Needleless Hypodermic Injector Patents (Class 604/68)
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Publication number: 20140243740Abstract: A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the centre line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm.Type: ApplicationFiled: May 13, 2014Publication date: August 28, 2014Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventor: RUDOLF MATUSCH
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Publication number: 20140236117Abstract: The present invention is directed to a patient interface for use with an injector assembly, the patient interface having a removable cap, wherein removal of the cap after an injection disables the patient interface to prevent re-use.Type: ApplicationFiled: February 20, 2013Publication date: August 21, 2014Applicant: Pulse Needlefree Systems, Inc.Inventor: MICHAEL DUTCHER
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Publication number: 20140221915Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: ApplicationFiled: April 14, 2014Publication date: August 7, 2014Applicant: ZOGENIX, INC.Inventors: BROOKS M. BOYD, JEFFREY A. SCHUSTER
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Patent number: 8793075Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: July 29, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Publication number: 20140207047Abstract: A bioactive agent delivery device having a plurality of reservoirs wherein each reservoir houses a solvent provides a means for separable and segregated delivery of bioactive agent(s) to a patient. The device can include a plurality of absorbent materials wherein each absorbent material is pretreated with a bioactive agent and a delivery mechanism operable to deliver to any of the plurality of absorbent materials a controlled portion of solvent from any of a plurality of reservoirs. A diffusion layer interposed between the absorbent materials and an epidermis transfers the bioactive agent from the absorbent materials to the epidermis for delivery of the bioactive agent.Type: ApplicationFiled: January 16, 2014Publication date: July 24, 2014Applicant: Chrono Therapeutics, Inc.Inventors: Guy DiPierro, Michael Barsness, Bireswar Chakroborty, Kuowei Chang
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Patent number: 8740838Abstract: A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.Type: GrantFiled: October 7, 2011Date of Patent: June 3, 2014Assignee: Massachusetts Institute of TechnologyInventors: Brian D. Hemond, Ian W. Hunter, Andrew J. Taberner, Dawn M. Wendell, N. Catherine Hogan
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Publication number: 20140142500Abstract: A drug capsule and a method for making a drug capsule for a drug delivery device, such as an auto injector or needle-free injector, with improved stability and container closure integrity. The injector comprises a drug capsule sealed by a piston fabricated from PTFE modified by the inclusion of a co-polymer of PPVE, preferably in an amount less than 1% by weight, resulting in better performance while the device is stored and subjected to temperature cycling.Type: ApplicationFiled: April 22, 2013Publication date: May 22, 2014Inventor: ZOGENIX, INC.
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Patent number: 8731841Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: May 20, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 8731840Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: May 20, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 8731842Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: March 31, 2009Date of Patent: May 20, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 8721583Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: May 13, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Patent number: 8725420Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.Type: GrantFiled: October 31, 2008Date of Patent: May 13, 2014Assignee: The Invention Science Fund I, LLCInventors: Edward S. Boyden, Daniel B. Cook, Roderick A. Hyde, Eric C. Leuthardt, Nathan P. Myhrvold, Elizabeth A. Sweeney, Lowell L. Wood, Jr.
