Abstract: The present invention relates to a dose setting and expelling device comprising a drive member and a dose setting mechanism which simultaneously sets a given dose and stores the energy necessary for a subsequently driving the drive member in order to expel a dose of medicine from an injection device. According to the invention the dose setting mechanism allows adjustment in both directions, such that a given set dose can be reduced or cancelled by reversing the input motion, typically by rotating a setting member backwardly, this in contrast to the known devices which either requires an additional release mechanism or which cannot be reversed at all.

Abstract: The drive mechanism comprises a lead screw (5) and a lead screw nut, which are aligned with an axis (4). The lead screw has screw threads (6, 16) having the same pitch and being intertwined.

Abstract: A drive sleeve is arranged within a body and coupled with a dose member by means of threads. Stop means inhibit a shift of the drive sleeve while allowing a rotation of the drive sleeve. A clutch is provided to lock the dose member rotationally to the body in a releasable manner when a force is exerted on the dose member in the distal direction, the clutch permitting a movement of the dose member in the distal direction with respect to the body.

Abstract: An assembly for a drug delivery device is provided for. The assembly may comprise a housing body having a longitudinal axis. It may have a drive assembly having a drive member, the drive member being configured to be axially displaced with respect to the housing body during operation of the drive assembly for setting and/or dispensing a dose of the drug. The assembly may have a display assembly having a display and an indicator element, the indicator element being axially displaceable with respect to the housing body along the longitudinal axis or the indicator element being rotationally displaceable with respect to the housing body around a rotational axis which is inclined, in particular perpendicular, to the longitudinal axis. The display may be configured such that it displays a first state when the indicator element is in a first position and switches to a second state when the indicator element is displaced away from the first position.

Abstract: A first input member and a second input member are arranged along a first axis and coupled in such a manner that a movement of the first input member along the first axis is converted into a rotational movement of the second input member with respect to the body . A first output member and a second output member are arranged along a second axis and coupled in such a manner that a rotational movement of the first output member is converted into a movement of the second output member along the second axis with respect to the body. The second input member and the first output member are releasably rotationally coupled.

Abstract: A method and system for proving a drug delivery device having a variable dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first and second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.

Abstract: A medicament delivery device for a reconstituted medicament, comprising a proximal housing part (12; 12?; 12??), a distal housing part (10; 10?; 10??), a medicament delivery drive unit and actuation means, wherein the medicament delivery drive unit is mounted in said distal housing part and wherein the actuation means further include an activation member (74; 101; 201) which is displaceable between an inactive position wherein the actuator is prevented from engaging the medicament delivery drive unit and an active position wherein the actuator is able to engage the medicament delivery drive, whereby the actuator is capable of interacting with said medicament delivery drive unit to perform a delivery of the reconstituted medicament only in the active position of the activation member and in the second position of the medicament delivery drive unit.

Abstract: A system for treating meibomian gland dysfunction. A controller controls a lid warmer attached onto a patient's eye to generate heat on the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. An eyecup may be employed to generate a force on the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss.

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes an annular groove formed in a distal end and adapted to receive a circlip disposed in a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: The present invention relates to a medicament delivery device comprising a housing (10,12), capable of containing a medicament container (14), a plunger rod (18) and a drive member (34) arranged to said plunger rod and capable of acting on said plunger rod (18) for moving it in the proximal direction of the device for expelling a dose of medicament from said medicament container (14), a dose and drive setting mechanism (52) comprising a dose setting member (56) operably connected to a force member (82) such that setting of a dose causes said force member (82) to be energized. The intermediate member (68) is configured to interact with a dose setting sleeve (50) through a first unidirectional connection (64, 62), configured to interact with said drive member (34) through a second unidirectional connection (70, 72), and configured to interact with a dose drive sleeve (76) through a third connection (74,78).

Abstract: A needle assembly for a drug delivery device includes a cup-shaped receptacle of non-circular cross-section having a bottom section supporting a needle element. The needle element is adapted to penetrate a pierceable seal of a cartridge to be disposed in a cartridge holder of the drug delivery device. The receptacle includes a fastening mechanism adapted to engage with a fastening mechanism of a support section of the cartridge holder for releasably fastening the needle assembly. The fastening mechanisms are convertible into a release configuration by changing the distance between mutually corresponding fastening mechanisms through twisting the receptacle with respect to the support section.

