Abstract: A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Abstract: Surgical instruments and techniques are provided for creating a pneumostoma through the chest wall into the lung of a patient. The pneumostomy instruments and techniques may be used to create a pneumostoma which allows gases to escape from the lung through the chest wall and thereby treat chronic obstructive pulmonary disease.

Abstract: A medical device including an elongate member having a proximal end and a distal end and an end-effector disposed at the distal end of the elongate member is disclosed. The end-effector further includes a plurality of arms, which may pivot or move relative to one another. Further, each arm includes an inner edge defining a cutting edge, and an outer edge having at least one geometric feature for manipulating tissue.

Abstract: A fluid injection device includes a fluid supply unit that accommodates and supplies fluid, a fluid injection unit that injects fluid supplied from the fluid supply unit, and a driving waveform generating device which is equipped with at least one adjusting device, a one-input multiple-control parameter changing unit that simultaneously changes plural control parameters for determining a fluid injection condition of the fluid injection unit on the basis of a signal from the at least one adjusting device, and a driving waveform generator that generates and outputs a driving waveform of the fluid injection unit on the basis of the control parameters set by the one-input multiple-control parameter changing unit.

Abstract: Disclosed herein is a surgical instrument having a cylindrical tube affixed thereto. The axis of the cylindrical tube is aligned with a central axis of the surgical instrument so it can be advanced along a guidewire.

Abstract: Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal.

Abstract: Tissue may be cut and extracted from an interior location in a patient's body using a probe or tool which both effects cutting and causes vaporization of a liquid or other fluid to propel the cut tissue through an extraction lumen of the cutting device. The cutting may be achieved using an electrosurgical electrode assembly, including a first electrode on a cutting member and a second electrode within a cutting probe or tool. Thus, over a first cutting portion, radio frequency current may help cut the tissue and over a second or over transition region, the RF current may initiate vaporization of the fluid or other liquid to propel the tissue from the cutting device.

Abstract: A scalpel guide system for a bladed surgical instrument. A pair of wire guides attach to a scalpel, for controlled travel of the scalpel along the wire. The wire guides of the scalpel guide system are especially useful as an enhancement to the “Seldinger technique,” or any surgical procedure employed for the percutaneous placement of elongated, tubular devices, with the aid of a guidewire or filament wire. The scalpel can be any knifelike surgical device, conventionally including a blade attached to a handle. The scalpel guiding system preferably includes a pair of wire guides, each extending from the scalpel, which can be disposable, as can the blade, independent of the scalpel. The pair of wire guides each have generally open funnel-shapes, with their wider portion facing the gap formed between the two guides. The user places this medal gap on the wire and rotates the scalpel to engage the wire.

Abstract: A method of treating glaucoma is described. The method includes creating an incision at or near the limbus of an eye and treating glaucoma by inserting a treatment probe through the incision to act on an eye structure adjacent to or near the incision.

Abstract: A fluid jet device including a fluid chamber with variable capacity and a capacity varying section adapted to vary the capacity of the fluid chamber in response to supply of a drive signal. A drive waveform section making the capacity varying section operate so as to compress the capacity of the fluid chamber and a restoring drive waveform section making the capacity varying section operate to restore the capacity of the fluid chamber before compressing the capacity in a signal waveform. The drive signal supply section controls supply content of the drive signal to provide a restoring period adapted to restore a steady state of the fluid flowing toward an inside of the fluid chamber in a period from when the compressing drive waveform section in the drive signal is supplied to when a subsequent compressing drive waveform section is supplied.

Abstract: An insertion system having a base unit for placing on the body of a patient and an insertion device that can be coupled to the base unit, wherein the insertion device comprises an insertion needle holder for holding an insertion needle and a drive mechanism for displacing the insertion needle holder in a pricking direction. According to the invention, the insertion device comprises a locking mechanism causing locking of the drive mechanism in an active state and being set to an inactive state in which the locking is released by coupling the insertion device to the base unit.

