Having Means For Metering Material Flow To Or From Body Patents (Class 604/207)
  • Patent number: 11969583
    Abstract: An injection device incorporating a dose setting mechanism is presented where the dose setting mechanism contains a fail safe feature that activates during an interrupted dose delivery event. A dose selector having a projecting rib engages a protrusion on a snap element to prevent the dose knob from moving distally if a user removes an axial force in the proximal direction during dose delivery. The dose setting mechanism can further include a reuse prevention feature.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: April 30, 2024
    Assignee: MEDMIX SWITZERLAND AG
    Inventors: Joachim Keitel, Herbert Bechtold
  • Patent number: 11969584
    Abstract: An injection device incorporating a dose setting mechanism is presented where the dose setting mechanism contains a dose selector having one or more dose stops corresponding to a finite set of predetermined fixed doses, where the set of finite predetermined fixed doses includes a lowest fixed dose and one or more higher fixed doses, and where at least one of the one or more higher fixed doses is equal to the lowest fixed dose plus a fractional amount of the lowest fixed dose. The dose setting mechanism can further include a floating spline that is rotationally engaged with a snap element such that the snap element can rotate relative to the floating spline during both dose setting and dose delivery.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: April 30, 2024
    Assignee: MEDMIX SWITZERLAND AG
    Inventor: Joachim Keitel
  • Patent number: 11931246
    Abstract: An intraocular lens implantation injector has a base body and elongated actuation element projecting into a base body rear section, movably guided along an actuation axis. Actuation element movement is generated selectively by axial push actuation or screw actuation about the axis. The actuation element features an external thread at least on one section. A switch element arranged to the base body is rotatable about or displaceable along the axis. The switch element features a spring arm, having an inner surface thread engagement structure facing the external thread. The base body inner surface forms an operative contact with a spring arm outer surface. The inner and/or outer surface is angularly inclined to the axis, or the inner surface features an inner radius varying circumferentially at least in sections about the axis. Switch element rotation/displacement generates spring arm elastic deformation towards/away from the axis, for selective thread engagement structure engagement.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: March 19, 2024
    Assignee: OPHTHALMO PRO GMBH
    Inventor: Alexander Bayer
  • Patent number: 11931556
    Abstract: The present invention provides a drug injection device (100, 100?, 100?) comprising a first element (130) and a second element (102, 102?, 102?) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (100, 100?, 100?), wherein the first element (130) comprises serially disposed protrusions (133), and wherein the second element (102, 102?, 102?) comprises a second element base and a deflectable transducer (170, 170?, 170?). The deflectable transducer (170, 170?, 170?) defines a base portion attached to the second element base, and a deflectable portion (162) configured for sequentially cooperating with the plurality of protrusions (133), wherein a processor (165) is electrically connected with the deflectable transducer (170, 170?, 170?) to register activation signals.
    Type: Grant
    Filed: February 2, 2019
    Date of Patent: March 19, 2024
    Assignee: Novo Nordisk A/S
    Inventors: Nikolaj Eusebius Jakobsen, Per Einar Pontus Holm
  • Patent number: 11931245
    Abstract: An intraocular lens implantation injector has a base body and an elongated actuation element projecting into a base body rear section and movably guided along an actuation axis. Actuation element movement is generated selectively by axial push actuation or by a screw actuation about the axis. The actuation element features an external thread at least on one section. At least one spring arm arranged at the base body has an inner surface thread engagement structure facing the external thread. A switch element, interacting with the spring arm, is rotatably or displaceably arranged on the base body. The switch element interacts with the spring arm via an operative contact. At least one switch element inner surface and/or spring arm outer surface involved in the operative contact is angularly inclined to the axis. Switch element rotation/displacement generates spring arm elastic deformation towards/away from the axis, thereby engaging/disengaging the thread engagement structure.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: March 19, 2024
    Assignee: OPHTHALMO PRO GMBH
    Inventor: Alexander Bayer
  • Patent number: 11911767
    Abstract: Described are exemplary embodiments of a syringe identification system for use with a positive displacement pipette, such as a handheld powered positive displacement pipette. An exemplary syringe identification system may include a sensor, such as a color sensor, that is located at or near a distal end of the pipette and arranged such that the sensor is operative to read an identifying marking(s) on a syringe that has been installed to the pipette. The sensor may be a color sensor having an illumination source and configured to read a color code on the syringe. The color code may be usable to identify the syringe to the pipette.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: February 27, 2024
