Having Means For Metering Material Flow To Or From Body Patents (Class 604/207)
  • Patent number: 10688246
    Abstract: The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 23, 2020
    Assignee: Sanofi
    Inventors: Anthony Paul Morris, Matthew Meredith Jones, Oliver Benjamin Brown
  • Patent number: 10684156
    Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: June 16, 2020
    Assignee: Common Sensing Inc.
    Inventors: Richard Whalley, James White
  • Patent number: 10668222
    Abstract: An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. The assembly is configured such that, in a first portion of the thread, the nut member includes a first position with respect to an axis transversal to the rotational axis and in a second portion of the thread, the nut member includes a second position with respect to the axis transversal to the rotational axis. The nut member is configured to perform a tilting movement from the first position into the second position when the nut member passes from the first portion to the second portion. Furthermore, a drug delivery device comprising the assembly is described.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 2, 2020
    Assignee: Sanofi
    Inventor: Paul Roger Griffin
  • Patent number: 10668219
    Abstract: A finger grip arranged to be connected to a syringe barrel having a plunger and a plunger rod for driving said plunger. The finger grip includes a body having a lower side with finger supporting surfaces for supporting fingers of a user during handling and an engagement member being moveable between an inactive position where the engagement member is arranged not to engage with the plunger rod of the syringe barrel and an active position where the engagement member is arranged to engage with a grooved surface on the plunger rod of the syringe such that feedback is given to a user as the plunger is moved relative to the finger grip. An activation member for moving the engagement member from said inactive position to said active position is built-in into the finger grip.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: June 2, 2020
    Assignee: NESTLÉ SKIN HEALTH S.A.
    Inventors: Jonas Tornsten, Max Blomqvist, Pekka Niskala
  • Patent number: 10661020
    Abstract: A mechanical device for assisting medication injection is provided herein comprising a connector having a distal end and a proximal end; a piston rod locked in said connector before medication injection; a spring configured to bias said piston rod distally; a releasable restraining means configured to releasably restrain said piston rod in a locked state against said biasing of said spring, wherein, upon release of said releasable restraining means, said piston rod moves distally under force of said spring; an activation means configured to release said releasable restraining means; and a mounting means for mounting a syringe at said distal end of said connector.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: May 26, 2020
    Inventor: Min Wei
  • Patent number: 10603435
    Abstract: The disclosure is directed to a drive mechanism for use in a drug delivery device having a cartridge, the mechanism comprising a base element, a toothed piston rod movable from a first retracted position corresponding to a full cartridge to a second extended position corresponding to an empty cartridge, wherein the piston rod is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod, wherein the toothed piston rod comprises multiple rigid rod pieces which are connected by hinges, and a drive spring, which is fixed to the base element with one end and fixed to the drive gear with another end and which exerts a force or torque to the drive gear for rotating the drive gear relative to the base element, which rotation results in a movement of the toothed piston rod.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: March 31, 2020
    Assignee: Sanofi
    Inventors: William Geoffrey Arthur Marsh, Matthew Meredith Jones, Joseph Butler, Anthony Paul Morris
  • Patent number: 10576210
    Abstract: The present disclosure relates to a drive mechanism for an injection device for setting and dispensing of a dose of a medicament, the drive mechanism including a tubular shaped housing component extending in an axial direction (z) and comprising an inner thread, a tubular shaped display member having an outer thread engaged with the inner thread, and a dose member axially displaceable between a dose setting position (S) and a dose dispensing position relative to the display member, wherein the display member includes at least one blocking member on its outer circumference to axially engage with a blocking structure on an inside facing sidewall portion of the housing component to block an axial displacement of the dose member from the dose setting position (S) towards the dose dispensing position.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: March 3, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Robert Veasey, John David Cross
  • Patent number: 10569025
    Abstract: An injection device for dosing and for releasing a defined dose of a liquid product includes: a threaded rod with a thread that includes teeth; a rotating sleeve with an engaging element that can engage with the teeth of the threaded rod; a guide sleeve having an engaging element that can engage with the teeth of the threaded rod; and a dosing sleeve arranged in an axially moveable manner in relation to the rotating sleeve and the guide sleeve, the dosing sleeve in a threaded engagement with the rotating sleeve.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: February 25, 2020
    Assignee: TecPharma Licensing AG
    Inventors: Markus Tschirren, Juerg Hirschel
  • Patent number: 10543316
    Abstract: An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, and a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 28, 2020
    Assignee: Antares Pharma, Inc.