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Publication number: 20140128805Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicant: AMS Research CorporationInventors: Justin M. Crank, Suranjan Roychowdhury, Carey J. Becker
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Patent number: 8715259Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively movable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.Type: GrantFiled: September 12, 2012Date of Patent: May 6, 2014Assignee: Zogenix, Inc.Inventors: Gregor John McLennan Anderson, John Mitchell
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Patent number: 8708951Abstract: The invention relates to a single-use injector (4) and a dual-chamber system (99), wherein at least one first chamber (105) is part of a cylinder-piston unit (100) that can be received in the single-use injector, and wherein the second chamber (255) is part of a container (250) that can be at least temporarily closed by means of a stopper (257) and that is inserted in a container adapter (200) releaseably supported on the single-use injector. To this end, the plug comprises a plug hole. The container adapter comprises a transfer tube that is closed at first. When the container is inserted in the container adapter, the transfer tube (242) connects the interior of the cylinder-piston unit to the interior of the container.Type: GrantFiled: February 22, 2011Date of Patent: April 29, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventor: Rudolf Matusch
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Publication number: 20140107568Abstract: The present disclosure relates to methods of determining dosages of compositions used in injection devices, in view of known oral doses of the same compositions.Type: ApplicationFiled: November 14, 2012Publication date: April 17, 2014Inventors: Peter L. Sadowski, Kaushik J. Dave, Paul K. Wotton, Hermanus LeRoux Jooste
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Patent number: 8696553Abstract: An automatic retractable syringe includes a tubular body on which a syringe opening is provided; a piston body in whose pressing portion a vent hole VA is formed and in whose shaft portion a vent passage passing from the vent hole VA through inside to the front end portion is formed; and a spring which returns the pressed piston body to its original position. When the pressing portion is pressed by a thumb or other finger plugging the vent hole VA to move the piston body forward, air is supplied from the syringe opening. Subsequently, when the thumb or other finger is released, air flows into the tubular body through the vent hole VA and the vent passage, and the piston body automatically returns to its original position by the spring. Therefore, air can be consecutively supplied by repeatedly pressing the pressing portion.Type: GrantFiled: February 17, 2009Date of Patent: April 15, 2014Assignee: FUJIFILM CorporationInventor: Kenji Yamane
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Patent number: 8663158Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.Type: GrantFiled: April 18, 2013Date of Patent: March 4, 2014Assignee: Zogenix, Inc.Inventors: William Henry, Andrew Lewis
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Patent number: 8652094Abstract: The present invention relates to a syringe (20) defining a reservoir (21) for containing a liquid and comprising an end-piece (10) encompassing a channel (11) providing a passageway for the transfer of the said liquid, characterized in that the said channel (11) comprises two portions, a first portion (12) and a second portion (13), the said first portion (12) extending from the free distal end (14) of the end-piece (10) in the direction of the reservoir (21), and the said second portion (12) extending between the first portion (12) of the channel (11) and the proximal end (15) of the end-piece (10) and connecting the said first portion (12) to the reservoir, the said first portion (12) having an average diameter that is greater than the average diameter of the said second portion (13).Type: GrantFiled: May 27, 2009Date of Patent: February 18, 2014Assignee: Becton Dickinson FranceInventors: Olivier David, Emeric Mermet
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Patent number: 8652095Abstract: A skin retention device 10 for a medical jet-injection unit 20 having a contact face provided with adhesive 12 in the area surrounding and close to the injection opening(s) 11 of the nozzle 21 which ensures good contact between the nozzle 21 and the skin 30 of a subject in the area chosen for an injection. The injection force can be lowered dramatically. In case of two-stage jet-injections, the initial injection force can be lowered because the skin retention close to the injection point significantly reduces the energy consuming elastic expansion of the skin 30 in the injection area, and the second injection force can be lowered because of the high degree of fixed positioning of the injection opening of the nozzle 21 relative to the injection channel in the skin 30 made during the initial injection stage.Type: GrantFiled: July 12, 2011Date of Patent: February 18, 2014Assignee: Novo Nordisk A/SInventors: Torben Stroem Hansen, Jens Erik Poulsen
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Patent number: 8641668Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least one cylinder/piston unit (100), at least one piston-actuating ram, and at least one trigger unit. For this purpose, the housing has at least one inverted draw hook, which has at least one support surface respectively in the region of its free end. The spring-loaded piston-actuating plunger rests on the support surface, whereby the contact zone placed between the draw hook and the piston-actuating plunger represents a variable-speed gear pair thrusting the draw hook radially outwards. The locking position of the draw hook is secured by an actuating element positioned in a locked position. The actuating element has a triggering position which effects radially outwards aligned retreat of the draw hook when the piston-actuating plunger is released.Type: GrantFiled: December 14, 2009Date of Patent: February 4, 2014Assignee: LTS Lohmann Therapie-Systeme AGInventor: Rudolf Matusch