    Assignee: Mettler-Toledo Rainin, LLC
    Inventors: Richard Hill, Michael McNaul, Bob Wells, Simon Shakespeare, Matthew Newman
  • Patent number: 11896996
    Abstract: A method of depositing an extrudable substance onto a surface. The method comprises the step of delivering the extrudable substance from a cartridge to a flow-bypass assembly. The method further comprises the step of selectively controlling the flow-bypass assembly to purge air from the extrudable substance before the extrudable substance enters a delivery tube. The method further comprises the step of selectively controlling the flow-bypass assembly to deliver the extrudable substance from the flow-bypass assembly to a valve assembly via the delivery tube. The method further comprises the step of controlling flow of the extrudable substance from the valve assembly to a nozzle.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: February 13, 2024
    Assignee: The Boeing Company
    Inventor: John W. Pringle-Iv
  • Patent number: 11878150
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 23, 2024
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Muller
  • Patent number: 11872381
    Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: January 16, 2024
    Assignee: Sanofi
    Inventors: Michael Jugl, Stefan Blancke, Axel Teucher, Ralph Donald Quentin Collings, James Robert Coop, James Anthony West, Stephen Francis Gilmore, Daniel David Higgins, Mark Digby Teucher, Anthony Paul Morris, Matthew Meredith Jones, William Geoffrey Arthur Marsh, Samuel Keir Steel
  • Patent number: 11865318
    Abstract: The present disclosure relates to an injection device configured to expel a dose of a medicament, the injection device comprising: an elongated housing extending in a longitudinal direction, a piston rod movable relative to the housing in a longitudinal distal direction to exert a dispensing pressure onto a bung of a cartridge at least partially filled with an injectable medicament, a rod extension movably arranged on or in a distal end of the piston rod, a driver operably engaged with the piston rod and movable relative to the housing in a longitudinal proximal direction for setting of the dose and movable relative to the housing in the longitudinal distal direction for dispensing of the dose, and an adjuster arranged on or in the driver and operably engaged with the rod extension to move the rod extension in longitudinal direction relative to the piston rod.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: January 9, 2024
    Assignee: Sanofi
    Inventors: Michael Jugl, Stefan Blancke
  • Patent number: 11865314
    Abstract: A medicament delivery device includes a body having a proximal end and a distal end, in turn comprising a distal housing part, and a medicament container holder, adapted to receive a medicament container; a dose setting drum for setting a dose when rotated in a first direction and for delivering a dose when rotated in a second direction, and a drive drum sleeve selectively operably connectable to a piston plunger for delivering a dose.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: January 9, 2024
    Assignee: SHL MEDICAL AG
    Inventor: Anders Wieselblad
  • Patent number: 11850405
    Abstract: A supplementary device for attachment to a drug delivery device is provided. The device includes an attachment mechanism for coupling the supplementary device to the drug delivery device, an imaging arrangement for providing image data representing a captured image of one or more numbers present on a number sleeve of the drug delivery device and a processor arrangement. The processor arrangement is configured to receive the image data; perform optical character recognition on the image data to determine a quantity of a currently set dose of medicament; cause display of the quantity of the currently set dose; process the image data to identify one or more characteristics of the number sleeve; determine from the identified characteristics whether the currently set dose is a permitted dose; and if the currently set dose is not a permitted dose, cause an indication that the currently set dose is not a permitted dose.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 26, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Stephan Riedel
  • Patent number: 11844935
    Abstract: A sliding cover for a liquid delivery device, such as a cap (100) for a pen injector (200), incorporates a set of sensors including an optical sensor (110) with an output which changes during uncapping or capping motions on passing of a plunger (220) of the pen injector. This output is used together with a position sensor (120) to determine the position of the plunger along a cylinder (210) of the liquid delivery device. By monitoring changes in the plunger position, the quantity of dosages delivered by the liquid delivery device can be determined, displayed, stored and/or transmitted to an external device for further data processing or storage. Preferred implementations of the invention employ optical sensors with a converging beam (115), and/or position sensors employing linear potentiometer strips (132).
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: December 19, 2023
    Assignee: PATIENTS PENDING LTD.