Abstract: A surgical instrument which both incises and splits the nucleus of a lens has a pair of 5 spring steel segments slidably received in a metallic tube. Each segment terminates in a tip. As the spring steel segments are drawn into the tube the tips come together to form a cutting edge useful for incising the lens. When the segments are extended from the tube the tips separate, forcing the incision open until the lens is split.

Abstract: A surgical knife safety device having a handle, a blade connected to the handle, and a guard carried by the handle for sliding movement between a retracted position in which the blade is exposed for use, and an extended position for covering the sharp cutting edge of the blade. In the retracted position, an enlarged guard radius is provided at the distal end of the handle to allow improved handle control and blade orientation. The enlarged guard radius is positioned to allow the user to firmly grip a large distal handle portion which is preferably molded as a single piece with the blade holder, preventing unwanted blade or handle movement due to guard mechanism tolerances.

Abstract: A steerable catheter system to perform a transseptal puncture procedure comprises a steerable catheter shaft with at least one inner lumen, and an inner element slidably positioned within a shaft lumen, wherein the distal tip of the shaft can be deflected, counter-deflected, rotated, and counter-rotated and wherein the inner element can be deployed or retracted. In one embodiment, a single steerable catheter is capable of performing an intended procedure and a transseptal procedure all in one, wherein the catheter comprises an outer steerable catheter and an inner element which can be deployed to perform a transseptal puncture, and wherein, once the inner element crosses the inter-atrial septum, the catheter itself can slide forward without advancement of the inner element.

Abstract: Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a patient. Methods can be used at the time of initial diagnosis of malignant tumors to identify a group of patients with a high potential to develop progression or metastasis later. Therefore, methods not only are able to provide very useful prognostic information for patients but also can help clinicians to select a candidate patient likely to benefit from early and aggressive cancer therapy. Methods and compositions for the treatment of cancer associated with expression of IMP3 are also provided.

Abstract: A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye. A sliding element is disposed within the handpiece and a suction cup is mounted to the sliding element. The sliding element can be translated to move the suction cup into and out of the handpiece. A compression mechanism associated with the suction cup and the handpiece compresses the suction cup for deployment through the tip of the handpiece. The suction cup can expand inside the anterior chamber into a cutting position on the lens capsule. A cutting element mounted to the suction cup is used to cut a portion of the lens capsule and to remove the portion from the eye.

Abstract: [Problem] To provide a medical cutting tool with low impalement resistance. [Solution] The edged medical cutting tool comprising a knife, trocar or cutting suture needle has a sharp edge (1) for incising living tissue and a flat part (2) that configures the edge, and the color of the portion of the flat part (2a) along the edge (1) differs from the color of the rest of the flat part (2b). The difference in color results from a difference in the thickness of an oxide film. Another edged medical cutting tool is configured of austenite stainless steel and has a sharp edge (1) for incising living tissue and a flat part (2) that configures the edge. The chrome content of the portion of the flat part (2a) along the edge is higher than the chrome content of the rest of the flat part (2b).

Abstract: A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described. The device includes a handpiece and an outer cannula in which a reciprocating inner cannula is disposed. The inner cannula includes a hinge between a body section and a cutting section that allows the cutting section to pivot when the inner cannula reciprocates within the outer cannula. A tissue collector is also provided and is in fluid communication with the lumen of the inner cannula. The outer and inner cannulae are offset from the motor and drive assembly, and the center of gravity of the device is in the forward part of the device, providing an ergonomic design that is particularly suited for neurosurgical applications.

Abstract: A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Abstract: A method and apparatus for creating minimal skin incisions and soft tissue tunnels, particularly useful in the insertion of transverse or oblique screws through a bone and the holes in a locking nail embedded within the intra-medullary cavity of the said bone. A unique surgical tool, as described herein, is used in conjunction with the novel method herein described, wherein the surgical tool is used in conjunction with a targeting guide and targeting guide tunnel to create skin and soft-tissue tunnels that are precise, of minimal size, and minimally traumatic for the patient, and very quick and easy for the surgeon to create and to repair.

