Needleless Hypodermic Injector Patents (Class 604/68)
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Patent number: 9775945Abstract: The invention relates to a bottle holder (1) for an injection or infusion device, with a bottle receiver (2) for receiving a storage bottle, and with a spike secured on the bottle holder (1) for the purpose of punching an outlet opening into the storage bottle, or a holding means (3) for applying an exchangeable spike (4). In a development of such a bottle holder with which the infusion or injection device can be equipped as easily and as quickly as possible with a filled storage bottle, the invention proposes that the bottle receiver (2) is movable with respect to the spike (4) or with respect to the holding means (3) for the spike (4), and, when the bottle receiver (2) moves in the direction of the spike (4), a storage bottle arranged in the bottle receiver (2) is placed onto the spike (4) in such a way that the spike (4) punches an outlet opening into the storage bottle.Type: GrantFiled: February 8, 2011Date of Patent: October 3, 2017Assignee: ULRICH GMBH & CO. KGInventors: Joerg Kaiser, Thomas Kranhold
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Patent number: 9731079Abstract: A drive assembly for a medication delivery device comprising a housing, a drive member moveable in the proximal direction for setting a dose of the medication and in the distal direction for delivering the dose, a piston rod driven by the drive member in the distal direction during movement of the drive member in the distal direction for delivering the dos. A restriction member for restricting proximal movement of the piston rod during proximal movement of the drive member by mechanical interaction of the restriction member with a stop feature of the piston rod. The restriction member and the stop feature are arranged for the piston rod to be moved proximally a first distance during a first proximal movement of the drive member before the restriction member and the stop feature interact mechanically.Type: GrantFiled: December 1, 2009Date of Patent: August 15, 2017Assignee: Sanofi-Aventis Deutschland GmbHInventor: David Plumptre
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Patent number: 9717853Abstract: A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the center line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm.Type: GrantFiled: May 13, 2014Date of Patent: August 1, 2017Assignee: LTS LOHMANN THERAPIE-SYSTEME AGInventor: Rudolf Matusch
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Patent number: 9706900Abstract: A needleless fluid delivery system for delivering therapeutic fluids to treatment sites within a patient. The fluid delivery system can include an automated injector source and a needleless access device. The access device can include a delivery scope and a treatment specific applicator. The automated injector source, delivery scope and applicator can be operably coupled with quick-connect style fittings so as to allow for quick replacement and maintenance of used or damaged components. The automated injector source can include a hands-free input mechanism allowing a medical professional to use both hands in manipulating the delivery scope and needleless applicator at the same time an injection is desired. The delivery scope and needleless applicator can comprise flexible or rigid lengths of tubing based on the accessibility of the treatment site. The needleless delivery system can include an imaging system for precisely position the applicator with respect to the treatment location.Type: GrantFiled: June 17, 2013Date of Patent: July 18, 2017Inventors: Suranjan Roychowdhury, Vincent G. Copa, Sidney F. Hauschild
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Patent number: 9687613Abstract: A resettable dose setting mechanism for a drug delivery device comprising a driver for driving a spindle of the drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.Type: GrantFiled: April 24, 2012Date of Patent: June 27, 2017Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: David Plumptre, Christopher Jones
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Patent number: 9682194Abstract: An injection device having a first sub-assembly comprises a housing and a chamber. The chamber is disposed within the housing and has proximal and distal ends, an inner surface and an exit aperture. The sub-assembly comprises a stopper movably disposed within the chamber. The stopper has an outer surface substantially in contact with the inner surface about its perimeter. The sub-assembly comprises a port adapted to receive a container containing a fluid. The stopper is fixed with respect to the housing and movement of the port causes movement of the exit aperture in relation to the stopper.Type: GrantFiled: June 10, 2009Date of Patent: June 20, 2017Assignee: Cilag gmBh InternationalInventors: Douglas Ivan Jennings, Rosemary Louise Burnell
