Including Means For Controlling Piston Stroke Length Patents (Class 604/208)
  • Patent number: 10350359
    Abstract: A dosing device for an injection device, the dosing device including an actuating element for adjusting and/or dispensing a dose from the injection device, a thrust element for generating a forward movement for discharging a dose and a coupling to which the actuating element and the thrust element are coupled such that a rotational movement of the actuating element is transmitted directly to the thrust element and an axial movement of the actuating element is different than an axial movement of the thrust element.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: July 16, 2019
    Assignee: TecPharma Licensing AG
    Inventors: Stefan Burren, Jürg Hirschel, Samuel Martinoia, Ulrich Moser, Markus Tschirren
  • Patent number: 10328211
    Abstract: An automatic accurate dose syringe includes a barrel, a plunger seal, a barrel adapter assembly having a barrel tip and a needle, and a dose control mechanism having a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. The syringe further includes a locking mechanism, an activation button, and a biasing member such as a compression and/or a torsional spring. The components are configured such that actuation of the activation button by the user manipulates the locking mechanism to permit the biasing member to move from an initial energized state to a lower energy state, thereby automating drug delivery from the syringe.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 25, 2019
    Assignee: UNL Holdings LLC
    Inventors: Gautam N. Shetty, Lou Castagna
  • Patent number: 10328209
    Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprises a housing (10) with a main axis (X), a dose setting member (2) being rotatable with respect to the housing (10) for setting a dose of a drug, an activation member (1) being axially movable with respect to the housing (10) for dispensing the dose from the drug delivery device, and a rotation member (5) being arranged between the activation member (1) and the dose setting member (2). The assembly (100) is configured such that the rotation member (5) is rotatable with respect to the dose setting member (2) and the activation member (1), wherein the outer surface (21) of the assembly (100) comprises the outer surface (22) of the rotation member (5).
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: June 25, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Torsten Kraft, Markus Oschmann
  • Patent number: 10307541
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drive mechanism further includes a last dose sleeve rotatably supported in the housing and being selectively engageable with a dose setting mechanism for setting of a dose, and a last dose member threadedly engaged to the housing, rotatably locked to the last dose sleeve and axially displaceable relative to the last dose sleeve.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: June 4, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10300212
    Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 28, 2019
    Assignee: ANTARES PHARMA, INC.
    Inventors: Janice L. Cox, Matthew H. Rust, Thomas E. Kramer, Peter A. Hoeft
  • Patent number: 10265480
    Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 23, 2019
    Assignee: DR. PY INSTITUTE LLC
    Inventor: Daniel Py
  • Patent number: 10238808
    Abstract: An injection device includes a housing, a resilient member adapted to provide a force necessary for ejecting a dose from the injection device, and a dose setting member operatively connected to a dose indicator which is positioned within the housing. The dose setting member and the dose indicator cooperate to set the dose to be ejected from the injection device. The dose indicator, during dose setting, is adapted to undergo a mere rotational movement within the housing and relative to the housing.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: March 26, 2019
    Assignee: Sanofi
    Inventors: Matthew Jones, Simon Lewis Bilton
  • Patent number: 10240959
    Abstract: Devices, systems, and methods for volumetrically measuring syringe fluid are disclosed. In one aspect, a device for volumetrically measuring syringe fluid includes a reference plate, a flange adapter base attached at a first end of the reference plate for receiving a flange of a syringe, a plunger adapter disposed adjacent to a housing for receiving a plunger of the syringe, the plunger adapter being configured to slidingly move along a length of the reference plate, a displacement sensor disposed in the housing and configured to measure a displacement of the plunger adapter in relation to the flange adapter base as the plunger adapter is slid along the length of the reference plate, and a displacement conversion mechanism disposed in the housing and configured to convert the displacement measurement of the plunger adapter to a volumetric measurement in order to determine a volume of fluid the syringe has drawn in.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 26, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Stephen Eckel, Christopher Roberts, Chase Dubois, Jorge Martínez-Blat, John C. Pamplin
  • Patent number: 10220155
    Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: March 5, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Jacob Eiland, Christian Peter Enggaard, Claus Schmidt Moller, Tom Hede Markussen
  • Patent number: 10213560
