Abstract: A sprayer is capable of inhibiting or preventing clogging occurring in a nozzle upon ejection of a liquid through the nozzle. A sprayer includes liquid supply for separately supplying a first liquid and a second liquid different in liquid composition, and a nozzle. The nozzle includes a first flow path and a second flow path along which passes the first liquid and the second liquid supplied from the liquid supply. In addition, the nozzle includes a third flow path along which passes a gas. A merge part is provided at which the first flow path and the second flow path merge at their respective halfway parts. A vent is provided at the merge part for allowing the gas which has passed through the third flow path to flow into the merge part.

Abstract: An enteral feeding assembly is described which includes a base and a catheter positioned through the base. A portion of the catheter extends distally away from the base, and has a retainer provided on a distal end of the catheter. The retainer includes a plurality of struts having a flexible, preformed configuration which cooperate to form at least a portion of a spherical shape with openings between the struts. A shroud is positioned over at least a proximal portion of the struts to prevent the struts from causing irritation or embedding in a body lumen. The retainer is movable between an insertion configuration and a deployed configuration. An obturator and actuator are used to move the retainer between positions. A method for inserting and removing an enteral feeding assembly is also provided.

Abstract: The devices and methods shown provide for the minimization of extravasation during arthroscopic surgery. The extravasation minimization device allows a surgeon to drain excess fluids from the soft tissue surrounding the surgical field while also providing a stable surgical portal for arthroscopic surgical instruments.

Abstract: A surgical retention port particularly useful as an arthroscopic port for shoulder surgery is provided. The surgical retention port has an inner cannula defining a throughbore, a plurality of rotatable fingers coupled to the inner cannula, and an outer cannula extending around the inner cannula. Rotation of the inner cannula relative to the outer cannula causes the rotation of the fingers from a first position where the fingers assume a collapsed configuration to a second position where the fingers assume an extended or open configuration.

Abstract: A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the treatment site; and introducing a treatment agent through the needle to the treatment site. A composition including an inflammation-inducing agent and a carrier in the form of microspheres having a particle size suitable for transvascular delivery. A composition including a therapeutic angiogenesis promoter in a carrier and an opsonin-inhibitor coupled to the carrier. An apparatus for delivery of a therapeutic angiogenesis promoter.

Abstract: An irrigated catheter with uniform cooling and/or uniform fluid distribution in longitudinally spaced apart elution holes by varying the diameter of a fluid delivery lumen. A number of elution holes are provided in a tip region of a catheter body, and these elution holes are in fluid communication with the lumen through ducts. The fluid delivery lumen may be provided with a flow constrictor to restrict flow of fluid towards the distal region.

Abstract: A hemostasis instrument for actively stopping the bleeding, in particular after an open, laparoscopic, or endoscopic operation on a patient, having several hemostasis components. The hemostasis instrument has at least the following hemostasis components:—a thermal hemostasis device for tissue coagulation by producing a temperature above the coagulation temperature of biological tissue by means of a coagulation electrode;—a biochemical hemostasis device for producing a silent electric discharge by means of at least one discharge electrode, and an insulating device, wherein the insulating device is arranged between the discharge electrode and the tissue to be treated;—a supplying device for supplying substances that influence blood clotting to the tissue to be treated, and—a supply device for supplying noble gas to the tissue to be treated.

Abstract: The present application discloses embodiments related to an implant and a method of forming an implant configured to treat a fractured bone. The implant can include a body having a proximal end, a distal end, and an outer surface extending from the proximal end to the distal end, wherein the body defines a central axis extending from the proximal end to the distal end; and a high tensile strand positioned adjacent the body such that at least a portion of the strand extends at least partially along the outer surface of the body in a direction substantially parallel with the central axis, and wherein the strand is loaded with an active agent.

Abstract: A valve for controlling fluid flow through a flow passage. The valve includes a tubular valve body defining a longitudinal axis and having an interior surface and an exterior surface. The valve body defines first and second valve ends and a tip portion is supported on the valve body and located at the second valve end. A cap member is supported on the valve body and includes a closed end formed by an end wall having an aperture for receiving the tip portion. The aperture includes a lip portion surrounded a groove on an interior of the cap member to facilitate a pressure seal between the aperture and the tip portion.

