Abstract: A method for reducing human or animal tissue includes making a plurality of excisions to collectively form a patch of tissue to be reduced, instead of making a single large excision in the patch. Thus, scarring after healing is less noticeable. The treated regions of tissue may be arranged such that a total area of all removed tissue segments taken in a direction perpendicular to an axis of the patch changes gradually along said axis. The removed regions of tissue may be navicular in shape, and the patches may be navicular in shape in the event an elongated excision is made. The removal of tissue regions can be realized by proper treatment methods such as incisions and laser treatment.

Abstract: A method enabling relatively pain-free wound debridement is provided. The method entails double-delivering ultrasound to the wound and dissecting material to be debrided with a cutting edge. Delivering ultrasound energy via a coupling medium to an area of the wound within the vicinity of the material to be debrided and exposing the material to be debrided to ultrasound vibrations as to induce vibrations about the point of dissection, the double-delivery of ultrasound elicits an effect allowing for relatively pain-free debridement. While the effect elicited by the double-delivery is in place, the material to be debrided is dissected with a cutting edge.

Abstract: The present invention provides novel medical instruments and methods for fabricating them by using nano-technology processes.

Abstract: A dilation device (206) for an intra-body lumen, for example, a urethra partially occluded by an enlarged prostate in the form of a resilient curved body configured to be implanted in a cut around the lumen, and a method for dilating such a lumen by implanting a dilation device in a cut around the outside of the lumen. Also, a deployment system (300) including a delivery device for the implant, and a device for dilating the lumen before and while the cut is being made, and a method of using the implant and the deployment system. The implant may be formed of a strip or a coiled wire. The cut may be performed in part by the implant. The cut may be performed by a sharp edge, and/or by application of electrical current to the area being cut, or by a piezoelectric transducer.

Abstract: A surgical device includes a first jaw and a second jaw in opposed correspondence with the first jaw. A first driver is configured to cause relative movement of the first jaw and the second jaw in a plane. The first driver is configured to engage a drive shaft rotatable about a rotation axis arranged in non-parallel, e.g., perpendicular, correspondence to the plane. The device may also include a surgical member, e.g., a cutting and stapling element, disposed within the first jaw. A second driver is configured to cause relative movement of the surgical member in a direction parallel to the plane. The second driver is configured to engage a drive shaft rotatable about a rotation axis arranged in non-parallel correspondence to the plane.

Abstract: A fluid injection device includes a fluid supply unit that accommodates and supplies fluid, a fluid injection unit that injects fluid supplied from the fluid supply unit, and a driving waveform generating device which is equipped with at least one adjusting device, a one-input multiple-control parameter changing unit that simultaneously changes plural control parameters for determining a fluid injection condition of the fluid injection unit on the basis of a signal from the at least one adjusting device, and a driving waveform generator that generates and outputs a driving waveform of the fluid injection unit on the basis of the control parameters set by the one-input multiple-control parameter changing unit.

Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.

Abstract: A powered surgical apparatus for use with a source of irrigation fluid and a source of suction and for powering a surgical tool such as a cutting blade. The surgical apparatus includes a handpiece and a cutting blade retention assembly integrated in passage in a distal end of the handpiece. The retention assembly includes an aligned, pair of radially movable buttons, aligned in axially extending passages in communication with the passage in the distal end of the handpiece, the movable buttons can engage with and cause rotational movement of a collet member assembly rotatably supported in the passage in the distal end of the handpiece.

Abstract: A surgical instrument including an end effector that has a selectively reciprocatable implement movably supported therein. The implement is selectively advanceable in a distal direction upon application of a rotary actuation motion thereto and retractable in a proximal direction upon application of a rotary retraction motion thereto. An elongate shaft assembly is coupled to the end effector and is configured to transmit the rotary actuation motion and rotary retraction motion to the reciprocatable implement from a robotic system that is configured to generate the rotary actuation motion and said rotary retraction motion.

