Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.

Abstract: A method of pneumatically operating a dialysis system includes (i) pumping air in a first valve state from a pneumatic pump to operate a component of the dialysis system, and (ii) recirculating air in a second valve state by pumping air from an outlet of the pneumatic pump to an inlet of the pneumatic pump to minimize at least one of a noise pitch or noise amplitude when switching from the second valve state to the first valve state.

Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.

Abstract: Splitable-tip catheters are disclosed with bioresorbable adhesive to provide spatial separation of distal tip elements during use. The invention can be particularly useful in hemodialysis applications where it is desirable to separate blood extraction and return lumens. The adhesive facilitates insertion of the distal end of the catheter as an assembly, e.g., into a blood vessel using a single guidewire, while the bioresorbable nature of the adhesive allows the tip elements to separate in vivo.

Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

Abstract: A blood-collection system configured to permit selection of either collection and disposal of shed blood from a patient or collection and processing of shed blood for autologous transfusion back to the patient includes an automated blood-processing machine. The system may also include a blood-collection reservoir, a separation chamber, and a fluid conduit. The blood-collection reservoir may be engageable with the blood-processing machine so that the machine can identify and report the presence of blood in the reservoir. The separation chamber may also be engageable with the blood processing machine. The fluid conduit may be configured to selectively join the reservoir to the separation chamber by a quick-connect coupling.

Abstract: A cardiopulmonary bypass system utilizing membrane-based reciprocating positive displacement blood pumps (“pod pumps”). In one aspect, the pod pumps are constructed to provide reduced shear forces on the blood being pumped. In another aspect blood flow through the pod pumps can be controlled by a controller using information from pressure sensors in the control chamber of the pod pumps. In another aspect, the pod pumps are included on a disposable unit that can be received and held by a receptacle means on a base unit, the base unit also providing pressurized control fluid to the pod pumps on the disposable unit through the receptacle means.

Abstract: Devices, systems, and methods for providing retroperfusion to at least one ischemic tissue in a minimally invasive manner are disclosed. At least some of the embodiments disclosed herein enable an anastomosis to be formed between a vein and an artery without the use of sutures and through a non-invasive procedure. In addition, various disclosed embodiments provide a cannula device comprising a Y-configuration for bifurcating arterial flow between an anastomosis and the underlying artery. The devices, systems and methods herein can further provide simultaneous autoretroperfusion therapy to more than one area of an ischemic tissue.

Abstract: A device and method for determining intravascular pressure and irregular needle placement in a hemodialysis procedure include analyzing means for automatically deriving venous access pressure (VAP) at a location of venous needle insertion into the patient and determining a ratio of VAP to mean arterial pressure, where the analyzing means determines multiple VAP values over multiple time periods and determines multiple ratios, one for each VAP value. Detecting means compare each ratio to a predetermined standard ratio derived from a moving average of prior VAP ratios, where the detecting means detects irregular needle placement when elevation of the ratio above the standard ratio is indicated.

Abstract: Embodiments of the present invention relate generally to heat-exchanger systems that can be used to heat or cool a fluid such as blood. Pod pumps that provide low shear and low turbulence may be used in such systems, particularly for systems that pump blood. A certain heat-exchanger system used to heat blood or other fluids may be used to provide whole-body hyperthermic treatments or regional hyperthermic chemotherapy treatments. A disposable unit may be used to separate the fluid path from the fluid control systems. The disposable unit typically includes a heat-exchanger component that is received by a corresponding heat exchanger in a base unit. Fluid pumped through the heat-exchanger component is heated by the heat exchanger.

Abstract: Coil occluder devices and systems and methods of using the same. In an exemplary embodiment of an occluder system of the present disclosure, the occluder system comprises an occluder device comprising a coil having at least a first, uncompressed configuration and a second, compressed configuration, wherein the coil in the first, uncompressed configuration is configured to fit within a delivery mechanism sized and shaped to fit within a mammalian luminal organ, and wherein the coil in the second, compressed configuration is configured to occlude a mammalian luminal organ, and a delivery mechanism sized and shaped to fit within the mammalian luminal organ, the delivery mechanism configured to receive the coil in the first, uncompressed configuration within a lumen defined within the delivery mechanism.