    Inventors: Paul R. Lesch, Matthew H. Rust, Thomas E. Kramer
  • Patent number: 10532160
    Abstract: An optical decoding system comprising: a first optical sensor configured to be directed at a first rotatable component of a drug delivery device; a second optical sensor configured to be directed at a second rotatable component of a drug delivery device; and a processor configured to: receive signals from the first optical sensor, wherein the signals from the first optical sensor represent encoded dosage values present on the first rotatable component; receive signals from the second optical sensor, wherein the signals from the second optical sensor represent whether the second rotatable component is rotating or not; and to determine from the received signals whether the drug delivery device is in a drug dose dialling mode or a drug dose delivery mode.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: January 14, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Paul Richard Draper
  • Patent number: 10493211
    Abstract: An injection device includes a housing; a receptacle for injection fluid; a dosing piston to press out the injection fluid; a feed part connected to the dosing piston via a first threaded connection; a slide having a thread of a second threaded connection; and, a setting part having a thread of a third threaded connection and configured to set an amount of injection fluid to be dispensed. The setting part moves in the distal direction by virtue of the third threaded connection when the amount of injection fluid to be dispensed is being set. The setting part can move in the proximal direction when the injection fluid is pressed out. A latching unit defines a latching position of the setting part and acts between the setting part and housing. Each latching position has an unequivocal rotational position of the setting part in relation to the housing assigned thereto.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: December 3, 2019
    Assignee: Haselmeier AG
    Inventor: Joachim Keitel
  • Patent number: 10478565
    Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprising a housing, a clicker member (2) and a clutch member (1) comprising a rotatable clutch feature (20). The assembly further comprises a counter clicker (8) which is configured to interact with the clicker member (2) to form a clicker mechanism, and a spring element (3) arranged between the clicker member (2) and the clutch member (1), the spring element (3) being arranged to move the clutch member (1) towards the first position and away from the clicker member (2) away from each other.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: November 19, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Torsten Kraft
  • Patent number: 10463802
    Abstract: Drug delivery device comprising a housing retaining a primary drug delivery assembly for the delivery of a primary medicament with a primary dose setting member configured to rotate in a helical movement to set a dose of the primary medicament and a secondary drug delivery assembly for the delivery of a secondary medicament. A dose dial is movable between a first position and a second position in axial direction and is rotationally constrained with respect to the housing when moved from the first position into the second position and is rotationally constrained to the primary dose setting member in the second position for setting a dose of the primary medicament. A secondary drive sleeve of the secondary drug delivery assembly serves for dispense of the secondary medicament. The dose dial and the secondary drive sleeve can be coupled for dose setting.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: November 5, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Paul Hayton, James West, James Coop, Stephen Francis Gilmore
  • Patent number: 10446269
    Abstract: An apparatus is disclosed, comprising a detector unit comprising a detector configured to detect an actuation action performable via the detector unit to an actuation button of a medical device to cause the medical device to eject at least a portion of a medicament comprised in the medical device. The detector is configured to detect the actuation action based on a detection of a force and/or a touch applied to the detector unit as part of the actuation action. The apparatus further comprises an electric unit connected to the detector and configured to store and/or provide information related to the detected actuation action. Furthermore, an according method and a computer program for controlling this method are disclosed.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 15, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Matthias Scharf, Christoph Dette, Michael Schrack, Olaf Zeckai
  • Patent number: 10413676
    Abstract: A medication injection device includes a plunger head having an elastomer housing that fits within a barrel. The plunger head includes an ultrasonic transducer that sends and receives ultrasonic signals in the form of ultrasonic waves, an antenna, a microcontroller that interfaces with the ultrasonic transducer and the antenna, and a power source that powers the microcontroller and the ultrasonic transducer. The ultrasonic transducer, the antenna, the microcontroller, and the power source may be at least partially encapsulated in the elastomer housing. The microcontroller may be programmed to measure echo times of the ultrasonic waves, compare consecutive echo times, and apply a compensation factor. The microcontroller may also be programmed to calculate a volume of medication dispensed from the barrel.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: September 17, 2019
    Assignee: Verily Life Sciences LLC
    Inventor: Benjamin David Krasnow
  • Patent number: 10383998
