Means For Treating Eye Or Surface Of Ocular Cavity Patents (Class 604/294)
- Having means for aerating liquid (Class 604/296)
- Having means for scavenging liquid after contact with eye (Class 604/297)
- Having means for metering liquid flow to eye (Class 604/298)
- Having means for preventing contact of liquid with syringe bulb (Class 604/299)
- Having means for positioning liquid dispenser relative to eye (Class 604/300)
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Patent number: 8491528Abstract: Devices, systems, and methods interface a cassette with an eye treatment system console to provide coupling between the console and an eye treatment probe. The console may receive the cassette using a driven axial translation linkage that inhibits rotation of the cassette. The cassette may facilitate accurately positioning of a pressure sensor relative to a the console by allowing sliding movement between the sensor and a cassette body. Multiple peristaltic drives may be mounted to the console so that their rotors rotate about a common axis. An integrated mount structure may support and/or position components of the console which will interface with cassette, and an axially compressible vacuum connector of the console seal to a tapered vacuum coupler of the cassette.Type: GrantFiled: November 9, 2006Date of Patent: July 23, 2013Assignee: Abbott Medical Optics Inc.Inventors: John I. Muri, Craig Edwards
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Publication number: 20130184662Abstract: The present invention provides systems and methods for protecting a wound and managing exudate released from the wound comprising a dressing having a support cushion for surrounding the wound and periwound region; a wicking strip for application in the periwound region between the support cushion and the wound; and a reservoir for application over the wicking strip, the wicking strip configured to transfer exudate from the wound to the reservoir, where the exudate is sequestered. Various alternative embodiments are described in which the wicking strip may be custom-fit to approximate an irregular wound margin, to apply a preferred pressure gradient to the periwound regions, to periodically apply fluids to the wound bed or to apply negative pressure wound therapy. Methods of applying the dressing also are provided.Type: ApplicationFiled: December 7, 2012Publication date: July 18, 2013Applicant: Aalnex, Inc.Inventor: Aalnex, Inc.
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Patent number: 8480639Abstract: A container containing a fluid for depositing the fluid drop-by-drop into a user's eye, includes a mirror element for reflecting the eye to assist in accurately dispensing the eye drops into the eye. The mirror element may be hingedly attached and rotatable from a closed position to a predetermined open position. Alternatively, the mirror may be detachably attached at a first position adjacent the container and relocatable to a second angularly displaced position to provide a reflection of the eye receiving the eye drops.Type: GrantFiled: November 8, 2011Date of Patent: July 9, 2013Inventors: Vittorio Tedesco Zammarano, Adam Goldfine
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Patent number: 8480638Abstract: The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.Type: GrantFiled: October 4, 2007Date of Patent: July 9, 2013Assignee: Aciont, Inc.Inventors: Anthony L. Tuitupou, John W. Higuchi
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Publication number: 20130172829Abstract: Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin.Type: ApplicationFiled: October 5, 2012Publication date: July 4, 2013Applicant: SIGHT SCIENCES, INC.Inventor: SIGHT SCIENCES, INC.
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Patent number: 8475433Abstract: The invention relates to a suction ring (2) for ophthalmic surgery, with a first suction region (4), which is designed to suck the suction ring onto an eye (18), and with a second suction region (10), which is designed to aspirate a functional element (12). The functional element and/or the suction ring may exhibit measuring means. The functional element may be formed in the manner of a container, so that it can receive a liquid which in operation is located between the cornea of the eye and a lens.Type: GrantFiled: March 13, 2008Date of Patent: July 2, 2013Assignee: WaveLight AGInventors: Michael Mrochen, Michael Büeler, Christof Donitzky, Christian Wüllner
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Patent number: 8469934Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.Type: GrantFiled: January 25, 2011Date of Patent: June 25, 2013Assignee: Alcon Research, Ltd.Inventors: Alan L. Weiner, Bhagwati P. Kabra
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Patent number: 8460242Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.Type: GrantFiled: January 9, 2008Date of Patent: June 11, 2013Assignees: Fovea Pharmaceuticals, Foundation Ophtalmologiqueadolphe de RothschildInventors: Michel Paques, Pierre Roy
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Patent number: 8454582Abstract: Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.Type: GrantFiled: December 29, 2010Date of Patent: June 4, 2013Assignee: Surmodics, Inc.Inventors: Eugene deJuan, Signe E. Varner, Laurie R. Lawin
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Patent number: 8452391Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.Type: GrantFiled: December 15, 2011Date of Patent: May 28, 2013Assignee: EyeGate Pharma S.A.S.Inventor: Pierre Roy
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Publication number: 20130131612Abstract: Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end.Type: ApplicationFiled: November 21, 2012Publication date: May 23, 2013Applicant: Johnson & Johnson Vison Care, Inc.Inventor: Johnson & Johnson Vison Care, Inc.