Abstract: This is a surgical scalpel that has a skirt preventing blood, pus or waste fluids from squirting into the Doctors face and body while the Doctor is performing any procedure that entails cutting into a human or animal. It is the correct scalpel to use when performing the initial incision or cut.

Abstract: Medical devices for cutting and suturing biological tissue generally include a shaft and first and second guide members each including a first portion coupled to the shaft at a first location and a second portion coupled to the shaft at a second location. The first portions are movable along the shaft relative to the second portions, and the first and second guide members define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device may further include a blade positioned between the first and second guide members. When used to suture tissue, one or more suture guides may be provided on the first guide member for directing a suture needle through tissue proximate the first guide member. Methods of repairing and replacing a meniscus using the medical devices are also provided.

Abstract: A scalpel blade accessory and cartridge are provided wherein a tubular guard is slidable over the scalpel blade carrier between a retracted position in which the blade carrier is positioned to expose any scalpel blade associated with it for use and an extended position in which the guard covers the blade carrier and any blade thereon. The scalpel blade has a mounting slot for attachment to a lug on a standard scalpel handle for use. The blade carrier has a bridge spanning an alignment face so as to provide space for a scalpel blade between the alignment face and bridge. A blade catch cooperates with a rear end of the mounting slot to hold a relevant scalpel blade captive. The blade catch is disengagable by assembling it onto a standard handle, in use.

Abstract: Devices, apparatus, and methods of using a modified scalpel tool that is removable from a polyurethane mated sheath for use in carpal tunnel surgeries and the like. The modified scalpel tool has an elongated stem with a flat blade at the distal end and an elongated handle at the proximal end. The sheath has a cavity for allowing the elongated blade to be inserted therein, two slots to receive two metal studs and a handle at its proximal end. The flat blade tool-polyurethane when combined (mated) produces a stable configuration that allows motion in only one rotational plane and with an arc of 90-95 degrees.

Abstract: The invention comprises an atherectomy probe for mechanically cutting core prostatic tissue to alleviate the condition of benign prostatic hyperplasia (BPH) or for use in orthopedic procedures. The blade shapes and lengths are adaptable but in a preferred embodiment the device includes an end-cutting bur tip. The cutting motion may be one of: guillotine (incising between two parallel edges), radial reciprocating (changing radial directions and cuts between two horizontal edges), circular (continuously radial in one direction), and end-cutting, etc. The power source used to drive the blade may be one of: pneumatic, hydraulic, manual mechanical, electrical, solar, etc. The probe also includes several channels that may be used for providing live aspiration and removal of severed tissue and fluids, as well as insufflation of gases and optionally, pharmaceuticals and/or a secondary therapy.

Abstract: A medical device may include a sheet member having a first surface and a second surface to engage a surface of a body tissue. The medical device may include an incision guide extending along a length of the sheet member. First and second portions of the sheet member may be positioned on respective first and second sides of the incision guide. The sheet member may be severable along the incision guide to separate the first portion and the second portion from one another. A first magnetic member may be positioned on the first portion, and a second magnetic member may be positioned on the second portion. The first and second magnetic members may be attracted to one another to magnetically couple the first portion and the second portion to one another. The medical device may include an alignment mechanism for aligning the separated first and second portions with one another.

Abstract: A surgical cutting guide is described which can guide a cutting implement to cut in a pair of planes at a defined relative orientation. The cutting guide comprises a first plate defining a first cutting plane, a second plate defining a second cutting plane at an angle to the first cutting plane; and a base member to which both the first plate and the second plate are attached. The first and second cutting planes intersect each other at a line of intersection and both the first plate and the second plate extend beyond the line of intersection.

Abstract: A suture cutting device is provided, the device suitable for cutting high strength suture materials used in arthroscopic surgeries. The device includes a distal blade portion movable within a distal suture guide, the distal suture guide including a lateral suture guide slot. The distal blade portion includes a dorsal recess that, in combination with an upper wall of an enclosed blade guide slot, controls an amount of dorsal movement of a cutting edge during a longitudinal movement of the cutting edge. The combined dorsal movement and longitudinal movement of the cutting edge creating a sliding/slicing movement of the cutting edge against a suture in the suture guide slot. At least a proximal blade portion and an extension blade portion are made of a single blade, those portions defining a spring, contacting a trigger, and effectuating a movement from a first position to a second position.