    Abstract: The present invention relates to a method and to a monitoring device for monitoring operation of a drug delivery device, the monitoring device comprising of at least a first and a second sensor arranged at a distance from each other with regard to a first direction and being adapted to generate a first and a second electrical signal in response to an operation of the device, a processing unit configured to determine a time delay between the first and the second electrical signals and being adapted to determine at least one state parameter of the drug delivery device on the basis of said time delay.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 20, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Alexander Allerdings
  • Patent number: 10376653
    Abstract: The present invention relates to a medicament delivery device comprising a generally tubular distal housing part (10; 110) having opposite proximal and distal ends, wherein third mechanically coded interface means (11; 111) are arranged on its proximal end; a generally tubular proximal housing (20; 120) part having opposite proximal and distal ends and being releasibly connected to said distal housing part, wherein with fourth mechanically coded interface means (22; 122) are arranged on its distal end; a medicament container having a slidable stopper, wherein said container is arranged to be positioned within said proximal housing part; a plunger rod (60; 160) arranged within said distal housing; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device; wherein said device further comprises an interface member (50; 150) comprising first (51; 151) and second (52; 152) mechanicall
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 13, 2019
    Assignee: SHL MEDICAL AG
    Inventors: Lennart Brunnberg, Anders Wieselblad, Jonas Norebring
  • Patent number: 10342927
    Abstract: The operation member (11) has a central opening (17) with a periphery (18) and at least one protruding element (20) arranged on the periphery and extending into the opening, which is surrounded by a protruding rim (21). The protruding rim is interrupted along the periphery by at least one gap (22). If more than one gap is provided, the gaps are arranged such that the pattern of the gaps does not comprise a symmetry that would allow a rotation different from an integer multiple of 360° around a central axis of the opening to map the complete pattern of gaps onto itself. The operation member may be combined with a drive member comprising abutments in positions corresponding to the positions of the gaps.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: July 9, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Patrick Steiner
  • Patent number: 10314980
    Abstract: A dispensing mechanism for administering a dosage of a medicament includes dosage setting means (7) for setting the dosage of a medicament to be administered; expelling means (15) for expelling a medicament from a medicament container; and coupling means (21) operatively coupled with the dosage setting means (7) and the expelling means (15), wherein the coupling means (21) is arranged to convert displacement of the dosage setting means (7) into a displacement of the expelling means (15) in a first direction, wherein the expelling means (15) includes a ratchet means (18a, 18b), and wherein the mechanism includes a first and a second independently moveable resisting pawl (14a, 14b) means facing a common side of the ratchet means (18), the first and the second resisting pawl means (14a, 14b) being configured to engage with the ratchet means (18a, 18b) and resist displacement of the expelling means (15) in a second direction opposite to said first direction.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 11, 2019
    Assignee: NORTON HEALTHCARE LIMITED
    Inventors: Neil Cammish, Mark Horlock
  • Patent number: 10300209
    Abstract: A feedback element for a medicament delivery device, wherein the feedback element comprises two outer longitudinally extending flexible legs (21b) having a proximal and a distal end, and two inner longitudinally extending legs (19) having a proximal and a distal end; wherein the two inner longitudinally extending legs (19) are connected at their proximal ends by a proximal transversal end portion (21d) defining a guide extension and wherein each outer longitudinally extending flexible leg (21b) is connected to one inner longitudinally extending leg (19) by a distal transversal end portion (21a) and wherein each outer longitudinally extending flexible leg (21b) extends at its proximal end radially outwards defining a radial foot 21c.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 28, 2019
    Assignee: SHL Medical AG
    Inventor: Justin Stewart
  • Patent number: 10286156
    Abstract: The present invention relates to a monitoring device for monitoring operation of a drug delivery device and to a respective drug delivery device, wherein the monitoring device comprises: a fastening member (32) to releasably attach the monitoring device to an axially elongated housing (14) of the drug delivery device (10), a sliding member (40) shiftable relative to the fastening member (32) in an axial direction (1, 2) and being adapted to operably engage with at least one dose setting component (17, 18, 26) of the drug delivery device (10) to follow an axial displacement of the dose setting component (17, 18, 26) relative to the housing component (14), a first sensor arrangement (36, 46) for detecting a rotation of the dose setting component (17, 18, 26) relative to the fastening member (32), a second sensor arrangement (38, 48) for detecting an axial displacement of the sliding member (40) relative to the fastening member (32), and a processing member (34) coupled to the first and to the second sensor a
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: May 14, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Jasmin Groeschke, Alexander Allerdings, Jan-Peter Spengler, Christoph Dette, Matthias Scharf, Andreas Bode, Michael Schrack
  • Patent number: 10286155
