Including Means For Controlling Piston Stroke Length Patents (Class 604/208)
  • Patent number: 10729855
    Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: August 4, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
  • Patent number: 10702661
    Abstract: Disclosed is an injection device (1280) for injecting a hypodermic syringe (1260) along an injection direction defining an injection axis. The injecting device comprises a housing (1281) for being positioned at the skin and a movable element (1282) movably arranged relative to the housing between a retracted position and an injection position. The movable element comprises a hypodermic syringe holder (1289) for holding a hypodermic syringe. Disclosed is further a protective cover (1200) for a needle, and methods for arranging a hypodermic syringe in an injection device.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: July 7, 2020
    Assignee: UNION MEDICO APS
    Inventor: Michael Perthu
  • Patent number: 10702659
    Abstract: The present invention is generally directed to an assembly for a drug delivery device comprising a first threaded member (50, 50?), a second threaded member (40, 60?) with a longitudinal axis and a thread (61), having at least two consecutive portions (62, 63, 64) with different leads. The first threaded member (50, 50?) and the second threaded member (40, 60?) are adapted and arranged to rotate with respect to one another about the longitudinal axis of the second threaded member (40, 60?) during dose setting operation of the assembly, the first threaded member (50, 50?) thereby being axially displaced along the second threaded member (40, 60?) from a start position to an end position with respect to the second threaded member (40, 60?) due to the mechanical cooperation of the first threaded member (50, 50?) with the thread (61).
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: July 7, 2020
    Assignee: Sanofi
    Inventors: Anthony Paul Morris, Paul Griffin
  • Patent number: 10688248
    Abstract: An injection device includes a housing, a resilient member adapted to provide a force necessary for ejecting a dose from the injection device, and a dose setting member operatively connected to a dose indicator which is positioned within the housing. The dose setting member and the dose indicator cooperate to set the dose to be ejected from the injection device. The dose indicator, during dose setting, is adapted to undergo a rotational movement within the housing and relative to the housing. Further, a gauge element is provided which is rotationally constrained to the housing and axially displaceable relative to the housing. The gauge element and the dose indicator form a limiter mechanism defining a maximum settable dose and/or a minimum settable dose.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: June 23, 2020
    Assignee: Sanofi
    Inventors: Matthew Jones, Simon Lewis Bilton
  • Patent number: 10632262
    Abstract: This disclosure relates to a drive mechanism for a drug delivery device and to a respective drug delivery device. The drive mechanism includes an elongated housing extending in an axial direction, an actuation member rotatably supported on the housing for setting of the dose. The drive mechanism further includes a last dose sleeve directly rotatably engaged with the actuation member and having at least one stop and a last dose member threadedly engaged with the last dose sleeve. The last dose member is further rotatably fixed to the housing and is operable to engage with the at least one stop to limit a rotation of the last dose sleeve.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 28, 2020
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Michael Pfoser, Björn Wilden
  • Patent number: 10617826
    Abstract: An assembly for a drug delivery device is provided comprising a housing, and a lead screw having a longitudinal axis, a distal end and a proximal end, the lead screw being rotatably fixed during dose setting and dose delivery and axially movable in a distal direction relative to the housing, the lead screw further including a thread. The assembly further comprises a drive nut threadedly engaged with and screwable along the lead screw thread and a dial link connected with the drive nut and axially movable and rotatably fixed relative to the drive nut, where the dial link comprises a first portion of a feedback ratchet. The assembly is configured such that, during dose delivery, the assembly generates a feedback signal.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: April 14, 2020
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Stefan Blancke, Axel Teucher, Michael Jugl, Christiane Schneider
  • Patent number: 10603443
    Abstract: A driving and dosing device for an injection device for discharging a liquid product includes a housing, a rotatable dose adjustment member for adjusting a product dose to be discharged, a driven member received in the housing, a driving member rotatable relative to the housing and which, during the discharge of product, is coupled to the driven member such that a rotation of the driving member has the effect that the driven member is moved in the distal direction relative to the housing, a pretensioned driving spring which is switched between the dose adjustment member and the driving member during the adjustment of the product dose, wherein the dose adjustment member, during the adjustment of the product dose, is coupled in a rotationally fixed manner to the driving member, such that a rotation of the driving member relative to the dosing member is prevented.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: March 31, 2020