Abstract: A biopsy probe assembly is configured for installation on a driver assembly. The biopsy probe assembly includes a plurality of components, each of the plurality of components being movable relative to another of the plurality of components, and each of the plurality of movable components having a respective alignment feature, wherein collectively the biopsy probe assembly has a plurality of alignment features. The plurality of alignment features of the plurality of components is aligned to form a continuous passage. A safety alignment pin is inserted into the continuous passage so as to lock relative positions of the plurality of components.

Abstract: The invention provides a single surgical procedure by using autologous platelet-rich fibrin (PRF) and cartilage fragments to solve problems of contamination during incubation of chondrocytes and transplant rejection in vivo, which has the benefit of a more efficient and shorter recovery time. The invention also provides a device for easily and rapidly cutting cartilage to cartilage fragments so as to reduce contamination of the implant and infection.

Abstract: A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.

Abstract: A surgical tool system including a handpiece with a motor and a cutting accessory with a shaft that is rotated by the handpiece motor. The handpiece includes a coupling assembly with plural locking elements for holding the accessory shaft to an output drive shaft that is actuated by the handpiece motor. The locking elements are longitudinally spaced apart from each other. The accessory shaft is formed with retention features against which the handpiece locking elements engage. The shaft retention features are in columns. The retention features in adjacent retention features are longitudinally offset from each other. This allows the coarse or fine adjustment of the extent to which the accessory shaft extends forward from the handpiece coupling assembly.

Abstract: A biopsy device includes a coring cannula, a retract stylet, and a localization needle. The coring cannula has a longitudinal axis and a shaft centered on the axis. The stylet has a tip containing at least one blade and a central passage. The localization needle has a channel and is slidably disposed within the central passage. A drive mechanism rotates the cannula and moves the cannula in a direction parallel to the longitudinal axis of the cannula. A guide element has a first end and a second end and is slidably disposed within the channel of the localization needle. The guide element is movable from a first position to a second position within the localization needle.

Abstract: An attachable clamp for use with a surgical instrument is disclosed. The attachable clamp comprises a body portion, a first jaw member, a second jaw member and an actuation mechanism. The body portion defines a longitudinal axis and has attachment members configured to attach to an elongate portion of a surgical instrument. Each of the first jaw member and second jaw member extends distally from the body portion. The actuation mechanism is disposed in mechanical cooperation with at least one of the first jaw member and the second jaw member. Actuation of the actuation mechanism moves at least one of the first and second jaw members between an approximated position and an open position with respect to the other jaw member.

Abstract: Liquid is ejected in a pulse-like manner from a nozzle provided at the distal end of a liquid ejection pipe. When the liquid is ejected, moving speed of the nozzle is detected. A driving frequency of a piezoelectric element is increased when the moving speed increase. The driving frequency is reduced when the moving speed decreases. Consequently, it is possible to prevent the number of times the liquid is ejected per unit length from changing according to the moving speed of the nozzle. Therefore, it is possible to excise a biological tissue at stable excision depth.

Abstract: In accordance with the present invention there is provided a suture trimmer, the suture trimmer comprising a shaft having a proximal end and a distal end and an axis therebetween, the shaft having a groove formed in the side thereof, the groove in communication with an opening formed in the side of the shaft, the opening disposed proximal the distal end. The suture trimmer further including a cutting member slidably disposed within the shaft, and a suture retainer slidably disposed within the shaft. Wherein the suture trimmer in accordance with the present invention may be additionally utilized to position knots formed within a suture loop prior to trimming the free end(s) of the suture loop.