    Abstract: A pen type drug injection device includes a housing, a dose dial member, a torsion spring fixed between the housing and the dial member such that energy is accumulated in the torsion spring upon rotation of the dial member relative to the housing, a drive member engaging a lead screw, a first clutch, and a second clutch. The first clutch couples the drive member and the housing, in a coupled state and allows relative rotation between them in a de-coupled state. The second clutch rotationally couples the drive member and the dial member in a coupled state and allows clockwise and anti-clockwise rotation between them in a de-coupled state. The second clutch includes a ratchet clicker with teeth having different tooth angles in the clockwise and the anti-clockwise direction, such that, in the de-coupled state, the teeth override each other with different resistance in opposite directions.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: May 14, 2019
    Assignee: Sanofi
    Inventors: Simon Lewis Bilton, David Aubrey Plumptre, Matthew Jones, Joseph Butler
  • Patent number: 10281804
    Abstract: An image processing apparatus includes a three-dimensional space information storage unit, a projection unit, an operation acquisition unit, a reference guide rail decision unit, and a motion vector calculation unit. The projection unit projects and draws a cross-sectional plane onto a projection plane on the basis of information on a position of the cross-sectional plane stored by the three-dimensional space information storage unit. The reference guide rail decision unit decides a reference guide rail on the basis of information on a position of a slide operation acquired by the operation acquisition unit.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 7, 2019
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Hiroyuki Yamahara, Ankit Sharma, Armand Simon Alymamy Girier, Yeonsoo Yang
  • Patent number: 10272204
    Abstract: The present invention is directed to a drug delivery device comprising a cartridge with a movable bung, a drive mechanism including a bearing for driving the bung in a distal direction for delivering a medicament and a piston rod for actuating the bearing. An electric conductor for transmitting an electrical signal is provided, wherein the electric conductor is configured such that a conductive connection is established or interrupted when the piston rod contacts the bearing or when the bearing contacts the bung. The invention is further directed to a method for detecting the contact between the drive mechanism and the movable bung.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: April 30, 2019
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Jugl, Axel Teucher
  • Patent number: 10265478
    Abstract: An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose set direction (105) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction (106) opposite to the dose set direction (105).
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 23, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Garen Kouyoumjian, Robert Veasey, David Plumptre, Christopher Jones, Catherine Anne MacDonald, James May
  • Patent number: 10245384
    Abstract: An optical decoding system including an optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device and a processor configured to: (i) cause the optical sensor to capture images of the first and second rotatable components at least at the beginning and end of a medicament dose dispensing process; (ii) determine a rotational position of both the first and second rotatable components in each of the captured images; and (iii) determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by the dose setting and dispensing mechanism of the drug delivery device.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: April 2, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Markus Ploch
  • Patent number: 10213554
    Abstract: A medial assembly comprises a logging first unit adapted to be mounted on a drug delivery device second unit from a fully un-mounted to a fully mounted position along a path. The first unit comprises a switch operatable between an off- and an on-state when the first unit is mounted on the second unit, the switch being in the on-state when the first unit is mounted within a first distance from the fully mounted position, and in the off-state when the first unit is mounted outside the first distance from the fully mounted position, and a snap lock operatable from an initial state through an expanded state to a snap-in state when the first unit is mounted on the second unit, the snap lock being in the snap-in state when the first unit is mounted within a second distance from the fully mounted position, the second distance being shorter than the first distance. By this arrangement it is ensured that the switch will be in the on-state before the snap lock is in the snap-in state.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: February 26, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Jens Christian Andersen, Preben Mikael Nielsen, Nikolaj Eusebius Jakobsen, Nikolaj Frogner Krusell
  • Patent number: 10207056
    Abstract: A set of members for a drug delivery device comprises at least two components for the device, wherein both components are provided with a marking, the markings being substantially equivalent or identical. Furthermore, a drug delivery device and a set of drug delivery devices are provided.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: February 19, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Richard James Vincent Avery, Christopher Nigel Langley, James Alexander Senior, James Alexander Davies
  • Patent number: 10195359
    Abstract: The invention relates to a torsion spring driven injection device having a dial-down mechanism for dialling down a selected dose size. The torsion spring (2) is strained when setting a dose by rotating a proximally located dose setting button(30) relatively to the housing in a first direction and unstained when rotating the same dose setting button (30) in a second direction opposite the first direction. In order to secure the torsion spring (2) in its strained position a one-way ratchet mechanism is provided. This one-way ratchet mechanism comprises a fixation element (1) coupled to the housing and having a toothing (6) and a ratchet element (20) having at least one ratchet arm (22) engaging the fixation element (1) and which ratchet element (20) is operational coupled to the dose setting button (30).