Abstract: A method and system for priming a drug delivery device. The drug delivery device includes a forced priming feature that requires the user to move the dose dial sleeve axially to cause the spindle to pre-load a cartridge bung before a first dose can be dialed.

Abstract: An injection device includes a syringe with a hollow needle and a stopper for sealing the syringe and displacing a medicament stored in the syringe. An arrangement for transferring a translation of a drive means to a plunger for pushing against the stopper includes a release latch pivoted at one end and connected to either the drive means or the plunger. The other end of the release latch engages the other one of the drive means or the plunger. The non-pivoted end of the release latch disengages by rotation upon contact between a ramp and another component when the stopper has displaced most of a predefined medicament dose. The release latch is long enough to provide a clearance between the plunger and the drive means when engaged to allow the plunger, stopper and needle to be retracted inside the syringe or a housing after disengaging the release latch.

Abstract: An injection device including a pusher, a dosing element and a coupling element, the pusher being displaceable in an injection direction and having at least one holding or detent area, e.g. a toothed area, for detachably holding the pusher relative to the injection device, wherein the coupling element positions the pusher relative to the dosing element for fixing the axial position of the pusher relative to the dosing element.

Abstract: A method and system for limiting a maximum dose that may be set in a drug delivery device. A dose setting mechanism, which is operable to be coupled to a medication cartridge, comprises a lock-out mechanism that prevents one from setting a dose greater than the medication in the cartridge. The lock-out mechanism comprises a rotatable shaft. A helical groove having a first pitch is provided along a first portion of the rotatable shaft and a second pitch provided along a second portion of the rotatable shaft. The first pitch is different from the second pitch. A third pitch may be provided on a third portion of the shaft. This third pitch is provided at the end of the second pitch and is preferably different than the second pitch. The lock-out mechanism further comprises a non-rotating member disposed on the helical groove of said shaft.

Abstract: Disclosed herein are cartridge assemblies that include coding features that help dedicate a medicament reservoir to specific injection devices. An exemplary cartridge assembly comprises a cylindrical inner surface for holding medicament and a cylindrical outer surface comprising at its proximal end one or more stops configured as coding elements protruding from the cylindrical outer surface. Each coding element is configured only to engage a corresponding coding feature on a dose setting and delivery mechanism, thereby allowing only the correct cartridge assembly to connect to the dose setting and delivery mechanism.

Abstract: An injection device for administering a dose of a liquid medicament is disclosed. The device includes a syringe containing the dose and a hollow injection needle. The device includes a stopper translatably disposed within the syringe and a plunger connectable to the stopper and translatable in at least a proximal direction to displace the stopper. The device further includes a releasable noise component capable of, upon release, generating an audible and/or tactile feedback. Proximal displacement of the stopper causes the dose to be expelled through the injection needle. The noise component is released when the plunger reaches a position relative to the syringe in which the stopper is located in proximity of a proximal end of the syringe. The released noise component impacts on at least one component of the injection device to generate the audible and/or tactile feedback indicating the end of the injection.

Abstract: A pen body assembly (100) for a drug delivery pen includes a pen body (101) and a dose setting body (111) movably connected to the pen body (101). A knob (109) is connected to the dose setting body (111) for moving the dose setting body (111) relative to the pen body (111). One of the pen body (101) and the dose setting body (111) has a thread groove (107) having a varied pitch disposed thereon and the other one has a protrusion (105) engaging the thread groove (107).

Abstract: A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.

Abstract: A dose setting mechanism for an injection device having a rotatably operated dose setting member, a presetting member being operable to limit the maximum dose settable by the dose setting member, and a first stopping member is operatively connected to the presetting member where the position of the first stopping member indicates the preset maximum dose. The first stopping member is adapted to rotatably engage with a second stopping member when the preset maximum dose has been set, thereby preventing setting of a further dose. The first and/or the second stopping member is/are movable along with the dose setting member, the first and second stopping members thereby being moved into engagement when a dose is set. Thereby a dose can be preset and the preset dose can easily be repeatedly set while ensuring an accurate dosage. Helps persons being visually impaired or having poor dexterity in setting a correct and accurate dose.

Abstract: A medical delivery system having a container and a dosing assembly, and wherein one of the container and the dosing assembly comprises a rotatable element adapted to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system. A dosing assembly suitable for use in said medical delivery system.