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Publication number: 20130131611Abstract: An apparatus and method for dispersing fluid from a fluid dispersal line is provided. The method comprises initiating operation of the medical apparatus, determining whether fluid has been dispersed from the medical apparatus via the fluid dispersal line since said initiating occurred, and assessing whether fluid is available in the fluid dispersal line. If fluid has not been dispersed from the medical apparatus since said initiating occurred and fluid is not available in the fluid dispersal line, the method includes distributing a commanded quantity of fluid plus an amount of fluid determined to fill the fluid dispersal line. Otherwise the method disperses only the commanded quantity of fluid.Type: ApplicationFiled: November 18, 2011Publication date: May 23, 2013Applicant: Abbott Medical Optics Inc.Inventors: James W. Staggs, Catherine P. Ha, Wayne S. Wong
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Publication number: 20130123718Abstract: Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end.Type: ApplicationFiled: November 21, 2012Publication date: May 16, 2013Applicant: Johnson & Johnson Vision Care, Inc.Inventor: Johnson & Johnson Vision Care, Inc.
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Patent number: 8440217Abstract: A contact lens product, a method and system for forming the contact lens product, and a method of using the contact lens product. The contact lens product includes a soft disposable contact lens loaded with a drug and the carriers which carry the drug. The lens has a mechanical and optical structure formed by the core polymer included within the lens. The contact lens product is configured to have the drug released from its carrier continuously into an eye of a mammal while the contact lens product is adhered to the eye of the mammal during a continuous period of time, the drug being configured to treat or prevent at least one adverse condition of the eye of the mammal during the continuous period of time. The mammal may be a human being or a veterinary animal.Type: GrantFiled: June 15, 2005Date of Patent: May 14, 2013Inventors: Mawaheb M. El-Naggar, Shaker A. Mousa
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Patent number: 8439865Abstract: Punctal plugs for delivering therapeutic agents to the eye have a body with a portion into which the therapeutic agent is loaded and a conical anchor portion at an end of the plug.Type: GrantFiled: March 29, 2010Date of Patent: May 14, 2013Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Victor Lust, Phillip King Parnell, Sr., Vincent G. McAteer, Brian Schwam, Hassan Chaouk
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Patent number: 8435220Abstract: An emergency eyewash station is disclosed. The emergency eyewash station includes a reservoir containing an eyewash fluid and a mechanism for dispensing the eyewash fluid from the reservoir to wash an injured person's eyes. An expandable container is configured and arranged to collect used eyewash fluid after the eyewash fluid has been dispensed to wash the injured person's eyes. The station can be further enhanced by equipping the expandable container with a pair of straps configured to compress the reservoir thereby providing a gravity assist to dispensing eyewash fluid.Type: GrantFiled: October 23, 2006Date of Patent: May 7, 2013Assignee: Sperian Eye and Face Protection, Inc. a Delaware corporationInventors: Daniel P. Smith, David J. Copeland, Michael C. Pereira
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Patent number: 8433117Abstract: An embodiment of the invention provides a method that captures a diagnostic image of a retina having at least one lesion, wherein the lesion includes a plurality of spots to be treated. Information is received from a user interface, wherein the information includes a duration, intensity, and/or wavelength of treatment for each of the spots. A real-time image of the retina is captured; and, a composite image is created by linking the diagnostic image to the real-time image. At least one updated real-time image of the retina is obtained using eye tracking and/or image stabilization; and, an annotated image is created by modifying the composite image based on the updated real-time image. A localized laser beam is delivered to each of the spots according to the information, the composite image, and the annotated image.Type: GrantFiled: November 21, 2009Date of Patent: April 30, 2013Assignee: The United States of America as represented by the Secretary of the ArmyInventor: Henry Hacker