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Patent number: 9662454Abstract: A resettable dose setting mechanism for a drug delivery device comprising a driver for driving a spindle of the drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.Type: GrantFiled: April 24, 2012Date of Patent: May 30, 2017Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: David Plumptre, Christopher Jones
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Patent number: 9616179Abstract: A driver for driving a spindle of a drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.Type: GrantFiled: May 28, 2010Date of Patent: April 11, 2017Assignee: SANOFI—AVENTIS DEUTSCHLAND GMBHInventors: David Plumptre, Christopher Jones
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Patent number: 9586010Abstract: An auto-injector automatically dispenses a predetermined dose of medicament upon activation. The auto-injector includes a needle cover operative to engage an injection site and activate the injector. The needle cover is configured to move from a locked retracted position prior to a medicament dispensing operation to a locked extended position after the medicament dispensing operation. The non-removable needle cover prevents contact with the needle both before and after the medicament dispensing operation.Type: GrantFiled: March 7, 2013Date of Patent: March 7, 2017Assignee: Meridian Medical Technologies, Inc.Inventors: C. Michael Mesa, Dalita Rosemarie Tomellini, Mark Bumb Bremley, Sophie Rebecca Raven, Martin Joseph Murphy, Craig Malcolm Rochford, Stephen Philip Kirkwood
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Patent number: 9545483Abstract: A drive assembly comprises a housing, a drive member moveable for setting a dose and for delivering the dose. A piston rod adapted to be driven by the drive member in the distal direction during movement of the drive member in the distal direction for dose delivery and a restriction member for restricting proximal movement of the piston rod during proximal movement of the drive member by mechanical interaction of the restriction member with a stop feature. The restriction member and stop feature arranged for the piston rod to be moved proximally a first distance during a first movement of the drive member before the restriction member and stop feature interact mechanically. The first distance the piston rod moves proximally during the first movement of the drive member is different than a subsequent distance the piston rod moves during a subsequent proximal movement of the drive member.Type: GrantFiled: December 2, 2008Date of Patent: January 17, 2017Assignee: Sanofi-Aventis Deutschland GmbHInventor: David Plumptre
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Patent number: 9517310Abstract: A resettable dose setting mechanism for a drug delivery device comprising a driver for driving a spindle of the drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.Type: GrantFiled: April 24, 2012Date of Patent: December 13, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: David Plumptre, Christopher Jones
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Patent number: 9474860Abstract: The present invention resides in a needleless syringe for injecting an injection objective substance into an injection target area of a living body without using any injection needle; the needleless syringe comprising a main syringe body; an accommodating unit which accommodates the injection objective substance by the aid of a sealing member in an accommodating chamber provided in the main syringe body; a pressurizing unit which pressurizes the injection objective substance accommodated in the accommodating unit to move or destroy the sealing member thereby so that the injection objective substance is discharged to outside; a flow passage unit which forms a discharge port with respect to the injection target area and which defines a flow passage so that the injection objective substance pressurized by the pressurizing unit is discharged via the discharge port to the injection target area; and a preparatory filling unit which fills the flow passage unit with a part of the injection objective substance accommoType: GrantFiled: February 3, 2012Date of Patent: October 25, 2016Assignee: DAICEL CORPORATIONInventors: Masahiro Haitsuka, Masayuki Ueda
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Patent number: 9421333Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.Type: GrantFiled: December 24, 2014Date of Patent: August 23, 2016Assignee: Antares Pharma, Inc.Inventors: Paul K. Wotton, Peter L. Sadowski, John W. Hayes
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Patent number: 9408972Abstract: A needle-free injection device having an outer housing and an inner housing is disclosed. The inner housing is configured to receive a needle-free syringe in one end. In addition, the inner housing is movable within the outer housing between a syringe loading position and a firing position. The device also includes an activation button operatively associated with the inner and outer housings and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position when the activation button is activated with the inner housing in the syringe loading position. Methods and apparatus for using, filing and operating the needle-free injection device are also disclosed.Type: GrantFiled: August 2, 2011Date of Patent: August 9, 2016Assignee: PharmaJet, Inc.Inventors: Chris Cappello, Matt Wixey, John W. Bingham