Abstract: A dermatological skin treatment device is provided. The device comprises a handpiece and a cutting tool, wherein the tool is inserted through the conduit and percutaneously inserted into a tissue disposed within a recessed area of the handpiece. The device and method cut the fibrous structures under the skin that cause cellulite at an angle substantially parallel to the surface of the skin and replace these structures with a non-cellulite forming structure by deploying a highly fibrous mesh through a single needle hole to create a highly fibrous layer directly or through wound healing processes.

Abstract: The present disclosure relates to a forceps that includes a housing, a cutting assembly, and an actuator. The housing has a shaft attached thereto that extends therefrom and is configured to support a pair of jaw members at a distal end thereof. The jaw members are movable to grasp tissue therebetween. The cutting assembly includes a spring element that has proximal and distal ends. The proximal end of the spring element is fixed to a boss disposed within the housing and the distal end of the spring element includes a cutting edge. The spring element is coiled at a proximal end thereof to create a spring bias against the boss. The actuator is operably coupled to the spring element and is configured to selectively advance the cutting edge of the spring element into the jaw members against the spring bias to sever tissue disposed therebetween.

Abstract: A medical balloon catheter including a catheter shaft and an inflatable balloon secured to a distal portion of the catheter shaft. One or more cutting blades are secured to the inflatable balloon by a first polymeric adhesive material forming a mounting pad encasing a base portion of the cutting blade therein, and a second polymeric adhesive material adhesively bonding the mounting pad to a surface of the balloon. The first polymeric adhesive material has a first ductility and the second polymeric adhesive material has a second ductility greater than the first ductility.

Abstract: Disclosed is a surgical tool holder adapted to connect to a disposable cutting tool, and the surgical instrument combination. The tool holder has a shank with a quick tool coupling at one end and a drive adaptor at a second end. The coupling assembly has a coupling interface for holding the tool, and has a debris reservoir. A locking mechanism is engageable with the shank by a lock interface that holds the coupling assembly in functional assembly, and when unlocked allows component parts of the coupling assembly to be separated for cleaning and sterilization. The surgical tool has a flat base and complementary fittings adapted to be received by the holder's coupling interface. The combination of the flat base with the reservoir defines a relatively enclosed collection space to receive cutting debris from the tool while the holder and tool are coupled together.

Abstract: The present invention provides a method for creating a beveled needle or a blade. The method employs a side wall surface of an angled post as a base to control beveled tip geometry. The invention provides needles, microneedle arrays, blades and microblade arrays with sufficient sharpness and toughness.

Abstract: An insert 30 comprises a rod 32 having a proximal end 34 and a distal end 36. The insert 30 also comprises a tool 38 which is demountably coupled to the distal end 36. Proximal end 34 is formed with a ball 40 which is configured to seat and engage in a socket of a handle 12 of a laparoscopic instrument 10. The rod 32 fits within a sheath 14 of the laparoscopic instrument 10. The distal end 36 of the rod 32 is provided with an attachment head 42 to facilitate the attachment of the tool 38. A linkage mechanism 44 in the attachment head 42 converts the linear motion of the insert 30 (and in particular rod 32) relative to the outer sheath 14 to a pivotal motion.

Abstract: A surgical device includes a shaft portion coupled to a handle, the handle defining a longitudinal axis. The surgical device also includes a first driver configured to actuate a rotational movement via a first drive shaft and a second driver configured to actuate an articulation movement via a second drive shaft. The surgical device also includes a controller having a first dial and a second dial, the first dial actuated by the first driver and the second dial actuated by the second driver, the second dial positioned within the first dial.