Abstract: A liquid injection device includes: a chamber which supply of the liquid and connects with the injection nozzle; a chamber volume varying unit to which driving voltage is applied to reduce the volume of the chamber to a volume smaller than the volume of the chamber before the driving voltage is applied; a driving voltage applying unit which applies the driving voltage to the chamber volume varying unit with the liquid supplied to the chamber; a pseudo noise data memory unit which stores sound data of pseudo noise having audible frequency components contained in driving noise generated when the driving voltage is applied to the chamber volume varying unit; and a pseudo noise outputting unit which outputs the pseudo noise by using the sound data of the pseudo noise such that the sound pressure of the driving noise decreases within the audible frequency range when the driving voltage is applied.

Abstract: A forceps includes a housing defining a window and having an outer shaft extending therefrom. An end effector assembly disposed at a distal end of the outer shaft includes first and second jaw members including distal portions and proximal portions and movable between spaced-apart and approximated positions. An inner shaft is slidably disposed within the outer shaft such that, when the jaw members are disposed in the spaced-apart position, the inner shaft is disposed in a distal position. When the jaw members are moved to the approximated position, the proximal portions urge the inner shaft to a proximal position. An indicator member coupled to the inner shaft includes first and second indicators. The first indicator is visible through the window when the inner shaft is disposed in the distal position. The second indicator is visible through the window when the inner shaft is disposed in the proximal position.

Abstract: The present invention provides an apparatus for, and a method of, accurate positioning of endoscopic instruments. Accurate positioning of the instruments is accomplished through the inclusion of a steering ability within the device. After the endoscopic instrument is properly positioned, the present invention may use rapid exchange technology, soft locks, and mechanical locks to maintain the position of the endoscopic instrument. Rapid exchange technology is used to minimize displacement forces present on the guidewire or catheters. Soft locks and mechanical locks resist movements caused by displacement forces.

Abstract: A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Abstract: A material removing tool, such as a cutting or grinding tool, adapted to be oscillated by the output shaft of a manually operable motor-driven apparatus, is provided with at least one elongated cutting edge defined by teeth or analogous cutting elements arranged in at least one at least substantially straight linear array.

Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.

Abstract: A safety scalpel incorporating a handle similar in thickness, length, weight, balance, shape and feel to the conventional metal handle preferred by most surgeons, and a disposable cartridge assembly that is easily mounted and released from the scalpel handle. The handle comprises a first end and a second end. The cartridge assembly comprises a blade guard/shield that can be slideably mounted onto the second end of the handle, a blade holder/slider that can be disposed within the blade guard, and a blade that can be attached to the blade holder. The safety scalpel incorporates a locking system that prevents the cartridge assembly from sliding off or wobbling on the handle during use.

Abstract: A medical device that is composed of a sterilizable material, is used to create thin cartilage discs, and includes a device body and a cover with a plurality of holding devices, each of which includes a section that with a recess located in the top side of the device body, the recess being entirely or partially enclosed by a delimiting ridge, and being closable via a projection located on the top side of the cover, and in which the lateral delimiting ridge has a guide slot, into which a cutting blade is inserted and guided via an end face of the section and extends, at a distance that differs for each section, parallel to the bottom surface of the particular recess. It is therefore possible to create thin cartilage discs having certain, different thicknesses and a consistent level of quality, even without using the known shims.

Abstract: A cartridge includes a body, a reservoir, a filter, and a tab. The body is configured to be held in a fixed relationship relative to a stem, wherein the body comprises an inlet and an outlet. The inlet is configured to receive a fluid from a surgical instrument via the stem. The outlet is configured to output a first portion of the fluid from the cartridge. The reservoir is configured to receive the fluid from the inlet. The filter is configured to filter the first portion of the fluid as the first portion of the fluid is directed from the inlet, through the filter, and to the outlet. The tab connected to the body and configured to engage with the stem. The tab is configured to, when the cartridge is moved to disengage from the stem, at least one of break away from the body and become functionally inoperable.