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Patent number: 9408979Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.Type: GrantFiled: November 19, 2015Date of Patent: August 9, 2016Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Robert Frederick Veasey, Robert Perkins, David Aubrey Plumptre
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Patent number: 9386713Abstract: Modular elements employing latches secured by linkages are disclosed. A modular element may include a chassis body in communication with a latch, control body, and control arm of the modular element. The modular element is removable from or secured to an enclosure using the latch. The latch may remain secured to the enclosure in a locked mode by being rotated to engage a control catch of a control arm of a linkage. By connecting the control arm to the control body with a rigid member connected to the control body with first and second rotary joints, the rigid member transforms a control body movement into a rotary motion of the control arm to disengage the control arm from the latch. In this manner, the modular element may be disengaged from the enclosure to facilitate upgrades or maintenance of electronic components supported by the chassis body.Type: GrantFiled: December 31, 2014Date of Patent: July 5, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Matthew A. Butterbaugh, Eric A. Eckberg, Camillo Sassano, Kevin L. Schultz, Scott A. Shurson
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Patent number: 9386736Abstract: Modular elements employing latches secured by linkages are disclosed. A modular element may include a chassis body in communication with a latch, control body, and control arm of the modular element. The modular element is removable from or secured to an enclosure using the latch. The latch may remain secured to the enclosure in a locked mode by being rotated to engage a control catch of a control arm of a linkage. By connecting the control arm to the control body with a rigid member connected to the control body with first and second rotary joints, the rigid member transforms a control body movement into a rotary motion of the control arm to disengage the control arm from the latch. In this manner, the modular element may be disengaged from the enclosure to facilitate upgrades or maintenance of electronic components supported by the chassis body.Type: GrantFiled: January 21, 2015Date of Patent: July 5, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Matthew A. Butterbaugh, Eric A. Eckberg, Camillo Sassano, Kevin L. Schultz, Scott A. Shurson
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Patent number: 9375532Abstract: Described is an injection device for administering a dose of a medicament comprising a case having a proximal end and a distal end, a carrier adapted to accommodate a syringe, and a trigger button. In a first state, the trigger button is coupled to the case and/or the carrier and abuts the distal end of the case. In an intermediate state, the case moves proximally relative to the carrier and the trigger button, and the trigger button engages the carrier. In a second state, the trigger button and the carrier move proximally relative to the case, and the trigger button disengages the carrier and engages the case.Type: GrantFiled: October 11, 2012Date of Patent: June 28, 2016Assignee: Sanofi-Aventis Deutschland GMBHInventors: Simon Francis Brereton, Thomas Kemp
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Patent number: 9333300Abstract: A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human.Type: GrantFiled: September 5, 2013Date of Patent: May 10, 2016Assignee: PHARMAJET, INC.Inventors: John Bingham, Robert Steinway
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Patent number: 9308326Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.Type: GrantFiled: September 18, 2014Date of Patent: April 12, 2016Assignee: Massachusetts Institute of TechnologyInventors: Ian W. Hunter, Andrew J. Taberner, Brian D. Hemond, Dawn M. Wendell, Nora Catherine Hogan, Nathan B. Ball
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Patent number: 9101429Abstract: The present invention is related to a technique for simultaneously forming a plurality of paste filled tunnels. The plurality of paste filled tunnels are connected to a surgical tube directly or indirectly and emptied one after another, until a desired amount of the paste is injected into a bone cavity, organ or a tissue via the surgical tube. The paste may be a bone cement paste, a drug powder paste, viscous fluid or gel. The injected bone cement paste will set in the bone cavity to act as a medical implant.Type: GrantFiled: March 2, 2012Date of Patent: August 11, 2015Inventors: Jiin-Huey Chern Lin, Chien-Ping Ju