    Inventors: Avraham Shekalim, Noam Peleg
  • Patent number: 11838029
    Abstract: This invention relates to multichannel signal processing systems using synchronous protocols I2S (Inter-IC Sound Bus) and SPI (Serial Peripheral Bus) for sequenced data exchange, and providing unified synchronization of processed data. The system and method for synchronously multiplexing data streams in the I2S or SPI formats involves transformation of a standard Left/Right Clock (LRCK) sampled pulse signal of the I2S format or a Chip Select (CS) pulse signal of the SPI format into a LRCLt signal comprising a time stamp code and start and end marker codes of the synchronization clock signal, LRCK or CS, respectively. The presence of the marker codes and the time stamp code enables to restore the pulse signal, LRCK or CS, respectively, in the process of data stream program processing and link each discrete sample to the time stamp.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: December 5, 2023
    Inventors: Vitali Anatolevich Sedou, Igor Vitalievich Sedov
  • Patent number: 11813439
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: November 14, 2023
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Müller
  • Patent number: 11759397
    Abstract: A pharmacy tray for medications and medical items for patient treatment is placed onto a shelf that carries a grid of optical presence sensors. The location and identification of each item in the tray is recorded on a digital inventory for that tray. At the patient treatment site each item taken is recorded and the remaining inventory is updated without scanning the items.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: September 19, 2023
    Assignee: S&SX-ray Products, Inc.
    Inventor: Norman A. Shoenfeld
  • Patent number: 11759575
    Abstract: An injection device includes an elongated housing extending along a longitudinal axis, a piston rod to operably engage with a piston of a cartridge filled with the medicament, a dose tracker selectively operably engageable with the piston rod, wherein the dose tracker is longitudinally displaceable relative to the housing from an initial position in a proximal direction towards at least a first activation position for setting of the dose and wherein the dose tracker is longitudinally displaceable relative to the housing in a distal direction from the at least first activation position towards the initial position for dispensing of the dose, a spring to urge the dose tracker in the proximal direction relative to the housing, an interlock to lock the dose tracker in the initial position relative to the housing, and a release member to release the interlock.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: September 19, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Helmer, Michael Schabbach, Julian Kersting
  • Patent number: 11752271
    Abstract: A drug delivery apparatus including a barrel to contain a substance, a piston slidable in the barrel, a supply circuit to provide input currents, an antenna affixed along the barrel to receive the input current, generate inductance with the piston, and provide output currents commensurate with a position of the piston along the piston course, and processing circuitry configured to receive the output currents, and determine a quantity of the substance inside the barrel based on the output currents.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: September 12, 2023
    Assignee: DESVAC
    Inventors: Olivier Boisdon, Christophe Thomas-Javid, Stephane Veyrent
  • Patent number: 11717615
    Abstract: A medicament delivery assembly comprises a delivery device configured to deliver medicament to a user, a communication accessory releasably coupled to the delivery device, and one or more sensors configured to sense a condition of the delivery device. The communication accessory may be configured to receive a first signal from the one or more sensors assembly and to send a second signal to an external device.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 8, 2023
    Assignee: Mannkind Corporation
    Inventors: Christopher Gregory, Geoffrey Jenkins, Matthew Johnson
  • Patent number: 11679191
    Abstract: A device and method are provided for monitoring access to a patient by a device that withdraws liquid from the patient and/or supplies liquid to the patient, via a flexible line. A vessel access can be monitored during an extracorporeal blood treatment for which the blood of a patient is withdrawn via a flexible arterial line having an arterial puncture cannula, and supplied to the patient via a flexible venous line having a venous puncture cannula. The monitoring device has a line guide for loosely guiding a line segment of the flexible line. By detecting a change in situation of the loosely guided line segment, a conclusion is made as to whether an incorrect vessel access has occurred.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: June 20, 2023
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Christopher Hauke, Lars Offermanns
  • Patent number: 11672923
    Abstract: A packaging assembly comprises a case configured to contain at least one injection device for delivering a medicament; a cooling unit configured to lower an internal temperature of the case; a processing arrangement; a device sensor configured to detect at least one injection device contained within the case, and to receive device storage information from the at least one detected injection device; and a data storage device. The processing arrangement is configured to record an injection history on the data storage device. The processor arrangement is configured to control the cooling unit to set an internal temperature of the case according to the received device storage information.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: June 13, 2023
    Assignee: Sanofi
    Inventor: Michael Helmer
  • Patent number: 11672918