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Patent number: 8636688Abstract: This invention relates to medical devices useful for infusion therapy and, more particularly, to a syringe that can be selectively used with a retractable needle or with frontal attachment devices such as luer hubs, valves or other connectors in needleless systems.Type: GrantFiled: September 11, 2012Date of Patent: January 28, 2014Assignee: Retractable Technologies, Inc.Inventor: Thomas J. Shaw
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Patent number: 8636704Abstract: Exemplary embodiments provide a syringe plunger formed of a polymeric material. The syringe plunger includes a pressurizer disposed at a proximal end, and a distal end bifurcated into a first plunger arm having a first conical surface and a second conical surface, and a second plunger arm having a first conical surface and a second conical surface. The distal end includes a first contact surface defined by the first conical surface of the first plunger arm and the first conical surface of the second plunger arm, the first contact surface configured to initially contact a firing engagement mechanism, the first contact surface disposed at a first angle of between about 40° and about 80° relative to a longitudinal axis of the syringe plunger.Type: GrantFiled: April 29, 2010Date of Patent: January 28, 2014Assignee: AbbVie Biotechnology LtdInventors: Sherwin S. Shang, Esra Ozdaryal, Marc M. Plew, William P. Szechinski
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Publication number: 20140023985Abstract: A needleless injector syringe includes a tubular barrel containing a first chamber for receiving a liquid, a nozzle on a front end of the barrel, a piston which drives a plunger for discharging the liquid through the nozzle, a second chamber in which the piston slides, a third chamber in fluid communication with the second chamber for receiving gas from said second chamber during forward movement of the piston, and for carrying gas to the second chamber to cause the piston to retract, and a breach plug closing a rear end of the barrel for directing gas under pressure alternately against the rear end of the piston and to the third chamber for driving the piston between the discharge position and a retracted position.Type: ApplicationFiled: April 3, 2012Publication date: January 23, 2014Inventors: Karim Menassa, Maurice Menassa, Adam Gadoua
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Patent number: 8632508Abstract: A pressurized injection device comprises a mechanical loading mechanism comprising a double set of rackets (17,18) and ball bearings/pins running in a curved track (20) which enables a resilient element (7) to be pre-stressed by—twisting the two outer house parts of the device relative to each other back and forth. When twisted in one direction one set of rackets (17) engages the teeth of the piston rod (9) connected to the resilient element and when twisted in the opposite direction, the other set of rackets (18) engages same piston rod. The resilient element is set off to engage a plunger of a container holding a drug to be injected by pressing the release button (1), which can be secured by a safety switch.Type: GrantFiled: May 7, 2007Date of Patent: January 21, 2014Assignee: Novo Nordisk A/SInventors: Torben Stroem Hansen, Matias Melander
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Publication number: 20140018731Abstract: A disposable syringe for use in a needleless injector includes a tubular body with an open rear end, a closed front end containing an injection orifice, a chamber in the body for receiving a liquid and a plunger slidable in the chamber for pushing the liquid out of the orifice. A tip is provided on the inner end of the plunger for separation from the remainder of the plunger to block the orifice when the plunger is retracted after an injection, whereby the syringe cannot be re-used.Type: ApplicationFiled: April 3, 2012Publication date: January 16, 2014Inventor: Karim Menassa
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Patent number: 8628494Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.Type: GrantFiled: July 20, 2010Date of Patent: January 14, 2014Assignee: AMS Research CorporationInventors: Justin M. Crank, Suranjan Roychowdhury, Carey J. Becker
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Publication number: 20140005637Abstract: A minimally invasive fat cell removal system and method is provided using a numbing component, a laser component, and a NIL component. A cannula and fiber of the laser component are insertable into a body of a patient at a biopsy punch to liquefy a fat cell via a tumescent fluid and/or a laser. A NIL cannula of the NIL component is insertable into the body to remove the fat cell via suction and/or nutation. An anesthetic device of the numbing component may reduce sensation of the body where the cannula is insertable. The fat cell may be harvested and implanted at another location of the body.Type: ApplicationFiled: June 24, 2013Publication date: January 2, 2014Inventor: Aaron J. Rollins
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Patent number: 8617099Abstract: A nozzle assembly for a needle-free injection device. The nozzle assembly includes a nozzle body including an injectate chamber and one or more outlet orifices and a plunger configured to move through the injectate chamber toward the one or more outlet orifices. In some embodiments, the plunger includes a first portion and a second portion removably joined by a frangible region. In some embodiments, the plunger includes extensions configured to couple the plunger to a drive assembly of a needle-free injection device.Type: GrantFiled: November 30, 2009Date of Patent: December 31, 2013Assignee: Bioject Inc.Inventor: Daniel E. Williamson
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Publication number: 20130338578Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.Type: ApplicationFiled: April 18, 2013Publication date: December 19, 2013Inventor: ZOGENIX, INC.