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Patent number: 9078976Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.Type: GrantFiled: January 10, 2012Date of Patent: July 14, 2015Assignee: Sanofi-Aventis Deutschland GmbHInventors: Malcolm Boyd, Richard Letham, David Plumptre, Robert Veasey, James May, Matthew Jones, Samuel Ghazaros
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Patent number: 9044546Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.Type: GrantFiled: August 22, 2013Date of Patent: June 2, 2015Assignee: Powder Pharmaceuticals IncorporatedInventors: Nigel R. Bates, Philip T. Price
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Publication number: 20150119799Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.Type: ApplicationFiled: December 24, 2014Publication date: April 30, 2015Inventors: Paul K. Wotton, Peter L. Sadowski, John W. Hayes
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Publication number: 20150105720Abstract: A therapeutic agent injection device including an injection device for delivering a therapeutic agent to a patient having a body, the body having a patient face and an port face opposite the patient face, the port face having an introducer port including an introducer channel and an injection port including an injection channel, the introducer channel being in fluid communication with the injection channel through a cross channel, the injection channel defining an injection axis; a delivery tube for subcutaneous delivery of the therapeutic agent to the patient, the delivery tube projecting from and being generally perpendicular to the patient face, the delivery tube defining an introducer axis and being in fluid communication with the injection port; and a patch, the patch being attached to the patient face and being operable to adhesively attach to the patient; wherein the injection axis is parallel to the introducer axis.Type: ApplicationFiled: September 19, 2014Publication date: April 16, 2015Inventors: Susan McConnell Montalvo, Colin A. Chong, Hans Lickliter, Rafael Bikovsky
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Patent number: 8998842Abstract: An injection device for injecting medication to a patient, comprising a surface (5) having a through hole (3) for passage of a needle, is characterised by further comprising a capacitive proximity sensor (12, 13, 30) for detecting proximity or contact of human skin to/with said surface (5).Type: GrantFiled: November 30, 2011Date of Patent: April 7, 2015Assignee: Ares Trading S.A.Inventors: Gerhard Lauchard, Martin Reindl, Claudia-Carolin Guggenberger
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Patent number: 8998881Abstract: A method for delivering a drug into tissue includes the steps of: providing a drug delivery device having at least one nozzle and a drug contained in a portion of the device; identifying a site for delivery of the drug in or on tissue; placing a portion of the device on or near the site; and delivering the drug into the tissue at the site through at least one nozzle of the device under microjet propulsion.Type: GrantFiled: August 10, 2005Date of Patent: April 7, 2015Assignee: Alza CorporationInventor: Scott J. Gilbert
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Patent number: 8992466Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.Type: GrantFiled: December 7, 2012Date of Patent: March 31, 2015Assignee: Massachusetts Institute of TechnologyInventors: Ian W. Hunter, Andrew J. Taberner, Brian D. Hemond, Dawn M. Wendell, Nora Catherine Hogan, Nathan B. Ball
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Patent number: 8992465Abstract: A needleless injector including a body at a proximal end, a shaft extending distally from the body, at least one injection orifice at a distal end of the shaft in fluid communication with a fluid chamber at the proximal end, a pressure source in communication with the fluid chamber, and a tissue tensioner located at the distal end of the shaft proximal to the injection orifice, wherein the distal end including the tissue tensioner and injection orifice is positionable within a urethral lumen so that when the tissue tensioner is deployed, tissue of the urethra is tensioned at a location for injection of fluid from the injection orifice into the tissue of the urethra.Type: GrantFiled: July 12, 2012Date of Patent: March 31, 2015Assignee: AMS Research CorporationInventors: Sidney F. Hauschild, Stephen L. Bolea, Johann J. Neisz
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Patent number: 8968237Abstract: The present invention provides a method whereby a drug can be conveniently injected into the living body, without sticking a needle, from a device that is not in contact with the living body, and a device therefor. Specifically provided is a method for injecting a peptide drug such as insulin, and a device therefor. No special consumables are needed except the drug solution or suspension. The method and device comprise injecting a drug into the living body by electrospraying a solution or suspension of the drug from a nozzle to which high voltage is applied and which is not in contact with the living body.Type: GrantFiled: January 8, 2010Date of Patent: March 3, 2015Assignees: Mitsubishi Gas Chemical Company, Inc., Saitama UniversityInventors: Kazuto Ikemoto, Takafumi Sakai, Kanako Koike, Satoshi Sakahara
