Having Means For Metering Material Flow To Or From Body Patents (Class 604/207)
  • Patent number: 11103646
    Abstract: Dosing device for an administration device with a limiting mechanism, comprising a first limiting means with a first stop means, a second limiting means with a second stop means, wherein the second limiting means follows movements of the first limiting means during dosing movements with a defined transmission ratio, and wherein the first and the second stop means each describe a path curve by their movements in such a manner that the two path curves intersect in at least one point or come so close together that the stop means contact one another in a stop position, whereby a blocking of the movement of the limiting means relative to each other during dosing movements can be effected in that the respective path curves described by the first and second stop means are closed and can be run through preferably multiple times by the first stop means, by the second stop means or by both stop means until the stop means contact one another at the stop position.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: August 31, 2021
    Assignee: Ypsomed AG
    Inventors: Jürg Hirschel, Ulrich Moser
  • Patent number: 11071831
    Abstract: Dose detection systems for medication delivery devices are described. One is a module for removable attachment to a dose button of a medication delivery device. A device with a dose detection system is also disclosed. The module includes a processor and a plurality of magnetic sensors, such as, for example, five or six sensors, operably coupled to the processor and configured to detect the positon of a rotating bipolar magnetic ring within the delivery device. Medication identification system may also be provided.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: July 27, 2021
    Assignee: Eli Lilly and Company
    Inventors: Benjamin David Bauer, Timothy Mark Blum, Roy Howard Byerly, Andrea Concu, Marco Cortinovis, Paolo Degan, Jared Alden Judson, Rossano Claudio Massari, Kimberly Ann Ringenberger, Giorgio Maria Sardo, Amin Sedighiamiri, Marco Vergani
  • Patent number: 11071826
    Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a cassette, a door coupled to the housing, a drive mechanism, and a latching assembly. The cassette is removably disposed within the inner volume and is adapted to contain a drug to be administered to a user. The door at least partially encloses the inner volume of the housing and includes a first end defining a latching portion. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the drug out the cassette. The latching assembly is coupled to the drive mechanism and includes a first end and a second end. Upon actuating the drive mechanism, the drive mechanism causes the latching assembly to engage the latching portion of the door to secure the door to the housing.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 27, 2021
    Assignee: AMGEN INC.
    Inventors: Andrew Coles, Chad Quistad, Emanuele Strada, Francesco Lauritano, Alessia Mazzicone, Antonio Antonini
  • Patent number: 11058822
    Abstract: Dosing device for an administration device with a limiting mechanism, comprising a first limiting means with a first stop means, a second limiting means with a second stop means, wherein the second limiting means follows movements of the first limiting means during dosing movements with a defined transmission ratio, and wherein the first and the second stop means each describe a path curve by their movements in such a manner that the two path curves intersect in at least one point or come so close together that the stop means contact one another in a stop position, whereby a blocking of the movement of the limiting means relative to each other during dosing movements can be effected in that the respective path curves described by the first and second stop means are closed and can be run through preferably multiple times by the first stop means, by the second stop means or by both stop means until the stop means contact one another at the stop position.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: July 13, 2021
    Assignee: Ypsomed AG
    Inventors: Jürg Hirschel, Ulrich Moser
  • Patent number: 11062799
    Abstract: The invention relates to an apparatus (2, 3), comprising a mating unit (20-1, 20-2) for releasably attaching the apparatus (2) to a medical device (1) or for releasably receiving at least a part of the medical device (1). The apparatus (2, 3) further comprises one or more optical sensors (25, 26) and/or one or more acoustical sensors (27) for determining information related to a condition and/or use of the medical device (1). The invention further relates to a system comprising such an apparatus (2, 3) and such a medical device (1), to a method (500, 600, 700) and a computer program (61) for determining information related to a condition and/or use of such a medical device (1), and to a computer-readable medium (60) storing such a computer program (61).