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Patent number: 8430853Abstract: Described and illustrated are various insertion instruments, cap, plug, method and kit. In one aspect, a cap for a punctal insertion instrument is shown and described. In a further aspect, a punctum plug insertion system that includes the instrument and the cap is provided. In yet a further aspect, a method of releasing a punctum plug from a plug holder is provided. Additionally, a kit that contains the plug insertion instrument, cap, plugs, and instructions for use is provided.Type: GrantFiled: February 5, 2010Date of Patent: April 30, 2013Assignee: Johnson & Johnson Vision Care, Inc.Inventors: Victor Lust, Oscar P. L. Boel, Hassan Chaouk, Brian Schwam, Stephen R. Beaton, Vincent G. McAteer
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Patent number: 8425473Abstract: The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.Type: GrantFiled: January 23, 2009Date of Patent: April 23, 2013Assignee: iScience Interventional CorporationInventors: Friedrich Ho, Stanley R. Conston, Ronald K. Yamamoto
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Publication number: 20130090611Abstract: Punctal plugs for delivering therapeutic agents have a body, a portion into which the therapeutic agent is held, a winding about the body, and an enlarged portion or anchor at an end.Type: ApplicationFiled: November 21, 2012Publication date: April 11, 2013Applicant: Johnson & Johnson Vision Care, Inc.Inventor: Johnson & Johnson Vision Care, Inc.
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Publication number: 20130085459Abstract: This invention provides for a method and an EMDU used to dispense precise quantities of liquids with an image sensor being capable of providing feedback to the user as to both, when an eye is properly aligned with the EMDU, and to detect and track the quantity of the dose administered on to the eye.Type: ApplicationFiled: October 1, 2012Publication date: April 4, 2013Applicant: JOHNSON & JOHNSON VISION CARE, INC.Inventors: Leslie A. Voss, Catie A. Morley, Gary S. Hall
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Publication number: 20130066283Abstract: Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment.Type: ApplicationFiled: October 22, 2010Publication date: March 14, 2013Applicant: NexisVision, Inc.Inventors: Yair Alster, Hanson S. Gifford, Cary J. Reich, Eugene de Juan, JR., John A. Scholl, Jose D. Alejandro, Douglas Sutton, Omer Rafaeli
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Patent number: 8388601Abstract: The invention relates to method of preparing a viscoelastic therapeutic liquid comprising a viscoelastic agent and a homogenously distributed therapeutically active agent, wherein the therapeutically active agent is distributed throughout the viscoelastic compound when the viscoelastic compound is in dry form. In one embodiment of the invention, the viscoelastic compound in dry form is mixed with an aqueous solution of the therapeutically active agent. The invention further relates to utilities of homogenous viscoelastic compositions in therapeutic applications including ophthalmic surgery.Type: GrantFiled: September 21, 2005Date of Patent: March 5, 2013Assignee: AMO Groningen B.V.Inventors: Thom Terwee, Sverker Norrby, Robert Shimizu, Rolf Bergman
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Patent number: 8372036Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber to hold a substance (e.g., a drug) to be injected into an eye, a thermal feedback layer with at least one thermal sensor, and a temperature control layer to apply or remove heat from the dispensing chamber. In some embodiments, the thermal feedback layer and the temperature control layer may be coupled to each other and/or coupled to the dispensing chamber. In some embodiments, at least one of the thermal sensors may be secured between the temperature control layer and the dispensing chamber using a thermal adhesive.Type: GrantFiled: May 5, 2010Date of Patent: February 12, 2013Assignee: Alcon Research, Ltd.Inventor: Cesario Pereira Dos Santos
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Patent number: 8366688Abstract: A sterilized non-discolored eyelid cleansing pad, which has been sterilized by exposure to ?-radiation in a dose level of 2 Mrad.Type: GrantFiled: June 28, 2006Date of Patent: February 5, 2013Assignee: Fischer Pharmaceuticals Ltd.Inventor: Josef Pesso