Abstract: A surgical instrument, in particular a laminectomy rongeur or a conchotome, with a shaft and with a one-piece sliding part, longitudinally displaceable relative to the shaft, with which for longitudinal displacement a grip part is associated which is pivotable about a pivot axis, wherein the sliding part is able to be transferred from a working position, in which the sliding part is guided longitudinally displaceably on the shaft in a guide, into a cleaning position, in which the sliding part is freed from the guide and is pivotable relative the shaft about a rotation axis oriented perpendicularly to the longitudinal extent of the shaft. The rotation axis is aligned perpendicularly to the pivot axis of the pivotable grip part.

Abstract: Some embodiments of the invention provide an instrument for mechanically removing segments of tissue from a patient during a minimally invasive surgical procedure. An exemplary instrument provides an inlet for receiving tissue a mechanism for cutting away received tissue and for simultaneously moving the cut away tissue away from the inlet to allow additional material to enter the inlet for removal wherein multiple specimens can be captured and eventually removed from the patient's body without the need of removing the instrument after each capture.

Abstract: A surgical instrument is provided for cutting bone and other tissue. The surgical instrument is powered by a pressurized fluid and includes a rotatable shaft connected to a dissection tool. The instrument includes a housing member comprising a one-piece base. A rotor housing chamber is defined by the base, and the rotatable shaft is located in the rotor housing chamber. A first bearing housing is defined by the base, located adjacent the rotor housing chamber, and houses a first bearing that engages the rotatable shaft. A second bearing housing is defined by the base, located on an opposite side of the rotor housing chamber from the first bearing housing, and houses a second bearing that engages the rotatable shaft. A passage is defined by the base and operable to direct a pressurized fluid through the base to the rotor housing chamber in order to rotate the rotatable shaft.

Abstract: A method for reducing skin is disclosed, in which a plurality of incisions or removals are made to collectively form a patch of skin to be reduced, instead of making a single large treatment of the patch. Thus, scarring after healing is less noticeable. Preferably, the treated regions of skin are arranged such that a total area of all removed skin segments taken in a direction perpendicular to an axis of said patch changes gradually along said axis. The removed regions of skin are preferably navicular in shape, and the patches are preferably navicular in shape in the event an elongated incision is made. The removal of skin regions can be realized by proper treatment methods such as incisions and laser treatment. The mask may be attached to the patch of skin to be treated after said skin is stretched.

Abstract: A surgical instrument is provided for cutting bone and other tissue. The instrument includes a housing. A plurality of sensors is located in the housing in a spaced apart orientation from each other. A collar is moveably mounted to the housing into a plurality of different collar orientations on the housing. A lever comprising an actuator is moveably coupled to the collar and, with the collar located in any one of the plurality of different collar orientations, the lever is operable to move the actuator relative to one of the plurality of sensors in order to vary a signal produced by that sensor.

Abstract: A method and system for controlling the cutting speed of a cutting device employable in an ocular surgical procedure is provided. The apparatus includes a control module, a variable gas pressure regulator arrangement configured to receive gas from a gas pressure supply, wherein the variable pressure regulator arrangement is connected to the control module and the control module is configured to regulate gas received from the gas pressure supply, and an accumulator configured to store gas received from the variable gas regulator arrangement at a selected gas pressure. Gas at the desired pressure is delivered from the accumulator to the cutting device. The gas may be air, and the variable gas pressure arrangement may include a single variable pressure regulator or multiple pressure regulators which typically are not variable with respect to the pressure delivered.

Abstract: An ophthalmic surgical method comprising a step of at least partly removing the vitreous humour, which also comprises a step of highlighting the vitreous to be removed using a coloured composition which selectively highlights the vitreous, allowing a distinction between the vitreous and the other structures of the eye, said distinction facilitating vitreous removal, wherein the coloured composition comprises a polymeric dye comprising at least one backbone to which at least one reactive dye is chemically linked; in a preferred embodiment the polymeric dye being a blue dextran.

Abstract: An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed.