    Abstract: An injection device includes a housing, a dose setting member being operable in a first direction to set a desired dose to be dispensed, and a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from a cartridge. Further, a first part and a second part of the injection device are provided, which are adapted to perform a relative rotational movement with respect to each other during dispensing of a dose, and which are adapted to provide a non-visual feedback signal to a user only at the end of dispensing of a set dose. The dose setting member is further operable in a second direction which is opposite to the first direction to cancel a set dose. A third part is movable between a dose setting or cancelling position and a dose dispensing position relative to the first part and/or the second part, which third part contacts the first part and/or the second part in its dose setting or cancelling position or in its dose dispensing position.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: February 26, 2019
    Assignee: Sanofi
    Inventors: Joseph Butler, Matthew Jones
  • Patent number: 10195357
    Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose exceeding an amount of liquid left in a cartridge of the drug delivery device. The device includes a housing, a dose selector for selecting a dose by rotation relative to the housing, a dosing element, and a releasable clutch for rotationally coupling the dosing element to the dose selector during dose selecting and for rotationally decoupling the dosing element from the dose selector during dose dispensing. The clutch includes a male spline, a corresponding female spline and a curved or inclined surface which is orientated such that re-engagement of the clutch guides the male spline into a predefined rotational orientation with respect to the female spline.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Karl Hewson, Stuart Milne, Mark Pawulski
  • Patent number: 10195358
    Abstract: The piston rod arrangement is in an assembled state before use and comprises a piston rod, a bung, which is intended to be driven by the piston rod, a body member, and a drive member. The piston rod is threadedly engaged with the body member, and the drive member is threadedly engaged with the piston rod and movable relative to the body member. A mechanism is provided defining unit steps of movement of the drive member and corresponding unit steps of movement of the piston rod. The piston rod is arranged in contact with the bung or at a distance from the bung that is less than a distance of one corresponding unit step of movement. When the piston rod, the bung and the drive member are assembled in the body member, the piston rod is advanced with respect to the body member towards the bung, until the piston rod is stopped by the bung. The drive member is rotated until the piston rod begins to advance again and the drive member is then stopped, and the piston rod is fixed at or near the position obtained.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 5, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Paul Richard Draper, David Richard Mercer, Naceur Rekaya, Paul Griffin, Robert Veasey
  • Patent number: 10166341
    Abstract: The invention relates to a medicament delivery device (100) having a a drive mechanism arranged to drive a plunger rod (12). A release button (4) is movable between an active and an inactive state, wherein the release button (4) in the active state allows the actuator (3) to move axially towards a proximal end position and wherein the release button (4) in the inactive state allows the actuator (3) can move axially towards the proximal end position or towards the distal end position.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: January 1, 2019
    Assignee: Carebay Europe Ltd
    Inventor: Anders Holmqvist
  • Patent number: 10149945
    Abstract: An injection device provides a casing which accommodates or forms a reservoir for a liquid drug; a plunger rod which can move relative to the casing in an axially forward direction to deliver the drug; and a dosing means which can move in the forward direction relative to the casing to prime the reservoir and which can rotate relative to the casing for selecting a dose to be injected. Rotation of the dosing means relative to the casing is prevented until a priming operation for priming the reservoir is completed. The dosing means comprises a dosing control means which is configured to enable rotation of the dosing means at the end of the priming stroke for selecting the dose and to prevent a rotation of the dosing means back into the position which the dosing means had at the end of the priming stroke relative to the casing.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 11, 2018
    Assignee: TECPHARMA LICENSING AG
    Inventors: Ulrich Moser, Jürg Hirschel, Markus Tschirren, Philipp Wälchli, Peter Stettler, Patrick Sackermann, Christian Schrul, Martin Berger, Nicolas Binggeli
  • Patent number: 10149946
