Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

Abstract: A disposable nozzle for use on the discharge end of the barrel of a needleless injector is threaded onto the front end of a holder mounted in the barrel. A resilient detent extending outwardly at an acute angle from the inner wall of a recess in the rear end of the nozzle repeatedly enters and exits notches in a sleeve on the holder when the nozzle is mounted on the holder providing an audible signal that the nozzle has not been used. Reverse rotation of the nozzle during removal from the holder results in breaking of the detent. Thus, mounting of a used nozzle on the holder would not be accompanied by a signal that the nozzle is unused.

Abstract: The invention relates to an attachment (10) for a standard injection device (70) for needleless injection of a fluid, having a nozzle adapter (12) and a piston unit (40), wherein the nozzle adapter (12) comprises a skin contact surface (16) arranged on the distal end (14) thereof having an outlet opening (18), a first cylinder section (20) connecting proximally to the outlet opening (18) and a second cylinder section (26) connecting to the first cylinder section (20), and the piston unit (40) is mounted in a movable manner in the first cylinder section (20) to form a piston-cylinder unit and the attachment (10) has a fluid line (48) for transporting fluid from the standard injection device (70) to the outlet opening (18).

Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.

Abstract: The present invention provides a needle-free injector for delivering a medicament under pressure into an animal or human, the injector having a charging mechanism comprising a threaded shaft/nut member combination. The injection device is of the type that includes an actuating device comprising: a gas tight chamber; a piston and rod assembly slidably received in the chamber and movable between a forward position and a rearward position; a gas charge in the chamber for urging the piston and rod assembly to the forward position; a mechanism for moving said piston and rod assembly against said gas charge into the rearward position; and a trigger for releasably retaining the piston and rod assembly in the rearward position. Also provided is a method and kit for using the device including the charging mechanism to administer a liquid through the skin of an animal or human.

Abstract: The invention refers to an interlock mechanism for restricting a rotational movement of a rotatable component (1) of a drug delivery device (10) and to a method for controlling the rotational movement of the rotatable component (1).

Abstract: A housing of the injector is made from a thin-walled sheet-metal part. The sheet-metal part has at least two branches or legs. Each branch has, at the free end thereof, an angled retaining element or a recess as a means of receiving the cylinder of a cylinder/piston unit. The branches are elastic flexural beams which, in the middle area, are each bent in a Z-shape or S-shape to form a supporting portion for the piston-actuating ram. The contact zone situated between an individual supporting portion and the piston-actuating ram represents a wedge gear pairing that forces the respective branch outwards. The trigger unit comprises at least a trigger element which is slidably supported on the metal sheet, wherein the support section or, respectively the contact sections extend outwardly into longitudinal grooves. The branches may be provided with a locking tongue to engage corresponding openings in the trigger element to lock the housing in position as desired.

Abstract: Drug delivery devices adapted to receive liquid medication vials to fill a reservoir, utilize sliding through valves that are closed except when driven by force of liquid medication pushed by a plunger to an open position to feed the medication via needle to a patient or via a connection to an IV port. The devices have multiple seals and automatically close up when pressure on the plunger is released. The methodology is also included.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least cylinder/piston unit (100) filled with an injection solution, at least one piston-actuating ram, and at least one trigger unit. The spring-loaded piston-actuating ram is supported on the housing via at least one support rod (21), wherein the contact zone located between an individual support rod and the piston-actuating ram represents a wedge gear pairing that forces the respective support rod radially outwards. The support rod or support rods bear on at least one activation element (82) that is mounted on the housing and positioned in a locking position. The activation element can be brought by displacement into a triggering position that releases the piston-actuating ram.

Abstract: Embodiments herein relate to the field of injections, for instance needle-free injections, and more specifically, to methods and apparatus for spring-driven intramuscular and intradermal injections. Provided in some embodiments are needle-free injectors adapted to deliver intradermal injections, as well as vial adaptors that are adapted to function as spacers when used with a needle-free injection device.