Abstract: Liquid jet surgical cutting apparatus (10) and a method of use thereof are described, the apparatus including a fluid reservoir (12) containing a supply of cutting fluid (14), a pump (16) to supply the cutting fluid to a liquid jet surgical cutting instrument, a liquid jet surgical cutting instrument (20), and a drain conduit (22) to receive and drain waste cutting fluid (14) and entrained debris wherein the drain conduit is operably connected to a waste canister (24), the waste canister having a vacuum generator (26) operably connected thereto to apply a vacuum to an interior of the waste canister and to the drain conduit.

Abstract: A medical device may include an end effector configured to perform a therapeutic procedure. The medical device may further include a guide having a modifiable shape. The guide may be adapted for insertion through a lumen of an access tube. Also, the end effector may be selectively attachable to the guide and configured to move along the guide.

Abstract: [Problem] Because the knife edge of medical knives such as straight knives manufactured with austenite stainless steel is thin and sharp, there is the problem that the knife edge bends too easily when making incisions in the cornea, sclera, etc. during ophthalmologic surgery. The invention provides a medical knife capable of increasing the strength of the thin, sharp knife edge and preventing the reduction of sharpness. [Solution] This medical knife has a flat cutting part and an inclined surface formed along the border of said cutting part. By electrolytic polishing or chemical polishing of the inclined surface, a convexly curved cutting edge is formed on at least the edge of the inclined surface of the knife. The knife edge has a rounded configuration. The knife edge being rounded increases the thickness of the knife edge, increases the strength thereof and hinders bending.

Abstract: The invention relates to a liquid jet scalpel comprising a nozzle (12) for discharge of pressurized liquid (14) in the direction of tissue (16) that is to be manipulated, and a distance measuring device (18) for measuring the distance between the nozzle (12) and the tissue (16) that is to be manipulated. The invention further relates to a method for operating a liquid jet scalpel.

Abstract: A surgical cutting accessory that includes inner and outer tubes. A cutting feature is attached to the inner tube. The proximal end of the inner tube is connected to an inner hub. The inner hub has features for engaging a drive shaft integral with a handpiece to which the accessory is attached. The outer hub has features that facilitate the removable coupling of the hub to the handpiece. The outer hub is formed with a bore through which the inner tube extends. The outer hub also has an inlet port that extends from an outer surface of the hub to the main bore. Irrigation fluid can be flowed through this port into the annular space between the inner and outer tubes. A seal is located adjacent the inlet port.

Abstract: This invention provides a needle for a living body and a process for sampling a tissue with the needle. The needle and the process are used for harvesting a tissue sample from a living body with minimal damage. The needle is made of ceramics, and is provided with a sampling hole for aspirating a sample and with a cooling hole for supplying cooling gas. The holes penetrate through in the longitudinal direction, and have openings on a pricking-end surface of the needle. For the purpose of cutting off the tissue sample, the pricking-end surface is provided with a cutting part positioned between the openings. When the needle is pricked into a body, a tissue is aspirated through the sampling hole while cooling gas is being supplied through the cooling hole. Thus, the tissue is partly frozen or semi-frozen and cut off with the cutting part to harvest by aspiration.

Abstract: The present disclosure relates generally to the field of tissue removal and more particularly to methods and devices for use in medical applications involving selective tissue removal. One exemplary method includes the steps of providing a tissue cutting instrument capable of distinguishing between target tissue to be removed and non-target tissue, urging the instrument against the target tissue and the non-target tissue, and allowing the instrument to cut the target tissue while automatically avoiding cutting of non-target tissue. Various tools for carrying out this method are also described.

Abstract: An exemplary surgical probe and methods of making the same are disclosed. An exemplary surgical probe may include a tubular body and a scissor assembly received at least partially within the body. The scissor assembly may include a first blade fixed to the tubular body that includes a body portion and an end portion. The scissor assembly may further include a second blade that is configured to move longitudinally within the tubular body. The body portions of the first and second blades may each define respective cross sections normal to a longitudinal axis of the tubular body. The cross sections may each define centrally disposed edges adjacent one another, and the cross sections may each be asymmetrical about a line substantially parallel to the centrally disposed edges.

