Abstract: An auto-injector confines all functional components inside an enclosed housing, to keep its needle out-of-sight, at all times. Within the housing, a needle holder positions a needle at a location. A drive mechanism then simultaneously engages the needle with a fluid source and accelerates it with a predetermined momentum for insertion into a patient. After fluid delivery, the withdrawn needle is moved to storage within the housing for subsequent disposal.

Abstract: A lifter assembly for actuating a needle of an automatic medication delivery device, includes a motor, a speed reduction device driven by the motor, an output shaft driven by the speed reduction device via a rigid transmission device, a driving lever configured to move the needle, the driving lever being connected to and driven by the output shaft, and a sensing device configured to sense the rotation position of the output shaft. The speed reduction device comprises a worm in mesh with a worm gear. The output shaft, the worm gear and the rigid transmission device cooperatively constitute a four-bar linkage mechanism.

Abstract: The present invention relates A needle assembly for a drug delivery device comprising: a cup-shaped receptacle of non-circular cross section having a bottom section supporting a needle element being adapted to penetrate a pierceable seal of a cartridge to be disposed in a cartridge holder of the drug delivery device, wherein the receptacle comprises fastening means adapted to engage with fastening means of a support section of the cartridge holder for releasably fastening the needle assembly, wherein the fastening means are convertible into a release configuration by changing the radial distance of mutually corresponding fastening means through twisting the receptacle with respect to the support section.

Abstract: The present invention relates to a cartridge holder assembly for a drug delivery device comprising of a cartridge holder adapted to receive a cartridge filled with a medicament to be dispensed by the drug delivery device, wherein the cartridge holder comprises a first through opening at a distal end section to receive a piercing element adapted to penetrate a sealing member of the cartridge, a support structure adjacently arranged to the first through opening; and a constriction member arranged between the support structure and a distal end face of the cartridge and having a second through opening smaller than the first through opening.

Abstract: The present invention relates to a cartridge for a drug delivery device comprising of a container at least partially filled with an injectable medicament, at least one sealing member disposed at a distal end of the container, the sealing member being pierceable by a piercing element for expelling a dose of the medicament, and at least one fixing cap of circular or cylindrical geometry comprising a centric through opening at a distal end face giving access to the sealing member disposed underneath, and comprising at least in sections a structurally strengthened surface structure to keep the sealing member in position and/or to counteract a pressure-induced mechanical deformation of the sealing member, and wherein the distal end face of the fixing cap comprises at least one radially extending corrugation or bead.

Abstract: An infusion set component of a fluid infusion device and/or a fluid infusion port component for delivery of fluid to a patient is compatible with a cooperating fluid channel module. The fluid channel module includes a body section having coupling features to mate with a base of the component. The fluid channel module also includes an interior fluid flow channel formed within the body section to receive fluid from the fluid infusion device and/or from a syringe or pen delivery device. The fluid channel module also includes a conduit having a first end in fluid communication with the interior fluid flow channel, and having a second end to deliver the fluid to the patient.

Abstract: The present disclosure provides a cannula useful for introducing a thermally responsive polymer in situ. In embodiments, the cannula possesses more than one cannula, with the thermally responsive polymer introduced in one cannula, and a material such as a coolant in a second cannula which prevents premature gelling of the thermally responsive polymer.

Abstract: A drug injection apparatus includes a drug container, a needle tube having a first needle tip and a second needle tip, a needle-holding portion which holds the central portion of the needle tube, and a drug container mount from which the second needle tip projects. The drug container has a container body, having a contact portion to be penetrated by the second needle tip and a pressing portion that faces the contact portion, wherein the pressing portion is to be pressed toward the contact portion side so as to deform; a seal member attached to a portion of the contact portion to be penetrated by the second needle tip, and adapted to be brought into close contact with the circumferential surface of the needle tube in liquid-tight manner; and a protective plate adapted to avoid the pressing portion from being penetrated by second needle tip inserted into the container body.

Abstract: The bioinjection device has a housing including a pistol grip and an elongated barrel. A trigger is pivotally mounted to the housing. A plunger and needle are slidable between a first position in which the plunger and needle are slidably disposed in the barrel and a second position in which the plunger and needle extend from an opening in the end of the barrel. A retaining member is disposed about the opening at the end of the barrel. A spring-biased actuation mechanism connects the trigger with the plunger and needle. A membranous cartridge containing bone morphogenic protein, antibiotics, and/or other medication is loaded into the retaining member. A surgeon can inject the cartridge into a bone fracture or degenerative bone tissue during surgery to deliver the medicament directly to the affected site.