Abstract: The present invention relates to an injection device comprising a housing, a resilient member adapted to provide a force in the axial direction of the injection device for ejecting a dose from the injection device. The injection device further comprises a dose setting member operatively connected to a dose indicator barrel positioned within the housing, the dose setting member and the dose indicator barrel being movable relative to each other and cooperating to set the dose to be ejected from the injection device. The dose indicator barrel undergoes, during dose setting, a combined rotational and translational movement within the housing and relative to the housing.

Abstract: A disposable injector with a housing that has at least one compression hook, which has at least one support surface respectively in the region of its free end. A piston-actuating plunger rests on the support surface. The locking position of the compression hook is secured by an actuating element positioned in a locked position. The actuating element has a locked position, in which it rests securely on a sealing cap. The actuating element has a triggering position, which effects lateral retreat of the compression hook when the piston-actuating plunger is released.

Abstract: A disposable injector with a housing (10) in which at least one mechanical spring energy accumulator (50), at least one cylinder-piston unit (100), at least one piston-actuating ram and at least one release unit are arranged. The housing has at least one draw hook (21) which has at least one supporting surface in the region of its free end. The piston-actuating ram bears against the supporting surface. The blocking position of the draw hook is ensured by a release element positioned in a blocking position. The release (82) has a release position which brings about an inevitable lateral retraction of the draw hook—with the piston-actuating ram being released.

Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

Abstract: The invention provides for a needle-free or needle-less intradermal injection device that is capable of delivering an agent of interest to only the intradermal space. The intradermal device can deliver lower volumes of an agent than commonly used with present devices. In one aspect of the invention, the intradermal device is useful for delivering one or more agents to the intradermal space for eliciting immune responses particular to the dermal layer. In other aspects of the invention, the intradermal device is useful for delivering one or more agents to the intradermal space for treating, delaying development of delaying the progression of preventing, and/or ameliorating symptoms of various diseases, disease states, and conditions.

Abstract: A kit of parts for use in the manufacture of a particle cassette for a needleless syringe device. The kit may include a first cassette part having a first rupturable membrane sealed thereto and a second cassette part having a second rupturable membrane sealed thereto. The first and second cassette parts may be arranged to be attachable together so as to create a chamber for the confinement of particles between the first and second membranes. The first and second cassette parts may be substantially annular and the first cassette part defines a receptacle for receiving particles. The second cassette part may be attachable concentrically around or inside the first cassette part.

Abstract: An injection device (110) is provided that includes a housing (112) and a drive (121) that acts upon a syringe (122) when released by a trigger (114). The trigger (114) is rotatable from a rest position, in which it causes the drive (121) to be retained, to an active position, in which it no longer causes the drive (121) to be retained. A damping means (132) is arranged in conjunction with the trigger (114) to prevent accidental actuation of the device (110). Such an injection device (110) provides improved reliability and resilience to damage caused by impact forces, for example, when the device (110) is dropped onto a hard surface. The trigger (114) is also retained in its active position after actuation, indicating that the device (110) has been used. Additionally, the noise production by the operation of the trigger (114), which may be distressing to a user, is reduced.

Abstract: A transdermal drug delivery system (100) for providing controlled doses of a drug through the skin of a human or other animal is disclosed. In one embodiment, the transdermal drug delivery system (100) includes a substrate (110) designed to adhere to skin and a transdermal injector array (140) coupled to the substrate (110). The transdermal array (140) has one or more transdermal injectors (210, 220, 230) embedded within including a first transdermal injector (210) configured to administer or provide a first substance to the skin at a speed great enough to produce an appreciable breach in the surface of the skin.

Abstract: In one aspect of this invention, control systems (100) are provided for controlling the inflation of a tissue tensioner or balloon for a fluid delivery system, such as for a needleless fluid injection device. In another aspect of the invention, a system for reducing the response time for jet injection of fluid is provided (200). In yet another aspect of the invention, systems and devices are provided for controlling the volume of fluid that is ejected from a fluid injection system, which systems include at least one stop (410) that is selectively rotated to limit the movement of a shaft (402) in a linear direction, thereby controlling the amount of fluid that is ejected from the system.