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Patent number: 8366689Abstract: In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils.Type: GrantFiled: September 30, 2009Date of Patent: February 5, 2013Assignee: Avedro, Inc.Inventors: John Marshall, Ali Hussein, David Muller
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Patent number: 8364232Abstract: A plug capable of providing information relating to a physical or chemical property of a body fluid, or the presence or amount of a molecular component therein in a living organism is disclosed. Specifically, one embodiment plug is capable of being inserted into a portion of a human eyelid in order to provide information relating to tear fluid is disclosed. This embodiment plug includes a body having a passage which allows for the natural flow of tear fluid therethrough. In addition, a sensing mechanism is provided which is capable of measuring, for example, glucose levels in the body of a patient through the analysis of the tear fluid. Such plug may further be designed so as to double as a punctal plug useful in preventing dry eye. Methods of utilizing and implanting such plugs are also disclosed.Type: GrantFiled: July 28, 2011Date of Patent: January 29, 2013Inventor: Robin A. Felder
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Publication number: 20130023838Abstract: An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc.Type: ApplicationFiled: September 17, 2012Publication date: January 24, 2013Applicant: VISTA SCIENTIFIC LLCInventors: Charles D. Leahy, Denis Labombard
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Publication number: 20130023837Abstract: A surgical tool for inserting a spile or plug into the punctal opening of a meatus such as a lacrimo-nasal canaliculus comprises an oblong, hollowed member shaped and dimensioned to be conveniently manipulated with one hand and having at one of its end a punctal opening and meatus-dilating shaft and, at the opposite end, a plug inserter. The dilating shaft has a cross-diameter substantially equal to the cross-diameter of the plug and is terminated by a conical spike. The inserter comprises a tip extending axially from the member and having, at its distal end, a cup whose internal geometry is commensurate with a cap at the proximal end of the plug. A penetration-resisting bearing surface is provided by the cup rim. The plug can be allowed to retract within the cup under the force of insertion. A steel wire running through the inserter has its distal end inserted into the cap of the plug.Type: ApplicationFiled: July 20, 2011Publication date: January 24, 2013Inventor: Bruce B. Becker
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Patent number: 8348912Abstract: The present application discloses a new and novel system and apparatus for improving the accuracy with which a person may apply eye drops to their own eye. The apparatus holds a bottle of eye drops at a fixed and certain distance above the eye, beside the nose, and below the forehead brow such that the user may easily apply eye drops consistently to one particular portion of their own eye. The apparatus sits on the nasion of the nose using a nasal bridge device and also rests on two pillars that are placed on the user's forehead. Used in such a manner, the apparatus facilitates one-handed eye drop application, facilitates both non-visual alignment and oblique alignment, and reduces reflective blinking.Type: GrantFiled: October 29, 2009Date of Patent: January 8, 2013Assignee: Anakin LLCInventors: Jeffrey Rehkemper, David T. Tse, Steven Rehkemper, Brad D. Simons, Jay Tapper
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Patent number: 8333742Abstract: Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.Type: GrantFiled: May 7, 2009Date of Patent: December 18, 2012Assignee: Glaukos CorporationInventors: Olav B. Bergheim, Morteza (Mory) Gharib
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Patent number: 8334008Abstract: A method is provided for making punctal plugs by providing a fibrous strand and extrusion or dip coating the fibrous strand with a polymeric coating and cutting the coated fibrous strand to adequate length for insertion into a mammal body conduit, vessel, cavity, canal, artery, or vein.Type: GrantFiled: June 5, 2008Date of Patent: December 18, 2012Inventor: Amad Tayebi