    Abstract: A needle syringe has a plunger and a needle for filling and dispensing liquid from the cavity. The cavity has finger clip with movable locking pins. The plunger has at least one set of grooves corresponding to a specific dosage for the needle syringe, the specific dosage of the groove being demarked by a marking ledge that indicates a change to a deeper depth section of the groove. The locking pins are configured to rest in the at least one set of grooves, such that when the plunger is removed, the locking pins pass within a first shallow section of the groove, pass over the ledge, and continue to pass in the deeper depth section of the groove. When the plunger is depressed in a first partial dispensing movement, the locking pins pass in the deeper depth section of the groove until the plunger depression is temporarily locked when the locking pins reach the ledge, where the dose remaining in the cavity is the specific dosage.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: June 13, 2023
    Inventor: Mark Reyman
  • Patent number: 11642468
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: May 9, 2023
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Muller
  • Patent number: 11642469
    Abstract: A medication delivery device and/or dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having a dose setting system and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: May 9, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Michael Harms, Steffen Raab, Dominic George Webber, James Robert Howarth, Trevor John Beckett, Geoffrey Philip Gray, John David Cross
  • Patent number: 11612698
    Abstract: The present disclosure relates to a medication delivery device having a dose detection system and an associated control system configured to determine an amount of medication delivered from the medication delivery device based on the sensing of relative rotation within the medication delivery device. The relative rotation may occur between a dose setting member and an actuator and/or housing of the medication delivery device. The rotation sensing may involve piezoelectric sensing, more specifically repeatedly deforming a piezoelectric sensor with a mechanical force. The dose detection system may be a modular or integral component of the medication delivery device.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: March 28, 2023
    Assignee: Eli Lilly and Company
    Inventors: Joseph Edward Katuin, Sean Matthew Pszenny
  • Patent number: 11612695
    Abstract: The present disclosure relates to a drug delivery device, having a longitudinal axis and comprising a plunger movable along the longitudinal axis and a guide curve adapted to engage at least one part of the plunger so as to guide the plunger when the plunger is being released to move along the longitudinal axis.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: March 28, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Uwe Dasbach, Marc Schader, Michael Kneip, Matthias Rau, Peter Nober
  • Patent number: 11566931
    Abstract: Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: January 31, 2023
    Assignee: BIGFOOT BIOMEDICAL, INC.
    Inventors: Richard Whalley, James White
  • Patent number: 11565052
    Abstract: A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: January 31, 2023
    Assignee: Sanofi
    Inventors: Ralph Donald Quentin Collings, James Robert Coop, James Anthony West, Stephen Francis Gilmore, Daniel David Higgins, Mark Digby Teucher, Stefan Blancke
  • Patent number: 11553926
    Abstract: A compression device for freeing a ring trapped on a digit includes a rigid outer body. The rigid outer body includes a digit cavity extending from a cavity opening at a body proximal end of the body towards a body distal end of the body, a fluid inlet, and a fluid flow path fluidly connecting the fluid inlet to one or more inflation chambers positioned in the digit cavity. The body proximal end includes an upper portion, a lower portion, and two laterally spaced-apart side portions. At least one side portion is distally recessed as compared to the upper and lower portions to accommodate an interdigital fold. At least one flexible bladder lines the digit cavity, each flexible bladder defining at least one wall of one of the one or more inflation chambers.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: January 17, 2023
    Assignee: Ring Rescue Incorporated
    Inventors: Brad MacKeil, Mason Landry, Callum Thompson, Patrick Hennessey, Kevin Spencer, Robert Nicolas Pratt, William Dicke, Michael Brown
  • Patent number: 11554217
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: January 17, 2023
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 11547803
    Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising: a piston rod to operably engage with a piston of a cartridge to displace the piston in a distal direction during a dose dispensing action, at least one actuation member mechanically coupled with the piston rod to induce a distally directed displacement of the piston rod when actuated by a user, a control to ascertain at least one predefined condition of use, and at least one interlock member coupled with the control to mechanically obstruct displacement of the piston rod if the condition of use is not fulfilled.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: January 10, 2023
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Hardy Kietzmann, Jasmin Groeschke, Hanno Juhnke, Jan-Peter Spengler, Matthias Scharf, Christoph Dette, Michael Schrack, Olaf Zeckai
  • Patent number: 11534553
    Abstract: A method of providing and/or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 ?g/mL. The method further includes providing, on the injector, a plurality of indicia only at prescribed doses of 50 ?g, 100 ?g, 150 ?g and 200 ?g settable via the dose setter without indicia between said prescribed doses; and permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter, wherein the injector is configured to provide at least one audible feedback during the rotation.