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: July 13, 2021
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Schabbach, Amit Kohli
  • Patent number: 11007517
    Abstract: A sub-1 ?L pipette having a small diameter metal tube that is concentrically located within the tip mounting shaft/portion of the pipette and extends from the distal end thereof by some predetermined distance so as to seal against the interior of a pipette tip that is installed to the tip mounting portion. The use of a small diameter metal tube and sealing of the metal tube against the inner surface of the pipette tip near a distal opening of the pipette tip allows for a minimal ullage volume.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 18, 2021
    Assignee: Mettler-Toledo Rainin, LLC
    Inventor: James S. Petrek
  • Patent number: 10971260
    Abstract: A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to be attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 6, 2021
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Gary Searle, Francis L Ross, III
  • Patent number: 10905825
    Abstract: An optical sensor for a delivery device having a piston that displaces a substance, such as a fluid, from a reservoir. The optical sensor has a light source and a detector array for imaging encoding features disposed along a plunger rod coupled to the piston. By virtue of the pattern of encoding features, an absolute position of the plunger rod relative to a fiducial position may be determined uniquely. Thus, the volume of fluid remaining in the reservoir, the rate of fluid delivery, and proper loading of the reservoir may be accurately ascertained. Additionally, the encoding may serve to uniquely identify a version of the reservoir which may be supplied in various versions corresponding, for example, to differing concentrations of a therapeutic agent to be dispensed.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: February 2, 2021
    Assignee: DEKA PRODUCTS LIMITED PARTNERSHIP
    Inventors: Marc A. Mandro, Larry B. Gray
  • Patent number: 10857304
    Abstract: Sensing systems are disclosed for determining the relative rotational movements of members of a medication delivery device which are proportional to the amount of a dose set and delivered by the medication delivery device. The sensing system comprises a first sensor component secured to a first member and a second sensor component secured to a second member. During dose setting, the second member is coupled to a third member which rotates relative to the first member in proportion to the dose set. During dose delivery, the second member is coupled to a fourth member which rotates relative to the first member in proportion to the dose delivered. The sensing system separately detects the relative rotational positions of the first and second sensor components during dose setting and dose delivery, and provides outputs used to determine the amounts of the set and delivered doses. The sensing system outputs this information to a controller which determines the amount of the dose set and delivered.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 8, 2020
    Assignee: Eli Lilly and Company
    Inventor: Roy H. Byerly
  • Patent number: 10850039
    Abstract: A drive assembly for a drug delivery device includes a spring member, a piston rod and a piston rod nut being engaged with the piston rod. The piston rod nut is configured to rotate and axially move during dose setting. The spring member is compressed when the piston rod nut is moved during the dose setting. The piston rod nut is rotationally fixed during dose dispensing.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: December 1, 2020
    Assignee: Sanofi
    Inventor: Simon Lewis Bilton
  • Patent number: 10799646
    Abstract: An injection device for delivering an injection comprises a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end; and a release mechanism comprising an impediment, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede the delivery of the injection, and a second position, in which the impediment is in a non-impeding position so as to not impede the delivery of the injection, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: October 13, 2020
    Assignee: Cilag GmbH International
    Inventors: Ahmad Bitar, Douglas Ivan Jennings
  • Patent number: 10799641
    Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having an opening, a dose selector operable to set a dose by rotation relative to the housing, a release member controlling movement of a piston in a dispensing direction, and a display comprising a units number wheel and a tens number wheel which are coupled to each other such that a continuous rotation of the units number wheel is translated into an intermittent rotary motion of the tens number wheel. The release member rotates, during dose dispensing, an angle corresponding to the dose set by the dose selector, thereby allowing a piston to move in a dispensing direction.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 13, 2020
    Assignee: Sanofi
    Inventors: Joseph Butler, Anthony Paul Morris, William Geoffrey Arthur Marsh, Matthew Meredith Jones
  • Patent number: 10792435
    Abstract: An injection system, including an injector having a dispensing mechanism configured to dispense a medicament, and a ready-to-use indicator. The ready-to-use indicator includes a controller configured to interact with the ready-to-use indicator and an audio and/or visual indicator, a temperature sensor, and a temperature analog having similar thermodynamic properties of the medicament. The temperature sensor is configured to detect a temperature of the temperature analog which represents the dynamic temperature of medicament as the medicament is heated or cooled. The temperature sensor is configured to communicate the detected temperature to the controller and to alert the controller when a preset temperature is reached. The ready-to-use indicator is configured to alert a user when the preset temperature is reached, signifying the medicament is thermally ready to be delivered by the dispensing mechanism. The audio and/or visual indicator is configured to display indicate one or more notifications to the user.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: October 6, 2020
    Assignee: West Pharmaceutical Services, Inc.