Abstract: An actuating mechanism for a hypodermic syringe comprises a flexible tongue (48) allowing the actuating mechanism to be bent to receive a cartridge (10) of injectant closed at its forward end with a septum (14) and at its rearward end with a slidable bung (18). The forward end of the cartridge (10) is fitted into a socket (36) wherein the tail (34a) of a hypodermic needle (34) pierces the septum (14) to access the injectant. With the cartridge (10) fitted, the tongue (48) is straightened, and a spring clip (50) holds the cartridge (10) in position. A plunger (38) can then be depressed, though a guide (42), to drive the bung (18) forward and make the injection. The cartridge (10), which may be a conventional cartridge of any kind, keeps the assembly rigid in use, and the whole assembly is disposed of after a single use, without dismantling.

Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.

Abstract: Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.

Abstract: Various embodiments of the present invention are directed to equalizing pressure in a reservoir containing fluidic media, possibly due to imperfect installation of the reservoir or an external influence such as an altitude or a temperature change. In various embodiments, fluidic media may be expelled from the reservoir through a needle and contained in an interior volume of a pierceable member before the needle pierces the pierceable member to establish a flow path to a user. In other embodiments, fluidic media may be expelled through a port of the reservoir into a chamber. In further embodiments, fluidic media may be expelled through a channel in a plunger head and out a passage in the reservoir when the channel and passage are aligned. In other embodiments, fluidic media may be expelled through a valve, and the valve may be pierceable by a needle to establish a flow path to the user.

Abstract: The present invention relates to a cartridge holder assembly for a drug delivery device as well as to such drug delivery device and to a corresponding method of assembly, wherein the cartridge holder assembly comprises: a cartridge holder (14; 40) adapted to receive a cartridge (12) to be filled with a medicinal product to be dispensed by the drug delivery device, wherein the cartridge holder (14; 40) comprises at least one through opening at a distal end section to receive a piercing element (20) being adapted to penetrate a sealing septum (22) of the cartridge (12), a constriction member (26; 42) being adapted to axially abut against the septum (22) and comprising a through opening (34; 52) to receive the piercing element (20), wherein said through opening (34; 52) is adjustable in diameter.

Abstract: The present invention relates to an arrangement for use in a drug delivery device comprising a cartridge holder, the cartridge holder comprising an opening at its distal end, a needle holder and one or more intermediate elements, wherein when the needle holder is mounted to the cartridge holder and the one or more intermediate elements are arranged in the opening of the cartridge holder whereby the size of the free space within the opening is reduced. Furthermore, it relates to a drug delivery device which is comprising such an arrangement and to a method for stabilizing a septum located at the distal end of a medicament cartridge.

Abstract: The present invention relates to a drug delivery device for dispensing of a dose of a medicinal product, comprising, a housing, a drive mechanism comprising an axially displaceable piston rod to act on a piston of a cartridge containing the medicinal product to be dispensed, wherein the housing is adapted to support a piercing element which is adapted to penetrate a distal end face of the cartridge exclusively on demand. Furthermore, the drug delivery device comprises means for displacing the cartridge from a proximal stop position to a distal stop position in an axial direction and with respect to the housing, wherein in the distal stop position, the cartridge is connected to the piercing element and wherein in the proximal stop position, the cartridge is disconnected from the piercing element such that a fluid transfer between inside volume of the cartridge and the piercing element is interrupted.

Abstract: Various embodiments of the present invention are directed to equalizing pressure in a reservoir containing fluidic media, possibly due to imperfect installation of the reservoir or an external influence such as an altitude or a temperature change. In various embodiments, fluidic media may be expelled from the reservoir through a needle and contained in an interior volume of a pierceable member before the needle pierces the pierceable member to establish a flow path to a user. In other embodiments, fluidic media may be expelled through a port of the reservoir into a chamber. In further embodiments, fluidic media may be expelled through a channel in a plunger head and out a passage in the reservoir when the channel and passage are aligned. In other embodiments, fluidic media may be expelled through a valve, and the valve may be pierceable by a needle to establish a flow path to the user.

Abstract: The application relates to a device for an intermittent or continuous administration of a therapeutical substance, such as insulin, including a base part to which an injection part and a delivery part are fastened. The delivery part includes a reservoir and a pump, and the injection part includes base plate, a cannula part with a body with a through-going opening, and at least one cannula having a proximal end protruding from the lower side of the body and an adhesive portion for fastening the base plate to the skin of the user. The delivery part and the injection part are assembled through a connector having a fluid path leading fluid from the reservoir to the through-going opening in the cannula part.

