to the contrasted infrared image, causes transmission of a corresponding signal. The signal is processed through circuitry to amplify, sum, and filter the outputted signals, and with the use of an image processing algorithm, the contrasted image is projected onto the patient's skin surface using the second laser diode. Revealed information may comprise vein location, depth, diameter, and degree of certainty of vein locations. Projection of vein images may be a positive or a negative image. Venipuncture needles may be coated to provide visibility in projected images.Type: GrantFiled: August 16, 2017Date of Patent: December 31, 2019Assignee: AccuVein, Inc.Inventors: Fred Wood, Vincent Luciano, Ron Goldman
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Patent number: 10512402Abstract: Materials and methods are disclosed for screening advanced glycation end-products from the mammalian ocular lens proteins to quantify early biomarkers for the diagnosis of diabetes mellitus and related complications.Type: GrantFiled: April 22, 2016Date of Patent: December 24, 2019Assignee: Board of Trustees of Northern Illinois UniversityInventors: Elizabeth R. Gaillard, Devi Kalyan Karumanchi
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Patent number: 10506925Abstract: A reflectometry instrument includes a light source for emitting an illumination beam that illuminates the macula. A portion of the illumination beam is reflected from the macula and forms a detection beam. The detection beam is indicative of macular pigment in the macula. The instrument also includes a first mirror for reflecting the illumination beam toward the macula and for reflecting the detection beam from the macula. The instrument is configured so that the illumination beam and the detection beam remain separated between the macula and the first mirror.Type: GrantFiled: February 2, 2018Date of Patent: December 17, 2019Assignee: ZeaVision, LLCInventors: Scott J. Huter, Kevin Martin Magrini, Edward Allen DeHoog, Jeff Alan Burke, Nathan Franklin Engel
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Patent number: 10499821Abstract: Techniques, systems and apparatus are described for implementing a heart rate sensor based on optical measurements of color response of human blood. An optical heart rate sensor can include light source circuitry including a first light emitting diode (LED) to output a first source light signal to a target measurement site, a second LED to output a second source light signal to the target measurement site, a first current pulse driver communicatively coupled to the first LED to modulate the first source light signal output from the first LED at a first predetermined frequency and a second current pulse driver communicatively coupled to the second LED to modulate the second source light signal output from the second LED at a second predetermined frequency different from the first predetermined frequency. The optical heart rate sensor can include detector circuitry including a light detecting photodiode connected to a bias voltage.Type: GrantFiled: July 23, 2015Date of Patent: December 10, 2019Assignee: SHENZHEN GOODIX TECHNOLOGY CO., LTD.Inventors: Bo Pi, Yi He
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Patent number: 10492689Abstract: An optical measurement system includes a portable type optical measurement apparatus and a non-portable type optical measurement apparatus larger than the portable optical measurement apparatus. The non-portable type optical measurement apparatus is configured to be communicable to the portable type optical measurement apparatus and to be operated as a main measurement apparatus which executes measurement condition settings and measurement controls based on an input operation from the operation input section and also executes measurement condition settings and measurement controls of the non-portable type optical measurement apparatus by communication. The portable type measurement apparatus is capable of measuring a subject independently of the non-portable type measurement apparatus, and is operated as a sub-measuring apparatus for executing measurement condition settings and measurement controls in accordance with a control by the non-portable type measurement apparatus.Type: GrantFiled: June 24, 2015Date of Patent: December 3, 2019Assignee: Shimadzu CorporationInventor: Akihiro Ishikawa
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Patent number: 10485518Abstract: An imaging apparatus and method determines distribution and a type of tissue attribute in a vascular cross section based on reflected wave data of ultrasound detected by an imaging core and interference light data including a reflected wave of light detected by the imaging core. A portion of match/mismatch is determined by comparing respectively classified vascular tissue attributes. Then, the distribution of the body tissue attributes is displayed by superimposing the distribution on any one of an ultrasound cross-sectional image, an optical interference cross-sectional image, and a composite image between the ultrasound cross-sectional image and the optical interference cross-sectional image, in a display form in which the match/mismatch can be identified.Type: GrantFiled: March 18, 2016Date of Patent: November 26, 2019Assignee: TERUMO KABUSHIKI KAISHAInventor: Youhei Kobayashi
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Patent number: 10456028Abstract: An apparatus for use in the measurement of the optical density of macular pigment in the human eye, and an apparatus for the use in measuring the lens optical density of a human eye. The apparatus is particularly applicable to flicker photometers, which are used to measure the macular pigment in the human eye.Type: GrantFiled: November 8, 2016Date of Patent: October 29, 2019Assignee: Guardion Health Sciences, LLCInventor: Richard Bone
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Patent number: 10459252Abstract: The present application discloses an apparatus for protecting a user's eye from blue light radiation, the apparatus includes a radiation detector configured to convert blue light from a light source into a photo voltage having a voltage value; a processor coupled to the radiation detector and configured to calculate a cumulative radiation intensity based on the voltage value cumulated over a time interval, and to compare the cumulative radiation intensity with a threshold value; and a controller coupled to the processor, configured to adjustably control blocking of at least a portion of blue light from the user's eye when the cumulative radiation intensity exceeds the threshold value.Type: GrantFiled: October 26, 2016Date of Patent: October 29, 2019Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Lijie Zhang, Zhenglong Li, Xuewen Lv