    Inventors: Tommy Gene Davis, Brian Klueppel, Paul Benson, Anthony G. Esposito, Jason Choi
  • Patent number: 10792434
    Abstract: A medicament delivery device includes a body having a proximal end and a distal end, in turn comprising a distal housing part, and a medicament container holder, adapted to receive a medicament container; a dose setting drum for setting a dose when rotated in a first direction and for delivering a dose when rotated in a second direction, and a drive drum sleeve selectively operably connectable to a piston plunger for delivering a dose.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: October 6, 2020
    Assignee: SHL MEDICAL AG
    Inventor: Anders Wieselblad
  • Patent number: 10773025
    Abstract: An optical decoding system including an optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device and a processor configured to: (i) cause the optical sensor to capture images of the first and second rotatable components at least at the beginning and end of a medicament dose dispensing process; (ii) determine a rotational position of both the first and second rotatable components in each of the captured images; and (iii) determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by the dose setting and dispensing mechanism of the drug delivery device.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: September 15, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Markus Ploch
  • Patent number: 10773032
    Abstract: A smart monitoring device for automatically monitoring the injection of medicines such as insulin which can be retrofitted to a conventional insulin pen in which the device has an optical motion sensor for detecting actuation of the injection pen together with an optional accelerometer sensor, medicament temperature and mounting sensors, the monitoring device being communicable with external smart devices such as smartphones.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: September 15, 2020
    Assignee: SHL MEDICAL AG
    Inventors: William Robert Cirillo, John Pascal Hughes
  • Patent number: 10758676
    Abstract: The present invention relates to a drug delivery device for setting and dispensing of a dose of a medicament is presented comprising a housing to accommodate a cartridge filled with the medicament, an electrically operated drive mechanism to be operably engaged with the cartridge to expel a predefined dose of the medicament from the cartridge, and at least one dose element displaceably arranged relative to the housing to set and/or to dispense the dose of the medicament, wherein the dose element and the drive mechanism are mechanically decoupled from each other.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: September 1, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Alex John Baker, James Andrew Holt, Timothy Lewis Sharpe
  • Patent number: 10751477
    Abstract: A determination device for determining a value representing a dose of a dose metering device includes an eddy-current-based rotational angle sensor. The rotational angle sensor can be coupled to a rotatable dosing knob of the dose metering device and can image a rotational angle of the dosing knob representing the dose in a rotational angle signal. The determination device further includes an analysis device that can establish the value of the dose using the rotational angle signal.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: August 25, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Fabian Utermoehlen, Andreas Merz, Stefan Leidich
  • Patent number: 10702657
    Abstract: The present invention relates to an information provider assembly to be used with a medicament delivery device for providing status information of the medicament delivery device, which medicament delivery device is provided with a medicament dose setting mechanism, the information provider assembly comprising a housing designed to be releasibly connectable to said medicament delivery device, the information provider assembly further comprising a measuring unit capable of measuring the position of a measuring surface on said medicament delivery device, which measuring surface is moved as the medicament dose setting mechanism is operated.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: July 7, 2020
    Assignee: SHL MEDICAL AG
    Inventors: Daniel Säll, Rasmus Renstad, Nikolaj Hautaviita
  • Patent number: 10702658
    Abstract: A sliding cover for a liquid delivery device, such as a cap (100) for a pen injector (200), incorporates a set of sensors including a first optical sensor (110) with an output which changes during uncapping or capping motions on passing of a plunger (220) of the pen injector. This output is used together with at least one additional sensor output to determine the position of the plunger along a cylinder (210) of the liquid delivery device. By monitoring changes in the plunger position, the quantity of dosages delivered by the liquid delivery device can be determined, displayed, stored and/or transmitted to an external device for further data processing or storage.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: July 7, 2020
    Assignee: PATIENTS PENDING LTD.