    Assignee: TecPharma Licensing AG
    Inventors: Susanne Schenker, Ursina Streit, Patrick Hostettler
  • Patent number: 10596332
    Abstract: the present invention relates to a device for a medicament delivery device, which extends along a longitudinal axis and comprises a medicament delivery member cover (18) arranged at a proximal end thereof; wherein the device comprises a delivery member protruding adjuster (28) operably connected to said medicament delivery member cover (18). The invention is characterised in that the device further comprises a signal generating mechanism (34) operably connected to said delivery member protruding adjuster (28) and arranged to provide an audible and/or tactile and/or visual signal indicating that a certain penetration depth has been set.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: March 24, 2020
    Assignee: SHL MEDICAL AG
    Inventor: Gunnar Elmen
  • Patent number: 10589029
    Abstract: An adjustable needleless injection system for subcutaneous injection of a liquid medication to a patient is disclosed. The adjustable needleless injection system may include: a medication cartridge that holds the liquid medication, where the medication cartridge includes a cartridge piston, a spring-actuated injector that may be coupled with the medication cartridge and configured to selectively apply force to the cartridge piston, and a charging mechanism configured to charge the spring-actuated injector based on a body type of the patient.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: March 17, 2020
    Inventor: Soheila Salahshoor Kordestani
  • Patent number: 10576212
    Abstract: The present disclosure is generally directed to a dose setting mechanism and a drug delivery device herewith, i.e. a handheld injection device for selecting and dispensing a number of user variable doses of a medicament. The dose setting mechanism comprises a dose setting member rotatable relative to a housing in a first direction for dose setting and in an opposite second direction for dose correcting, a cam ring and a coupling member coupled to a drive member. A ramped interface is provided between the dose setting member and the cam ring such that rotation of the dose setting member relative to the cam ring in the second direction causes axial displacement of the cam ring.
    Type: Grant
    Filed: February 8, 2015
    Date of Patent: March 3, 2020
    Assignee: Sanofi
    Inventors: William Geoffrey Arthur Marsh, Matthew Meredith Jones
  • Patent number: 10561796
    Abstract: Apparatus and methods for providing controlled pressure-flow pulses which purge a catheter system with turbulent flow flushing. Accomplishment of such controlled pressure-flow pulses is provided by a variety of inventive devices including a special plunger rod for a conventional syringe, other interactive parts for conventional syringes, an in-line catheter attachable device which automatically generates the controlled pressure-flow pulses and also single pulse, digitally operated devices.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: February 18, 2020
    Assignee: Beckton, Dickinson and Company
    Inventors: Michael W. Howlett, James V. Mercer, Amelio Paolucci
  • Patent number: 10549046
    Abstract: A drive mechanism (1) for use in a drug delivery device (100) is provided. The drive mechanism (1) comprises a housing (10, 11, 12, 14, 15) with a proximal and a distal end and a piston rod (22) which is rotatable with respect to the housing (10, 11, 12, 14, 15). The drive mechanism (1) further comprises a nut member (31) which is selectively rotationally lockable with respect to the housing (10, 11, 12, 14, 15), wherein the drive mechanism (1) is switchable between a setting mode of operation and a dispensing mode of operation.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: February 4, 2020
    Assignee: Sanofi
    Inventors: Simon Lewis Bilton, Robert Veasey, Matthew Jones, David Aubrey Plumptre, William Marsh, Michael Bainton, Daniel David Higgins
  • Patent number: 10507289
    Abstract: A medicament delivery device is presented having a housing, a medicament container holder, arranged movable in relation to the housing and capable of accommodating a medicament container. An activator is arranged in the housing and capable of, upon activation, acting on a medicament container for expelling a dose of medicament, where the activator has a plunger rod, a manually operable dose setting nut rotatably connected to the housing and arranged with first threads. Second threads are arranged on the medicament container holder being arranged to cooperate with said dose setting nut, wherein operation of the dose setting nut will cause the medicament container holder with the medicament container to move towards the plunger rod for setting a dose of medicament to be delivered.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: December 17, 2019
    Assignee: SHL MEDICAL AG
    Inventors: Kasper Enge, Gunnar Elmén, Anders Holmqvist
  • Patent number: 10471217