Abstract: A needle and receiver assembly for use with a syringe cartridge filled with medicine. The assembly includes a cartridge receiver having a hollow interior, an open end sized for receiving at least part of the syringe cartridge, and a closed end opposite the open end. The assembly includes a needle mounted on the receiver having a fluid passage extending between a sharp delivery tip at a distal end of the needle and a sharp access tip at a proximal end of the needle opposite the delivery tip, the needle extending through the closed end of the receiver so the access tip is positioned inside the hollow interior of the receiver and the delivery tip is positioned outside the receiver. The assembly includes a cutter movably mounted in the hollow interior of the receiver for cutting the diaphragm of the cartridge when received in the hollow interior of the receiver.

Abstract: A syringe assembly includes a tubular barrel having an open proximal end, a distal end, and an internal a fluid retaining chamber. A plunger is slidingly received in the chamber and is configured to draw fluid into and expel fluid from the chamber. A hollow projection extends from the distal end of the barrel and a cannula extends from the hollow projection. The cannula may have a spiked tip, a transverse orifice, and longitudinally disposed bi-lateral fluid flow channels. The cannula is adapted to penetrate the seal of a medical access point, such as a medicine vial, IV port, or catheter port. A receiving collar including one or more male threads surrounds the hollow projection and the cannula and is adapted to releasably engage a needle hub. The needle hub has an internal cavity configured to matingly receive and cover the cannula.

Abstract: A pen needle assembly is provided herein for use with a medical injector containing an injector body and a reservoir sealed by a septum encased in the injector body. The pen needle assembly includes a hub and a needle fixed to the hub. The hub is formed to be telescopingly mounted onto a distal end of the injector body using a track that accommodates a guide key. When mounting the hub of the pen needle assembly onto the injector body, a first portion of the track is configured to receive the guide key and to guide the guide key in a straight line across sufficient distance to permit a proximal end of the needle to fully pierce through the septum, without rotation of the needle. A second portion of the track is configured to permit the pen needle assembly to be turned with the proximal end of the needle being located proximally of the septum.

Abstract: An administering device, e.g. an injection device, includes a housing, a reservoir for a drug, the reservoir formed or accommodated by the housing, a dosing member which can perform a dosing movement relative to the housing for setting a dosage of the drug to be administered and a conveying member for delivering the dosage set, wherein the dosing member is blocked or locked in the direction of the dosing movement in a releasable dosing blocking engagement in an initial state of the administering device and released from the block at the end of a priming movement of the conveying member.

Abstract: An intradermal injection adapter includes a body having a longitudinal axis and a central portion located distally relative to the body along the longitudinal axis. The central portion has a cannula channel therethrough extending generally parallel to the longitudinal axis. A cannula within the cannula channel has a sharpened tip for injection into a patient and a sharpened opposite proximal end for injection into a pen injector. A distal protrusion has a first skin contacting surface extending generally parallel to the longitudinal axis. The first skin contacting surface is spaced from the cannula such that a distal portion of the cannula extends generally parallel to the first skin contacting surface.

Abstract: A medication and needle module (20) for an injection device. The module (20) includes a housing (22) including a first portion (39) and a second portion (38) detachably connected together, the second housing portion having a periphery complementarily shaped with a cavity (154) in the injection device (150) to be loadable therein, a primary container (120) within the first housing portion and including a medication filled reservoir (124), a secondary container (70) within the second housing portion and including a medication tillable reservoir, a needle cassette (60) rotatably mounted within the second housing portion and including a plurality of delivery needles (64), and a transfer needle assembly (100) within the housing. The detachability of the second housing portion from the first housing portion permits the second housing portion with the secondary container and the needle cassette to be loaded as a unit independently of the first housing portion into the injection device cavity for use.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device.

Abstract: A seal member is configured to seal a chamber of a drug delivery device which is suitable to contain a drug, wherein the seal member comprises a diaphragm.

Abstract: A syringe assembly includes a syringe body including a distal end. The syringe body defines a fluid chamber therein. The fluid chamber includes a lower end. A septum is disposed at the distal end of the syringe body and is configured to sealingly close the lower end of the fluid chamber. The syringe body and the septum are formed as a single, molded piece.

Abstract: A therapeutic fluid delivery system including, in various examples, a first reservoir configured to house a first therapeutic fluid, a second reservoir configured to house a second therapeutic fluid, and an inlet port configured to receive a fluid delivery needle is described. The inlet port is configured for fluid communication between the fluid delivery needle and the first reservoir, and the inlet port is further configured for fluid communication between the fluid delivery needle and the second reservoir.