    Inventor: Avraham Shekalim
  • Patent number: 10695499
    Abstract: The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rotation with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, movin
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 30, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Carsten Schau Andersen, Simon Roervig, Steffen Hansen
  • Patent number: 10695504
    Abstract: A drug delivery system comprises means to create a log of expelled dose amounts of drug. Stored dose amounts determined within a given time period are combined to a single combined dose amount. The given time period is initiated by a detected expelling event taking place (i) a given amount of time after a previous detected expelling event, or (ii) after a given detected action. By this arrangement it is possible to create a log corresponding to what a user considers to be a single dose, i.e. combining “split doses” to create a single log entry for a per se split dose.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: June 30, 2020
    Assignee: Novo Nordisk A/S
    Inventors: Preben Mikael Nielsen, Nikolaj Frogner Krusell, Jens Christian Andersen, Nikolaj Eusebius Jakobsen
  • Patent number: 10688246
    Abstract: The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 23, 2020
    Assignee: Sanofi
    Inventors: Anthony Paul Morris, Matthew Meredith Jones, Oliver Benjamin Brown
  • Patent number: 10684156
    Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: June 16, 2020
    Assignee: Common Sensing Inc.
    Inventors: Richard Whalley, James White
  • Patent number: 10668219
    Abstract: A finger grip arranged to be connected to a syringe barrel having a plunger and a plunger rod for driving said plunger. The finger grip includes a body having a lower side with finger supporting surfaces for supporting fingers of a user during handling and an engagement member being moveable between an inactive position where the engagement member is arranged not to engage with the plunger rod of the syringe barrel and an active position where the engagement member is arranged to engage with a grooved surface on the plunger rod of the syringe such that feedback is given to a user as the plunger is moved relative to the finger grip. An activation member for moving the engagement member from said inactive position to said active position is built-in into the finger grip.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: June 2, 2020
    Assignee: NESTLÉ SKIN HEALTH S.A.
    Inventors: Jonas Tornsten, Max Blomqvist, Pekka Niskala
  • Patent number: 10668222
    Abstract: An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 2, 2020
    Assignee: Sanofi
    Inventor: Paul Roger Griffin
  • Patent number: 10661020
    Abstract: A mechanical device for assisting medication injection is provided herein comprising a connector having a distal end and a proximal end; a piston rod locked in said connector before medication injection; a spring configured to bias said piston rod distally; a releasable restraining means configured to releasably restrain said piston rod in a locked state against said biasing of said spring, wherein, upon release of said releasable restraining means, said piston rod moves distally under force of said spring; an activation means configured to release said releasable restraining means; and a mounting means for mounting a syringe at said distal end of said connector.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: May 26, 2020
    Inventor: Min Wei
  • Patent number: 10603435
    Abstract: The disclosure is directed to a drive mechanism for use in a drug delivery device having a cartridge, the mechanism comprising a base element, a toothed piston rod movable from a first retracted position corresponding to a full cartridge to a second extended position corresponding to an empty cartridge, wherein the piston rod is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod, wherein the toothed piston rod comprises multiple rigid rod pieces which are connected by hinges, and a drive spring, which is fixed to the base element with one end and fixed to the drive gear with another end and which exerts a force or torque to the drive gear for rotating the drive gear relative to the base element, which rotation results in a movement of the toothed piston rod.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: March 31, 2020
    Assignee: Sanofi
    Inventors: William Geoffrey Arthur Marsh, Matthew Meredith Jones, Joseph Butler, Anthony Paul Morris
  • Patent number: 10576210
    Abstract: The present disclosure relates to a drive mechanism for an injection device for setting and dispensing of a dose of a medicament, the drive mechanism including a tubular shaped housing component extending in an axial direction (z) and comprising an inner thread, a tubular shaped display member having an outer thread engaged with the inner thread, and a dose member axially displaceable between a dose setting position (S) and a dose dispensing position relative to the display member, wherein the display member includes at least one blocking member on its outer circumference to axially engage with a blocking structure on an inside facing sidewall portion of the housing component to block an axial displacement of the dose member from the dose setting position (S) towards the dose dispensing position.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: March 3, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Robert Veasey, John David Cross
  • Patent number: 10569025
    Abstract: An injection device for dosing and for releasing a defined dose of a liquid product includes: a threaded rod with a thread that includes teeth; a rotating sleeve with an engaging element that can engage with the teeth of the threaded rod; a guide sleeve having an engaging element that can engage with the teeth of the threaded rod; and a dosing sleeve arranged in an axially moveable manner in relation to the rotating sleeve and the guide sleeve, the dosing sleeve in a threaded engagement with the rotating sleeve.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: February 25, 2020
    Assignee: TecPharma Licensing AG
    Inventors: Markus Tschirren, Juerg Hirschel
  • Patent number: 10543316
    Abstract: An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, and a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 28, 2020
    Assignee: Antares Pharma, Inc.