Abstract: An anti-clogging catheter includes a tubular cannula defining a fluid passageway and shaped and tipped to removably insert within and be removed from a human body, where the cannula has a proximal end with a first interior surface defining a first interior diameter and a distal end with a second interior surface defining a second interior diameter that is smaller than the first interior diameter. A stylet is movable within the fluid passageway between the proximal end and the distal end and has an outer diameter substantially equal to the second interior diameter.

Abstract: An interventional medical device, for example, a chronic implantable medical electrical lead or drug delivery catheter, or an acute medical therapy delivery and/or diagnostic tool, such as a guide catheter, includes a label formed by laser marking a TiO2-loaded silicone medical adhesive, which is primarily employed for filling and bonding in the device. A laser marking apparatus is employed to form marks of the label in the cured adhesive that forms a backfill and bond in the device.

Abstract: A two-phase surgical procedure is disclosed for creating a pneumostoma to treat chronic obstructive pulmonary disease The first phase is a procedure to induce creation of a localized pleurodesis and is preferably performed as an outpatient procedure. The second phase is a procedure to introduce a surgical instrument into the lung via the pleurodesis to create the pneumostoma. An interval of about one of more days between the first and second phases allows the formation of a stable pleurodesis to prevent pneumothorax during the procedure.

Abstract: A flexible endoscope for extending between an incision and a surgical site, the flexible endoscope including an endoscopic cylinder received by an outer flexible sleeve, the endoscopic cylinder including an outer contact surface received by the flexible sleeve with a helical thread, a flanged structure associated with the flexible sleeve and corresponding to a proximate handle end of said endoscopic cylinder, and a directional guide angularly extending from said outer surface and tapered.

Abstract: Sealing device for sealing externally debouching, natural or artificial body canals of animals or human beings, the device enabling liquid tight sealing against the inner wall of the bowel system of the animal or human being, the device further being made from a resilient material. The device is soft and resilient and may thus not trigger the analreflex, but is still able to provide a fluid-tight seal.

Abstract: A medical catheter comprising a first return lumen, a plurality of withdrawal lumens, a first clamping member and a plurality of intake extension tubes. Each intake extension tube communicates with an intake lumen of the catheter to provide fluid communication with the respective intake lumens. The intake extension tubes are positioned in a stacked arrangement, and the clamping member has a plurality of posts to receive the stacked tubes to limit lateral movement thereof.

Abstract: A cannula provides access to a surgical site for a camera instrument and one or more minimally invasive surgical instruments. The cannula may include a curved or flexible section when used with flexible surgical instruments. A service port is defined in a sidewall between proximal and distal ends of the cannula, the service port being large enough to allow an object to be transferred between the instruments and a location outside the cannula. An end effector of the surgical instrument may be positioned within the cannula adjacent the service port. The camera instrument may be positioned to place the end effector within a field of view of the camera. An object may be transferred between a service instrument and the surgical instrument within the field of view of the camera.

Abstract: The assembly comprises two or more catheter tubes fused together to form a fused catheter bundle. Each tube has at least one lumen extending longitudinally through the catheter from its distal end to its proximal end and wherein at least one of said tubes comprises a pressure resistant lumen. The tubes are fused together by use of heat & pressure generated by heat shrinkable tube slides positioned over a segment of the catheter tubes while mandrels are positioned within each tube lumen. After cooling, the heat shrinkable tube may be removed and the mandrels removed such that and the fused catheter bundle is formed. One or more of the tubes may be of a different hardness, material and/or color. A distal end of the fused catheter bundle can be split free floating, stepped or tapered tipped. A non fused portion may form catheter extension legs.

Abstract: The catheter includes a hollow shaft, at least one adhering portion provided on an outer surface of the shaft, and plural protrusions arranged on the adhering portion. The protrusions are configured to increase a contact surface area to show adhesive strength due to a Van der Waals force.

Abstract: Embodiments of the disclosure include methods and systems for attaching an articulation section. In an embodiment, a medical instrument includes a first tubular member including a first end. The medical instrument also includes a second tubular member including a first end. The second tubular member includes a plurality of layers including an inner layer and a first layer including a fluorinated material. The inner layer includes a first section disposed under the first layer and a second section extending out from under the first layer. A portion of the first tubular member overlaps and is bonded to at least a portion of the second section of the inner layer of the second tubular member.