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Patent number: 8968236Abstract: An injection device (110) comprises a housing (112) adapted to receive a syringe (122) having a discharge nozzle (118), an actuator (114) and a drive (120) acted upon the syringe to advance it from a retracted position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle extends from the housing. There is a locking mechanism (HS) in communication with the actuator and activatable to be moved from a locked position in which the actuator is prevented from releasing the drive to an unlocked position in which the actuator is operable to act upon drive to advance the syringe. The locking mechanism or the housing includes integrally formed biasing means (210) adapted to return the locking mechanism to a locked position when it is not activated. There is no need for separate springs to be used bias to the releasable locking mechanism out the housing.Type: GrantFiled: March 21, 2006Date of Patent: March 3, 2015Assignee: Cilag GmbH InternationalInventors: Douglas Ivan Jennings, Charles Michael Dean
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Publication number: 20150051579Abstract: The present invention relates to medical devices, in particular autoinjectors and syringes having one or more thermochromic response indicators that are sensitive to temperature changes of a drug formulation or solution. The present invention provides for a pre-filled delivery device comprising a syringe, a cartridge, or a capsule having a barrel, where the barrel is marked on the outer surface with a first thermochromic indicator, and wherein the thermochromic indicator is responsive to temperature changes of the drug formulation or solution within the barrel.Type: ApplicationFiled: March 13, 2013Publication date: February 19, 2015Inventors: Jonathan Chung, Benjamin Bernstein, Paul Roussel
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Patent number: 8945045Abstract: A needleless fluid injection system include a working shaft (14) with a proximal end and a distal end, an injection shaft with a proximal end and a distal end, and a tissue tensioning mechanism (40) positioned at the distal end of at least one of the working shaft and the injection shaft. Embodiments of the tissue tensioning mechanism can include one or more of multiple radially expanding arcuate members (44), a linearly compressible element (60) with first and second plates at opposite ends of the linearly compressible element, an arcuate member (70) having a first end engaged within the lumen of the injection shaft and a second end moveable relative to the first end, first and second wedges (90a, b) that are slideable relative to each other, an inflatable bladder (110) with a foam material within a body opening of the bladder, at least two electromagnetic coils (146,148), or an electroactive polymer portion (166).Type: GrantFiled: July 20, 2010Date of Patent: February 3, 2015Assignee: AMS Research CorporationInventors: Jonathan J. Lund, Richard G. Rhode
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Publication number: 20150011966Abstract: Needleless injection device components, systems, and methods that involve features including an elongate shaft that has a working shaft comprising a working shaft proximal end, a working shaft distal end, and a working lumen extending between the working shaft proximal end and the working shaft distal end, an injection shaft including an injection shaft proximal end, an injection shaft distal end, and a needless injection orifice disposed through the sidewall at the injection shaft distal end, the injection shaft moveably disposed within the working lumen, and a tissue tensioner secured to the injection shaft at the injection shaft distal end and moveable relative to the working lumen, the tissue tensioner having an expandable surface capable of exhibiting an expanded state and a non-expanded state, the tissue tensioner in the expanded state being capable of tensioning luminal tissue for injection by the needless injection orifice.Type: ApplicationFiled: September 23, 2014Publication date: January 8, 2015Inventor: Justin M. Crank
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Publication number: 20150005735Abstract: A method and apparatus of applying a chemical treatment solution for effective castration of an animal through inducing cellular necrosis in or about the spermatic cord. The apparatus including a needlefree applicator head comprising a plurality of injector tubes for simultaneous treatment across a target areas. The target area being preferably clamped against the applicator head.Type: ApplicationFiled: January 7, 2013Publication date: January 1, 2015Inventor: Peter St Vincent Welch