    Abstract: An assembly for a drug delivery device is provided, the assembly comprising a feedback feature. The feedback feature is configured to indicate an end of the dispense operation to a user by giving an audible and/or tactile feedback.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: November 12, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Naceur Rekaya, Paul Richard Draper, Paul Griffin, Stephen Francis Gilmore
  • Patent number: 10463801
    Abstract: A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 5, 2019
    Assignee: Sanofi
    Inventors: William Marsh, Anthony Paul Morris, Matthew Jones, Samuel Steel
  • Patent number: 10449301
    Abstract: An assembly for a drug delivery device is provided, the assembly comprising an actuator which is configured to be operated in order to dispense a dose of medication and a feedback feature being configured to give a feedback signal to a user at the end of a dwell period after the actuator has reached an end position.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 22, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Naceur Rekaya, Paul Richard Draper, Paul Griffin, Stephen Francis Gilmore
  • Patent number: 10357616
    Abstract: An injection device with a dose delivering mechanism being adapted to provide a non-visual, e.g. audible and/or tactile, feedback signal when a set dose has been at least substantially injected. A first and a second part of the injection device are adapted to perform a relative rotational movement with respect to each other. The relative rotational movement causes at least two parts of the injection device to abut or engage, and this abutment or engagement causes the non-visual feedback signal to be generated. A very distinct and precise feedback is provided as compared to prior art axial solutions because the generation of the feedback signal is initiated by the relative rotational movement. Feedback signal may be generated by a change in a rotational velocity of at least one part, e.g. by changing the pitch of a threaded portion or by engaging a non-rotating part and a rotating part, thereby causing the non-rotating part to start rotating.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: July 23, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Claus Schmidt Moller, Bo Radmer, Lars Ulrik Nielsen, Christian Peter Enggaard
  • Patent number: 10350359
    Abstract: A dosing device for an injection device, the dosing device including an actuating element for adjusting and/or dispensing a dose from the injection device, a thrust element for generating a forward movement for discharging a dose and a coupling to which the actuating element and the thrust element are coupled such that a rotational movement of the actuating element is transmitted directly to the thrust element and an axial movement of the actuating element is different than an axial movement of the thrust element.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: July 16, 2019
    Assignee: TecPharma Licensing AG
    Inventors: Stefan Burren, Jürg Hirschel, Samuel Martinoia, Ulrich Moser, Markus Tschirren
  • Patent number: 10328211
    Abstract: An automatic accurate dose syringe includes a barrel, a plunger seal, a barrel adapter assembly having a barrel tip and a needle, and a dose control mechanism having a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. The syringe further includes a locking mechanism, an activation button, and a biasing member such as a compression and/or a torsional spring. The components are configured such that actuation of the activation button by the user manipulates the locking mechanism to permit the biasing member to move from an initial energized state to a lower energy state, thereby automating drug delivery from the syringe.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 25, 2019
    Assignee: UNL Holdings LLC
    Inventors: Gautam N. Shetty, Lou Castagna
  • Patent number: 10328209
    Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprises a housing (10) with a main axis (X), a dose setting member (2) being rotatable with respect to the housing (10) for setting a dose of a drug, an activation member (1) being axially movable with respect to the housing (10) for dispensing the dose from the drug delivery device, and a rotation member (5) being arranged between the activation member (1) and the dose setting member (2). The assembly (100) is configured such that the rotation member (5) is rotatable with respect to the dose setting member (2) and the activation member (1), wherein the outer surface (21) of the assembly (100) comprises the outer surface (22) of the rotation member (5).
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: June 25, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Torsten Kraft, Markus Oschmann
  • Patent number: 10307541
    Abstract: A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drive mechanism further includes a last dose sleeve rotatably supported in the housing and being selectively engageable with a dose setting mechanism for setting of a dose, and a last dose member threadedly engaged to the housing, rotatably locked to the last dose sleeve and axially displaceable relative to the last dose sleeve.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: June 4, 2019
    Assignee: Sanofi
    Inventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
  • Patent number: 10300212
    Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 28, 2019
    Assignee: ANTARES PHARMA, INC.