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Publication number: 20130338579Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.Type: ApplicationFiled: August 22, 2013Publication date: December 19, 2013Inventors: Nigel R. BATES, Philip T. PRICE
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Patent number: 8597233Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.Type: GrantFiled: November 25, 2011Date of Patent: December 3, 2013Assignee: LTS Lohmann Therapie—Systeme AGInventor: Rudolf Matusch
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Patent number: 8574188Abstract: The invention relates to a novel drug delivery technology. More particularly the invention relates to a method of delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient; to a throwaway or reusable device for delivering at least one therapeutic compound or a formulation comprising the at least one therapeutic compound to a patient in a manner as set out by the method; to a pioneer projectile for use in said method; to formulations for use in said method and to an injectate comprising a pioneer projectile and formulation. It also relates to a disposable component containing either a pioneer projectile or an injectate. The invention also relates to a throwaway or reusable device for delivering at least one therapeutic compound, or a formulation comprising the at least one therapeutic compound (hereafter drug) to a patient, and a method for administering a drug to a patient using said device.Type: GrantFiled: August 25, 2011Date of Patent: November 5, 2013Assignee: Glide Pharmaceutical Technologies LimitedInventors: David Stuart Potter, Charles David Ogilvy Potter
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Patent number: 8574217Abstract: An agent delivery apparatus for administering a pharmacological agent formulation to a sub-mucosal compartment of a body organ, comprising injector means having an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein and an elongated agent delivery member having a first end that is in communication with the internal formulation chamber and a delivery nozzle end, the injector means including force generating means that is adapted to generate sufficient force to expel the pharmacological agent formulation from the injector means and into and through the agent delivery member, and out of the delivery nozzle end of the elongated agent delivery member with a delivery pressure in the range of approximately 50-1000 psi.Type: GrantFiled: February 10, 2011Date of Patent: November 5, 2013Assignee: KMG Pharma, LLCInventor: Gholam A. Peyman
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Patent number: 8540665Abstract: An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.Type: GrantFiled: November 4, 2009Date of Patent: September 24, 2013Assignee: Powder Pharmaceuticals Inc.Inventors: Nigel Robert Bates, Philip Thomas Price
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Patent number: 8535263Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-locked piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector is compact and has few components, is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.Type: GrantFiled: June 15, 2011Date of Patent: September 17, 2013Assignee: LTS Lohmann Therapie-Systeme AGInventor: Rudolf Matusch
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Patent number: 8529500Abstract: A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human.Type: GrantFiled: June 16, 2011Date of Patent: September 10, 2013Assignee: PharmaJet, Inc.Inventors: John Bingham, Robert Steinway
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Patent number: 8529499Abstract: A disposable injector having a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least one cylinder-piston unit (100) that can be filled at least in part with an active substance, at least one piston actuation plunger (60) and at least one trigger unit (80). The spring energy accumulator plunger (60) has at least one tension bar (61) with at least one support surface (63) at the upper end thereof. Locking elements (16) supported on the housing lie on the support surface(s) and are secured in the locking position by a triggering element (82) placed in a locking position (8). The triggering element has a release position (9) that causes the locking element (16) to be unlocked for release of the active substance.Type: GrantFiled: July 17, 2009Date of Patent: September 10, 2013Assignee: LTS Lohmann Therapie-Systeme AGInventor: Rudolf Matusch
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Publication number: 20130231311Abstract: Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting, which include sustained release formulations, and combination products. Also included are treatments for multiple symptoms of migraine, especially headache and nausea and vomiting. Systems that are self contained, portable, prefilled, and simple to self administer at the onset of a migraine attack are disclosed, and preferably include a needle-free injector and a high viscosity formulation, to eliminate such issues as fear of self administration with needles, and needle stick and cross contamination.Type: ApplicationFiled: April 16, 2013Publication date: September 5, 2013Inventors: Stephen J. FARR, John TURANIN, Roger HAWLEY, Jeffrey A. SCHUSTER
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Patent number: 8523838Abstract: The present invention relates to a connector device to connect a first and a second fluid container, directly or indirectly. The connector device exhibit a first and a second connection means, a pierceable barrier member, a piercing member, a fluid transfer channel and a pressure normalization channel. The pressure normalization channel is arranged to normalize an increasing pressure inside second fluid container. A valve arrangement permitting fluid to flow in a first and a second direction is arranged in the pressure normalization channel. The valve arrangement exhibit a cracking pressure in at least the first direction. The present invention provides for a connector device which reduces the risk of clogging the barrier filter.Type: GrantFiled: December 10, 2009Date of Patent: September 3, 2013Assignee: Carmel Pharma ABInventor: Hakan Tornqvist