    Inventors: Paul R. Lesch, Matthew H. Rust, Thomas E. Kramer
  • Patent number: 10532160
    Abstract: An optical decoding system comprising: a first optical sensor configured to be directed at a first rotatable component of a drug delivery device; a second optical sensor configured to be directed at a second rotatable component of a drug delivery device; and a processor configured to: receive signals from the first optical sensor, wherein the signals from the first optical sensor represent encoded dosage values present on the first rotatable component; receive signals from the second optical sensor, wherein the signals from the second optical sensor represent whether the second rotatable component is rotating or not; and to determine from the received signals whether the drug delivery device is in a drug dose dialling mode or a drug dose delivery mode.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: January 14, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Paul Richard Draper
  • Patent number: 10493211
    Abstract: An injection device includes a housing; a receptacle for injection fluid; a dosing piston to press out the injection fluid; a feed part connected to the dosing piston via a first threaded connection; a slide having a thread of a second threaded connection; and, a setting part having a thread of a third threaded connection and configured to set an amount of injection fluid to be dispensed. The setting part moves in the distal direction by virtue of the third threaded connection when the amount of injection fluid to be dispensed is being set. The setting part can move in the proximal direction when the injection fluid is pressed out. A latching unit defines a latching position of the setting part and acts between the setting part and housing. Each latching position has an unequivocal rotational position of the setting part in relation to the housing assigned thereto.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: December 3, 2019
    Assignee: Haselmeier AG
    Inventor: Joachim Keitel
  • Patent number: 10478565
    Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprising a housing, a clicker member (2) and a clutch member (1) comprising a rotatable clutch feature (20). The assembly further comprises a counter clicker (8) which is configured to interact with the clicker member (2) to form a clicker mechanism, and a spring element (3) arranged between the clicker member (2) and the clutch member (1), the spring element (3) being arranged to move the clutch member (1) towards the first position and away from the clicker member (2) away from each other.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: November 19, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Torsten Kraft
  • Patent number: 10463802
    Abstract: Drug delivery device comprising a housing retaining a primary drug delivery assembly for the delivery of a primary medicament with a primary dose setting member configured to rotate in a helical movement to set a dose of the primary medicament and a secondary drug delivery assembly for the delivery of a secondary medicament. A dose dial is movable between a first position and a second position in axial direction and is rotationally constrained with respect to the housing when moved from the first position into the second position and is rotationally constrained to the primary dose setting member in the second position for setting a dose of the primary medicament. A secondary drive sleeve of the secondary drug delivery assembly serves for dispense of the secondary medicament. The dose dial and the secondary drive sleeve can be coupled for dose setting.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: November 5, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Paul Hayton, James West, James Coop, Stephen Francis Gilmore
  • Patent number: 10446269
    Abstract: An apparatus is disclosed, comprising a detector unit comprising a detector configured to detect an actuation action performable via the detector unit to an actuation button of a medical device to cause the medical device to eject at least a portion of a medicament comprised in the medical device. The detector is configured to detect the actuation action based on a detection of a force and/or a touch applied to the detector unit as part of the actuation action. The apparatus further comprises an electric unit connected to the detector and configured to store and/or provide information related to the detected actuation action. Furthermore, an according method and a computer program for controlling this method are disclosed.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 15, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Matthias Scharf, Christoph Dette, Michael Schrack, Olaf Zeckai
  • Patent number: 10413676
    Abstract: A medication injection device includes a plunger head having an elastomer housing that fits within a barrel. The plunger head includes an ultrasonic transducer that sends and receives ultrasonic signals in the form of ultrasonic waves, an antenna, a microcontroller that interfaces with the ultrasonic transducer and the antenna, and a power source that powers the microcontroller and the ultrasonic transducer. The ultrasonic transducer, the antenna, the microcontroller, and the power source may be at least partially encapsulated in the elastomer housing. The microcontroller may be programmed to measure echo times of the ultrasonic waves, compare consecutive echo times, and apply a compensation factor. The microcontroller may also be programmed to calculate a volume of medication dispensed from the barrel.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 17, 2019