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 5, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Simon Munch Pedersen, Simon Roervig
  • Patent number: 10183120
    Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring a volume or number of doses remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a light guide disposed and configured to reflect electromagnetic radiation toward the container. The dose measurement system also includes a light guide disposed and configured to emit electromagnetic radiation into the light guide. A plurality of sensors are located in the apparatus that are optically coupleable to the light guide and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light guide. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: January 22, 2019
    Assignee: Common Sensing Inc.
    Inventors: Kevin Sihlanick, Richard Whalley, Matthew Legrand, James White, Jeffrey Carothers
  • Patent number: 10149947
    Abstract: A drug delivery device for setting and dispensing of a dose of a medicament includes a housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal axial direction. The drug delivery device further includes a drive spindle operably engageable with the piston rod during dose dispensing and a drive member axially displaceable relative to the drive spindle against the action of a spring element during dose setting and being threadedly engaged with the drive spindle to form a spindle gear.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: December 11, 2018
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10143830
    Abstract: A injection site information cap includes a housing, a cover portion, an engagement portion configured to couple to and cover an injection port of an injection site, and at least one information element on the cover portion that is positioned to be automatically sensed by at least one sensor of the injection site when the engagement portion is coupled to or is being coupled to the medication injection port. Related apparatus, systems, and techniques are also described.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 4, 2018
    Assignee: CRISI Medical Systems, Inc.
    Inventor: Walter John Bochenko
  • Patent number: 10130514
    Abstract: Embodiments of the invention provide systems and methods for delivering therapeutic compositions to the inner-ear to treat inner-ear disorders. An embodiment of such a system comprises a sheath for insertion into the auditory canal and a cannula which can be inserted through the sheath. The cannula can include a tip for piercing the tympanic membrane and delivering the composition to an inner-ear tissue surface. The system may also include a therapeutic composition comprising a therapeutic agent and a thixotropic material which allows the composition to be delivered (e.g., by injection) through the cannula in liquid form and transition to gel-form once delivered to the tissue surface. A method for using the system comprises introducing the sheath into the ear, introducing the cannula through the sheath to pierce the tympanic membrane and position the tip adjacent an inner-ear tissue surface; and delivering the composition through the cannula to adhere to the tissue surface.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: November 20, 2018
    Assignee: InCube Labs, LLC
    Inventors: Mir Imran, Joel Harris
  • Patent number: 10130775
    Abstract: A medicament delivery device includes a housing having distal and proximal ends along a longitudinal axis. The housing is arranged to accommodate a medicament container and a delivery member connected to the container; a reloadable drive mechanism for acting on an accommodated container; a delivery member cover at the proximal end and slidable in relation to the housing along the axis; and a cover lock mechanism that includes a first lock member on an actuator movably arranged in relation to the housing and a second lock member on the cover. The first lock member engages the second lock member to block movement of the cover, and the actuator is movable in relation to the cover such that manually actuating the actuator generally transverse to the axis causes the first lock member to be moved out of engagement with the second lock member, thereby allowing the cover to be moved.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: November 20, 2018
    Assignee: Carebay Europe Limited
    Inventor: Stefan Högdahl
  • Patent number: 10124119
    Abstract: An injection device includes a housing having an aperture or window, and a dose indicator positioned within the housing. The dose indicator is rotatable with respect to the housing during dose setting and dose dispensing. The device includes a gauge element interposed between the housing and the dose indicator. The gauge element has a second aperture or window, which is positioned with respect to the first aperture or window such that at least a part of the dose indicator is visible through the first and second apertures or windows. The gauge element is axially guided within the housing and is in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element. A resilient member provides a force necessary for ejecting a dose from the injection device.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 13, 2018
    Assignee: Sanofi
    Inventors: Matthew Jones, Simon Lewis Bilton
  • Patent number: 10117998
    Abstract: An assembly for a drug delivery device is provided, the assembly comprising an actuator which is configured to perform a setting movement in a proximal direction in order to set a dose of a drug, and which is configured to perform a dispense movement in a distal direction in order to dispense a dose of a drug. The assembly further comprises stop mechanism acting after a maximum amount of a drug has been delivered, which is configured to axially constrain the setting movement of the actuator such that the setting of a dose is inhibited, wherein a limited axial movement of the actuator is allowed.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: November 6, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Jugl, Axel Teucher