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Patent number: 8523806Abstract: A sprayer is capable of inhibiting or preventing clogging occurring in a nozzle upon ejection of a liquid through the nozzle. A sprayer includes liquid supply for separately supplying a first liquid and a second liquid different in liquid composition, and a nozzle. The nozzle includes a first flow path and a second flow path along which passes the first liquid and the second liquid supplied from the liquid supply. In addition, the nozzle includes a third flow path along which passes a gas. A merge part is provided at which the first flow path and the second flow path merge at their respective halfway parts. A vent is provided at the merge part for allowing the gas which has passed through the third flow path to flow into the merge part.Type: GrantFiled: March 11, 2009Date of Patent: September 3, 2013Assignee: Terumo Kabushiki KaishaInventor: Koichi Hayakawa
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Publication number: 20130204183Abstract: A drug delivery device comprises a first component and a second component, wherein a substance is provided on at least one of the first component and the second component. An inner friction of the substance is great enough to stabilize at least one of the orientation and the position of the first component and the second component with respect to one another. The inner friction of the substance is small enough to allow relative movement of the first component and the second component necessary for the intended operation of the device. Furthermore, a method for assembling a drug delivery device is provided.Type: ApplicationFiled: October 25, 2011Publication date: August 8, 2013Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Michael Noderer, Timothy Giles Claughton, Warren Terry, Robert Veasey
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Patent number: 8500681Abstract: The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.Type: GrantFiled: March 21, 2011Date of Patent: August 6, 2013Assignee: Valeritas, Inc.Inventors: Robert R. Gonnelli, David Lipson, Vasu Nishtala, Ciro Dimeglio
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Publication number: 20130190685Abstract: The present invention relates to a needleless injector.Type: ApplicationFiled: January 25, 2011Publication date: July 25, 2013Inventors: Min-Su Cho, Chang-Hee Lee
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Publication number: 20130190684Abstract: A piston for a needleless valve system comprising a head portion configured to be disposed in the needleless valve system and controlling fluid flow through the needleless valve system. The head portion comprising a continuous top surface, and an opening disposed proximate the continuous top surface, wherein the continuous top surface is non-planar when the opening is in an open position.Type: ApplicationFiled: January 20, 2012Publication date: July 25, 2013Inventors: Tyler Devin Panian, Jonathan Yeh
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Patent number: 8491524Abstract: A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.Type: GrantFiled: June 13, 2012Date of Patent: July 23, 2013Assignee: Zogenix, Inc.Inventors: William Henry, Andrew Lewis
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Patent number: 8491468Abstract: A tubular body has a vent hole VA and a suction opening. The piston body is in a state in which the inside of the tubular body in an enclosed space is divided into a front chamber and a rear chamber. The piston body includes piston portion which reciprocate in a position on its front end side from the suction opening, a shaft portion which supports this piston portion on its front end side and whose external diameter is smaller than the internal diameter of the tubular body and a pressing portion provided on a rear end side of this shaft portion. A vent passage is formed in the shaft portion so as to couple a vent hole VB of this pressing portion and a vent hole VC on its front end side of the shaft portion. Further, a spring is provided to return the pressed pressing portion to its original position.Type: GrantFiled: February 17, 2009Date of Patent: July 23, 2013Assignee: FUJIFILM CorporationInventor: Kenji Yamane
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Patent number: 8486002Abstract: Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape having the drug disposed thereon. The device also includes a first collimator fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.Type: GrantFiled: April 19, 2011Date of Patent: July 16, 2013Assignee: Palo Alto Research Center IncorporatedInventors: Scott Uhland, Eric Peeters
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Patent number: 8480617Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.Type: GrantFiled: November 16, 2006Date of Patent: July 9, 2013Assignee: Painless Tech GmbHInventors: Benedikt Lenzner, Stephan Theuer, Bernd Störmer-Talleur, Dirk Schulz
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Patent number: RE44846Abstract: A jet injection device with a fluid chamber in a housing member for holding about 0.02 ml to about 3 ml of a medicament. An injection-assisting needle has an injection end that extends from the housing for inserting into a patient to a depth of up to about 5 mm. A force-generating source is configured to apply a pressure reaching about 100-1000 psi to the medicament in the chamber to expel the medicament through the injecting end of the needle.Type: GrantFiled: June 22, 2012Date of Patent: April 15, 2014Assignee: Antares Pharma, Inc.Inventors: Peter L. Sadowski, David M. Deboer, Claude L. Berman, Paul R. Lesch, Jr., Margaret L. Holland