Abstract: A method and apparatus for performing coronary perfusion and cardiac reoxygenation that enables accurate control of oxygen levels in blood used for the coronary circulation. Deoxygenated blood and oxygenated blood are collected and oxygen levels are measured by sensors. The deoxygenated and oxygenated blood is then mixed and the mixed blood is measured by another sensor. The sensors provide data used to provide real-time oxygen level measurement and adjustment for blood supplied for coronary circulation.

Abstract: A dialysis fluid pressure manifold system includes a plurality of pump and valve chambers controlling a flow of dialysis fluid; a header including a plurality of pneumatic passageways, each passageway in pneumatic communication with one of the pump or valve chambers; a plurality of electrically actuated pneumatic valves; and a plate defining a plurality of pneumatic apertures, each pneumatic aperture in pneumatic communication with one of the plurality of electrically actuated pneumatic valves, the plate providing the apertures each with an o-ring seal for airtight connection with the pneumatic passageways of the header.

Abstract: A blood supply flow rate controlling device (2), which is a device for controlling the blood supply flow rate in an extracorporeal circulation device connected to a living body (10), includes rotational frequency detecting means that detects the rotational frequency of the centrifugal pump (40) of the extracorporeal circulation device, inlet pressure detecting means and outlet pressure detecting means that detect the inlet pressure and the outlet pressure of the centrifugal pump (40), respectively, flow rate regulating means that regulates a flow rate of blood supplied to the living body by adjusting a flow path cross section area of the blood circulation circuit (20), and controlling means that controls the flow rate regulating means.

Abstract: A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.

Abstract: The present invention relates to an apparatus for making extracorporeal blood circulation available, in particular a heart-lung machine, comprising a venous connection and an arterial connection, between which a blood reservoir, a blood pump and a bubble detector for the detection of air bubbles are provided, with, downstream of the bubble detector, an arterial line leading to the arterial connection via an arterial clamp and a bypass leading via a bypass clamp back into the blood reservoir which is connected to a pump extracting air from the blood reservoir. In addition, the present invention relates to a method of operating such an apparatus.

Abstract: A multi-path catheter includes an elongate tubular member and a withdrawal pathway along which unfiltered fluid is withdrawn in a distal to proximal direction. The withdrawal pathway originates at a distal point and is at least partially defined by the elongate tubular member. The elongate tubular member also defines, at least partially, at least one infusion pathway along which filtered fluid is returned in a proximal to distal direction. The at least one infusion pathway extends distally beyond the withdrawal pathway. First and second legs of the elongate tubular member are positioned on opposing sides of the withdrawal pathway at the distal point, and the at least one infusion pathway is at least partially defined by one of the first and second legs. The first and second legs have outer walls that are unattached to one another at distal ends thereof.

Abstract: Devices, systems, and methods for organ retroperfusion. In at least one embodiment of a method of organ perfusion of the present disclosure, the method comprises the steps of positioning at least part of a first catheter having a cannula within an artery of a patient, the first catheter configured to permit arterial blood to flow therethrough and further configured to permit a portion of the arterial blood to flow through the cannula, positioning at least part of a second catheter within a vein of the patient at or near a target organ, the second catheter configured to receive some or all of the portion of the arterial blood, and connecting the cannula of the first catheter to a portion of the second catheter so that some or all of the portion of the arterial blood flowing through the cannula is provided into the vein to treat a condition or disease of the target organ.

Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump 4, a venous blood circuit 3, a dialysate introduction line L1, a dialysate discharge line L2, a substitution line L3, and a substitution pump 9 that supplies the dialysate flowing in the substitution line L3 to the arterial blood circuit 2. A control device (11) estimates or measures the concentration of blood in a dilution channel section A. The control device (11) controls the volume of dialysate supplied by the substitution pump 9 on the basis of the estimated or measured blood concentration.

Abstract: A system and method for removing gas bubbles from blood during circulatory assist procedures. An active filter apparatus forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter.