  • Patent number: 10112017
    Abstract: A drug delivery device comprises a body component located concentrically within a sleeve, wherein the body component comprises body component thread features and the sleeve comprises sleeve thread features that engage with the body component thread features such that the body component is caused to rotate within the sleeve as the body component and the sleeve component move axially with respect to one another by force of an engaging face of the sleeve thread features against an engaging face of the body component thread features causing sliding of the engaging face of the sleeve thread features over the engaging face of the body component thread features. One of the body component and the sleeve constitutes a first part and the other of the body component and the sleeve constitutes a second part.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: October 30, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Richard Mercer, George Cave, Paul Richard Draper, Samuel Steel
  • Patent number: 10105498
    Abstract: A drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drug delivery device includes a dose indicating mechanism including a first spool and a second spool rotatably supported in the housing and a dose indicating tape coiled onto at least the second spool and fixed with an end to an outer circumference of the first spool. The first and second spools are oriented substantially parallel to each other and substantially parallel to the piston rod.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: October 23, 2018
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10105528
    Abstract: A medical device accessory comprising an interface configured to connect the medical device accessory with a medical device for administration of a medical treatment using the medical device and the medical device accessory, a plurality of electrical contacts proximate the interface, the electrical contacts comprising a lead electrical contact adapted to receive an voltage from a power source associated with the medical device and one or more identifying electrical contacts, and at least one conductor providing an electrical connection between the lead electrical contact and the one or more identifying electrical contacts. An arrangement of the one or more identifying electrical contacts connected to the lead electrical contact identifies a characteristic of the medical device accessory.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 23, 2018
    Assignee: Northgate Technologies Inc.
    Inventors: Robert Mantell, Chip Curtis, Steven Weaver, Eric Andersen
  • Patent number: 10105496
    Abstract: An automatic injector includes a cover extending along a longitudinal axis. A syringe for injecting a drug is arranged inside the cover, and includes a needle, a needle protector, a body, a plunger, and a rod for pushing the plunger into the syringe body, which is moved axially forwards by a resilient load force exerted by a first spring during an injection. The syringe also includes a tip for protecting the needle, which is axially movable about the needle and against a resilient load force exerted by a second spring between a forward position in which the tip surrounds the needle and a retracted position in which the needle is uncovered. A mechanism blocks the forward movement of the rod. The mechanism is deactivated as the tip is moved towards the retracted position and is reactivated during the injection when the tip is moved towards the forward position.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: October 23, 2018
    Assignee: Biocorp Production
    Inventor: Antoine Aneas
  • Patent number: 10058655
    Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: August 28, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Hardy Kietzmann, Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Matthias Scharf, Christoph Dette, Michael Schrack, Olaf Zeckai
  • Patent number: 10049189
    Abstract: The method set out herein involves conducting clinical trial to develop parenteral therapeutic product with drug delivery device. The method comprises conducting a dose-finding clinical study using a variable dose drug delivery device to evaluate multiple clinical doses, wherein the variable dose drug delivery device is automatic, portable and for user self-administration. During the dose-finding clinical study, both the performance of the drug and the performance of the variable dose drug delivery device are evaluated.
    Type: Grant
    Filed: September 19, 2015
    Date of Patent: August 14, 2018
    Inventor: Min Wei
  • Patent number: 10040084
    Abstract: A fluid dispenser comprising: a fluid reservoir (1); and a pump (3) comprising a pump body (30) and an actuator rod (34), defining between them a pump chamber (33) having a predetermined maximum volume, the rod (34) being axially movable in the body (30) so as to vary the volume of the pump chamber (33); the dispenser being characterized in that it further comprises a dispenser cannula (5) that is mounted on the actuator rod (34) and that includes a dispenser outlet (52) that is suitable for forming a drop of fluid that separates from the cannula (5) by gravity, the determined maximum volume of the pump chamber (33) being substantially equal to the volume of the drop of fluid that is dispensed at the dispenser outlet (52).
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: August 7, 2018
    Assignee: APTAR FRANCE S.A.S.