    Inventors: Janice L. Cox, Matthew H. Rust, Thomas E. Kramer, Peter A. Hoeft
  • Patent number: 10265480
    Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: April 23, 2019
    Assignee: DR. PY INSTITUTE LLC
    Inventor: Daniel Py
  • Patent number: 10238808
    Abstract: An injection device includes a housing, a resilient member adapted to provide a force necessary for ejecting a dose from the injection device, and a dose setting member operatively connected to a dose indicator which is positioned within the housing. The dose setting member and the dose indicator cooperate to set the dose to be ejected from the injection device. The dose indicator, during dose setting, is adapted to undergo a mere rotational movement within the housing and relative to the housing.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: March 26, 2019
    Assignee: Sanofi
    Inventors: Matthew Jones, Simon Lewis Bilton
  • Patent number: 10240959
    Abstract: Devices, systems, and methods for volumetrically measuring syringe fluid are disclosed. In one aspect, a device for volumetrically measuring syringe fluid includes a reference plate, a flange adapter base attached at a first end of the reference plate for receiving a flange of a syringe, a plunger adapter disposed adjacent to a housing for receiving a plunger of the syringe, the plunger adapter being configured to slidingly move along a length of the reference plate, a displacement sensor disposed in the housing and configured to measure a displacement of the plunger adapter in relation to the flange adapter base as the plunger adapter is slid along the length of the reference plate, and a displacement conversion mechanism disposed in the housing and configured to convert the displacement measurement of the plunger adapter to a volumetric measurement in order to determine a volume of fluid the syringe has drawn in.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 26, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Stephen Eckel, Christopher Roberts, Chase Dubois, Jorge Martínez-Blat, John C. Pamplin
  • Patent number: 10220155
    Abstract: A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if the dose limiting mechanism fails, the safety mechanism prevents ejection of a dose exceeding the set dose.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: March 5, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Jacob Eiland, Christian Peter Enggaard, Claus Schmidt Moller, Tom Hede Markussen
  • Patent number: 10213560
    Abstract: An injection device includes a housing, a dose setting member being operable in a first direction to set a desired dose to be dispensed, and a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from a cartridge. Further, a first part and a second part of the injection device are provided, which are adapted to perform a relative rotational movement with respect to each other during dispensing of a dose, and which are adapted to provide a non-visual feedback signal to a user only at the end of dispensing of a set dose. The dose setting member is further operable in a second direction which is opposite to the first direction to cancel a set dose. A third part is movable between a dose setting or cancelling position and a dose dispensing position relative to the first part and/or the second part, which third part contacts the first part and/or the second part in its dose setting or cancelling position or in its dose dispensing position.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: February 26, 2019
    Assignee: Sanofi
    Inventors: Joseph Butler, Matthew Jones
  • Patent number: 10195357
    Abstract: A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a dose limiter for preventing the setting of a dose exceeding an amount of liquid left in a cartridge of the drug delivery device. The device includes a housing, a dose selector for selecting a dose by rotation relative to the housing, a dosing element, and a releasable clutch for rotationally coupling the dosing element to the dose selector during dose selecting and for rotationally decoupling the dosing element from the dose selector during dose dispensing. The clutch includes a male spline, a corresponding female spline and a curved or inclined surface which is orientated such that re-engagement of the clutch guides the male spline into a predefined rotational orientation with respect to the female spline.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Sanofi
    Inventors: Tom Oakley, Karl Hewson, Stuart Milne, Mark Pawulski
  • Patent number: 10195358
    Abstract: The piston rod arrangement is in an assembled state before use and comprises a piston rod, a bung, which is intended to be driven by the piston rod, a body member, and a drive member. The piston rod is threadedly engaged with the body member, and the drive member is threadedly engaged with the piston rod and movable relative to the body member. A mechanism is provided defining unit steps of movement of the drive member and corresponding unit steps of movement of the piston rod. The piston rod is arranged in contact with the bung or at a distance from the bung that is less than a distance of one corresponding unit step of movement. When the piston rod, the bung and the drive member are assembled in the body member, the piston rod is advanced with respect to the body member towards the bung, until the piston rod is stopped by the bung. The drive member is rotated until the piston rod begins to advance again and the drive member is then stopped, and the piston rod is fixed at or near the position obtained.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 5, 2019
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: David Aubrey Plumptre, Paul Richard Draper, David Richard Mercer, Naceur Rekaya, Paul Griffin, Robert Veasey
  • Patent number: 10166341