Abstract: Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.

Abstract: A safety scalpel incorporating a handle similar in thickness, length, weight, balance, shape and feel to the conventional metal handle preferred by most surgeons, and a disposable cartridge assembly that is easily mounted and released from the scalpel handle. The handle comprises a first end and a second end. The cartridge assembly comprises a blade guard/shield that can be slideably mounted onto the second end of the handle, a blade holder/slider that can be disposed within the blade guard, and a blade that can be attached to the blade holder. The safety scalpel incorporates a locking system that prevents the cartridge assembly from sliding off or wobbling on the handle during use.

Abstract: A surgical scalpel, scalpel instrument and/or scalpel system (collectively, scalpel), is configured for use in a transverse carpal ligament surgical procedure. The scalpel evaluates an incision path with respect to a nerve in the incision path, and performs the incision if appropriate. The scalpel emits a signal through a potential incision path through tissue captured by the scalpel. The scalpel utilizes the emitted signal to determine whether a nerve is in the incision path. The surgical instrument includes a retractable blade. Evaluation includes determining whether a nerve is present before incision and/or evaluating whether the target tissue has been appropriately captured. A warning is provided when a nerve is in the incision path and/or the captured target tissue is inappropriate. The surgical instrument disables extension of the blade when a nerve is in the dissection path and/or the captured target tissue is inappropriate.

Abstract: A surgical instrument for performing water jet surgical operations comprises a nozzle that can be moved via a hydraulic actuator out of a retracted or passive position into a moved-forward or active position. The actuation is accomplished using hydraulic fluid that is supplied to the instrument head via a tube and/or hose. The fluid (e.g., a sodium chloride solution) that is to be injected into the tissue can be used as the hydraulic fluid that is supplied to the nozzle. High-frequency (HF) current can additionally be applied to the nozzle. The HF current can be conducted to the nozzle via a line extending through the fluid conducting element or via the electrolyte present therein.

Abstract: A retractable safety knife has a hollow handle with an opening at an end thereof, a pusher that is movably disposed within the handle and is operable by a user, and a blade that is connected with an end of the pusher. When the pusher moves from a blade-retracted position to a blade-extended position, the blade extends outwardly from the handle opening and rotates from a nested position to an extended position.

Abstract: A sheath for use with a scalpel cutting device including a sheath body configured to cover a scalpel blade at a distal end of a scalpel cutting device. The sheath advantageously may include a plurality of slots formed therein. Providing two or more slots provides additional functionality and/or ease of manufacturing. A single sheath configuration including a plurality of slots (e.g., two) may be manufactured so as to be used with scalpels including somewhat different blade configurations (e.g., which may require a slightly different slot location). Such a universal sheath allows a single sheath design to be used with multiple scalpels, easing manufacture and reducing costs. In addition, depending on the particular location of the slots and the configuration of the scalpel blade, the different slots may each intersect the scalpel blade and provide different characteristics for cutting a suture.

Abstract: According to embodiments of the present application, a color changeable dye can comprise a redox indicator, a reduction reaction initiator, an electron donor, an oxygen scavenger, an indicator barrier agent, a thickening agent and an agent to facilitate mixing. The color changeable dye is a first color in the presence of oxygen, capable of changing to a second color upon reduction in a substantially oxygen free environment, and capable of changing back to the first color after exposure to oxygen for a period of time corresponding to the intended use time of a disposable or limited use product. Methods of making and using the color changeable dye and apparatuses incorporating such dye are also disclosed.

Abstract: A medical implant comprising a transducer element which induces mechanical vibrations of the implant when electrically and/or magnetically controlled.