    Inventors: Frédéric Duquet, Sandra Martins-Reis, Francis Moreau
  • Patent number: 10016580
    Abstract: Methods and devices to quickly and accurately apply medication to a paranasal sinus are disclosed. Additionally, the methods and devices prevent the medication applied to a paranasal sinus from flowing down a patient's throat by expanding, using an inflation lumen of a device, an expandable member of the device adjacent to the patient's choana.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: July 10, 2018
    Assignee: Biovision Technologies, LLC
    Inventors: Stephen W. Chandler, David W. Sanso
  • Patent number: 9999751
    Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: June 19, 2018
    Assignee: CATHETER PRECISION, INC.
    Inventors: Robert Pacheco, Steve Foley, David Jenkins, Brandon D. Guarino
  • Patent number: 9987433
    Abstract: An assembly for a drug delivery device (200) is presented which comprises a housing (24) having a proximal end (25) and a distal end (26), a cartridge, a plunger (19) which is movably retained in the cartridge (14) and a piston rod (6). The assembly further comprises a rod displacement feature (33). The assembly is configured such that, in an initial state of the assembly, the piston rod (6) and the rod displacement feature (33) are arranged such that movement of the rod displacement feature (33) from the first position to the second position is transferred to the piston rod (6) such that the piston rod (6) is moved with respect to the cartridge (14) and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature (33) from the first position to the second position is not transferred to the piston rod (6).
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: June 5, 2018
    Assignee: Sanofi
    Inventors: Tom Oakley, Matt Schumann, Stuart Milne
  • Patent number: 9950110
    Abstract: An optical sensor for a delivery device having a piston that displaces a substance, such as a fluid, from a reservoir. The optical sensor has a light source and a detector array for imaging encoding features disposed along a plunger rod coupled to the piston. By virtue of the pattern of encoding features, an absolute position of the plunger rod relative to a fiducial position may be determined uniquely. Thus, the volume of fluid remaining in the reservoir, the rate of fluid delivery, and proper loading of the reservoir may be accurately ascertained. Additionally, the encoding may serve to uniquely identify a version of the reservoir which may be supplied in various versions corresponding, for example, to differing concentrations of a therapeutic agent to be dispensed.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 24, 2018
    Assignee: EUGLY DIABETES CARE LLC
    Inventors: Marc A. Mandro, Larry B. Gray
  • Patent number: 9950117
    Abstract: A cartridge engageable with a medical device, the method of making a cartridge comprising an ordered arrangement of N electrical components each with different respective values of an electrical property, and an ordered arrangement of N conductors operably coupled to the ordered arrangement of the N electrical components. A medical device is arranged to receive a cartridge comprises for each of N conductors on the cartridge, at least a first respective contact arranged to electrically couple with the corresponding conductor when the cartridge is engaged with the medical device; the medical device also comprises an evaluation means operable to evaluate the different respective values of an electrical property of N electrical components on the cartridge, wherein the N electrical components form an ordered arrangement which is operably coupled to the N conductors on the cartridge, and a switching arrangement operable to selectively electrically couple a respective pair of contacts to said evaluation means.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: April 24, 2018
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Rasmussen, Bo Erik Lennart Berggren, Bodo von Muenchow
  • Patent number: 9925339
    Abstract: A counter system for use in a drug delivery device is provided. The counter system comprises a counter element which is a foil, the counter element comprising indentations and indicia associated with the indentations, and a drive member provided with a catch for driving the counter element, wherein the catch engages a first indentation, and wherein, the catch is configured such that, when the drive member moves in a first direction, the counter element does not move and the catch disengages the first indentation and engages a second indentation which is arranged adjacent to the first indentation, and when the drive member moves in a second direction which is opposite to the first direction, the counter element also moves in the second direction.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: March 27, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Jugl, Axel Teucher
  • Patent number: 9907914
    Abstract: An assembly for a drug delivery device includes a guide track and a spring member. A first section of the guide track defines an angular start position for a guide feature of the dose member and a second section of the guide track defines an axial stop position for the guide feature. When the dose member is rotated in a dose setting direction, the guide feature is angularly displaced from the angular start position towards a connection region of the guide track, the spring member is torsionally biased by the spring member towards the angular start position. When the guide feature passes the connection region, the guide feature enters the second section and is axially displaced towards the axial stop position in which reduction of the torsional bias is prevented by mechanical cooperation of the guide feature and the second section.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: March 6, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Steffen Raab, Sandra Arnhold