Abstract: A surgical scalpel is presented which combines the attributes of cost-effectiveness in design while being ambidextrous and autoclavable. The design of the device affords left handed or right handed medical personnel with the feel, weight and balance of the original metal unguarded scalpel, while maintaining safety through the shielding of the blade during non-use and the ability to dispose of the blade in a safe controlled manner without having to place ones hands near the unguarded sharp. Surgeons of either dexterity are able to learn and operate using similar techniques and instruments heretofore not available to them. No longer must a left handed surgeon be forced into the right handed world to perform surgery. The device is designed to use existing styles of blades currently available without needing costly inventories of specially created blades for the multitude of other such devices on the market.

Abstract: A concealed-blade scalpel includes an elongated housing forming an interior cavity and an opening at one end of the housing to provide access to the interior cavity. A surgical cutting blade is mounted within the cavity for sliding movement relative to the housing so that the blade can be moved between (1) a retracted position in which the cutting edge of the blade is located entirely within the cavity, and (2) an advanced position in which the cutting edge of the blade is positioned outside the housing to permit the blade to be used for cutting. An actuator is coupled to the blade for manually moving the blade to the advanced position in response to manual pressure applied to the actuator, and a biasing element continuously urges the blade toward the retracted position for automatically retracting the blade.

Abstract: A method for reducing skin is disclosed, in which a plurality of incisions or removals are made to collectively form a patch of skin to be reduced, instead of making a single large treatment of the patch. Thus, scarring after healing is less noticeable. Preferably, the treated regions of skin are arranged such that a total area of all removed skin segments taken in a direction perpendicular to an axis of said patch changes gradually along said axis. The removed regions of skin are preferably navicular in shape, and the patches are preferably navicular in shape in the event an elongated incision is made. The removal of skin regions can be realized by proper treatment methods such as incisions and laser treatment.

Abstract: A dicing device dices tissue harvested from a patient. The dicing device comprises a grid cutting element and a tray to receive diced tissue. The dicing device may be integrated into an otherwise conventional biopsy device. The diced tissue specimens may be further processed, such as by being introduced into a self-expanding fistula plug creation and delivery system. The self-expanding fistula plug creation and delivery system comprises a sheet and a reinforcement tube. A scaffold material may be placed in the sheet, which may then be folded and reinforced, with the scaffold material being compressed in the sheet. The scaffold material may then be pushed into a catheter end. The catheter end may be inserted in a fistula. The scaffold material may then be flushed with a cell matrix that is based on the diced tissue to create a fistula plug, which may be left in the fistula.

Abstract: Instruments for use in minimally invasive carpal tunnel release include a cannula and a cutting member movable longitudinally within the cannula to advance a cutting blade of the cutting member along a longitudinal slot in the cannula to sever a transverse carpal ligament disposed over the slot. A dilating member is provided for creating a subligamentous space to accommodate the cannula and/or for removing adhered synovium from a lower surface of the ligament. A method for minimally invasive carpal tunnel release involves establishing a proximal entry into the carpal tunnel from an incision in the volar aspect of the forearm, introducing the cannula in the carpal tunnel via the incision, and severing the transverse carpal ligament from proximal to distal with the cutting blade of the cuffing member under direct endoscopic visualization.

Abstract: A surgical instrument for the dissection of bone and other tissue includes a spindle, a dissection tool and a coupler disposed between the spindle and the dissection tool. The coupler includes a tool collet and an attachment locking mechanism operable to permit tool collet operation and telescoping movement of an attachment tube with respect to the dissection tool. A method is also provided for convenient coupling of the dissection tool and adjustment of the attachment tube length.

Abstract: In various embodiments, an assembly of a surgical instrument is disclosed. The assembly includes a housing, a cutting member relatively movable with respect to the housing, and an agent cartridge connected to the housing. The agent cartridge houses a medical agent. The assembly is configured to deliver the medical agent proximate a cutting surface of the cutting member.

Abstract: According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., an elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). The device (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. The invention also provides a method of treatment for morselizing and removing tissue from within the patient and creating a void within the patient and introducing a therapeutic agent and/or a bulking agent into the void.