Abstract: The present invention relates to stable compositions of anti-NGF antibodies, and antigen-binding fragments thereof, and their uses in the prevention and/or treatment of various diseases and disorders in which NGF activity is detrimental, e.g., pain disorders.

Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a delivery nozzle end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the delivery nozzle end of the elongated agent delivery member with a delivery pressure in the range of approximately 50-1000 psi.

Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a second ejection end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the ejection end of the elongated agent delivery member. In one embodiment of the invention, the delivery-member comprises a needleless delivery member.

Abstract: A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-locked piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector is compact and has few components, is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-loaded piston-actuating ram being supported on the housing via support rods (240) or draw hooks (250) and each contact zone between an individual support rod or draw hook and the piston-actuating ram representing a wedge gear pairing that forces the respective support rod or draw hook radially outwards. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part has at least two limbs (220, 250) arranged parallel to each other. The sheet metal part has at least two pressure bars or at least two draw hooks the free ends of which are bent in an angular fashion to define a supporting section for the piston-actuating ram.

Abstract: An injection device (110) comprises a housing (112) adapted to receive a syringe (122) having a discharge nozzle (118), an actuator (114) and a drive (120) acted upon the syringe to advance it from a retracted position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle extends from the housing. There is a locking mechanism (HS) in communication with the actuator and activatable to be moved from a locked position in which the actuator is prevented from releasing the drive to an unlocked position in which the actuator is operable to act upon drive to advance the syringe. The locking mechanism or the housing includes integrally formed biasing means (210) adapted to return the locking mechanism to a locked position when it is not activated. There is no need for separate springs to be used bias to the releasable locking mechanism out the housing.

Abstract: An injection system (200) including an injection chamber (202) and an injectate reservoir (204) that is removably attached to the injection chamber via an intermediate connector (206). The connector extends at a first end from the chamber and terminates at an opposite end with a fitting, such as a luer fitting, to which the injectate reservoir can be attached. The connector can be a relatively flexible component, such as a flexible tube, which is capable of absorbing the energy of an impact or other manipulation of the system to prevent or minimize the possibility of premature disconnection of the reservoir from the system.

Abstract: Described are needleless injection systems (100) and methods that involve features including one or more of a tissue tensioner (114) and a fitting (111) for attaching to a distal end of a shaft, exemplary embodiments including: an elastic sleeve (10) sized to fit under tension about the distal end of a flexible scope, such as an endoscope; a non-metal, polymeric tube-like device being optionally attached to the elastic sleeve for delivering a therapeutic fluid to a treatment site within a patient wherein the elastic sleeve may include an integral balloon (tissue tensioner) feature that can be used to position the injection orifice of the tube-like device proximate a treatment area.

Abstract: Dosage form of aliskiren, comprising a device for transdermal administration of aliskiren and aliskiren (including salts, prodrugs and metabolites thereof), optionally together with pharmaceutically acceptable carrier(s) to a human being or an animal in order to achieve a desired therapeutic effect. Use of a compound comprising aliskiren, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable carrier(s), for the manufacture of a composition to be administered transdermally for achieving a desired therapeutic effect. Method for achieving a desired therapeutic effect by transdermal administration of a compound comprising aliskiren, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable carrier(s).

Abstract: The invention relates to needle-free apparatus that can be used to augment soft tissue. More specifically, the needle-free injectors of the present invention allow injection of more viscous materials such as collagen, hyaluronic acid, and other polymers that are useful as dermal fillers. The needle-free injectors of the present invention allow injection of such materials to fill the undesired lines, wrinkles, and folds of a patient. The present invention also relates to kits comprising such needle-free injectors and a quantity of dermal filling material. In addition, the present invention relates to methods of augmenting soft tissue using needle-free apparatus.