Abstract: This document relates to methods and materials for providing blood flow for a blood pump recipient. For example, cannulae that can be connected to the circulatory system of a mammal and can be used in conjunction with a blood pump (e.g., an assist device) are provided.

Abstract: A system for measuring of cardiac blood flow balance parameter between the right chamber of the heart and the left chamber of the heart includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating a full arterial pulse signal, an arterio-venous pulse signal, and a balance parameter. A computational device is responsive to the balance parameter for further generating a set of physiological parameters. A display station device is responsive to the set of physiological parameters from the computational device for displaying meaningful information.

Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.

Abstract: A hemodialysis system includes (i) a dialyzer; (ii) a blood pump; (iii) a blood cassette operatively connected to the dialyzer and the blood pump; (iv) a dialysate heater; (v) first and second peristaltic dialysate pumps; and (vi) a dialysate cassette separate from the blood cassette, the dialysate cassette including an organizer configured to support a drain tube, a to-dialyzer tube and a from-dialyzer tube, the cassette further including a first pumping tube, a second pumping tube and an inline fluid heating pathway, the cassette when mounted for operation orienting (a) the first pumping tube for operation with the first peristaltic dialysate pump, (b) the second pumping tube for operation with the second peristaltic dialysate pump and (c) the fluid heating pathway for operation with the dialysate heater.

Abstract: The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.

Abstract: A coupler includes a conductive polymer material that is so constructed and arranged to join tubing, wherein the conductive polymer material includes a conductive polymer component selected from the group consisting of polyaniline, polypyrrole, polythiophenes, polyethylenedioxythiophene, poly(p-phenylene vinylene) and mixtures thereof.

Abstract: The present invention concerns a multipart fluid system for use in CRRT, wherein the multipart fluid system comprises an anticoagulation fluid and at least one fluid from the group consisting of a dialysis fluid and an infusion fluid. According to the invention the anticoagulation fluid comprises at least 8 mM citrate, and the dialysis fluid and/or infusion fluid comprises 2-8 mM citrate and 1-5 mM total calcium. The present invention further concerns a system for regional citrate anticoagulation in an extracorporeal blood circuit.

Abstract: A medical apparatus comprises a machine for treatment of fluids provided with means (3) for treating a patient's blood which exhibit a control unit (4) for sending command signals and receiving information relating to the treatment under way on the patient. A remote unit (7) is included which enable the remote unit (7) to selectively take control of a predetermined number of functions of the medical machine. The control unit (4) of the medical machine is predisposed to selectively inhibit the remote control means (10) from taking or maintaining control of the functions of the medical machine in consequence of the operating configuration of the machine.

Abstract: A blood purification apparatus has a dialyzer (1), an arterial blood circuit (2) with a blood pump (4), a venous blood circuit (3), a dialysis fluid introduction line (L1), a dialysis fluid discharge line (L2), a dialysate infusing line (L8), and a dialysate infusing pump (13). A closed circuit is formed in the flow route of the dialysis fluid on the dialysis fluid introduction line (L1) side including a predetermined part where a collection port (11) is formed. A testing process is performed to confirm the connection of the dialysate infusing line (L8) to the collection port (11) by measuring fluid pressure within the closed circuit while driving the dialysate infusing pump (13).

Abstract: The present invention relates to a method for controlling or regulating an apparatus for extracorporeally treating blood in an extracorporeal blood circuit while adding citrate and calcium for the purpose of anticoagulation. The apparatus comprises a dispensing device for dispensing a calcium solution into the extracorporeal blood circuit. The method encompasses outputting a signal to the dispensing device for altering a setting of the dispensing device, in which the setting corresponds to or effects an addition of calcium, a calcium dosage, concentration, amount or rate. The method further encompasses defining or altering the signal with regard to a calcium content or a calcium concentration of a substituate solution used in extracorporeally treating the blood, and detecting the range of values of permissible or allowed settings for the calcium introduced or to be introduced into the extracorporeal blood circuit by the dispensing device, particularly its amount, concentration or dosage.