Abstract: The present invention relates to a polymer matrix, characterized in that it comprises a) an electron donating constituent and b) metal particles comprising at least one metal chosen from palladium, gold, ruthenium, rhodium, osmium, iridium, and platinum. The polymer matrix makes it possible to improve the biocompatibility and antimicrobial properties of substrates coated with said polymer matrix.

Abstract: A surgical access device is provided having a cannula and obturator. The cannula has a housing and tube section with an anchor located about the tube section. The obturator has a mechanism to deploy the anchor and adjust the cannula length. The anchor is moveable between a deployed and undeployed state where the undeployed state facilitates insertion and removal of the access device and the deployed state assists in fixation of the cannula in an anatomic structure. Anchor deployment is independent of cannula length adjustment.

Abstract: A surgical access device is provided having a cannula and obturator. The cannula has a housing and tube section with an anchor located about the tube section. The obturator has a mechanism to deploy the anchor and adjust the cannula length. The anchor is moveable between a deployed and undeployed state where the undeployed state facilitates insertion and removal of the access device and the deployed state assists in fixation of the cannula in an anatomic structure. Anchor deployment is independent of cannula length adjustment.

Abstract: There is provided a transendoscopic medical instrument which can insert, remove and latch a plurality of medical items including a flexible guide unit with respect to a transendoscopic sheath which is selectively inserted into a body cavity such as a bronchial branch.

Abstract: A needle-based medical device including a needle guide and a method for constructing the same are disclosed. The needle-based medical device includes a tube having a first lumen; a needle guide which is dimensioned to be inserted into the lumen of the tube, and a needle. The needle is inserted such that an end is positioned in the needle guide. A glue may also be provided to secure the needle guide to the tube. In one embodiment, the tube may be made of extruded plastic.

Abstract: A medical device, at least a portion of which is formed from a polymer composition including at least one liquid crystal block copolymer having at least one A block and at least one B block wherein the A block is formed of mesogenic repeat units and the B block is a soft block.

Abstract: Drainage catheters for use in a variety of medical procedures are presented herein. The drainage catheter features an improved tension member locking mechanism. In use, once the drainage catheter is placed as desired, a second connector piece is rotated relative to a first connector piece to wind the tension member around a spooling region and pull the distal end of the catheter tube into a locked configuration. Once the tension member is tensioned, the first and second connector pieces are pulled into a locking engagement thereby securing the catheter tube in the locked configuration.

Abstract: An apparatus is provided for decreasing or eliminating flow of fluid between a probe and an incision during surgical procedures. The apparatus may comprise a deformable layer on the probe. The deformable layer may be comprised of a polymer foam, which may be covered with a surface layer. In another embodiment, baffles on a base layer are provided. The deformable layer or baffles may be on a slidable base surrounding the probe.

Abstract: A tube comprising an inner layer, an outer layer and a barrier layer disposed between the inner layer and the outer layer, wherein the barrier layer is bound to the outer layer by a layer of adhesive disposed between the outer layer and the barrier layer and the barrier layer is bound to the inner layer by a layer of adhesive disposed between the inner layer and the barrier layer, wherein the inner layer comprises a polyethylene, the outer layer comprises a thermoplastic polyurethane and the barrier layer comprises a material that acts as a barrier to gas.

Abstract: Aspects of the claimed invention relate generally to devices for delivering bone graft compositions to implants that have been positioned between vertebral bodies during surgery and methods of using such devices. Embodiments of the invention provide ease of bone graft delivery in situ while providing an environment for the mixing of bone graft, insertion of the bone graft, and packing of the graft into the voids above and below the implant.

Abstract: An anti-biofilm catheter comprising a tubing configured to be disposed within a luminal system, wherein the tubing comes in contacting engagement with a blood flow within the luminal system in vivo. The catheter comprises a surface disposed over at least a portion of the tubing, wherein the surface comprises a surface profile having a skewness value of from about ?0.01 to about ?0.6 such that few or no components of the blood flow is capable of attaching themselves to the surface to encourage biofilm formation. The surface profile further comprises a kurtosis value of from about 2.7 to 3.3.