Abstract: The invention relates to a system for injecting a fluid through or into the human skin, optionally by needle-free injection or by injection with a needle, with (i) an injection device (110) which includes an ampoule (112) with an ampoule body (114) forming a chamber for receiving the fluid to be injected; an ampoule piston (118) which is axially movable and sealingly guided in the chamber; an outlet (124) disposed at the distant end of the ampoule (112) for the fluid to be injected, wherein the ampoule (112) is rounded in the region of the outlet (124) and the rounded region forms a skin contact surface (126) for the needle-less injection through or into the human skin; and at least one first coupling element (128) of a coupling device which is arranged at the distal end of the ampoule (112) on the ampoule body (114) and configured for sealingly and reversibly attaching a needle attachment (150), and (ii) a needle attachment (150) with a cannula part (152) comprising a needle (156); and an adapter part

Abstract: The invention relates to a needle-less, disposable injector comprising a housing (10), which has at least one compression bar, a cylinder-piston unit (100), a plunger-actuating ram (60), a trigger unit (80) and a spring energy reservoir (50), wherein the trigger unit locks the pre-tensioned spring energy reservoir by means of the compression bar. During triggering, the compression bar slides along at least one trigger element (82) of the trigger unit and, after triggering the trigger unit, the spring energy reservoir displaces the compression bar by means of the plunger-actuating ram and actuates the cylinder-piston unit. When loaded by the pre-tensioned spring energy reservoir, the pairing formed by the mutually facing inner wall of the trigger element and the contact surface of the compression bar has at least in areas a higher sliding friction coefficient than the pairing formed by the mutually facing collar surface of the plunger-actuating ram and the support surface of the compression bar.

Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.

Abstract: A high-pressure fluid injection system, which includes a rechargeable injection chamber with a proximal end, a distal end, and an internal opening extending from the proximal end to the distal end, a plunger slideably engaged with the internal opening of the injection chamber, an injection tube extending from the distal end of the injection chamber and in fluidic communication with the internal opening of the injection chamber, and a check valve between the proximal and distal ends of the injection chamber. The internal opening includes a high-pressure zone adjacent to the check valve and having a first diameter, and a low-pressure zone proximal to the high-pressure zone and having a second diameter that is larger than the first diameter.

Abstract: A device for administering a fluid product, the device including a first housing part provided with a receiver for the product, a second housing part detachably connectable to the first housing part, a piston rod held such that it can be displaced for the exertion of an emptying movement, an actuatable or releasable drive element for the piston rod, a coupling element including a coupling input element that couples the drive element to the piston rod in a coupling engagement, transmits a driving force of the drive element to the piston rod, and triggers the emptying movement, and a decoupling element displaceably connected to the second housing part and coupled to the first housing part such that it is displaced, by a movement of the housing parts in relation to each other when the housing parts are separated into a decoupling position wherein the piston rod is decoupled from the coupling input element.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: The invention relates to a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered. The present invention develops a disposable injector which stores a liquid and an active ingredient in each case separately and sterilely and provides a space in which the active ingredient is dissolved for application in the liquid or mixed with the liquid.

Abstract: The present invention relates to a syringe (20) defining a reservoir (21) for containing a liquid and comprising an end-piece (10) encompassing a channel (11) providing a passageway for the transfer of the said liquid, characterized in that the said channel (11) comprises two portions, a first portion (12) and a second portion (13), the said first portion (12) extending from the free distal end (14) of the end-piece (10) in the direction of the reservoir (21), and the said second portion (12) extending between the first portion (12) of the channel (11) and the proximal end (15) of the end-piece (10) and connecting the said first portion (12) to the reservoir, the said first portion (12) having an average diameter that is greater than the average diameter of the said second portion (13).

Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.

Abstract: Needle-free injection devices having a drive assembly to provide an operative force to effect an injection and a dosing assembly to prepare the device for a subsequent injection. In some embodiments, the dosing assembly is configured to transfer injectate from an injectate source to the injectate assembly. In some embodiments, a portion of energy available to the drive assembly urges the injectate towards the injectate assembly. In some embodiments, the device includes a nozzle assembly having one or more ports.