    Type: Grant
    Filed: December 29, 2021
    Date of Patent: December 27, 2022
    Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Satyashodhan Babasaheb Patil, Sudeep Kumar Agrawal, Subhas Balaram Bhowmick, Prashant Kane
  • Patent number: 11534554
    Abstract: A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: December 27, 2022
    Assignee: NOVO NORDISK A/S
    Inventors: Carsten Schau Andersen, Dave Szakelyhidi, Jakob Oest Wielandt, Matthew William Haave, Blake Matsuzaki, Gregory A. Kirkos, Nikolaj Eusebius Jakobsen
  • Patent number: 11529471
    Abstract: A sliding cover for a liquid delivery device, such as a cap (100) for a pen injector (200), incorporates a set of sensors including an optical sensor (110) with an output which changes during uncapping or capping motions on passing of a plunger (220) of the pen injector. This output is used together with a position sensor (120) to determine the position of the plunger along a cylinder (210) of the liquid delivery device. By monitoring changes in the plunger position, the quantity of dosages delivered by the liquid delivery device can be determined, displayed, stored and/or transmitted to an external device for further data processing or storage. Preferred implementations of the invention employ optical sensors with a converging beam (115), and/or position sensors employing linear potentiometer strips (132).
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: December 20, 2022
    Assignee: PATIENTS PENDING LTD.
    Inventors: Avraham Shekalim, Noam Peleg
  • Patent number: 11524118
    Abstract: A dosing mechanism for an injection device includes a dose-setting element with a first element coupled thereto, which, during dose setting, is rotatable relative to a second element about a main rotation axis in a first direction and, during dose discharge, is fixed in rotation relative to the second element. The first and the second elements are coupled via a sleeve-shaped stop element, which forms a stop abutment. The dosing mechanism includes a stop, and the stop abutment, during the rotation of the first element in the first direction, executes a movement to a stop position where the stop abutment strikes the stop and prevents rotation of the first element relative to the second element in the first direction of rotation. The sleeve-shaped stop element is rotatable about a secondary rotation axis, which is offset parallel to or offset at an angle to the main rotation axis.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: December 13, 2022
    Assignee: Ypsomed AG
    Inventors: Susanne Schenker, Ursina Streit, Patrick Hostettler
  • Patent number: 11524116
    Abstract: A drug delivery device includes a housing and a movable member, which is arranged to be rotatable in an incrementing direction and a decrementing direction, the movable member being operatively coupled to an energy storage member and biased to rotate into the decrementing direction by energy stored or storable in the energy storage member. Rotation of the movable member in the incrementing direction increases the energy stored in the energy storage member. The drug delivery device also includes a locking system including a locking feature, a block feature, and a release member, wherein the locking feature is arranged to cooperate with the block feature to form a releasable locking interface configured such that, when the releasable locking interface is established, rotational movement of the movable member relative to the housing is blocked in the decrementing direction, and when the releasable locking interface is released, the movable member is rotatable in the decrementing direction.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 13, 2022
    Assignee: Sanofi
    Inventors: Joshua Bough, Rosemary Burnell
  • Patent number: 11497853
    Abstract: A liquid medicine administration device includes a prefilled syringe and a gasket biasing member assembly. The biasing member assembly includes: a gasket pressing member configured to press a gasket; a flange attachment member attached to the prefilled syringe; a biasing member housed between the pressing member and the flange attachment member; and an operating member including an engagement holding portion. The pressing member includes an engagement portion to be engaged with the flange attachment member. When the engagement holding portion is located at an abutment position, deformation of a deformable portion is inhibited by abutment between the engagement holding portion and an abutment portion of a deformable portion, and engagement between the engagement portion and the attachment member body portion is held.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 15, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Masafumi Takemoto