Abstract: Methods and devices for preventing fluid flow through the relatively short guidewire lumen of a rapid exchange catheter. The guidewire lumen for a rapid exchange catheter is provided with a narrowed or sealed section allowing for passage of a guidewire therethrough while preventing fluid flow while a guidewire is disposed therethrough. The narrowed or sealed section extends for a relatively short length of the guidewire lumen to avoid creating excessive friction between the guidewire and the guidewire lumen. In several embodiments the narrowed or sealed section is placed proximal of the distal end of the guidewire lumen.

Abstract: A trocar sleeve assembly including a cannula connected to a housing assembly to define a working channel, wherein the housing assembly includes a housing that defines an opening in fluid communication with the working channel, a sleeve slidably received over the housing to define an annular region between the sleeve and the housing, a first sealing member forming a first seal between the sleeve and the housing, and a second sealing member forming a second seal between the sleeve and the housing, the second sealing member being axially spaced from the first sealing member to define a chamber in the annular region, and an insufflation port in fluid communication with the chamber, wherein the sleeve is slidable relative to the housing between a first position, wherein the chamber is in fluid communication with the opening, and a second position, wherein the chamber is fluidly decoupled from the opening.

Abstract: A surgical access device is provided having a cannula and obturator. The cannula has a housing and tube section with an anchor located about the tube section. The obturator has a mechanism to deploy the anchor and adjust the cannula length. The anchor is moveable between a deployed and undeployed state where the undeployed state facilitates insertion and removal of the access device and the deployed state assists in fixation of the cannula in an anatomic structure. Anchor deployment is independent of cannula length adjustment.

Abstract: An applicator for use with an ultrasound transducer assembly is disclosed. In an embodiment, an applicator includes a nozzle body having an interior and an exterior surface; a nozzle liner having an interior and an exterior surface and being engageable with the nozzle body such that a plurality of channels are defined at least in part by the exterior surface of the nozzle liner and the interior surface of the nozzle body, each of the plurality of channels having an inlet and an outlet; a passageway defined by a space between the nozzle body and the nozzle liner, in fluid communication with the inlets of each of the plurality of channels; and an opening sized and shaped for introducing fluid to the passageway to provide fluid flow from the outlet of each of the plurality of channels essentially simultaneously. Kits and methods are also disclosed.

Abstract: An ophthalmic microsurgical system is described for treatment of eye diseases, such as glaucoma, using minimally invasive surgical techniques. The microsurgical system includes a thin walled outer sheath microcannula 1 slidably disposed about an inner member 4, which extends slightly beyond the distal end of the microcannula 1. The inner member 4 may be straight or curved and may optionally include a surgical instrument and/or a sensor or signaling beacon. The microsurgical system is used in a surgical procedure for opening Schlemm's Canal to provide drainage of aqueous fluid in order to relieve excess intraocular pressure that results from glaucoma and other diseases of the eye.

Abstract: The present invention refers to medical devices comprising a modified Co-Polymer or to the modified Co-Polymer itself having high flexibility and high stress resistance, especially tensile strength or tear resistance, in addition to the good physical characteristics of a Block-Co-Polymers of a polyamide and a polycarbonate diamine.

Abstract: A single-phase surgical procedure is disclosed for creating a pneumostoma to treat chronic obstructive pulmonary disease. In a single-phase technique the pleurodesis is formed at the same time as the pneumostoma and does not require a separate step. The thoracic cavity is accessed to visualize the lung, the pneumostomy catheter is inserted into the lung and then the lung is secured to the channel through the chest wall creating a sealed anastomosis which matures into a pleurodesis after the procedure.

Abstract: An infusion set component of a fluid infusion device and/or a fluid infusion port component for delivery of fluid to a patient is compatible with a cooperating fluid channel module. The fluid channel module includes a body section having coupling features to mate with a base of the component. The fluid channel module also includes an interior fluid flow channel formed within the body section to receive fluid from the fluid infusion device and/or from a syringe or pen delivery device. The fluid channel module also includes a conduit having a first end in fluid communication with the interior fluid flow channel, and having a second end to deliver the fluid to the patient.