Abstract: An air shot or priming mechanism for an injection pen. The injection pen comprises a cartridge-holder and a housing. The cartridge-holder interacts with a nut-member capable of driving the piston rod forward when relatively rotated. The cartridge-holder is rotational coupled to the housing such that rotation of the cartridge-holder relatively to the housing causes the nut-member and the piston rod to rotate relatively, thus the relative angular rotation between the cartridge-holder and the housing determines the size of the air shot so performed.

Abstract: Medicament delivery device comprising relatively movable housing parts, a medicament container, a proximal plunger rod part and distal plunger rod part in threaded engagement with each other, wherein said proximal plunger rod part is movably arranged in relation to said housing part sand in contact with a stopper of said medicament container, a lever pivotally attached to said housing parts and to the distal plunger rod part. The housing parts are ergonomically shaped having a grip-size for achieving a full hand grip and wherein said distal housing part and said proximal housing part are operably interconnected to each other through said lever such that a relative movement of said housing parts is capable of operating the lever for setting and injecting a dose.

Abstract: An injection device for injection of set doses of medicine from a cartridge, in which syringe a dose is set by screwing a nut up along a threaded piston rod, whereby a dose setting drum, which carries on its cylindrical surface along a helix a scale of which a number corresponding to the set dose is shown in a window in the housing of the syringe, and an injection button, which is elevated over the end of the syringe, are moved axially a distance which is larger than the axial movement of the nut. A gear wheel gear transmission is established between the nut and the injection button.

Abstract: A drug delivery device comprises a housing and a piston rod arranged in the housing. The piston rod is adapted to be moved along an axial direction to dispense a fluid. A drive member arranged in the housing is operatively coupled to the piston rod and adapted to set up a dose of fluid for dispense in response to a first movement. The drive member is also adapted to move the piston rod to dispense the dose in response to a second movement. The drug delivery device also comprises a pre-dispensing drive member operatively coupled to the drive member and the housing and adapted to move at least the drive member by a pre-dispensing distance between its first and second movement.

Abstract: An assembly for a drug delivery device is provided, the assembly comprising a blocking element and a piston rod having an interaction feature which is adapted and arranged to mechanically cooperate with the blocking element. For delivering a dose of a drug, the piston rod is configured to be moved from an initial position to an end position with respect to the blocking element, wherein the interaction feature is provided along the path between the initial position and the end position. An operating noise is provided to the user when the interaction feature mechanically cooperates with the blocking element while moving the piston rod from the initial position to the end position for dose delivery. The interaction feature is adapted for homogenizing the operating noise so as to prevent the operating noise from being interpreted by the user as signalling the end of the dose delivery operation. Furthermore, a drug delivery device is provided.

Abstract: The invention relates to a dosage system for setting a dosage volume of a flowable medium. The dosage system comprises a longitudinal axis, a dosage container for receiving the medium, and a dosage piston body which is adapted for sealed displacement in the dosage container between an initial position and a dosage position. In the initial position, the dosage piston body is fully inserted in the dosage container while in the dosage position, the dosage piston body has been pulled out of the dosage container along a path corresponding to the desired dosage amount of the medium. The dosage system further exhibits a draw-up limiting member for limiting a draw-up path of the dosage piston body in the dosage position, the draw-up limiting member being axially securable to the dosage container in one of several limiting positions relative to the longitudinal axis.

Abstract: A drug delivery device for dispensing of a dose of a medicinal product, comprising a holder (14) for a product-containing cartridge (16), the cartridge (16) having a piston (18) slidably arranged therein in an axial direction, a piston rod (12) to be operably engaged with the cartridge's piston (18) for dispensing of a dose of the medicinal product, and at least one spacer (20) being selected according to a relative distance between piston (18) and piston rod (12) and being disposed between the piston rod (12) and the piston (18) for eliminating axial clearance between piston (18) and piston rod (12).

Abstract: An injection device for dispensing a product, the injection device including a moveable element which is moved for a dispensing operation, a spring, a product container holder and a product container, wherein the spring pushes against the moveable element to move the moveable element to an initial position after the dispensing operation has ended and against the product container to seat the product container in the product container holder.