Abstract: A catheter assembly for use in accessing a vasculature of a patient during renal replacement or other therapies is disclosed. In one embodiment, the catheter assembly includes a catheter body that defines first and second lumens. The catheter body defines a distal tip region that includes a venous lateral opening that is in fluid communication with the first lumen and an arterial lateral opening that is in fluid communication with the second lumen.

Abstract: The disclosure pertains to a perfusion system that is easy to set-up, use and monitor during a bypass procedure. In some embodiments, the disclosure pertains to a perfusion system in which at least some of the disposable components used with the perfusion system are configured to be able to communicate set-up and/or operational parameters to the perfusion system in order to unlock further functionality within the perfusion system.

Abstract: In a process for testing filters (4) and (13) of treatment fluid of a hemodiafiltration apparatus (1), each filter has a wet semipermeable membrane (5, 14) which separates a gas-filled first chamber (6 and 15) from a liquid-filled second chamber (7 and 16). The first chambers are pressurised by a pump (19) supplying air, while the second chambers are placed in depression by a drainage pump (17) of used dialysis fluid. A first closed system is formed which includes the first chambers and a second closed system is formed which includes the second chambers. Two pressure gauges (P1 and P2) monitor the pressure in the two closed systems for a predetermined time. The monitoring provides indications relating to the filter integrity.

Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient.

Abstract: The described system and method for blood treatment are configured to detect at least two hemodynamic parameters, for example the blood pressure and the relative blood volume, during the blood treatment. At least two fuzzy modules receive measuring values of the hemodynamic parameters as input variables, wherein the output signals transmitted by the fuzzy modules are weighted by at least one weighting module. A setting means effectuates setting of at least one variable, for example an ultrafiltration rate, a dialysis fluid conductivity or a dialysis fluid temperature, in response to the output signal transmitted by the weighting module. In this way, e.g. threatening intradialytic hypotensive episodes can be detected and avoided. The system can be designed as a dialyser for hemodialysis, hemofiltration or hemodiafiltration.

Abstract: One disclosed embodiment comprises a method for treating lesions in the carotid artery of a mammalian body. The method comprises transcervical access and blocking of blood flow through the common carotid artery (with or without blocking of blood flow through the external carotid artery), shunting blood from the internal carotid artery and treating the lesion in the carotid artery.

Abstract: A proposed blood treatment apparatus includes a blood treatment unit, at least one fluid pump and at least one blood pump. The fluid pumps are configured to pass blood treatment fluid through the blood treatment unit, while the blood pumps are configured to extract untreated blood from a blood source, e.g. a patient, pass the extracted blood through the blood treatment unit and deliver treated blood to a target vessel, e.g. likewise represented by a patient. Each blood pump includes a pumping chamber, which is separated into a first accumulation container and a second accumulation container by a flexible member. The flexible member is further movable within the pumping chamber so as to vary a volume relationship between the first and second accumulation containers. The second accumulation container is configured to receive an amount of blood treatment fluid to act on the flexible member and thus pump blood from the first accumulation container.

Abstract: A method for reducing the number of selected antibodies in a subject's blood, the method comprising removing blood from the subject, passing the blood along an enclosed pathway, wherein the pathway comprises one or more semi-permeable hollow fibers with one or more membranes having surfaces positioned substantially perpendicular to the length of the one or more hollow fiber and antigens specific for the antibodies immobilized on the one or more membranes, returning the treated blood to the internal circulation of the subject, wherein the returned treated blood has a reduced number of selected antibodies compared to before treatment.

Abstract: A plurality of heat transfer pipes have a circumferential portion arranged at a short distance from an inner surface of a heat exchanger case while they are bundled to form a pipe group and a first chord which retracts toward a center in a direction of cylinder diameter from an arc formed by the circumferential portion. The plurality of bundled heat transfer pipes are loaded in the exchange case such that the first chord and an inner surface of the heat exchange case on a side where a heat exchange medium inlet port is attached are opposed to each other. By making a flow of a heat exchange medium to each heat transfer pipe uniform, a heat exchanger capable of obtaining high heat exchange performance is obtained.