    Abstract: The invention relates to a medicament delivery device (100) having a a drive mechanism arranged to drive a plunger rod (12). A release button (4) is movable between an active and an inactive state, wherein the release button (4) in the active state allows the actuator (3) to move axially towards a proximal end position and wherein the release button (4) in the inactive state allows the actuator (3) can move axially towards the proximal end position or towards the distal end position.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: January 1, 2019
    Assignee: Carebay Europe Ltd
    Inventor: Anders Holmqvist
  • Patent number: 10149945
    Abstract: An injection device provides a casing which accommodates or forms a reservoir for a liquid drug; a plunger rod which can move relative to the casing in an axially forward direction to deliver the drug; and a dosing means which can move in the forward direction relative to the casing to prime the reservoir and which can rotate relative to the casing for selecting a dose to be injected. Rotation of the dosing means relative to the casing is prevented until a priming operation for priming the reservoir is completed. The dosing means comprises a dosing control means which is configured to enable rotation of the dosing means at the end of the priming stroke for selecting the dose and to prevent a rotation of the dosing means back into the position which the dosing means had at the end of the priming stroke relative to the casing.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: December 11, 2018
    Assignee: TECPHARMA LICENSING AG
    Inventors: Ulrich Moser, Jürg Hirschel, Markus Tschirren, Philipp Wälchli, Peter Stettler, Patrick Sackermann, Christian Schrul, Martin Berger, Nicolas Binggeli
  • Patent number: 10149946
    Abstract: An assembly for use in a drug delivery device includes a cartridge, a housing and a cartridge holder. The cartridge holder is releasably attached to the housing. The assembly includes a piston rod configured to move from a start position to an end position to dispense a dose of medication when the cartridge holder is attached to the housing, and the piston rod is configured to be reset to the start position when the cartridge holder is detached from the housing. The assembly further comprises a flexible element configured to axially fix the cartridge in the cartridge holder when the cartridge holder is attached to the housing. Furthermore, the assembly comprises a guiding element in threaded engagement with the piston rod. The flexible element is configured to fix the guiding element with respect to a housing of the drug delivery device when the cartridge holder is attached to the housing.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: December 11, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventor: Andreas Bernert
  • Patent number: 10143805
    Abstract: The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a dose setting member (120; 220) rotatably arranged at a proximal end of the housing (20) for setting of a dose, a base member (60; 260) having a proximally extending shaft portion (61; 261) at least partially enclosed by the dose setting member (120; 220), a last dose limiting member (140; 240) radially disposed between the dose setting member (120; 220) and the base member (60; 260) and having at least one radial stop (143; 243a, 243b) to limit a rotational displacement of the dose setting member (120; 220) relative to the base member (60; 260), wherein the last dose limiting member (140; 240) is rotatably locked but axially displaceable to one of the base member (60
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: December 4, 2018
    Assignee: Sanofi
    Inventors: Björn Wilden, Stefan Bayer, Philipp Zeitz, Wolfgang Pelzer
  • Patent number: 10130772
    Abstract: A handheld injection device includes a housing, a rotatable dose setting member and a power reservoir coupled to the dose setting member. Energy is stored in the power reservoir during rotation of the dose setting member. The injection device also includes a release member for receiving a force from a user and a rotatably arranged drive member engaging with a drive track of a piston rod. The device further includes a release clutch rotationally constrained to the housing and releasably engaging the drive member. The release clutch is positionable in a first axial position when the release member is in a dose setting position and in a second axial position when the release member is in a dose injection position. The axial position of the drive member within the housing remains constant when the release member is in its dose setting position and in its dose injection position.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 20, 2018
    Assignee: Sanofi
    Inventors: Joseph Butler, Matthew Jones, David Aubrey Plumptre, William Marsh, Robert Veasey
  • Patent number: 10124115
    Abstract: A push button safety injector includes a housing having a proximal end, a distal end spaced from the proximal end, and a longitudinal axis. An injection ram is positioned along the longitudinal axis and configured to actuate a fluid chamber. The injection ram is biased toward the distal end in an initial position. A sliding member is configured to retain the injection ram in the initial position. A safety member confines radial movement of the sliding member in the initial position and allows radial movement of the sliding member in an armed position. A button is moveable between an initial extended position and a depressed position. The button is engagable with the sliding member and configured to move the sliding member radially in the armed position. The sliding member releases the injection ram when the button is in the depressed position.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: November 13, 2018
    Assignee: ANTARES PHARMA, INC.