Abstract: A resettable drug delivery device includes a body, a cartridge holder for receiving a cartridge, and a releasable coupling connecting the cartridge holder to the body or the dose setting mechanism. During an initial rotational coupling movement of the cartridge holder relative to the body or the dose setting mechanism the cartridge holder is caused to move in a first axial direction relative to the body or the dose setting mechanism and during a continued rotational coupling movement of the cartridge holder relative to the body or the dose setting mechanism the cartridge holder is caused to move in a second, contrary axial direction.

Abstract: The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir 102 with a repair catheter 104 operably attached; a flow control device 106 disposed between the sealant reservoir 102 and the repair catheter 104, and the flow control device 106 responsive to a flow control signal 108; a heart phase detector 114 generating a diastole phase signal 112; an injection switch 122 generating a injection signal 120; and a flow controller 110 responsive to the diastole phase signal 112 and the injection signal 120, and generating the flow control signal 108. A method of sealing a perivascular leak comprises identifying the perivascular leak 140; inserting a repair catheter to the perivascular leak 142; injecting sealant at the perivascular leak 144; and removing the repair catheter 146. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.

Abstract: An improved drug delivery device is provided having a piston rod that incorporates on its proximal end at least one guidepost that is configured for transmitting axial and rotational forces from a drive mechanism. The device comprises a drug delivery device housing and a medicament contained in the drug delivery device housing.

Abstract: A coded cartridge holder system is disclosed for use with a cartridge assembly (20) containing a fluid and a delivery device (10), where the system has keyed connectors (5, 5?, 6, 6?) to prevent accidental attachment of the wrong fluid delivery device (10). The system comprises a coupling (1) attachable to the dose setting portion (12) of the device (10) and keyed to the proximal end of the cartridge holder (14). The cartridge holder (14) may also contain medical coding (27, 28) to correspond to matching coding (27?, 28?) on the distal end of a cartridge assembly (20).

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: A two-dose autoinjector for a medicament wherein the locking and releasing of the drive spring of the autoinjector is controlled through stepped guides with ramps for two successive slidings of slides operated by the spring and connected with the syringe and plunger. The guides and the slides are pivotable relative to one another and the sliding direction, while the syringe can only slide axially. To enable or disable the sliding of the slides within the guides an angularly angularly mobile arming member is provided formed with a guide track substantially equal to that of the stationary member where the guides are formed.

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.

Abstract: The present invention relates to a container comprising: a body; a pusher movable with respect to the body between an initial position and an end-of-use position; a locker located on the pusher and forming an abutment so as to be able to abut against the body between the initial position and the end-of-use position, wherein, the abutment abuts against the body to limit distal movement of the pusher relative to the body to a pusher locking position located between the initial position and the end-of-use position; a locking arrangement capable of, temporarily, locking the locker on the pusher so as to define a locker locking position of the locker on the pusher, the locker locking position establishing the position of the abutment relative to the pusher so as to set the pusher locking position; and, an unlocking arrangement designed so that, with triggering, the locking arrangement is released so as to allow the locker to be displaced relative to the pusher and for the pusher to be moved past the pusher locking

Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicinal product, comprising: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, an adjusting assembly adapted to eliminate axial clearance between the piston and the piston rod, wherein the adjusting assembly comprises at least one radially extending spike element for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

Abstract: The present invention relates to a drug delivery device for dispensing of a predefined dose of a medicinal product, comprising: a housing, a cartridge holder adapted to receive a cartridge containing the medicinal product to be dispensed, the cartridge holder being connectable to the housing, a drive mechanism to be operably engaged with the cartridge for setting and/or dispensing of a predefined dose of the medicinal product, wherein the drive mechanism is axially slidingly supported in the housing for compensating axial clearance between the drive mechanism and the cartridge and wherein the drive mechanism is axially fixable relative to the housing.

Abstract: The present disclosure concerns an indication mechanism for an automatic applicator, particularly for insulin or other liquid preparations, particularly for multiple injection administration of set doses of a medicine from an exchangeable container, for example for the self-application of insulin by diabetes patients. An indication mechanism for an automatic applicator, having an assembly of at least two barrels movably coupled to each other has an indication barrel mounted on the driving barrel contains only marking on its external surface and is co-axially connected to the pull-push control nut.