    Assignee: Verily Life Sciences LLC
    Inventor: Benjamin David Krasnow
  • Patent number: 10383998
    Abstract: The present invention relates to a method and to a monitoring device for monitoring operation of a drug delivery device, the monitoring device comprising of at least a first and a second sensor arranged at a distance from each other with regard to a first direction and being adapted to generate a first and a second electrical signal in response to an operation of the device, a processing unit configured to determine a time delay between the first and the second electrical signals and being adapted to determine at least one state parameter of the drug delivery device on the basis of said time delay.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 20, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Alexander Allerdings
  • Patent number: 10376653
    Abstract: The present invention relates to a medicament delivery device comprising a generally tubular distal housing part (10; 110) having opposite proximal and distal ends, wherein third mechanically coded interface means (11; 111) are arranged on its proximal end; a generally tubular proximal housing (20; 120) part having opposite proximal and distal ends and being releasibly connected to said distal housing part, wherein with fourth mechanically coded interface means (22; 122) are arranged on its distal end; a medicament container having a slidable stopper, wherein said container is arranged to be positioned within said proximal housing part; a plunger rod (60; 160) arranged within said distal housing; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device; wherein said device further comprises an interface member (50; 150) comprising first (51; 151) and second (52; 152) mechanicall
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 13, 2019
    Assignee: SHL MEDICAL AG
    Inventors: Lennart Brunnberg, Anders Wieselblad, Jonas Norebring
  • Patent number: 10342927
    Abstract: The operation member (11) has a central opening (17) with a periphery (18) and at least one protruding element (20) arranged on the periphery and extending into the opening, which is surrounded by a protruding rim (21). The protruding rim is interrupted along the periphery by at least one gap (22). If more than one gap is provided, the gaps are arranged such that the pattern of the gaps does not comprise a symmetry that would allow a rotation different from an integer multiple of 360° around a central axis of the opening to map the complete pattern of gaps onto itself. The operation member may be combined with a drive member comprising abutments in positions corresponding to the positions of the gaps.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: July 9, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Patrick Steiner
  • Patent number: 10314980
    Abstract: A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 11, 2019
    Assignee: NORTON HEALTHCARE LIMITED
    Inventors: Neil Cammish, Mark Horlock
  • Patent number: 10300209
    Abstract: A feedback element for a medicament delivery device, wherein the feedback element comprises two outer longitudinally extending flexible legs (21b) having a proximal and a distal end, and two inner longitudinally extending legs (19) having a proximal and a distal end; wherein the two inner longitudinally extending legs (19) are connected at their proximal ends by a proximal transversal end portion (21d) defining a guide extension and wherein each outer longitudinally extending flexible leg (21b) is connected to one inner longitudinally extending leg (19) by a distal transversal end portion (21a) and wherein each outer longitudinally extending flexible leg (21b) extends at its proximal end radially outwards defining a radial foot 21c.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 28, 2019
    Assignee: SHL Medical AG
    Inventor: Justin Stewart
  • Patent number: 10286155
    Abstract: A pen type drug injection device includes a housing, a dose dial member, a torsion spring fixed between the housing and the dial member such that energy is accumulated in the torsion spring upon rotation of the dial member relative to the housing, a drive member engaging a lead screw, a first clutch, and a second clutch. The first clutch couples the drive member and the housing, in a coupled state and allows relative rotation between them in a de-coupled state. The second clutch rotationally couples the drive member and the dial member in a coupled state and allows clockwise and anti-clockwise rotation between them in a de-coupled state. The second clutch includes a ratchet clicker with teeth having different tooth angles in the clockwise and the anti-clockwise direction, such that, in the de-coupled state, the teeth override each other with different resistance in opposite directions.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: May 14, 2019
    Assignee: Sanofi
    Inventors: Simon Lewis Bilton, David Aubrey Plumptre, Matthew Jones, Joseph Butler
  • Patent number: 10286156