Abstract: The connector for a fluid line of an extracorporeal circuit comprises a tubular body which internally defines a fluid passage, a first connection port predisposed for coupling to the fluid line, a second connection port predisposed for coupling to a male Luer connector borne by an external element, and a closure element of the second connection port. The closure element is formed of a breakable membrane made in a single piece with the tubular body. On coupling, the membrane is broken by the truncoconical projection of the male Luer connector. The connector connects a service line of an extracorporeal circuit to a pressure sensor of a dialysis machine.

Abstract: A dialysis system includes a dialyzer; a blood pump coupled operably to a dialyzer; a dialysate inlet pump couple operably to a dialysate inlet of the dialyzer; a dialysate outlet pump coupled operably to a dialysate outlet of the dialyzer; a first non-invasive fluid velocity sensor positioned to sensor of inlet flowrate of dialysate pumped to the dialysate inlet by the dialysate inlet pump; and a second non-invasive fluid velocity sensor positioned to sense an outlet flowrate of dialysate pumped from the dialysate outlet by the dialysate outlet pump.

Abstract: A method and device treats cancer where blood from a cancer patient passes through an array of passageways within an interior of a chamber. The passageways include wells having porous membrane wall portions that enable a molecular-sized activating agent in a carrier fluid that enhances an immune response to pass through these porous wall portions. Pore size is such to allow the molecular-sized activating agent in the interior of the chamber to enter the wells yet prevents immune cells and cancer cells in the wells to pass through the porous wall portions into the interior of the chamber. Blood is retained in the wells so that it remains in contact with the immune cells and cancer cells for a predetermined period sufficient to enhance an immune response. Then the cells with an enhanced immune response are return to the patient.

Abstract: A method is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing device with an extra-corporeal blood circuit, comprising an arterial blood line, running from an arterial patient connection to a first chamber of a dialyzer or filter divided into said first chamber and a second chamber by a membrane and a venous blood line, running from the first chamber of the dialyzer or filter to a venous patient connection. A device is provided for monitoring the introduction of substitution fluids for an extra-corporeal blood processing unit with an extra-corporeal blood circuit and an extra-corporeal blood processing device with a device for monitoring the introduction of substitution fluids. The method and the device for monitoring the introduction of substitution fluids are based on monitoring the fluid level in the bubble trap, arranged in the venous blood line of the extra-corporeal blood circuit.

Abstract: Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.

Abstract: A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.

Abstract: A system, apparatus and methods are provided for extra-corporeal blood treatment, and in particular for establishing and maintaining a neck down differential body temperature, while maintaining near normal brain temperatures, to protect the brain from extended or extreme hypothermia or hyperthermia. A blood treatment apparatus and system is provided for differential control of brain temperature and body temperature below the neck. For example, a first bypass circuit with heat exchanger for brain blood circulation maintains a near normal blood temperature, while a second bypass circuit for below the neck blood circulation provides for thermal treatment to induce a temperature differential, e.g. hyperthermia or hypothermia, relative to brain circulation. Such systems and apparatus have application, for example, for diagnostic and therapeutic treatments using hyperthermia, particularly for treatments of extended duration or at elevated temperatures above 42° C.

Abstract: A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.

Abstract: Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include multi-stage de-airing of blood to provide automated cardiopulmonary replacement to preserve the viability or one or more organs in a clinically dead organ donor or harvested donor organ for subsequent transplantation to an organ receiver patient.

Abstract: A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.

Abstract: The present invention relates to a method for illuminating the viruses in a circulatory blood, comprising the following steps of: 1) Adding an anticoagulant into a whole blood source and establishing a circulation system for the whole blood source; 2) Withdrawing the whole blood with the anticoagulant into a plasma-separating device for a separation, when finished, directly pumping the red-blood cells back into the whole blood source and transporting the plasma into a mixing transport pump after the separation; 3) Meanwhile, pumping a photosensitizer methylene blue into the mixing transport pump so that the methylene blue is mixed with the plasma and pumped together into a plasma container; 4) Using an illumination device to illuminate the plasma in the plasma container for virus illumination, and pumping the virus-illuminated plasma into a removing device for removing off the photosensitizer; 5) The methylene blue being absorbed by the removing device and the plasma illuminated being transfused back into the