    Abstract: An assembly for use in a drug delivery device includes a cartridge, a housing and a cartridge holder. The cartridge holder is releasably attached to the housing. The assembly includes a piston rod configured to move from a start position to an end position to dispense a dose of medication when the cartridge holder is attached to the housing, and the piston rod is configured to be reset to the start position when the cartridge holder is detached from the housing. The assembly further comprises a flexible element configured to axially fix the cartridge in the cartridge holder when the cartridge holder is attached to the housing. Furthermore, the assembly comprises a guiding element in threaded engagement with the piston rod. The flexible element is configured to fix the guiding element with respect to a housing of the drug delivery device when the cartridge holder is attached to the housing.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: December 11, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Andreas Bernert
  • Patent number: 10143805
    Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a dose setting member (120; 220) rotatably arranged at a proximal end of the housing (20) for setting of a dose, a base member (60; 260) having a proximally extending shaft portion (61; 261) at least partially enclosed by the dose setting member (120; 220), a last dose limiting member (140; 240) radially disposed between the dose setting member (120; 220) and the base member (60; 260) and having at least one radial stop (143; 243a, 243b) to limit a rotational displacement of the dose setting member (120; 220) relative to the base member (60; 260), wherein the last dose limiting member (140; 240) is rotatably locked but axially displaceable to one of the base member (60
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: December 4, 2018
    Assignee: Sanofi
    Inventors: Björn Wilden, Stefan Bayer, Philipp Zeitz, Wolfgang Pelzer
  • Patent number: 10130772
    Abstract: A handheld injection device includes a housing, a rotatable dose setting member and a power reservoir coupled to the dose setting member. Energy is stored in the power reservoir during rotation of the dose setting member. The injection device also includes a release member for receiving a force from a user and a rotatably arranged drive member engaging with a drive track of a piston rod. The device further includes a release clutch rotationally constrained to the housing and releasably engaging the drive member. The release clutch is positionable in a first axial position when the release member is in a dose setting position and in a second axial position when the release member is in a dose injection position. The axial position of the drive member within the housing remains constant when the release member is in its dose setting position and in its dose injection position.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 20, 2018
    Assignee: Sanofi
    Inventors: Joseph Butler, Matthew Jones, David Aubrey Plumptre, William Marsh, Robert Veasey
  • Patent number: 10124115
    Abstract: A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 13, 2018
    Assignee: ANTARES PHARMA, INC.
    Inventors: Kevin David Swanson, Julius Sund, Peter A. Hoeft, Patrick E. Madsen
  • Patent number: 10117996
    Abstract: A system comprising a state changing appliance and a drug delivery device, the state changing appliance comprising first interface means for rotationally locking to a first exterior portion of the drug delivery device, second interface means for rotationally locking to a second exterior portion of the drug delivery device, the first exterior portion and the second exterior portion being angularly displaceable relative to one another from a first relative position to a second relative position, which second relative position defines a set dose to be expelled by the drug delivery device, and limiter means for limiting a relative angular displacement between the first interface means and the second interface means.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: November 6, 2018
    Assignee: Novo Nordisk A/S
    Inventor: Mads Schenstroem Stefansen
  • Patent number: 10112016
    Abstract: A drive mechanism of a drug delivery device and a respective drug delivery device for setting and dispensing of a dose of a medicament are presented, where the drive mechanism has an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge containing the medicament, a dosing arrangement manually and axially displaceable relative to the housing for setting and dispensing of the dose, and an accessory drive operably engaged with the piston rod to support a manually operated dose dispensing displacement of the dosing arrangement.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: October 30, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Paul Richard Draper, Anthony Paul Morris, Stephen Francis Gilmore
  • Patent number: 10022501
    Abstract: A medicament delivery device includes a housing, a container holder in the housing, an axially movable plunger, and an energy accumulating member adapted for displacing the plunger. The container holder is configured to accommodate a medicament container that includes a first piston arranged inside an opposite end portion of the container and a second piston arranged inside an intermediate portion of the container. The plunger includes an outer plunger rod, an inner plunger rod at least partially inside the outer plunger rod, a biassing arrangement for actuating the inner plunger rod, and a locking arrangement that, in a first state, locks the biassing arrangement in an energy-storing position and, in a second state, releases the biassing arrangement from the energy-storing position to displace the inner plunger rod into the container holder.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: July 17, 2018
    Assignee: Carebay Europe, Ltd.