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Patent number: 8333741Abstract: A phacoemulsification cannula 10 includes a hub 12 for engagement with an ophthalmic surgical instrument. An elongated needle 14 having a proximal end 16 is attached to the hub 12. The cannula 10 has an aspiration lumen 20 spanning a majority of a length of a needle 14 from the proximal end towards a distal end 18. A venturi lumen 22 is formed in the needle adjacent the distal end. The venturi lumen 22 is in communication with the aspiration lumen 20 so that fluid and tissue may be aspirated through the venturi lumen 22 and the aspiration lumen 20.Type: GrantFiled: November 10, 2006Date of Patent: December 18, 2012Assignee: Bausch & Lomb IncorporatedInventors: Mario P. Gomez, Iidefonso Gonzalez, Dimas Joel Rullan
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Patent number: 8328774Abstract: A jig and a cooling fluid injection tool are provided for use in the correction of corneal shape of an eyeball. Correction of the eyeball takes place while the cornea is warmed. The jig includes a shape retention part of a sucking disc configuration having an inner surface side that contacts the eyeball and a grip part formed on an outer surface side of the shape retention part. An inner surface-sided cornea contacting section of the shape retention part is flattened and a cooling fluid injection hole passing through the grip part is formed in the center of the shape retention part with a diameter large enough for a wearer to see outside.Type: GrantFiled: May 26, 2008Date of Patent: December 11, 2012Inventors: Tokuichiro Hasegawa, Sakichi Hasegawa
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Publication number: 20120302972Abstract: The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.Type: ApplicationFiled: May 23, 2011Publication date: November 29, 2012Inventor: John W. Higuchi
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Publication number: 20120296261Abstract: Various delivery devices and methods are disclosed, including a delivery device (200) for delivering a dose substance (110) in powdered form to an eye. The device can include a pocket (100A, 100B, 100C) for holding dose substance and a propulsion system (202, 204, 908, 1004, 1006) for propelling a dose consisting of a predetermined volume of said dose substance from said pocket towards said eye, wherein one or both of said pocket and said propulsion system are configured to inhibit propulsion of particles having a size greater than a predetermined threshold to said eye.Type: ApplicationFiled: November 17, 2010Publication date: November 22, 2012Inventors: David Jonathan Townley Whitaker, Craig Harvey Nelson, David Morrison Russell, Thomas Mark Kemp, Simon Francis Brereton, Philip Andrew Dent, Paul Farenden
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Patent number: 8313472Abstract: An emergency eyewash station and dispensing structure therefore is disclosed. The emergency eyewash station includes a main body configured and arranged to hold and dispense eyewash fluid therefrom, an actuator arm assembly movable from a closed position to an open position, and a dispensing structure having an eyepiece sealed by a membrane. The eyepiece is in fluid connection with the eyewash fluid contained in the main body. The dispensing structure is removably coupled to the actuator arm assembly such that when the actuator arm assembly is moved from the closed position to the open position, the membrane is unsealed and the eyewash fluid dispenses from the eyepiece.Type: GrantFiled: March 14, 2007Date of Patent: November 20, 2012Assignee: Sperian Eye & Face Protection, Inc. a Delaware corporationInventors: Benoit Devinat, Michael C Pereira, Breck Petrillo
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Patent number: 8311624Abstract: An apparatus for delivering at least one therapeutic agent to an ocular tissue of a subject includes at least one electrode, a medicament layer including the at least one therapeutic agent, an electrical signal source, and logic configured to control the electrical signal source. The at least one electrode has oppositely disposed, dome-shaped first and second major surfaces. The first major surface is curved such that the first major surface substantially conforms to a contour of the ocular tissue when placed in contact with the ocular tissue. The medicament layer is disposed on at least a portion of the second major surface. The electrical signal source provides a signal having certain characteristics and is electrically connected to the at least one electrode. The certain characteristics comprise at least one orienting frequency and at least one motivating frequency sufficient to motivate the at least one therapeutic agent into the ocular tissue.Type: GrantFiled: September 25, 2009Date of Patent: November 13, 2012Assignee: The Cleveland Clinic FoundationInventors: Rishi P. Singh, Vadim F. Lvovich, Brian L. Davis