    Inventors: Kevin David Swanson, Julius Sund, Peter A. Hoeft, Patrick E. Madsen
  • Patent number: 10117996
    Abstract: A system comprising a state changing appliance and a drug delivery device, the state changing appliance comprising first interface means for rotationally locking to a first exterior portion of the drug delivery device, second interface means for rotationally locking to a second exterior portion of the drug delivery device, the first exterior portion and the second exterior portion being angularly displaceable relative to one another from a first relative position to a second relative position, which second relative position defines a set dose to be expelled by the drug delivery device, and limiter means for limiting a relative angular displacement between the first interface means and the second interface means.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: November 6, 2018
    Assignee: Novo Nordisk A/S
    Inventor: Mads Schenstroem Stefansen
  • Patent number: 10112016
    Abstract: A drive mechanism of a drug delivery device and a respective drug delivery device for setting and dispensing of a dose of a medicament are presented, where the drive mechanism has an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge containing the medicament, a dosing arrangement manually and axially displaceable relative to the housing for setting and dispensing of the dose, and an accessory drive operably engaged with the piston rod to support a manually operated dose dispensing displacement of the dosing arrangement.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: October 30, 2018
    Assignee: Sanofi-Aventis Deutschland GMBH
    Inventors: Paul Richard Draper, Anthony Paul Morris, Stephen Francis Gilmore
  • Patent number: 10022501
    Abstract: A medicament delivery device includes a housing, a container holder in the housing, an axially movable plunger, and an energy accumulating member adapted for displacing the plunger. The container holder is configured to accommodate a medicament container that includes a first piston arranged inside an opposite end portion of the container and a second piston arranged inside an intermediate portion of the container. The plunger includes an outer plunger rod, an inner plunger rod at least partially inside the outer plunger rod, a biassing arrangement for actuating the inner plunger rod, and a locking arrangement that, in a first state, locks the biassing arrangement in an energy-storing position and, in a second state, releases the biassing arrangement from the energy-storing position to displace the inner plunger rod into the container holder.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: July 17, 2018
    Assignee: Carebay Europe, Ltd.
    Inventor: Stephan Olson
  • Patent number: 10010678
    Abstract: An assembly for the administration of a selected dosage of insulin or other medicaments from a cartridge by moving a plug guided in said cartridge, comprises an adapter assembly for adapting cartridges with different dimensions or contents. The adapter assembly comprises a first threaded element threaded with a thread lead and movable in a moving direction to move the plug, and a second threaded element threaded with a thread lead for setting a selected dosage, pivotably screwed to said first threaded element and limiting the movement of said first threaded element, and wherein said thread lead of said first element and said thread lead of said second threaded element are adapted to the dimensions and/or the contents of said cartridge.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: July 3, 2018
    Assignee: EMPERRA GMBH E-HEALTH TECHNOLOGIES
    Inventors: Janko Schildt, Florian Rühle
  • Patent number: 9861751
    Abstract: A medication administering device, to which a preparation syringe containing a preparation is mounted, and which administers a preparation to a living body, and comprises a main body; a cylindrical syringe holder that is provided to the main body and into which the preparation syringe is inserted from the rear end side; a cylindrical syringe cover that supports the preparation syringe on the inner peripheral face side, and into which the preparation syringe is inserted from the distal end side; an inner case that guides the syringe cover and is removably fitted together with the syringe cover; and a distal end cap that guides the main body and is removably fitted together with the main body, and moves in conjunction with the syringe cover during attachment to the main body.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: January 9, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Toshiaki Iio, Hidenori Watanabe, Seiji Kikuchi, Yukihiro Takabatake
  • Patent number: 9861749
    Abstract: The present disclosure relates to a drug delivery device, in particular pen-type injectors, wherein a number or pre-set doses can be administered. In particular, the present disclosure relates to such drug delivery devices, where a user may activate the dose injection process and wherein the user is still able to control the dose injection process even after a dose injection process has been activated. The process of injecting a dose is supported by some kind of energy storing means as well as by a force to be exerted by a user. Moreover, the disclosure characterizes by a reduced amount of mechanical components.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: January 9, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventor: Philippe Nzike
  • Patent number: 9855388
    Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: January 2, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Malcolm Boyd, Richard Letham, David Plumptre, Robert Veasey, James May, Matthew Jones, Samuel Ghazaros
  • Patent number: 9789258
    Abstract: The present invention is directed at a dose setting mechanism for a drug delivery device, comprising an outer sleeve and an inner sleeve located at least partially within the outer sleeve wherein the outer sleeve is connected to the inner sleeve. To reduce noise excitations of the dose setting mechanism, at least one intermediate element is at least partially located in a clearance between the inner sleeve and the outer sleeve in such way that it reduces the relative movement of the inner sleeve and the outer sleeve along a play between the inner sleeve and the outer sleeve. The invention is further directed to a pen-type injector equipped with a respective dose setting mechanism.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 17, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Marc Holtwick, Michael Jugl, Axel Teucher
  • Patent number: 9775953
    Abstract: A mechanism for preventing setting of a dose, which exceeds the amount of a medicament in a reservoir in an injection device. The device can contain a threaded piston rod, a limiter and a driver. The three elements can be arranged such that during dose setting, the limiter is moved towards an end-of-content position, wherein dose setting is limited. The invention contains an accumulative and a non-accumulative embodiment. The invention further relates to a mechanism for preventing ejection of a dose exceeding the set dose.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 3, 2017
    Assignee: Novo Nordisk A/S
    Inventors: Christian Peter Enggaard, Claus Schmidt Moller, Tom Hede Markussen
  • Patent number: 9775952
    Abstract: A drug delivery device comprises a first component and a second component, wherein a substance is provided on at least one of the first component and the second component. An inner friction of the substance is great enough to stabilize at least one of the orientation and the position of the first component and the second component with respect to one another. The inner friction of the substance is small enough to allow relative movement of the first component and the second component necessary for the intended operation of the device. Furthermore, a method for assembling a drug delivery device is provided.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: October 3, 2017
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Michael Noderer, Timothy Giles Claughton, Warren Terry, Robert Veasey
  • Patent number: 9744313
    Abstract: A nebulizer and a housing part comprising a blocking device as well as use of a blocking device are proposed. The blocking device blocks a rotatable element of a counter device in a defined rotational position until the nebulizer is closed.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: August 29, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jens Besseler, Frank Herrmann, Holger Holakovsky, Herbert Argauer, Josef Gatz, Andreas Gorshoefer
  • Patent number: 9717856
    Abstract: An injection apparatus includes a counter wheel that is incremented by the dose delivery mechanism each time the device is fired. The apparatus includes a final dose disabling mechanism that prevents further usage once the final dose has been delivered. An anti-tamper feature is provided to prevent inadvertent or premature initialisation of the apparatus.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: August 1, 2017
    Assignee: OWEN MUMFORD LIMITED
    Inventors: Clive Nicholls, Robert Michael Wozencroft, Jeremy Marshall
  • Patent number: 9717859
    Abstract: A medication delivery device and/or dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having a dose setting system and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge.
    Type: Grant
    Filed: July 23, 2016
    Date of Patent: August 1, 2017
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Harms, Steffen Raab, Dominic George Webber, James Robert Howarth, Trevor John Beckett, Geoffrey Philip Gray, John David Cross
  • Patent number: 9713677
    Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: July 25, 2017
    Assignee: SHL Group AB
    Inventor: Mattias Daniel
  • Patent number: RE46814
    Abstract: A medication delivery device is provided which is switchable between an operational state and a resetting state and which comprises a housing having a proximal end and a distal end, a piston rod being moveable in a distal direction with respect to the housing for medication delivery, a conversion element adapted to at least partially convert a rotational movement of the piston rod into an axial movement of the piston rod, coupling means prevented from rotational movement with respect to the housing and adapted to engage with the conversion element in the operational state, a drive assembly comprising at least two drive assembly members and adapted for moving the piston rod in the distal direction, and a resilient member adapted to provide a force on the drive assembly for engagement of the drive assembly members. In the operational state of the device the coupling means is engaged with the conversion element, the conversion element thereby being prevented from rotation with respect to the housing.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: May 1, 2018
    Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Christopher James Smith, Michael Heald, Stephen David Butler, Mark Philip Horlock