    Inventor: Stephan Olson
  • Patent number: 10010678
    Abstract: An assembly for the administration of a selected dosage of insulin or other medicaments from a cartridge by moving a plug guided in said cartridge, comprises an adapter assembly for adapting cartridges with different dimensions or contents. The adapter assembly comprises a first threaded element threaded with a thread lead and movable in a moving direction to move the plug, and a second threaded element threaded with a thread lead for setting a selected dosage, pivotably screwed to said first threaded element and limiting the movement of said first threaded element, and wherein said thread lead of said first element and said thread lead of said second threaded element are adapted to the dimensions and/or the contents of said cartridge.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: July 3, 2018
    Assignee: EMPERRA GMBH E-HEALTH TECHNOLOGIES
    Inventors: Janko Schildt, Florian Rühle
  • Patent number: 9861751
    Abstract: A medication administering device, to which a preparation syringe containing a preparation is mounted, and which administers a preparation to a living body, and comprises a main body; a cylindrical syringe holder that is provided to the main body and into which the preparation syringe is inserted from the rear end side; a cylindrical syringe cover that supports the preparation syringe on the inner peripheral face side, and into which the preparation syringe is inserted from the distal end side; an inner case that guides the syringe cover and is removably fitted together with the syringe cover; and a distal end cap that guides the main body and is removably fitted together with the main body, and moves in conjunction with the syringe cover during attachment to the main body.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 9, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Toshiaki Iio, Hidenori Watanabe, Seiji Kikuchi, Yukihiro Takabatake
  • Patent number: 9861749
    Abstract: The present disclosure relates to a drug delivery device, in particular pen-type injectors, wherein a number or pre-set doses can be administered. In particular, the present disclosure relates to such drug delivery devices, where a user may activate the dose injection process and wherein the user is still able to control the dose injection process even after a dose injection process has been activated. The process of injecting a dose is supported by some kind of energy storing means as well as by a force to be exerted by a user. Moreover, the disclosure characterizes by a reduced amount of mechanical components.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: January 9, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Philippe Nzike
  • Patent number: 9855388
    Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 2, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Malcolm Boyd, Richard Letham, David Plumptre, Robert Veasey, James May, Matthew Jones, Samuel Ghazaros
  • Patent number: 9789258
    Abstract: The present invention is directed at a dose setting mechanism for a drug delivery device, comprising an outer sleeve and an inner sleeve located at least partially within the outer sleeve wherein the outer sleeve is connected to the inner sleeve. To reduce noise excitations of the dose setting mechanism, at least one intermediate element is at least partially located in a clearance between the inner sleeve and the outer sleeve in such way that it reduces the relative movement of the inner sleeve and the outer sleeve along a play between the inner sleeve and the outer sleeve. The invention is further directed to a pen-type injector equipped with a respective dose setting mechanism.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 17, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Marc Holtwick, Michael Jugl, Axel Teucher
  • Patent number: 9775953
    Abstract: A mechanism for preventing setting of a dose, which exceeds the amount of a medicament in a reservoir in an injection device. The device can contain a threaded piston rod, a limiter and a driver. The three elements can be arranged such that during dose setting, the limiter is moved towards an end-of-content position, wherein dose setting is limited. The invention contains an accumulative and a non-accumulative embodiment. The invention further relates to a mechanism for preventing ejection of a dose exceeding the set dose.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 3, 2017
    Assignee: Novo Nordisk A/S
    Inventors: Christian Peter Enggaard, Claus Schmidt Moller, Tom Hede Markussen
  • Patent number: 9775952
    Abstract: A drug delivery device comprises a first component and a second component, wherein a substance is provided on at least one of the first component and the second component. An inner friction of the substance is great enough to stabilize at least one of the orientation and the position of the first component and the second component with respect to one another. The inner friction of the substance is small enough to allow relative movement of the first component and the second component necessary for the intended operation of the device. Furthermore, a method for assembling a drug delivery device is provided.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: October 3, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Noderer, Timothy Giles Claughton, Warren Terry, Robert Veasey
  • Patent number: 9744313
    Abstract: A nebulizer and a housing part comprising a blocking device as well as use of a blocking device are proposed. The blocking device blocks a rotatable element of a counter device in a defined rotational position until the nebulizer is closed.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: August 29, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jens Besseler, Frank Herrmann, Holger Holakovsky, Herbert Argauer, Josef Gatz, Andreas Gorshoefer
  • Patent number: 9717856
    Abstract: An injection apparatus includes a counter wheel that is incremented by the dose delivery mechanism each time the device is fired. The apparatus includes a final dose disabling mechanism that prevents further usage once the final dose has been delivered. An anti-tamper feature is provided to prevent inadvertent or premature initialisation of the apparatus.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: August 1, 2017
    Assignee: OWEN MUMFORD LIMITED
    Inventors: Clive Nicholls, Robert Michael Wozencroft, Jeremy Marshall
  • Patent number: 9717859
    Abstract: A medication delivery device and/or dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having a dose setting system and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge.