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Patent number: 8308701Abstract: The present invention generally relates to methods for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, methods of the invention involve inserting into an eye a deployment device configured to hold an intraocular shunt, determining that a distal portion of the device is properly positioned within the eye without use of an optical apparatus that contacts the eye, and deploying the shunt from the device.Type: GrantFiled: November 15, 2010Date of Patent: November 13, 2012Assignee: AqueSys, Inc.Inventors: Christopher Horvath, Laszlo O. Romoda, Guenther Grabner, Herbert A. Reitsamer
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Publication number: 20120283669Abstract: Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye.Type: ApplicationFiled: March 1, 2012Publication date: November 8, 2012Inventors: Bret A. Coldren, Peter Paul Willem Leonard Van Den Bekerom, Antonius Wilhelmus Maria De Laat, Johannes Wilhelmus Weekamp, Victor Lust, Gerald Yewey
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Patent number: 8303578Abstract: The invention relates to a system and a method for the treatment of a patient's eye. The system comprises a laser apparatus, a scanning apparatus and an eye tracking apparatus for determining the actual position of the patient's eye and for generating alignment data of the patient's eye relative to a reference position of the patient's eye to the laser, said eye tracking apparatus being provided with a desired treatment shot file. Said scanning apparatus is connected via a first bidirectional bus to the eye tracking apparatus, said laser apparatus is connected via a second bidirectional bus to the eye tracking apparatus. The eye tracking apparatus adjusts the position data for each shot based on said alignment data of the patient's eye and provides aiming control signals representative of the target position data to the scanning apparatus for said shot via said first bidirectional bus.Type: GrantFiled: September 27, 2006Date of Patent: November 6, 2012Assignee: Technolas Perfect Vision GmbHInventors: Stefan Lang, Roland Toennies
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Publication number: 20120277694Abstract: A punctal plug for insertion through a punctal aperture of an eye. The punctal plug includes a stem configured to be inserted into the punctal aperture and along a canaliculus of the eye, a stopper connected to one end of the stem, the stopper configured to seat against the punctal aperture, and a topical prostaglandin. The stem and the stopper are made from a porous or absorbent material, and wherein the material is saturated with the topical prostaglandin.Type: ApplicationFiled: June 26, 2012Publication date: November 1, 2012Applicant: QLT INC.Inventors: Steven A. Odrich, Liane C. Glazer
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Publication number: 20120271252Abstract: Disclosed is a medical fluid nozzle which makes fluid drops less likely to remain at its tip portion after the medical fluid is dropped. The medical fluid nozzle 1 is a substantially cylindrical shape with a tip surface formed in a substantially planar shape. An annular ridge 10 is formed along the circumferential direction at the tip portion of the medical fluid nozzle 1. The ridge 10 is formed so as to be continuous with the tip surface of the medical fluid nozzle 1 and has an extended surface 11 formed with an increased diameter so as to be flush with the tip surface of the medical fluid nozzle 1.Type: ApplicationFiled: September 24, 2010Publication date: October 25, 2012Applicant: Senju Pharmaceutical Co., Ltd.Inventor: Tadashi Otsuka
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Patent number: 8287504Abstract: An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially identical to a radius of curvature of the one of the superior sclera and inferior sclera of the eye. In one embodiment, the ocular device serves as an ocular drug delivery device and contains an active pharmaceutical agent, a lubricant, etc.Type: GrantFiled: July 22, 2010Date of Patent: October 16, 2012Assignee: Vista Scientific LLCInventors: Charles D. Leahy, Denis Labombard