    Abstract: The present invention relates to a monitoring device for monitoring operation of a drug delivery device and to a respective drug delivery device, wherein the monitoring device comprises: a fastening member (32) to releasably attach the monitoring device to an axially elongated housing (14) of the drug delivery device (10), a sliding member (40) shiftable relative to the fastening member (32) in an axial direction (1, 2) and being adapted to operably engage with at least one dose setting component (17, 18, 26) of the drug delivery device (10) to follow an axial displacement of the dose setting component (17, 18, 26) relative to the housing component (14), a first sensor arrangement (36, 46) for detecting a rotation of the dose setting component (17, 18, 26) relative to the fastening member (32), a second sensor arrangement (38, 48) for detecting an axial displacement of the sliding member (40) relative to the fastening member (32), and a processing member (34) coupled to the first and to the second sensor a
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: May 14, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Jasmin Groeschke, Alexander Allerdings, Jan-Peter Spengler, Christoph Dette, Matthias Scharf, Andreas Bode, Michael Schrack
  • Patent number: 10281804
    Abstract: An image processing apparatus includes a three-dimensional space information storage unit, a projection unit, an operation acquisition unit, a reference guide rail decision unit, and a motion vector calculation unit. The projection unit projects and draws a cross-sectional plane onto a projection plane on the basis of information on a position of the cross-sectional plane stored by the three-dimensional space information storage unit. The reference guide rail decision unit decides a reference guide rail on the basis of information on a position of a slide operation acquired by the operation acquisition unit.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 7, 2019
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Hiroyuki Yamahara, Ankit Sharma, Armand Simon Alymamy Girier, Yeonsoo Yang
  • Patent number: 10272204
    Abstract: The present invention is directed to a drug delivery device comprising a cartridge with a movable bung, a drive mechanism including a bearing for driving the bung in a distal direction for delivering a medicament and a piston rod for actuating the bearing. An electric conductor for transmitting an electrical signal is provided, wherein the electric conductor is configured such that a conductive connection is established or interrupted when the piston rod contacts the bearing or when the bearing contacts the bung. The invention is further directed to a method for detecting the contact between the drive mechanism and the movable bung.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 30, 2019
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Jugl, Axel Teucher
  • Patent number: 10265478
    Abstract: An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose set direction (105) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction (106) opposite to the dose set direction (105).
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 23, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Garen Kouyoumjian, Robert Veasey, David Plumptre, Christopher Jones, Catherine Anne MacDonald, James May
  • Patent number: 10245384
    Abstract: An optical decoding system including an optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device and a processor configured to: (i) cause the optical sensor to capture images of the first and second rotatable components at least at the beginning and end of a medicament dose dispensing process; (ii) determine a rotational position of both the first and second rotatable components in each of the captured images; and (iii) determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by the dose setting and dispensing mechanism of the drug delivery device.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: April 2, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Markus Ploch
  • Patent number: 10213554
    Abstract: A medial assembly comprises a logging first unit adapted to be mounted on a drug delivery device second unit from a fully un-mounted to a fully mounted position along a path. The first unit comprises a switch operatable between an off- and an on-state when the first unit is mounted on the second unit, the switch being in the on-state when the first unit is mounted within a first distance from the fully mounted position, and in the off-state when the first unit is mounted outside the first distance from the fully mounted position, and a snap lock operatable from an initial state through an expanded state to a snap-in state when the first unit is mounted on the second unit, the snap lock being in the snap-in state when the first unit is mounted within a second distance from the fully mounted position, the second distance being shorter than the first distance. By this arrangement it is ensured that the switch will be in the on-state before the snap lock is in the snap-in state.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: February 26, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Jens Christian Andersen, Preben Mikael Nielsen, Nikolaj Eusebius Jakobsen, Nikolaj Frogner Krusell
  • Patent number: 10207056
    Abstract: A set of members for a drug delivery device comprises at least two components for the device, wherein both components are provided with a marking, the markings being substantially equivalent or identical. Furthermore, a drug delivery device and a set of drug delivery devices are provided.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: February 19, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Richard James Vincent Avery, Christopher Nigel Langley, James Alexander Senior, James Alexander Davies