    Type: Grant
    Filed: July 23, 2016
    Date of Patent: August 1, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Harms, Steffen Raab, Dominic George Webber, James Robert Howarth, Trevor John Beckett, Geoffrey Philip Gray, John David Cross
  • Patent number: 9713677
    Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 25, 2017
    Assignee: SHL Group AB
    Inventor: Mattias Daniel
  • Patent number: 9707351
    Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: July 18, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: David Martin Leak, Joseph Butler
  • Patent number: 9669988
    Abstract: A fixed amount discharge container includes: a syringe barrel 3; and a piston 8 inserted in the syringe barrel 3 so as to be movable in a longitudinal direction, thereby defining a fluid chamber between the syringe barrel 3 and the piston 8. One of the syringe barrel 3 and the piston 8 includes a guide 3c that is extended in a longitudinal direction. The other of the syringe barrel 3 and the piston 8 includes a slider 9 that is movable in the guide 3c along with the other of the syringe barrel 3 and the piston 8. The guide 3c is provided with a target position contact portion 3j which the slider 9 contacts when an amount of the fluid chamber is equal to a target amount.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: June 6, 2017
    Assignee: Santen Pharmaceutical Co., LTD.
    Inventors: Takashi Kojima, Nobuo Yokouchi, Naoki Kato, Kenji Kaitsuka, Takeshi Iida
  • Patent number: 9649447
    Abstract: An assembly is presented having a reservoir holder, a dose setting mechanism, and flexible fastener configured to fasten the reservoir holder to the dose setting mechanism, wherein the flexible fastener is provided at one of the reservoir holder and the dose setting mechanism. The flexible fastener is configured to releasably fasten the reservoir holder and the dose setting mechanism to each other. Moreover, said flexible fastener is arranged on a retention ring provided at the one of the reservoir holder and the dose setting mechanism. Furthermore, a drug delivery device with such an assembly is disclosed.
    Type: Grant
    Filed: September 28, 2011
    Date of Patent: May 16, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Richard James Vincent Avery, Aled Meredydd James
  • Patent number: 9623189
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: April 18, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 9623199
    Abstract: The invention refers to an injection device comprising a delivery mechanism for injection of a medicament, preferably through a needle, and an end of dose mechanism comprising a feedback element, wherein the end of dose mechanism is operable to be activated at a position at which the delivery mechanism reaches the end of the dose and the end of dose mechanism is further operable to force the feedback element to move into a feedback direction which is opposite or parallel to the activation direction of a release button and/or into the longitudinal direction, wherein the activation direction is preferably a longitudinal direction of the device.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: April 18, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Frank Richter, Ross Macarthur
  • Patent number: 9610409
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: April 4, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 9604008
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: March 28, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 9572937
    Abstract: The invention relates to a clutch mechanism for the transmission of a rotary movement from a gear arrangement comprising a first gear member and a second gear member. The first gear member is rotatable about a longitudinal axis but axially fixed wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member which is prevented from rotating. The clutch mechanism comprises a circumferential shoulder arranged at the second gear member and at least one or a number of resilient clutch fingers with respective inclined inner surfaces arranged at the first gear member, the shoulder arranged for increasingly pressing against the inclined surfaces thereby flexing the clutch fingers outward when the shoulder reaches the clutch fingers in the course of its translation. The clutch mechanism further comprises tube arranged around the clutch fingers, the tube having a number of internal longitudinal splines for engaging the flexed-out clutch fingers.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: February 21, 2017
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Matthew Ekman, Timothy Donald Barrow-Williams, Yannick Hourmand
  • Patent number: 9561331
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: February 7, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 9561333
    Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: February 7, 2017
    Assignee: Antares Pharma, Inc.