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Patent number: 8287505Abstract: A dispensing tip apparatus for an eye drop dispenser to administer topical ophthalmic solutions is described. The apparatus integrates an ophthalmic solution-dispensing tip with an optical gauging assembly. The tip provides continuous visual feedback about it orientation and relationship to the eye. The dispensing tip when attached to any standard topical ophthalmic solution dispensing bottle or reservoir enables the user to view a target, visually align the dispenser tip, and administer an eye drop with precision. There is also a visual feedback by which the dispenser tip is prevented from gaining too close proximity and contacting the eye, thus preventing contamination of the medication and its dispenser. The visual feedback can also contain textual or graphic information that serves as a promotional advertisement. The is assembly can be attached to the neck of an eye drop bottle or attached to the tip of an eye drop bottle.Type: GrantFiled: February 23, 2010Date of Patent: October 16, 2012Inventor: Jerrold Scott Pine
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Patent number: 8287494Abstract: Intravitreal injection devices include an injection assembly adapted to receive an injector, and an alignment guide adapted to facilitate placement of the injector relative to a patient's eye for injecting an injectant therein. The injection assembly, in response to a user input, is adapted to automatically and sequentially first, translate the injector into the patient's eye, and then second, dispense the injectant from the injector. In some embodiments the injector is a typical syringe. Some embodiments are adapted to receive syringes having different configurations. Methods of injecting an injectant into a patient's eye are also provided.Type: GrantFiled: March 23, 2010Date of Patent: October 16, 2012Inventor: Colin Ma
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Publication number: 20120253299Abstract: A multi-piece punctal plug has one a superficial plug removably connected to an anchor plug deeper in the naso-lacrimal canaliculus. The anchor is fixed to the wall of the lacrimal duct while the superficial plug is axially and detachably secured to the anchor plug so that the multi-plug complex may be inserted or removed together as one, or the superficial plug may be detached separately and replaced securely without disturbing the anchor. Removal and insertion is accomplished by a specific tool having an end for reversibly engaging the plugs.Type: ApplicationFiled: May 23, 2012Publication date: October 4, 2012Inventor: Steven Odrich
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Publication number: 20120245539Abstract: Lacrimal implants providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body, including first and second portions, extending from a proximal end of the first portion to a distal end of the second portion. The second portion includes a retention projection. The implant body can also include a cavity longitudinally extending from the proximal end of the first portion toward the second portion, wherein the cavity is shaped and sized to receive an insertable actuator, and wherein the retention projection is configured to bias outward or change orientation when the insertable actuator is seated within the cavity.Type: ApplicationFiled: November 26, 2010Publication date: September 27, 2012Applicant: QLT INC.Inventors: Sascha K. Zarins, David J. Scott, David Tholfsen
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Publication number: 20120245505Abstract: Described herein are intracameral drug and/or therapeutic bioactive agent delivery devices comprising a substantially cylindrical structure for at least partial placement into the anterior chamber of an eye The intracameral delivery devices have a sustained release material associated with at least a portion of the device and at least one drug and/or therapeutic bioactive agent associated with said sustained release material.Type: ApplicationFiled: December 14, 2010Publication date: September 27, 2012Inventors: Michael R. Robinson, Werhner C. Orilla, Zoran Novakovic, James A. Burke, Alazar N. Ghebremeskel, Lon T. Spada
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Patent number: 8273050Abstract: Ocular implants and methods of treating ocular disorders are provided. One method involves inserting an implant into an anterior chamber of an eye. The implant has a therapeutic drug or agent and is advanced within the anterior chamber to a location posterior to a cornea of the eye. At least a portion of the implant is placed into eye tissue at this location. The therapeutic drug of the implant is exposed to aqueous humor. In one method, an anchor is utilized to retain the implant in eye tissue.Type: GrantFiled: July 12, 2004Date of Patent: September 25, 2012Assignee: Glaukos CorporationInventors: Olav B. Bergheim, Morteza (Mory) Gharib