  • Patent number: 11497854
    Abstract: A system comprises a first member, a second member, and a third member, wherein the first and second members are rotatable relative to the third member, wherein the first and second members are coupled to one another by a dead-angle follower coupling, wherein the dead-angle follower coupling is configured such that the first and second members are rotatable relative to one another, wherein the second and third members are rotationally coupled to one another by a switchable coupling mechanism, wherein the switchable coupling mechanism is switchable between two different states, a locked state and a non-locked state, wherein the maximum torque transferable between the second and third members via the switchable coupling mechanism in the locked state is greater than in the non-locked state, wherein the switchable coupling mechanism is in the locked state when the first member is in a locking position relative to the second member.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 15, 2022
    Assignee: Sanofi
    Inventors: Ralph Donald Quentin Collings, James Robert Coop, James Anthony West, Stephen Francis Gilmore, Daniel David Higgins, Mark Digby Teucher, Stefan Blancke
  • Patent number: 11491281
    Abstract: A drug delivery device includes a housing and a movable member, which is arranged to be rotatable in an incrementing direction and a decrementing direction, the movable member being operatively coupled to an energy storage member and biased to rotate into the decrementing direction by energy stored or storable in the energy storage member. Rotation of the movable member in the incrementing direction increases the energy stored in the energy storage member. The drug delivery device also includes a locking system including a locking feature, a block feature, and a release member, wherein the locking feature is arranged to cooperate with the block feature to form a releasable locking interface configured such that, when the releasable locking interface is established, rotational movement of the movable member relative to the housing is blocked in the decrementing direction, and when the releasable locking interface is released, the movable member is rotatable in the decrementing direction.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: November 8, 2022
    Assignee: Sanofi
    Inventors: Joshua Bough, Rosemary Burnell
  • Patent number: 11484658
    Abstract: A drug delivery device comprising: a housing; a cylindrical member rotatably supported within the housing; and a plurality of sensors; wherein: the outer surface of the cylindrical member is provided with a single track, the track forming an encoder and having a plurality of first track segments and a plurality of second track segments arranged along the length of the track which are respectively capable of inducing first and second responses in the sensors; and in each rotational position of the cylindrical member relative to the housing at least one different first track segment is capable of inducing a first response in at least one said sensor, thereby enabling the rotational position of the cylindrical member relative to the housing to be determined.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: November 1, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Samuel Keir Steel, Paul Richard Draper, George Cave
  • Patent number: 11484653
    Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: November 1, 2022
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Matthew Ekman, Timothy Donald Barrow-Williams, Yannick Hourmand
  • Patent number: 11478586
    Abstract: Methods for using precision low-dose, low-waste syringe configurations, which may have a reduced diameter lumen for dispensing 0.01 ml increments of contents. Methods may employ ergonomic attachments that improve the control and precision of the syringe. An attachment main body includes a gripping surface to permit a user to engage the attachment and move the attachment main body, and thus the syringe plunger relative to the syringe barrel using sliding movement. Methods may employ an assist feature on the attachment, which may be a traction wheel. Methods for using syringes with contents of higher viscosity may employ a pair of toothed pinion gears on a wheel and which cooperate with respective toothed racks formed on or fastened to the syringe body.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: October 25, 2022
    Assignee: Innomed Technologies, Inc.