Abstract: A pen-type injector is improved so that a user may select a delivery dose of a medicinal product from a multidose cartridge. The injector includes a housing, the cartridge containing the medicinal product retained within the housing, a piston rod, a dose selecting member to select the dose of the medicinal product to be expelled, and a drive member to expel the selected dose of the medicinal product. The housing is formed unitary so that the dose selecting member and the drive member are moveably retained within the housing. The injector may include a ratchet associated with an insert to ensure the piston rod only rotates in a single direction through the insert, a button located on the drive sleeve, and a clutch which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: The invention concerns a dosing system for adjusting a dose volume of a fluid medium. The dosing system has a longitudinal center axis (1), a dosing sleeve (3) with at least one communication opening (7), a dosing plunger (4), which can move axially in the dosing sleeve (3) between a retracted and a depressed position to take up and dispense the medium through the communication opening (7), and a retraction limiting element (5) to delimit a maximum axial retraction path of the dosing plunger (4). The retraction limiting element (5) in at least one position can be axially fixed to the dosing plunger (4) and can move radially to the longitudinal center axis (1) between an inner position, axially fixed on the dosing plunger (4), and an outer position relative to the dosing plunger (4). In the inner position, it is completely inside the dosing sleeve (3).

Abstract: Described are hemostasis devices useful for implantation in biopsy tracts, which device comprise highly compact, dried hemostatic sponge elements. Preferred devices also include compacted sponge matrices exhibiting high density and rigidity in combination with high volumetric expandability when wetted. Also described are methods for making and using such devices.

Abstract: The present invention relates to a medicament delivery device comprising a housing (12); a medicament container (14) arranged within said housing; medicament delivery drive means (22, 24); manually operable release means (38); and a movement speed control mechanism (44, 46, 48) comprising at least one fixed, flexible and elongated compartment (48) containing a liquid, and at least one flexible speed control member (44, 46) connected to the medicament delivery drive means; wherein said at least speed control member is arranged to be pressing on said at least one compartment for forcing said liquid past said member and thereby creating a movement speed control of said medicament delivery drive means when moved.

Abstract: The invention relates to a dose setting mechanism (1) for a drug delivery device (2), comprising a number of separate dose setting elements (3.1 to 3.n), wherein a dose volume and/or a dose number are/is set by moving at least one of the respective dose setting elements (3.1 to 3.n) from a stack position (I) to an initial position (II), and wherein a medicament dose volume is applied by moving at least one dose setting element (3.1 to 3.n) from the initial position (II) to a dispense position (III) and wherein the movement of the dose setting element (3.1 to 3.n) from the initial position (II) to the dispense position (III) is limited by at least a height (h) of the dose setting elements (3.1 to 3.n) in the initial position (II), wherein each dose setting element (3.1 to 3.n) comprises a plurality of bulges (B1 to Bm) on at least one surface side (S1), wherein the height (h) of each dose setting element (3.1 to 3.n) equals a sum of the thickness (D) of the dose setting element (3.1 to 3.

Abstract: A nasal cavity administration container includes a body section including a medical fluid storage section having an opening and a plunger having a pressing part, and a plunger moving amount regulation member having a stopper and being engaged with the body section, an engagement with the body section being relieved only in a state where the pressing part abuts on the stopper. When the plunger is pushed into the medical fluid storage section, the plunger moves forward until the pressing part abuts on the stopper. The plunger is further pushed into the medical fluid storage section with the plunger moving amount regulation member detached from the body section. The nasal cavity administration container can administer a medical fluid easily and appropriately.

Abstract: A device 560, for administering multiple single doses of a medicated cream, includes a cartridge 562 having a barrel 564 for containing the cream, a plunger 608 for moving the cream from within the cartridge, and a stem 610 for moving the plunger within the cartridge. A carrier 612 is formed with a cartridge-receiving nest 712 for receiving the barrel 564. A plurality of spaced, transaxial grooves 726, 728, 730 and 732 are formed in the carrier 612 for receiving a flange 572 of the cartridge 562 during the dispensing of multiple, successive, single doses of the cream. The carrier 612 is formed with a pair of resilient ears 750 and 752 and a passage 738 for removably retaining the stem 610 with the carrier while allowing axial movement of the stem.

Abstract: A drive mechanism for a medication delivery device containing a resilient member and having a rotation member configured to be rotated in a first direction during setting of a dose of a medication and to be rotated in a second direction during delivery of the dose, where rotation member is coupled to a drive member that is coupled to a piston rod such that on dose delivery the piston rod is displaced in a distal direction to dispense a medicament and where the resilient member prevents movement of the drive member and the piston rod during dose setting.