Abstract: A modular device for tissue resection includes a housing, a motor, a tissue receiving chamber, a grabbing mechanism and a resection mechanism. The housing includes a guide track receiving lumen extending therethrough. The motor is mounted within the housing. The motor is selectively engageable with a guide track received within the guide track lumen to move the modular device therealong. The tissue receiving chamber is formed within the housing. The grabbing mechanism draws a selected portion of tissue into the tissue receiving chamber. The resection mechanism resects the selected portion of tissue.

Abstract: Devices and related methods are disclosed that generally relate to surgical devices provided for use in various surgical procedures. In some embodiments, the surgical devices can include a handle housing and an elongate shaft having opposed jaws disposed at a distal end thereof. The handle housing can have a handle portion and a trigger configured to pivot relative to the handle portion to open and close the opposed jaws. A biasing switch can generally be disposed in and/or on the handle housing and can be selectively movable between a first configuration in which the opposed jaws are biased to an open position, and a second configuration in which the opposed jaws are biased to a closed position.

Abstract: An extender for use in an electro-mechanical surgical system that includes a surgical attachment that may be detachably coupled to an electro-mechanical driver device via a flexible shaft. The extender is a substantially rigid extender that includes a proximal end that may be detachably coupled to a distal end of the flexible shaft. The extender also includes a distal end that may be detachably coupled to the surgical attachment. The extender also includes at least one rotatable drive shaft configured to engage and be secured with a respective rotatable drive shaft of the flexible shaft such that rotation of the respective rotatable drive shaft of the flexible shaft by the electro-mechanical driver device causes the at least one rotatable drive shaft of the extender to rotate, thereby rotating a complementary connector of the surgical attachment so as to operate the surgical attachment.

Abstract: A hair regrowth system consisting of sensitization, growth, and maintenance kits for alopecia areata and related alopecia balding conditions. Graduated doses of specific engineered and or extracted haptens are included in a sensitization kit for initiating immune system response in hairless areas. A growth kit containing topical hormones to increase papilla size and vigor and a maintenance kit to sustain immune system response and papilla size and vigor for the long term are included in some embodiments.

Abstract: Tools and methods are provided for removing biological units from a body surface utilizing a removal tool. The tool is of a concentric tube configuration comprising first and second elongated bodies, in which the second elongated body can be retracted into the first elongated body. The tool may incorporate retention members and mechanisms configured to impede movement of the biological unit in the direction of a distal end of the tool and to improve retention of the biological unit in the tool. Distal fluid or gas delivery may supplement a vacuum in a luminal space to help extract biological units from surrounding tissue.

Abstract: Lancing system comprising a needle and a lancing device The lancing device comprises a housing with a housing opening that is surrounded by a housing skin contact surface. A lancing depth reference element with a reference skin contact surface is adapted in such a manner that the reference skin contact surface at a reversal point of the lancing movement is in contact with the skin. The lancing depth is determined by the distance between the reference skin contact surface and the tip of the needle element at the reversal point of the lancing movement. The lancing depth reference element is in a stationary defined position relative to the reversal point of the lancing movement. The lancing depth reference element is adapted to stabilize the skin when pressed against the reference skin contact surface with respect to a skin deformation which occurs upon lancing of the skin.

Abstract: A bone biopsy device includes an outer cannula having a mouth with a cutting edge to section a frustule of spongy bone, a plate mounted slidably within the cannula and provided with a semi-cylindrical portion at its distal end, and a stylet mounted slidably within the plate and provided with a pointed tip which protrudes from the mouth of the cannula to pierce the compact part of the bone. The mouth of the cannula has on its inside a narrowing and the semi-cylindrical part of the plate has at its distal end at least one pair of opposed circumferential sets of teeth adapted to bend radially inwards when they encounter the narrowing of the mouth, to clasp the base of the sectioned frustule and allow extraction of the frustule by the plate while the cannula is kept at the operating site, allowing aspiration of marrow after the frustule has been removed.