    Inventors: John H. Joseph, Minh Bui, Rod Peterson
  • Patent number: 11458254
    Abstract: An apparatus and method for adjusting an injection device for administering a substance that includes a device housing with an array of fastening points. The apparatus has at least two housing-like shells, each having at least one holding device and at least one blocking device for attaching to the housing. The holding device of a first shell can be attached to a fastening point, and the holding device of a second shell can be attached to a further fastening point. Upon attaching all of the plurality of housing-like shells to the housing, the blocking devices of the plurality of housing-like shells prevent the disengagement of the plurality of housing-like shells from the housing by blocking detachment of the holding devices from the fastening points. At least one of the housing-like shells comprises an electronic assembly and shell attachment to the housing activates the electronic assembly.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: October 4, 2022
    Assignee: Ypsomed AG
    Inventors: Lorenz Schmid, Peter Stettler, Urs Klötzli, Adrian Eich, Vinzenz Frauchiger
  • Patent number: 11439766
    Abstract: The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system comprises a module including a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes first gear teeth. The rotation sensor comprises a driven gear including second gear teeth. The second gear teeth are operatively received by the first gear teeth and are driven in rotation as the first gear teeth rotate during dose delivery. The rotation sensor is responsive to the rotation of the second gear teeth to detect the rotation of the dose setting member.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: September 13, 2022
    Assignee: Eli Lilly and Company
    Inventors: Matthew Thomas Antonelli, William Churchill Taliaferro Burke, Roy Howard Byerly, Russell Wayne Perkins, Kenneth Alan Ritsher, Elias Raad Samia
  • Patent number: 11400229
    Abstract: Drug delivery system comprising expelling means for expelling an amount of drug from a reservoir, the expelling means comprising dose setting means (11, 21, 122) allowing a user to set a dose to be expelled, and actuation means (123) for releasing the drug expelling means to expel the set dose. The dose setting means comprises a drive sleeve (22) adapted to be rotated to set a dose, and a rotatable driven member (21) arranged for being rotationally driven by the drive sleeve (22) in a slaved rotational movement by means of a torque transfer coupling between the drive sleeve (22) and the rotatable driven member (21). The system further comprises an electronically controlled capturing system for capturing data representing a property related to the amount of drug expelled from the reservoir by the expelling means, and switch means configured to initiate an action within the electronically con-trolled capturing system upon occurrence of the slaved rotational movement.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: August 2, 2022
    Assignee: Novo Nordisk A/S
    Inventor: Peter Lundholm Jensen
  • Patent number: 11389594
    Abstract: An assembly for a medication delivery device includes a body, a piston rod, rotatable with respect to the body, for setting a dose of a medication, and axially movable in a distal direction for delivering the set dose, wherein, in cross-section, the piston rod includes a plurality of ratchet teeth to enable rotation of the piston rod during setting of a dose, and a stop member secured against axial and rotational movement, wherein the stop member mechanically cooperates with the piston rod, wherein, when setting the dose, the piston rod becomes aligned with the stop member, and wherein, when delivering the set dose, the piston rod is moved in the distal direction towards the stop member such that the piston rod and the stop member abut at the end of the dose delivery operation and further distal movement of the piston rod is prevented after dose delivery.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: July 19, 2022
    Assignee: NORTON HEALTHCARE LIMITED
    Inventors: Christopher James Smith, Dale Marc Comley, Lee Thomas Smith
  • Patent number: 11383038
    Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: July 12, 2022
    Assignee: INSULET CORPORATION
    Inventors: David Nazzaro, Ian McLaughlin, Maureen McCaffrey, Simon Kozin, Jackie Mac
  • Patent number: 11357921
    Abstract: A method of verifying that a first unit and a second unit being mounted to each other are correctly paired, the first unit comprising a first visual identifier and the second unit comprising a second visual identifier, the method comprising the steps of (i) capturing an image of the first and second unit mounted to each, the image comprising both the first and the second visual identifier, and (ii) processing the captured image to (a) identify the first and the second visual identifier, and (b) determine whether the captured identifiers represent a predefined combination of visual identifiers to thereby verify the pairing.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: June 14, 2022
    Assignee: Novo Nordisk A/S
    Inventor: Michael Bech Reisenhus
  • Patent number: 11338092
    Abstract: An injection pen to deliver a predefined dose of substance according to a prescribed schedule is disclosed. The injection pen includes a first portion having a medicinal chamber and a removable cover. The medicinal chamber is coupled to a piston on one end and attachable to an injection needle on an opposite end. The removable cover includes a solution dispenser. The injection pen includes a second portion couplable to the first portion. The second portion includes an actuator coupled to the piston for actuating the piston in an injection. The actuator may be controlled by an electronic circuit board embedded within the injection pen to regulate the delivery of a substance in the medicinal chamber based on a prescribed dose and injection schedule.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: May 24, 2022
    Inventor: Rundeep Gadh
  • Patent number: 11338093
    Abstract: An injection device comprises a housing having a longitudinal axis, an axially-depressible dose button (430), a dose indicator (418), a dose setting mechanism operatively coupled to said dose indicator and capable of setting a dose to be ejected from the injection device and spring capable of storing energy necessary for ejecting the dose from the injection device. The spring (420) is coupled to the dose setting mechanism such that a charging force can be transferred from the dose setting mechanism to the spring to increase the energy stored by the spring.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: May 24, 2022
    Assignee: Norton Healthcare Limited
    Inventors: Karl James Hewson, Jeremy James Robert Kooyman, Xorge Castro Pelayo