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Patent number: 8920365Abstract: A sealing membrane 20 on a nozzle 10 for a jet injection device is adapted to seal off the nozzle orifice 12 by having a sealing rim 22 surrounding the nozzle orifice 12, which ensures a distinct closure of the nozzle orifice 12 to protect the nozzle geometry against damage and dirt and to protect the drug 30 contained in the cartridge 10 against contamination. The sealing rim 22 can narrowly enclose the nozzle orifice 12, or in case an adhesive 14 is applied to the nozzle face to ensure skin retention during injection, the sealing rim 22 can run in the middle of the adhesive covered area or entirely outside the adhesive covered area to protect the adhesive as well. A third sealing member 23 can also be provided to give a third distinct closure assurance in case the primary and secondary sealing membrane 20 is damaged. The third sealing member 23 can be one or more plug(s) adapted to press fit inside the nozzle orifice.Type: GrantFiled: January 19, 2007Date of Patent: December 30, 2014Assignee: Novo Nordisk A/SInventor: Jens Ulrik Poulsen
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Publication number: 20140371669Abstract: A needleless injector has a syringe body having an opening at one end, a piston housed within the syringe body for urging a liquid within the syringe body through the opening and a ram for driving the piston. A shock absorbing component is provided for reducing an initial transfer of force from the ram to the piston. The initial rate of pressure increase on the liquid is reduced, thereby controlling the rate of collapse of gas bubbles in the liquid.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Applicant: ZOGENIX, INC.Inventor: TERRY GREEN
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Publication number: 20140364829Abstract: A device and method for treating a tick bite or other skin wound that may have been exposed to pathogens employs a syringe filled with antipathogen solution whereby the solution is applied under mild pressure directly to the wound site. The device employs spreader/retractor arms to open the wound for better access of the solution into the wound. The method of using the device to cleanse and disinfect a wound is described.Type: ApplicationFiled: June 6, 2014Publication date: December 11, 2014Inventor: John Richard Parker
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Patent number: 8905966Abstract: The present invention relates to a novel type of a needle-free drug delivery system in which strong energy such as a laser beam is focused inside liquid contained in a sealed pressure chamber to cause bubble growth and the volume expansion in the sealed pressure chamber due to the bubble growth so as to elongate an elastic membrane, so that an instantaneous pressure is applied to a drug solution contained in a drug microchamber adjacent to the elastic membrane to allow the drug solution to be injected in the form of a liquid microjet, thereby enabling the drug solution to rapidly and accurately penetrate into the bodily tissues of the patient.Type: GrantFiled: July 28, 2010Date of Patent: December 9, 2014Assignee: SNU R & DB FoundationInventors: Jai-Ick Yoh, Tae-Hee Han
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Publication number: 20140358073Abstract: A piston for a needleless valve system comprising a head portion configured to be disposed in the needleless valve system and controlling fluid flow through the needleless valve system. The head portion comprising a continuous top surface, and an opening disposed proximate the continuous top surface, wherein the continuous top surface is non-planar when the opening is in an open position.Type: ApplicationFiled: August 12, 2014Publication date: December 4, 2014Inventors: Tyler Devin Panian, Jonathan Yeh
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Publication number: 20140336561Abstract: Embodiments disclosed herein are directed to systems and methods for protecting needleless injector units from one or more contaminants. In an embodiment, a needleless injector system includes a needleless injector unit and an auxiliary unit. The needleless injector unit has a nozzle portion and a supply of one or more substances for injection. The needleless injector unit is configured to inject the one or more substances from the nozzle portion through a skin surface of a subject. The auxiliary unit is coupleable to the needleless injector unit. The auxiliary unit includes a source of one or more protectants and is configured to emit the one or more protectants in a region between the nozzle portion of the needleless injector unit and the skin surface of the subject.Type: ApplicationFiled: May 8, 2013Publication date: November 13, 2014Applicant: Elwha LLCInventors: Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Lowell L. Wood, JR., Victoria Y.H. Wood
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Patent number: 8876759Abstract: An injection system (200) including an injection chamber (202) and an injectate reservoir (204) that is removably attached to the injection chamber via an intermediate connector (206). The connector extends at a first end from the chamber and terminates at an opposite end with a fitting, such as a luer fitting, to which the injectate reservoir can be attached. The connector can be a relatively flexible component, such as a flexible tube, which is capable of absorbing the energy of an impact or other manipulation of the system to prevent or minimize the possibility of premature disconnection of the reservoir from the system.Type: GrantFiled: December 4, 2009Date of Patent: November 4, 2014Assignee: AMS Research CorporationInventor: Justin M. Crank