Abstract: An auto-injection syringe is provided that includes an injection assembly and a retraction assembly operatively securable to the injection assembly. The retraction assembly includes a hypodermic needle having a needle hub, an end cap having a lower seal through which a portion of the hypodermic needle can pass, a retraction spring disposed between the needle hub and the end cap and maintained in a partially compressed condition therebetween, an upper seal urged against a facially sealing surface of the retraction assembly by the force of the retraction spring on the needle hub so that a sealed area is defined between the upper and lower seals, and a vent device in fluid communication with the sealed area for pressure equalization between the sealed area and an exterior of the retraction assembly.

Abstract: A syringe for administering medicament from a cartridge. The syringe includes a sleeve having an interior for receiving the cartridge extending between a distal hub and a proximal opening. The syringe has a cap selectively covering the proximal opening for retaining the cartridge in the interior of the sleeve. The cap includes a finger grip extending outward from the sleeve for engaging fingers of a user. The syringe also has a plunger rod movably connected to the cap. The plunger rod has a distal connector for selectively connecting the rod to the cartridge plunger when the cartridge is received in the interior of the sleeve to push medicament from the cartridge reservoir as the plunger rod moves with respect to the cap.

Abstract: A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

Abstract: A vascular access device within an external environment may include a body and a septum at least partially housed within the body. Septum may at least substantially seal a lumen extending through the body. The septum may further include at least a first and a second material. At least one of the materials of the septum may be selected or adapted to resist tearing of the septum.

Abstract: A vascular access device may include a body, a single-disk septum in communication with the body, and a rigid member supporting the septum. A method of manufacturing a vascular access device may include providing a body, providing a single-disk septum in communication with the body, and supporting the septum with a rigid member.

Abstract: An injection system applicable to off-the-shelf syringes having a microneedle hub may reduce dead space and isolate the drug fluid from the microneedle chip to avoid compatibility issues. An insert may be disposed inside a male luer fitting and extend so that it is also disposed inside the female luer fitting using an insert. A septum may isolate the drug fluid from the microneedle chip in the hub prior to activation and the septum may, after activation, seal the triangular space in the hub to prevent leakage of fluid back to the syringe.

Abstract: A needle assembly has distal and proximal ends. The needle assembly comprises a body element having distal and proximal ends, an attachment means configured to be attached to a medication delivery device, a button element which is movable from a first position to a second position, and a needle configured to move to the distal direction, when the button element is moved from the first position to the second position.

Abstract: A needle mounting assembly for mounting a pen needle in fluid communication with a medication cartridge. A collet defines an opening in which is slidably fittable the outlet end of the cartridge. The collet is shiftable relative to the cartridge outlet end. When the collet is disposed in a first axial position, a plurality of fingers of the collet extend forward of the cartridge outlet end and are disposed in a first radial arrangement in which a needle hub of the pen needle can be freely axially placed onto and freely axially removed from the plurality of fingers. When the collet is moved to a second position, the plurality of fingers are shifted by engagement with the cartridge outlet end to operationally secure the needle hub. When the collet is moved back to the first position, the plurality of fingers shift back for free axial removal of the needle hub from the mounting assembly.

Abstract: The invention includes a device having a chamber within a syringe. A fluid passageway extends through a syringe piston. A valve is associated with the passageway controlling fluid passage through the piston. The invention includes a piercing structure having a head segment and a body portion, with a channel through the body portion and through at least one surface of the head without passing through the tip. In another aspect the invention encompasses a method of preparing an agent for administration to an individual. A first component is provided within a syringe and a second component is provided within a vial. A closed valve is associated with a fluid passageway between the vial and the syringe barrel through a piston. Valve repositioning allows fluid passage and sliding of the piston joins the first and second components. Repeated sliding of the piston mixes the components to produce the medication agent.

Abstract: The invention relates to a device for connecting a syringe to a container or tubing, particularly for connecting a syringe to a container for receiving infusion-, transfusion-, or enteral nutrition solutions and particularly for connecting a syringe to tubing of a blood tube system of an extracorporeal blood treatment device or to tubing for a venous portal. The invention also relates to a container and tubing with such a device. The device according to the invention has a connecting part (2) which connects to the container or the tubing, the connecting part having a recess (3) in which a membrane (12) is arranged, the membrane closing the channel-shaped recess. A hollow body (22) having a syringe (23) is arranged in the recess (3) of the connecting part (2) in such a manner that the membrane (12) is pierced upon connection of the syringe to the connecting part.