    Inventors: Janice L. Cox, Matthew H. Rust, Thomas E. Kramer, Peter A. Hoeft
  • Patent number: 9533105
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: January 3, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 9533107
    Abstract: A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: January 3, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: David Plumptre, Andrew Mark Lindsay, Catherine Anne Macdonald, Robert Veasey, Christopher Jones, Garen Kouyoumjian
  • Patent number: 9533100
    Abstract: A method and system for priming a drug delivery device are provided. The drug delivery device includes a forced priming feature that requires the user to move the dose dial sleeve (3) axially to cause the spindle (5) to pre-load a cartridge bung before a first dose can be dialed.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: January 3, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Christopher Jones
  • Patent number: 9517308
    Abstract: A dose setting mechanism comprises a drug delivery device housing and a dual state track provided within the housing that is axially and rotationally fixed with respect to the housing. A dose dial component is positioned in the housing and rotatable during dose setting and dose delivery. A clutch is rotatable during dose setting and non-rotatable during dose delivery. A clutch plate is rotationally fixed relative to the housing; and a clutch blocker is in threaded engagement with the clutch plate and has a radial key engaged with the dual state track. The mechanism may comprise a biasing member positioned between the clutch blocker and clutch plate.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: December 13, 2016
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: David Moore, Joseph Butler, David Martin Leak
  • Patent number: 9517151
    Abstract: An apparatus and method for controlling inflation pressure and pressurization rate of a balloon during deployment of a stent or scaffold are disclosed. The apparatus and method involve a pressure attenuator for controlling an inflation rate of the delivery balloon.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: December 13, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Matthew Gillick, Yunbing Wang, Justin Mann, Bruce Wilson, James Oberhauser
  • Patent number: 9511193
    Abstract: An assembly for a drug delivery device, comprising a housing having a proximal end and a distal end, a piston rod and an indicator. The piston rod is adapted to be displaced distally with respect to the housing away from a proximal start position and towards a distal end position for delivering a drug. The indicator is adapted for indicating at least two different operation conditions of the assembly, the indicator being movable with respect to the housing from a first indication position for a first condition of the assembly into a second indication position for a second condition of the assembly. The piston rod and the indicator are configured to mechanically interact for converting movement of the piston rod into movement of the indicator. A first detent is provided which is configured to releasably secure the indicator in the first indication position such that movement into the second indication position is allowed.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: December 6, 2016
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: David Plumptre, Warren Terry, Robert Veasey, Matthew Jones, Timothy Giles Claughton
  • Patent number: 9486588
    Abstract: The present invention relates to a dose setting and expelling device comprising a drive member and a dose setting mechanism which simultaneously sets a given dose and stores the energy necessary for a subsequently driving the drive member in order to expel a dose of medicine from an injection device. According to the invention the dose setting mechanism allows adjustment in both directions, such that a given set dose can be reduced or cancelled by reversing the input motion, typically by rotating a setting member backwardly, this in contrast to the known devices which either requires an additional release mechanism or which cannot be reversed at all.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: November 8, 2016
    Assignee: Novo Nordisk A/S
    Inventor: Christian Peter Enggaard
  • Patent number: RE46814
    Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: May 1, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Christopher James Smith, Michael Heald, Stephen David Butler, Mark Philip Horlock