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Patent number: 8876758Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.Type: GrantFiled: April 19, 2011Date of Patent: November 4, 2014Assignee: Zogenix, Inc.Inventors: Brooks M. Boyd, Sujata Mudumba, Stephen J. Farr
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Publication number: 20140308352Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: March 11, 2014Publication date: October 16, 2014Applicants: ZOGENIX INC., DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Patent number: 8852142Abstract: Described are needleless injection systems and methods that involve features including one or more of a tissue tensioner and a fitting for attaching to a distal end of a shaft, exemplary embodiments including: an elastic sleeve sized to fit under tension about the distal end of a flexible scope, such as an endoscope; a non-metal, polymeric tube-like device being optionally attached to the elastic sleeve for delivering a therapeutic fluid to a treatment site within a patient wherein the elastic sleeve may include an integral balloon (tissue tensioner) feature that can be used to position the injection orifice of the tube-like device proximate a treatment area.Type: GrantFiled: December 4, 2009Date of Patent: October 7, 2014Assignee: AMS Research CorporationInventor: Justin M. Crank
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Publication number: 20140296776Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.Type: ApplicationFiled: March 26, 2014Publication date: October 2, 2014Applicant: ZOGENIX, INC.Inventors: GREGOR JOHN McLENNAN ANDERSON, JOHN MITCHELL
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Publication number: 20140276535Abstract: A needleless injector includes an injector body, a nozzle at one end of the body, a medicine inlet for receiving medicine into the injector body, a rod disposed within the injector body for driving the medicine towards the nozzle, and a sensor for monitoring operation of the needleless injector. The sensor may be a position sensor. The sensor may be a slide potentiometer. The sensor may provide for monitoring firing of the rod and/or monitoring length of a stroke of the rod. An intelligent control operatively may be operatively connected to the sensor. An RFID reader may also be operatively connected to the intelligent control for associating RFID data with operations of the needleless injector. A keypad may be operatively connected to the intelligent control and a display may be operatively connected to the intelligent control.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventors: Michael Wood, Chris Vanden Berghe
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Publication number: 20140249471Abstract: A cylinder-piston unit, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. On its end face directed away from the bottom portion, the adhesive disc has an adhesive coating. In the storage position, the adhesive disc has at least one sealing element or a sealing area for closing the discharge tube, the effect of which sealing element or sealing area is no longer present in the application position. In the application position, the front edge of the end face of the discharge tube protrudes at least 0.5 mm beyond the adhesive coating of the adhesive disc.Type: ApplicationFiled: May 13, 2014Publication date: September 4, 2014Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventor: RUDOLF MATUSCH
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Publication number: 20140249470Abstract: A cylinder-piston unit, of a needle-free injector, with at least one cylinder accommodating an injection solution, and with at least one piston. The piston is composed of a drive body and of a sealing body. The sealing body is at least one elastic disc, which bears under a radial clamping action against the inner wall of the cylinder. The drive body is a pot-shaped body with a peripheral elastic skirt. At least one area of the skirt bears under a radial clamping action against the inner wall of the cylinder. The cylinder chamber areas located in front of and behind the drive body communicate with each other via at least one recess. The drive body is arranged behind the sealing body in the cylinder, and the skirt faces towards the sealing body.Type: ApplicationFiled: May 13, 2014Publication date: September 4, 2014Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventor: RUDOLF MATUSCH
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Patent number: 8821434Abstract: A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.Type: GrantFiled: October 7, 2011Date of Patent: September 2, 2014Assignee: Massachusetts Institute Of TechnologyInventors: Ian W. Hunter, Andrew J. Taberner, N. Catherine Hogan