Abstract: A medication delivery apparatus for use with a medication container includes a housing, a fluid conduit at least partially extending within the housing and configured to deliver medication within the medication container to a patient, a medication port extending from the housing and configured to be coupled to a fluid outlet of the medication container, the medication port being fluidically coupled to the fluid conduit, and at least one sensor disposed within the housing to generate information characterizing administration of the medication for processing by a remote data collection system. The housing can have a size and shape that enables it to be supported by a first hand of a user while the user administers the medication from the medication container via the medication port using a second hand of the user. Related apparatus, systems, and techniques are also described.

Abstract: A medication injection site is provided that includes a medication port and an identification sensor. The medication injection site, when coupled to a medication container, can wirelessly transmit data characterizing the contents of the medication container to a remote data collection system. The housing of the medication injection site has a shape and size enabling it to be held by a first hand of a user while the user administers medication from the medication container via the medication port using his or her second hand. In some implementations, the medication injection site can be placed on an IV drip line. Related apparatus, systems, and kits are also disclosed.

Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.

Abstract: Compositions of proteins having free thiols, and methods of making and using such compositions, are described.

Abstract: A device configured for drug delivery through the skin of a subject, the device comprising a substrate, a proximal side of which is positioned toward the skin of the subject during use; at least one fluid receptacle positioned on the substrate and containing a store of the drug; at least one ejection chamber positioned on the proximal side of the substrate; at least one fluid via fluidly connecting the at least one fluid receptacle with the at least one ejection chamber; a heating element positioned adjacent at least a portion of the at least one ejection chamber, said heating element configured to rapidly heat and vaporize the fluid along that portion of the ejection chamber, causing ejection of fluid therefrom; and logic, wherein the logic is programmable to initiate heating by the heating element.

Abstract: A spike for penetrating the elastomeric stopper of a container, for example a drug or reagent vial, is provided with an elongated body (5) with a blunt tip (47). The spike may be incorporated into a reagent cassette which accepts containers sealed with a punturable cap.

Abstract: The invention provides a silencer and silencing method which ensures adequate silencing with no deleterious increase in back pressure (which creates a lift-off force) or decrease in device performance. Pressurized gas is supplied to a driver chamber by a bleed-hole having an effective bleed-hole area and, during use of the device for particle delivery, gas is vented to the atmosphere via a silencer having an effective venting area. The bleed-hole area and venting area are chosen to ensure that the mass flow rate of gas through the effective venting area is substantially equal to or greater than the mass flow rate of gas through the effective bleed-hole area. This ensures that there is no build up of gas in the silencer device which tends to increase back pressure and hence lift-off force. Preferred embodiments of the device comprise a silencer having a large volume and a small particle exit opening. Further, there is disclosed an embodiment using one or more transfer ducts to assist particle mixing.

Abstract: The invention relates to a device for needleless transdermal drug delivery. The device according to the invention comprises an actuator (104) and a support (102) which has a support stiffness. The actuator (104) has a driver part (108) and a support part (106), which support part (106) is connected to the support and which driver part (108) is displaceable with regard to the support part (106) along an axis of displacement (110). The device according to the invention is characterized in that the support stiffness provides a substantially zero displacement of the actuator's support part (106) along the driver's axis of displacement (110) during a displacement of the driver part (108) along said axis with regard to the support part (106).

Abstract: A gas-powered, single-use, needle-less hypodermic jet injection device includes a hand-held injector, and a drug injection cartridge which provides a cylinder of liquid medication to be injected, an injection orifice, and an injection piston. Forceful movement of the injection piston in the cylinder causes an injection jet of medication to be expelled from the injection orifice. The injection device also includes a hermetically sealed gas pressure capsule which remains sealed until the moment of injection and powers the jet injection after opening of this cartridge.