Abstract: An automatic needle device including a housing element, at least one resilient element arranged to be located within the housing element, at least one needle bearing element adapted, when actuated, to be displaced by the at least one resilient element with respect to the housing element from a non-penetration position to a penetration position and a needle guard adapted for positioning with respect to the housing element and wherein displacement of the needle guard is operative to actuate displacement of the at least one needle bearing element from the non-penetration position to the penetration position.

Abstract: A device for administering a fluid product including a housing, a conveying device for the product, a coupling element provided for the drive of the conveying device and which can be rotated about a rotational axis, a first blocking element connected in a rotationally secure manner to the coupling element, a second blocking element detachably engageable with the first blocking element thereby preventing a rotational movement thereof in the drive direction and enabling said rotational movement to take place in the counter dosing direction, a torsion spring connected to the coupling element such that it is stressed by the rotational movement when the blocking elements are engaged in a blocked position and drives the coupling element in a rotary manner after the blocking position is released, and a release element coupled to at least one of the blocking elements such that a release movement of the release element displaces at least one of the blocking elements from the blocked position, the release element also

Abstract: A medical device having a vascular access device including a rotationally activated flow control valve having, a body including a distal adapter and a proximal adapter defining a lumen extending therethrough and a septum. A method of use in which the connection of first and second medical devices results in the automatic activation of the rotational flow control valve.

Abstract: A pen needle assembly is provided herein for use with a medical injector containing an injector body and a reservoir sealed by a septum encased in the injector body. The pen needle assembly includes a hub and a needle fixed to the hub. The hub is formed to be telescopingly mounted onto the distal end of the injector body using a track that accommodates a guide key. When mounting the pen needle assembly onto the injector body, a first portion of the track is configured to receive the guide key and to guide the guide key in a straight line across sufficient distance to permit the proximal end of the needle to fully pierce through the septum, without rotation of the needle. A second portion of the track is configured to permit the pen needle assembly to be turned with the proximal end of the needle being located proximally of the septum.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A housing may have a needle, plunger, and bias mechanism supported within the housing by a tab configured to retain the plunger in position and to allow the plunger to move under bias force imparted by the bias mechanism to move the needle to an insert position when the tab is removed. A base and a structure may be configured for relative movement there between and may be adapted to be secured to a user with a cannula extending through a body of the structure into the user during use of a medical device. A housing may be adapted to be secured to a user to support a medical device operable with an insertion needle, the housing having a magnifying material for increasing visibility of an injection site.

Abstract: A drug-injecting device with a traveling hypodermic or intramuscular needle. The drug-injecting device includes a syringe body which has a base and a top opening into a hollow interior. A membrane is attached across the base of the syringe body, hermetically sealing the reservoir of the syringe from the environment. A plunger is situated within the hollow interior of the syringe body, so that one end of the plunger projects outward through the top of the syringe body. A piston is attached to the other end of the plunger. The plunger is configured to travel back and forth within the hollow interior of the syringe body between a first position and a second position. A needle is attached to the piston so that the needle travels with the plunger when the plunger is moved between the first and second positions.

Abstract: A system includes a durable portion with a durable housing and a separable disposable portion with a disposable housing that selectively engage with and disengage from each other. The disposable housing secures to a patient and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient or with an infusion medium may be part of the disposable portion to allow for disposal after a prescribed use. A reservoir for holding the infusion medium may be part of the disposable portion, and may be supported by the disposable housing. The durable portion may include other components such as electronics for controlling delivery of the infusion medium from the reservoir, and a drive device including a motor and drive linkage.

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: A vascular occlusion device deployment system for placing an occlusion device at a preselected site within the vasculature of a patient. The deployment system employing a pusher having a lumen with an opening at the distal end of the pusher. A vascular occlusion device is connected to the distal end of the pusher by a portion that is removeably disposed within the opening. The portion of the occlusion device is forced out of the opening by an expandable reaction chamber, thereby deploying the occlusion device.

Abstract: The present invention relates to medical devices which are adapted for application to a skin surface of a user and comprise a transcutaneous device which is supplied in a sterile condition. Thus, a medical device is provided, comprising a mounting surface adapted for application to the skin of a subject, a first portion having a first end adapted to penetrate the skin of the subject, and a second portion in fluid communication with the first portion and having a second end. The device further comprises enclosure means being transformable from an initial configuration encapsulating the first and second portions in an initial aseptic state, to a second configuration in which the ends of the first and second portions are allowed to communicate with the exterior through the enclosure means, wherein the enclosure means does not enclose the mounting surface.