Abstract: Provided are catheters useful for penetrating the vascular wall and delivering medicament as necessary to tissue proximate the vasculature. Such catheters are particularly useful in delivering site specific medicaments to the tissue which can be damaged by hemorrhagic stroke, ischemia, and the like. Methods of using such catheters are also disclosed.

Abstract: Disclosed are implantable medical devices for the occlusion of a bodily lumen, cavity, vessel, or organ, as well as methods for manufacturing such occlusion devices, and methods for treating a subject using the occlusion devices. The devices generally include a wire having shape memory properties and a flexible membranous material disposed about the wire. Some embodiments include a lateral fringe on the membranous material. Some embodiments include a fluid capture cup affixed to the wire.

Abstract: A needle catheter configured for injecting an agent into a wall of a patient's body cavity, which directs a needle from the distal tip of the catheter into the wall of the body cavity at an angle relative to the axis of the shaft. The resulting angled injection pathway improves the retention of the agent in the body cavity wall, while keeping a distal section of the catheter substantially perpendicular to the body cavity wall for optimal push against the tissue at the injection site.

Abstract: An apparatus includes a catheter for an intrathecal drug delivery system and a stylet having a curved forward end. Preferably, the curved forward end has a shape in the form of a “J” or a “C.” Also preferably, the catheter has a distal end that conforms to the curved forward end of the stylet. Thus, the present invention provides a catheter having a blunt forward end that minimizes the risk of penetrating the substance of the spinal cord. Additionally, the curved forward end of the stylet can be formed of a springy material so that it straightens out during the processes of insertion through a guide needle and retraction from the needle.

Abstract: A tissue marking apparatus includes a marker introducer that has a cannula and a stylet. The cannula has a lumen and a marker exit port. The stylet is slidably received in the lumen. The stylet has a distal end. A tissue marker is configured to be received in the lumen distal to the distal end of the stylet. The tissue marker is a drug-eluting tissue marker for marking a site in a tissue mass, and has a drug-eluting portion having a drug for release to the site and a material that can be imaged using an imaging technique.

Abstract: The invention encompasses a catheter having an outer surface, a distal end, and at least one interior lumen, wherein the outer surface includes multiple aspiration passageways in fluid communication with an interior lumen. A preferred embodiment comprises multiple aspiration passageways formed into a helical pattern.

Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.

Abstract: Methods, devices, and systems are provided for guiding tumor movement, particularly in vivo for treatment of patients. The method may include implanting into a tissue site where tumor cells are present a device having one or more surface structures or substrates, such as aligned nanofibers, which provide physical guidance cues for directing the migration of the tumor cells from the first tissue location to a selected second location, for tumor cell extraction or death. The devices and systems may include a cytotoxic agent for contacting tumor cells migrated via the substrate. All or a portion of the at least one substrate may include one or more biochemical cues, such as a coating of laminin or another protein, which may be provided in a concentration gradient to facilitate uni-directional tumor cell migration.

Abstract: Distal access aspiration guide catheter system and methods for delivering implantable devices, catheters, or substances in or near and/or restoring flow through body lumens, such as blood vessel lumens are described. A distal access aspiration guide catheter having a proximal, medial, and distal possessing high flexibility, high resistance to kinking and a large lumen to wall thickness ratio.

Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.

Abstract: According to one embodiment, a cannula assembly may include a cannula module and an inserter module. In the pre-operational state the cannula is retracted with respect to the skin-contacting surface. In operational state the cannula projects beyond the skin-contacting surface. The inserter module may include an energy store and an activation mechanism. When the energy store is at least partially discharged, the stored potential energy is transformed to kinetic energy that moves the cannula from the pre-operational state to the operational state. The activation mechanism is triggerable from outside the cannula assembly with a trigger device. The activation mechanism prevents the energy store from being discharged before it is triggered by the trigger device, and enables the energy store to be discharge after it is triggered by the trigger device to force the cannula from the pre-operational state into the operational state.

Abstract: An apparatus, system, and method for improving force and torque sensing and feedback to the surgeon performing a telerobotic surgery are provided. In one embodiment, a surgical instrument, a robotic surgical system, a cannula, a cannula seal, and a method for improved sensing of z-axis forces on a robotic surgical instrument are disclosed.